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Dr Richard Kingston Haynes

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. de Lange C, Coertzen D, Smit FJ, Wentzel JF, Wong HN, Birkholtz LM, Haynes RK, N'Da DD. Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids. Bioorg Med Chem Lett. 2018 10 15; 28(19):3161-3163. PMID: 30174153.
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    2. Coertzen D, Reader J, van der Watt M, Nondaba SH, Gibhard L, Wiesner L, Smith P, D'Alessandro S, Taramelli D, Wong HN, du Preez JL, Wu RWK, Birkholtz LM, Haynes RK. Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages. Antimicrob Agents Chemother. 2018 08; 62(8). PMID: 29866868.
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    3. Wu Y, Parapini S, Williams ID, Misiano P, Wong HN, Taramelli D, Basilico N, Haynes RK. Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities. Molecules. 2018 Jul 13; 23(7). PMID: 30011856.
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    4. Wu Y, Wu RW, Cheu KW, Williams ID, Krishna S, Slavic K, Gravett AM, Liu WM, Wong HN, Haynes RK. Methylene Homologues of Artemisone: An Unexpected Structure-Activity Relationship and a Possible Implication for the Design of C10-Substituted Artemisinins. ChemMedChem. 2016 07 05; 11(13):1469-79. PMID: 27273875.
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    5. Dwivedi A, Mazumder A, du Plessis L, du Preez JL, Haynes RK, du Plessis J. In vitro anti-cancer effects of artemisone nano-vesicular formulations on melanoma cells. Nanomedicine. 2015 Nov; 11(8):2041-50. PMID: 26282380.
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    6. Müller J, Balmer V, Winzer P, Rahman M, Manser V, Haynes RK, Hemphill A. In vitro effects of new artemisinin derivatives in Neospora caninum-infected human fibroblasts. Int J Antimicrob Agents. 2015 Jul; 46(1):88-93. PMID: 25934265.
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    7. Harmse R, Wong HN, Smit F, Haynes RK, N'Da DD. The Case for Development of 11-Aza-artemisinins for Malaria. Curr Med Chem. 2015; 22(31):3607-30. PMID: 26219389.
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    8. Grobler L, Chavchich M, Haynes RK, Edstein MD, Grobler AF. Assessment of the induction of dormant ring stages in Plasmodium falciparum parasites by artemisone and artemisone entrapped in Pheroid vesicles in vitro. Antimicrob Agents Chemother. 2014 Dec; 58(12):7579-82. PMID: 25288088.
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    9. Beteck RM, Smit FJ, Haynes RK, N'Da DD. Recent progress in the development of anti-malarial quinolones. Malar J. 2014 Aug 30; 13:339. PMID: 25176157.
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    10. Magenta D, Sangiovanni E, Basilico N, Haynes RK, Parapini S, Colombo E, Bosisio E, Taramelli D, Dell'Agli M. Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives. Acta Trop. 2014 Dec; 140:77-83. PMID: 25149353.
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    11. Guiguemde WA, Hunt NH, Guo J, Marciano A, Haynes RK, Clark J, Guy RK, Golenser J. Treatment of murine cerebral malaria by artemisone in combination with conventional antimalarial drugs: antiplasmodial effects and immune responses. Antimicrob Agents Chemother. 2014 Aug; 58(8):4745-54. PMID: 24913162.
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    12. Hooft van Huijsduijnen R, Guy RK, Chibale K, Haynes RK, Peitz I, Kelter G, Phillips MA, Vennerstrom JL, Yuthavong Y, Wells TN. Anticancer properties of distinct antimalarial drug classes. PLoS One. 2013; 8(12):e82962. PMID: 24391728.
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    13. Mazuz ML, Golenser J, Fish L, Haynes RK, Wollkomirsky R, Leibovich B, Shkap V. Artemisone inhibits in vitro and in vivo propagation of Babesia bovis and B. bigemina parasites. Exp Parasitol. 2013 Dec; 135(4):690-4. PMID: 24184077.
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    14. Waknine-Grinberg JH, Even-Chen S, Avichzer J, Turjeman K, Bentura-Marciano A, Haynes RK, Weiss L, Allon N, Ovadia H, Golenser J, Barenholz Y. Glucocorticosteroids in nano-sterically stabilized liposomes are efficacious for elimination of the acute symptoms of experimental cerebral malaria. PLoS One. 2013; 8(8):e72722. PMID: 23991146.
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    15. Haynes RK, Cheu KW, N'Da D, Coghi P, Monti D. Considerations on the mechanism of action of artemisinin antimalarials: part 1--the 'carbon radical' and 'heme' hypotheses. Infect Disord Drug Targets. 2013 Aug; 13(4):217-77. PMID: 24304352.
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    16. Pulcini S, Staines HM, Pittman JK, Slavic K, Doerig C, Halbert J, Tewari R, Shah F, Avery MA, Haynes RK, Krishna S. Expression in yeast links field polymorphisms in PfATP6 to in vitro artemisinin resistance and identifies new inhibitor classes. J Infect Dis. 2013 Aug 01; 208(3):468-78. PMID: 23599312.
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    17. Haynes RK, Cheu KW, Chan HW, Wong HN, Li KY, Tang MM, Chen MJ, Guo ZF, Guo ZH, Sinniah K, Witte AB, Coghi P, Monti D. Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model--a unifying proposal for drug action. ChemMedChem. 2012 Dec; 7(12):2204-26. PMID: 23112085.
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    18. Marfurt J, Chalfein F, Prayoga P, Wabiser F, Wirjanata G, Sebayang B, Piera KA, Wittlin S, Haynes RK, Möhrle JJ, Anstey NM, Kenangalem E, Price RN. Comparative ex vivo activity of novel endoperoxides in multidrug-resistant plasmodium falciparum and P. vivax. Antimicrob Agents Chemother. 2012 Oct; 56(10):5258-63. PMID: 22850522.
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    19. Finaurini S, Basilico N, Corbett Y, D'Alessandro S, Parapini S, Olliaro P, Haynes RK, Taramelli D. Dihydroartemisinin inhibits the human erythroid cell differentiation by altering the cell cycle. Toxicology. 2012 Oct 09; 300(1-2):57-66. PMID: 22677887.
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    20. Guo J, Guiguemde AW, Bentura-Marciano A, Clark J, Haynes RK, Chan WC, Wong HN, Hunt NH, Guy RK, Golenser J. Synthesis of artemiside and its effects in combination with conventional drugs against severe murine malaria. Antimicrob Agents Chemother. 2012 Jan; 56(1):163-73. PMID: 22006004.
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    21. Haynes RK, Cheu KW, Li KY, Tang MM, Wong HN, Chen MJ, Guo ZF, Guo ZH, Coghi P, Monti D. A partial convergence in action of methylene blue and artemisinins: antagonism with chloroquine, a reversal with verapamil, and an insight into the antimalarial activity of chloroquine. ChemMedChem. 2011 Sep 05; 6(9):1603-15. PMID: 21994127.
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    22. Steyn JD, Wiesner L, du Plessis LH, Grobler AF, Smith PJ, Chan WC, Haynes RK, Kotzé AF. Absorption of the novel artemisinin derivatives artemisone and artemiside: potential application of Pheroid™ technology. Int J Pharm. 2011 Jul 29; 414(1-2):260-6. PMID: 21596127.
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    23. Haynes RK, Cheu KW, Tang MM, Chen MJ, Guo ZF, Guo ZH, Coghi P, Monti D. Reactions of antimalarial peroxides with each of leucomethylene blue and dihydroflavins: flavin reductase and the cofactor model exemplified. ChemMedChem. 2011 Feb 07; 6(2):279-91. PMID: 21275052.
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    24. Pooley S, Fatih FA, Krishna S, Gerisch M, Haynes RK, Wong HN, Staines HM. Artemisone uptake in Plasmodium falciparum-infected erythrocytes. Antimicrob Agents Chemother. 2011 Feb; 55(2):550-6. PMID: 21135191.
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    25. Waknine-Grinberg JH, Hunt N, Bentura-Marciano A, McQuillan JA, Chan HW, Chan WC, Barenholz Y, Haynes RK, Golenser J. Artemisone effective against murine cerebral malaria. Malar J. 2010 Aug 09; 9:227. PMID: 20691118.
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    26. Haynes RK, Chan WC, Wong HN, Li KY, Wu WK, Fan KM, Sung HH, Williams ID, Prosperi D, Melato S, Coghi P, Monti D. Facile oxidation of leucomethylene blue and dihydroflavins by artemisinins: relationship with flavoenzyme function and antimalarial mechanism of action. ChemMedChem. 2010 Aug 02; 5(8):1282-99. PMID: 20629071.
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    27. Gravett AM, Liu WM, Krishna S, Chan WC, Haynes RK, Wilson NL, Dalgleish AG. In vitro study of the anti-cancer effects of artemisone alone or in combination with other chemotherapeutic agents. Cancer Chemother Pharmacol. 2011 Mar; 67(3):569-77. PMID: 20490800.
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    28. Coghi P, Basilico N, Taramelli D, Chan WC, Haynes RK, Monti D. Interaction of artemisinins with oxyhemoglobin Hb-FeII, Hb-FeII, carboxyHb-FeII, heme-FeII, and carboxyheme FeII: significance for mode of action and implications for therapy of cerebral malaria. ChemMedChem. 2009 Dec; 4(12):2045-53. PMID: 19844934.
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    29. Dunay IR, Chan WC, Haynes RK, Sibley LD. Artemisone and artemiside control acute and reactivated toxoplasmosis in a murine model. Antimicrob Agents Chemother. 2009 Oct; 53(10):4450-6. PMID: 19635951.
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    30. Obaldia N, Kotecka BM, Edstein MD, Haynes RK, Fugmann B, Kyle DE, Rieckmann KH. Evaluation of artemisone combinations in Aotus monkeys infected with Plasmodium falciparum. Antimicrob Agents Chemother. 2009 Aug; 53(8):3592-4. PMID: 19506062.
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    31. Krishna S, Bustamante L, Haynes RK, Staines HM. Artemisinins: their growing importance in medicine. Trends Pharmacol Sci. 2008 Oct; 29(10):520-7. PMID: 18752857.
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    32. Nagelschmitz J, Voith B, Wensing G, Roemer A, Fugmann B, Haynes RK, Kotecka BM, Rieckmann KH, Edstein MD. First assessment in humans of the safety, tolerability, pharmacokinetics, and ex vivo pharmacodynamic antimalarial activity of the new artemisinin derivative artemisone. Antimicrob Agents Chemother. 2008 Sep; 52(9):3085-91. PMID: 18559649.
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    33. Haynes RK, Wong HN, Lee KW, Lung CM, Shek LY, Williams ID, Croft SL, Vivas L, Rattray L, Stewart L, Wong VK, Ko BC. Preparation of N-sulfonyl- and N-carbonyl-11-azaartemisinins with greatly enhanced thermal stabilities: in vitro antimalarial activities. ChemMedChem. 2007 Oct; 2(10):1464-79. PMID: 17768731.
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    34. Haynes RK, Chan HW, Lung CM, Ng NC, Wong HN, Shek LY, Williams ID, Cartwright A, Gomes MF. Artesunate and dihydroartemisinin (DHA): unusual decomposition products formed under mild conditions and comments on the fitness of DHA as an antimalarial drug. ChemMedChem. 2007 Oct; 2(10):1448-63. PMID: 17694524.
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    35. Haynes RK, Chan WC, Lung CM, Uhlemann AC, Eckstein U, Taramelli D, Parapini S, Monti D, Krishna S. The Fe2+-mediated decomposition, PfATP6 binding, and antimalarial activities of artemisone and other artemisinins: the unlikelihood of C-centered radicals as bioactive intermediates. ChemMedChem. 2007 Oct; 2(10):1480-97. PMID: 17768732.
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    36. D'Alessandro S, Gelati M, Basilico N, Parati EA, Haynes RK, Taramelli D. Differential effects on angiogenesis of two antimalarial compounds, dihydroartemisinin and artemisone: implications for embryotoxicity. Toxicology. 2007 Nov 20; 241(1-2):66-74. PMID: 17897768.
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    37. Mishina YV, Krishna S, Haynes RK, Meade JC. Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth. Antimicrob Agents Chemother. 2007 May; 51(5):1852-4. PMID: 17339374.
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    38. Vivas L, Rattray L, Stewart LB, Robinson BL, Fugmann B, Haynes RK, Peters W, Croft SL. Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo. J Antimicrob Chemother. 2007 Apr; 59(4):658-65. PMID: 17337512.
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    39. Krishna S, Woodrow CJ, Staines HM, Haynes RK, Mercereau-Puijalon O. Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance. Trends Mol Med. 2006 May; 12(5):200-5. PMID: 16616639.
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    40. Haynes RK, Fugmann B, Stetter J, Rieckmann K, Heilmann HD, Chan HW, Cheung MK, Lam WL, Wong HN, Croft SL, Vivas L, Rattray L, Stewart L, Peters W, Robinson BL, Edstein MD, Kotecka B, Kyle DE, Beckermann B, Gerisch M, Radtke M, Schmuck G, Steinke W, Wollborn U, Schmeer K, Römer A. Artemisone--a highly active antimalarial drug of the artemisinin class. Angew Chem Int Ed Engl. 2006 Mar 20; 45(13):2082-8. PMID: 16444785.
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    41. Haynes RK. From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements. Curr Top Med Chem. 2006; 6(5):509-37. PMID: 16719805.
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    42. Uhlemann AC, Cameron A, Eckstein-Ludwig U, Fischbarg J, Iserovich P, Zuniga FA, East M, Lee A, Brady L, Haynes RK, Krishna S. A single amino acid residue can determine the sensitivity of SERCAs to artemisinins. Nat Struct Mol Biol. 2005 Jul; 12(7):628-9. PMID: 15937493.
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    43. Haynes RK, Chan HW, Ho WY, Ko CK, Gerena L, Kyle DE, Peters W, Robinson BL. Convenient access both to highly antimalaria-active 10-arylaminoartemisinins, and to 10-alkyl ethers including artemether, arteether, and artelinate. Chembiochem. 2005 Apr; 6(4):659-67. PMID: 15812783.
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    44. Ji JX, Wu J, Au-Yeung TT, Yip CW, Haynes RK, Chan AS. Highly enantioselective phenyl transfer to aryl aldehydes catalyzed by easily accessible chiral tertiary aminonaphthol. J Org Chem. 2005 Feb 04; 70(3):1093-5. PMID: 15675881.
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    45. Woodrow CJ, Haynes RK, Krishna S. Artemisinins. Postgrad Med J. 2005 Feb; 81(952):71-8. PMID: 15701735.
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    46. Haynes RK, Krishna S. Artemisinins: activities and actions. Microbes Infect. 2004 Nov; 6(14):1339-46. PMID: 15555542.
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    47. Chan EY, Zhang QF, Sau YK, Lo SM, Sung HH, Williams ID, Haynes RK, Leung WH. Chiral bisphosphinite metalloligands derived from a P-chiral secondary phosphine oxide. Inorg Chem. 2004 Aug 09; 43(16):4921-6. PMID: 15285668.
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    48. Krishna S, Uhlemann AC, Haynes RK. Artemisinins: mechanisms of action and potential for resistance. Drug Resist Updat. 2004 Aug-Oct; 7(4-5):233-44. PMID: 15533761.
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    49. Haynes RK, Ho WY, Chan HW, Fugmann B, Stetter J, Croft SL, Vivas L, Peters W, Robinson BL. Highly antimalaria-active artemisinin derivatives: biological activity does not correlate with chemical reactivity. Angew Chem Int Ed Engl. 2004 Mar 05; 43(11):1381-5. PMID: 15368412.
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    50. Haynes RK, Monti D, Taramelli D, Basilico N, Parapini S, Olliaro P. Artemisinin antimalarials do not inhibit hemozoin formation. Antimicrob Agents Chemother. 2003 Mar; 47(3):1175. PMID: 12604568.
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    51. Schmuck G, Roehrdanz E, Haynes RK, Kahl R. Neurotoxic mode of action of artemisinin. Antimicrob Agents Chemother. 2002 Mar; 46(3):821-7. PMID: 11850267.
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    52. Haynes RK. Artemisinin and derivatives: the future for malaria treatment? Curr Opin Infect Dis. 2001 Dec; 14(6):719-26. PMID: 11964891.
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    53. Olliaro PL, Haynes RK, Meunier B, Yuthavong Y. Possible modes of action of the artemisinin-type compounds. Trends Parasitol. 2001 Mar; 17(3):122-6. PMID: 11286794.
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    54. Schmuck G, Haynes RK. Establishment of an in vitro screening model for neurodegeneration induced by antimalarial drugs of the artemisinin-type.. Neurotox Res. 2000; 2(1):37-49. PMID: 15545005.
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    55. Mohamed SS, Khalid SA, Ward SA, Wan TS, Tang HP, Zheng M, Haynes RK, Edwards G. Simultaneous determination of artemether and its major metabolite dihydroartemisinin in plasma by gas chromatography-mass spectrometry-selected ion monitoring. J Chromatogr B Biomed Sci Appl. 1999 Aug 20; 731(2):251-60. PMID: 10510778.
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    56. Haynes RK, Vonwiller SC. Extraction of artemisinin and artemisinic acid: preparation of artemether and new analogues. Trans R Soc Trop Med Hyg. 1994 Jun; 88 Suppl 1:S23-6. PMID: 8053018.
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