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Dr Elias Georges

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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Fallatah O, Georges E. Apigenin-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum. Int J Antimicrob Agents. 2017 Nov; 50(5):673-677. PMID: 28807879.
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    2. Ambadipudi R, Georges E. Sequences in Linker-1 domain of the multidrug resistance associated protein (MRP1 or ABCC1) bind to tubulin and their binding is modulated by phosphorylation. Biochem Biophys Res Commun. 2017 Jan 22; 482(4):1001-1006. PMID: 27908733.
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    3. Edaye S, Tazoo D, Bohle DS, Georges E. 3-Iodo-4-aminoquinoline derivative sensitises resistant strains of Plasmodium falciparum to chloroquine. Int J Antimicrob Agents. 2016 Jun; 47(6):482-5. PMID: 27211211.
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    4. Edaye S, Tazoo D, Bohle DS, Georges E. 3-Halo Chloroquine Derivatives Overcome Plasmodium falciparum Chloroquine Resistance Transporter-Mediated Drug Resistance in P. falciparum. Antimicrob Agents Chemother. 2015 Dec; 59(12):7891-3. PMID: 26438496.
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    5. Edaye S, Georges E. Characterization of native PfABCG protein in Plasmodium falciparum. Biochem Pharmacol. 2015 Sep 15; 97(2):137-46. PMID: 26239803.
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    6. Edaye S, Reiling SJ, Leimanis ML, Wunderlich J, Rohrbach P, Georges E. A 2-amino quinoline, 5-(3-(2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid, interacts with PfMDR1 and inhibits its drug transport in Plasmodium falciparum. Mol Biochem Parasitol. 2014 Jun; 195(1):34-42. PMID: 24914817.
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    7. Georges E, Lian J, Laberge R. A tamoxifen derivative, N,N-diethyl-2-[4-(phenylmethyl) phenoxy] ethanamine, selectively targets P-glycoprotein-positive multidrug resistant Chinese hamster cells. Biochem Pharmacol. 2014 Jul 15; 90(2):107-14. PMID: 24821111.
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    8. Laberge RM, Ambadipudi R, Georges E. P-glycoprotein mediates the collateral sensitivity of multidrug resistant cells to steroid hormones. Biochem Biophys Res Commun. 2014 May 16; 447(4):574-9. PMID: 24747077.
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    9. Tripathy U, Giguère-Bisson M, Sangji MH, Bellemare MJ, Bohle DS, Georges E, Wiseman PW. Optimization of malaria detection based on third harmonic generation imaging of hemozoin. Anal Bioanal Chem. 2013 Jun; 405(16):5431-40. PMID: 23649925.
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    10. Yang Y, Li Z, Mo W, Ambadipudi R, Arnold RJ, Hrncirova P, Novotny MV, Georges E, Zhang JT. Human ABCC1 interacts and colocalizes with ATP synthase a, revealed by interactive proteomics analysis. J Proteome Res. 2012 Feb 03; 11(2):1364-72. PMID: 22188235.
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    11. Georges E, Bonneau AM, Prinos P. RNAi-mediated knockdown of a-enolase increases the sensitivity of tumor cells to antitubulin chemotherapeutics. Int J Biochem Mol Biol. 2011; 2(4):303-8. PMID: 22187664.
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    12. Leimanis ML, Karwatsky J, Georges E. Photoaffinity labeling of the multidrug resistance protein 2 (ABCC2/cMOAT) with a photoreactive analog of LTC(4). Int J Biochem Mol Biol. 2011; 2(1):39-46. PMID: 21968553.
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    13. Prinos P, Lacoste MC, Wong J, Bonneau AM, Georges E. Mutation of cysteine 21 inhibits nucleophosmin/B23 oligomerization and chaperone activity. Int J Biochem Mol Biol. 2011; 2(1):24-30. PMID: 21968505.
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    14. Laberge RM, Ambadipudi R, Georges E. P-glycoprotein (ABCB1) modulates collateral sensitivity of a multidrug resistant cell line to verapamil. Arch Biochem Biophys. 2009 Nov; 491(1-2):53-60. PMID: 19772851.
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    15. Bellemare MJ, Bohle DS, Brosseau CN, Georges E, Godbout M, Kelly J, Leimanis ML, Leonelli R, Olivier M, Smilkstein M. Autofluorescence of condensed heme aggregates in malaria pigment and its synthetic equivalent hematin anhydride (beta-hematin). J Phys Chem B. 2009 Jun 18; 113(24):8391-401. PMID: 19472980.
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    16. Bélisle JM, Costantino S, Leimanis ML, Bellemare MJ, Bohle DS, Georges E, Wiseman PW. Sensitive detection of malaria infection by third harmonic generation imaging. Biophys J. 2008 Feb 15; 94(4):L26-8. PMID: 18065455.
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    17. Georges E. The P-glycoprotein (ABCB1) linker domain encodes high-affinity binding sequences to alpha- and beta-tubulins. Biochemistry. 2007 Jun 26; 46(25):7337-42. PMID: 17530867.
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    18. Laberge RM, Karwatsky J, Lincoln MC, Leimanis ML, Georges E. Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress. Biochem Pharmacol. 2007 Jun 01; 73(11):1727-37. PMID: 17359940.
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    19. Leimanis ML, Georges E. ABCG2 membrane transporter in mature human erythrocytes is exclusively homodimer. Biochem Biophys Res Commun. 2007 Mar 09; 354(2):345-50. PMID: 17250810.
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    20. Fotie J, Bohle DS, Leimanis ML, Georges E, Rukunga G, Nkengfack AE. Lupeol long-chain fatty acid esters with antimalarial activity from Holarrhena floribunda. J Nat Prod. 2006 Jan; 69(1):62-7. PMID: 16441070.
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    21. Karwatsky J, Leimanis M, Cai J, Gros P, Georges E. The leucotriene C4 binding sites in multidrug resistance protein 1 (ABCC1) include the first membrane multiple spanning domain. Biochemistry. 2005 Jan 11; 44(1):340-51. PMID: 15628876.
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    22. Alqawi O, Bates S, Georges E. Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding. Biochem J. 2004 Sep 01; 382(Pt 2):711-6. PMID: 15139851.
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    23. Wang Y, Serfass L, Roy MO, Wong J, Bonneau AM, Georges E. Annexin-I expression modulates drug resistance in tumor cells. Biochem Biophys Res Commun. 2004 Feb 06; 314(2):565-70. PMID: 14733945.
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    24. Karwatsky JM, Georges E. Drug binding domains of MRP1 (ABCC1) as revealed by photoaffinity labeling. Curr Med Chem Anticancer Agents. 2004 Jan; 4(1):19-30. PMID: 14754409.
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    25. Alqawi O, Poelarends G, Konings WN, Georges E, Alqwai O. Photoaffinity labeling under non-energized conditions of a specific drug-binding site of the ABC multidrug transporter LmrA from Lactococcus lactis. Biochem Biophys Res Commun. 2003 Nov 21; 311(3):696-701. PMID: 14623328.
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    26. Karwatsky J, Lincoln MC, Georges E. A mechanism for P-glycoprotein-mediated apoptosis as revealed by verapamil hypersensitivity. Biochemistry. 2003 Oct 28; 42(42):12163-73. PMID: 14567677.
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    27. Gauthier C, Weber S, Alarco AM, Alqawi O, Daoud R, Georges E, Raymond M. Functional similarities and differences between Candida albicans Cdr1p and Cdr2p transporters. Antimicrob Agents Chemother. 2003 May; 47(5):1543-54. PMID: 12709320.
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    28. Alqawi O, Georges E. The multidrug resistance protein ABCC1 drug-binding domains show selective sensitivity to mild detergents. Biochem Biophys Res Commun. 2003 Apr 18; 303(4):1135-41. PMID: 12684054.
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    29. Karwatsky J, Daoud R, Cai J, Gros P, Georges E. Binding of a photoaffinity analogue of glutathione to MRP1 (ABCC1) within two cytoplasmic regions (L0 and L1) as well as transmembrane domains 10-11 and 16-17. Biochemistry. 2003 Mar 25; 42(11):3286-94. PMID: 12641460.
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    30. Cai J, Daoud R, Alqawi O, Georges E, Pelletier J, Gros P. Nucleotide binding and nucleotide hydrolysis properties of the ABC transporter MRP6 (ABCC6). Biochemistry. 2002 Jun 25; 41(25):8058-67. PMID: 12069597.
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    31. Cai J, Daoud R, Georges E, Gros P. Functional expression of multidrug resistance protein 1 in Pichia pastoris. Biochemistry. 2001 Jul 27; 40(28):8307-16. PMID: 11444977.
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    32. Daoud R, Julien M, Gros P, Georges E. Major photoaffinity drug binding sites in multidrug resistance protein 1 (MRP1) are within transmembrane domains 10-11 and 16-17. J Biol Chem. 2001 Apr 13; 276(15):12324-30. PMID: 11152467.
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    33. Daoud R, Kast C, Gros P, Georges E. Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1). Biochemistry. 2000 Dec 19; 39(50):15344-52. PMID: 11112520.
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    34. Daoud R, Desneves J, Deady LW, Tilley L, Scheper RJ, Gros P, Georges E. The multidrug resistance protein is photoaffinity labeled by a quinoline-based drug at multiple sites. Biochemistry. 2000 May 23; 39(20):6094-102. PMID: 10821682.
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    35. Vezmar M, Georges E. Reversal of MRP-mediated doxorubicin resistance with quinoline-based drugs. Biochem Pharmacol. 2000 May 15; 59(10):1245-52. PMID: 10736425.
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    36. Abrahem A, Certad G, Pan X, Georges E. Pleiotropic resistance to diverse antimalarials in actinomycin D-resistant Plasmodium falciparum. Biochem Pharmacol. 2000 May 01; 59(9):1123-32. PMID: 10704942.
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    37. Certad G, Abrahem A, Georges E. Cloning and partial characterization of the proteasome S4 ATPase from Plasmodium falciparum. Exp Parasitol. 1999 Nov; 93(3):123-31. PMID: 10529354.
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    38. Vezmar M, Georges E. Direct binding of chloroquine to the multidrug resistance protein (MRP): possible role for MRP in chloroquine drug transport and resistance in tumor cells. Biochem Pharmacol. 1998 Sep 15; 56(6):733-42. PMID: 9751078.
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    39. Vezmar M, Deady LW, Tilley L, Georges E. The quinoline-based drug, N-[4-[1-hydroxy-2-(dibutylamino)ethyl] quinolin-8-yl]-4-azidosalicylamide, photoaffinity labels the multidrug resistance protein (MRP) at a biologically relevant site. Biochem Biophys Res Commun. 1997 Dec 08; 241(1):104-11. PMID: 9405241.
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    40. Wang Y, Pan XQ, Lheureux F, Georges E. Overexpression of a 40-kDa protein in human multidrug resistant cells. Biochem Biophys Res Commun. 1997 Jul 18; 236(2):483-8. PMID: 9240465.
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    41. Pouliot JF, L'Heureux F, Liu Z, Prichard RK, Georges E. Reversal of P-glycoprotein-associated multidrug resistance by ivermectin. Biochem Pharmacol. 1997 Jan 10; 53(1):17-25. PMID: 8960059.
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    42. Wang Y, Georges E. N-ethylmaleimide increases P-glycoprotein photoaffinity labeling with iodoaryl-azidoprazosin in multidrug resistant cells. Anticancer Res. 1997 Jan-Feb; 17(1A):357-64. PMID: 9066677.
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    43. Panasci L, Jean-Claude BJ, Vasilescu D, Mustafa A, Damian S, Damian Z, Georges E, Liu Z, Batist G, Leyland-Jones B. Sensitization to doxorubicin resistance in breast cancer cell lines by tamoxifen and megestrol acetate. Biochem Pharmacol. 1996 Oct 11; 52(7):1097-102. PMID: 8831729.
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    44. Liu Z, Lheureux F, Pouliot JF, Heckel A, Bamberger U, Georges E. BIBW22 BS, potent multidrug resistance-reversing agent, binds directly to P-glycoprotein and accumulates in drug-resistant cells. Mol Pharmacol. 1996 Sep; 50(3):482-92. PMID: 8794885.
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    45. Nare B, Lubega G, Prichard RK, Georges E. p-Azidosalicyl-5-amino-6-phenoxybenzimidazole photolabels the N-terminal 63-103 amino acids of Haemonchus contortus beta-tubulin 1. J Biol Chem. 1996 Apr 12; 271(15):8575-81. PMID: 8621485.
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    46. Childs S, Yeh RL, Georges E, Ling V. Identification of a sister gene to P-glycoprotein. Cancer Res. 1995 May 15; 55(10):2029-34. PMID: 7538046.
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    47. Nare B, Liu Z, Prichard RK, Georges E. Benzimidazoles, potent anti-mitotic drugs: substrates for the P-glycoprotein transporter in multidrug-resistant cells. Biochem Pharmacol. 1994 Dec 16; 48(12):2215-22. PMID: 7811303.
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    48. Nare B, Prichard RK, Georges E. Characterization of rhodamine 123 binding to P-glycoprotein in human multidrug-resistant cells. Mol Pharmacol. 1994 Jun; 45(6):1145-52. PMID: 7912815.
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    49. Zordan-Nudo T, Ling V, Liu Z, Georges E. Effects of nonionic detergents on P-glycoprotein drug binding and reversal of multidrug resistance. Cancer Res. 1993 Dec 15; 53(24):5994-6000. PMID: 7903200.
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    50. Georges E, Tsuruo T, Ling V. Topology of P-glycoprotein as determined by epitope mapping of MRK-16 monoclonal antibody. J Biol Chem. 1993 Jan 25; 268(3):1792-8. PMID: 7678410.
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    51. Kellen JA, Georges E, Ling V, Dubsky M. Toremifene resistance in a rat mammary tumour model. Anticancer Res. 1992 Sep-Oct; 12(5):1663-5. PMID: 1359832.
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    52. Georges E, Zhang JT, Ling V. Modulation of ATP and drug binding by monoclonal antibodies against P-glycoprotein. J Cell Physiol. 1991 Sep; 148(3):479-84. PMID: 1680871.
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    53. Kellen JA, Wong A, Georges E, Ling V. R-verapamil decreases anti-estrogen resistance in a breast cancer model. Anticancer Res. 1991 Mar-Apr; 11(2):809-11. PMID: 1676580.
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    54. Bradley G, Georges E, Ling V. Sex-dependent and independent expression of the P-glycoprotein isoforms in Chinese hamster. J Cell Physiol. 1990 Dec; 145(3):398-408. PMID: 1703163.
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    55. Kawai K, Kamatani N, Georges E, Ling V. Identification of a membrane glycoprotein overexpressed in murine lymphoma sublines resistant to cis-diamminedichloroplatinum(II). J Biol Chem. 1990 Aug 05; 265(22):13137-42. PMID: 2376590.
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    56. Georges E, Bradley G, Gariepy J, Ling V. Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):152-6. PMID: 1688652.
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    57. Georges E, Sharom FJ, Ling V. Multidrug resistance and chemosensitization: therapeutic implications for cancer chemotherapy. Adv Pharmacol. 1990; 21:185-220. PMID: 2265126.
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    58. Georges E, Lindenbaum MH, Sacher MG, Trifaró JM, Mushynski WE. Neurofilament phosphorylation in cultured bovine adrenal chromaffin cells is stimulated by phorbol ester. J Neurochem. 1989 Apr; 52(4):1156-61. PMID: 2926395.
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    59. Greenberger LM, Williams SS, Georges E, Ling V, Horwitz SB. Electrophoretic analysis of P-glycoproteins produced by mouse J774.2 and Chinese hamster ovary multidrug-resistant cells. J Natl Cancer Inst. 1988 Jun 01; 80(7):506-10. PMID: 2896800.
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    60. Georges E, Trifaró JM, Mushynski WE. Hypophosphorylated neurofilament subunits in the cytoskeletal and soluble fractions of cultured bovine adrenal chromaffin cells. Neuroscience. 1987 Aug; 22(2):753-63. PMID: 3118238.
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    61. Georges E, Mushynski WE. Chemical modification of charged amino acid moieties alters the electrophoretic mobilities of neurofilament subunits on SDS/polyacrylamide gels. Eur J Biochem. 1987 Jun 01; 165(2):281-7. PMID: 3595591.
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    62. Georges E, Lefebvre S, Mushynski WE. Dephosphorylation of neurofilaments by exogenous phosphatases has no effect on reassembly of subunits. J Neurochem. 1986 Aug; 47(2):477-83. PMID: 3734790.
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    63. Bader MF, Georges E, Mushynski WE, Trifaró JM. Neurofilament proteins in cultured chromaffin cells. J Neurochem. 1984 Oct; 43(4):1180-93. PMID: 6432962.
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