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Professor Gary Posner

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Conyers RC, Mazzone JR, Tripathi AK, Sullivan DJ, Posner GH. Antimalarial chemotherapy: orally curative artemisinin-derived trioxane dimer esters. Bioorg Med Chem Lett. 2015 Jan 15; 25(2):245-8. PMID: 25481079; PMCID: PMC4277730.
    2. Mazzone JR, Conyers RC, Tripathi AK, Sullivan DJ, Posner GH. Antimalarial chemotherapy: artemisinin-derived dimer carbonates and thiocarbonates. Bioorg Med Chem Lett. 2014 Jun 01; 24(11):2440-3. PMID: 24775306; PMCID: PMC4074917.
    3. Conyers RC, Mazzone JR, Siegler MA, Tripathi AK, Sullivan DJ, Mott BT, Posner GH. The survival times of malaria-infected mice are prolonged more by several new two-carbon-linked artemisinin-derived dimer carbamates than by the trioxane antimalarial drug artemether. Bioorg Med Chem Lett. 2014 Mar 01; 24(5):1285-9. PMID: 24508128; PMCID: PMC3943161.
    4. Woodard LE, Mott BT, Singhal V, Kumar N, Shapiro TA, Posner GH. Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine. Pharmaceuticals (Basel). 2009 Dec 21; 2(3):228-235. PMID: 27713236.
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    5. Posner GH, Maio WA, Kalinda AS. Electronically stabilized versions of the antimalarial acetal trioxanes artemether and artesunate. Bioorg Med Chem. 2008 May 01; 16(9):5247-53. PMID: 18353653; PMCID: PMC2668193.
    6. Posner GH, Chang W, Hess L, Woodard L, Sinishtaj S, Usera AR, Maio W, Rosenthal AS, Kalinda AS, D'Angelo JG, Petersen KS, Stohler R, Chollet J, Santo-Tomas J, Snyder C, Rottmann M, Wittlin S, Brun R, Shapiro TA. Malaria-infected mice are cured by oral administration of new artemisinin derivatives. J Med Chem. 2008 Feb 28; 51(4):1035-42. PMID: 18232653.
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    7. Posner GH, Paik IH, Chang W, Borstnik K, Sinishtaj S, Rosenthal AS, Shapiro TA. Malaria-infected mice are cured by a single dose of novel artemisinin derivatives. J Med Chem. 2007 May 17; 50(10):2516-9. PMID: 17439113.
      View in: PubMed
    8. Posner GH, Suh BC, Petersen KS, Dolan P, Agoston ES, Kensler TW, Koh JT, Peleg S. Difluoromethyl analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):213-21. PMID: 17218093; PMCID: PMC2712873.
    9. Posner GH, Kim HJ, Kahraman M, Jeon HB, Suh BC, Li H, Dolan P, Kensler TW. Highly antiproliferative, low-calcemic, side-chain ketone analogs of the hormone 1alpha,25-dihydroxyvitamin D3. Bioorg Med Chem. 2005 Oct 01; 13(19):5569-80. PMID: 16039132.
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    10. Posner GH, Hatcher MA, Maio WA. New silicon-mediated, sequential ring expansions of n-sized 2-cycloalkenones into hydroxyolefinic n + m + p medium-sized lactones: short synthesis of (-)-phoracantholide-J. Org Lett. 2005 Sep 15; 7(19):4301-3. PMID: 16146412.
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    11. Posner GH, Lee SH, Kim HJ, Peleg S, Dolan P, Kensler TW. Novel A-ring analogs of the hormone 1alpha,25-dihydroxyvitamin D3: synthesis and preliminary biological evaluation. Bioorg Med Chem. 2005 Apr 15; 13(8):2959-66. PMID: 15781405.
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    12. Posner GH, Jeon HB, Sarjeant A, Riccio ES, Doppalapudi RS, Kapetanovic IM, Saha U, Dolan P, Kensler TW. Low-calcemic, efficacious, 1alpha,25-dihydroxyvitamin D3 analog QW-1624F2-2: calcemic dose-response determination, preclinical genotoxicity testing, and revision of A-ring stereochemistry. Steroids. 2004 Oct-Nov; 69(11-12):757-62. PMID: 15579327.
      View in: PubMed
    13. Posner GH, O'Neill PM. Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides. Acc Chem Res. 2004 Jun; 37(6):397-404. PMID: 15196049.
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    14. Posner GH, Crawford KR, Yang HW, Kahraman M, Jeon HB, Li H, Lee JK, Suh BC, Hatcher MA, Labonte T, Usera A, Dolan PM, Kensler TW, Peleg S, Jones G, Zhang A, Korczak B, Saha U, Chuang SS. Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1alpha,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):5-12. PMID: 15225738.
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    15. Posner GH, McRiner AJ, Paik IH, Sur S, Borstnik K, Xie S, Shapiro TA, Alagbala A, Foster B. Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents. J Med Chem. 2004 Feb 26; 47(5):1299-301. PMID: 14971910.
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    16. Posner GH, Maxwell JP, Kahraman M. Mild, fast, and stereoselective epoxide opening by ketone enolate anions. Application to synthesis of the norlignan curculigine. J Org Chem. 2003 Apr 18; 68(8):3049-54. PMID: 12688771.
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    17. Posner GH, Paik IH, Sur S, McRiner AJ, Borstnik K, Xie S, Shapiro TA. Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy. J Med Chem. 2003 Mar 13; 46(6):1060-5. PMID: 12620083.
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    18. Posner GH. Low-calcemic vitamin D analogs (deltanoids) for human cancer prevention. J Nutr. 2002 Dec; 132(12):3802S-3803S. PMID: 12468627.
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    19. Posner GH, Halford BA, Peleg S, Dolan P, Kensler TW. Conceptually new low-calcemic oxime analogues of the hormone 1 alpha,25-dihydroxyvitamin D(3): synthesis and biological testing. J Med Chem. 2002 Apr 11; 45(8):1723-30. PMID: 11931627.
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    20. Posner GH, Crawford KR, Peleg S, Welsh JE, Romu S, Gewirtz DA, Gupta MS, Dolan P, Kensler TW. A non-calcemic sulfone version of the vitamin D(3) analogue seocalcitol (EB 1089): chemical synthesis, biological evaluation and potency enhancement of the anticancer drug adriamycin. Bioorg Med Chem. 2001 Sep; 9(9):2365-71. PMID: 11553477.
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    21. Posner GH, Crawford K, Siu-Caldera ML, Reddy GS, Sarabia SF, Feldman D, van Etten E, Mathieu C, Gennaro L, Vouros P, Peleg S, Dolan PM, Kensler TW. Conceptually new 20-epi-22-oxa sulfone analogues of the hormone 1alpha,25-dihydroxyvitamin D(3): synthesis and biological evaluation. J Med Chem. 2000 Sep 21; 43(19):3581-6. PMID: 11000014.
      View in: PubMed
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