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Professor Louis Maes

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Viira B, Gendron T, Lanfranchi DA, Cojean S, Horvath D, Marcou G, Varnek A, Maes L, Maran U, Loiseau PM, Davioud-Charvet E. In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids. Molecules. 2016 Jun 29; 21(7). PMID: 27367660.
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    2. Mowbray CE, Braillard S, Speed W, Glossop PA, Whitlock GA, Gibson KR, Mills JE, Brown AD, Gardner JM, Cao Y, Hua W, Morgans GL, Feijens PB, Matheeussen A, Maes LJ. Novel Amino-pyrazole Ureas with Potent In Vitro and In Vivo Antileishmanial Activity. J Med Chem. 2015 Dec 24; 58(24):9615-24. PMID: 26571076.
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    3. Cuesta-Rubio O, Oubada A, Bello A, Maes L, Cos P, Monzote L. Antimicrobial Assessment of Resins from Calophyllum Antillanum and Calophyllum Inophyllum. Phytother Res. 2015 Dec; 29(12):1991-4. PMID: 26514875.
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    4. Hendrickx S, Leemans A, Mondelaers A, Rijal S, Khanal B, Dujardin JC, Delputte P, Cos P, Maes L. Comparative Fitness of a Parent Leishmania donovani Clinical Isolate and Its Experimentally Derived Paromomycin-Resistant Strain. PLoS One. 2015; 10(10):e0140139. PMID: 26469696.
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    5. Kerstens M, Boulet G, Van Kerckhoven M, Clais S, Lanckacker E, Delputte P, Maes L, Cos P. A flow cytometric approach to quantify biofilms. Folia Microbiol (Praha). 2015 Jul; 60(4):335-42. PMID: 25948317.
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    6. Chofor R, Sooriyaarachchi S, Risseeuw MD, Bergfors T, Pouyez J, Johny C, Haymond A, Everaert A, Dowd CS, Maes L, Coenye T, Alex A, Couch RD, Jones TA, Wouters J, Mowbray SL, Van Calenbergh S. Synthesis and bioactivity of ß-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase. J Med Chem. 2015 Apr 09; 58(7):2988-3001. PMID: 25781377.
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    7. Sahar Traoré M, Baldé MA, Camara A, Baldé ES, Diané S, Diallo MS, Keita A, Cos P, Maes L, Pieters L, Mamadou Baldé A. The malaria co-infection challenge: An investigation into the antimicrobial activity of selected Guinean medicinal plants. J Ethnopharmacol. 2015 Nov 04; 174:576-81. PMID: 25773488.
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    8. Sleven R, Lanckacker E, Boulet G, Delputte P, Maes L, Cos P. Development of a novel in vitro onychomycosis model for the evaluation of topical antifungal activity. J Microbiol Methods. 2015 May; 112:73-5. PMID: 25772040.
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    9. Kaiser M, Maes L, Tadoori LP, Spangenberg T, Ioset JR. Repurposing of the Open Access Malaria Box for Kinetoplastid Diseases Identifies Novel Active Scaffolds against Trypanosomatids. J Biomol Screen. 2015 Jun; 20(5):634-45. PMID: 25690568.
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    10. Brücher K, Gräwert T, Konzuch S, Held J, Lienau C, Behrendt C, Illarionov B, Maes L, Bacher A, Wittlin S, Mordmüller B, Fischer M, Kurz T. Prodrugs of reverse fosmidomycin analogues. J Med Chem. 2015 Feb 26; 58(4):2025-35. PMID: 25633870.
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    11. Bardiot D, Thevissen K, De Brucker K, Peeters A, Cos P, Taborda CP, McNaughton M, Maes L, Chaltin P, Cammue BP, Marchand A. 2-(2-oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents. J Med Chem. 2015 Feb 12; 58(3):1502-12. PMID: 25585716.
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    12. Paulussen C, Boulet G, Bosschaerts T, Cos P, Fortin A, Maes L. Efficacy of oleylphosphocholine (OlPC) in vitro and in a mouse model of invasive aspergillosis. Mycoses. 2015 Mar; 58(3):127-32. PMID: 25590577.
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    13. Traore MS, Diane S, Diallo MS, Balde ES, Balde MA, Camara A, Diallo A, Keita A, Cos P, Maes L, Pieters L, Balde AM. In vitro antiprotozoal and cytotoxic activity of ethnopharmacologically selected guinean plants. Planta Med. 2014 Oct; 80(15):1340-4. PMID: 25180493.
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    14. Venkatraj M, Ariën KK, Heeres J, Joossens J, Dirié B, Lyssens S, Michiels J, Cos P, Lewi PJ, Vanham G, Maes L, Van der Veken P, Augustyns K. From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds. Bioorg Med Chem. 2014 Oct 01; 22(19):5241-8. PMID: 25199582.
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    15. Kerstens M, Boulet G, Tritsmans C, Horemans T, Hellings M, Delputte P, Maes L, Cos P. Flow cytometric enumeration of bacteria using TO-PRO®-3 iodide as a single-stain viability dye. J Lab Autom. 2014 Dec; 19(6):555-61. PMID: 25124156.
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    16. Paulussen C, Boulet GA, Cos P, Delputte P, Maes LJ. Animal models of invasive aspergillosis for drug discovery. Drug Discov Today. 2014 Sep; 19(9):1380-6. PMID: 24931219.
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    17. Montrieux E, Perera WH, García M, Maes L, Cos P, Monzote L. In vitro and in vivo activity of major constituents from Pluchea carolinensis against Leishmania amazonensis. Parasitol Res. 2014 Aug; 113(8):2925-32. PMID: 24906989.
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    18. Mothana RA, Al-Musayeib NM, Al-Ajmi MF, Cos P, Maes L. Evaluation of the in vitro antiplasmodial, antileishmanial, and antitrypanosomal activity of medicinal plants used in saudi and yemeni traditional medicine. Evid Based Complement Alternat Med. 2014; 2014:905639. PMID: 24963330.
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    19. Mothana RA, Al-Said MS, Al-Musayeib NM, El Gamal AA, Al-Massarani SM, Al-Rehaily AJ, Abdulkader M, Maes L. In vitro antiprotozoal activity of abietane diterpenoids isolated from Plectranthus barbatus Andr. Int J Mol Sci. 2014 May 12; 15(5):8360-71. PMID: 24823881.
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    20. Jansen K, Heirbaut L, Verkerk R, Cheng JD, Joossens J, Cos P, Maes L, Lambeir AM, De Meester I, Augustyns K, Van der Veken P. Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP). J Med Chem. 2014 Apr 10; 57(7):3053-74. PMID: 24617858.
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    21. Clais S, Boulet G, Kerstens M, Horemans T, Teughels W, Quirynen M, Lanckacker E, De Meester I, Lambeir AM, Delputte P, Maes L, Cos P. Importance of biofilm formation and dipeptidyl peptidase IV for the pathogenicity of clinical Porphyromonas gingivalis isolates. Pathog Dis. 2014 Apr; 70(3):408-13. PMID: 24532232.
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    22. Paulussen C, de Wit K, Boulet G, Cos P, Meerpoel L, Maes L. Pyrrolo[1,2-a][1,4]benzodiazepines show potent in vitro antifungal activity and significant in vivo efficacy in a Microsporum canis dermatitis model in guinea pigs. J Antimicrob Chemother. 2014 Jun; 69(6):1608-10. PMID: 24535279.
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    23. Cretton S, Bartholomeusz TA, Mehl F, Allenbach Y, Matheeussen A, Cos P, Maes L, Christen P. Synthesis and in vitro evaluation of tropane halogenated-derivatives against malaria, sleeping sickness, Chagas disease and leishmaniasis. Med Chem. 2014; 10(8):753-8. PMID: 24813684.
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    24. Monzote L, García M, Pastor J, Gil L, Scull R, Maes L, Cos P, Gille L. Essential oil from Chenopodium ambrosioides and main components: activity against Leishmania, their mitochondria and other microorganisms. Exp Parasitol. 2014 Jan; 136:20-6. PMID: 24184772.
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    25. Al-Massarani SM, El Gamal AA, Al-Musayeib NM, Mothana RA, Basudan OA, Al-Rehaily AJ, Farag M, Assaf MH, El Tahir KH, Maes L. Phytochemical, antimicrobial and antiprotozoal evaluation of Garcinia mangostana pericarp and a-mangostin, its major xanthone derivative. Molecules. 2013 Sep 02; 18(9):10599-608. PMID: 24002136.
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    26. Al Musayeib NM, Mothana RA, Gamal AA, Al-Massarani SM, Maes L. In vitro antiprotozoal activity of triterpenoid constituents of Kleinia odora growing in Saudi Arabia. Molecules. 2013 Jul 31; 18(8):9207-18. PMID: 23912274.
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    27. Lauinger IL, Vivas L, Perozzo R, Stairiker C, Tarun A, Zloh M, Zhang X, Xu H, Tonge PJ, Franzblau SG, Pham DH, Esguerra CV, Crawford AD, Maes L, Tasdemir D. Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target. J Nat Prod. 2013 Jun 28; 76(6):1064-70. PMID: 23806111.
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    28. Falcão SI, Vale N, Cos P, Gomes P, Freire C, Maes L, Vilas-Boas M. In vitro evaluation of Portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activity. Phytother Res. 2014 Mar; 28(3):437-43. PMID: 23722631.
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    29. Maes L. Intravenous and subcutaneous toxicity and absorption kinetics in mice and dogs of the antileishmanial triterpene saponin PX-6518. Molecules. 2013 Apr 22; 18(4):4803-15. PMID: 23609628.
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    30. Jansen K, Heirbaut L, Cheng JD, Joossens J, Ryabtsova O, Cos P, Maes L, Lambeir AM, De Meester I, Augustyns K, Van der Veken P. Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold. ACS Med Chem Lett. 2013 May 09; 4(5):491-6. PMID: 24900696.
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    31. Kerstens M, Boulet G, Pintelon I, Hellings M, Voeten L, Delputte P, Maes L, Cos P. Quantification of Candida albicans by flow cytometry using TO-PRO(®)-3 iodide as a single-stain viability dye. J Microbiol Methods. 2013 Feb 15; 92(2):189-91. PMID: 23266389.
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    32. Verbrugghen T, Vandurm P, Pouyez J, Maes L, Wouters J, Van Calenbergh S. Alpha-heteroatom derivatized analogues of 3-(acetylhydroxyamino)propyl phosphonic acid (FR900098) as antimalarials. J Med Chem. 2013 Jan 10; 56(1):376-80. PMID: 23215035.
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    33. Kulshrestha A, Bhandari V, Mukhopadhyay R, Ramesh V, Sundar S, Maes L, Dujardin JC, Roy S, Salotra P. Validation of a simple resazurin-based promastigote assay for the routine monitoring of miltefosine susceptibility in clinical isolates of Leishmania donovani. Parasitol Res. 2013 Feb; 112(2):825-8. PMID: 23239091.
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    34. Deprez-Poulain R, Flipo M, Piveteau C, Leroux F, Dassonneville S, Florent I, Maes L, Cos P, Deprez B. Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors. J Med Chem. 2012 Dec 27; 55(24):10909-17. PMID: 23176597.
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    35. Mothana RA, Al-Musayeib NM, Matheeussen A, Cos P, Maes L. Assessment of the in vitro antiprotozoal and cytotoxic potential of 20 selected medicinal plants from the island of Soqotra. Molecules. 2012 Dec 03; 17(12):14349-60. PMID: 23208469.
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    36. Monzote L, Cuesta-Rubio O, Campo Fernandez M, Márquez Hernandez I, Fraga J, Pérez K, Kerstens M, Maes L, Cos P. In vitro antimicrobial assessment of Cuban propolis extracts. Mem Inst Oswaldo Cruz. 2012 Dec; 107(8):978-84. PMID: 23295746.
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    37. Orhan IE, Kartal M, Gülpinar AR, Cos P, Matheeussen A, Maes L, Tasdemir D. Assessment of antimicrobial and antiprotozoal activity of the olive oil macerate samples of Hypericum perforatum and their LC-DAD-MS analyses. Food Chem. 2013 Jun 01; 138(2-3):870-5. PMID: 23411190.
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    38. Orrling KM, Jansen C, Vu XL, Balmer V, Bregy P, Shanmugham A, England P, Bailey D, Cos P, Maes L, Adams E, van den Bogaart E, Chatelain E, Ioset JR, van de Stolpe A, Zorg S, Veerman J, Seebeck T, Sterk GJ, de Esch IJ, Leurs R. Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase B1. J Med Chem. 2012 Oct 25; 55(20):8745-56. PMID: 22963052.
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    39. Al-Musayeib NM, Mothana RA, Al-Massarani S, Matheeussen A, Cos P, Maes L. Study of the in vitro antiplasmodial, antileishmanial and antitrypanosomal activities of medicinal plants from Saudi Arabia. Molecules. 2012 Sep 25; 17(10):11379-90. PMID: 23011279.
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    40. Van Brussel I, Schrijvers DM, Martinet W, Pintelon I, Deschacht M, Schnorbusch K, Maes L, Bosmans JM, Vrints CJ, Adriaensen D, Cos P, Bult H. Transcript and protein analysis reveals better survival skills of monocyte-derived dendritic cells compared to monocytes during oxidative stress. PLoS One. 2012; 7(8):e43357. PMID: 22916248.
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    41. Brücher K, Illarionov B, Held J, Tschan S, Kunfermann A, Pein MK, Bacher A, Gräwert T, Maes L, Mordmüller B, Fischer M, Kurz T. a-Substituted ß-oxa isosteres of fosmidomycin: synthesis and biological evaluation. J Med Chem. 2012 Jul 26; 55(14):6566-75. PMID: 22731758.
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    42. Fortin A, Hendrickx S, Yardley V, Cos P, Jansen H, Maes L. Efficacy and tolerability of oleylphosphocholine (OlPC) in a laboratory model of visceral leishmaniasis. J Antimicrob Chemother. 2012 Nov; 67(11):2707-12. PMID: 22782488.
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    43. Deschacht M, Van Assche T, Hendrickx S, Bult H, Maes L, Cos P. Role of oxidative stress and apoptosis in the cellular response of murine macrophages upon Leishmania infection. Parasitology. 2012 Sep; 139(11):1429-37. PMID: 22776404.
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    44. Vanaerschot M, Decuypere S, Downing T, Imamura H, Stark O, De Doncker S, Roy S, Ostyn B, Maes L, Khanal B, Boelaert M, Schönian G, Berriman M, Chappuis F, Dujardin JC, Sundar S, Rijal S. Genetic markers for SSG resistance in Leishmania donovani and SSG treatment failure in visceral leishmaniasis patients of the Indian subcontinent. J Infect Dis. 2012 Sep 01; 206(5):752-5. PMID: 22753945.
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    45. Brackman G, Risseeuw M, Celen S, Cos P, Maes L, Nelis HJ, Van Calenbergh S, Coenye T. Synthesis and evaluation of the quorum sensing inhibitory effect of substituted triazolyldihydrofuranones. Bioorg Med Chem. 2012 Aug 01; 20(15):4737-43. PMID: 22748377.
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    46. Hendrickx S, Inocêncio da Luz RA, Bhandari V, Kuypers K, Shaw CD, Lonchamp J, Salotra P, Carter K, Sundar S, Rijal S, Dujardin JC, Cos P, Maes L. Experimental induction of paromomycin resistance in antimony-resistant strains of L. donovani: outcome dependent on in vitro selection protocol. PLoS Negl Trop Dis. 2012; 6(5):e1664. PMID: 22666513.
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    47. Abouzid SF, Wahba HM, Elshamy A, Cos P, Maes L, Apers S, Pieters L, Shahat AA. Antimicrobial activity of some Clerodendrum species from Egypt. Nat Prod Res. 2013; 27(11):1032-6. PMID: 22594542.
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    48. Al-Musayeib NM, Mothana RA, Matheeussen A, Cos P, Maes L. In vitro antiplasmodial, antileishmanial and antitrypanosomal activities of selected medicinal plants used in the traditional Arabian Peninsular region. BMC Complement Altern Med. 2012 Apr 20; 12:49. PMID: 22520595.
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    49. Horemans T, Kerstens M, Clais S, Struijs K, van den Abbeele P, Van Assche T, Maes L, Cos P. Evaluation of the anti-adhesive effect of milk fat globule membrane glycoproteins on Helicobacter pylori in the human NCI-N87 cell line and C57BL/6 mouse model. Helicobacter. 2012 Aug; 17(4):312-8. PMID: 22759332.
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    50. Beghyn TB, Charton J, Leroux F, Henninot A, Reboule I, Cos P, Maes L, Deprez B. Drug-to-genome-to-drug, step 2: reversing selectivity in a series of antiplasmodial compounds. J Med Chem. 2012 Feb 09; 55(3):1274-86. PMID: 22204607.
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    51. Nwaka S, Besson D, Ramirez B, Maes L, Matheeussen A, Bickle Q, Mansour NR, Yousif F, Townson S, Gokool S, Cho-Ngwa F, Samje M, Misra-Bhattacharya S, Murthy PK, Fakorede F, Paris JM, Yeates C, Ridley R, Van Voorhis WC, Geary T. Integrated dataset of screening hits against multiple neglected disease pathogens. PLoS Negl Trop Dis. 2011 Dec; 5(12):e1412. PMID: 22247786.
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    52. Behrendt CT, Kunfermann A, Illarionova V, Matheeussen A, Pein MK, Gräwert T, Kaiser J, Bacher A, Eisenreich W, Illarionov B, Fischer M, Maes L, Groll M, Kurz T. Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr). J Med Chem. 2011 Oct 13; 54(19):6796-802. PMID: 21866890.
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    53. Bénéré E, Van Assche T, Cos P, Maes L. Intrinsic susceptibility of Giardia duodenalis assemblage subtypes A(I), A(II), B and E(III) for nitric oxide under axenic culture conditions. Parasitol Res. 2012 Mar; 110(3):1315-9. PMID: 21894509.
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    54. Vanaerschot M, De Doncker S, Rijal S, Maes L, Dujardin JC, Decuypere S. Antimonial resistance in Leishmania donovani is associated with increased in vivo parasite burden. PLoS One. 2011; 6(8):e23120. PMID: 21829701.
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    55. Foubert K, Cuyckens F, Matheeussen A, Vlietinck A, Apers S, Maes L, Pieters L. Antiprotozoal and antiangiogenic saponins from Apodytes dimidiata. Phytochemistry. 2011 Aug; 72(11-12):1414-23. PMID: 21601896.
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    56. Fernández-Calienes A, Pellón R, Docampo M, Fascio M, D'Accorso N, Maes L, Mendiola J, Monzote L, Gille L, Rojas L. Antimalarial activity of new acridinone derivatives. Biomed Pharmacother. 2011 Jun; 65(3):210-4. PMID: 21641752.
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    57. Van Assche T, Deschacht M, da Luz RA, Maes L, Cos P. Leishmania-macrophage interactions: insights into the redox biology. Free Radic Biol Med. 2011 Jul 15; 51(2):337-51. PMID: 21620959.
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    58. Adaui V, Castillo D, Zimic M, Gutierrez A, Decuypere S, Vanaerschot M, De Doncker S, Schnorbusch K, Maes I, Van der Auwera G, Maes L, Llanos-Cuentas A, Arevalo J, Dujardin JC. Comparative gene expression analysis throughout the life cycle of Leishmania braziliensis: diversity of expression profiles among clinical isolates. PLoS Negl Trop Dis. 2011 May 10; 5(5):e1021. PMID: 21572980.
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    59. Thevissen K, Pellens K, De Brucker K, François IE, Chow KK, Meert EM, Meert W, Van Minnebruggen G, Borgers M, Vroome V, Levin J, De Vos D, Maes L, Cos P, Cammue BP. Novel fungicidal benzylsulfanyl-phenylguanidines. Bioorg Med Chem Lett. 2011 Jun 15; 21(12):3686-92. PMID: 21576022.
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    60. Beghyn TB, Charton J, Leroux F, Laconde G, Bourin A, Cos P, Maes L, Deprez B. Drug to genome to drug: discovery of new antiplasmodial compounds. J Med Chem. 2011 May 12; 54(9):3222-40. PMID: 21504142.
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    61. Oduor RO, Ojo KK, Williams GP, Bertelli F, Mills J, Maes L, Pryde DC, Parkinson T, Van Voorhis WC, Holler TP. Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads. PLoS Negl Trop Dis. 2011 Apr 05; 5(4):e1017. PMID: 21483717.
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    62. Horemans T, Deschacht M, Clais S, Van Camp J, de Rijk P, Holvoet J, Van Assche T, Maes L, Cos P. An alternative, sensitive method to detect Helicobacter pylori DNA in feces. Helicobacter. 2011 Apr; 16(2):113-8. PMID: 21435088.
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    63. Brackman G, Cos P, Maes L, Nelis HJ, Coenye T. Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo. Antimicrob Agents Chemother. 2011 Jun; 55(6):2655-61. PMID: 21422204.
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    64. Brackman G, Celen S, Hillaert U, Van Calenbergh S, Cos P, Maes L, Nelis HJ, Coenye T. Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp. PLoS One. 2011 Jan 13; 6(1):e16084. PMID: 21249192.
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    65. Inocêncio da Luz R, Romero GA, Dorval ME, Cruz I, Cañavate C, Dujardin JC, Van Assche T, Cos P, Maes L. Drug susceptibility of Leishmania infantum (syn. Leishmania chagasi) isolates from Brazilian HIV-positive and HIV-negative patients. J Antimicrob Chemother. 2011 Mar; 66(3):677-9. PMID: 21393233.
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    66. Inocêncio da Luz RA, Vermeersch M, Deschacht M, Hendrickx S, Van Assche T, Cos P, Maes L. In vitro and in vivo prophylactic and curative activity of the triterpene saponin PX-6518 against cutaneous Leishmania species. J Antimicrob Chemother. 2011 Feb; 66(2):350-3. PMID: 21131319.
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    67. Tangmouo JG, Ho R, Matheeussen A, Lannang AM, Komguem J, Messi BB, Maes L, Hostettmann K. Antimalarial activity of extract and norbergenin derivatives from the stem bark of Diospyros sanza-minika A. Chevalier (Ebenaceae). Phytother Res. 2010 Nov; 24(11):1676-9. PMID: 21031627.
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    68. Steert K, Berg M, Mottram JC, Westrop GD, Coombs GH, Cos P, Maes L, Joossens J, Van der Veken P, Haemers A, Augustyns K. a-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB. ChemMedChem. 2010 Oct 04; 5(10):1734-48. PMID: 20799311.
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    69. Behrendt CT, Kunfermann A, Illarionova V, Matheeussen A, Gräwert T, Groll M, Rohdich F, Bacher A, Eisenreich W, Fischer M, Maes L, Kurz T. Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin. ChemMedChem. 2010 Oct 04; 5(10):1673-6. PMID: 20718073.
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    70. Abdel-Sattar E, Maes L, Salama MM. In vitro activities of plant extracts from Saudi Arabia against malaria, leishmaniasis, sleeping sickness and Chagas disease. Phytother Res. 2010 Sep; 24(9):1322-8. PMID: 20127723.
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    71. de Wit K, Paulussen C, Matheeussen A, van Rossem K, Cos P, Maes L. In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. Antimicrob Agents Chemother. 2010 Nov; 54(11):4927-9. PMID: 20805398.
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    72. Vanaerschot M, Maes I, Ouakad M, Adaui V, Maes L, De Doncker S, Rijal S, Chappuis F, Dujardin JC, Decuypere S. Linking in vitro and in vivo survival of clinical Leishmania donovani strains. PLoS One. 2010 Aug 17; 5(8):e12211. PMID: 20808916.
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    73. Bénéré E, Geurden T, Robertson L, Van Assche T, Cos P, Maes L. Infectivity of Giardia duodenalis Assemblages A and E for the gerbil and axenisation of duodenal trophozoites. Parasitol Int. 2010 Dec; 59(4):634-7. PMID: 20696269.
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    74. Verbrugghen T, Cos P, Maes L, Van Calenbergh S. Synthesis and evaluation of alpha-halogenated analogues of 3-(acetylhydroxyamino)propylphosphonic acid (FR900098) as antimalarials. J Med Chem. 2010 Jul 22; 53(14):5342-6. PMID: 20568776.
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    75. Deschacht M, Horemans T, Martinet W, Bult H, Maes L, Cos P. Comparative EPR study of different macrophage types stimulated for superoxide and nitric oxide production. Free Radic Res. 2010 Jul; 44(7):763-72. PMID: 20446898.
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    76. Bradacs G, Maes L, Heilmann J. In vitro cytotoxic, antiprotozoal and antimicrobial activities of medicinal plants from Vanuatu. Phytother Res. 2010 Jun; 24(6):800-9. PMID: 20014163.
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    77. Baldé ES, Megalizzi V, Traoré MS, Cos P, Maes L, Decaestecker C, Pieters L, Baldé AM. In vitro antiprotozoal, antimicrobial and antitumor activity of Pavetta crassipes K. Schum leaf extracts. J Ethnopharmacol. 2010 Aug 09; 130(3):529-35. PMID: 20561931.
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    78. Cretton S, Glauser G, Humam M, Jeannerat D, Muñoz O, Maes L, Christen P, Hostettmann K. Isomeric tropane alkaloids from the aerial parts of Schizanthus tricolor. J Nat Prod. 2010 May 28; 73(5):844-7. PMID: 20166702.
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    79. Mesia K, Cimanga RK, Dhooghe L, Cos P, Apers S, Totté J, Tona GL, Pieters L, Vlietinck AJ, Maes L. Antimalarial activity and toxicity evaluation of a quantified Nauclea pobeguinii extract. J Ethnopharmacol. 2010 Aug 19; 131(1):10-6. PMID: 20470876.
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    80. Wenzel NI, Chavain N, Wang Y, Friebolin W, Maes L, Pradines B, Lanzer M, Yardley V, Brun R, Herold-Mende C, Biot C, Tóth K, Davioud-Charvet E. Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA. J Med Chem. 2010 Apr 22; 53(8):3214-26. PMID: 20329733.
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    81. Maregesi SM, Hermans N, Dhooghe L, Cimanga K, Ferreira D, Pannecouque C, Vanden Berghe DA, Cos P, Maes L, Vlietinck AJ, Apers S, Pieters L. Phytochemical and biological investigations of Elaeodendron schlechteranum. J Ethnopharmacol. 2010 Jun 16; 129(3):319-26. PMID: 20371284.
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    82. Berg M, Kohl L, Van der Veken P, Joossens J, Al-Salabi MI, Castagna V, Giannese F, Cos P, Versées W, Steyaert J, Grellier P, Haemers A, Degano M, Maes L, de Koning HP, Augustyns K. Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis. Antimicrob Agents Chemother. 2010 May; 54(5):1900-8. PMID: 20194690.
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    83. Dhooghe L, Maregesi S, Mincheva I, Ferreira D, Marais JP, Lemière F, Matheeussen A, Cos P, Maes L, Vlietinck A, Apers S, Pieters L. Antiplasmodial activity of (I-3,II-3)-biflavonoids and other constituents from Ormocarpum kirkii. Phytochemistry. 2010 May; 71(7):785-91. PMID: 20189612.
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    84. Fotie J, Kaiser M, Delfín DA, Manley J, Reid CS, Paris JM, Wenzler T, Maes L, Mahasenan KV, Li C, Werbovetz KA. Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives. J Med Chem. 2010 Feb 11; 53(3):966-82. PMID: 20047276.
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    85. Berg M, Van der Veken P, Joossens J, Muthusamy V, Breugelmans M, Moss CX, Rudolf J, Cos P, Coombs GH, Maes L, Haemers A, Mottram JC, Augustyns K. Design and evaluation of Trypanosoma brucei metacaspase inhibitors. Bioorg Med Chem Lett. 2010 Mar 15; 20(6):2001-6. PMID: 20167486.
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    86. Simões-Pires CA, Vargas S, Marston A, Ioset JR, Paulo MQ, Matheeussen A, Maes L. Ellagic acid derivatives from Syzygium cumini stem bark: investigation of their antiplasmodial activity. Nat Prod Commun. 2009 Oct; 4(10):1371-6. PMID: 19911574.
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    87. Vermeersch M, Foubert K, da Luz RI, Van Puyvelde L, Pieters L, Cos P, Maes L. Selective antileishmania activity of 13,28-epoxy-oleanane and related triterpene saponins from the plant families Myrsinaceae, Primulaceae, Aceraceae and Icacinaceae. Phytother Res. 2009 Oct; 23(10):1404-10. PMID: 19274770.
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    88. da Luz RI, Vermeersch M, Dujardin JC, Cos P, Maes L. In vitro sensitivity testing of Leishmania clinical field isolates: preconditioning of promastigotes enhances infectivity for macrophage host cells. Antimicrob Agents Chemother. 2009 Dec; 53(12):5197-203. PMID: 19752271.
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    89. Van Baelen G, Hostyn S, Dhooghe L, Tapolcsányi P, Mátyus P, Lemière G, Dommisse R, Kaiser M, Brun R, Cos P, Maes L, Hajós G, Riedl Z, Nagy I, Maes BU, Pieters L. Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues. Bioorg Med Chem. 2009 Oct 15; 17(20):7209-17. PMID: 19781948.
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    90. Nwaka S, Ramirez B, Brun R, Maes L, Douglas F, Ridley R. Advancing drug innovation for neglected diseases-criteria for lead progression. PLoS Negl Trop Dis. 2009 Aug 25; 3(8):e440. PMID: 19707561.
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    91. Vermeersch M, da Luz RI, Toté K, Timmermans JP, Cos P, Maes L. In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differences. Antimicrob Agents Chemother. 2009 Sep; 53(9):3855-9. PMID: 19546361.
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    92. Elfita E, Muharni M, Latief M, Darwati D, Widiyantoro A, Supriyatna S, Bahti HH, Dachriyanus D, Cos P, Maes L, Foubert K, Apers S, Pieters L. Antiplasmodial and other constituents from four Indonesian Garcinia spp. Phytochemistry. 2009 May; 70(7):907-12. PMID: 19481231.
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    93. El Sayed I, Van der Veken P, Steert K, Dhooghe L, Hostyn S, Van Baelen G, Lemière G, Maes BU, Cos P, Maes L, Joossens J, Haemers A, Pieters L, Augustyns K. Synthesis and antiplasmodial activity of aminoalkylamino-substituted neocryptolepine derivatives. J Med Chem. 2009 May 14; 52(9):2979-88. PMID: 19364118.
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    94. Wenzel IN, Wong PE, Maes L, Müller TJ, Krauth-Siegel RL, Barrett MP, Davioud-Charvet E. Unsaturated Mannich bases active against multidrug-resistant Trypanosoma brucei brucei strains. ChemMedChem. 2009 Mar; 4(3):339-51. PMID: 19219843.
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    95. Foubert K, Vermeersch M, Theunis M, Apers S, Cos P, Claeys M, Van Puyvelde L, Pieters L, Maes L. LC-MS analysis of 13,28-epoxy-oleanane saponins in Maesa spp. extracts with antileishmanial activity. Phytochem Anal. 2009 Mar-Apr; 20(2):159-67. PMID: 19219852.
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    96. Vik A, Proszenyák A, Vermeersch M, Cos P, Maes L, Gundersen LL. Screening of agelasine D and analogs for inhibitory activity against pathogenic protozoa; identification of hits for visceral leishmaniasis and Chagas disease. Molecules. 2009 Jan 08; 14(1):279-88. PMID: 19136916.
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    97. Valdés AF, Martínez JM, Lizama RS, Vermeersch M, Cos P, Maes L. In vitro anti-microbial activity of the Cuban medicinal plants Simarouba glauca DC, Melaleuca leucadendron L and Artemisia absinthium L. Mem Inst Oswaldo Cruz. 2008 Sep; 103(6):615-8. PMID: 18949336.
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    98. Cos P, Maes L, Vlietinck A, Pieters L. Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection - an update (1998 - 2007). Planta Med. 2008 Sep; 74(11):1323-37. PMID: 18671200.
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    99. Delarue-Cochin S, Grellier P, Maes L, Mouray E, Sergheraert C, Melnyk P. Synthesis and antimalarial activity of carbamate and amide derivatives of 4-anilinoquinoline. Eur J Med Chem. 2008 Oct; 43(10):2045-55. PMID: 18226428.
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    100. Bénéré E, da Luz RA, Vermeersch M, Cos P, Maes L. A new quantitative in vitro microculture method for Giardia duodenalis trophozoites. J Microbiol Methods. 2007 Nov; 71(2):101-6. PMID: 17888535.
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    101. Delarue-Cochin S, Paunescu E, Maes L, Mouray E, Sergheraert C, Grellier P, Melnyk P. Synthesis and antimalarial activity of new analogues of amodiaquine. Eur J Med Chem. 2008 Feb; 43(2):252-60. PMID: 17485145.
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    102. Hermans N, Cos P, De Meyer GR, Maes L, Pieters L, Vanden Berghe D, Vlietinck AJ, De Bruyne T. Study of potential systemic oxidative stress animal models for the evaluation of antioxidant activity: status of lipid peroxidation and fat-soluble antioxidants. J Pharm Pharmacol. 2007 Jan; 59(1):131-6. PMID: 17227630.
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    103. Kapingu MC, Mbwambo ZH, Moshi MJ, Magadula JJ, Cos P, Berghe DV, Maes L, Theunis M, Apers S, Pieters L, Vlietinck A. A novel isoflavonoid from Millettia puguensis. Planta Med. 2006 Nov; 72(14):1341-3. PMID: 17054049.
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    104. Cos P, Vlietinck AJ, Berghe DV, Maes L. Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'. J Ethnopharmacol. 2006 Jul 19; 106(3):290-302. PMID: 16698208.
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    105. Mbwambo ZH, Kapingu MC, Moshi MJ, Machumi F, Apers S, Cos P, Ferreira D, Marais JP, Vanden Berghe D, Maes L, Vlietinck A, Pieters L. Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei. J Nat Prod. 2006 Mar; 69(3):369-72. PMID: 16562837.
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    106. Surleraux DL, de Kock HA, Verschueren WG, Pille GM, Maes LJ, Peeters A, Vendeville S, De Meyer S, Azijn H, Pauwels R, de Bethune MP, King NM, Prabu-Jeyabalan M, Schiffer CA, Wigerinck PB. Design of HIV-1 protease inhibitors active on multidrug-resistant virus. J Med Chem. 2005 Mar 24; 48(6):1965-73. PMID: 15771440.
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    107. Germonprez N, Maes L, Van Puyvelde L, Van Tri M, Tuan DA, De Kimpe N. In vitro and in vivo anti-leishmanial activity of triterpenoid saponins isolated from Maesa balansae and some chemical derivatives. J Med Chem. 2005 Jan 13; 48(1):32-7. PMID: 15633999.
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    108. Van Miert S, Jonckers T, Cimanga K, Maes L, Maes B, Lemière G, Dommisse R, Vlietinck A, Pieters L. In vitro inhibition of beta-haematin formation, DNA interactions, antiplasmodial activity, and cytotoxicity of synthetic neocryptolepine derivatives. Exp Parasitol. 2004 Nov-Dec; 108(3-4):163-8. PMID: 15582513.
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    109. Maes L, Germonprez N, Quirijnen L, Van Puyvelde L, Cos P, Vanden Berghe D. Comparative activities of the triterpene saponin maesabalide III and liposomal amphotericin B (AmBisome) against Leishmania donovani in hamsters. Antimicrob Agents Chemother. 2004 Jun; 48(6):2056-60. PMID: 15155199.
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    110. Cos P, Maes L, Vanden Berghe D, Hermans N, Pieters L, Vlietinck A. Plant substances as anti-HIV agents selected according to their putative mechanism of action. J Nat Prod. 2004 Feb; 67(2):284-93. PMID: 14987070.
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    111. Maes L, Vanden Berghe D, Germonprez N, Quirijnen L, Cos P, De Kimpe N, Van Puyvelde L. In vitro and in vivo activities of a triterpenoid saponin extract (PX-6518) from the plant Maesa balansae against visceral leishmania species. Antimicrob Agents Chemother. 2004 Jan; 48(1):130-6. PMID: 14693530.
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    112. Leonard S, Capote R, Germonprez N, Van Puyvelde L, De Kimpe N, Vermeersch H, Rosier J, Maes L, Roets E, Hoogmartens J. Liquid chromatographic method for analysis of saponins in Maesa balansae extract active against leishmaniasis. J Chromatogr A. 2003 Sep 12; 1012(1):39-46. PMID: 14509340.
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    113. He W, Van Puyvelde L, Maes L, Bosselaers J, De Kimpe N. Antitrichomonas in vitro activity of Cussonia holstii Engl. Nat Prod Res. 2003 Apr; 17(2):127-33. PMID: 12713125.
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    114. Ryckebusch A, Deprez-Poulain R, Maes L, Debreu-Fontaine MA, Mouray E, Grellier P, Sergheraert C. Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives. J Med Chem. 2003 Feb 13; 46(4):542-57. PMID: 12570376.
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    115. Millet R, Maes L, Landry V, Sergheraert C, Davioud-Charvet E. Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides. Bioorg Med Chem Lett. 2002 Dec 16; 12(24):3601-4. PMID: 12443785.
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    116. Jonckers TH, van Miert S, Cimanga K, Bailly C, Colson P, De Pauw-Gillet MC, van den Heuvel H, Claeys M, Lemière F, Esmans EL, Rozenski J, Quirijnen L, Maes L, Dommisse R, Lemière GL, Vlietinck A, Pieters L. Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives. J Med Chem. 2002 Aug 01; 45(16):3497-508. PMID: 12139461.
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    117. Kuria KA, Chepkwony H, Govaerts C, Roets E, Busson R, De Witte P, Zupko I, Hoornaert G, Quirynen L, Maes L, Janssens L, Hoogmartens J, Laekeman G. The antiplasmodial activity of isolates from Ajuga remota. J Nat Prod. 2002 May; 65(5):789-93. PMID: 12027771.
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    118. Golisade A, Herforth C, Quirijnen L, Maes L, Link A. Improving an antitrypanosomal lead applying nucleophilic substitution on a safety catch linker. Bioorg Med Chem. 2002 Jan; 10(1):159-65. PMID: 11738617.
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    119. Davioud-Charvet E, Delarue S, Biot C, Schwöbel B, Boehme CC, Müssigbrodt A, Maes L, Sergheraert C, Grellier P, Schirmer RH, Becker K. A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline. J Med Chem. 2001 Nov 22; 44(24):4268-76. PMID: 11708927.
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    120. Delarue S, Girault S, Maes L, Debreu-Fontaine MA, Labaeïd M, Grellier P, Sergheraert C. Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines. J Med Chem. 2001 Aug 16; 44(17):2827-33. PMID: 11495593.
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    121. Delarue S, Girault S, Dali Ali F, Maes L, Grellier P, Sergheraert C. "One-pot" synthesis and antimalarial activity of formamidine derivatives of 4-anilinoquinoline. Chem Pharm Bull (Tokyo). 2001 Aug; 49(8):933-7. PMID: 11515580.
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    122. Girault S, Delarue S, Grellier P, Berecibar A, Maes L, Quirijnen L, Lemiere P, Debreu-Fontaine MA, Sergheraert C. Antimalarial in-vivo activity of bis(9-amino-6-chloro-2-methoxyacridines). J Pharm Pharmacol. 2001 Jul; 53(7):935-8. PMID: 11480542.
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    123. Girault S, Grellier P, Berecibar A, Maes L, Lemière P, Mouray E, Davioud-Charvet E, Sergheraert C. Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers. J Med Chem. 2001 May 24; 44(11):1658-65. PMID: 11356101.
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    124. Zuccotto F, Zvelebil M, Brun R, Chowdhury SF, Di Lucrezia R, Leal I, Maes L, Ruiz-Perez LM, Gonzalez Pacanowska D, Gilbert IH. Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase. Eur J Med Chem. 2001 May; 36(5):395-405. PMID: 11451529.
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    125. Girault S, Davioud-Charvet TE, Maes L, Dubremetz JF, Debreu MA, Landry V, Sergheraert C. Potent and specific inhibitors of trypanothione reductase from Trypanosoma cruzi: bis(2-aminodiphenylsulfides) for fluorescent labeling studies. Bioorg Med Chem. 2001 Apr; 9(4):837-46. PMID: 11354666.
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    126. François G, Timperman G, Holenz J, Aké Assi L, Geuder T, Maes L, Dubois J, Hanocq M, Bringmann G. Naphthylisoquinoline alkaloids exhibit strong growth-inhibiting activities against Plasmodium falciparum and P. berghei in vitro--structure-activity relationships of dioncophylline C. Ann Trop Med Parasitol. 1996 Apr; 90(2):115-23. PMID: 8762401.
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