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Dr Dhafer Laouini

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Diouani MF, Ouerghi O, Belgacem K, Sayhi M, Ionescu R, Laouini D. Casein-Conjugated Gold Nanoparticles for Amperometric Detection of Leishmania infantum. Biosensors (Basel). 2019 May 27; 9(2). PMID: 31137793.
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    2. Guerfali FZ, Laouini D, Boudabous A, Tekaia F. Designing and running an advanced Bioinformatics and genome analyses course in Tunisia. PLoS Comput Biol. 2019 01; 15(1):e1006373. PMID: 30689625.
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    3. Welearegay TG, Diouani MF, Österlund L, Borys S, Khaled S, Smadhi H, Ionescu F, Bouchekoua M, Aloui D, Laouini D, Cindemir U, Ionescu R. Diagnosis of Human Echinococcosis via Exhaled Breath Analysis: A Promise for Rapid Diagnosis of Infectious Diseases Caused by Helminths. J Infect Dis. 2019 01 01; 219(1):101-109. PMID: 30016445.
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    4. Welearegay TG, Diouani MF, Österlund L, Ionescu F, Belgacem K, Smadhi H, Khaled S, Kidar A, Cindemir U, Laouini D, Ionescu R. Ligand-Capped Ultrapure Metal Nanoparticle Sensors for the Detection of Cutaneous Leishmaniasis Disease in Exhaled Breath. ACS Sens. 2018 12 28; 3(12):2532-2540. PMID: 30403135.
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    5. Bussotti G, Gouzelou E, Côrtes Boité M, Kherachi I, Harrat Z, Eddaikra N, Mottram JC, Antoniou M, Christodoulou V, Bali A, Guerfali FZ, Laouini D, Mukhtar M, Dumetz F, Dujardin JC, Smirlis D, Lechat P, Pescher P, El Hamouchi A, Lemrani M, Chicharro C, Llanes-Acevedo IP, Botana L, Cruz I, Moreno J, Jeddi F, Aoun K, Bouratbine A, Cupolillo E, Späth GF. Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification. mBio. 2018 11 06; 9(6). PMID: 30401775.
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    6. Atri C, Guerfali FZ, Laouini D. Role of Human Macrophage Polarization in Inflammation during Infectious Diseases. Int J Mol Sci. 2018 06 19; 19(6). PMID: 29921749.
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    7. Sayhi M, Ouerghi O, Belgacem K, Arbi M, Tepeli Y, Ghram A, Anik Ü, Österlund L, Laouini D, Diouani MF. Electrochemical detection of influenza virus H9N2 based on both immunomagnetic extraction and gold catalysis using an immobilization-free screen printed carbon microelectrode. Biosens Bioelectron. 2018 Jun 01; 107:170-177. PMID: 29455027.
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    8. Ben Ayed S, Ali MB, Bali A, Gargouri Y, Laouini D, Ben Ali Y. Secretory lipase from the human pathogen Leishmania major: Heterologous expression in the yeast Pichia pastoris and biochemical characterization. Biochimie. 2018 Mar; 146:119-126. PMID: 29246663.
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    9. Ghawar W, Pascalis H, Bettaieb J, Mélade J, Gharbi A, Snoussi MA, Laouini D, Goodman SM, Ben Salah A, Dellagi K. Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses. Sci Rep. 2017 05 16; 7(1):1974. PMID: 28512347.
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    10. Diouani MF, Ouerghi O, Refai A, Belgacem K, Tlili C, Laouini D, Essafi M. Detection of ESAT-6 by a label free miniature immuno-electrochemical biosensor as a diagnostic tool for tuberculosis. Mater Sci Eng C Mater Biol Appl. 2017 May 01; 74:465-470. PMID: 28254318.
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    11. Guerfali FZ, Lemaire J, Mkannez G, Renard P, Laouini D. Letter to the Editor: Hypoxia inducible factor 1a: A critical factor for the immune response to pathogens and Leishmania. Cell Immunol. 2016 12; 310:211. PMID: 27890115.
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    12. Ayed Y, Sghaier RM, Laouini D, Bacha H. Evaluation of anti-proliferative and anti-inflammatory activities of Pelagia noctiluca venom in Lipopolysaccharide/Interferon-? stimulated RAW264.7 macrophages. Biomed Pharmacother. 2016 Dec; 84:1986-1991. PMID: 27876211.
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    13. Ghouila A, Guerfali FZ, Atri C, Bali A, Attia H, Sghaier RM, Mkannez G, Dickens NJ, Laouini D. Comparative genomics of Tunisian Leishmania major isolates causing human cutaneous leishmaniasis with contrasting clinical severity. Infect Genet Evol. 2017 06; 50:110-120. PMID: 27818279.
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    14. Sghaier RM, Aissa I, Attia H, Bali A, Leon Martinez PA, Mkannez G, Guerfali FZ, Gargouri Y, Laouini D. Treatment with synthetic lipophilic tyrosyl ester controls Leishmania major infection by reducing parasite load in BALB/c mice. Parasitology. 2016 10; 143(12):1615-21. PMID: 27312247.
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    15. Attia H, Sghaier RM, Gelanew T, Bali A, Schweynoch C, Guerfali FZ, Mkannez G, Chlif S, Belhaj-Hamida N, Dellagi K, Schönian G, Laouini D. Genetic micro-heterogeneity of Leishmania major in emerging foci of zoonotic cutaneous leishmaniasis in Tunisia. Infect Genet Evol. 2016 09; 43:179-85. PMID: 27137082.
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    16. Bouabdallah S, Sghaier RM, Selmi S, Khlifi D, Laouini D, Ben-Attia M. Current approaches and challenges for chemical characterization of inhibitory effect against cancer cell line isolated from Gokshur extract. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jul 15; 1026:279-285. PMID: 26711680.
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    17. Ghawar W, Attia H, Bettaieb J, Yazidi R, Laouini D, Salah AB. Genotype profile of Leishmania major strains isolated from tunisian rodent reservoir hosts revealed by multilocus microsatellite typing. PLoS One. 2014; 9(9):e107043. PMID: 25203305.
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    18. Kharrat N, Aissa I, Sghaier M, Bouaziz M, Sellami M, Laouini D, Gargouri Y. Lipophilization of ascorbic acid: a monolayer study and biological and antileishmanial activities. J Agric Food Chem. 2014 Sep 17; 62(37):9118-27. PMID: 25148258.
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    19. Ghouila A, Florent I, Guerfali FZ, Terrapon N, Laouini D, Yahia SB, Gascuel O, Bréhélin L. Identification of divergent protein domains by combining HMM-HMM comparisons and co-occurrence detection. PLoS One. 2014; 9(6):e95275. PMID: 24901648.
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    20. Louzir H, Aoun K, Späth GF, Laouini D, Prina E, Victoir K, Bouratbine A. [Leishmania epidemiology, diagnosis, chemotherapy and vaccination approaches in the international network of Pasteur Institutes]. Med Sci (Paris). 2013 Dec; 29(12):1151-60. PMID: 24356147.
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    21. Lemaire J, Mkannez G, Guerfali FZ, Gustin C, Attia H, Sghaier RM. MicroRNA expression profile in human macrophages in response to Leishmania major infection. PLoS Negl Trop Dis. 2013; 7(10):e2478. PMID: 24098824.
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    22. Khlifi D, Sghaier RM, Amouri S, Laouini D, Hamdi M, Bouajila J. Composition and anti-oxidant, anti-cancer and anti-inflammatory activities of Artemisia herba-alba, Ruta chalpensis L. and Peganum harmala L. Food Chem Toxicol. 2013 May; 55:202-8. PMID: 23333573.
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    23. Smandi S, Guerfali FZ, Farhat M, Ben-Aissa K, Laouini D, Guizani-Tabbane L, Dellagi K, Benkahla A. Methodology optimizing SAGE library tag-to-gene mapping: application to Leishmania. BMC Res Notes. 2012 Jan 27; 5:74. PMID: 22283878.
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    24. Aissa I, Sghair RM, Bouaziz M, Laouini D, Sayadi S, Gargouri Y. Synthesis of lipophilic tyrosyl esters derivatives and assessment of their antimicrobial and antileishmania activities. Lipids Health Dis. 2012 Jan 20; 11:13. PMID: 22264330.
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    25. Ben Hadj Ahmed S, Kaabi B, Chelbi I, Cherni S, Derbali M, Laouini D, Zhioua E. Colonization of Phlebotomus papatasi changes the effect of pre-immunization with saliva from lack of protection towards protection against experimental challenge with Leishmania major and saliva. Parasit Vectors. 2011 Jul 04; 4:126. PMID: 21726438.
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    26. Ahmed SB, Sghaier RM, Guesmi F, Kaabi B, Mejri M, Attia H, Laouini D, Smaali I. Evaluation of antileishmanial, cytotoxic and antioxidant activities of essential oils extracted from plants issued from the leishmaniasis-endemic region of Sned (Tunisia). Nat Prod Res. 2011 Jul; 25(12):1195-201. PMID: 21740286.
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    27. Ghouila A, Terrapon N, Gascuel O, Guerfali FZ, Laouini D, Maréchal E, Bréhélin L. EuPathDomains: the divergent domain database for eukaryotic pathogens. Infect Genet Evol. 2011 Jun; 11(4):698-707. PMID: 20920608.
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    28. Ahmed SB, Kaabi B, Chelbi I, Derbali M, Cherni S, Laouini D, Zhioua E. Lack of protection of pre-immunization with saliva of long-term colonized Phlebotomus papatasi against experimental challenge with Leishmania major and saliva of wild-caught P. papatasi. Am J Trop Med Hyg. 2010 Sep; 83(3):512-4. PMID: 20810812.
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    29. Benhnini F, Chenik M, Laouini D, Louzir H, Cazenave PA, Dellagi K. Comparative evaluation of two vaccine candidates against experimental leishmaniasis due to Leishmania major infection in four inbred mouse strains. Clin Vaccine Immunol. 2009 Nov; 16(11):1529-37. PMID: 19726616.
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    30. Ghouila A, Yahia SB, Malouche D, Jmel H, Laouini D, Guerfali FZ, Abdelhak S. Application of Multi-SOM clustering approach to macrophage gene expression analysis. Infect Genet Evol. 2009 May; 9(3):328-36. PMID: 18992849.
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    31. Jabara H, Laouini D, Tsitsikov E, Mizoguchi E, Bhan A, Castigli E, Dedeoglu F, Pivniouk V, Brodeur S, Geha R. The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching. Immunity. 2002 Sep; 17(3):265-76. PMID: 12354380.
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    32. Ma W, Bryce PJ, Humbles AA, Laouini D, Yalcindag A, Alenius H, Friend DS, Oettgen HC, Gerard C, Geha RS. CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. J Clin Invest. 2002 Mar; 109(5):621-8. PMID: 11877470.
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    33. Kumar L, Pivniouk V, de la Fuente MA, Laouini D, Geha RS. Differential role of SLP-76 domains in T cell development and function. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):884-9. PMID: 11792851.
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    34. Alenius H, Laouini D, Woodward A, Mizoguchi E, Bhan AK, Castigli E, Oettgen HC, Geha RS. Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation. J Allergy Clin Immunol. 2002 Jan; 109(1):106-13. PMID: 11799374.
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    35. Tsitsikov EN, Laouini D, Dunn IF, Sannikova TY, Davidson L, Alt FW, Geha RS. TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice. Immunity. 2001 Oct; 15(4):647-57. PMID: 11672546.
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    36. Laouini D, Casrouge A, Dalle S, Lemonnier F, Kourilsky P, Kanellopoulos J. V beta T cell repertoire of CD8+ splenocytes selected on nonpolymorphic MHC class I molecules. J Immunol. 2000 Dec 01; 165(11):6381-6. PMID: 11086076.
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    37. Bousso P, Lemaître F, Laouini D, Kanellopoulos J, Kourilsky P. The peripheral CD8 T cell repertoire is largely independent of the presence of intestinal flora. Int Immunol. 2000 Apr; 12(4):425-30. PMID: 10744643.
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    38. Mémet S, Laouini D, Epinat JC, Whiteside ST, Goudeau B, Philpott D, Kayal S, Sansonetti PJ, Berche P, Kanellopoulos J, Israël A. IkappaBepsilon-deficient mice: reduction of one T cell precursor subspecies and enhanced Ig isotype switching and cytokine synthesis. J Immunol. 1999 Dec 01; 163(11):5994-6005. PMID: 10570287.
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    39. Pardigon N, Laouini D. New millenium. The need for new vaccines. C R Acad Sci III. 1999 Nov; 322(11):913-7. PMID: 10646083.
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    40. Laouini D, Pardigon N, Kourilsky P. Report on the International Symposium on Vaccinology, November 18-20, Paris, France, organized by the Académie des Sciences and the Marcel Mérieux Foundation. Microbes Infect. 1999 Apr; 1(5):361-5. PMID: 10847773.
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    41. Louzir H, Belal-Kacemi L, Sassi A, Laouini D, Ben Ismail R, Dellagi K. Natural autoantibodies, IgG antibodies to tetanus toxoid and CD5+ B cells in patients with Mediterranean visceral leishmaniasis. The Leishmania Study Group. Clin Exp Immunol. 1994 Mar; 95(3):479-84. PMID: 7511080.
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    42. Louzir H, Triki H, Bennani S, Edelman L, Laouini D, Ben Ismail R, Joab I, Dellagi K. Risk factors for visceral leishmaniasis: role of Epstein-Barr virus infection. Arch Inst Pasteur Tunis. 1993 Jul-Oct; 70(3-4):357-62. PMID: 7802490.
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    43. Tebourski F, Laouini D, Ben Ismaïl R, Dellagi K. Antibodies to Leishmania (L) glycolipids and gangliosides in sera of patients with visceral or with zoonotic L. major leishmaniasis. Arch Inst Pasteur Tunis. 1993 Jul-Oct; 70(3-4):395-6. PMID: 7802494.
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