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Professor Louis Schofield

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Robinson LJ, Wampfler R, Betuela I, Karl S, White MT, Li Wai Suen CS, Hofmann NE, Kinboro B, Waltmann A, Brewster J, Lorry L, Tarongka N, Samol L, Silkey M, Bassat Q, Siba PM, Schofield L, Felger I, Mueller I. Strategies for understanding and reducing the Plasmodium vivax and Plasmodium ovale hypnozoite reservoir in Papua New Guinean children: a randomised placebo-controlled trial and mathematical model. PLoS Med. 2015 Oct; 12(10):e1001891. PMID: 26505753; PMCID: PMC4624431.
    2. Roobsoong W, Tharinjaroen CS, Rachaphaew N, Chobson P, Schofield L, Cui L, Adams JH, Sattabongkot J. Improvement of culture conditions for long-term in vitro culture of Plasmodium vivax. Malar J. 2015 Aug 05; 14:297. PMID: 26243280; PMCID: PMC4524445.
    3. Srivastava A, Creek DJ, Evans KJ, De Souza D, Schofield L, Müller S, Barrett MP, McConville MJ, Waters AP. Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites. PLoS Pathog. 2015 Jun; 11(6):e1004882. PMID: 26042734; PMCID: PMC4456406.
    4. Eriksson EM, Schofield L. Dysfunctional ?d T cells: a contributing factor for clinical tolerance to malaria? Ann Transl Med. 2015 May; 3(Suppl 1):S34. PMID: 26046081; PMCID: PMC4437952.
    5. Chiu CY, Hodder AN, Lin CS, Hill DL, Li Wai Suen CS, Schofield L, Siba PM, Mueller I, Cowman AF, Hansen DS. Antibodies to the Plasmodium falciparum Proteins MSPDBL1 and MSPDBL2 Opsonize Merozoites, Inhibit Parasite Growth, and Predict Protection From Clinical Malaria. J Infect Dis. 2015 Aug 01; 212(3):406-15. PMID: 25646353.
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    6. Unger HW, Ome-Kaius M, Wangnapi RA, Umbers AJ, Hanieh S, Suen CS, Robinson LJ, Rosanas-Urgell A, Wapling J, Lufele E, Kongs C, Samol P, Sui D, Singirok D, Bardaji A, Schofield L, Menendez C, Betuela I, Siba P, Mueller I, Rogerson SJ. Sulphadoxine-pyrimethamine plus azithromycin for the prevention of low birthweight in Papua New Guinea: a randomised controlled trial. BMC Med. 2015 Jan 16; 13:9. PMID: 25591391; PMCID: PMC4305224.
    7. Stanisic DI, Fowkes FJ, Koinari M, Javati S, Lin E, Kiniboro B, Richards JS, Robinson LJ, Schofield L, Kazura JW, King CL, Zimmerman P, Felger I, Siba PM, Mueller I, Beeson JG. Acquisition of antibodies against Plasmodium falciparum merozoites and malaria immunity in young children and the influence of age, force of infection, and magnitude of response. Infect Immun. 2015 Feb; 83(2):646-60. PMID: 25422270; PMCID: PMC4294228.
    8. Hill DL, Eriksson EM, Schofield L. High yield purification of Plasmodium falciparum merozoites for use in opsonizing antibody assays. J Vis Exp. 2014 Jul 17; (89). PMID: 25078358; PMCID: PMC4217647.
    9. Chiu CY, Healer J, Thompson JK, Chen L, Kaul A, Savergave L, Raghuwanshi A, Li Wai Suen CS, Siba PM, Schofield L, Mueller I, Cowman AF, Hansen DS. Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria. Front Microbiol. 2014; 5:314. PMID: 25071730; PMCID: PMC4074990.
    10. Hansen DS, Ryg-Cornejo V, Ioannidis LJ, Chiu CY, Ly A, Nie CQ, Scalzo AA, Schofield L. The contribution of natural killer complex loci to the development of experimental cerebral malaria. PLoS One. 2014; 9(4):e93268. PMID: 24691125; PMCID: PMC3972225.
    11. Stanisic DI, Cutts J, Eriksson E, Fowkes FJ, Rosanas-Urgell A, Siba P, Laman M, Davis TM, Manning L, Mueller I, Schofield L. ?d T cells and CD14+ monocytes are predominant cellular sources of cytokines and chemokines associated with severe malaria. J Infect Dis. 2014 Jul 15; 210(2):295-305. PMID: 24523513.
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    12. Aguilar R, Magallon-Tejada A, Achtman AH, Moraleda C, Joice R, Cisteró P, Li Wai Suen CS, Nhabomba A, Macete E, Mueller I, Marti M, Alonso PL, Menéndez C, Schofield L, Mayor A. Molecular evidence for the localization of Plasmodium falciparum immature gametocytes in bone marrow. Blood. 2014 Feb 13; 123(7):959-66. PMID: 24335496; PMCID: PMC4067503.
    13. Hill DL, Eriksson EM, Li Wai Suen CS, Chiu CY, Ryg-Cornejo V, Robinson LJ, Siba PM, Mueller I, Hansen DS, Schofield L. Opsonising antibodies to P. falciparum merozoites associated with immunity to clinical malaria. PLoS One. 2013; 8(9):e74627. PMID: 24040299; PMCID: PMC3767630.
    14. Hill DL, Eriksson EM, Carmagnac AB, Wilson DW, Cowman AF, Hansen DS, Schofield L. Efficient measurement of opsonising antibodies to Plasmodium falciparum merozoites. PLoS One. 2012; 7(12):e51692. PMID: 23300556; PMCID: PMC3530572.
    15. Achtman AH, Pilat S, Law CW, Lynn DJ, Janot L, Mayer ML, Ma S, Kindrachuk J, Finlay BB, Brinkman FS, Smyth GK, Hancock RE, Schofield L. Effective adjunctive therapy by an innate defense regulatory peptide in a preclinical model of severe malaria. Sci Transl Med. 2012 May 23; 4(135):135ra64. PMID: 22623740.
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    16. Ryg-Cornejo V, Nie CQ, Bernard NJ, Lundie RJ, Evans KJ, Crabb BS, Schofield L, Hansen DS. NK cells and conventional dendritic cells engage in reciprocal activation for the induction of inflammatory responses during Plasmodium berghei ANKA infection. Immunobiology. 2013 Feb; 218(2):263-71. PMID: 22704523.
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    17. Senn N, Rarau P, Stanisic DI, Robinson L, Barnadas C, Manong D, Salib M, Iga J, Tarongka N, Ley S, Rosanas-Urgell A, Aponte JJ, Zimmerman PA, Beeson JG, Schofield L, Siba P, Rogerson SJ, Reeder JC, Mueller I. Intermittent preventive treatment for malaria in Papua New Guinean infants exposed to Plasmodium falciparum and P. vivax: a randomized controlled trial. PLoS Med. 2012; 9(3):e1001195. PMID: 22479155; PMCID: PMC3313928.
    18. Hansen DS, Schofield L. Natural regulatory T cells in malaria: host or parasite allies? PLoS Pathog. 2010 Apr 29; 6(4):e1000771. PMID: 20442856; PMCID: PMC2861684.
    19. Hunt NH, Grau GE, Engwerda C, Barnum SR, van der Heyde H, Hansen DS, Schofield L, Golenser J. Murine cerebral malaria: the whole story. Trends Parasitol. 2010 Jun; 26(6):272-4. PMID: 20382078.
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    20. Lin E, Kiniboro B, Gray L, Dobbie S, Robinson L, Laumaea A, Schöpflin S, Stanisic D, Betuela I, Blood-Zikursh M, Siba P, Felger I, Schofield L, Zimmerman P, Mueller I. Differential patterns of infection and disease with P. falciparum and P. vivax in young Papua New Guinean children. PLoS One. 2010 Feb 04; 5(2):e9047. PMID: 20140220; PMCID: PMC2816213.
    21. Shi W, de Graaf CA, Kinkel SA, Achtman AH, Baldwin T, Schofield L, Scott HS, Hilton DJ, Smyth GK. Estimating the proportion of microarray probes expressed in an RNA sample. Nucleic Acids Res. 2010 Apr; 38(7):2168-76. PMID: 20056656; PMCID: PMC2853118.
    22. Li S, Floess S, Hamann A, Gaudieri S, Lucas A, Hellard M, Roberts S, Paukovic G, Plebanski M, Loveland BE, Aitken C, Barry S, Schofield L, Gowans EJ. Analysis of FOXP3+ regulatory T cells that display apparent viral antigen specificity during chronic hepatitis C virus infection. PLoS Pathog. 2009 Dec; 5(12):e1000707. PMID: 20041222; PMCID: PMC2791198.
    23. D'Ombrain MC, Robinson LJ, Mueller I, Schofield L. Mechanisms underlying early interferon-gamma production in human Plasmodium falciparum malaria. Clin Infect Dis. 2009 May 15; 48(10):1482-3. PMID: 19374562.
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    24. Robinson LJ, D'Ombrain MC, Stanisic DI, Taraika J, Bernard N, Richards JS, Beeson JG, Tavul L, Michon P, Mueller I, Schofield L. Cellular tumor necrosis factor, gamma interferon, and interleukin-6 responses as correlates of immunity and risk of clinical Plasmodium falciparum malaria in children from Papua New Guinea. Infect Immun. 2009 Jul; 77(7):3033-43. PMID: 19380468; PMCID: PMC2708537.
    25. Nie CQ, Bernard NJ, Norman MU, Amante FH, Lundie RJ, Crabb BS, Heath WR, Engwerda CR, Hickey MJ, Schofield L, Hansen DS. IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection. PLoS Pathog. 2009 Apr; 5(4):e1000369. PMID: 19343215; PMCID: PMC2658824.
    26. D'Ombrain MC, Robinson LJ, Stanisic DI, Taraika J, Bernard N, Michon P, Mueller I, Schofield L. Association of early interferon-gamma production with immunity to clinical malaria: a longitudinal study among Papua New Guinean children. Clin Infect Dis. 2008 Dec 01; 47(11):1380-7. PMID: 18947328.
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    27. Lundie RJ, de Koning-Ward TF, Davey GM, Nie CQ, Hansen DS, Lau LS, Mintern JD, Belz GT, Schofield L, Carbone FR, Villadangos JA, Crabb BS, Heath WR. Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cells. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14509-14. PMID: 18799734; PMCID: PMC2567226.
    28. Caminschi I, Ahmet F, Heger K, Brady J, Nutt SL, Vremec D, Pietersz S, Lahoud MH, Schofield L, Hansen DS, O'Keeffe M, Smyth MJ, Bedoui S, Davey GM, Villadangos JA, Heath WR, Shortman K. Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells. J Exp Med. 2007 Oct 29; 204(11):2579-90. PMID: 17923506; PMCID: PMC2118479.
    29. Hansen DS, D'Ombrain MC, Schofield L. The role of leukocytes bearing Natural Killer Complex receptors and Killer Immunoglobulin-like Receptors in the immunology of malaria. Curr Opin Immunol. 2007 Aug; 19(4):416-23. PMID: 17702559.
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    30. D'Ombrain MC, Voss TS, Maier AG, Pearce JA, Hansen DS, Cowman AF, Schofield L. Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gamma. Cell Host Microbe. 2007 Aug 16; 2(2):130-8. PMID: 18005727.
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    31. D'Ombrain MC, Hansen DS, Simpson KM, Schofield L. gammadelta-T cells expressing NK receptors predominate over NK cells and conventional T cells in the innate IFN-gamma response to Plasmodium falciparum malaria. Eur J Immunol. 2007 Jul; 37(7):1864-73. PMID: 17557374.
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    32. Michon P, Cole-Tobian JL, Dabod E, Schoepflin S, Igu J, Susapu M, Tarongka N, Zimmerman PA, Reeder JC, Beeson JG, Schofield L, King CL, Mueller I. The risk of malarial infections and disease in Papua New Guinean children. Am J Trop Med Hyg. 2007 Jun; 76(6):997-1008. PMID: 17556601; PMCID: PMC3740942.
    33. Togbe D, Schofield L, Grau GE, Schnyder B, Boissay V, Charron S, Rose S, Beutler B, Quesniaux VF, Ryffel B. Murine cerebral malaria development is independent of toll-like receptor signaling. Am J Pathol. 2007 May; 170(5):1640-8. PMID: 17456769; PMCID: PMC1854958.
    34. Hansen DS, Bernard NJ, Nie CQ, Schofield L. NK cells stimulate recruitment of CXCR3+ T cells to the brain during Plasmodium berghei-mediated cerebral malaria. J Immunol. 2007 May 01; 178(9):5779-88. PMID: 17442962.
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    35. Nie CQ, Bernard NJ, Schofield L, Hansen DS. CD4+ CD25+ regulatory T cells suppress CD4+ T-cell function and inhibit the development of Plasmodium berghei-specific TH1 responses involved in cerebral malaria pathogenesis. Infect Immun. 2007 May; 75(5):2275-82. PMID: 17325053; PMCID: PMC1865737.
    36. Schofield L. Rational approaches to developing an anti-disease vaccine against malaria. Microbes Infect. 2007 May; 9(6):784-91. PMID: 17434329.
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    37. Schofield L. Intravascular infiltrates and organ-specific inflammation in malaria pathogenesis. Immunol Cell Biol. 2007 Feb-Mar; 85(2):130-7. PMID: 17344907.
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    38. Debierre-Grockiego F, Schofield L, Azzouz N, Schmidt J, Santos de Macedo C, Ferguson MA, Schwarz RT. Fatty acids from Plasmodium falciparum down-regulate the toxic activity of malaria glycosylphosphatidylinositols. Infect Immun. 2006 Oct; 74(10):5487-96. PMID: 16988223; PMCID: PMC1594897.
    39. Cromer D, Evans KJ, Schofield L, Davenport MP. Preferential invasion of reticulocytes during late-stage Plasmodium berghei infection accounts for reduced circulating reticulocyte levels. Int J Parasitol. 2006 Nov; 36(13):1389-97. PMID: 16979643.
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    40. Gilson PR, Nebl T, Vukcevic D, Moritz RL, Sargeant T, Speed TP, Schofield L, Crabb BS. Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum. Mol Cell Proteomics. 2006 Jul; 5(7):1286-99. PMID: 16603573.
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    41. Schofield L, Mueller I. Clinical immunity to malaria. Curr Mol Med. 2006 Mar; 6(2):205-21. PMID: 16515511.
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    42. Evans KJ, Hansen DS, van Rooijen N, Buckingham LA, Schofield L. Severe malarial anemia of low parasite burden in rodent models results from accelerated clearance of uninfected erythrocytes. Blood. 2006 Feb 01; 107(3):1192-9. PMID: 16210332; PMCID: PMC1895912.
    43. Sanders PR, Gilson PR, Cantin GT, Greenbaum DC, Nebl T, Carucci DJ, McConville MJ, Schofield L, Hodder AN, Yates JR, Crabb BS. Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum. J Biol Chem. 2005 Dec 02; 280(48):40169-76. PMID: 16203726.
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    44. Schofield L, Grau GE. Immunological processes in malaria pathogenesis. Nat Rev Immunol. 2005 Sep; 5(9):722-35. PMID: 16138104.
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    45. Wang L, Kedzierski L, Schofield L, Coppel RL. Influence of glycosylphosphatidylinositol anchorage on the efficacy of DNA vaccines encoding Plasmodium yoelii merozoite surface protein 4/5. Vaccine. 2005 Jul 14; 23(32):4120-7. PMID: 15964480.
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    46. Hansen DS, Evans KJ, D'Ombrain MC, Bernard NJ, Sexton AC, Buckingham L, Scalzo AA, Schofield L. The natural killer complex regulates severe malarial pathogenesis and influences acquired immune responses to Plasmodium berghei ANKA. Infect Immun. 2005 Apr; 73(4):2288-97. PMID: 15784573; PMCID: PMC1087422.
    47. Nebl T, De Veer MJ, Schofield L. Stimulation of innate immune responses by malarial glycosylphosphatidylinositol via pattern recognition receptors. Parasitology. 2005; 130 Suppl:S45-62. PMID: 16281992.
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    48. Sexton AC, Good RT, Hansen DS, D'Ombrain MC, Buckingham L, Simpson K, Schofield L. Transcriptional profiling reveals suppressed erythropoiesis, up-regulated glycolysis, and interferon-associated responses in murine malaria. J Infect Dis. 2004 Apr 01; 189(7):1245-56. PMID: 15031794.
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    49. Hansen DS, Schofield L. Regulation of immunity and pathogenesis in infectious diseases by CD1d-restricted NKT cells. Int J Parasitol. 2004 Jan; 34(1):15-25. PMID: 14711586.
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    50. de Veer MJ, Curtis JM, Baldwin TM, DiDonato JA, Sexton A, McConville MJ, Handman E, Schofield L. MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll-like receptor 2 signaling. Eur J Immunol. 2003 Oct; 33(10):2822-31. PMID: 14515266.
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    51. Hansen DS, Siomos MA, De Koning-Ward T, Buckingham L, Crabb BS, Schofield L. CD1d-restricted NKT cells contribute to malarial splenomegaly and enhance parasite-specific antibody responses. Eur J Immunol. 2003 Sep; 33(9):2588-98. PMID: 12938235.
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    52. Hansen DS, Siomos MA, Buckingham L, Scalzo AA, Schofield L. Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex. Immunity. 2003 Mar; 18(3):391-402. PMID: 12648456.
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    53. Bullen DV, Hansen DS, Siomos MA, Schofield L, Alexander WS, Handman E. The lack of suppressor of cytokine signalling-1 (SOCS1) protects mice from the development of cerebral malaria caused by Plasmodium berghei ANKA. Parasite Immunol. 2003 Mar; 25(3):113-8. PMID: 12911518.
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    54. Schofield L, Hewitt MC, Evans K, Siomos MA, Seeberger PH. Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria. Nature. 2002 Aug 15; 418(6899):785-9. PMID: 12181569.
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    55. Delorenzi M, Sexton A, Shams-Eldin H, Schwarz RT, Speed T, Schofield L. Genes for glycosylphosphatidylinositol toxin biosynthesis in Plasmodium falciparum. Infect Immun. 2002 Aug; 70(8):4510-22. PMID: 12117963; PMCID: PMC128142.
    56. Schofield L. Antidisease vaccines. Chem Immunol. 2002; 80:322-42. PMID: 12058648.
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    57. Tachado SD, Mazhari-Tabrizi R, Schofield L. Specificity in signal transduction among glycosylphosphatidylinositols of Plasmodium falciparum, Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. Parasite Immunol. 1999 Dec; 21(12):609-17. PMID: 10583863.
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    58. Berhe S, Schofield L, Schwarz RT, Gerold P. Conservation of structure among glycosylphosphatidylinositol toxins from different geographic isolates of Plasmodium falciparum. Mol Biochem Parasitol. 1999 Oct 15; 103(2):273-8. PMID: 10551370.
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    59. Schofield L, McConville MJ, Hansen D, Campbell AS, Fraser-Reid B, Grusby MJ, Tachado SD. CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells. Science. 1999 Jan 08; 283(5399):225-9. PMID: 9880256.
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    60. Tachado SD, Gerold P, Schwarz R, Novakovic S, McConville M, Schofield L. Signal transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):4022-7. PMID: 9108098; PMCID: PMC20561.
    61. Schofield L, Tachado SD. Regulation of host cell function by glycosylphosphatidylinositols of the parasitic protozoa. Immunol Cell Biol. 1996 Dec; 74(6):555-63. PMID: 8989594.
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