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Professor Sharif Mahsufi Mansor

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Goh TB, Mordi MN, Mas Haris MR, Mansor SM. NMR structural assignments for four new 6-methoxy-tetrahydro-ß-carboline derivatives. Magn Reson Chem. 2015 Oct; 53(10):857-9. PMID: 26137893.
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    2. Ilmie MU, Jaafar H, Mansor SM, Abdullah JM. Subchronic toxicity study of standardized methanolic extract of Mitragyna speciosa Korth in Sprague-Dawley Rats. Front Neurosci. 2015; 9:189. PMID: 26136645; PMCID: PMC4470260.
    3. Singh D, Müller CP, Vicknasingam BK, Mansor SM. Social Functioning of Kratom (Mitragyna speciosa) Users in Malaysia. J Psychoactive Drugs. 2015 Apr-Jun; 47(2):125-31. PMID: 25950592.
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    4. Goh TB, Koh RY, Yam MF, Azhar ME, Mordi MN, Mansor SM. 5-Methoxytryptamine reacts with natural food flavour to produce 6-methoxy tetrahydro-ß-carbolines: in vitro investigation of their antioxidant and cytotoxicity properties. Food Chem. 2015 Sep 15; 183:208-16. PMID: 25863630.
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    5. Ramanathan S, Parthasarathy S, Murugaiyah V, Magosso E, Tan SC, Mansor SM. Understanding the physicochemical properties of mitragynine, a principal alkaloid of Mitragyna speciosa, for preclinical evaluation. Molecules. 2015 Mar 18; 20(3):4915-27. PMID: 25793541.
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    6. Harun N, Hassan Z, Navaratnam V, Mansor SM, Shoaib M. Discriminative stimulus properties of mitragynine (kratom) in rats. Psychopharmacology (Berl). 2015 Jul; 232(13):2227-38. PMID: 25616583.
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    7. Kamilla L, Ramanathan S, Sasidharan S, Mansor SM. Evaluation of antinociceptive effect of methanolic leaf and root extracts of Clitoria ternatea Linn. in rats. Indian J Pharmacol. 2014 Sep-Oct; 46(5):515-20. PMID: 25298581; PMCID: PMC4175888.
    8. Hazim AI, Ramanathan S, Parthasarathy S, Muzaimi M, Mansor SM. Anxiolytic-like effects of mitragynine in the open-field and elevated plus-maze tests in rats. J Physiol Sci. 2014 May; 64(3):161-9. PMID: 24464759.
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    9. Goh TB, Koh RY, Mordi MN, Mansor SM. Antioxidant value and antiproliferative efficacy of mitragynine and a silane reduced analogue. Asian Pac J Cancer Prev. 2014; 15(14):5659-65. PMID: 25081682.
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    10. Hanapi NA, Ismail S, Mansor SM. Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities. Pharmacognosy Res. 2013 Oct; 5(4):241-6. PMID: 24174816; PMCID: PMC3807987.
    11. Sabetghadam A, Ramanathan S, Sasidharan S, Mansor SM. Subchronic exposure to mitragynine, the principal alkaloid of Mitragyna speciosa, in rats. J Ethnopharmacol. 2013 Apr 19; 146(3):815-23. PMID: 23422336.
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    12. Parthasarathy S, Ramanathan S, Murugaiyah V, Hamdan MR, Said MI, Lai CS, Mansor SM. A simple HPLC-DAD method for the detection and quantification of psychotropic mitragynine in Mitragyna speciosa (ketum) and its products for the application in forensic investigation. Forensic Sci Int. 2013 Mar 10; 226(1-3):183-7. PMID: 23385139.
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    13. Aruldass CA, Marimuthu MM, Ramanathan S, Mansor SM, Murugaiyah V. Effects of Mesua ferrea leaf and fruit extracts on growth and morphology of Staphylococcus aureus. Microsc Microanal. 2013 Feb; 19(1):254-60. PMID: 23332129.
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    14. Azizi J, Ismail S, Mansor SM. Mitragyna speciosa Korth leaves extracts induced the CYP450 catalyzed aminopyrine-N-demethylase (APND) and UDP-glucuronosyl transferase (UGT) activities in male Sprague-Dawley rat livers. Drug Metabol Drug Interact. 2013; 28(2):95-105. PMID: 23435185.
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    15. Hassan Z, Muzaimi M, Navaratnam V, Yusoff NH, Suhaimi FW, Vadivelu R, Vicknasingam BK, Amato D, von Hörsten S, Ismail NI, Jayabalan N, Hazim AI, Mansor SM, Müller CP. From Kratom to mitragynine and its derivatives: physiological and behavioural effects related to use, abuse, and addiction. Neurosci Biobehav Rev. 2013 Feb; 37(2):138-51. PMID: 23206666.
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    16. Mustaffa F, Indurkar J, Shah M, Ismail S, Mansor SM. Review on pharmacological activities of Cinnamomum iners Reinw. ex Blume. Nat Prod Res. 2013; 27(10):888-95. PMID: 22574706.
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    17. Annegowda HV, Bhat R, Min-Tze L, Karim AA, Mansor SM. Influence of sonication treatments and extraction solvents on the phenolics and antioxidants in star fruits. J Food Sci Technol. 2012 Aug; 49(4):510-4. PMID: 23904662; PMCID: PMC3550895.
    18. Annegowda HV, Bhat R, Tze LM, Karim AA, Mansor SM. The free radical scavenging and antioxidant activities of pod and seed extract of Clitoria fairchildiana (Howard)- an underutilized legume. J Food Sci Technol. 2013 Jun; 50(3):535-41. PMID: 24425949; PMCID: PMC3602564.
    19. Mustaffa F, Indurkar J, Ismail S, Shah M, Mansor SM. An antimicrobial compound isolated from Cinnamomum iners leaves with activity against methicillin-resistant Staphylococcus aureus. Molecules. 2011 Apr 08; 16(4):3037-47. PMID: 21478819.
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    20. Sahgal G, Ramanathan S, Sasidharan S, Mordi MN, Ismail S, Mansor SM. In vitro and in vivo anticandidal activity of Swietenia mahogani methanolic seed extract. Trop Biomed. 2011 Apr; 28(1):132-7. PMID: 21602779.
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    21. Annegowda HV, Anwar LN, Mordi MN, Ramanathan S, Mansor SM. Influence of sonication on the phenolic content and antioxidant activity of Terminalia catappa L. leaves. Pharmacognosy Res. 2010 Nov; 2(6):368-73. PMID: 21713141; PMCID: PMC3111697.
    22. Harizal SN, Mansor SM, Hasnan J, Tharakan JK, Abdullah J. Acute toxicity study of the standardized methanolic extract of Mitragyna speciosa Korth in rodent. J Ethnopharmacol. 2010 Sep 15; 131(2):404-9. PMID: 20643198.
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    23. Sahgal G, Ramanathan S, Sasidharan S, Mordi MN, Ismail S, Mansor SM. Brine shrimp lethality and acute oral toxicity studies on Swietenia mahagoni (Linn.) Jacq. seed methanolic extract. Pharmacognosy Res. 2010 Jul; 2(4):215-20. PMID: 21808570; PMCID: PMC3141130.
    24. Venkatesh G, Majid MI, Mansor SM, Nair NK, Croft SL, Navaratnam V. In vitro and in vivo evaluation of self-microemulsifying drug delivery system of buparvaquone. Drug Dev Ind Pharm. 2010 Jun; 36(6):735-45. PMID: 20136493.
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    25. Parthasarathy S, Ramanathan S, Ismail S, Adenan MI, Mansor SM, Murugaiyah V. Determination of mitragynine in plasma with solid-phase extraction and rapid HPLC-UV analysis, and its application to a pharmacokinetic study in rat. Anal Bioanal Chem. 2010 Jul; 397(5):2023-30. PMID: 20454783.
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    26. Al Azzam KM, Makahleah A, Saad B, Mansor SM. Hollow fiber liquid-phase microextraction for the determination of trace amounts of rosiglitazone (anti-diabetic drug) in biological fluids using capillary electrophoresis and high performance liquid chromatographic methods. J Chromatogr A. 2010 Jun 04; 1217(23):3654-9. PMID: 20409552.
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    27. Mustaffa F, Indurkar J, Ismail S, Mordi MN, Ramanathan S, Mansor SM. Analgesic activity, toxicity study and phytochemical screening of standardized Cinnomomum iners leaves methanolic extract. Pharmacognosy Res. 2010 Mar; 2(2):76-81. PMID: 21808545; PMCID: PMC3140111.
    28. Vicknasingam B, Narayanan S, Beng GT, Mansor SM. The informal use of ketum (Mitragyna speciosa) for opioid withdrawal in the northern states of peninsular Malaysia and implications for drug substitution therapy. Int J Drug Policy. 2010 Jul; 21(4):283-8. PMID: 20092998.
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    29. Azizi J, Ismail S, Mordi MN, Ramanathan S, Said MI, Mansor SM. In vitro and in vivo effects of three different Mitragyna speciosa korth leaf extracts on phase II drug metabolizing enzymes--glutathione transferases (GSTs). Molecules. 2010 Jan 20; 15(1):432-41. PMID: 20110902.
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    30. Sahgal G, Ramanathan S, Sasidharan S, Mordi MN, Ismail S, Mansor SM. Phytochemical and antimicrobial activity of Swietenia mahagoni crude methanolic seed extract. Trop Biomed. 2009 Dec; 26(3):274-9. PMID: 20237441.
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    31. Sahgal G, Ramanathan S, Sasidharan S, Mordi MN, Ismail S, Mansor SM. In Vitro antioxidant and xanthine oxidase inhibitory activities of methanolic Swietenia mahagoni seed extracts. Molecules. 2009 Nov 06; 14(11):4476-85. PMID: 19924080.
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    32. Lai CS, Mas RH, Nair NK, Mansor SM, Navaratnam V. Chemical constituents and in vitro anticancer activity of Typhonium flagelliforme (Araceae). J Ethnopharmacol. 2010 Feb 03; 127(2):486-94. PMID: 19833183.
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    33. Parthasarathy S, Bin Azizi J, Ramanathan S, Ismail S, Sasidharan S, Said MI, Mansor SM. Evaluation of antioxidant and antibacterial activities of aqueous, methanolic and alkaloid extracts from Mitragyna speciosa (Rubiaceae family) leaves. Molecules. 2009 Oct 09; 14(10):3964-74. PMID: 19924042.
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    34. Sathasivam K, Ramanathan S, Mansor SM, Haris MR, Wernsdorfer WH. Thrombocyte counts in mice after the administration of papaya leaf suspension. Wien Klin Wochenschr. 2009 Oct; 121 Suppl 3:19-22. PMID: 19915811.
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    35. Kamilla L, Mansor SM, Ramanathan S, Sasidharan S. Effects of Clitoria ternatea leaf extract on growth and morphogenesis of Aspergillus niger. Microsc Microanal. 2009 Aug; 15(4):366-72. PMID: 19575837.
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    36. Navaratnam V, Ramanathan S, Wahab MS, Siew Hua G, Mansor SM, Kiechel JR, Vaillant M, Taylor WR, Olliaro P. Tolerability and pharmacokinetics of non-fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers. Eur J Clin Pharmacol. 2009 Aug; 65(8):809-21. PMID: 19404632; PMCID: PMC2714898.
    37. Lai CS, Nair NK, Muniandy A, Mansor SM, Olliaro PL, Navaratnam V. Validation of high performance liquid chromatography-electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in clinical pharmacological studies of artesunate-amodiaquine drug combination. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 15; 877(5-6):558-62. PMID: 19147417.
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    38. Chee JW, Amirul AA, Majid MI, Mansor SM. Factors influencing the release of Mitragyna speciosa crude extracts from biodegradable P(3HB-co-4HB). Int J Pharm. 2008 Sep 01; 361(1-2):1-6. PMID: 18584978.
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    39. Venkatesh G, Majid MI, Ramanathan S, Mansor SM, Nair NK, Croft SL, Navaratnam V. Optimization and validation of RP-HPLC-UV method with solid-phase extraction for determination of buparvaquone in human and rabbit plasma: application to pharmacokinetic study. Biomed Chromatogr. 2008 May; 22(5):535-41. PMID: 18205140.
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    40. Lai CS, Mas RH, Nair NK, Majid MI, Mansor SM, Navaratnam V. Typhonium flagelliforme inhibits cancer cell growth in vitro and induces apoptosis: an evaluation by the bioactivity guided approach. J Ethnopharmacol. 2008 Jun 19; 118(1):14-20. PMID: 18436400.
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    41. Lai CS, Nair NK, Mansor SM, Olliaro PL, Navaratnam V. An analytical method with a single extraction procedure and two separate high performance liquid chromatographic systems for the determination of artesunate, dihydroartemisinin and mefloquine in human plasma for application in clinical pharmacological studies of the drug combination. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Oct 01; 857(2):308-14. PMID: 17719858.
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    42. Venkatesh G, Ramanathan S, Nair NK, Mansor SM, Sattar MA, Khan MA, Navaratnam V. Permeability of atenolol and propranolol in the presence of dimethyl sulfoxide in rat single-pass intestinal perfusion assay with liquid chromatography/UV detection. Biomed Chromatogr. 2007 May; 21(5):484-90. PMID: 17294505.
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    43. Venkatesh G, Ramanathan S, Mansor SM, Nair NK, Sattar MA, Croft SL, Navaratnam V. Development and validation of RP-HPLC-UV method for simultaneous determination of buparvaquone, atenolol, propranolol, quinidine and verapamil: a tool for the standardization of rat in situ intestinal permeability studies. J Pharm Biomed Anal. 2007 Mar 12; 43(4):1546-51. PMID: 17157469.
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    44. Simpson JA, Agbenyega T, Barnes KI, Di Perri G, Folb P, Gomes M, Krishna S, Krudsood S, Looareesuwan S, Mansor S, McIlleron H, Miller R, Molyneux M, Mwenechanya J, Navaratnam V, Nosten F, Olliaro P, Pang L, Ribeiro I, Tembo M, van Vugt M, Ward S, Weerasuriya K, Win K, White NJ. Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients. PLoS Med. 2006 Nov; 3(11):e444. PMID: 17132053; PMCID: PMC1664603.
    45. Ramanathan S, Karupiah S, Nair NK, Olliaro PL, Navaratnam V, Wernsdorfer WH, Mansor SM. A new and simple solid-phase extraction method for LC determination of pyronaridine in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25; 824(1-2):45-50. PMID: 16046285.
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    46. Olliaro PL, Nair NK, Sathasivam K, Mansor SM, Navaratnam V. Pharmacokinetics of artesunate after single oral administration to rats. BMC Pharmacol. 2001; 1:12. PMID: 11835690; PMCID: PMC65525.
    47. Saad B, Bee-Leng Y, Saleh MI, Rahman IA, Mansor SM. Polyvinyl chloride-based membranes for flow injection analysis of quinine in beverages. J AOAC Int. 2001 Jul-Aug; 84(4):1151-7. PMID: 11501917.
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    48. Krishna S, Planche T, Agbenyega T, Woodrow C, Agranoff D, Bedu-Addo G, Owusu-Ofori AK, Appiah JA, Ramanathan S, Mansor SM, Navaratnam V. Bioavailability and preliminary clinical efficacy of intrarectal artesunate in Ghanaian children with moderate malaria. Antimicrob Agents Chemother. 2001 Feb; 45(2):509-16. PMID: 11158748; PMCID: PMC90320.
    49. Navaratnam V, Mansor SM, Sit NW, Grace J, Li Q, Olliaro P. Pharmacokinetics of artemisinin-type compounds. Clin Pharmacokinet. 2000 Oct; 39(4):255-70. PMID: 11069212.
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    50. Navaratnam V, Mansor SM, Mordi MN, Akbar A, Abdullah MN. Comparative pharmacokinetic study of oral and rectal formulations of artesunic acid in healthy volunteers. Eur J Clin Pharmacol. 1998 Jul; 54(5):411-4. PMID: 9754985.
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    51. Selvamuniandy TS, Mohamed N, Mansor SM, Nair NK, Navaratnam V. Determination of 6,4'-bis-(2-imidazolinylhydrazone)-2-phenylimidazo[1,2-a]py ridine in plasma and whole blood by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1997 Oct 24; 700(1-2):209-13. PMID: 9390731.
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    52. Navaratnam V, Mordi MN, Mansor SM. Simultaneous determination of artesunic acid and dihydroartemisinin in blood plasma by high-performance liquid chromatography for application in clinical pharmacological studies. J Chromatogr B Biomed Sci Appl. 1997 Apr 25; 692(1):157-62. PMID: 9187395.
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    53. Mordi MN, Mansor SM, Navaratnam V, Wernsdorfer WH. Single dose pharmacokinetics of oral artemether in healthy Malaysian volunteers. Br J Clin Pharmacol. 1997 Apr; 43(4):363-5. PMID: 9146847; PMCID: PMC2042754.
    54. Mansor SM, Navaratnam V, Yahaya N, Nair NK, Wernsdorfer WH, Degen PH. Determination of a new antimalarial drug, benflumetol, in blood plasma by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1996 Jul 12; 682(2):321-5. PMID: 8844426.
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    55. Lokman Hakim S, Sharifah Roohi SW, Zurkurnai Y, Noor Rain A, Mansor SM, Palmer K, Navaratnam V, Mak JW. Plasmodium falciparum: increased proportion of severe resistance (RII and RIII) to chloroquine and high rate of resistance to sulfadoxine-pyrimethamine in Peninsular Malaysia after two decades. Trans R Soc Trop Med Hyg. 1996 May-Jun; 90(3):294-7. PMID: 8758083.
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    56. Navaratnam V, Mansor SM, Chin LK, Mordi MN, Asokan M, Nair NK. Determination of artemether and dihydroartemisinin in blood plasma by high-performance liquid chromatography for application in clinical pharmacological studies. J Chromatogr B Biomed Appl. 1995 Jul 21; 669(2):289-94. PMID: 7581905.
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    57. Ramanathan S, Nair NK, Mansor SM, Navaratnam V. Determination of the antifilarial drug UMF-078 and its metabolites UMF-060 and flubendazole in whole blood using high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1994 May 13; 655(2):269-73. PMID: 8081473.
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    58. Navaratnam V, Jamaludin A, Raman N, Mohamed M, Mansor SM. Determination of naltrexone dosage for narcotic agonist blockade in detoxified Asian addicts. Drug Alcohol Depend. 1994 Feb; 34(3):231-6. PMID: 8033761.
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    59. Ramanathan S, Nair NK, Mansor SM, Navaratnam V. Determination of a new antifilarial drug, UMF-058, and mebendazole in whole blood by high-performance liquid chromatography. J Chromatogr. 1993 Jun 02; 615(2):303-7. PMID: 8335708.
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    60. Mak JW, Navaratnam V, Grewel JS, Mansor SM, Ambu S. Treatment of subperiodic Brugia malayi infection with a single dose of ivermectin. Am J Trop Med Hyg. 1993 Apr; 48(4):591-6. PMID: 8480868.
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    61. Mansor SM, Ward SA, Edwards G. The effect of fever on quinine and quinidine disposition in the rat. J Pharm Pharmacol. 1991 Oct; 43(10):705-8. PMID: 1682445.
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    62. Mansor SM, Ward SA, Edwards G, Hoaksey PE, Breckenridge AM. The influence of alpha 1-acid glycoprotein on quinine and quinidine disposition in the rat isolated perfused liver preparation. J Pharm Pharmacol. 1991 Sep; 43(9):650-4. PMID: 1685525.
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    63. Mansor SM, Molyneux ME, Taylor TE, Ward SA, Wirima JJ, Edwards G. Effect of Plasmodium falciparum malaria infection on the plasma concentration of alpha 1-acid glycoprotein and the binding of quinine in Malawian children. Br J Clin Pharmacol. 1991 Sep; 32(3):317-21. PMID: 1777367; PMCID: PMC1368524.
    64. Molyneux ME, Taylor TE, Thomas CG, Mansor S, Wirima JJ. Efficacy of quinine for falciparum malaria according to previous chloroquine exposure. Lancet. 1991 Jun 08; 337(8754):1379-80. PMID: 1674766.
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    65. Mansor SM, Edwards G, Roberts PJ, Ward SA. The effect of malaria infection on paracetamol disposition in the rat. Biochem Pharmacol. 1991 Jun 01; 41(11):1707-11. PMID: 2043159.
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    66. Mansor SM, Ward SA, Edwards G. The effect of malaria infection on antipyrine metabolite formation in the rat. Biochem Pharmacol. 1991 Apr 15; 41(8):1264-6. PMID: 2009102.
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    67. Mansor SM, Taylor TE, McGrath CS, Edwards G, Ward SA, Wirima JJ, Molyneux ME. The safety and kinetics of intramuscular quinine in Malawian children with moderately severe falciparum malaria. Trans R Soc Trop Med Hyg. 1990 Jul-Aug; 84(4):482-7. PMID: 2091333.
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    68. Mansor SM, Ward SA, Edwards G, Hoaksey PE, Breckenridge AM. The effect of malaria infection on the disposition of quinine and quinidine in the rat isolated perfused liver preparation. J Pharm Pharmacol. 1990 Jun; 42(6):428-32. PMID: 1979624.
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    69. Mansor SM, Navaratnam V, Mohamad M, Hussein S, Kumar A, Jamaludin A, Wernsdorfer WH. Single dose kinetic study of the triple combination mefloquine/sulphadoxine/pyrimethamine (Fansimef) in healthy male volunteers. Br J Clin Pharmacol. 1989 Mar; 27(3):381-6. PMID: 2785812; PMCID: PMC1379839.
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