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Professor Eric Akum Achidi

TitleVice-Dean
InstitutionUniversity of Buea
DepartmentMedical Laboratory Science
AddressBuea
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    Personal Statement
    I am a practicing medical laboratory scientist, biomedical research scientist, and currently Project Coordinator of a European and Developing Countries Clinical Trials Partnership (EDCTP) funded regional nodes of excellence project title: “Central Africa Network for Tuberculosis, HIV/AIDS and Malaria towards developing clinical trial site in central Africa”. I participate in the design and coordination of the conduct of several ongoing collaborative studies aimed at providing baseline data for future intervention trials. My major areas of research include maternal-foetal interactions in malaria, understanding how immunity to malaria works, mechanisms involved in malaria pathogenesis and anti-malarial drug resistance monitoring amongst others. I have a strong track record of mentoring medical and paramedical students, postgraduate students (M.Sc and PhD students) and junior faculty. I frequently provide peer review services to some medical journals in the area of infectious diseases and I am member of the University of Buea Institutional Review Committee (created by me with finding from the EDCTP).
    I have vast experience in project management and have won 9 competitive externally funded research projects which have been successfully executed and delivered on schedule. My training in Immunology at the Department of Immunology Stockholm empowered me with cutting edge techniques in immunology. Furthermore, collaboration with the Welcome Trust centre for genetic research, University of Oxford in a 22 countries worldwide centered project aimed at understanding how immunity to malaria works exposed our group to high throughput genotyping techniques as over 500,000 SNPs were genotyped prospecting for susceptibility and protective SNPs. These exposures endow on our group the capacity to participate in immunological and genotyping studies. In a previous study we recruited children of different clinical (mild, moderate and severe malaria) and non clinical (malaria infection with no symptoms and apparently healthy) children in a malaria endemic area, we performed basic haematological, biochemical and immunological analyses. DNA extracted was genotyped for SNPs known to demonstrate protection or susceptibility and prospected for other SNPs that could be associated with protection or susceptibility. New candidate SNPs were identified that need to be validated in controlled clinical studies. In another published study involving samples from 6 other countries funded by the International Atomic Energy Agency (IAEA), clinical samples were genotyped from patients that responded to antimalarial therapy and those that demonstrated resistance. The objective was to identify SNPs that could be associated with antimalarial drug resistance. Results demonstrated some SNPs that were predominant in patients who experienced drug resistance thus providing leads for the development of methods that exploit genes in predicting drug resistance.

    Our group has the experience to contribute towards the successful implementation of the proposed research project.

    B. Positions and Honors Positions
    1995-1998 Assistant Lecturer, Faculty of Health Sciences, University of Buea, Cameroon
    1998-2007 Senior Lecturer, Faculty of Health Sciences, University of Buea, Cameroon

    1999-2012 Vice-Dean i/c Studies and Student’s Affairs, Faculty of Health Sciences, University of Buea, Cameroon

    2000-2005 Head of Department, Department of Medical Laboratory Science, Faculty of Health Sciences, University of Buea, Cameroon
    2004-2005 Acting Dean, Faculty of Health Sciences, University of Buea, Cameroon
    2006-2010 Chair, Malaria Immunology and Pathogenesis Network (MIMPAC);
    consortium of African institutions engaged in studies on the Immunology and Pathogenesis of malaria
    2008-2013 Associate Professor, Faculty of Health Sciences, University of Buea Cameroon.
    2011-2012 Acting Dean, Faculty of Health Sciences, University of Buea, Cameroon.
    2012-Date Vice-Dean i/c Studies and Student’s Affairs, Faculty of Science, University of Buea, Cameroon

    Other Experience and Professional Memberships
    1997: Member of the expert committee on harmonisation of medical degree programmes of State Universities in Cameroon, Yaounde.
    1998: Member of the expert committee on the development of curriculum for Higher National Diploma (HND) for the Ministry of Higher Education, Cameroon
    2003-2009: Member of the Scientific and Coordinating Committee (SCC) of the African Malaria Network Trust (AMANET).
    2005: Member of the AfroGuide network, developing guidelines for health research in Africa. Coordinated by the United Nations Economic Commission for Africa, Addis Ababa, Ethiopia.
    2009-2014: Member of the Governing Board of the Malaria Genomic and Epidemiology Network (MalariaGEN), funded by the Grand Challenges in Health Programme by the Bill and Melinda Gates Foundation through the Foundations of the National Institutes of Health USA and in partnership with the Wellcome Trust, UK
    2010-2015: Full member, European Virtual Institute for Malaria Research (EVIMalaR), European Union funded network of excellence involving 37 European institutions and five African institutions collaborating in innovative malaria research
    2015-date: Founding member of the African Malaria Research Network (AfriMalaR)

    Honors

    1991 Cameroon Government Scholarship to read PhD degree at the University of Ibadan, Nigeria
    1997 WHO postdoctoral scholarship for training in advanced Immunological methods at the University of Stockholm, Sweden.
    2007 Best African Malaria Researcher award, Awarded by the Multilateral Initiative on Malaria/Tropical Disease Research (MIM/TDR) World Health Organization
    2007 Best clinical research article from a developing country award titled: “Malaria parasitaemia and systemic cytokine bias in pregnancy; International Journal of Gynecology & Obstetrics; 2007, 97:15-20”. A John J. Sciarra International Journal of Gynecology & Obstetrics paper award, awarded by the International Federation of Gynecologist and Obstetricians (FIGO).

    C. Contributions to Science/Research Interests
    My contributions involve the use of epidemiological and immunological tools in dissecting the immune natural responses that occur at the maternal-foetal interphase and understanding how immunity to malaria works in view of contributing valuable information towards malaria vaccine development.
    Overall, my research interest is on malaria which is one of the poverty related diseases that is endemic to Africa south of the Sahara. It also features as one of the targeted diseases in the millennium development goals. Firstly my research interest has been focused on understanding the acquisition of natural immune responses to malaria in residents of endemic areas using malaria vaccine candidates and investigating the impact of co-infections especially helminthes on disease outcomes.

    Secondly I have been interested in studying the impact of malaria in pregnancy on the mother and the foetus and in longitudinal cohort studies investigating the effect of foetal development in a malaria parasitised environment on level of transplacentally acquired immunity and its immune response to malaria during infancy. Furthermore I was interested in demonstrating whether exposure of the foetus to malaria parasites during pregnancy may render it more susceptible to malaria attacks during the first months of life.

    Thirdly I have been interested in understanding the mechanisms that explains why children who are equally exposed to natural malaria infection respond differently in terms of disease outcome. Particularly I have investigated the role played by specific antibodies, cytokines and some gene polymorphisms in the pathogenesis of severe malaria defined as severe malaria anaemia and cerebral malaria.

    Fourthly, I developed interest in determining the efficacy of both first line and commonly prescribed antimalarial drugs in our community. Studies have focused on determining the safety and efficacy of quinine sulphate and Artesunate/Amodiaquine therapy in our community.

    Recently, I have developed interest in health research ethics especially with identifying those areas of the international guidelines on health research where there are needs to adapt these in the African context. Lastly my focus in the years ahead will be to develop capacity for health research particularly with regards to clinical trials of new interventions for malaria.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Anchang-Kimbi JK, Nkweti VN, Ntonifor HN, Apinjoh TO, Tata RB, Chi HF, Achidi EA. Plasmodium falciparum parasitaemia and malaria among pregnant women at first clinic visit in the mount Cameroon Area. BMC Infect Dis. 2015 Oct 22; 15:439. PMID: 26494140; PMCID: PMC4619095.
    2. Apinjoh TO, Tata RB, Anchang-Kimbi JK, Chi HF, Fon EM, Mugri RN, Tangoh DA, Nyingchu RV, Ghogomu SM, Nkuo-Akenji T, Achidi EA. Plasmodium falciparum merozoite surface protein 1 block 2 gene polymorphism in field isolates along the slope of mount Cameroon: a cross - sectional study. BMC Infect Dis. 2015 Aug 05; 15:309. PMID: 26242307; PMCID: PMC4526171.
    3. Edie GE, Obinchemti TE, Tamufor EN, Njie MM, Njamen TN, Achidi EA. Perceptions of antenatal care services by pregnant women attending government health centres in the Buea Health District, Cameroon: a cross sectional study. Pan Afr Med J. 2015; 21:45. PMID: 26405481; PMCID: PMC4564405.
    4. Apinjoh TO, Anchang-Kimbi JK, Mugri RN, Njua-Yafi C, Tata RB, Chi HF, Tangoh DA, Loh BT, Achidi EA. Determinants of infant susceptibility to malaria during the first year of life in South Western cameroon. Open Forum Infect Dis. 2015 Jan; 2(1):ofv012. PMID: 26034763; PMCID: PMC4438893.
    5. Apinjoh TO, Anchang-Kimbi JK, Mugri RN, Tangoh DA, Nyingchu RV, Chi HF, Tata RB, Njumkeng C, Njua-Yafi C, Achidi EA. The effect of Insecticide Treated Nets (ITNs) on Plasmodium falciparum infection in rural and semi-urban communities in the south west region of Cameroon. PLoS One. 2015; 10(2):e0116300. PMID: 25714837; PMCID: PMC4340618.
    6. Ndze VN, Esona MD, Achidi EA, Gonsu KH, Dóró R, Marton S, Farkas S, Ngeng MB, Ngu AF, Obama-Abena MT, Bányai K. Full genome characterization of human Rotavirus A strains isolated in Cameroon, 2010-2011: diverse combinations of the G and P genes and lack of reassortment of the backbone genes. Infect Genet Evol. 2014 Dec; 28:537-60. PMID: 25460824.
      View in: PubMed
    7. Apinjoh TO, Anchang-Kimbi JK, Njua-Yafi C, Ngwai AN, Mugri RN, Clark TG, Rockett KA, Kwiatkowski DP, Achidi EA. Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case-control study. Malar J. 2014 Jun 16; 13:236. PMID: 24934404; PMCID: PMC4077225.
    8. Anchang-Kimbi JK, Achidi EA, Apinjoh TO, Mugri RN, Chi HF, Tata RB, Nkegoum B, Mendimi JM, Sverremark-Ekström E, Troye-Blomberg M. Antenatal care visit attendance, intermittent preventive treatment during pregnancy (IPTp) and malaria parasitaemia at delivery. Malar J. 2014 Apr 30; 13:162. PMID: 24779545; PMCID: PMC4019363.
    9. Ali IM, Netongo PM, Atogho-Tiedeu B, Ngongang EO, Ajua A, Achidi EA, Mbacham WF. Amodiaquine-Artesunate versus Artemether-Lumefantrine against Uncomplicated Malaria in Children Less Than 14 Years in Ngaoundere, North Cameroon: Efficacy, Safety, and Baseline Drug Resistant Mutations in pfcrt, pfmdr1, and pfdhfr Genes. Malar Res Treat. 2013; 2013:234683. PMID: 24455414; PMCID: PMC3876914.
    10. Apinjoh TO, Anchang-Kimbi JK, Njua-Yafi C, Mugri RN, Ngwai AN, Rockett KA, Mbunwe E, Besingi RN, Clark TG, Kwiatkowski DP, Achidi EA. Association of cytokine and Toll-like receptor gene polymorphisms with severe malaria in three regions of Cameroon. PLoS One. 2013; 8(11):e81071. PMID: 24312262; PMCID: PMC3842328.
    11. Ndze VN, Papp H, Achidi EA, Gonsu KH, László B, Farkas S, Kisfali P, Melegh B, Esona MD, Bowen MD, Bányai K, Gentsch JR, Odama AM. One year survey of human rotavirus strains suggests the emergence of genotype G12 in Cameroon. J Med Virol. 2013 Aug; 85(8):1485-90. PMID: 23765785.
      View in: PubMed
    12. Ndze VN, Achidi EA, Papp H, Kovács E, Farkas S, Adiogo D, Kisfali P, Ngeng MB, Abena MT, Martella V, Esona MD, Bányai K. Shared G12 VP7 gene among human and bovine rotaviruses detected in Cameroonian villages. Acta Microbiol Immunol Hung. 2013 Mar; 60(1):21-8. PMID: 23529296.
      View in: PubMed
    13. Tchinda GG, Atashili J, Achidi EA, Kamga HL, Njunda AL, Ndumbe PM. Impact of malaria on hematological parameters in people living with HIV/AIDS attending the Laquintinie Hospital in Douala, Cameroon. PLoS One. 2012; 7(7):e40553. PMID: 22802967; PMCID: PMC3393653.
    14. Achidi EA, Apinjoh TO, Anchang-Kimbi JK, Mugri RN, Ngwai AN, Yafi CN. Severe and uncomplicated falciparum malaria in children from three regions and three ethnic groups in Cameroon: prospective study. Malar J. 2012 Jun 24; 11:215. PMID: 22727184; PMCID: PMC3445823.
    15. Diakite M, Achidi EA, Achonduh O, Craik R, Djimde AA, Evehe MS, Green A, Hubbart C, Ibrahim M, Jeffreys A, Khan BK, Kimani F, Kwiatkowski DP, Mbacham WF, Jezan SO, Ouedraogo JB, Rockett K, Rowlands K, Tagelsir N, Tekete MM, Zongo I, Ranford-Cartwright LC. Host candidate gene polymorphisms and clearance of drug-resistant Plasmodium falciparum parasites. Malar J. 2011 Aug 25; 10:250. PMID: 21867552; PMCID: PMC3177816.
    16. Awah N, Balogun H, Achidi E, Mariuba LA, Nogueira PA, Orlandi P, Troye-Blomberg M, Gysin J, Berzins K. Antibodies to the Plasmodium falciparum rhoptry protein RAP-2/RSP-2 in relation to anaemia in Cameroonian children. Parasite Immunol. 2011 Feb; 33(2):104-15. PMID: 21226723.
      View in: PubMed
    17. Takem EN, Achidi EA, Ndumbe PM. An update of malaria infection and anaemia in adults in Buea, Cameroon. BMC Res Notes. 2010 Apr 30; 3:121. PMID: 20433718; PMCID: PMC2885408.
    18. Takem EN, Achidi EA, Ndumbe PM. Use of intermittent preventive treatment for malaria by pregnant women in Buea, Cameroon. Acta Trop. 2009 Oct; 112(1):54-8. PMID: 19539589.
      View in: PubMed
    19. Anchang-Kimbi JK, Achidi EA, Nkegoum B, Sverremark-Ekström E, Troye-Blomberg M. Diagnostic comparison of malaria infection in peripheral blood, placental blood and placental biopsies in Cameroonian parturient women. Malar J. 2009 Jun 08; 8:126. PMID: 19505312; PMCID: PMC2702348.
    20. Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P, Clark TG, Kivinen K, Bojang KA, Conway DJ, Pinder M, Sirugo G, Sisay-Joof F, Usen S, Auburn S, Bumpstead SJ, Campino S, Coffey A, Dunham A, Fry AE, Green A, Gwilliam R, Hunt SE, Inouye M, Jeffreys AE, Mendy A, Palotie A, Potter S, Ragoussis J, Rogers J, Rowlands K, Somaskantharajah E, Whittaker P, Widden C, Donnelly P, Howie B, Marchini J, Morris A, SanJoaquin M, Achidi EA, Agbenyega T, Allen A, Amodu O, Corran P, Djimde A, Dolo A, Doumbo OK, Drakeley C, Dunstan S, Evans J, Farrar J, Fernando D, Hien TT, Horstmann RD, Ibrahim M, Karunaweera N, Kokwaro G, Koram KA, Lemnge M, Makani J, Marsh K, Michon P, Modiano D, Molyneux ME, Mueller I, Parker M, Peshu N, Plowe CV, Puijalon O, Reeder J, Reyburn H, Riley EM, Sakuntabhai A, Singhasivanon P, Sirima S, Tall A, Taylor TE, Thera M, Troye-Blomberg M, Williams TN, Wilson M, Kwiatkowski DP. Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet. 2009 Jun; 41(6):657-65. PMID: 19465909; PMCID: PMC2889040.
    21. Achidi EA, Apinjoh TO, Mbunwe E, Besingi R, Yafi C, Wenjighe Awah N, Ajua A, Anchang JK. Febrile status, malarial parasitaemia and gastro-intestinal helminthiases in schoolchildren resident at different altitudes, in south-western Cameroon. Ann Trop Med Parasitol. 2008 Mar; 102(2):103-18. PMID: 18318932.
      View in: PubMed
    22. Achidi EA, Apinjoh TO, Titanji VP. Malaria parasitemia and systemic cytokine bias in pregnancy. Int J Gynaecol Obstet. 2007 Apr; 97(1):15-20. PMID: 17331514.
      View in: PubMed
    23. Akum AE, Kuoh AJ, Minang JT, Achimbom BM, Ahmadou MJ, Troye-Blomberg M. The effect of maternal, umbilical cord and placental malaria parasitaemia on the birthweight of newborns from South-western Cameroon. Acta Paediatr. 2005 Jul; 94(7):917-23. PMID: 16188815.
      View in: PubMed
    24. Achidi EA, Anchang JK, Minang JT, Ahmadou MJ, Troye-Blomberg M. Studies on Plasmodium falciparum isotypic antibodies and numbers of IL-4 and IFN-gamma secreting cells in paired maternal cord blood from South West Cameroon. Int J Infect Dis. 2005 May; 9(3):159-69. PMID: 15840457.
      View in: PubMed
    25. Akum AE, Minang JT, Kuoh AJ, Ahmadou MJ, Troye-Blomberg M. Plasmodium falciparum inhibitory capacities of paired maternal-cord sera from south-west province, Cameroon. J Trop Pediatr. 2005 Jun; 51(3):182-90. PMID: 15855302.
      View in: PubMed
    26. Achidi EA, Kuoh AJ, Minang JT, Ngum B, Achimbom BM, Motaze SC, Ahmadou MJ, Troye-Blomberg M. Malaria infection in pregnancy and its effects on haemoglobin levels in women from a malaria endemic area of Fako Division, South West Province, Cameroon. J Obstet Gynaecol. 2005 Apr; 25(3):235-40. PMID: 16147724.
      View in: PubMed
    27. Achidi EA, Ajua A, Kimbi HK, Sinju CM. In vivo efficacy study of quinine sulphate in the treatment of uncomplicated P. falciparum malaria in patients from Southwestern Cameroon. East Afr Med J. 2005 Apr; 82(4):181-5. PMID: 16122085.
      View in: PubMed
    28. Minang JT, Gyan BA, Anchang JK, Troye-Blomberg M, Perlmann H, Achidi EA. Haptoglobin phenotypes and malaria infection in pregnant women at delivery in western Cameroon. Acta Trop. 2004 Mar; 90(1):107-14. PMID: 14739029.
      View in: PubMed
    29. Nkuo Akenji TK, Ajame EA, Achidi EA. An investigation of symptomatic malaria parasitaemia and anaemia in nursery and primary school children in Buea District Cameroon. Cent Afr J Med. 2002 Jan-Feb; 48(1-2):1-4. PMID: 12808780.
      View in: PubMed
    30. Achidi EA, Salimonu LS. Malaria parasitaemia and immunoglobulin levels in paired maternal-cord sera from south western Nigeria. Afr J Med Med Sci. 1997 Sep-Dec; 26(3-4):167-70. PMID: 10456162.
      View in: PubMed
    31. Achidi EA, Salimonu LS, Perlmann H, Perlmann P, Berzins K, Williams AI. Lack of association between levels of transplacentally acquired Plasmodium falciparum-specific antibodies and age of onset of clinical malaria in infants in a malaria endemic area of Nigeria. Acta Trop. 1996 Aug; 61(4):315-26. PMID: 8910656.
      View in: PubMed
    32. Achidi EA, Salimonu LS, Asuzu MC, Berzins K, Walker O. Studies on Plasmodium falciparum parasitemia and development of anemia in Nigerian infants during their first year of life. Am J Trop Med Hyg. 1996 Aug; 55(2):138-43. PMID: 8780450.
      View in: PubMed
    33. Achidi EA, Perlmann H, Berzins K. Asymptomatic malaria parasitaemia and seroreactivities to Plasmodium falciparum antigens in blood donors from Ibadan, south-western Nigeria. Ann Trop Med Parasitol. 1995 Dec; 89(6):601-10. PMID: 8745935.
      View in: PubMed
    34. Achidi EA, Perlmann H, Salimonu LS, Asuzu MC, Perlmann P, Berzins K. Antibodies to Pf155/RESA and circumsporozoite protein of Plasmodium falciparum in paired maternal-cord sera from Nigeria. Parasite Immunol. 1995 Oct; 17(10):535-40. PMID: 8587791.
      View in: PubMed
    35. Achidi EA, Perlmann H, Salimonu LS, Perlmann P, Walker O, Asuzu MC. A longitudinal study of seroreactivities to Plasmodium falciparum antigens in Nigerian infants during their first year of life. Acta Trop. 1995 May; 59(2):173-83. PMID: 7676908.
      View in: PubMed
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