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Professor Kapil Mehta

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Agnihotri N, Mehta K. Transglutaminase-2: evolution from pedestrian protein to a promising therapeutic target. Amino Acids. 2017 03; 49(3):425-439. PMID: 27562794.
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    2. Mehta K, Gandhi V, Pathak S, Aggarwal BB, Grover RK. Multi-targeted approach to cancer treatment: an international translational cancer research symposium. Anticancer Res. 2014 Nov; 34(11):6791-5. PMID: 25368293.
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    3. Han AL, Kumar S, Fok JY, Tyagi AK, Mehta K. Tissue transglutaminase expression promotes castration-resistant phenotype and transcriptional repression of androgen receptor. Eur J Cancer. 2014 Jun; 50(9):1685-96. PMID: 24656569.
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    4. Kumar S, Donti TR, Agnihotri N, Mehta K. Transglutaminase 2 reprogramming of glucose metabolism in mammary epithelial cells via activation of inflammatory signaling pathways. Int J Cancer. 2014 Jun 15; 134(12):2798-807. PMID: 24477458.
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    5. Shin DH, Lee HJ, Min HY, Choi SP, Lee MS, Lee JW, Johnson FM, Mehta K, Lippman SM, Glisson BS, Lee HY. Combating resistance to anti-IGFR antibody by targeting the integrin ß3-Src pathway. J Natl Cancer Inst. 2013 Oct 16; 105(20):1558-70. PMID: 24092920.
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    6. Gandhi V, Mehta K, Pathak S, Aggarwal BB. Meeting report: leaders in translational cancer research meet in Udaipur, a historical town of India: an International Symposium onTranslational Cancer Research: Cancer Prevention. Udaipur, Rajasthan, India, december 16-19, 2011. Anticancer Res. 2013 Apr; 33(4):1777-81. PMID: 23564834.
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    7. Eker B, Meissner R, Bertsch A, Mehta K, Renaud P. Label-free recognition of drug resistance via impedimetric screening of breast cancer cells. PLoS One. 2013; 8(3):e57423. PMID: 23483910.
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    8. Agnihotri N, Kumar S, Mehta K. Tissue transglutaminase as a central mediator in inflammation-induced progression of breast cancer. Breast Cancer Res. 2013 Feb 25; 15(1):202. PMID: 23673317.
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    9. Kumar S, Mehta K. Tissue transglutaminase constitutively activates HIF-1a promoter and nuclear factor-?B via a non-canonical pathway. PLoS One. 2012; 7(11):e49321. PMID: 23185316.
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    10. Kumar A, Xu J, Sung B, Kumar S, Yu D, Aggarwal BB, Mehta K. Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells. Breast Cancer Res. 2012 Jan 06; 14(1):R4. PMID: 22225906.
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    11. Kumar S, Mehta K. Tissue transglutaminase, inflammation, and cancer: how intimate is the relationship? Amino Acids. 2013 Jan; 44(1):81-8. PMID: 22083892.
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    12. Kumar A, Gao H, Xu J, Reuben J, Yu D, Mehta K. Evidence that aberrant expression of tissue transglutaminase promotes stem cell characteristics in mammary epithelial cells. PLoS One. 2011; 6(6):e20701. PMID: 21687668.
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    13. Mehta K, Han A. Tissue Transglutaminase (TG2)-Induced Inflammation in Initiation, Progression, and Pathogenesis of Pancreatic Cancer. Cancers (Basel). 2011 Feb 25; 3(1):897-912. PMID: 24212645.
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    14. Kumar A, Xu J, Brady S, Gao H, Yu D, Reuben J, Mehta K. Tissue transglutaminase promotes drug resistance and invasion by inducing mesenchymal transition in mammary epithelial cells. PLoS One. 2010 Oct 12; 5(10):e13390. PMID: 20967228.
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    15. Mehta K, Kumar A, Kim HI. Transglutaminase 2: a multi-tasking protein in the complex circuitry of inflammation and cancer. Biochem Pharmacol. 2010 Dec 15; 80(12):1921-9. PMID: 20599779.
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    16. Gandhi V, Mehta K, Pathak S, Ravindran B, Mishra S, Aggarwal BB. City of temples discusses signaling templates in cancer cells. Third International Symposium on Translational Cancer Research: Cell Signaling & Cancer Therapy. Bhubaneswar, Orissa, India, December 18th through 21st, 2009. Anticancer Res. 2010 Jun; 30(6):2477-80. PMID: 20651411.
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    17. Akar U, Ozpolat B, Mehta K, Lopez-Berestein G, Zhang D, Ueno NT, Hortobagyi GN, Arun B. Targeting p70S6K prevented lung metastasis in a breast cancer xenograft model. Mol Cancer Ther. 2010 May; 9(5):1180-7. PMID: 20423989.
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    18. Chhabra A, Verma A, Mehta K. Tissue transglutaminase promotes or suppresses tumors depending on cell context. Anticancer Res. 2009 Jun; 29(6):1909-19. PMID: 19528447.
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    19. Wang D, Veena MS, Stevenson K, Tang C, Ho B, Suh JD, Duarte VM, Faull KF, Mehta K, Srivatsan ES, Wang MB. Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway. Clin Cancer Res. 2008 Oct 01; 14(19):6228-36. PMID: 18829502.
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    20. Hwang JY, Mangala LS, Fok JY, Lin YG, Merritt WM, Spannuth WA, Nick AM, Fiterman DJ, Vivas-Mejia PE, Deavers MT, Coleman RL, Lopez-Berestein G, Mehta K, Sood AK. Clinical and biological significance of tissue transglutaminase in ovarian carcinoma. Cancer Res. 2008 Jul 15; 68(14):5849-58. PMID: 18632639.
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    21. Mehta K. Biological and therapeutic significance of tissue transglutaminase in pancreatic cancer. Amino Acids. 2009 Apr; 36(4):709-16. PMID: 18594944.
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    22. Verma A, Guha S, Diagaradjane P, Kunnumakkara AB, Sanguino AM, Lopez-Berestein G, Sood AK, Aggarwal BB, Krishnan S, Gelovani JG, Mehta K. Therapeutic significance of elevated tissue transglutaminase expression in pancreatic cancer. Clin Cancer Res. 2008 Apr 15; 14(8):2476-83. PMID: 18413840.
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    23. Verma A, Guha S, Wang H, Fok JY, Koul D, Abbruzzese J, Mehta K. Tissue transglutaminase regulates focal adhesion kinase/AKT activation by modulating PTEN expression in pancreatic cancer cells. Clin Cancer Res. 2008 Apr 01; 14(7):1997-2005. PMID: 18381937.
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    24. Verma A, Mehta K. Transglutaminase-mediated activation of nuclear transcription factor-kappaB in cancer cells: a new therapeutic opportunity. Curr Cancer Drug Targets. 2007 Sep; 7(6):559-65. PMID: 17896921.
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    25. Fok JY, Mehta K. Tissue transglutaminase induces the release of apoptosis inducing factor and results in apoptotic death of pancreatic cancer cells. Apoptosis. 2007 Aug; 12(8):1455-63. PMID: 17440814.
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    26. Verma A, Mehta K. Tissue transglutaminase-mediated chemoresistance in cancer cells. Drug Resist Updat. 2007 Aug-Oct; 10(4-5):144-51. PMID: 17662645.
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    27. Ozpolat B, Akar U, Mehta K, Lopez-Berestein G. PKC delta and tissue transglutaminase are novel inhibitors of autophagy in pancreatic cancer cells. Autophagy. 2007 Sep-Oct; 3(5):480-3. PMID: 17507797.
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    28. Li L, Ahmed B, Mehta K, Kurzrock R. Liposomal curcumin with and without oxaliplatin: effects on cell growth, apoptosis, and angiogenesis in colorectal cancer. Mol Cancer Ther. 2007 Apr; 6(4):1276-82. PMID: 17431105.
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    29. Akar U, Ozpolat B, Mehta K, Fok J, Kondo Y, Lopez-Berestein G. Tissue transglutaminase inhibits autophagy in pancreatic cancer cells. Mol Cancer Res. 2007 Mar; 5(3):241-9. PMID: 17374730.
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    30. Verma A, Wang H, Manavathi B, Fok JY, Mann AP, Kumar R, Mehta K. Increased expression of tissue transglutaminase in pancreatic ductal adenocarcinoma and its implications in drug resistance and metastasis. Cancer Res. 2006 Nov 01; 66(21):10525-33. PMID: 17079475.
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    31. Mann AP, Verma A, Sethi G, Manavathi B, Wang H, Fok JY, Kunnumakkara AB, Kumar R, Aggarwal BB, Mehta K. Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway. Cancer Res. 2006 Sep 01; 66(17):8788-95. PMID: 16951195.
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    32. Gao Y, Camacho LH, Mehta K. Retinoic acid-induced CD38 antigen promotes leukemia cells attachment and interferon-gamma/interleukin-1beta-dependent apoptosis of endothelial cells: implications in the etiology of retinoic acid syndrome. Leuk Res. 2007 Apr; 31(4):455-63. PMID: 16920192.
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    33. Mehta K, Gandhi V, Aggarwal BB. All pathways to cancer apoptosis meeting in Thiruvananthapuram (India). Cell Death Differ. 2006 Dec; 13(12):2163-4. PMID: 16741526.
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    34. Fok JY, Ekmekcioglu S, Mehta K. Implications of tissue transglutaminase expression in malignant melanoma. Mol Cancer Ther. 2006 Jun; 5(6):1493-503. PMID: 16818508.
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    35. Mehta K, Fok JY, Mangala LS. Tissue transglutaminase: from biological glue to cell survival cues. Front Biosci. 2006 Jan 01; 11:173-85. PMID: 16146723.
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    36. Ozpolat B, Mehta K, Lopez-Berestein G. Regulation of a highly specific retinoic acid-4-hydroxylase (CYP26A1) enzyme and all-trans-retinoic acid metabolism in human intestinal, liver, endothelial, and acute promyelocytic leukemia cells. Leuk Lymphoma. 2005 Oct; 46(10):1497-506. PMID: 16194896.
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    37. Mangala LS, Arun B, Sahin AA, Mehta K. Tissue transglutaminase-induced alterations in extracellular matrix inhibit tumor invasion. Mol Cancer. 2005 Sep 09; 4:33. PMID: 16153302.
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    38. Padhye S, Afrasiabi Z, Sinn E, Fok J, Mehta K, Rath N. Antitumor metallothiosemicarbazonates: structure and antitumor activity of palladium complex of phenanthrenequinone thiosemicarbazone. Inorg Chem. 2005 Mar 07; 44(5):1154-6. PMID: 15732942.
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    39. Mehta K. Mammalian transglutaminases: a family portrait. Prog Exp Tumor Res. 2005; 38:1-18. PMID: 15746526.
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    40. Mangala LS, Mehta K. Tissue transglutaminase (TG2) in cancer biology. Prog Exp Tumor Res. 2005; 38:125-38. PMID: 15746533.
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    41. Rao RU, Chandrashekar R, Mehta K. Transglutaminases of lower organisms. Prog Exp Tumor Res. 2005; 38:209-22. PMID: 15746538.
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    42. Mehta K, Fok J, Miller FR, Koul D, Sahin AA. Prognostic significance of tissue transglutaminase in drug resistant and metastatic breast cancer. Clin Cancer Res. 2004 Dec 01; 10(23):8068-76. PMID: 15585642.
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    43. Chen JS, Konopleva M, Andreeff M, Multani AS, Pathak S, Mehta K. Drug-resistant breast carcinoma (MCF-7) cells are paradoxically sensitive to apoptosis. J Cell Physiol. 2004 Aug; 200(2):223-34. PMID: 15174092.
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    44. Ozpolat B, Tari AM, Mehta K, Lopez-Berestein G. Nuclear retinoid receptors are involved in N-(4-hydroxyphenyl) retinamide (Fenretinide)-induced gene expression and growth inhibition in HL-60 acute myeloid leukemia cells. Leuk Lymphoma. 2004 May; 45(5):979-85. PMID: 15291358.
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    45. Devarajan E, Mishra PK, Thirugnanam S, Mehta K, Chandrashekar R, Perumal K. Molecular characterization of a Brugia malayi transglutaminase. Parasitol Res. 2004 Jun; 93(2):145-50. PMID: 15127297.
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    46. Mehta K, Ocanas L, Malavasi F, Marks JW, Rosenblum MG. Retinoic acid-induced CD38 antigen as a target for immunotoxin-mediated killing of leukemia cells. Mol Cancer Ther. 2004 Mar; 3(3):345-52. PMID: 15026555.
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    47. Rao RU, Mehta K. Transglutaminases, thioredoxins and protein disulphide isomerase: diverse enzymes with a common goal of cross-linking proteins in lower organisms. Indian J Exp Biol. 2004 Mar; 42(3):235-43. PMID: 15233291.
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    48. Mehta K. Retinoids as regulators of gene transcription. J Biol Regul Homeost Agents. 2003 Jan-Mar; 17(1):1-12. PMID: 12757018.
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    49. Devarajan E, Sahin AA, Chen JS, Krishnamurthy RR, Aggarwal N, Brun AM, Sapino A, Zhang F, Sharma D, Yang XH, Tora AD, Mehta K. Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance. Oncogene. 2002 Dec 12; 21(57):8843-51. PMID: 12483536.
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    50. Mehta K, Devarajan E, Chen J, Multani A, Pathak S. Multidrug-resistant MCF-7 cells: an identity crisis? J Natl Cancer Inst. 2002 Nov 06; 94(21):1652-4; author reply 1654. PMID: 12419794.
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    51. Mehta K. Retinoic acid--a player that rules the game of life and death in neutrophils. Indian J Exp Biol. 2002 Aug; 40(8):874-81. PMID: 12597015.
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    52. Ozpolat B, Mehta K, Tari AM, Lopez-Berestein G. all-trans-Retinoic acid-induced expression and regulation of retinoic acid 4-hydroxylase (CYP26) in human promyelocytic leukemia. Am J Hematol. 2002 May; 70(1):39-47. PMID: 11994980.
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    53. Devarajan E, Chen J, Multani AS, Pathak S, Sahin AA, Mehta K. Human breast cancer MCF-7 cell line contains inherently drug-resistant subclones with distinct genotypic and phenotypic features. Int J Oncol. 2002 May; 20(5):913-20. PMID: 11956583.
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    54. Chandrashekar R, Devarajan E, Mehta K. Dirofilaria immitis: further characterization of the transglutaminase enzyme and its role in larval molting. Parasitol Res. 2002 Mar; 88(3):185-91. PMID: 11954902.
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    55. Chen JS, Agarwal N, Mehta K. Multidrug-resistant MCF-7 breast cancer cells contain deficient intracellular calcium pools. Breast Cancer Res Treat. 2002 Feb; 71(3):237-47. PMID: 12002342.
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    56. Chandrashekar R, Mehta K. Transglutaminase-catalyzed reactions in the growth, maturation and development of parasitic nematodes. Parasitol Today. 2000 Jan; 16(1):11-7. PMID: 10637581.
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    57. Chandrashekar R, Tsuji N, Morales T, Ozols V, Mehta K. An ERp60-like protein from the filarial parasite Dirofilaria immitis has both transglutaminase and protein disulfide isomerase activity. Proc Natl Acad Sci U S A. 1998 Jan 20; 95(2):531-6. PMID: 9435226.
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    58. Mehta K, Chandrashekar R, Rao UR. Transglutaminase-catalyzed incorporation of host proteins in Brugia malayi microfilariae. Mol Biochem Parasitol. 1996 Feb-Mar; 76(1-2):105-14. PMID: 8919999.
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