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Professor Kenneth Thomas Douglas

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lavrado J, Paulo A, Bichenkova E, Douglas KT, Moreira R. 1H NMR spectroscopic identification of protonable sites in cryptolepines with C-11 substituents containing two amino functionalities. Magn Reson Chem. 2012 Mar; 50(3):216-20. PMID: 22367848.
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    2. Lavrado J, Cabal GG, Prudêncio M, Mota MM, Gut J, Rosenthal PJ, Díaz C, Guedes RC, dos Santos DJ, Bichenkova E, Douglas KT, Moreira R, Paulo A. Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies. J Med Chem. 2011 Feb 10; 54(3):734-50. PMID: 21207937.
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    3. Bichenkova EV, Lang Z, Yu X, Rogert C, Douglas KT. DNA-mounted self-assembly: new approaches for genomic analysis and SNP detection. Biochim Biophys Acta. 2011 Jan; 1809(1):1-23. PMID: 21111076.
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    4. Chu ML, Lang Z, Chavas LM, Neres J, Fedorova OS, Tabernero L, Cherry M, Williams DH, Douglas KT, Eyers PA. Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes. Biochemistry. 2010 Mar 02; 49(8):1689-701. PMID: 20099905.
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    5. Mitchell FL, Frank F, Marks GE, Suzuki M, Douglas KT, Bryce RA. Molecular dynamics study of chemically engineered green fluorescent protein mutants: comparison of intramolecular fluorescence resonance energy transfer rate. Proteins. 2009 Apr; 75(1):28-39. PMID: 18767157.
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    6. Neres J, Brewer ML, Ratier L, Botti H, Buschiazzo A, Edwards PN, Mortenson PN, Charlton MH, Alzari PM, Frasch AC, Bryce RA, Douglas KT. Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):589-96. PMID: 19144516.
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    7. Walsh L, Gbaj A, Etchells LL, Douglas KT, Bichenkova EV. SNP detection for cytochrome P450 alleles by target-assembled tandem oligonucleotide systems based on exciplexes. J Biomol Struct Dyn. 2008 Jun; 25(6):629-40. PMID: 18399696.
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    8. Chu ML, Chavas LM, Douglas KT, Eyers PA, Tabernero L. Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125. J Biol Chem. 2008 Aug 01; 283(31):21495-500. PMID: 18480048.
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    9. Suzuki M, Husimi Y, Komatsu H, Suzuki K, Douglas KT. Quantum dot FRET biosensors that respond to pH, to proteolytic or nucleolytic cleavage, to DNA synthesis, or to a multiplexing combination. J Am Chem Soc. 2008 Apr 30; 130(17):5720-5. PMID: 18393422.
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    10. Neres J, Bryce RA, Douglas KT. Rational drug design in parasitology: trans-sialidase as a case study for Chagas disease. Drug Discov Today. 2008 Feb; 13(3-4):110-7. PMID: 18275908.
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    11. Mitchell FL, Marks GE, Bichenkova EV, Douglas KT, Bryce RA. Molecular probes: insights into design and analysis from computational and physical chemistry. Biochem Soc Trans. 2008 Feb; 36(Pt 1):46-50. PMID: 18208383.
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    12. Gbaj A, Walsh L, Rogert MC, Sardarian A, Bichenkova EV, Etchells LL, Whitcombe D, Douglas KT. Target-assembled exciplexes based on Scorpion oligonucleotides. Biosci Rep. 2008 Feb; 28(1):1-5. PMID: 18215149.
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    13. Walsh L, Gbaj A, Savage HE, Bacigalupo MC, Bichenkova EV, Douglas KT. Target-assembled ExciProbes: application to DNA detection at the level of PCR product and plasmid DNA. J Biomol Struct Dyn. 2007 Dec; 25(3):219-30. PMID: 17937484.
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    14. Valente C, Moreira R, Guedes RC, Iley J, Jaffar M, Douglas KT. The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors. Bioorg Med Chem. 2007 Aug 01; 15(15):5340-50. PMID: 17532221.
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    15. McNally VA, Rajabi M, Gbaj A, Stratford IJ, Edwards PN, Douglas KT, Bryce RA, Jaffar M, Freeman S. Design, synthesis and enzymatic evaluation of 6-bridged imidazolyluracil derivatives as inhibitors of human thymidine phosphorylase. J Pharm Pharmacol. 2007 Apr; 59(4):537-47. PMID: 17430637.
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    16. Bichenkova EV, Gbaj A, Walsh L, Savage HE, Rogert C, Sardarian AR, Etchells LL, Douglas KT. Detection of nucleic acids in situ: novel oligonucleotide analogues for target-assembled DNA-mounted exciplexes. Org Biomol Chem. 2007 Apr 07; 5(7):1039-51. PMID: 17377657.
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    17. Kuznetsov NA, Koval VV, Zharkov DO, Vorobjev YN, Nevinsky GA, Douglas KT, Fedorova OS. Pre-steady-state kinetic study of substrate specificity of Escherichia coli formamidopyrimidine--DNA glycosylase. Biochemistry. 2007 Jan 16; 46(2):424-35. PMID: 17209553.
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    18. Neres J, Bonnet P, Edwards PN, Kotian PL, Buschiazzo A, Alzari PM, Bryce RA, Douglas KT. Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase. Bioorg Med Chem. 2007 Mar 01; 15(5):2106-19. PMID: 17218104.
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    19. Kuznetsov NA, Koval VV, Nevinsky GA, Douglas KT, Zharkov DO, Fedorova OS. Kinetic conformational analysis of human 8-oxoguanine-DNA glycosylase. J Biol Chem. 2007 Jan 12; 282(2):1029-38. PMID: 17090545.
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    20. Neres J, Buschiazzo A, Alzari PM, Walsh L, Douglas KT. Continuous fluorimetric assay for high-throughput screening of inhibitors of trans-sialidase from Trypanosoma cruzi. Anal Biochem. 2006 Oct 15; 357(2):302-4. PMID: 16930524.
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    21. Zhang W, Steer CJ, Douglas KT, Rodrigues CM. Binding studies of bile acids using the native fluorescence of the tryptophan residue Of Bax protein. Biosci Rep. 2006 Jun; 26(3):245-50. PMID: 16850250.
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    22. Gbaj A, Edwards PN, Reigan P, Freeman S, Jaffar M, Douglas KT. Thymidine phosphorylase from Escherichia coli: tight-binding inhibitors as enzyme active-site titrants. J Enzyme Inhib Med Chem. 2006 Feb; 21(1):69-73. PMID: 16570508.
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    23. Parveen S, Khan MO, Austin SE, Croft SL, Yardley V, Rock P, Douglas KT. Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide. J Med Chem. 2005 Dec 15; 48(25):8087-97. PMID: 16335933.
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    24. Bichenkova EV, Sardarian AR, Wilton AN, Bonnet P, Bryce RA, Douglas KT. Exciplex fluorescence emission from simple organic intramolecular constructs in non-polar and highly polar media as model systems for DNA-assembled exciplex detectors. Org Biomol Chem. 2006 Jan 21; 4(2):367-78. PMID: 16391780.
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    25. Marks AH, Bhadra PK, McDowell DG, French DJ, Douglas KT, Bichenkova EV, Bryce RA. Molecular basis of action of HyBeacon fluorogenic probes: a spectroscopic and molecular dynamics study. J Biomol Struct Dyn. 2005 Aug; 23(1):49-62. PMID: 15918676.
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    26. Moreira R, Santana AB, Iley J, Neres J, Douglas KT, Horton PN, Hursthouse MB. Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase. J Med Chem. 2005 Jul 28; 48(15):4861-70. PMID: 16033266.
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    27. Hori Y, Rogert MC, Tanaka T, Kikuchi Y, Bichenkova EV, Wilton AN, Gbaj A, Douglas KT. Porphyrins and porphines bind strongly and specifically to tRNA, precursor tRNA and to M1 RNA and inhibit the ribonuclease P ribozyme reaction. Biochim Biophys Acta. 2005 Jul 25; 1730(1):47-55. PMID: 16005529.
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    28. Kuznetsov NA, Koval VV, Zharkov DO, Nevinsky GA, Douglas KT, Fedorova OS. Kinetics of substrate recognition and cleavage by human 8-oxoguanine-DNA glycosylase. Nucleic Acids Res. 2005; 33(12):3919-31. PMID: 16024742.
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    29. Bichenkova EV, Savage HE, Sardarian AR, Douglas KT. Target-assembled tandem oligonucleotide systems based on exciplexes for detecting DNA mismatches and single nucleotide polymorphisms. Biochem Biophys Res Commun. 2005 Jul 15; 332(4):956-64. PMID: 15913549.
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    30. Bichenkova EV, Yu X, Bhadra P, Heissigerova H, Pope SJ, Coe BJ, Faulkner S, Douglas KT. DNA mismatch detection by resonance energy transfer between ruthenium(II) and osmium(II) tris(2,2'-bipyridyl) chromophores. Inorg Chem. 2005 Jun 13; 44(12):4112-4. PMID: 15934730.
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    31. Suzuki M, Ito Y, Sakata I, Sakai T, Husimi Y, Douglas KT. Caspase-3 sensitive signaling in vivo in apoptotic HeLa cells by chemically engineered intramolecular fluorescence resonance energy transfer mutants of green fluorescent protein. Biochem Biophys Res Commun. 2005 May 06; 330(2):454-60. PMID: 15796904.
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    32. Bichenkova EV, Sardarian A, Savage HE, Rogert C, Douglas KT. An exciplex-based, target-assembled fluorescence system with inherently low background to probe for specific nucleic acid sequences. Assay Drug Dev Technol. 2005 Feb; 3(1):39-46. PMID: 15798394.
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    33. Reigan P, Edwards PN, Gbaj A, Cole C, Barry ST, Page KM, Ashton SE, Luke RW, Douglas KT, Stratford IJ, Jaffar M, Bryce RA, Freeman S. Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs. J Med Chem. 2005 Jan 27; 48(2):392-402. PMID: 15658853.
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    34. Reigan P, Gbaj A, Chinje E, Stratford IJ, Douglas KT, Freeman S. Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett. 2004 Nov 01; 14(21):5247-50. PMID: 15454205.
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    35. Beloglazova NG, Kirpota OO, Starostin KV, Ishchenko AA, Yamkovoy VI, Zharkov DO, Douglas KT, Nevinsky GA. Thermodynamic, kinetic and structural basis for recognition and repair of abasic sites in DNA by apurinic/apyrimidinic endonuclease from human placenta. Nucleic Acids Res. 2004; 32(17):5134-46. PMID: 15459284.
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    36. Suzuki M, Ito Y, Savage HE, Husimi Y, Douglas KT. Protease-sensitive signalling by chemically engineered intramolecular fluorescent resonance energy transfer mutants of green fluorescent protein. Biochim Biophys Acta. 2004 Sep 17; 1679(3):222-9. PMID: 15358514.
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    37. Pope SJ, Coe BJ, Faulkner S, Bichenkova EV, Yu X, Douglas KT. Self-assembly of heterobimetallic d-f hybrid complexes: sensitization of lanthanide luminescence by d-block metal-to-ligand charge-transfer excited states. J Am Chem Soc. 2004 Aug 11; 126(31):9490-1. PMID: 15291523.
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    38. Beloglazova NG, Fabani MM, Zenkova MA, Bichenkova EV, Polushin NN, Sil'nikov VV, Douglas KT, Vlassov VV. Sequence-specific artificial ribonucleases. I. Bis-imidazole-containing oligonucleotide conjugates prepared using precursor-based strategy. Nucleic Acids Res. 2004; 32(13):3887-97. PMID: 15273275.
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    39. Koval VV, Kuznetsov NA, Zharkov DO, Ishchenko AA, Douglas KT, Nevinsky GA, Fedorova OS. Pre-steady-state kinetics shows differences in processing of various DNA lesions by Escherichia coli formamidopyrimidine-DNA glycosylase. Nucleic Acids Res. 2004; 32(3):926-35. PMID: 14769949.
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    40. McNally VA, Gbaj A, Douglas KT, Stratford IJ, Jaffar M, Freeman S, Bryce RA. Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening. Bioorg Med Chem Lett. 2003 Nov 03; 13(21):3705-9. PMID: 14552762.
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    41. Zharkov DO, Ishchenko AA, Douglas KT, Nevinsky GA. Recognition of damaged DNA by Escherichia coli Fpg protein: insights from structural and kinetic data. Mutat Res. 2003 Oct 29; 531(1-2):141-56. PMID: 14637251.
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    42. Sardarian A, Douglas KT, Read M, Sims PF, Hyde JE, Chitnumsub P, Sirawaraporn R, Sirawaraporn W. Pyrimethamine analogs as strong inhibitors of double and quadruple mutants of dihydrofolate reductase in human malaria parasites. Org Biomol Chem. 2003 Mar 21; 1(6):960-4. PMID: 12929634.
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    43. Cole C, Reigan P, Gbaj A, Edwards PN, Douglas KT, Stratford IJ, Freeman S, Jaffar M. Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase. J Med Chem. 2003 Jan 16; 46(2):207-9. PMID: 12519058.
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    44. Ishchenko AA, Vasilenko NL, Sinitsina OI, Yamkovoy VI, Fedorova OS, Douglas KT, Nevinsky GA. Thermodynamic, kinetic, and structural basis for recognition and repair of 8-oxoguanine in DNA by Fpg protein from Escherichia coli. Biochemistry. 2002 Jun 18; 41(24):7540-8. PMID: 12056884.
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    45. Chan C, Yin H, McKie JH, Fairlamb AH, Douglas KT. Peptoid inhibition of trypanothione reductase as a potential antitrypanosomal and antileishmanial drug lead. Amino Acids. 2002 Jun; 22(4):297-308. PMID: 12107758.
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    46. Fauroux CM, Lee M, Cullis PM, Douglas KT, Gore MG, Freeman S. Stereochemistry at phosphorus of the reaction catalyzed by myo-inositol monophosphatase. J Med Chem. 2002 Mar 14; 45(6):1363-73. PMID: 11882005.
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    47. Fedorova OS, Nevinsky GA, Koval VV, Ishchenko AA, Vasilenko NL, Douglas KT. Stopped-flow kinetic studies of the interaction between Escherichia coli Fpg protein and DNA substrates. Biochemistry. 2002 Feb 05; 41(5):1520-8. PMID: 11814345.
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    48. Hori Y, Bichenkova EV, Wilton AN, Tanaka T, Douglas KT, Kikuchi Y. Porphyrins and porphines inhibit the ribonuclease P reaction in vitro. Nucleic Acids Res Suppl. 2002; (2):111-2. PMID: 12903130.
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    49. Breusegem SY, Sadat-Ebrahimi SE, Douglas KT, Bichenkova EV, Clegg RM, Loontiens FG. Experimental precedent for the need to involve the primary hydration layer of DNA in lead drug design. J Med Chem. 2001 Aug 02; 44(16):2503-6. PMID: 11472203.
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    50. Breusegem SY, Sadat-Ebrahimi SE, Douglas KT, Clegg RM, Loontiens FG. Increased stability and lifetime of the complex formed between DNA and meta-phenyl-substituted Hoechst dyes as studied by fluorescence titrations and stopped-flow kinetics. J Mol Biol. 2001 May 11; 308(4):649-63. PMID: 11350167.
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    51. Hori Y, Bichenkova EV, Wilton AN, El-Attug MN, Sadat-Ebrahimi S, Tanaka T, Kikuchi Y, Araki M, Sugiura Y, Douglas KT. Synthetic inhibitors of the processing of pretransfer RNA by the ribonuclease P ribozyme: enzyme inhibitors which act by binding to substrate. Biochemistry. 2001 Jan 23; 40(3):603-8. PMID: 11170376.
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    52. Bichenkova EV, Frau S, Fedorova OS, Douglas KT. Binding of a desmetallo-porphyrin conjugate of Hoechst 33258 to DNA. III. Strong bonding to single-strand oligonucleotides. Nucleosides Nucleotides Nucleic Acids. 2001 Jan-Feb; 20(1-2):157-68. PMID: 11303561.
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    53. McKie JH, Garforth J, Jaouhari R, Chan C, Yin H, Besheya T, Fairlamb AH, Douglas KT. Specific peptide inhibitors of trypanothione reductase with backbone structures unrelated to that of substrate: potential rational drug design lead frameworks. Amino Acids. 2001; 20(2):145-53. PMID: 11332449.
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    54. Frau S, Bichenkova EV, Morris GA, Douglas KT. Binding of a porphyrin conjugate of Hoechst 33258 to DNA. II. NMR spectroscopic studies detect multiple binding modes to a 12-mer nonself-complementary duplex DNA. Nucleosides Nucleotides Nucleic Acids. 2001 Jan-Feb; 20(1-2):145-56. PMID: 11303560.
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    55. Frau S, Bichenkova EV, Fedorova OS, Lokhov S, Douglas KT. Binding of a porphyrin conjugate of Hoechst 33258 to DNA. I. UV-visible and melting studies detect multiple binding modes to a 12-mer nonself-complementary duplex. Nucleosides Nucleotides Nucleic Acids. 2001 Jan-Feb; 20(1-2):131-43. PMID: 11303559.
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    56. Khan MO, Austin SE, Chan C, Yin H, Marks D, Vaghjiani SN, Kendrick H, Yardley V, Croft SL, Douglas KT. Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines. J Med Chem. 2000 Aug 10; 43(16):3148-56. PMID: 10956223.
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    57. Ishchenko AA, Koval VV, Fedorova OS, Douglas KT, Nevinsky GA. Structural requirements of double and single stranded DNA substrates and inhibitors, including a photoaffinity label, of Fpg protein from Escherichia coli. J Biomol Struct Dyn. 1999 Oct; 17(2):301-10. PMID: 10563580.
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    58. Bichenkova EV, Marks D, Dobrikov MI, Vlassov VV, Morris GA, Douglas KT. Refined high-field NMR solution structure of a binary-addressed pyrene/perfluoro-azide complementary DNA oligonucleotide system shows extensive distortion in the central nick region. J Biomol Struct Dyn. 1999 Oct; 17(2):193-211. PMID: 10563570.
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    59. Dobrikov MI, Bichenkova EV, Douglas KT, Gainutdinov TI, Vlassov VV. Structure of photoreactive binary system of oligonucleotide conjugates assembled on the target nucleotide sequence. J Biomol Struct Dyn. 1999 Oct; 17(2):213-21. PMID: 10563571.
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    60. Cole C, Marks DS, Jaffar M, Stratford IJ, Douglas KT, Freeman S. A similarity model for the human angiogenic factor, thymidine phosphorylase/platelet derived-endothelial cell growth factor. Anticancer Drug Des. 1999 Oct; 14(5):411-20. PMID: 10766296.
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    61. Austin SE, Khan MO, Douglas KT. Rational drug design using trypanothione reductase as a target for anti-trypanosomal and anti-leishmanial drug leads. Drug Des Discov. 1999 Jul; 16(1):5-23. PMID: 10466053.
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    62. Yuen CT, Garforth J, Besheya T, Jaouhari R, McKie JH, Fairlamb AH, Douglas KT. Synthesis and enzymology of modified N-benzyloxycarbonyl-L-cysteinylglycyl-3,3-dimethylaminopropylamide++ + disulphides as alternative substrates for trypanothione reductase from Trypanosoma cruzi: Part 3. Amino Acids. 1999; 17(2):175-83. PMID: 10524275.
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    63. Kennedy K, Baltas M, Douglas KT, Duran H, Embrey KJ, Giraudon JG, McKie JH, Grima-Pettenati J, Gorrichon L. Rational inhibitor design, synthesis and NMR spectroscopic study by transferred nuclear overhauser spectroscopy of novel inhibitors of cinnamyl alcohol dehydrogenase, a critical enzyme in lignification. J Enzyme Inhib. 1999; 14(3):217-37. PMID: 10445045.
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    64. Lüönd RM, McKie JH, Douglas KT, Dascombe MJ, Vale J. Inhibitors of glutathione reductase as potential antimalarial drugs. Kinetic cooperativity and effect of dimethyl sulphoxide on inhibition kinetics. J Enzyme Inhib. 1998 Aug; 13(5):327-45. PMID: 9793837.
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    65. McKie JH, Douglas KT, Chan C, Roser SA, Yates R, Read M, Hyde JE, Dascombe MJ, Yuthavong Y, Sirawaraporn W. Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria. J Med Chem. 1998 Apr 23; 41(9):1367-70. PMID: 9554869.
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    66. Chan C, Yin H, Garforth J, McKie JH, Jaouhari R, Speers P, Douglas KT, Rock PJ, Yardley V, Croft SL, Fairlamb AH. Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs. J Med Chem. 1998 Jan 15; 41(2):148-56. PMID: 9457238.
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    67. Bichenkova EV, Marks DS, Lokhov SG, Dobrikov MI, Vlassov VV, Douglas KT. Structural studies by high-field NMR spectroscopy of a binary-addressed complementary oligonucleotide system juxtaposing pyrene and perfluoro-azide units. J Biomol Struct Dyn. 1997 Oct; 15(2):307-20. PMID: 9399157.
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    68. Rafferty JA, Wibley JE, Speers P, Hickson I, Margison GP, Moody PC, Douglas KT. The potential role of glycine-160 of human O6-alkylguanine-DNA alkyltransferase in reaction with O6-benzylguanine as determined by site-directed mutagenesis and molecular modelling comparisons. Biochim Biophys Acta. 1997 Sep 26; 1342(1):90-102. PMID: 9366274.
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    69. Garforth J, Yin H, McKie JH, Douglas KT, Fairlamb AH. Rational design of selective ligands for trypanothione reductase from Trypanosoma cruzi. Structural effects on the inhibition by dibenzazepines based on imipramine. J Enzyme Inhib. 1997 Aug; 12(3):161-73. PMID: 9314113.
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    70. He YL, Murby S, Gifford L, Collett A, Warhurst G, Douglas KT, Rowland M, Ayrton J. Oral absorption of D-oligopeptides in rats via the paracellular route. Pharm Res. 1996 Nov; 13(11):1673-8. PMID: 8956333.
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    71. Wibley J, Deed R, Jasiok M, Douglas K, Norton J. A homology model of the Id-3 helix-loop-helix domain as a basis for structure-function predictions. Biochim Biophys Acta. 1996 May 23; 1294(2):138-46. PMID: 8645731.
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    72. Parkinson J, Sadat-Ebrahimi S, Wilton A, McKie JH, Andrews J, Douglas KT. Predictability of designing specific binding interactions for DNA minor groove ligands from NMR spectroscopy and molecular modeling: a copper(II)-activated DNA cleaver based on Hoechst 33258. Biochemistry. 1995 Dec 19; 34(50):16240-4. PMID: 8845347.
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    73. Jaouhari R, Besheya T, McKie JH, Douglas KT. Synthesis of symmetric disulfides as potential alternative substrates for trypanothione reductase and glutathione reductase: Part 1. Amino Acids. 1995 Dec; 9(4):327-42. PMID: 24178881.
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    74. Jaouhari R, Besheya T, McKie JH, Douglas KT. Synthesis of asymmetric disulfides as potential alternative substrates for trypanothione reductase and glutathione reductase: Part 2. Amino Acids. 1995 Dec; 9(4):343-51. PMID: 24178882.
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    75. Chan C, Yin H, Garforth J, McKie JH, Jaouhari RA, Douglas KT, Fairlamb AH, Croft SL. Inhibitors of trypanothione reductase as potential antitrypanosomal drugs. Biochem Soc Trans. 1995 Nov; 23(4):511S. PMID: 8654696.
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    76. Lauvergeat V, Kennedy K, Feuillet C, McKie JH, Gorrichon L, Baltas M, Boudet AM, Grima-Pettenati J, Douglas KT. Site-directed mutagenesis of a serine residue in cinnamyl alcohol dehydrogenase, a plant NADPH-dependent dehydrogenase, affects the specificity for the coenzyme. Biochemistry. 1995 Sep 26; 34(38):12426-34. PMID: 7547988.
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    77. Wibley JE, McKie JH, Embrey K, Marks DS, Douglas KT, Moore MH, Moody PC. A homology model of the three-dimensional structure of human O6-alkylguanine-DNA alkyltransferase based on the crystal structure of the C-terminal domain of the Ada protein from Escherichia coli. Anticancer Drug Des. 1995 Jan; 10(1):75-95. PMID: 7695814.
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    78. Garforth J, McKie JH, Jaouhari R, Benson TJ, Fairlamb AH, Douglas KT. Rational design of peptide-based inhibitors of trypanothione reductase as potential antitrypanosomal drugs. Amino Acids. 1994 Oct; 6(3):295-9. PMID: 24189737.
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    79. Douglas KT. Rational drug design in parasitology. Parasitol Today. 1994 Oct; 10(10):389-92. PMID: 15275544.
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    80. Cooke RJ, Björnestedt R, Douglas KT, McKie JH, King MD, Coles B, Ketterer B, Mannervik B. Photoaffinity labelling of the active site of the rat glutathione transferases 3-3 and 1-1 and human glutathione transferase A1-1. Biochem J. 1994 Sep 01; 302 ( Pt 2):383-90. PMID: 8092989.
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    81. Parkinson JA, Ebrahimi SE, McKie JH, Douglas KT. Molecular design of DNA-directed ligands with specific interactions: solution NMR studies of the interaction of a m-hydroxy analogue of Hoechst 33258 with d(CGCGAATTCGCG)2. Biochemistry. 1994 Jul 19; 33(28):8442-52. PMID: 7518248.
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    82. Embrey KJ, Mehta A, Carrington SJ, Jaouhari R, McKie JH, Douglas KT. Use of transferred nuclear-Overhauser-effect spectroscopy to measure the bound conformation of a disulphide-replaced analogue of glutathione disulphide as an inhibitor of yeast glutathione reductase. Eur J Biochem. 1994 Apr 15; 221(2):793-9. PMID: 8174559.
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    83. Rafferty JA, Tumelty J, Skorvaga M, Elder RH, Margison GP, Douglas KT. Site-directed mutagenesis of glutamic acid 172 to glutamine completely inactivated human O6-alkylguanine-DNA-alkyltransferase. Biochem Biophys Res Commun. 1994 Feb 28; 199(1):285-91. PMID: 8123025.
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    84. McKie JH, Douglas KT. A homology-derived structural model of the murine macrophage inflammatory protein, MIP-1 alpha. Drug Des Discov. 1994 Jan; 11(1):47-59. PMID: 8068819.
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    85. el-Waer AF, Smith K, McKie JH, Benson T, Fairlamb AH, Douglas KT. The glutamyl binding site of trypanothione reductase from Crithidia fasciculata: enzyme kinetic properties of gamma-glutamyl-modified substrate analogues. Biochim Biophys Acta. 1993 Nov 10; 1203(1):93-8. PMID: 8105896.
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    86. McKie JH, Jaouhari R, Douglas KT, Goffner D, Feuillet C, Grima-Pettenati J, Boudet AM, Baltas M, Gorrichon L. A molecular model for cinnamyl alcohol dehydrogenase, a plant aromatic alcohol dehydrogenase involved in lignification. Biochim Biophys Acta. 1993 Sep 03; 1202(1):61-9. PMID: 8373826.
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    87. Lüönd RM, McKie JH, Douglas KT. A direct link between LY83583, a selective repressor of cyclic GMP formation, and glutathione metabolism. Biochem Pharmacol. 1993 Jun 22; 45(12):2547-9. PMID: 8101080.
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    88. McKie JH, Douglas KT. Structural relationships between glyoxalase I and membrane transport proteins. Biochem Soc Trans. 1993 May; 21(2):540-4. PMID: 8359528.
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    89. el-Waer AF, Benson T, Douglas KT. Synthesis of substrate analogues for trypanothione reductase. Int J Pept Protein Res. 1993 Feb; 41(2):141-6. PMID: 8458687.
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    90. John DC, Douglas KT. Sequence-dependent reactivity of linear DNA to chemical cleavage by Cu(II):thiol combinations including cysteine or glutathione. Biochem J. 1993 Jan 15; 289 ( Pt 2):463-8. PMID: 8380996.
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    91. Benson TJ, McKie JH, Garforth J, Borges A, Fairlamb AH, Douglas KT. Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures. Biochem J. 1992 Aug 15; 286 ( Pt 1):9-11. PMID: 1355650.
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    92. Douglas KT, Ejim OS, Taylor K. Ferrocenopapain, an organometallic protein formed by site-specific inactivation of papain using chloroacetylferrocene. J Enzyme Inhib. 1992; 6(3):233-42. PMID: 1284960.
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    93. Santibanez-Koref M, Elder RH, Fan CY, Cawkwell L, McKie JH, Douglas KT, Margison GP, Rafferty JA. Isolation and partial characterization of murine O6-alkylguanine-DNA-alkyltransferase: comparative sequence and structural properties. Mol Carcinog. 1992; 5(2):161-9. PMID: 1554415.
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    94. el-Waer A, Douglas KT, Smith K, Fairlamb AH. Synthesis of N-benzyloxycarbonyl-L-cysteinylglycine 3-dimethylaminopropylamide disulfide: a cheap and convenient new assay for trypanothione reductase. Anal Biochem. 1991 Oct; 198(1):212-6. PMID: 1789428.
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    95. Reed CJ, Douglas KT. Chemical cleavage of plasmid DNA by glutathione in the presence of Cu(II) ions. The Cu(II)-thiol system for DNA strand scission. Biochem J. 1991 May 01; 275 ( Pt 3):601-8. PMID: 2039439.
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    96. McKie JH, Douglas KT. Evidence for gene duplication forming similar binding folds for NAD(P)H and FAD in pyridine nucleotide-dependent flavoenzymes. FEBS Lett. 1991 Feb 11; 279(1):5-8. PMID: 1995341.
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    97. Parkinson JA, Barber J, Douglas KT, Rosamond J, Sharples D. Minor-groove recognition of the self-complementary duplex d(CGCGAATTCGCG)2 by Hoechst 33258: a high-field NMR study. Biochemistry. 1990 Nov 06; 29(44):10181-90. PMID: 1703003.
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    98. John DC, Douglas KT. Apparent sequence preference in cleavage of linear B-DNA by the Cu(II):thiol system. Biochem Biophys Res Commun. 1989 Dec 29; 165(3):1235-42. PMID: 2610689.
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    99. Reed CJ, Douglas KT. Single-strand cleavage of DNA by Cu(II) and thiols: a powerful chemical DNA-cleaving system. Biochem Biophys Res Commun. 1989 Aug 15; 162(3):1111-7. PMID: 2504154.
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    100. Smith SL, Douglas KT. Stereoselective, strong inhibition of ribonucleotide reductase from E. coli by cisplatin. Biochem Biophys Res Commun. 1989 Jul 31; 162(2):715-23. PMID: 2667519.
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    101. John DC, Rosamund J, Douglas KT. Tight binding of a copper (II) phthalocyanine (cuprolinic blue) to DNA. Biochem Biophys Res Commun. 1989 Mar 31; 159(3):1256-62. PMID: 2930561.
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    102. Douglas KT. The thymidylate synthesis cycle and anticancer drugs. Med Res Rev. 1987 Oct-Dec; 7(4):441-75. PMID: 3309507.
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    103. Bunni MA, Baindur SR, Douglas KT, Drake AF. Organothallium(III) reagents for modification of biomacromolecules: irreversible labelling of phosphoglycerate kinase from rabbit muscle. Biochim Biophys Acta. 1987 Mar 19; 923(3):421-30. PMID: 3828383.
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    104. Baindur SR, Douglas KT. Organothallium(III) reagents for modification of biomacromolecules: interaction of thallium derivatives with transfer RNA. Biochim Biophys Acta. 1987 Jan 20; 923(1):66-73. PMID: 2432944.
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    105. Ahmet MT, Douglas KT, Silver J, Goddard AJ, Wilman DE. Iron and haem complexation studies of 2,3-dihydro-1H-imidazo(1,2-b)pyrazole (IMPY, NSC 51143), a tumour cell ribonucleotide reductase inhibitor. Anticancer Drug Des. 1986 Nov; 1(3):189-95. PMID: 3329911.
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    106. Al-Timari A, Douglas KT. Inhibition by glutathione derivatives of bovine liver glyoxalase II (hydroxyacylglutathione hydrolase) as a probe of the N- and S-sites for substrate binding. Biochim Biophys Acta. 1986 Mar 28; 870(2):219-25. PMID: 3955057.
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    107. Al-Timari A, Douglas KT. Inhibition of mammalian glyoxalase I (lactoylglutathione lyase) by N-acylated S-blocked glutathione derivatives as a probe for the role of the N-site of glutathione in glyoxalase I mechanism. Biochim Biophys Acta. 1986 Mar 07; 870(1):160-8. PMID: 3947646.
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    108. Douglas KT, Gohel DI, Nadvi IN, Quilter AJ, Seddon AP. Partial transition-state inhibitors of glyoxalase I from human erythrocytes, yeast and rat liver. Biochim Biophys Acta. 1985 May 20; 829(1):109-18. PMID: 3888271.
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    109. Douglas KT, Quilter AJ, Shinkai S, Ueda K. Trapping of reactive intermediates in enzymology. Exogenous flavin reduction during catalytic turnover of substrate by glyoxalase I. Biochim Biophys Acta. 1985 May 20; 829(1):119-26. PMID: 3888272.
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    110. Douglas KT, Sharif JG. pH Dependence of the inhibition of yeast glyoxalase I by porphyrins. Biochim Biophys Acta. 1983 Oct 28; 748(2):184-93. PMID: 6354270.
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    111. Ratwatte HA, Douglas KT. Photolabelling of dopamine-beta-hydroxylase by bleomycin. Biochem Biophys Res Commun. 1983 Apr 15; 112(1):273-8. PMID: 6188468.
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    112. Höög JO, Douglas KT, D'Silva C, Holmgren A. Photo-labelling of glutaredoxin from Escherichia coli. Biochem Biophys Res Commun. 1982 Aug 31; 107(4):1475-81. PMID: 6753845.
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    113. Nakagawa Y, Ghotb-Sharif J, Douglas KT. Carboxypeptidase Y from Saccharomyces cerevisiae. Conformational differences reflected in kinetic behaviour in water and deuterium oxide. Biochim Biophys Acta. 1982 Aug 23; 706(1):141-3. PMID: 6289903.
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    114. Höög JO, Holmgren A, D'Silva C, Douglas KT, Seddon AP. Glutathione derivatives as inhibitors of glutaredoxin and ribonucleotide reductase from Escherichia coli. FEBS Lett. 1982 Feb 08; 138(1):59-61. PMID: 7040106.
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    115. Seddon AP, Douglas KT. Photo-induced covalent labelling of malate dehydrogenase by quercetin. Biochem Biophys Res Commun. 1981 Sep 16; 102(1):15-21. PMID: 7306144.
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    116. Seddon AP, Bunni M, Douglas KT. Photoaffinity labelling by S-(p-azidophenacyl)-glutathione of glyoxalase II and glutathione S-transferase. Biochem Biophys Res Commun. 1980 Jul 16; 95(1):446-52. PMID: 7417267.
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    117. Guo JM, Chang C, Li NC, Douglas KT. Interactions of small ligands with Busycon canaliculatum and Limulus polyphemus hemocyanins as studied by ultraviolet spectrophotometry and 1H and 19F nuclear magnetic resonance. Biochemistry. 1978 Feb 07; 17(3):452-7. PMID: 23149.
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    118. Douglas KT, Nakagawa Y, Kaiser ET. Mechanistic studies of carboxypeptidase Y. Kinetic detection of an acyl-enzyme intermediate in trimethylacetate esterase action. J Am Chem Soc. 1976 Dec 08; 98(25):8231-6. PMID: 993522.
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