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Professor Emeritus Lawrence Fleckenstein

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Thomsen EK, Sanuku N, Baea M, Satofan S, Maki E, Lombore B, Schmidt MS, Siba PM, Weil GJ, Kazura JW, Fleckenstein LL, King CL. Efficacy, Safety, and Pharmacokinetics of Coadministered Diethylcarbamazine, Albendazole, and Ivermectin for Treatment of Bancroftian Filariasis. Clin Infect Dis. 2016 Feb 01; 62(3):334-341. PMID: 26486704.
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    2. Bogoch II, Khan K, Abrams H, Nott C, Leung E, Fleckenstein L, Keystone JS. Failure of ivermectin per rectum to achieve clinically meaningful serum levels in two cases of Strongyloides hyperinfection. Am J Trop Med Hyg. 2015 Jul; 93(1):94-6. PMID: 25918215.
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    3. Ouédraogo AL, Bastiaens GJ, Tiono AB, Guelbéogo WM, Kobylinski KC, Ouédraogo A, Barry A, Bougouma EC, Nebie I, Ouattara MS, Lanke KH, Fleckenstein L, Sauerwein RW, Slater HC, Churcher TS, Sirima SB, Drakeley C, Bousema T. Efficacy and safety of the mosquitocidal drug ivermectin to prevent malaria transmission after treatment: a double-blind, randomized, clinical trial. Clin Infect Dis. 2015 Feb 01; 60(3):357-65. PMID: 25414262.
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    4. Morris CA, Pokorny R, Lopez-Lazaro L, Miller RM, Arbe-Barnes S, Duparc S, Borghini-Fuhrer I, Shin JS, Fleckenstein L. Pharmacokinetic interaction between pyronaridine-artesunate and metoprolol. Antimicrob Agents Chemother. 2014 Oct; 58(10):5900-8. PMID: 25070091.
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    5. Schmidt MS, King CL, Thomsen EK, Siba PM, Sanuku N, Fleckenstein L. Liquid chromatography-mass spectrometry analysis of diethylcarbamazine in human plasma for clinical pharmacokinetic studies. J Pharm Biomed Anal. 2014 Sep; 98:307-10. PMID: 24975211.
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    6. Morris CA, Dueker SR, Lohstroh PN, Wang LQ, Fang XP, Jung D, Lopez-Lazaro L, Baker M, Duparc S, Borghini-Fuhrer I, Pokorny R, Shin JS, Fleckenstein L. Mass balance and metabolism of the antimalarial pyronaridine in healthy volunteers. Eur J Drug Metab Pharmacokinet. 2015 Mar; 40(1):75-86. PMID: 24590312.
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    7. Morris CA, Tan B, Duparc S, Borghini-Fuhrer I, Jung D, Shin CS, Fleckenstein L. Effects of body size and gender on the population pharmacokinetics of artesunate and its active metabolite dihydroartemisinin in pediatric malaria patients. Antimicrob Agents Chemother. 2013 Dec; 57(12):5889-900. PMID: 24041884.
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    8. Rutteman GR, Erich SA, Mol JA, Spee B, Grinwis GC, Fleckenstein L, London CA, Efferth T. Safety and efficacy field study of artesunate for dogs with non-resectable tumours. Anticancer Res. 2013 May; 33(5):1819-27. PMID: 23645726.
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    9. Duparc S, Borghini-Fuhrer I, Craft CJ, Arbe-Barnes S, Miller RM, Shin CS, Fleckenstein L. Safety and efficacy of pyronaridine-artesunate in uncomplicated acute malaria: an integrated analysis of individual patient data from six randomized clinical trials. Malar J. 2013 Feb 21; 12:70. PMID: 23433102.
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    10. Kayentao K, Doumbo OK, Pénali LK, Offianan AT, Bhatt KM, Kimani J, Tshefu AK, Kokolomami JH, Ramharter M, de Salazar PM, Tiono AB, Ouédraogo A, Bustos MD, Quicho F, Borghini-Fuhrer I, Duparc S, Shin CS, Fleckenstein L. Pyronaridine-artesunate granules versus artemether-lumefantrine crushed tablets in children with Plasmodium falciparum malaria: a randomized controlled trial. Malar J. 2012 Oct 31; 11:364. PMID: 23113947.
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    11. Rueangweerayut R, Phyo AP, Uthaisin C, Poravuth Y, Binh TQ, Tinto H, Pénali LK, Valecha N, Tien NT, Abdulla S, Borghini-Fuhrer I, Duparc S, Shin CS, Fleckenstein L. Pyronaridine-artesunate versus mefloquine plus artesunate for malaria. N Engl J Med. 2012 Apr 05; 366(14):1298-309. PMID: 22475593.
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    12. Morris CA, Lopez-Lazaro L, Jung D, Methaneethorn J, Duparc S, Borghini-Fuhrer I, Pokorny R, Shin CS, Fleckenstein L. Drug-drug interaction analysis of pyronaridine/artesunate and ritonavir in healthy volunteers. Am J Trop Med Hyg. 2012 Mar; 86(3):489-495. PMID: 22403324.
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    13. Korth-Bradley JM, Parks V, Chalon S, Gourley I, Matschke K, Cailleux K, Fitoussi S, Fleckenstein L. The effect of a high-fat breakfast on the pharmacokinetics of moxidectin in healthy male subjects: a randomized phase I trial. Am J Trop Med Hyg. 2012 Jan; 86(1):122-125. PMID: 22232462.
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    14. Morris D, Podolski J, Kirsch A, Wiehle R, Fleckenstein L. Population pharmacokinetics of telapristone (CDB-4124) and its active monodemethylated metabolite CDB-4453, with a mixture model for total clearance. AAPS J. 2011 Dec; 13(4):665-73. PMID: 22028249.
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    15. Morris CA, Duparc S, Borghini-Fuhrer I, Jung D, Shin CS, Fleckenstein L. Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration. Malar J. 2011 Sep 13; 10:263. PMID: 21914160.
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    16. Korth-Bradley JM, Parks V, Chalon S, Gourley I, Matschke K, Gossart S, Bryson P, Fleckenstein L. Excretion of moxidectin into breast milk and pharmacokinetics in healthy lactating women. Antimicrob Agents Chemother. 2011 Nov; 55(11):5200-4. PMID: 21896908.
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    17. Morris CA, Onyamboko MA, Capparelli E, Koch MA, Atibu J, Lokomba V, Douoguih M, Hemingway-Foday J, Wesche D, Ryder RW, Bose C, Wright L, Tshefu AK, Meshnick S, Fleckenstein L. Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria. Malar J. 2011 May 08; 10:114. PMID: 21548983.
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    18. Onyamboko MA, Meshnick SR, Fleckenstein L, Koch MA, Atibu J, Lokomba V, Douoguih M, Hemingway-Foday J, Wesche D, Ryder RW, Bose C, Wright LL, Tshefu AK, Capparelli EV. Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC. Malar J. 2011 Feb 28; 10:49. PMID: 21352601.
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    19. Poravuth Y, Socheat D, Rueangweerayut R, Uthaisin C, Pyae Phyo A, Valecha N, Rao BH, Tjitra E, Purnama A, Borghini-Fuhrer I, Duparc S, Shin CS, Fleckenstein L. Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodium vivax malaria: a randomized, double-blind, non-inferiority trial. PLoS One. 2011 Jan 18; 6(1):e14501. PMID: 21267072.
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    20. Fusco DN, Downs JA, Satlin MJ, Pahuja M, Ramos L, Barie PS, Fleckenstein L, Murray HW. Non-oral treatment with ivermectin for disseminated strongyloidiasis. Am J Trop Med Hyg. 2010 Oct; 83(4):879-83. PMID: 20889884.
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    21. Tshefu AK, Gaye O, Kayentao K, Thompson R, Bhatt KM, Sesay SS, Bustos DG, Tjitra E, Bedu-Addo G, Borghini-Fuhrer I, Duparc S, Shin CS, Fleckenstein L. Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial. Lancet. 2010 Apr 24; 375(9724):1457-67. PMID: 20417857.
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    22. Tan B, Naik H, Jang IJ, Yu KS, Kirsch LE, Shin CS, Craft JC, Fleckenstein L. Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects. Malar J. 2009 Dec 18; 8:304. PMID: 20021657.
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    23. Rose CE, Paciullo CA, Kelly DR, Dougherty MJ, Fleckenstein LL. Fatal Outcome of Disseminated Strongyloidiasis despite Detectable Plasma and Cerebrospinal Levels of Orally Administered Ivermectin. J Parasitol Res. 2009; 2009. PMID: 20798874.
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    24. Leung V, Al-Rawahi GN, Grant J, Fleckenstein L, Bowie W. Case report: failure of subcutaneous ivermectin in treating Strongyloides hyperinfection. Am J Trop Med Hyg. 2008 Dec; 79(6):853-5. PMID: 19052292.
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    25. Ramharter M, Kurth F, Schreier AC, Nemeth J, Glasenapp Iv, Bélard S, Schlie M, Kammer J, Koumba PK, Cisse B, Mordmüller B, Lell B, Issifou S, Oeuvray C, Fleckenstein L, Kremsner PG. Fixed-dose pyronaridine-artesunate combination for treatment of uncomplicated falciparum malaria in pediatric patients in Gabon. J Infect Dis. 2008 Sep 15; 198(6):911-9. PMID: 18694333.
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    26. Dec Bronsvoort BM, Makepeace BL, Renz A, Tanya VN, Fleckenstein L, Ekale D, Trees AJ. UMF-078: A modified flubendazole with potent macrofilaricidal activity against Onchocerca ochengi in African cattle. Parasit Vectors. 2008 Jun 20; 1(1):18. PMID: 18570639.
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    27. Al-Azzam SI, Fleckenstein L, Cheng KJ, Dzimianski MT, McCall JW. Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs. Biopharm Drug Dispos. 2007 Nov; 28(8):431-8. PMID: 17847063.
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    28. Naik H, Imming P, Schmidt MS, Murry DJ, Fleckenstein L. Development and validation of a liquid chromatography-mass spectrometry assay for the determination of pyronaridine in human blood for application to clinical pharmacokinetic studies. J Pharm Biomed Anal. 2007 Sep 21; 45(1):112-119. PMID: 17681448.
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    29. Naik H, Wei SY, Schmidt MS, Murry DJ, Fleckenstein L. Development and validation of a liquid chromatography-mass spectrometry assay for the determination of pyronaridine in human urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 15; 853(1-2):80-7. PMID: 17409032.
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    30. Turner SA, Maclean JD, Fleckenstein L, Greenaway C. Parenteral administration of ivermectin in a patient with disseminated strongyloidiasis. Am J Trop Med Hyg. 2005 Nov; 73(5):911-4. PMID: 16282302.
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    31. Kitzman D, Wei SY, Fleckenstein L. Liquid chromatographic assay of ivermectin in human plasma for application to clinical pharmacokinetic studies. J Pharm Biomed Anal. 2006 Mar 03; 40(4):1013-20. PMID: 16242280.
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    32. Marty FM, Lowry CM, Rodriguez M, Milner DA, Pieciak WS, Sinha A, Fleckenstein L, Baden LR. Treatment of human disseminated strongyloidiasis with a parenteral veterinary formulation of ivermectin. Clin Infect Dis. 2005 Jul 01; 41(1):e5-8. PMID: 15937753.
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    33. Naik H, Murry DJ, Kirsch LE, Fleckenstein L. Development and validation of a high-performance liquid chromatography-mass spectroscopy assay for determination of artesunate and dihydroartemisinin in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 25; 816(1-2):233-42. PMID: 15664355.
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    34. Kshirsagar NA, Gogtay NJ, Garg BS, Deshmukh PR, Rajgor DD, Kadam VS, Kirodian BG, Ingole NS, Mehendale AM, Fleckenstein L, Karbwang J, Lazdins-Helds JK. Safety, tolerability, efficacy and plasma concentrations of diethylcarbamazine and albendazole co-administration in a field study in an area endemic for lymphatic filariasis in India. Trans R Soc Trop Med Hyg. 2004 Apr; 98(4):205-17. PMID: 15049459.
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    35. Cotreau MM, Warren S, Ryan JL, Fleckenstein L, Vanapalli SR, Brown KR, Rock D, Chen CY, Schwertschlag US. The antiparasitic moxidectin: safety, tolerability, and pharmacokinetics in humans. J Clin Pharmacol. 2003 Oct; 43(10):1108-15. PMID: 14517193.
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    36. Kitzman D, Cheng KJ, Fleckenstein L. HPLC assay for albendazole and metabolites in human plasma for clinical pharmacokinetic studies. J Pharm Biomed Anal. 2002 Oct 15; 30(3):801-13. PMID: 12367706.
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    37. Vanapalli SR, Hung YP, Fleckenstein L, Dzimianski MT, McCall JW. Pharmacokinetics and dose proportionality of oral moxidectin in beagle dogs. Biopharm Drug Dispos. 2002 Oct; 23(7):263-72. PMID: 12355577.
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    38. Shenoy RK, Suma TK, John A, Arun SR, Kumaraswami V, Fleckenstein LL, Na-Bangchang K. The pharmacokinetics, safety and tolerability of the co-administration of diethylcarbamazine and albendazole. Ann Trop Med Parasitol. 2002 Sep; 96(6):603-14. PMID: 12396323.
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    39. Chen YC, Hung YP, Fleckenstein L. Liquid chromatographic assay of moxidectin in human plasma for application to pharmacokinetic studies. J Pharm Biomed Anal. 2002 Jul 31; 29(5):917-26. PMID: 12093526.
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    40. Miller JR, Fleckenstein L. Gas chromatographic assay of diethylcarbamazine in human plasma for application to clinical pharmacokinetic studies. J Pharm Biomed Anal. 2001 Nov; 26(4):665-74. PMID: 11516918.
      View in: PubMed
    41. Chen YC, Fleckenstein L. Improved assay method for the determination of pyronaridine in plasma and whole blood by high-performance liquid chromatography for application to clinical pharmacokinetic studies. J Chromatogr B Biomed Sci Appl. 2001 Mar 05; 752(1):39-46. PMID: 11254195.
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    42. Theplertboon R, Fleckenstein L, Dzimianski MT, McCall JW. Pharmacokinetics of UMF-078, a candidate antifilarial drug, in infected dogs. Am J Trop Med Hyg. 2000 Jan; 62(1):86-91. PMID: 10761730.
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    43. Min DI, Ku YM, Vichiendilokkul A, Fleckenstein LL. A urine metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers. Pharmacotherapy. 1999 Jun; 19(6):753-9. PMID: 10391422.
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    44. Chijioke CP, Umeh RE, Mbah AU, Nwonu P, Fleckenstein LL, Okonkwo PO. Clinical pharmacokinetics of suramin in patients with onchocerciasis. Eur J Clin Pharmacol. 1998 May; 54(3):249-51. PMID: 9681668.
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    45. Li QG, Peggins JO, Fleckenstein LL, Masonic K, Heiffer MH, Brewer TG. The pharmacokinetics and bioavailability of dihydroartemisinin, arteether, artemether, artesunic acid and artelinic acid in rats. J Pharm Pharmacol. 1998 Feb; 50(2):173-82. PMID: 9530985.
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    46. Lee S, Casteel DA, Fleckenstein L. Specific gas chromatographic analysis of diethylcarbamazine in human plasma using solid-phase extraction. J Chromatogr B Biomed Sci Appl. 1997 Dec 19; 704(1-2):181-5. PMID: 9518148.
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    47. Ohrt C, Watt G, Teja-Isavadharm P, Keeratithakul D, Loesuttiviboon L, Webster HK, Schuster B, Fleckenstein L. Pharmacokinetics of an extended-dose halofantrine regimen in patients with malaria and in healthy volunteers. Clin Pharmacol Ther. 1995 May; 57(5):525-32. PMID: 7768075.
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    48. Shmuklarsky MJ, Boudreau EF, Pang LW, Smith JI, Schneider I, Fleckenstein L, Abdelrahim MM, Canfield CJ, Schuster B. Failure of doxycycline as a causal prophylactic agent against Plasmodium falciparum malaria in healthy nonimmune volunteers. Ann Intern Med. 1994 Feb 15; 120(4):294-9. PMID: 8291822.
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    49. Watt G, Loesuttiviboon L, Jongsakul K, Shanks GD, Ohrt CK, Karnasuta C, Schuster B, Fleckenstein L. Efficacy and tolerance of extended-dose halofantrine for drug-resistant falciparum malaria in Thailand. Am J Trop Med Hyg. 1994 Feb; 50(2):187-92. PMID: 8116811.
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    50. Berman JD, Fleckenstein L. Pharmacokinetic justification of antiprotozoal therapy. A US perspective. Clin Pharmacokinet. 1991 Dec; 21(6):479-93. PMID: 1782741.
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    51. Brueckner RP, Fleckenstein L. Simultaneous modeling of the pharmacokinetics and methemoglobin pharmacodynamics of an 8-aminoquinoline candidate antimalarial (WR 238605). Pharm Res. 1991 Dec; 8(12):1505-10. PMID: 1808614.
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    52. Klayman DL, Ager AL, Fleckenstein L, Lin AJ. Transdermal artelinic acid: an effective treatment for Plasmodium berghei-infected mice. Am J Trop Med Hyg. 1991 Nov; 45(5):602-7. PMID: 1951870.
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    53. Coleman MD, Timony G, Fleckenstein L. The disposition of quinine in the rat isolated perfused liver: effect of dose size. J Pharm Pharmacol. 1990 Jan; 42(1):26-9. PMID: 1969945.
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    54. Coleman MD, Fleckenstein L, Heiffer MH. Primaquine disposition in the isolated perfused rat liver: effect of mefloquine induced bile flow reduction. Biopharm Drug Dispos. 1989 Mar-Apr; 10(2):153-64. PMID: 2784984.
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    55. Coleman MD, Fleckenstein L, Geary RS, Brewer TG, Timony GA, Mangold DJ. The disposition of ethiofos (WR-2721) in the isolated perfused rat liver. Radiat Res. 1989 Feb; 117(2):334-41. PMID: 2537989.
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    56. Gawienowski M, Benet LZ, Fleckenstein L, Lin ET. Ion-paired liquid chromatographic method for the analysis of blood and plasma for the antimalarial drug halofantrine and its putative mono-debutylated metabolite. J Chromatogr. 1988 Sep 09; 430(2):412-9. PMID: 3235515.
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    57. Coleman MD, Fleckenstein L, Shipley LA, Heiffer MH. Disposition of the antimalarial, mefloquine, in the isolated perfused rat liver. Biochem Pharmacol. 1988 Jan 15; 37(2):235-9. PMID: 3257698.
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    58. Fleckenstein L, Swynnerton NF, Ludden TM, Mangold DJ. Bioavailability and newer methods of delivery of phosphorothioate radioprotectors. Pharmacol Ther. 1988; 39(1-3):203-12. PMID: 2849124.
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    59. Chulay JD, Fleckenstein L, Smith DH. Pharmacokinetics of antimony during treatment of visceral leishmaniasis with sodium stibogluconate or meglumine antimoniate. Trans R Soc Trop Med Hyg. 1988; 82(1):69-72. PMID: 2845611.
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    60. Aderounmu AF, Fleckenstein L. Pharmacokinetics of chloroquine diphosphate in the dog. J Pharmacol Exp Ther. 1983 Sep; 226(3):633-9. PMID: 6887003.
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    61. Fleckenstein L, Kroening B, Weintraub M. Assessment of the biologic availability of digoxin in man. Clin Pharmacol Ther. 1974 Sep; 16(3):435-43. PMID: 4606249.
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