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Dr Fernanda Ludolf

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    RESEARCH INTERESTS AND GOALS

    Molecular Biology, Proteomics, Genomics, Biomarkers discovery, Vaccine, Diagnostics, Drugs, Signaling pathways, Nanobiotecnology; focused on Infectious Diseases as Schistosomiasis, Leishmaniasis, Chagas disease, Dengue.


    PROFESSIONAL AND RESEARCH EXPERIENCE


    2016 (01/2017-actual) Postdoc (PNPD/CAPES)
    Immunoproteomics applied for the identification of new biomarkers for the diagnosis of visceral leishmaniasis and its association with the human immunodeficiency virus. Post-Graduation Program in Health Sciences: Infectious Diseases and Tropical Medicine. Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BRASIL. Supervised by Dr. Eduardo Antônio Ferraz Coelho.

    2015 (11/2015-12/2016) Junior Postdoc (PDJ/CNPq)
    Development of a polymeric nanoparticles system containing chitosan and chondroitin in order to improve the leishmaniasis treatment. Post-Graduation Program in Health Sciences: Infectious Diseases and Tropical Medicine. Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BRASIL. Supervised by Dr. Eduardo Antônio Ferraz Coelho.

    2014 (06/2014-08/2015) Junior Postdoc (PDJ/CNpQ-INCT)
    INCT for Viral Hemorrhagic Fevers: Cross-kinetic study of the cytokines and chemokines profile of patients with classical dengue. Instituto Evandro Chagas, Belém, Pará, BRAZIL Supervised by Dr. Pedro Fernando da Costa Vasconcelos. Conducted at the CPqRR and co-supervised by Dr. Olindo Assis Martins Filho.

    2012 (07/2012-05/2014) ) Junior Postdoc (PDJ/CNpQ)
    Modeling Drug Induced Resistance in Schistosoma mansoni Endemic Areas. Centro de Pesquisas Rene Rachou, Belo Horizonte, Minas Gerais, BRAZIL Supervised by Dr. Guilherme Oliveira.

    2011 (4 months) Research Scholar Training on Cell-free expression and protein microarray
    The School of Pharmacy, division of Molecular and Cellular Science, Boots Science Building, supervised by Dr. Franco Falcone, University of Nottingham, UK.

    2008-2012 PhD Research Training
    Laboratory of Cellular and Molecular Parasitology, Centro de Pesquisas René Rachou (CPqRR), supervised by Dr. Guilherme Oliveira and Dr. Rosiane Silva-Pereira. THESIS TITLE: Schistosoma mansoni Vaccine Candidate Screening by Bidimensional Western blot.

    2006-2008 Research Scholar Training
    Biomedicine, Programa de Pos-Graduacao e Pesquisa, Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, BRAZIL. Supervised by: Dr. Guilherme Oliveira.

    2005 (1 year) Research Scholar Training on Mass Spectrometry
    The Center for Tropical and Emerging Global Diseases, supervised by Dr. Rick Tarleton, and Complex Carbohydrate Research Center, supervised by Dr. Ronald Orlando and Dr. James Atwood, University of Georgia, USA. NIH grant number: 1D43TW007012-01

    2003-2005 Master Research Training
    Laboratory of Cellular and Molecular Parasitology, Centro de Pesquisas René Rachou (CPqRR), supervised by Dr. Guilherme Oliveira and Dr. Diana Bahia. THESIS TITLE: Molecular characterization of a new protein tyrosine kinase, SmFes, of Schistosoma mansoni.
    Fellowship: CPqRR-FIOCRUZ; FAPEMIG; CNPq; INSERM/FIOCRUZ

    2000-2002 Undergraduate Training
    Laboratory of Cellular and Molecular Parasitology, Centro de Pesquisas René Rachou (CPqRR), supervised by Dr. Guilherme Oliveira. MONOGRAPH TITLE: Identification, cloning and characterization of SmFes, a tyrosine kinase of Schistosoma mansoni.


    AWARDS

    2016 Bill and Melinda Gates Foundation Global Health Travel Award to attend the Keystone Symposium: S1, Translational Vaccinology for Global Health to be held at the Park Plaza Riverbank London, Bill and Melinda Gates Foundation.

    2013 Subsidy Award: Bill & Melinda Gates Foundation Registration Subsidy Award
    Para atender ao encontro: "Advancing Vaccines in the Genomic Era" - Rio de Janeiro, Brazil.

    2012 Sanofi Pasteur Travel Grants for Awards for Latin American Women Physicians and Scientists to attend the 15th International Congress on Infectious Disease – Bangkok, Thailand.

    2011 ISID/ESCMID (International Society for Infectious Diseases / European Society of Clinical Microbiology and Infectious Diseases ) Fellowship Program to research (Training on: Protein microarray) at Dr. Franco Falconi´s lab in the School of Pharmacy at The University of Nottingham for a total period of 1 month (September 2012) – Nottingham (England).
    (http://www.isid.org/grants/grants_awardees_recent.shtml)
    (http://www.escmid.org/profession_career/awards_grants/isidescmid_joint_fellowships/)

    2011 Boehringer Ingelheim Fonds travel grant to research (Training on: Cell-free expression) at Dr. Franco Falconi´s lab in the School of Pharmacy at The University of Nottingham for a total period of 3 months (May-July 2012) – Nottingham (England).
    (http://www.bifonds.de/fellowships-grants/travel-grants.html)

    2010 National Foundation for Infections Diseases Travel Grants to attend the 13th Annual Conference on Vaccine Research – Washington (USA).

    2008 Bill and Melinda Gates Foundation Global Health Travel Award to attend the Keystone Symposia B4 Pathogenesis and Immune Regulation in Helminth Infections – Lake Tahoe (USA)..

    2000 Student Praiseworthy Award, I semester at the second year of the college, PUC-MG.

    2000 Student Praiseworthy Award, II semester at the third year of the college, PUC-MG.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sousa JKT, Antinarelli LMR, Mendonça DVC, Lage DP, Tavares GSV, Dias DS, Ribeiro PAF, Ludolf F, Coelho VTS, Oliveira-da-Silva JA, Perin L, Oliveira BA, Alvarenga DF, Chávez-Fumagalli MA, Brandão GC, Nobre V, Pereira GR, Coimbra ES, Coelho EAF. A chloroquinoline derivate presents effective in vitro and in vivo antileishmanial activity against Leishmania species that cause tegumentary and visceral leishmaniasis. Parasitol Int. 2019 Dec; 73:101966. PMID: 31362122.
      View in: PubMed
    2. Lage DP, Ludolf F, Silveira PC, Machado AS, Ramos FF, Dias DS, Ribeiro PAF, Costa LE, Vale DL, Tavares GSV, Martins VT, Chávez-Fumagalli MA, Caligiorne RB, Chaves AT, Gonçalves DU, Rocha MOC, Duarte MC, Coelho EAF. Screening diagnostic candidates from Leishmania infantum proteins for human visceral leishmaniasis using an immunoproteomics approach. Parasitology. 2019 09; 146(11):1467-1476. PMID: 31142384.
      View in: PubMed
    3. Soyer TG, Mendonça DVC, Tavares GSV, Lage DP, Dias DS, Ribeiro PAF, Perin L, Ludolf F, Coelho VTS, Ferreira ACG, Neves PHAS, Matos GF, Chávez-Fumagalli MA, Coimbra ES, Pereira GR, Coelho EAF, Antinarelli LMR. Evaluation of the in vitro and in vivo antileishmanial activity of a chloroquinolin derivative against Leishmania species capable of causing tegumentary and visceral leishmaniasis. Exp Parasitol. 2019 Apr; 199:30-37. PMID: 30817917.
      View in: PubMed
    4. Ribeiro PAF, Dias DS, Lage DP, Martins VT, Costa LE, Santos TTO, Ramos FF, Tavares GSV, Mendonça DVC, Ludolf F, Gomes DA, Rodrigues MA, Chávez-Fumagalli MA, Silva ES, Galdino AS, Duarte MC, Roatt BM, Menezes-Souza D, Teixeira AL, Coelho EAF. Immunogenicity and protective efficacy of a new Leishmania hypothetical protein applied as a DNA vaccine or in a recombinant form against Leishmania infantum infection. Mol Immunol. 2019 02; 106:108-118. PMID: 30594673.
      View in: PubMed
    5. Chávez-Fumagalli MA, Lage DP, Tavares GSV, Mendonça DVC, Dias DS, Ribeiro PAF, Ludolf F, Costa LE, Coelho VTS, Coelho EAF. In silico Leishmania proteome mining applied to identify drug target potential to be used to treat against visceral and tegumentary leishmaniasis. J Mol Graph Model. 2019 03; 87:89-97. PMID: 30522092.
      View in: PubMed
    6. Mendonça DVC, Tavares GSV, Lage DP, Soyer TG, Carvalho LM, Dias DS, Ribeiro PAF, Ottoni FM, Antinarelli LMR, Vale DL, Ludolf F, Duarte MC, Coimbra ES, Chávez-Fumagalli MA, Roatt BM, Menezes-Souza D, Barichello JM, Alves RJ, Coelho EAF. In vivo antileishmanial efficacy of a naphthoquinone derivate incorporated into a Pluronic® F127-based polymeric micelle system against Leishmania amazonensis infection. Biomed Pharmacother. 2019 Jan; 109:779-787. PMID: 30551531.
      View in: PubMed
    7. Tavares GSV, Mendonça DVC, Miyazaki CK, Lage DP, Soyer TG, Carvalho LM, Ottoni FM, Dias DS, Ribeiro PAF, Antinarelli LMR, Ludolf F, Duarte MC, Coimbra ES, Chávez-Fumagalli MA, Roatt BM, Menezes-Souza D, Barichello JM, Alves RJ, Coelho EAF. A Pluronic® F127-based polymeric micelle system containing an antileishmanial molecule is immunotherapeutic and effective in the treatment against Leishmania amazonensis infection. Parasitol Int. 2019 Feb; 68(1):63-72. PMID: 30339837.
      View in: PubMed
    8. Ribeiro PAF, Dias DS, Novais MVM, Lage DP, Tavares GSV, Mendonça DVC, Oliveira JS, Chávez-Fumagalli MA, Roatt BM, Duarte MC, Menezes-Souza D, Ludolf F, Tavares CAP, Oliveira MC, Coelho EAF. A Leishmania hypothetical protein-containing liposome-based formulation is highly immunogenic and induces protection against visceral leishmaniasis. Cytokine. 2018 11; 111:131-139. PMID: 30142534.
      View in: PubMed
    9. Dias DS, Ribeiro PAF, Martins VT, Lage DP, Costa LE, Chávez-Fumagalli MA, Ramos FF, Santos TTO, Ludolf F, Oliveira JS, Mendes TAO, Silva ES, Galdino AS, Duarte MC, Roatt BM, Menezes-Souza D, Teixeira AL, Coelho EAF. Vaccination with a CD4+ and CD8+ T-cell epitopes-based recombinant chimeric protein derived from Leishmania infantum proteins confers protective immunity against visceral leishmaniasis. Transl Res. 2018 10; 200:18-34. PMID: 29908151.
      View in: PubMed
    10. Tavares GSV, Mendonça DVC, Lage DP, Granato JDT, Ottoni FM, Ludolf F, Chávez-Fumagalli MA, Duarte MC, Tavares CAP, Alves RJ, Coimbra ES, Coelho EAF. Antileishmanial Activity, Cytotoxicity and Mechanism of Action of Clioquinol Against Leishmania infantum and Leishmania amazonensis Species. Basic Clin Pharmacol Toxicol. 2018 Sep; 123(3):236-246. PMID: 29481714.
      View in: PubMed
    11. Adema CM, Hillier LW, Jones CS, Loker ES, Knight M, Minx P, Oliveira G, Raghavan N, Shedlock A, do Amaral LR, Arican-Goktas HD, Assis JG, Baba EH, Baron OL, Bayne CJ, Bickham-Wright U, Biggar KK, Blouin M, Bonning BC, Botka C, Bridger JM, Buckley KM, Buddenborg SK, Lima Caldeira R, Carleton J, Carvalho OS, Castillo MG, Chalmers IW, Christensens M, Clifton S, Cosseau C, Coustau C, Cripps RM, Cuesta-Astroz Y, Cummins SF, Di Stefano L, Dinguirard N, Duval D, Emrich S, Feschotte C, Feyereisen R, FitzGerald P, Fronick C, Fulton L, Galinier R, Gava SG, Geusz M, Geyer KK, Giraldo-Calderón GI, de Souza Gomes M, Gordy MA, Gourbal B, Grunau C, Hanington PC, Hoffmann KF, Hughes D, Humphries J, Jackson DJ, Jannotti-Passos LK, de Jesus Jeremias W, Jobling S, Kamel B, Kapusta A, Kaur S, Koene JM, Kohn AB, Lawson D, Lawton SP, Liang D, Limpanont Y, Liu S, Lockyer AE, Lovato TAL, Ludolf F, Magrini V, McManus DP, Medina M, Misra M, Mitta G, Mkoji GM, Montague MJ, Montelongo C, Moroz LL, Munoz-Torres MC, Niazi U, Noble LR, Oliveira FS, Pais FS, Papenfuss AT, Peace R, Pena JJ, Pila EA, Quelais T, Raney BJ, Rast JP, Rollinson D, Rosse IC, Rotgans B, Routledge EJ, Ryan KM, Scholte LLS, Storey KB, Swain M, Tennessen JA, Tomlinson C, Trujillo DL, Volpi EV, Walker AJ, Wang T, Wannaporn I, Warren WC, Wu XJ, Yoshino TP, Yusuf M, Zhang SM, Zhao M, Wilson RK. Corrigendum: Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nat Commun. 2017 08 23; 8:16153. PMID: 28832025.
      View in: PubMed
    12. Adema CM, Hillier LW, Jones CS, Loker ES, Knight M, Minx P, Oliveira G, Raghavan N, Shedlock A, do Amaral LR, Arican-Goktas HD, Assis JG, Baba EH, Baron OL, Bayne CJ, Bickham-Wright U, Biggar KK, Blouin M, Bonning BC, Botka C, Bridger JM, Buckley KM, Buddenborg SK, Lima Caldeira R, Carleton J, Carvalho OS, Castillo MG, Chalmers IW, Christensens M, Clifton S, Cosseau C, Coustau C, Cripps RM, Cuesta-Astroz Y, Cummins SF, di Stephano L, Dinguirard N, Duval D, Emrich S, Feschotte C, Feyereisen R, FitzGerald P, Fronick C, Fulton L, Galinier R, Gava SG, Geusz M, Geyer KK, Giraldo-Calderón GI, de Souza Gomes M, Gordy MA, Gourbal B, Grunau C, Hanington PC, Hoffmann KF, Hughes D, Humphries J, Jackson DJ, Jannotti-Passos LK, de Jesus Jeremias W, Jobling S, Kamel B, Kapusta A, Kaur S, Koene JM, Kohn AB, Lawson D, Lawton SP, Liang D, Limpanont Y, Liu S, Lockyer AE, Lovato TL, Ludolf F, Magrini V, McManus DP, Medina M, Misra M, Mitta G, Mkoji GM, Montague MJ, Montelongo C, Moroz LL, Munoz-Torres MC, Niazi U, Noble LR, Oliveira FS, Pais FS, Papenfuss AT, Peace R, Pena JJ, Pila EA, Quelais T, Raney BJ, Rast JP, Rollinson D, Rosse IC, Rotgans B, Routledge EJ, Ryan KM, Scholte LLS, Storey KB, Swain M, Tennessen JA, Tomlinson C, Trujillo DL, Volpi EV, Walker AJ, Wang T, Wannaporn I, Warren WC, Wu XJ, Yoshino TP, Yusuf M, Zhang SM, Zhao M, Wilson RK. Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nat Commun. 2017 05 16; 8:15451. PMID: 28508897.
      View in: PubMed
    13. Duarte MC, Lage DP, Martins VT, Costa LE, Carvalho AMRS, Ludolf F, Santos TTO, Vale DL, Roatt BM, Menezes-Souza D, Fernandes AP, Tavares CAP, Coelho EAF. A vaccine composed of a hypothetical protein and the eukaryotic initiation factor 5a from Leishmania braziliensis cross-protection against Leishmania amazonensis infection. Immunobiology. 2017 02; 222(2):251-260. PMID: 27693018.
      View in: PubMed
    14. Mendonça DV, Lage LM, Lage DP, Chávez-Fumagalli MA, Ludolf F, Roatt BM, Menezes-Souza D, Faraco AA, Castilho RO, Tavares CA, Barichello JM, Duarte MC, Coelho EA. Poloxamer 407 (Pluronic(®) F127)-based polymeric micelles for amphotericin B: In vitro biological activity, toxicity and in vivo therapeutic efficacy against murine tegumentary leishmaniasis. Exp Parasitol. 2016 Oct; 169:34-42. PMID: 27427166.
      View in: PubMed
    15. Duarte MC, Lage DP, Martins VT, Costa LE, Lage LM, Carvalho AM, Ludolf F, Santos TT, Roatt BM, Menezes-Souza D, Fernandes AP, Tavares CA, Coelho EA. A vaccine combining two Leishmania braziliensis proteins offers heterologous protection against Leishmania infantum infection. Mol Immunol. 2016 08; 76:70-9. PMID: 27387277.
      View in: PubMed
    16. de Assis RR, Ludolf F, Nakajima R, Jasinskas A, Oliveira GC, Felgner PL, Gaze ST, Loukas A, LoVerde PT, Bethony JM, Correa-Oliveira R, Calzavara-Silva CE. A next-generation proteome array for Schistosoma mansoni. Int J Parasitol. 2016 06; 46(7):411-5. PMID: 27131510.
      View in: PubMed
    17. Wan D, Ludolf F, Alanine DG, Stretton O, Ali Ali E, Al-Barwary N, Wang X, Doenhoff MJ, Mari A, Fitzsimmons CM, Dunne DW, Nakamura R, Oliveira GC, Alcocer MJ, Falcone FH. Use of humanised rat basophilic leukaemia cell line RS-ATL8 for the assessment of allergenicity of Schistosoma mansoni proteins. PLoS Negl Trop Dis. 2014 Sep; 8(9):e3124. PMID: 25254513.
      View in: PubMed
    18. Ludolf F, Patrocínio PR, Corrêa-Oliveira R, Gazzinelli A, Falcone FH, Teixeira-Ferreira A, Perales J, Oliveira GC, Silva-Pereira RA. Serological screening of the Schistosoma mansoni adult worm proteome. PLoS Negl Trop Dis. 2014 Mar; 8(3):e2745. PMID: 24651847.
      View in: PubMed
    19. Ludolf F, Bahia D, Andrade LF, Cousin A, Capron M, Dissous C, Pierce RJ, Oliveira G. Molecular analysis of SmFes, a tyrosine kinase of Schistosoma mansoni orthologous to the members of the Fes/Fps/Fer family. Biochem Biophys Res Commun. 2007 Aug 17; 360(1):163-72. PMID: 17588535.
      View in: PubMed
    20. Bahia D, Mortara RA, Kusel JR, Andrade LF, Ludolf F, Kuser PR, Avelar L, Trolet J, Dissous C, Pierce RJ, Oliveira G. Schistosoma mansoni: expression of Fes-like tyrosine kinase SmFes in the tegument and terebratorium suggests its involvement in host penetration. Exp Parasitol. 2007 Jul; 116(3):225-32. PMID: 17350619.
      View in: PubMed
    21. Atwood JA, Minning T, Ludolf F, Nuccio A, Weatherly DB, Alvarez-Manilla G, Tarleton R, Orlando R. Glycoproteomics of Trypanosoma cruzi trypomastigotes using subcellular fractionation, lectin affinity, and stable isotope labeling. J Proteome Res. 2006 Dec; 5(12):3376-84. PMID: 17137339.
      View in: PubMed
    22. Bahia D, Andrade LF, Ludolf F, Mortara RA, Oliveira G. Protein tyrosine kinases in Schistosoma mansoni. Mem Inst Oswaldo Cruz. 2006 Sep; 101 Suppl 1:137-43. PMID: 17308761.
      View in: PubMed
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