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Professor Kelly Chibale

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Gonzàlez Cabrera D, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K. Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria". Antimicrob Agents Chemother. 2018 11; 62(11). PMID: 30355750.
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    2. Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Cabrera DG, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K. UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria. Antimicrob Agents Chemother. 2018 09; 62(9). PMID: 29941635.
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    3. Okombo J, Chibale K. Correction: Recent updates in the discovery and development of novel antimalarial drug candidates. Medchemcomm. 2018 03 01; 9(3):590. PMID: 30288210.
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    4. Okombo J, Chibale K. Recent updates in the discovery and development of novel antimalarial drug candidates. Medchemcomm. 2018 Mar 01; 9(3):437-453. PMID: 30108934.
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    5. Kumar M, Singh K, Ngwane AH, Hamzabegovic F, Abate G, Baker B, Wiid I, Hoft DF, Ruminski P, Chibale K. Reversed isoniazids: Design, synthesis and evaluation against Mycobacterium tuberculosis. Bioorg Med Chem. 2018 02 15; 26(4):833-844. PMID: 29373270.
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    6. Muñoz-Torrero D, Mangoni AA, Guillou C, Collina S, Vanden Eynde JJ, Rautio J, Keseru GM, Hulme C, Chibale K, Luque FJ, Karaman R, Gütschow M, Liu H, Ragno R. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes. Molecules. 2017 May 05; 22(5). PMID: 28475136.
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    7. Paquet T, Le Manach C, Cabrera DG, Younis Y, Henrich PP, Abraham TS, Lee MCS, Basak R, Ghidelli-Disse S, Lafuente-Monasterio MJ, Bantscheff M, Ruecker A, Blagborough AM, Zakutansky SE, Zeeman AM, White KL, Shackleford DM, Mannila J, Morizzi J, Scheurer C, Angulo-Barturen I, Martínez MS, Ferrer S, Sanz LM, Gamo FJ, Reader J, Botha M, Dechering KJ, Sauerwein RW, Tungtaeng A, Vanachayangkul P, Lim CS, Burrows J, Witty MJ, Marsh KC, Bodenreider C, Rochford R, Solapure SM, Jiménez-Díaz MB, Wittlin S, Charman SA, Donini C, Campo B, Birkholtz LM, Hanson KK, Drewes G, Kocken CHM, Delves MJ, Leroy D, Fidock DA, Waterson D, Street LJ, Chibale K. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med. 2017 04 26; 9(387). PMID: 28446690.
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    8. Bowles S, Joubert E, de Beer D, Louw J, Brunschwig C, Njoroge M, Lawrence N, Wiesner L, Chibale K, Muller C. Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin. Molecules. 2017 Mar 30; 22(4). PMID: 28358310.
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    9. Cheuka PM, Mayoka G, Mutai P, Chibale K. The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases. Molecules. 2016 Dec 31; 22(1). PMID: 28042865.
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    10. Dambuza NS, Smith P, Evans A, Norman J, Taylor D, Andayi A, Egan T, Chibale K, Wiesner L. Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model. Malar J. 2015 Dec 16; 14:505. PMID: 26671222.
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    11. van der Westhuyzen R, Winks S, Wilson CR, Boyle GA, Gessner RK, Soares de Melo C, Taylor D, de Kock C, Njoroge M, Brunschwig C, Lawrence N, Rao SP, Sirgel F, van Helden P, Seldon R, Moosa A, Warner DF, Arista L, Manjunatha UH, Smith PW, Street LJ, Chibale K. Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration. J Med Chem. 2015 Dec 10; 58(23):9371-81. PMID: 26551248.
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    12. Okombo J, Chibale K. Antiplasmodial drug targets: a patent review (2000 - 2013). Expert Opin Ther Pat. 2016; 26(1):107-30. PMID: 26566576.
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    13. Le Manach C, Paquet T, Brunschwig C, Njoroge M, Han Z, Gonzàlez Cabrera D, Bashyam S, Dhinakaran R, Taylor D, Reader J, Botha M, Churchyard A, Lauterbach S, Coetzer TL, Birkholtz LM, Meister S, Winzeler EA, Waterson D, Witty MJ, Wittlin S, Jiménez-Díaz MB, Santos Martínez M, Ferrer S, Angulo-Barturen I, Street LJ, Chibale K. A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines. J Med Chem. 2015 Nov 12; 58(21):8713-22. PMID: 26502160.
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    14. Soares de Melo C, Candice Sde M, Feng TS, van der Westhuyzen R, Gessner RK, Street LJ, Morgans GL, Warner DF, Moosa A, Naran K, Lawrence N, Boshoff HI, Barry CE, Harris CJ, Gordon R, Chibale K. Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization. Bioorg Med Chem. 2015 Nov 15; 23(22):7240-50. PMID: 26522089.
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    15. Gonzàlez Cabrera D, Douelle F, Le Manach C, Han Z, Paquet T, Taylor D, Njoroge M, Lawrence N, Wiesner L, Waterson D, Witty MJ, Wittlin S, Street LJ, Chibale K. Structure-Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines. J Med Chem. 2015 Sep 24; 58(18):7572-9. PMID: 26322748.
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    16. Ongarora DS, Strydom N, Wicht K, Njoroge M, Wiesner L, Egan TJ, Wittlin S, Jurva U, Masimirembwa CM, Chibale K. Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies. Bioorg Med Chem. 2015 Sep 01; 23(17):5419-32. PMID: 26264839.
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    17. Kaur H, Machado M, de Kock C, Smith P, Chibale K, Prudêncio M, Singh K. Primaquine-pyrimidine hybrids: synthesis and dual-stage antiplasmodial activity. Eur J Med Chem. 2015 Aug 28; 101:266-73. PMID: 26142491.
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    18. Kaur H, Balzarini J, de Kock C, Smith PJ, Chibale K, Singh K. Synthesis, antiplasmodial activity and mechanistic studies of pyrimidine-5-carbonitrile and quinoline hybrids. Eur J Med Chem. 2015 Aug 28; 101:52-62. PMID: 26114811.
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    19. Njaria PM, Okombo J, Njuguna NM, Chibale K. Chloroquine-containing compounds: a patent review (2010 - 2014). Expert Opin Ther Pat. 2015; 25(9):1003-24. PMID: 26013494.
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    20. Chopra R, de Kock C, Smith P, Chibale K, Singh K. Ferrocene-pyrimidine conjugates: Synthesis, electrochemistry, physicochemical properties and antiplasmodial activities. Eur J Med Chem. 2015 Jul 15; 100:1-9. PMID: 26057222.
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    21. Chibale K. New developments in antiinfectives research for tropical infectious diseases. Bioorg Med Chem. 2015 Aug 15; 23(16):5085-6. PMID: 26014483.
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    22. Mutai P, Pavadai E, Wiid I, Ngwane A, Baker B, Chibale K. Synthesis, antimycobacterial evaluation and pharmacophore modeling of analogues of the natural product formononetin. Bioorg Med Chem Lett. 2015 Jun 15; 25(12):2510-3. PMID: 25977095.
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    23. Dambuza N, Smith P, Evans A, Taylor D, Chibale K, Wiesner L. A Pharmacokinetic Study of Antimalarial 3,5-Diaryl-2-aminopyridine Derivatives. Malar Res Treat. 2015; 2015:405962. PMID: 25893131.
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    24. Adams M, de Kock C, Smith PJ, Land KM, Liu N, Hopper M, Hsiao A, Burgoyne AR, Stringer T, Meyer M, Wiesner L, Chibale K, Smith GS. Improved antiparasitic activity by incorporation of organosilane entities into half-sandwich ruthenium(II) and rhodium(III) thiosemicarbazone complexes. Dalton Trans. 2015 Feb 07; 44(5):2456-68. PMID: 25559246.
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    25. Vandekerckhove S, Van Herreweghe S, Willems J, Danneels B, Desmet T, de Kock C, Smith PJ, Chibale K, D'hooghe M. Synthesis of functionalized 3-, 5-, 6- and 8-aminoquinolines via intermediate (3-pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines and evaluation of their antiplasmodial and antifungal activity. Eur J Med Chem. 2015 Mar 06; 92:91-102. PMID: 25544689.
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    26. Sharma RK, Younis Y, Mugumbate G, Njoroge M, Gut J, Rosenthal PJ, Chibale K. Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2. Eur J Med Chem. 2015 Jan 27; 90:507-18. PMID: 25486422.
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    27. Le Manach C, Paquet T, Gonzàlez Cabrera D, Younis Y, Taylor D, Wiesner L, Lawrence N, Schwager S, Waterson D, Witty MJ, Wittlin S, Street LJ, Chibale K. Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library: part 2. J Med Chem. 2014 Nov 13; 57(21):8839-48. PMID: 25313449.
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    28. Cheuka PM, Cabrera DG, Paquet T, Chibale K. Structure-activity relationship studies of antiplasmodial aminomethylthiazoles. Bioorg Med Chem Lett. 2014 Nov 15; 24(22):5207-11. PMID: 25316314.
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    29. Thelingwani R, Bonn B, Chibale K, Masimirembwa C. Physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid molecules with antimalarial activity. Expert Opin Drug Metab Toxicol. 2014 Oct; 10(10):1313-24. PMID: 25219629.
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    30. Njoroge M, Njuguna NM, Mutai P, Ongarora DS, Smith PW, Chibale K. Recent approaches to chemical discovery and development against malaria and the neglected tropical diseases human African trypanosomiasis and schistosomiasis. Chem Rev. 2014 Nov 26; 114(22):11138-63. PMID: 25014712.
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    31. Burger D, Reudelhuber TL, Mahajan A, Chibale K, Sturrock ED, Touyz RM. Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension. Clin Sci (Lond). 2014 Jul; 127(1):57-63. PMID: 24506807.
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    32. Kigondu EM, Wasuna A, Warner DF, Chibale K. Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery. Bioorg Med Chem. 2014 Aug 15; 22(16):4453-61. PMID: 24997576.
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    33. Andayi WA, Egan TJ, Chibale K. Kojic acid derived hydroxypyridinone-chloroquine hybrids: synthesis, crystal structure, antiplasmodial activity and ß-haematin inhibition. Bioorg Med Chem Lett. 2014 Aug 01; 24(15):3263-7. PMID: 24974345.
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    34. Singh K, Kumar M, Pavadai E, Naran K, Warner DF, Ruminski PG, Chibale K. Synthesis of new verapamil analogues and their evaluation in combination with rifampicin against Mycobacterium tuberculosis and molecular docking studies in the binding site of efflux protein Rv1258c. Bioorg Med Chem Lett. 2014 Jul 15; 24(14):2985-90. PMID: 24894561.
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    35. Le Manach C, Gonzàlez Cabrera D, Douelle F, Nchinda AT, Younis Y, Taylor D, Wiesner L, White KL, Ryan E, March C, Duffy S, Avery VM, Waterson D, Witty MJ, Wittlin S, Charman SA, Street LJ, Chibale K. Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1. J Med Chem. 2014 Mar 27; 57(6):2789-98. PMID: 24568587.
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    36. Denti P, Sharp SK, Kröger WL, Schwager SL, Mahajan A, Njoroge M, Gibhard L, Smit I, Chibale K, Wiesner L, Sturrock ED, Davies NH. Pharmacokinetic evaluation of lisinopril-tryptophan, a novel C-domain ACE inhibitor. Eur J Pharm Sci. 2014 Jun 02; 56:113-9. PMID: 24561703.
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    37. Douglas RG, Sharma RK, Masuyer G, Lubbe L, Zamora I, Acharya KR, Chibale K, Sturrock ED. Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors. Clin Sci (Lond). 2014 Feb; 126(4):305-13. PMID: 24015848.
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    38. Abay ET, van der Westhuizen JH, Swart KJ, Gibhard L, Tukulula M, Chibale K, Wiesner L. The development and validation of an LC-MS/MS method for the determination of a new anti-malarial compound (TK900D) in human whole blood and its application to pharmacokinetic studies in mice. Malar J. 2014 Jan 31; 13:42. PMID: 24484513.
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    39. González Cabrera D, Le Manach C, Douelle F, Younis Y, Feng TS, Paquet T, Nchinda AT, Street LJ, Taylor D, de Kock C, Wiesner L, Duffy S, White KL, Zabiulla KM, Sambandan Y, Bashyam S, Waterson D, Witty MJ, Charman SA, Avery VM, Wittlin S, Chibale K. 2,4-Diaminothienopyrimidines as orally active antimalarial agents. J Med Chem. 2014 Feb 13; 57(3):1014-22. PMID: 24446664.
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    40. Chellan P, Land KM, Shokar A, Au A, An SH, Taylor D, Smith PJ, Riedel T, Dyson PJ, Chibale K, Smith GS. Synthesis and evaluation of new polynuclear organometallic Ru(II), Rh(III) and Ir(III) pyridyl ester complexes as in vitro antiparasitic and antitumor agents. Dalton Trans. 2014 Jan 14; 43(2):513-26. PMID: 24121555.
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    41. Vandekerckhove S, Desmet T, Tran HG, de Kock C, Smith PJ, Chibale K, D'hooghe M. Synthesis of halogenated 4-quinolones and evaluation of their antiplasmodial activity. Bioorg Med Chem Lett. 2014 Feb 15; 24(4):1214-7. PMID: 24468411.
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    42. Hooft van Huijsduijnen R, Guy RK, Chibale K, Haynes RK, Peitz I, Kelter G, Phillips MA, Vennerstrom JL, Yuthavong Y, Wells TN. Anticancer properties of distinct antimalarial drug classes. PLoS One. 2013; 8(12):e82962. PMID: 24391728.
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    43. Singh K, Kaur H, Smith P, de Kock C, Chibale K, Balzarini J. Quinoline-pyrimidine hybrids: synthesis, antiplasmodial activity, SAR, and mode of action studies. J Med Chem. 2014 Jan 23; 57(2):435-48. PMID: 24354322.
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    44. Mjambili F, Njoroge M, Naran K, De Kock C, Smith PJ, Mizrahi V, Warner D, Chibale K. Synthesis and biological evaluation of 2-aminothiazole derivatives as antimycobacterial and antiplasmodial agents. Bioorg Med Chem Lett. 2014 Jan 15; 24(2):560-4. PMID: 24373723.
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    45. Le Manach C, Scheurer C, Sax S, Schleiferböck S, Cabrera DG, Younis Y, Paquet T, Street L, Smith P, Ding XC, Waterson D, Witty MJ, Leroy D, Chibale K, Wittlin S. Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum. Malar J. 2013 Nov 16; 12:424. PMID: 24237770.
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    46. Vial H, Taramelli D, Boulton IC, Ward SA, Doerig C, Chibale K. CRIMALDDI: platform technologies and novel anti-malarial drug targets. Malar J. 2013 Nov 05; 12:396. PMID: 24498961.
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    47. Younis Y, Douelle F, González Cabrera D, Le Manach C, Nchinda AT, Paquet T, Street LJ, White KL, Zabiulla KM, Joseph JT, Bashyam S, Waterson D, Witty MJ, Wittlin S, Charman SA, Chibale K. Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity. J Med Chem. 2013 Nov 14; 56(21):8860-71. PMID: 24099149.
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    48. Mugumbate G, Newton AS, Rosenthal PJ, Gut J, Moreira R, Chibale K, Guedes RC. Novel anti-plasmodial hits identified by virtual screening of the ZINC database. J Comput Aided Mol Des. 2013 Oct; 27(10):859-71. PMID: 24158745.
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    49. Tukulula M, Njoroge M, Abay ET, Mugumbate GC, Wiesner L, Taylor D, Gibhard L, Norman J, Swart KJ, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Kameni-Tcheudji J, Chibale K. Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds. ACS Med Chem Lett. 2013 Dec 12; 4(12):1198-202. PMID: 24900630.
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    50. Younis Y, Street LJ, Waterson D, Witty MJ, Chibale K. Cell-based medicinal chemistry optimization of high throughput screening hits for orally active antimalarials. Part 2: hits from SoftFocus kinase and other libraries. J Med Chem. 2013 Oct 24; 56(20):7750-4. PMID: 23927599.
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    51. Tukulula M, Njoroge M, Mugumbate GC, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Heudi O, Kameni-Tcheudji J, Chibale K. Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents. Bioorg Med Chem. 2013 Sep 01; 21(17):4904-13. PMID: 23896611.
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    52. Singh K, Kaur H, Chibale K, Balzarini J. Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies. Eur J Med Chem. 2013 Aug; 66:314-23. PMID: 23811093.
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    53. Njogu PM, Gut J, Rosenthal PJ, Chibale K. Design, Synthesis, and Antiplasmodial Activity of Hybrid Compounds Based on (2R,3S)-N-Benzoyl-3-phenylisoserine. ACS Med Chem Lett. 2013 Jul 11; 4(7):637-41. PMID: 24900723.
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    54. Andayi WA, Egan TJ, Gut J, Rosenthal PJ, Chibale K. Synthesis, Antiplasmodial Activity, and ß-Hematin Inhibition of Hydroxypyridone-Chloroquine Hybrids. ACS Med Chem Lett. 2013 Jul 11; 4(7):642-6. PMID: 24900724.
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    55. Nsumiwa S, Kuter D, Wittlin S, Chibale K, Egan TJ. Structure-activity relationships for ferriprotoporphyrin IX association and ß-hematin inhibition by 4-aminoquinolines using experimental and ab initio methods. Bioorg Med Chem. 2013 Jul 01; 21(13):3738-48. PMID: 23669191.
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    56. Adams M, Li Y, Khot H, De Kock C, Smith PJ, Land K, Chibale K, Smith GS. The synthesis and antiparasitic activity of aryl- and ferrocenyl-derived thiosemicarbazone ruthenium(II)-arene complexes. Dalton Trans. 2013 Apr 07; 42(13):4677-85. PMID: 23361649.
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    57. Chigorimbo-Murefu NT, Njoroge M, Louw S, Mugumbate G, Chibale K. Drug metabolite generation using a laboratory evolved NADPH independent cytochrome P450: application of in vitro and in silico approaches. Drug Metab Lett. 2013 Mar; 7(1):68-77. PMID: 23957950.
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    58. Espinoza-Moraga M, Njuguna NM, Mugumbate G, Caballero J, Chibale K. In silico comparison of antimycobacterial natural products with known antituberculosis drugs. J Chem Inf Model. 2013 Mar 25; 53(3):649-60. PMID: 23410241.
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    59. Njogu PM, Chibale K. Recent developments in rationally designed multitarget antiprotozoan agents. Curr Med Chem. 2013; 20(13):1715-42. PMID: 23410169.
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    60. D'hooghe M, Vervisch K, Törnroos KW, Verhaeghe T, Desmet T, Lategan C, Smith PJ, Chibale K, De Kimpe N. Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH4-induced reductive cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl)aziridines and evaluation of their antimalarial activity. Bioorg Med Chem Lett. 2013 Mar 01; 23(5):1507-10. PMID: 23347684.
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    61. González Cabrera D, Douelle F, Younis Y, Feng TS, Le Manach C, Nchinda AT, Street LJ, Scheurer C, Kamber J, White KL, Montagnat OD, Ryan E, Katneni K, Zabiulla KM, Joseph JT, Bashyam S, Waterson D, Witty MJ, Charman SA, Wittlin S, Chibale K. Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines. J Med Chem. 2012 Dec 27; 55(24):11022-30. PMID: 23189922.
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    62. Paquet T, Gordon R, Waterson D, Witty MJ, Chibale K. Antimalarial aminothiazoles and aminopyridines from phenotypic whole-cell screening of a SoftFocus(®) library. Future Med Chem. 2012 Dec; 4(18):2265-77. PMID: 23234550.
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    63. Chigorimbo-Murefu NT, Njoroge M, Nzila A, Louw S, Masimirembwa C, Chibale K. Biotransformation and biocatalysis: roles and applications in the discovery of antimalarials. Future Med Chem. 2012 Dec; 4(18):2325-36. PMID: 23234554.
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    64. Tukulula M, Sharma RK, Meurillon M, Mahajan A, Naran K, Warner D, Huang J, Mekonnen B, Chibale K. Synthesis and antiplasmodial and antimycobacterial evaluation of new nitroimidazole and nitroimidazooxazine derivatives. ACS Med Chem Lett. 2013 Jan 10; 4(1):128-31. PMID: 24900574.
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    65. Vandekerckhove S, Müller C, Vogt D, Lategan C, Smith PJ, Chibale K, De Kimpe N, D'hooghe M. Synthesis and antiplasmodial evaluation of novel (4-aminobutyloxy)quinolines. Bioorg Med Chem Lett. 2013 Jan 01; 23(1):318-22. PMID: 23195733.
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    66. Louw S, Njoroge M, Chigorimbo-Murefu N, Chibale K. Comparison of electrospray ionisation, atmospheric pressure chemical ionisation and atmospheric pressure photoionisation for the identification of metabolites from labile artemisinin-based anti-malarial drugs using a QTRAP® mass spectrometer. Rapid Commun Mass Spectrom. 2012 Oct 30; 26(20):2431-42. PMID: 22976210.
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    67. Njuguna NM, Ongarora DS, Chibale K. Artemisinin derivatives: a patent review (2006 - present). Expert Opin Ther Pat. 2012 Oct; 22(10):1179-203. PMID: 22971128.
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    68. Tukulula M, Little S, Gut J, Rosenthal PJ, Wan B, Franzblau SG, Chibale K. The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives. Eur J Med Chem. 2012 Nov; 57:259-67. PMID: 23064162.
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    69. Aminake MN, Mahajan A, Kumar V, Hans R, Wiesner L, Taylor D, de Kock C, Grobler A, Smith PJ, Kirschner M, Rethwilm A, Pradel G, Chibale K. Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy. Bioorg Med Chem. 2012 Sep 01; 20(17):5277-89. PMID: 22858300.
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    70. Ongarora DS, Gut J, Rosenthal PJ, Masimirembwa CM, Chibale K. Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation. Bioorg Med Chem Lett. 2012 Aug 01; 22(15):5046-50. PMID: 22749280.
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    71. Sharma RK, Douglas RG, Louw S, Chibale K, Sturrock ED. New ketomethylene inhibitor analogues: synthesis and assessment of structural determinants for N-domain selective inhibition of angiotensin-converting enzyme. Biol Chem. 2012 May; 393(6):485-93. PMID: 22628311.
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    72. Thelingwani RS, Dhansay K, Smith P, Chibale K, Masimirembwa CM. Potent inhibition of CYP1A2 by Frutinone A, an active ingredient of the broad spectrum antimicrobial herbal extract from P. fruticosa. Xenobiotica. 2012 Oct; 42(10):989-1000. PMID: 22533317.
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    73. Younis Y, Douelle F, Feng TS, González Cabrera D, Le Manach C, Nchinda AT, Duffy S, White KL, Shackleford DM, Morizzi J, Mannila J, Katneni K, Bhamidipati R, Zabiulla KM, Joseph JT, Bashyam S, Waterson D, Witty MJ, Hardick D, Wittlin S, Avery V, Charman SA, Chibale K. 3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential. J Med Chem. 2012 Apr 12; 55(7):3479-87. PMID: 22390538.
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    74. Geary TG, Chibale K, Abegaz B, Andrae-Marobela K, Ubalijoro E. A new approach for anthelmintic discovery for humans. Trends Parasitol. 2012 May; 28(5):176-81. PMID: 22424638.
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    75. Singh K, Kaur H, Chibale K, Balzarini J, Little S, Bharatam PV. 2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies. Eur J Med Chem. 2012 Jun; 52:82-97. PMID: 22459876.
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    77. Kobarfard F, Yardley V, Little S, Daryaee F, Chibale K. Synthesis of aminoquinoline-based aminoalcohols and oxazolidinones and their antiplasmodial activity. Chem Biol Drug Des. 2012 Mar; 79(3):326-31. PMID: 22129095.
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    78. D'hooghe M, Vandekerckhove S, Mollet K, Vervisch K, Dekeukeleire S, Lehoucq L, Lategan C, Smith PJ, Chibale K, De Kimpe N. Synthesis of 2-amino-3-arylpropan-1-ols and 1-(2,3-diaminopropyl)-1,2,3-triazoles and evaluation of their antimalarial activity. Beilstein J Org Chem. 2011; 7:1745-52. PMID: 22238554.
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    79. Tacon C, Guantai EM, Smith PJ, Chibale K. Synthesis, biological evaluation and mechanistic studies of totarol amino alcohol derivatives as potential antimalarial agents. Bioorg Med Chem. 2012 Jan 15; 20(2):893-902. PMID: 22196513.
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    80. Domingo R, Chibale K, Sturrock ED. The significance of the C(a) substituent in the selective inhibition of matrix metalloproteinases 1 and 9. Biol Chem. 2011 Nov; 392(11):1003-10. PMID: 21972974.
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    81. González Cabrera D, Douelle F, Feng TS, Nchinda AT, Younis Y, White KL, Wu Q, Ryan E, Burrows JN, Waterson D, Witty MJ, Wittlin S, Charman SA, Chibale K. Novel orally active antimalarial thiazoles. J Med Chem. 2011 Nov 10; 54(21):7713-9. PMID: 21966980.
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    82. Zishiri VK, Joshi MC, Hunter R, Chibale K, Smith PJ, Summers RL, Martin RE, Egan TJ. Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT). J Med Chem. 2011 Oct 13; 54(19):6956-68. PMID: 21875063.
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    83. Nzila A, Ma Z, Chibale K. Drug repositioning in the treatment of malaria and TB. Future Med Chem. 2011 Sep; 3(11):1413-26. PMID: 21879845.
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    84. Chellan P, Stringer T, Shokar A, Dornbush PJ, Vazquez-Anaya G, Land KM, Chibale K, Smith GS. Synthesis and in vitro evaluation of palladium(II) salicylaldiminato thiosemicarbazone complexes against Trichomonas vaginalis. J Inorg Biochem. 2011 Dec; 105(12):1562-8. PMID: 22071079.
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    85. Ndakala AJ, Gessner RK, Gitari PW, October N, White KL, Hudson A, Fakorede F, Shackleford DM, Kaiser M, Yeates C, Charman SA, Chibale K. Antimalarial pyrido[1,2-a]benzimidazoles. J Med Chem. 2011 Jul 14; 54(13):4581-9. PMID: 21644541.
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    86. Singh P, Sachdeva S, Raj R, Kumar V, Mahajan MP, Nasser S, Vivas L, Gut J, Rosenthal PJ, Feng TS, Chibale K. Antiplasmodial and cytotoxicity evaluation of 3-functionalized 2-azetidinone derivatives. Bioorg Med Chem Lett. 2011 Aug 01; 21(15):4561-3. PMID: 21705220.
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    87. Feng TS, Guantai EM, Nell M, van Rensburg CE, Ncokazi K, Egan TJ, Hoppe HC, Chibale K. Effects of highly active novel artemisinin-chloroquinoline hybrid compounds on ß-hematin formation, parasite morphology and endocytosis in Plasmodium falciparum. Biochem Pharmacol. 2011 Aug 01; 82(3):236-47. PMID: 21596024.
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    88. Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Bhampidipati R, Kopinathan A, Smith PJ, Chibale K. Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies. J Med Chem. 2011 May 26; 54(10):3637-49. PMID: 21500839.
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    89. Feng TS, Guantai EM, Nell MJ, van Rensburg CE, Hoppe HC, Chibale K. Antiplasmodial and antitumor activity of dihydroartemisinin analogs derived via the aza-Michael addition reaction. Bioorg Med Chem Lett. 2011 May 15; 21(10):2882-6. PMID: 21489789.
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    90. Mahajan A, Kremer L, Louw S, Guérardel Y, Guéradel Y, Chibale K, Biot C. Synthesis and in vitro antitubercular activity of ferrocene-based hydrazones. Bioorg Med Chem Lett. 2011 May 15; 21(10):2866-8. PMID: 21507641.
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    91. Singh K, Singh K, Wan B, Franzblau S, Chibale K, Balzarini J. Facile transformation of Biginelli pyrimidin-2(1H)-ones to pyrimidines. In vitro evaluation as inhibitors of Mycobacterium tuberculosis and modulators of cytostatic activity. Eur J Med Chem. 2011 Jun; 46(6):2290-4. PMID: 21450375.
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    92. Guantai E, Chibale K. How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials? Malar J. 2011 Mar 15; 10 Suppl 1:S2. PMID: 21411013.
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    93. Hans RH, Wiid IJ, van Helden PD, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents. Bioorg Med Chem Lett. 2011 Apr 01; 21(7):2055-8. PMID: 21376591.
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    94. Chibale K, Guantai EM, Masimirembwa C. Extracting molecular information from African natural products to facilitate unique African-led drug-discovery efforts. Future Med Chem. 2011 Mar; 3(3):257-61. PMID: 21446839.
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    95. Kuter D, Chibale K, Egan TJ. Linear free energy relationships predict coordination and p-stacking interactions of small molecules with ferriprotoporphyrin IX. J Inorg Biochem. 2011 May; 105(5):684-92. PMID: 21450272.
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    96. Burrows JN, Chibale K, Wells TN. The state of the art in anti-malarial drug discovery and development. Curr Top Med Chem. 2011; 11(10):1226-54. PMID: 21401508.
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    97. D'hooghe M, Kenis S, Vervisch K, Lategan C, Smith PJ, Chibale K, De Kimpe N. Synthesis of 2-(aminomethyl)aziridines and their microwave-assisted ring opening to 1,2,3-triaminopropanes as novel antimalarial pharmacophores. Eur J Med Chem. 2011 Feb; 46(2):579-87. PMID: 21183259.
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    98. Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Smith PJ, Chibale K. Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds. Bioorg Med Chem. 2010 Dec 01; 18(23):8243-56. PMID: 21044845.
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    99. Guantai E, Chibale K. Chloroquine resistance: proposed mechanisms and countermeasures. Curr Drug Deliv. 2010 Oct; 7(4):312-23. PMID: 20695842.
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    100. Hans RH, Su H, Chibale K. Novel tetracyclic structures from the synthesis of thiolactone-isatin hybrids. Beilstein J Org Chem. 2010 Jul 19; 6. PMID: 20703386.
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    101. Boulton IC, Nwaka S, Bathurst I, Lanzer M, Taramelli D, Vial H, Doerig C, Chibale K, Ward SA. CRIMALDDI: a co-ordinated, rational, and integrated effort to set logical priorities in anti-malarial drug discovery initiatives. Malar J. 2010 Jul 13; 9:202. PMID: 20626844.
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    102. Khanye SD, Smith GS, Lategan C, Smith PJ, Gut J, Rosenthal PJ, Chibale K. Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity. J Inorg Biochem. 2010 Oct; 104(10):1079-83. PMID: 20621360.
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    103. Hans RH, Gut J, Rosenthal PJ, Chibale K. Comparison of the antiplasmodial and falcipain-2 inhibitory activity of beta-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids. Bioorg Med Chem Lett. 2010 Apr 01; 20(7):2234-7. PMID: 20206517.
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    104. Khanye SD, Báthori NB, Smith GS, Chibale K. Gold(I) derived thiosemicarbazone complexes with rare halogen-halogen interaction-reduction of [Au(damp-C1,N)Cl2]. Dalton Trans. 2010 Mar 14; 39(10):2697-700. PMID: 20179866.
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    105. Hans RH, Guantai EM, Lategan C, Smith PJ, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. Synthesis, antimalarial and antitubercular activity of acetylenic chalcones. Bioorg Med Chem Lett. 2010 Feb 01; 20(3):942-4. PMID: 20045640.
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    106. Blackie MA, Yardley V, Chibale K. Synthesis and evaluation of phenylequine for antimalarial activity in vitro and in vivo. Bioorg Med Chem Lett. 2010 Feb 01; 20(3):1078-80. PMID: 20034790.
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    107. D'hooghe M, Dekeukeleire S, Mollet K, Lategan C, Smith PJ, Chibale K, De Kimpe N. Synthesis of novel 2-alkoxy-3-amino-3-arylpropan-1-ols and 5-alkoxy-4-aryl-1,3-oxazinanes with antimalarial activity. J Med Chem. 2009 Jul 09; 52(13):4058-62. PMID: 19463002.
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    108. Stevens AT, Caira MR, Bull JR, Chibale K. Cycloaddition and one-carbon homologation studies in the synthesis of advanced iridoid precursors. Org Biomol Chem. 2009 Sep 07; 7(17):3527-36. PMID: 19675910.
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    109. Hohman M, Gregory K, Chibale K, Smith PJ, Ekins S, Bunin B. Novel web-based tools combining chemistry informatics, biology and social networks for drug discovery. Drug Discov Today. 2009 Mar; 14(5-6):261-70. PMID: 19231313.
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    110. Kumar V, Mahajan A, Chibale K. Synthetic medicinal chemistry of selected antimalarial natural products. Bioorg Med Chem. 2009 Mar 15; 17(6):2236-75. PMID: 19157883.
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    111. October N, Watermeyer ND, Yardley V, Egan TJ, Ncokazi K, Chibale K. Reversed chloroquines based on the 3,4-dihydropyrimidin-2(1H)-one scaffold: synthesis and evaluation for antimalarial, beta-haematin inhibition, and cytotoxic activity. ChemMedChem. 2008 Nov; 3(11):1649-53. PMID: 18846586.
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    112. Musonda CC, Yardley V, de Souza RC, Ncokazi K, Egan TJ, Chibale K. Antiplasmodial, beta-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines. Org Biomol Chem. 2008 Dec 07; 6(23):4446-51. PMID: 19005606.
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    113. Mahajan A, Kumar V, Mansour NR, Bickle Q, Chibale K. Meclonazepam analogues as potential new antihelmintic agents. Bioorg Med Chem Lett. 2008 Apr 01; 18(7):2333-6. PMID: 18343662.
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    114. Blackie MA, Chibale K. Metallocene antimalarials: the continuing quest. Met Based Drugs. 2008; 2008:495123. PMID: 18274662.
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    115. Stevens AT, Bull JR, Chibale K. Studies in iridoid synthesis. Chemoselective transformations of cis-1,2,4,6-tetrahydrophthalic anhydride. Org Biomol Chem. 2008 Feb 07; 6(3):586-95. PMID: 18219431.
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    116. Biot C, Pradines B, Sergeant MH, Gut J, Rosenthal PJ, Chibale K. Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues. Bioorg Med Chem Lett. 2007 Dec 01; 17(23):6434-8. PMID: 17949976.
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    117. Mahajan A, Yeh S, Nell M, van Rensburg CE, Chibale K. Synthesis of new 7-chloroquinolinyl thioureas and their biological investigation as potential antimalarial and anticancer agents. Bioorg Med Chem Lett. 2007 Oct 15; 17(20):5683-5. PMID: 17768052.
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    118. Blackie MA, Beagley P, Croft SL, Kendrick H, Moss JR, Chibale K. Metallocene-based antimalarials: an exploration into the influence of the ferrocenyl moiety on in vitro antimalarial activity in chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. Bioorg Med Chem. 2007 Oct 15; 15(20):6510-6. PMID: 17693090.
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    119. Musonda CC, Little S, Yardley V, Chibale K. Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro. Bioorg Med Chem Lett. 2007 Sep 01; 17(17):4733-6. PMID: 17644333.
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    120. Pillay P, Vleggaar R, Maharaj VJ, Smith PJ, Lategan CA, Chouteau F, Chibale K. Antiplasmodial hirsutinolides from Vernonia staehelinoides and their utilization towards a simplified pharmacophore. Phytochemistry. 2007 Apr; 68(8):1200-5. PMID: 17408709.
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    121. Ott R, Chibale K, Anderson S, Chipeleme A, Chaudhuri M, Guerrah A, Colowick N, Hill GC. Novel inhibitors of the trypanosome alternative oxidase inhibit Trypanosoma brucei brucei growth and respiration. Acta Trop. 2006 Dec; 100(3):172-84. PMID: 17126803.
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    122. Mbewe B, Chibale K, McIntosh DB. Purification of human malaria parasite hypoxanthine guanine xanthine phosphoribosyltransferase (HGXPRT) using immobilized Reactive Red 120. Protein Expr Purif. 2007 Mar; 52(1):153-8. PMID: 17097304.
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    123. Chipeleme A, Gut J, Rosenthal PJ, Chibale K. Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum. Bioorg Med Chem. 2007 Jan 01; 15(1):273-82. PMID: 17052908.
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    124. Nchinda AT, Chibale K, Redelinghuys P, Sturrock ED. Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors. Bioorg Med Chem Lett. 2006 Sep 01; 16(17):4612-5. PMID: 16784850.
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    125. Nchinda AT, Chibale K, Redelinghuys P, Sturrock ED. Synthesis and molecular modeling of a lisinopril-tryptophan analogue inhibitor of angiotensin I-converting enzyme. Bioorg Med Chem Lett. 2006 Sep 01; 16(17):4616-9. PMID: 16784843.
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    126. Biot C, Chibale K. Novel approaches to antimalarial drug discovery. Infect Disord Drug Targets. 2006 Jun; 6(2):173-204. PMID: 16789878.
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    127. Musonda CC, Gut J, Rosenthal PJ, Yardley V, Carvalho de Souza RC, Chibale K. Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol. Bioorg Med Chem. 2006 Aug 15; 14(16):5605-15. PMID: 16690319.
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    128. Yeh S, Smith PJ, Chibale K. Dual-acting diamine antiplasmodial and chloroquine resistance modulating agents. Biochem Pharmacol. 2006 Jul 14; 72(2):156-65. PMID: 16730664.
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    129. Redelinghuys P, Nchinda AT, Chibale K, Sturrock ED. Novel ketomethylene inhibitors of angiotensin I-converting enzyme (ACE): inhibition and molecular modelling. Biol Chem. 2006 Apr; 387(4):461-6. PMID: 16606345.
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    130. Molyneaux CA, Krugliak M, Ginsburg H, Chibale K. Arylpiperazines displaying preferential potency against chloroquine-resistant strains of the malaria parasite Plasmodium falciparum. Biochem Pharmacol. 2005 Dec 19; 71(1-2):61-8. PMID: 16298348.
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    131. Wu CP, van Schalkwyk DA, Taylor D, Smith PJ, Chibale K. Reversal of chloroquine resistance in Plasmodium falciparum by 9H-xanthene derivatives. Int J Antimicrob Agents. 2005 Aug; 26(2):170-5. PMID: 16009536.
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    132. Chouteau F, Ramanitrahasimbola D, Rasoanaivo P, Chibale K. Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites. Bioorg Med Chem Lett. 2005 Jun 15; 15(12):3024-8. PMID: 15908208.
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    133. Chiyanzu I, Clarkson C, Smith PJ, Lehman J, Gut J, Rosenthal PJ, Chibale K. Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives. Bioorg Med Chem. 2005 May 02; 13(9):3249-61. PMID: 15809160.
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    134. Staines HM, Ellory JC, Chibale K. The new permeability pathways: targets and selective routes for the development of new antimalarial agents. Comb Chem High Throughput Screen. 2005 Feb; 8(1):81-8. PMID: 15720199.
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    135. Musonda CC, Chibale K. Application of combinatorial and parallel synthesis chemistry methodologies to antiparasitic drug discovery. Curr Med Chem. 2004 Oct; 11(19):2519-33. PMID: 15544460.
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    136. Musonda CC, Taylor D, Lehman J, Gut J, Rosenthal PJ, Chibale K. Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts. Bioorg Med Chem Lett. 2004 Aug 02; 14(15):3901-5. PMID: 15225694.
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    137. Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem. 2004 Jun 03; 47(12):3212-9. PMID: 15163200.
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    138. Chiyanzu I, Hansell E, Gut J, Rosenthal PJ, McKerrow JH, Chibale K. Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett. 2003 Oct 20; 13(20):3527-30. PMID: 14505663.
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    139. Clarkson C, Musonda CC, Chibale K, Campbell WE, Smith P. Synthesis of totarol amino alcohol derivatives and their antiplasmodial activity and cytotoxicity. Bioorg Med Chem. 2003 Oct 01; 11(20):4417-22. PMID: 13129578.
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    140. Chibale K, Musonda CC. The synthesis of parasitic cysteine protease and trypanothione reductase inhibitors. Curr Med Chem. 2003 Sep; 10(18):1863-89. PMID: 12871109.
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    141. Chibale K. A chemical approach towards understanding the mechanism and reversal of drug resistance in Plasmodium falciparum: is it viable? IUBMB Life. 2002 Apr-May; 53(4-5):249-52. PMID: 12121004.
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    142. Chibale K, Haupt H, Kendrick H, Yardley V, Saravanamuthu A, Fairlamb AH, Croft SL. Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine. Bioorg Med Chem Lett. 2001 Oct 08; 11(19):2655-7. PMID: 11551771.
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    143. Chibale K, Ojima I, Haupt H, Geng X, Pera P, Bernacki RJ. Modulation of human mammary cell sensitivity to paclitaxel by new quinoline sulfonamides. Bioorg Med Chem Lett. 2001 Sep 17; 11(18):2457-60. PMID: 11549446.
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    144. Chibale K, Visser M, Yardley V, Croft SL, Fairlamb AH. Synthesis and evaluation of 9,9-dimethylxanthene tricyclics against trypanothione reductase, Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani. Bioorg Med Chem Lett. 2000 Jun 05; 10(11):1147-50. PMID: 10866368.
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    145. Nicolaou KC, Trujillo JI, Jandeleit B, Chibale K, Rosenfeld M, Diefenbach B, Cheresh DA, Goodman SL. Design, synthesis and biological evaluation of nonpeptide integrin antagonists. Bioorg Med Chem. 1998 Aug; 6(8):1185-208. PMID: 9784861.
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