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Professor Lourival Possani

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Riaño-Umbarila L, Rodríguez-Rodríguez ER, Santibañez-López CE, Güereca L, Uribe-Romero SJ, Gómez-Ramírez IV, Cárcamo-Noriega EN, Possani LD, Becerril B. Updating knowledge on new medically important scorpion species in Mexico. Toxicon. 2017 Nov; 138:130-137. PMID: 28847707.
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    2. Olamendi-Portugal T, Csoti A, Jimenez-Vargas JM, Gomez-Lagunas F, Panyi G, Possani LD. Pi5 and Pi6, two undescribed peptides from the venom of the scorpion Pandinus imperator and their effects on K(+)-channels. Toxicon. 2017 Jul; 133:136-144. PMID: 28502745.
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    3. Santibáñez-López CE, Cid-Uribe JI, Zamudio FZ, Batista CVF, Ortiz E, Possani LD. Venom gland transcriptomic and venom proteomic analyses of the scorpion Megacormus gertschi Díaz-Najera, 1966 (Scorpiones: Euscorpiidae: Megacorminae). Toxicon. 2017 Jul; 133:95-109. PMID: 28478058.
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    4. Jiménez-Vargas JM, Quintero-Hernández V, Gonzalez-Morales L, Ortiz E, Possani LD. Corrigendum to "Design and expression of recombinant toxins from Mexican scorpions of the genus Centruroides for production of antivenoms" [Toxicon 128 (2017) 5-14]. Toxicon. 2017 May; 130:126. PMID: 28284065.
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    5. Restano-Cassulini R, Garcia W, Paniagua-Solís JF, Possani LD. Antivenom Evaluation by Electrophysiological Analysis. Toxins (Basel). 2017 Feb 23; 9(3). PMID: 28241514.
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    6. Jiménez-Vargas JM, Quintero-Hernández V, González-Morales L, Ortiz E, Possani LD. Design and expression of recombinant toxins from Mexican scorpions of the genus Centruroides for production of antivenoms. Toxicon. 2017 Mar 15; 128:5-14. PMID: 28126552.
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    7. Jáuregui-Zúñiga D, Pedraza-Escalona M, Espino-Solís GP, Quintero-Hernández V, Olvera-Rodríguez A, Díaz-Salinas MA, López S, Possani LD. Targeting antigens to Dec-205 on dendritic cells induces a higher immune response in chickens: Hemagglutinin of avian influenza virus example. Res Vet Sci. 2017 Apr; 111:55-62. PMID: 27987414.
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    8. Santibáñez-López CE, Cid-Uribe JI, Batista CV, Ortiz E, Possani LD. Venom Gland Transcriptomic and Proteomic Analyses of the Enigmatic Scorpion Superstitionia donensis (Scorpiones: Superstitioniidae), with Insights on the Evolution of Its Venom Components. Toxins (Basel). 2016 Dec 09; 8(12). PMID: 27941686.
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    9. Cid Uribe JI, Jiménez Vargas JM, Ferreira Batista CV, Zamudio Zuñiga F, Possani LD. Comparative proteomic analysis of female and male venoms from the Mexican scorpion Centruroides limpidus: Novel components found. Toxicon. 2017 Jan; 125:91-98. PMID: 27889600.
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    10. Olamendi-Portugal T, Restano-Cassulini R, Riaño-Umbarila L, Becerril B, Possani LD. Functional and immuno-reactive characterization of a previously undescribed peptide from the venom of the scorpion Centruroides limpidus. Peptides. 2017 Jan; 87:34-40. PMID: 27871874.
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    11. Olamendi-Portugal T, Bartok A, Zamudio-Zuñiga F, Balajthy A, Becerril B, Panyi G, Possani LD. Isolation, chemical and functional characterization of several new K(+)-channel blocking peptides from the venom of the scorpion Centruroides tecomanus. Toxicon. 2016 Jun 01; 115:1-12. PMID: 26921461.
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    12. Santibáñez-López CE, Francke OF, Ureta C, Possani LD. Scorpions from Mexico: From Species Diversity to Venom Complexity. Toxins (Basel). 2015 Dec 24; 8(1). PMID: 26712787; PMCID: PMC4728524.
    13. Ramírez-Carreto S, Jiménez-Vargas JM, Rivas-Santiago B, Corzo G, Possani LD, Becerril B, Ortiz E. Peptides from the scorpion Vaejovis punctatus with broad antimicrobial activity. Peptides. 2015 Nov; 73:51-9. PMID: 26352292.
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    14. Santibáñez-López CE, Possani LD. Overview of the Knottin scorpion toxin-like peptides in scorpion venoms: Insights on their classification and evolution. Toxicon. 2015 Dec 01; 107(Pt B):317-26. PMID: 26187850.
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    15. Rodríguez-Ravelo R, Batista CV, Coronas FI, Zamudio FZ, Hernández-Orihuela L, Espinosa-López G, Ruiz-Urquiola A, Possani LD. Comparative proteomic analysis of male and female venoms from the Cuban scorpion Rhopalurus junceus. Toxicon. 2015 Dec 01; 107(Pt B):327-34. PMID: 26169670.
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    16. Ortiz E, Possani LD. The unfulfilled promises of scorpion insectotoxins. J Venom Anim Toxins Incl Trop Dis. 2015; 21:16. PMID: 26085828; PMCID: PMC4470000.
    17. Luna-Ramírez K, Quintero-Hernández V, Juárez-González VR, Possani LD. Whole Transcriptome of the Venom Gland from Urodacus yaschenkoi Scorpion. PLoS One. 2015; 10(5):e0127883. PMID: 26020943; PMCID: PMC4447460.
    18. Espino-Solis GP, Quintero-Hernandez V, Olvera-Rodriguez A, Calderon-Amador J, Pedraza-Escalona M, Licea-Navarro A, Flores-Romo L, Possani LD. Novel monoclonal antibody against alphaX subunit from horse CD11c/CD18 integrin. Vet Immunol Immunopathol. 2015 Apr 15; 164(3-4):220-6. PMID: 25727181.
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    19. Quintero-Hernández V, Ramírez-Carreto S, Romero-Gutiérrez MT, Valdez-Velázquez LL, Becerril B, Possani LD, Ortiz E. Transcriptome analysis of scorpion species belonging to the Vaejovis genus. PLoS One. 2015; 10(2):e0117188. PMID: 25659089; PMCID: PMC4319844.
    20. Okada M, Corzo G, Romero-Perez GA, Coronas F, Matsuda H, Possani LD. A pore forming peptide from spider Lachesana sp. venom induced neuronal depolarization and pain. Biochim Biophys Acta. 2015 Apr; 1850(4):657-66. PMID: 25484315.
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    21. Ortiz E, Gurrola GB, Schwartz EF, Possani LD. Scorpion venom components as potential candidates for drug development. Toxicon. 2015 Jan; 93:125-35. PMID: 25432067.
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    22. Coronas FI, Diego-García E, Restano-Cassulini R, de Roodt AR, Possani LD. Biochemical and physiological characterization of a new Na(+)-channel specific peptide from the venom of the Argentinean scorpion Tityus trivittatus. Peptides. 2015 Jun; 68:11-6. PMID: 24862827.
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    23. Picco C, Corzo G, Possani LD, Prestipino G. Interaction of the scorpion toxin discrepin with Kv4.3 channels and A-type K(+) channels in cerebellum granular cells. Biochim Biophys Acta. 2014 Sep; 1840(9):2744-51. PMID: 24845726.
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    24. Escalona MP, Batista CV, Cassulini RR, Rios MS, Coronas FI, Possani LD. A proteomic analysis of the early secondary molecular effects caused by Cn2 scorpion toxin on neuroblastoma cells. J Proteomics. 2014 Dec 05; 111:212-23. PMID: 24792703.
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    25. González-Morales L, Pedraza-Escalona M, Diego-Garcia E, Restano-Cassulini R, Batista CV, Gutiérrez Mdel C, Possani LD. Proteomic characterization of the venom and transcriptomic analysis of the venomous gland from the Mexican centipede Scolopendra viridis. J Proteomics. 2014 Dec 05; 111:224-37. PMID: 24780725.
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    26. Luna-Ramírez K, Bartok A, Restano-Cassulini R, Quintero-Hernández V, Coronas FI, Christensen J, Wright CE, Panyi G, Possani LD. Structure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi. Mol Pharmacol. 2014 Jul; 86(1):28-41. PMID: 24723491.
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    27. Vergara I, Pedraza-Escalona M, Paniagua D, Restano-Cassulini R, Zamudio F, Batista CV, Possani LD, Alagón A. Eastern coral snake Micrurus fulvius venom toxicity in mice is mainly determined by neurotoxic phospholipases A2. J Proteomics. 2014 Jun 13; 105:295-306. PMID: 24613619.
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    28. Ortiz E, Rendón-Anaya M, Rego SC, Schwartz EF, Possani LD. Antarease-like Zn-metalloproteases are ubiquitous in the venom of different scorpion genera. Biochim Biophys Acta. 2014 Jun; 1840(6):1738-46. PMID: 24361608.
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    29. Luna-Ramírez K, Sani MA, Silva-Sanchez J, Jiménez-Vargas JM, Reyna-Flores F, Winkel KD, Wright CE, Possani LD, Separovic F. Membrane interactions and biological activity of antimicrobial peptides from Australian scorpion. Biochim Biophys Acta. 2014 Sep; 1838(9):2140-8. PMID: 24200946.
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    30. Rodríguez-Ravelo R, Restano-Cassulini R, Zamudio FZ, Coronas FI, Espinosa-López G, Possani LD. A K? channel blocking peptide from the Cuban scorpion Rhopalurus garridoi. Peptides. 2014 Mar; 53:42-7. PMID: 24512947.
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    31. Riaño-Umbarila L, Olamendi-Portugal T, Morelos-Juárez C, Gurrola GB, Possani LD, Becerril B. A novel human recombinant antibody fragment capable of neutralizing Mexican scorpion toxins. Toxicon. 2013 Dec 15; 76:370-6. PMID: 24067940.
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    32. Abdel-Rahman MA, Quintero-Hernandez V, Possani LD. Venom proteomic and venomous glands transcriptomic analysis of the Egyptian scorpion Scorpio maurus palmatus (Arachnida: Scorpionidae). Toxicon. 2013 Nov; 74:193-207. PMID: 23998939.
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    33. Quintero-Hernández V, Jiménez-Vargas JM, Gurrola GB, Valdivia HH, Possani LD. Scorpion venom components that affect ion-channels function. Toxicon. 2013 Dec 15; 76:328-42. PMID: 23891887; PMCID: PMC4089097.
    34. Valdez-Velázquez LL, Quintero-Hernández V, Romero-Gutiérrez MT, Coronas FI, Possani LD. Mass fingerprinting of the venom and transcriptome of venom gland of scorpion Centruroides tecomanus. PLoS One. 2013; 8(6):e66486. PMID: 23840487; PMCID: PMC3688770.
    35. Deuis JR, Zimmermann K, Romanovsky AA, Possani LD, Cabot PJ, Lewis RJ, Vetter I. An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways. Pain. 2013 Sep; 154(9):1749-57. PMID: 23711479; PMCID: PMC3748219.
    36. Rodríguez-Ravelo R, Coronas FI, Zamudio FZ, González-Morales L, López GE, Urquiola AR, Possani LD. The Cuban scorpion Rhopalurus junceus (Scorpiones, Buthidae): component variations in venom samples collected in different geographical areas. J Venom Anim Toxins Incl Trop Dis. 2013 May 20; 19(1):13. PMID: 23849540; PMCID: PMC3710086.
    37. Schwartz EF, Bartok A, Schwartz CA, Papp F, Gómez-Lagunas F, Panyi G, Possani LD. OcyKTx2, a new K?-channel toxin characterized from the venom of the scorpion Opisthacanthus cayaporum. Peptides. 2013 Aug; 46:40-6. PMID: 23684923.
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    38. Bernáldez J, Román-González SA, Martínez O, Jiménez S, Vivas O, Arenas I, Corzo G, Arreguín R, García DE, Possani LD, Licea A. A Conus regularis conotoxin with a novel eight-cysteine framework inhibits CaV2.2 channels and displays an anti-nociceptive activity. Mar Drugs. 2013 Apr 08; 11(4):1188-202. PMID: 23567319; PMCID: PMC3705398.
    39. Mourão CB, Heghinian MD, Barbosa EA, Marí F, Bloch C, Restano-Cassulini R, Possani LD, Schwartz EF. Characterization of a novel peptide toxin from Acanthoscurria paulensis spider venom: a distinct cysteine assignment to the HWTX-II family. Biochemistry. 2013 Apr 09; 52(14):2440-52. PMID: 23496776.
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    40. Sánchez-Vásquez L, Silva-Sanchez J, Jiménez-Vargas JM, Rodríguez-Romero A, Muñoz-Garay C, Rodríguez MC, Gurrola GB, Possani LD. Enhanced antimicrobial activity of novel synthetic peptides derived from vejovine and hadrurin. Biochim Biophys Acta. 2013 Jun; 1830(6):3427-36. PMID: 23403131.
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    41. Caliskan F, Quintero-Hernández V, Restano-Cassulini R, Coronas-Valderrama FI, Corzo G, Possani LD. Molecular cloning and biochemical characterization of the first Na(+)-channel a-type toxin peptide (Acra4) from Androctonus crassicauda scorpion venom. Biochimie. 2013 Jun; 95(6):1216-22. PMID: 23395751.
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    42. Aguilar MB, Ortiz E, Kaas Q, López-Vera E, Becerril B, Possani LD, de la Cotera EP. Precursor De13.1 from Conus delessertii defines the novel G gene superfamily. Peptides. 2013 Mar; 41:17-20. PMID: 23340018.
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    43. Pedraza Escalona M, Possani LD. Scorpion beta-toxins and voltage-gated sodium channels: interactions and effects. Front Biosci (Landmark Ed). 2013 Jan 01; 18:572-87. PMID: 23276943.
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    44. Luna-Ramírez K, Quintero-Hernández V, Vargas-Jaimes L, Batista CV, Winkel KD, Possani LD. Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity. Toxicon. 2013 Mar 01; 63:44-54. PMID: 23182832.
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    45. Wang X, Jimenez-Vargas JM, Xu C, Possani LD, Zhu S. Positive selection-guided mutational analysis revealing two key functional sites of scorpion ERG K(+) channel toxins. Biochem Biophys Res Commun. 2012 Dec 07; 429(1-2):111-6. PMID: 23103547.
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    46. Garcia F, Villegas E, Espino-Solis GP, Rodriguez A, Paniagua-Solis JF, Sandoval-Lopez G, Possani LD, Corzo G. Antimicrobial peptides from arachnid venoms and their microbicidal activity in the presence of commercial antibiotics. J Antibiot (Tokyo). 2013 Jan; 66(1):3-10. PMID: 23093034.
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    47. Clement H, Costa de Oliveira V, Zamudio FZ, Lago NR, Valdez-Cruz NA, Bérnard Valle M, Hajos SE, Alagón A, Possani LD, de Roodt AR. Isolation, amino acid sequence and biological characterization of an "aspartic-49" phospholipase A2 from Bothrops (Rhinocerophis) ammodytoides venom. Toxicon. 2012 Dec 01; 60(7):1314-23. PMID: 22975267.
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    48. Clement H, Olvera A, Rodríguez M, Zamudio F, Palomares LA, Possani LD, Odell GV, Alagón A, Sánchez-López R. Identification, cDNA cloning and heterologous expression of a hyaluronidase from the tarantula Brachypelma vagans venom. Toxicon. 2012 Dec 01; 60(7):1223-7. PMID: 22982117.
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    49. Rendón-Anaya M, Delaye L, Possani LD, Herrera-Estrella A. Global transcriptome analysis of the scorpion Centruroides noxius: new toxin families and evolutionary insights from an ancestral scorpion species. PLoS One. 2012; 7(8):e43331. PMID: 22912855; PMCID: PMC3422302.
    50. Rodríguez-Rodríguez ER, Ledezma-Candanoza LM, Contreras-Ferrat LG, Olamendi-Portugal T, Possani LD, Becerril B, Riaño-Umbarila L. A single mutation in framework 2 of the heavy variable domain improves the properties of a diabody and a related single-chain antibody. J Mol Biol. 2012 Oct 26; 423(3):337-50. PMID: 22835504.
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    51. Caliskan F, García BI, Coronas FI, Restano-Cassulini R, Korkmaz F, Sahin Y, Corzo G, Possani LD. Purification and cDNA cloning of a novel neurotoxic peptide (Acra3) from the scorpion Androctonus crassicauda. Peptides. 2012 Sep; 37(1):106-12. PMID: 22819772.
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    52. Varga Z, Gurrola-Briones G, Papp F, Rodríguez de la Vega RC, Pedraza-Alva G, Tajhya RB, Gaspar R, Cardenas L, Rosenstein Y, Beeton C, Possani LD, Panyi G. Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells. Mol Pharmacol. 2012 Sep; 82(3):372-82. PMID: 22622363; PMCID: PMC3422703.
    53. Gurrola GB, Hernández-López RA, Rodríguez de la Vega RC, Varga Z, Batista CV, Salas-Castillo SP, Panyi G, del Río-Portilla F, Possani LD. Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes. Biochemistry. 2012 May 15; 51(19):4049-61. PMID: 22540187.
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    54. Jiménez-Vargas JM, Restano-Cassulini R, Possani LD. Toxin modulators and blockers of hERG K(+) channels. Toxicon. 2012 Sep 15; 60(4):492-501. PMID: 22497787.
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    55. Jimenez-Vargas JM, Restano-Cassulini R, Possani LD. Interacting sites of scorpion toxin ErgTx1 with hERG1 K+ channels. Toxicon. 2012 May; 59(6):633-41. PMID: 22366117.
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    56. Guerrero-Vargas JA, Mourão CB, Quintero-Hernández V, Possani LD, Schwartz EF. Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscurus novel putative Na+-channel scorpion toxins. PLoS One. 2012; 7(2):e30478. PMID: 22355312; PMCID: PMC3280238.
    57. Ramírez-Carreto S, Quintero-Hernández V, Jiménez-Vargas JM, Corzo G, Possani LD, Becerril B, Ortiz E. Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae. Peptides. 2012 Apr; 34(2):290-5. PMID: 22342498.
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    58. Quintero-Hernández V, Del Pozo-Yauner L, Pedraza-Escalona M, Juárez-González VR, Alcántara-Recillas I, Possani LD, Becerril B. Evaluation of three different formats of a neutralizing single chain human antibody against toxin Cn2: neutralization capacity versus thermodynamic stability. Immunol Lett. 2012 Apr 30; 143(2):152-60. PMID: 22306104.
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    59. Saucedo AL, del Rio-Portilla F, Picco C, Estrada G, Prestipino G, Possani LD, Delepierre M, Corzo G. Solution structure of native and recombinant expressed toxin CssII from the venom of the scorpion Centruroides suffusus suffusus, and their effects on Nav1.5 sodium channels. Biochim Biophys Acta. 2012 Mar; 1824(3):478-87. PMID: 22251893.
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    60. Caliskan F, Quintero-Hernández V, Restano-Cassulini R, Batista CV, Zamudio FZ, Coronas FI, Possani LD. Turkish scorpion Buthacus macrocentrus: general characterization of the venom and description of Bu1, a potent mammalian Na?-channel a-toxin. Toxicon. 2012 Mar 01; 59(3):408-15. PMID: 22245624.
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    61. Schiavon E, Pedraza-Escalona M, Gurrola GB, Olamendi-Portugal T, Corzo G, Wanke E, Possani LD. Negative-shift activation, current reduction and resurgent currents induced by ß-toxins from Centruroides scorpions in sodium channels. Toxicon. 2012 Feb; 59(2):283-93. PMID: 22200496.
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    62. Quintero-Hernández V, Ortiz E, Rendón-Anaya M, Schwartz EF, Becerril B, Corzo G, Possani LD. Scorpion and spider venom peptides: gene cloning and peptide expression. Toxicon. 2011 Dec 01; 58(8):644-63. PMID: 21978889.
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    63. Camargos TS, Restano-Cassulini R, Possani LD, Peigneur S, Tytgat J, Schwartz CA, Alves EM, de Freitas SM, Schwartz EF. The new kappa-KTx 2.5 from the scorpion Opisthacanthus cayaporum. Peptides. 2011 Jul; 32(7):1509-17. PMID: 21624408.
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    64. Amaro I, Riaño-Umbarila L, Becerril B, Possani LD. Isolation and characterization of a human antibody fragment specific for Ts1 toxin from Tityus serrulatus scorpion. Immunol Lett. 2011 Sep 30; 139(1-2):73-9. PMID: 21620895.
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    65. García-Gómez BI, Coronas FI, Restano-Cassulini R, Rodríguez RR, Possani LD. Biochemical and molecular characterization of the venom from the Cuban scorpion Rhopalurus junceus. Toxicon. 2011 Jul; 58(1):18-27. PMID: 21605585.
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    66. Canul-Tec JC, Riaño-Umbarila L, Rudiño-Piñera E, Becerril B, Possani LD, Torres-Larios A. Structural basis of neutralization of the major toxic component from the scorpion Centruroides noxius Hoffmann by a human-derived single-chain antibody fragment. J Biol Chem. 2011 Jun 10; 286(23):20892-900. PMID: 21489992; PMCID: PMC3121463.
    67. Espino-Solis GP, Estrada G, Olamendi-Portugal T, Villegas E, Zamudio F, Cestele S, Possani LD, Corzo G. Isolation and molecular cloning of beta-neurotoxins from the venom of the scorpion Centruroides suffusus suffusus. Toxicon. 2011 Apr; 57(5):739-46. PMID: 21329715.
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    68. Riaño-Umbarila L, Contreras-Ferrat G, Olamendi-Portugal T, Morelos-Juárez C, Corzo G, Possani LD, Becerril B. Exploiting cross-reactivity to neutralize two different scorpion venoms with one single chain antibody fragment. J Biol Chem. 2011 Feb 25; 286(8):6143-51. PMID: 21156801; PMCID: PMC3057807.
    69. Estrada G, Restano-Cassulini R, Ortiz E, Possani LD, Corzo G. Addition of positive charges at the C-terminal peptide region of CssII, a mammalian scorpion peptide toxin, improves its affinity for sodium channels Nav1.6. Peptides. 2011 Jan; 32(1):75-9. PMID: 21078353.
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    70. Hernández-Aponte CA, Silva-Sanchez J, Quintero-Hernández V, Rodríguez-Romero A, Balderas C, Possani LD, Gurrola GB. Vejovine, a new antibiotic from the scorpion venom of Vaejovis mexicanus. Toxicon. 2011 Jan; 57(1):84-92. PMID: 20969885.
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    71. Jimenez-Vargas JM, Restano-Cassulini R, Quintero-Hernández V, Gurrola GB, Possani LD. Recombinant expression of the toxic peptide ErgTx1 and role of Met35 on its stability and function. Peptides. 2011 Mar; 32(3):560-7. PMID: 20600425.
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    72. Vandendriessche T, Olamendi-Portugal T, Zamudio FZ, Possani LD, Tytgat J. Isolation and characterization of two novel scorpion toxins: The alpha-toxin-like CeII8, specific for Na(v)1.7 channels and the classical anti-mammalian CeII9, specific for Na(v)1.4 channels. Toxicon. 2010 Sep 15; 56(4):613-23. PMID: 20600228.
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    73. Gurrola GB, Capes EM, Zamudio FZ, Possani LD, Valdivia HH. Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca(2+)-Release Channels/Ryanodine Receptors. Pharmaceuticals (Basel). 2010 Apr 13; 3(4):1093-1107. PMID: 27713290.
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    74. Corrales-Garcia LL, Possani LD, Corzo G. Expression systems of human ß-defensins: vectors, purification and biological activities. Amino Acids. 2011 Jan; 40(1):5-13. PMID: 20306097.
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    75. Zhu S, Gao B, Aumelas A, del Carmen Rodríguez M, Lanz-Mendoza H, Peigneur S, Diego-Garcia E, Martin-Eauclaire MF, Tytgat J, Possani LD. MeuTXKbeta1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity. Biochim Biophys Acta. 2010 Apr; 1804(4):872-83. PMID: 20045493.
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    76. Rodríguez A, Villegas E, Satake H, Possani LD, Corzo G. Amino acid substitutions in an alpha-helical antimicrobial arachnid peptide affect its chemical properties and biological activity towards pathogenic bacteria but improves its therapeutic index. Amino Acids. 2011 Jan; 40(1):61-8. PMID: 20033827.
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    77. Redaelli E, Cassulini RR, Silva DF, Clement H, Schiavon E, Zamudio FZ, Odell G, Arcangeli A, Clare JJ, Alagón A, de la Vega RC, Possani LD, Wanke E. Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels. J Biol Chem. 2010 Feb 05; 285(6):4130-42. PMID: 19955179; PMCID: PMC2823553.
    78. Rodríguez de la Vega RC, Schwartz EF, Possani LD. Mining on scorpion venom biodiversity. Toxicon. 2010 Dec 15; 56(7):1155-61. PMID: 19931296.
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    79. de Roodt AR, Coronas FI, Lago N, González ME, Laskowicz RD, Beltramino JC, Saavedra S, López RA, Reati GJ, Vucharchuk MG, Bazán E, Varni L, Salomón OD, Possani LD. General biochemical and immunological characterization of the venom from the scorpion Tityus trivittatus of Argentina. Toxicon. 2010 Feb-Mar; 55(2-3):307-19. PMID: 19706301.
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    80. Corzo G, Prochnicka-Chalufour A, García BI, Possani LD, Delepierre M. Solution structure of Cn5, a crustacean toxin found in the venom of the scorpions Centruroides noxius and Centruroides suffusus suffusus. Biochim Biophys Acta. 2009 Nov; 1794(11):1591-8. PMID: 19631296.
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    81. Espino-Solis GP, Calderon-Amador J, Calderon-Aranda ES, Licea AF, Donis-Maturano L, Flores-Romo L, Possani LD. Rational design of synthetic peptides to generate antibodies that recognize in situ CD11c(+) putative dendritic cells in horse lymph nodes. Vet Immunol Immunopathol. 2009 Dec 15; 132(2-4):181-90. PMID: 19682754.
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    82. Hernández-Salgado K, Estrada G, Olvera A, Coronas FI, Possani LD, Corzo G. Heterologous expressed toxic and non-toxic peptide variants of toxin CssII are capable to produce neutralizing antibodies against the venom of the scorpion Centruroides suffusus suffusus. Immunol Lett. 2009 Aug 15; 125(2):93-9. PMID: 19524619.
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    83. Papp F, Batista CV, Varga Z, Herceg M, Román-González SA, Gaspar R, Possani LD, Panyi G. Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus. Toxicon. 2009 Sep 15; 54(4):379-89. PMID: 19500613.
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    84. D'Suze G, Schwartz EF, García-Gómez BI, Sevcik C, Possani LD. Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepans. Biochimie. 2009 Aug; 91(8):1010-9. PMID: 19470401.
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    85. Kauferstein S, Kendel Y, Nicke A, Coronas FI, Possani LD, Favreau P, Krizaj I, Wunder C, Kauert G, Mebs D. New conopeptides of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine receptors. Toxicon. 2009 Sep 01; 54(3):295-301. PMID: 19393680.
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    86. Silva EC, Camargos TS, Maranhão AQ, Silva-Pereira I, Silva LP, Possani LD, Schwartz EF. Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum. Toxicon. 2009 Sep 01; 54(3):252-61. PMID: 19379768.
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    87. Schwartz EF, Capes EM, Diego-García E, Zamudio FZ, Fuentes O, Possani LD, Valdivia HH. Characterization of hadrucalcin, a peptide from Hadrurus gertschi scorpion venom with pharmacological activity on ryanodine receptors. Br J Pharmacol. 2009 Jun; 157(3):392-403. PMID: 19389159; PMCID: PMC2707986.
    88. Corzo G, Bernard C, Clement H, Villegas E, Bosmans F, Tytgat J, Possani LD, Darbon H, Alagón A. Insecticidal peptides from the theraposid spider Brachypelma albiceps: an NMR-based model of Ba2. Biochim Biophys Acta. 2009 Aug; 1794(8):1190-6. PMID: 19374957.
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    89. González-Morales L, Diego-García E, Segovia L, Gutiérrez Mdel C, Possani LD. Venom from the centipede Scolopendra viridis Say: purification, gene cloning and phylogenetic analysis of a phospholipase A2. Toxicon. 2009 Jul; 54(1):8-15. PMID: 19285520.
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    90. García-Gómez BI, Olamendi-Portugal TC, Paniagua J, van der Walt J, Dyason K, Possani LD. Heterologous expression of a gene that codes for Pg8, a scorpion toxin of Parabuthus granulatus, capable of generating protecting antibodies in mice. Toxicon. 2009 Jun; 53(7-8):770-8. PMID: 19233226.
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    91. Prestipino G, Corzo G, Romeo S, Murgia AR, Zanardi I, Gurrola GB, Possani LD. Scorpion toxins that block transient currents (I(A)) of rat cerebellum granular cells. Toxicol Lett. 2009 May 22; 187(1):1-9. PMID: 19429236.
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    92. Espino-Solis GP, Riaño-Umbarila L, Becerril B, Possani LD. Antidotes against venomous animals: state of the art and prospectives. J Proteomics. 2009 Mar 06; 72(2):183-99. PMID: 19457345.
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    93. Petricevich VL, Reynaud E, Cruz AH, Possani LD. Macrophage activation, phagocytosis and intracellular calcium oscillations induced by scorpion toxins from Tityus serrulatus. Clin Exp Immunol. 2008 Dec; 154(3):415-23. PMID: 19037924; PMCID: PMC2633242.
    94. Carballar-Lejarazú R, Rodríguez MH, de la Cruz Hernández-Hernández F, Ramos-Castañeda J, Possani LD, Zurita-Ortega M, Reynaud-Garza E, Hernández-Rivas R, Loukeris T, Lycett G, Lanz-Mendoza H. Recombinant scorpine: a multifunctional antimicrobial peptide with activity against different pathogens. Cell Mol Life Sci. 2008 Oct; 65(19):3081-92. PMID: 18726072.
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    95. Corzo G, Papp F, Varga Z, Barraza O, Espino-Solis PG, Rodríguez de la Vega RC, Gaspar R, Panyi G, Possani LD. A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus. Biochem Pharmacol. 2008 Oct 30; 76(9):1142-54. PMID: 18786511.
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    96. Abdel-Mottaleb Y, Corzo G, Martin-Eauclaire MF, Satake H, Céard B, Peigneur S, Nambaru P, Bougis PE, Possani LD, Tytgat J. A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels. Biochem Pharmacol. 2008 Sep 15; 76(6):805-15. PMID: 18687312.
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    97. Corzo G, Diego-García E, Clement H, Peigneur S, Odell G, Tytgat J, Possani LD, Alagón A. An insecticidal peptide from the theraposid Brachypelma smithi spider venom reveals common molecular features among spider species from different genera. Peptides. 2008 Nov; 29(11):1901-8. PMID: 18687374.
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    98. Olamendi-Portugal T, Batista CV, Restano-Cassulini R, Pando V, Villa-Hernandez O, Zavaleta-Martínez-Vargas A, Salas-Arruz MC, Rodríguez de la Vega RC, Becerril B, Possani LD. Proteomic analysis of the venom from the fish eating coral snake Micrurus surinamensis: novel toxins, their function and phylogeny. Proteomics. 2008 May; 8(9):1919-32. PMID: 18384102.
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    99. Schwartz EF, Camargos TS, Zamudio FZ, Silva LP, Bloch C, Caixeta F, Schwartz CA, Possani LD. Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum. Toxicon. 2008 Jun 15; 51(8):1499-508. PMID: 18502464.
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    100. Restano-Cassulini R, Olamendi-Portugal T, Zamudio F, Becerril B, Possani LD. Two novel ergtoxins, blockers of K+-channels, purified from the Mexican scorpion Centruroides elegans elegans. Neurochem Res. 2008 Aug; 33(8):1525-33. PMID: 18338253.
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    101. Romeo S, Corzo G, Vasile A, Satake H, Prestipino G, Possani LD. A positive charge at the N-terminal segment of Discrepin increases the blocking effect of K+ channels responsible for the IA currents in cerebellum granular cells. Biochim Biophys Acta. 2008 Apr; 1780(4):750-5. PMID: 18280256.
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    102. Espino-Solis GP, Osuna-Quintero J, Possani LD. Molecular cloning and characterization of the alphaX subunit from CD11c/CD18 horse integrin. Vet Immunol Immunopathol. 2008 Apr 15; 122(3-4):326-34. PMID: 18261807.
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    103. Diego-García E, Abdel-Mottaleb Y, Schwartz EF, de la Vega RC, Tytgat J, Possani LD. Cytolytic and K+ channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms. Cell Mol Life Sci. 2008 Jan; 65(1):187-200. PMID: 18030427.
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    104. López-Vera E, Aguilar MB, Schiavon E, Marinzi C, Ortiz E, Restano Cassulini R, Batista CV, Possani LD, Heimer de la Cotera EP, Peri F, Becerril B, Wanke E. Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS J. 2007 Aug; 274(15):3972-85. PMID: 17635581.
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    105. Petricevich VL, Hernández Cruz A, Coronas FI, Possani LD. Toxin gamma from Tityus serrulatus scorpion venom plays an essential role in immunomodulation of macrophages. Toxicon. 2007 Oct; 50(5):666-75. PMID: 17675201.
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    106. Schwartz EF, Diego-Garcia E, Rodríguez de la Vega RC, Possani LD. Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones). BMC Genomics. 2007 May 16; 8:119. PMID: 17506894; PMCID: PMC1904202.
    107. Estrada G, Garcia BI, Schiavon E, Ortiz E, Cestele S, Wanke E, Possani LD, Corzo G. Four disulfide-bridged scorpion beta neurotoxin CssII: heterologous expression and proper folding in vitro. Biochim Biophys Acta. 2007 Aug; 1770(8):1161-8. PMID: 17544584.
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    108. Valdez-Cruz NA, Segovia L, Corona M, Possani LD. Sequence analysis and phylogenetic relationship of genes encoding heterodimeric phospholipases A2 from the venom of the scorpion Anuroctonus phaiodactylus. Gene. 2007 Jul 01; 396(1):149-58. PMID: 17466468.
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    109. Clement H, Odell G, Zamudio FZ, Redaelli E, Wanke E, Alagón A, Possani LD. Isolation and characterization of a novel toxin from the venom of the spider Grammostola rosea that blocks sodium channels. Toxicon. 2007 Jul; 50(1):65-74. PMID: 17418351.
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    110. Batista CV, Román-González SA, Salas-Castillo SP, Zamudio FZ, Gómez-Lagunas F, Possani LD. Proteomic analysis of the venom from the scorpion Tityus stigmurus: biochemical and physiological comparison with other Tityus species. Comp Biochem Physiol C Toxicol Pharmacol. 2007 Jul-Aug; 146(1-2):147-57. PMID: 17270501.
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    111. Diego-García E, Schwartz EF, D'Suze G, González SA, Batista CV, García BI, de la Vega RC, Possani LD. Wide phylogenetic distribution of Scorpine and long-chain beta-KTx-like peptides in scorpion venoms: identification of "orphan" components. Peptides. 2007 Jan; 28(1):31-7. PMID: 17141373.
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    112. de la Vega RC, Possani LD. Novel paradigms on scorpion toxins that affects the activating mechanism of sodium channels. Toxicon. 2007 Feb; 49(2):171-80. PMID: 17081580.
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    113. Schwartz EF, Schwartz CA, Gómez-Lagunas F, Zamudio FZ, Possani LD. HgeTx1, the first K+-channel specific toxin characterized from the venom of the scorpion Hadrurus gertschi Soleglad. Toxicon. 2006 Dec 15; 48(8):1046-53. PMID: 17030052.
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    114. Quintero-Hernández V, Juárez-González VR, Ortíz-León M, Sánchez R, Possani LD, Becerril B. The change of the scFv into the Fab format improves the stability and in vivo toxin neutralization capacity of recombinant antibodies. Mol Immunol. 2007 Feb; 44(6):1307-15. PMID: 16814388.
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    115. Batista CV, D'Suze G, Gómez-Lagunas F, Zamudio FZ, Encarnación S, Sevcik C, Possani LD. Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins. Proteomics. 2006 Jun; 6(12):3718-27. PMID: 16705749.
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    116. Schiavon E, Sacco T, Cassulini RR, Gurrola G, Tempia F, Possani LD, Wanke E. Resurgent current and voltage sensor trapping enhanced activation by a beta-scorpion toxin solely in Nav1.6 channel. Significance in mice Purkinje neurons. J Biol Chem. 2006 Jul 21; 281(29):20326-37. PMID: 16702217.
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    117. Caliskan F, García BI, Coronas FI, Batista CV, Zamudio FZ, Possani LD. Characterization of venom components from the scorpion Androctonus crassicauda of Turkey: peptides and genes. Toxicon. 2006 Jul; 48(1):12-22. PMID: 16762386.
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    118. Mebs D, Kuch U, Coronas FI, Batista CV, Gumprecht A, Possani LD. Biochemical and biological activities of the venom of the Chinese pitviper Zhaoermia mangshanensis, with the complete amino acid sequence and phylogenetic analysis of a novel Arg49 phospholipase A2 myotoxin. Toxicon. 2006 Jun 01; 47(7):797-811. PMID: 16635500.
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    119. Restano-Cassulini R, Korolkova YV, Diochot S, Gurrola G, Guasti L, Possani LD, Lazdunski M, Grishin EV, Arcangeli A, Wanke E. Species diversity and peptide toxins blocking selectivity of ether-a-go-go-related gene subfamily K+ channels in the central nervous system. Mol Pharmacol. 2006 May; 69(5):1673-83. PMID: 16497878.
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    120. Prochnicka-Chalufour A, Corzo G, Satake H, Martin-Eauclaire MF, Murgia AR, Prestipino G, D'Suze G, Possani LD, Delepierre M. Solution structure of discrepin, a new K+-channel blocking peptide from the alpha-KTx15 subfamily. Biochemistry. 2006 Feb 14; 45(6):1795-804. PMID: 16460026.
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    121. Abdel-Mottaleb Y, Coronas FV, de Roodt AR, Possani LD, Tytgat J. A novel toxin from the venom of the scorpion Tityus trivittatus, is the first member of a new alpha-KTX subfamily. FEBS Lett. 2006 Jan 23; 580(2):592-6. PMID: 16405970.
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    122. Panyi G, Possani LD, Rodríguez de la Vega RC, Gáspár R, Varga Z. K+ channel blockers: novel tools to inhibit T cell activation leading to specific immunosuppression. Curr Pharm Des. 2006; 12(18):2199-220. PMID: 16787250.
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    123. Rodríguez de la Vega RC, Possani LD. Overview of scorpion toxins specific for Na+ channels and related peptides: biodiversity, structure-function relationships and evolution. Toxicon. 2005 Dec 15; 46(8):831-44. PMID: 16274721.
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    124. Olamendi-Portugal T, Somodi S, Fernández JA, Zamudio FZ, Becerril B, Varga Z, Panyi G, Gáspár R, Possani LD. Novel alpha-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockade Kv1.3 over IKCa1 K+ channels of T cells. Toxicon. 2005 Sep 15; 46(4):418-29. PMID: 16026809.
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    125. Barona J, Batista CV, Zamudio FZ, Gomez-Lagunas F, Wanke E, Otero R, Possani LD. Proteomic analysis of the venom and characterization of toxins specific for Na+ - and K+ -channels from the Colombian scorpion Tityus pachyurus. Biochim Biophys Acta. 2006 Jan; 1764(1):76-84. PMID: 16309982.
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    126. Aguilar MB, López-Vera E, Ortiz E, Becerril B, Possani LD, Olivera BM, Heimer de la Cotera EP. A novel conotoxin from Conus delessertii with posttranslationally modified lysine residues. Biochemistry. 2005 Aug 23; 44(33):11130-6. PMID: 16101297.
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    127. Padilla A, Govezensky T, Possani LD, Larralde C. Mortality and antibody responses of mice to three successive episodes of experimental scorpion (Centruroides limpidus limpidus) envenomation and immunological rescue. Toxicon. 2005 Aug; 46(2):142-9. PMID: 15946719.
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    128. Rodríguez de la Vega RC, Possani LD. On the evolution of invertebrate defensins. Trends Genet. 2005 Jun; 21(6):330-2. PMID: 15922831.
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    129. Gazarian KG, Gazarian T, Hernández R, Possani LD. Immunology of scorpion toxins and perspectives for generation of anti-venom vaccines. Vaccine. 2005 May 16; 23(26):3357-68. PMID: 15837360.
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    130. Riaño-Umbarila L, Juárez-González VR, Olamendi-Portugal T, Ortíz-León M, Possani LD, Becerril B. A strategy for the generation of specific human antibodies by directed evolution and phage display. An example of a single-chain antibody fragment that neutralizes a major component of scorpion venom. FEBS J. 2005 May; 272(10):2591-601. PMID: 15885107.
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    131. Juárez-González VR, Riaño-Umbarila L, Quintero-Hernández V, Olamendi-Portugal T, Ortiz-León M, Ortíz E, Possani LD, Becerril B. Directed evolution, phage display and combination of evolved mutants: a strategy to recover the neutralization properties of the scFv version of BCF2 a neutralizing monoclonal antibody specific to scorpion toxin Cn2. J Mol Biol. 2005 Mar 11; 346(5):1287-97. PMID: 15713481.
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    132. Bagdány M, Batista CV, Valdez-Cruz NA, Somodi S, Rodriguez de la Vega RC, Licea AF, Varga Z, Gáspár R, Possani LD, Panyi G. Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes. Mol Pharmacol. 2005 Apr; 67(4):1034-44. PMID: 15615696.
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    133. Diego-García E, Batista CV, García-Gómez BI, Lucas S, Candido DM, Gómez-Lagunas F, Possani LD. The Brazilian scorpion Tityus costatus Karsch: genes, peptides and function. Toxicon. 2005 Mar 01; 45(3):273-83. PMID: 15683865.
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    134. Valdez-Cruz NA, Batista CV, Zamudio FZ, Bosmans F, Tytgat J, Possani LD. Phaiodotoxin, a novel structural class of insect-toxin isolated from the venom of the Mexican scorpion Anuroctonus phaiodactylus. Eur J Biochem. 2004 Dec; 271(23-24):4753-61. PMID: 15606762.
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    135. D'Suze G, Batista CV, Frau A, Murgia AR, Zamudio FZ, Sevcik C, Possani LD, Prestipino G. Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K+ -channels (IA currents) of cerebellum granular cells. Arch Biochem Biophys. 2004 Oct 15; 430(2):256-63. PMID: 15369825.
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    136. Frénal K, Xu CQ, Wolff N, Wecker K, Gurrola GB, Zhu SY, Chi CW, Possani LD, Tytgat J, Delepierre M. Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K+ channels. Proteins. 2004 Aug 01; 56(2):367-75. PMID: 15211519.
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    137. Rodríguez de la Vega RC, Possani LD. Current views on scorpion toxins specific for K+-channels. Toxicon. 2004 Jun 15; 43(8):865-75. PMID: 15208019.
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    138. Valdez-Cruz NA, Dávila S, Licea A, Corona M, Zamudio FZ, García-Valdes J, Boyer L, Possani LD. Biochemical, genetic and physiological characterization of venom components from two species of scorpions: Centruroides exilicauda Wood and Centruroides sculpturatus Ewing. Biochimie. 2004 Jun; 86(6):387-96. PMID: 15358055.
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    139. del Río-Portilla F, Hernández-Marín E, Pimienta G, Coronas FV, Zamudio FZ, Rodríguez de la Vega RC, Wanke E, Possani LD. NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical beta-toxin sequence but with alpha-like physiological activity. Eur J Biochem. 2004 Jun; 271(12):2504-16. PMID: 15182366.
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    140. Rodríguez de la Vega RC, García BI, D'Ambrosio C, Diego-García E, Scaloni A, Possani LD. Antimicrobial peptide induction in the haemolymph of the Mexican scorpion Centruroides limpidus limpidus in response to septic injury. Cell Mol Life Sci. 2004 Jun; 61(12):1507-19. PMID: 15197474.
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    141. Murgia AR, Batista CV, Prestipino G, Possani LD. Amino acid sequence and function of a new alpha-toxin from the Amazonian scorpion Tityus cambridgei. Toxicon. 2004 May; 43(6):737-40. PMID: 15109895.
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    142. Batista CV, del Pozo L, Zamudio FZ, Contreras S, Becerril B, Wanke E, Possani LD. Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Apr 15; 803(1):55-66. PMID: 15025998.
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    143. Zhu X, Zamudio FZ, Olbinski BA, Possani LD, Valdivia HH. Activation of skeletal ryanodine receptors by two novel scorpion toxins from Buthotus judaicus. J Biol Chem. 2004 Jun 18; 279(25):26588-96. PMID: 15067003.
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    144. Valdez-Cruz NA, Batista CV, Possani LD. Phaiodactylipin, a glycosylated heterodimeric phospholipase A from the venom of the scorpion Anuroctonus phaiodactylus. Eur J Biochem. 2004 Apr; 271(8):1453-64. PMID: 15066171.
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    145. Gómez-Lagunas F, Batista CV, Olamendi-Portugal T, Ramírez-Domínguez ME, Possani LD. Inhibition of the collapse of the Shaker K+ conductance by specific scorpion toxins. J Gen Physiol. 2004 Mar; 123(3):265-79. PMID: 14981137; PMCID: PMC2217447.
    146. D'Suze G, Sevcik C, Corona M, Zamudio FZ, Batista CV, Coronas FI, Possani LD. Ardiscretin a novel arthropod-selective toxin from Tityus discrepans scorpion venom. Toxicon. 2004 Mar 01; 43(3):263-72. PMID: 15033324.
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    147. Selisko B, Cosío G, García C, Becerril B, Possani LD, Horjales E. Bacterial expression, purification and functional characterization of a recombinant chimeric Fab derived from murine mAb BCF2 that neutralizes the venom of the scorpion Centruroides noxius hoffmann. Toxicon. 2004 Jan; 43(1):43-51. PMID: 15037028.
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    148. Pascual I, Gil-Parrado S, Cisneros M, Joseph-Bravo P, Díaz J, Possani LD, Charli JL, Chávez M. Purification of a specific inhibitor of pyroglutamyl aminopeptidase II from the marine annelide Hermodice carunculata. in vivo effects in rodent brain. Int J Biochem Cell Biol. 2004 Jan; 36(1):138-52. PMID: 14592539.
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    149. Shalabi A, Zamudio F, Wu X, Scaloni A, Possani LD, Villereal ML. Tetrapandins, a new class of scorpion toxins that specifically inhibit store-operated calcium entry in human embryonic kidney-293 cells. J Biol Chem. 2004 Jan 09; 279(2):1040-9. PMID: 14583617.
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    150. Huys I, Olamendi-Portugal T, Garcia-Gómez BI, Vandenberghe I, Van Beeumen J, Dyason K, Clynen E, Zhu S, van der Walt J, Possani LD, Tytgat J. A subfamily of acidic alpha-K(+) toxins. J Biol Chem. 2004 Jan 23; 279(4):2781-9. PMID: 14561751.
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    151. Guijarro JI, M'Barek S, Gómez-Lagunas F, Garnier D, Rochat H, Sabatier JM, Possani L, Delepierre M, Possani L. Solution structure of Pi4, a short four-disulfide-bridged scorpion toxin specific of potassium channels. Protein Sci. 2003 Sep; 12(9):1844-54. PMID: 12930984; PMCID: PMC2323982.
    152. Corona M, Coronas FV, Merino E, Becerril B, Gutiérrez R, Rebolledo-Antunez S, Garcia DE, Possani LD. A novel class of peptide found in scorpion venom with neurodepressant effects in peripheral and central nervous system of the rat. Biochim Biophys Acta. 2003 Jun 26; 1649(1):58-67. PMID: 12818191.
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    153. Gutiérrez Mdel C, Abarca C, Possani LD. A toxic fraction from scolopendra venom increases the basal release of neurotransmitters in the ventral ganglia of crustaceans. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jun; 135(2):205-14. PMID: 12860060.
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    154. Padilla A, Govezensky T, Possani LD, Larralde C. Experimental envenoming of mice with venom from the scorpion Centruroides limpidus limpidus: differences in mortality and symptoms with and without antibody therapy relating to differences in age, sex and strain of mouse. Toxicon. 2003 Jun; 41(8):959-65. PMID: 12875869.
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    155. Coronas FV, Stankiewicz M, Batista CV, Giraud S, Alam JM, Possani LD, Mebs D, Pelhate M. Primary structure and electrophysiological characterization of two almost identical isoforms of toxin from Isometrus vittatus (family: Buthidae) scorpion venom. Toxicon. 2003 Jun; 41(8):989-97. PMID: 12875873.
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    156. Possani LD. The past, present, and future of biotechnology in Mexico. Nat Biotechnol. 2003 May; 21(5):582-3. PMID: 12721582.
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    157. Rodríguez de la Vega RC, Merino E, Becerril B, Possani LD. Novel interactions between K+ channels and scorpion toxins. Trends Pharmacol Sci. 2003 May; 24(5):222-7. PMID: 12767720.
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    158. Gazarian TG, Selisko B, Gurrola GB, Hernández R, Possani LD, Gazarian KG. Potential of peptides selected from random phage-displayed libraries to mimic conformational epitopes: a study on scorpion toxin Cn2 and the neutralizing monoclonal antibody BCF2. Comb Chem High Throughput Screen. 2003 Mar; 6(2):119-32. PMID: 12678707.
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    159. Garcia C, Calderón-Aranda ES, Anguiano GA, Becerril B, Possani LD. Analysis of the immune response induced by a scorpion venom sub-fraction, a pure peptide and a recombinant peptide, against toxin Cn2 of Centruroides noxius Hoffmann. Toxicon. 2003 Mar; 41(4):417-27. PMID: 12657311.
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    160. Coronas FV, de Roodt AR, Portugal TO, Zamudio FZ, Batista CV, Gómez-Lagunas F, Possani LD. Disulfide bridges and blockage of Shaker B K(+)-channels by another butantoxin peptide purified from the Argentinean scorpion Tityus trivittatus. Toxicon. 2003 Feb; 41(2):173-9. PMID: 12565736.
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    161. López-González I, Olamendi-Portugal T, De la Vega-Beltrán JL, Van der Walt J, Dyason K, Possani LD, Felix R, Darszon A. Scorpion toxins that block T-type Ca2+ channels in spermatogenic cells inhibit the sperm acrosome reaction. Biochem Biophys Res Commun. 2003 Jan 10; 300(2):408-14. PMID: 12504099.
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    162. Batista CV, Gómez-Lagunas F, Rodríguez de la Vega RC, Hajdu P, Panyi G, Gáspár R, Possani LD. Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K(+)-channels with distinctly different affinities. Biochim Biophys Acta. 2002 Dec 16; 1601(2):123-31. PMID: 12445473.
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    163. Olamendi-Portugal T, García BI, López-González I, Van Der Walt J, Dyason K, Ulens C, Tytgat J, Felix R, Darszon A, Possani LD. Two new scorpion toxins that target voltage-gated Ca2+ and Na+ channels. Biochem Biophys Res Commun. 2002 Dec 13; 299(4):562-8. PMID: 12459175.
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    164. Corona M, Gurrola GB, Merino E, Cassulini RR, Valdez-Cruz NA, García B, Ramírez-Domínguez ME, Coronas FI, Zamudio FZ, Wanke E, Possani LD. A large number of novel Ergtoxin-like genes and ERG K+-channels blocking peptides from scorpions of the genus Centruroides. FEBS Lett. 2002 Dec 04; 532(1-2):121-6. PMID: 12459475.
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    165. Vacher H, Alami M, Crest M, Possani LD, Bougis PE, Martin-Eauclaire MF. Expanding the scorpion toxin alpha-KTX 15 family with AmmTX3 from Androctonus mauretanicus. Eur J Biochem. 2002 Dec; 269(24):6037-41. PMID: 12473099.
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    166. Angulo Y, Olamendi-Portugal T, Alape-Girón A, Possani LD, Lomonte B. Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A(2) homologue. Int J Biochem Cell Biol. 2002 Oct; 34(10):1268-78. PMID: 12127577.
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    167. Possani LD, Corona M, Zurita M, Rodríguez MH. From noxiustoxin to scorpine and possible transgenic mosquitoes resistant to malaria. Arch Med Res. 2002 Jul-Aug; 33(4):398-404. PMID: 12234530.
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    168. Batista CV, Zamudio FZ, Lucas S, Fox JW, Frau A, Prestipino G, Possani LD. Scorpion toxins from Tityus cambridgei that affect Na(+)-channels. Toxicon. 2002 May; 40(5):557-62. PMID: 11821128.
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    169. Lecchi M, Redaelli E, Rosati B, Gurrola G, Florio T, Crociani O, Curia G, Cassulini RR, Masi A, Arcangeli A, Olivotto M, Schettini G, Possani LD, Wanke E. Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release. J Neurosci. 2002 May 01; 22(9):3414-25. PMID: 11978818.
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    170. Corzo G, Villegas E, Gómez-Lagunas F, Possani LD, Belokoneva OS, Nakajima T. Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins. J Biol Chem. 2002 Jun 28; 277(26):23627-37. PMID: 11976325.
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    171. Ramirez-Dominguez ME, Olamendi-Portugal T, Garcia U, Garcia C, Arechiga H, Possani LD. Cn11, the first example of a scorpion toxin that is a true blocker of Na(+) currents in crayfish neurons. J Exp Biol. 2002 Mar; 205(Pt 6):869-76. PMID: 11914394.
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    172. Pardo-Lopez L, Zhang M, Liu J, Jiang M, Possani LD, Tseng GN. Mapping the binding site of a human ether-a-go-go-related gene-specific peptide toxin (ErgTx) to the channel's outer vestibule. J Biol Chem. 2002 May 10; 277(19):16403-11. PMID: 11864985.
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    173. Pardo-López L, García-Valdés J, Gurrola GB, Robertson GA, Possani LD. Mapping the receptor site for ergtoxin, a specific blocker of ERG channels. FEBS Lett. 2002 Jan 02; 510(1-2):45-9. PMID: 11755529.
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    174. Corona M, Valdez-Cruz NA, Merino E, Zurita M, Possani LD. Genes and peptides from the scorpion Centruroides sculpturatus Ewing, that recognize Na(+)-channels. Toxicon. 2001 Dec; 39(12):1893-8. PMID: 11600153.
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    175. Goudet C, Ferrer T, Galàn L, Artiles A, Batista CF, Possani LD, Alvarez J, Aneiros A, Tytgat J. Characterization of two Bunodosoma granulifera toxins active on cardiac sodium channels. Br J Pharmacol. 2001 Nov; 134(6):1195-206. PMID: 11704639; PMCID: PMC1573052.
    176. Garcia-Valdes J, Zamudio FZ, Toro L, Possani LD, Possan LD. Slotoxin, alphaKTx1.11, a new scorpion peptide blocker of MaxiK channels that differentiates between alpha and alpha+beta (beta1 or beta4) complexes. FEBS Lett. 2001 Sep 21; 505(3):369-73. PMID: 11576530.
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    177. Rocchetti M, Besana A, Gurrola GB, Possani LD, Zaza A. Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential. J Physiol. 2001 Aug 01; 534(Pt 3):721-32. PMID: 11483703; PMCID: PMC2278748.
    178. Nishigaki T, Zamudio FZ, Possani LD, Darszon A. Time-resolved sperm responses to an egg peptide measured by stopped-flow fluorometry. Biochem Biophys Res Commun. 2001 Jun 08; 284(2):531-5. PMID: 11394914.
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    179. Frau A, Pisciotta M, Gurrola GB, Possani LD, Prestipino G. Synthetic undecapeptide (NTX10-20) of noxiustoxin blocks completely the I(A) potassium currents of cerebellum granular cells. Eur Biophys J. 2001; 29(8):569-73. PMID: 11288831.
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    180. Péter M, Varga Z, Hajdu P, Gáspár R, Damjanovich S, Horjales E, Possani LD, Panyi G. Effects of toxins Pi2 and Pi3 on human T lymphocyte Kv1.3 channels: the role of Glu7 and Lys24. J Membr Biol. 2001 Jan 01; 179(1):13-25. PMID: 11155206.
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    181. Batista CV, Gómez-Lagunas F, Lucas S, Possani LD. Tc1, from Tityus cambridgei, is the first member of a new subfamily of scorpion toxin that blocks K(+)-channels. FEBS Lett. 2000 Dec 08; 486(2):117-20. PMID: 11113450.
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    182. Péter M, Hajdu P, Varga Z, Damjanovich S, Possani LD, Panyi G, Gáspár R. Blockage of human T lymphocyte Kv1.3 channels by Pi1, a novel class of scorpion toxin. Biochem Biophys Res Commun. 2000 Nov 11; 278(1):34-7. PMID: 11071851.
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    183. Pisciotta M, Coronas FI, Bloch C, Prestipino G, Possani LD. Fast K(+) currents from cerebellum granular cells are completely blocked by a peptide purified from Androctonus australis Garzoni scorpion venom. Biochim Biophys Acta. 2000 Sep 29; 1468(1-2):203-12. PMID: 11018665.
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    184. Possani LD, Merino E, Corona M, Bolivar F, Becerril B. Peptides and genes coding for scorpion toxins that affect ion-channels. Biochimie. 2000 Sep-Oct; 82(9-10):861-8. PMID: 11086216.
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    185. Scaloni A, Bottiglieri C, Ferrara L, Corona M, Gurrola GB, Batista C, Wanke E, Possani LD. Disulfide bridges of ergtoxin, a member of a new sub-family of peptide blockers of the ether-a-go-go-related K+ channel. FEBS Lett. 2000 Aug 18; 479(3):156-7. PMID: 11023354.
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    186. Torres-Larios A, Gurrola GB, Zamudio FZ, Possani LD. Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus. Eur J Biochem. 2000 Aug; 267(16):5023-31. PMID: 10931184.
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    187. Conde R, Zamudio FZ, Rodríguez MH, Possani LD. Scorpine, an anti-malaria and anti-bacterial agent purified from scorpion venom. FEBS Lett. 2000 Apr 14; 471(2-3):165-8. PMID: 10767415.
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    188. Angulo Y, Olamendi-Portugal T, Possani LD, Lomonte B. Isolation and characterization of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a new Lys49 phospholipase A2 homologue. Int J Biochem Cell Biol. 2000 Jan; 32(1):63-71. PMID: 10661894.
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    189. Possani LD. Antivenom for scorpion sting. Lancet. 2000 Jan 01; 355(9197):67; author reply 67-8. PMID: 10615911.
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    190. Delepierre M, Prochnicka-Chalufour A, Boisbouvier J, Possani LD. Pi7, an orphan peptide from the scorpion Pandinus imperator: a 1H-NMR analysis using a nano-NMR Probe. Biochemistry. 1999 Dec 21; 38(51):16756-65. PMID: 10606507.
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    191. Conde R, Zamudio FZ, Becerril B, Possani LD. Phospholipin, a novel heterodimeric phospholipase A2 from Pandinus imperator scp6pion venom. FEBS Lett. 1999 Nov 05; 460(3):447-50. PMID: 10556514.
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    192. Tytgat J, Chandy KG, Garcia ML, Gutman GA, Martin-Eauclaire MF, van der Walt JJ, Possani LD. A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies. Trends Pharmacol Sci. 1999 Nov; 20(11):444-7. PMID: 10542442.
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    193. Selisko B, Licea AF, Becerril B, Zamudio F, Possani LD, Horjales E. Antibody BCF2 against scorpion toxin Cn2 from Centuroides noxius Hoffmann: primary structure and three-dimensional model as free Fv fragment and complexed with its antigen. Proteins. 1999 Oct 01; 37(1):130-43. PMID: 10451557.
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    194. Calderon-Aranda ES, Selisko B, York EJ, Gurrola GB, Stewart JM, Possani LD. Mapping of an epitope recognized by a neutralizing monoclonal antibody specific to toxin Cn2 from the scorpion Centruroides noxius, using discontinuous synthetic peptides. Eur J Biochem. 1999 Sep; 264(3):746-55. PMID: 10491120.
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    195. Possani LD, Becerril B, Delepierre M, Tytgat J. Scorpion toxins specific for Na+-channels. Eur J Biochem. 1999 Sep; 264(2):287-300. PMID: 10491073.
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    196. D'Suze G, Zamudio F, Gómez-Lagunas F, Possani LD. A novel K+ channel blocking toxin from Tityus discrepans scorpion venom. FEBS Lett. 1999 Jul 30; 456(1):146-8. PMID: 10452547.
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    197. Calderón-Aranda ES, Rivière G, Choumet V, Possani LD, Bon C. Pharmacokinetics of the toxic fraction of Centruroides limpidus limpidus venom in experimentally envenomed rabbits and effects of immunotherapy with specific F(ab')2. Toxicon. 1999 May; 37(5):771-82. PMID: 10219988.
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    198. Gurrola GB, Rosati B, Rocchetti M, Pimienta G, Zaza A, Arcangeli A, Olivotto M, Possani LD, Wanke E. A toxin to nervous, cardiac, and endocrine ERG K+ channels isolated from Centruroides noxius scorpion venom. FASEB J. 1999 May; 13(8):953-62. PMID: 10224238.
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    199. Yamamoto H, Sejbal J, York E, Stewart JM, Possani LD, Kotovych G. An nmr conformational analysis of a synthetic peptide Cn2(1-15)NH2-S-S-acetyl-Cn2(52-66)NH2 from the New World Centruroides noxius 2 (Cn2) scorpion toxin: comparison of the structure with those of the Centruroides scorpion toxins. Biopolymers. 1999 Apr; 49(4):277-86. PMID: 10079767.
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    200. Pintar A, Possani LD, Delepierre M. Solution structure of toxin 2 from centruroides noxius Hoffmann, a beta-scorpion neurotoxin acting on sodium channels. J Mol Biol. 1999 Mar 26; 287(2):359-67. PMID: 10080898.
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    201. Altamirano MM, García C, Possani LD, Fersht AR. Oxidative refolding chromatography: folding of the scorpion toxin Cn5. Nat Biotechnol. 1999 Feb; 17(2):187-91. PMID: 10052357.
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    202. Ottolia M, Babini E, Gazzotti P, Possani LD, Prestipino G. Reconstitution of a voltage and calcium dependent potassium channel from rat cerebellum. Brain Res. 1999 Jan 09; 815(2):410-3. PMID: 9878856.
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    203. Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C. Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta. Peptides. 1999; 20(6):679-86. PMID: 10477123.
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    204. Tytgat J, Debont T, Rostoll K, Müller GJ, Verdonck F, Daenens P, van der Walt JJ, Possani LD. Purification and partial characterization of a 'short' insectotoxin-like peptide from the venom of the scorpion Parabuthus schlechteri. FEBS Lett. 1998 Dec 28; 441(3):387-91. PMID: 9891977.
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    205. Possani LD, Zurita M, Delepierre M, Hernández FH, Rodríguez MH. From noxiustoxin to Shiva-3, a peptide toxic to the sporogonic development of Plasmodium berghei. Toxicon. 1998 Nov; 36(11):1683-92. PMID: 9792185.
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    206. Delepierre M, Prochnicka-Chalufour A, Possani LD. 1H NMR structural analysis of novel potassium blocking toxins using a nano-NMR probe. Toxicon. 1998 Nov; 36(11):1599-608. PMID: 9792176.
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    207. Boisbouvier J, Prochnicka-Chalufour A, Nieto AR, Torres JA, Nanard N, Rodriguez MH, Possani LD, Delepierre M. Structural information on a cecropin-like synthetic peptide, Shiva-3 toxic to the sporogonic development of Plasmodium berghei. Eur J Biochem. 1998 Oct 01; 257(1):263-73. PMID: 9799128.
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    208. Martínez F, Muñoz-Garay C, Gurrola G, Darszon A, Possani LD, Becerril B. Site directed mutants of Noxiustoxin reveal specific interactions with potassium channels. FEBS Lett. 1998 Jun 16; 429(3):381-4. PMID: 9662453.
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    209. Selisko B, Garcia C, Becerril B, Gómez-Lagunas F, Garay C, Possani LD. Cobatoxins 1 and 2 from Centruroides noxius Hoffmann constitute a subfamily of potassium-channel-blocking scorpion toxins. Eur J Biochem. 1998 Jun 15; 254(3):468-79. PMID: 9688256.
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    210. Olamendi-Portugal T, Gómez-Lagunas F, Gurrola GB, Possani LD. Two similar peptides from the venom of the scorpion Pandinus imperator, one highly effective blocker and the other inactive on K+ channels. Toxicon. 1998 May; 36(5):759-70. PMID: 9655636.
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    211. Valdivia HH, Possani LD. Peptide toxins as probes of ryanodine receptor structure and function. Trends Cardiovasc Med. 1998 Apr; 8(3):111-8. PMID: 21235920.
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    212. Péter M, Varga Z, Panyi G, Bene L, Damjanovich S, Pieri C, Possani LD, Gáspár R. Pandinus imperator scorpion venom blocks voltage-gated K+ channels in human lymphocytes. Biochem Biophys Res Commun. 1998 Jan 26; 242(3):621-5. PMID: 9464266.
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    213. Pisciotta M, Ottolia M, Possani LD, Prestipino G. A novel toxin form the scorpion Androctonus australis blocks Shaker K+ channels expressed in Xenopus oocytes. Biochem Biophys Res Commun. 1998 Jan 14; 242(2):287-91. PMID: 9446786.
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    214. Pisciotta M, Coronas FI, Possani LD, Prestipino G. The Androctonus australis garzoni scorpion venom contains toxins that selectively affect voltage-dependent K(+)-channels in cerebellum granular cells. Eur Biophys J. 1998; 27(1):69-73. PMID: 9463891.
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    215. Higareda AE, Possani LD, Ramírez OT. The use of culture redox potential and oxygen uptake rate for assessing glucose and glutamine depletion in hybridoma cultures. Biotechnol Bioeng. 1997 Dec 05; 56(5):555-63. PMID: 18642276.
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    216. Ben Khalifa R, Stankiewicz M, Pelhate M, Serrano-Hernandez SE, Possani LD, Hinkel H, Mebs D. Action of babycurus-toxin 1 from the east African scorpion Babycurus centrurimorphus on the isolated cockroach giant axon. Toxicon. 1997 Jul; 35(7):1069-80. PMID: 9248005.
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    217. Becerril B, Marangoni S, Possani LD. Toxins and genes isolated from scorpions of the genus Tityus. Toxicon. 1997 Jun; 35(6):821-35. PMID: 9241777.
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    218. Zamudio FZ, Conde R, Arévalo C, Becerril B, Martin BM, Valdivia HH, Possani LD. The mechanism of inhibition of ryanodine receptor channels by imperatoxin I, a heterodimeric protein from the scorpion Pandinus imperator. J Biol Chem. 1997 May 02; 272(18):11886-94. PMID: 9115249.
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    219. Zamudio FZ, Gurrola GB, Arévalo C, Sreekumar R, Walker JW, Valdivia HH, Possani LD. Primary structure and synthesis of Imperatoxin A (IpTx(a)), a peptide activator of Ca2+ release channels/ryanodine receptors. FEBS Lett. 1997 Apr 01; 405(3):385-9. PMID: 9108323.
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    220. Delepierre M, Prochnicka-Chalufour A, Possani LD. A novel potassium channel blocking toxin from the scorpion Pandinus imperator: A 1H NMR analysis using a nano-NMR probe. Biochemistry. 1997 Mar 04; 36(9):2649-58. PMID: 9054572.
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    221. García C, Becerril B, Selisko B, Delepierre M, Possani LD. Isolation, characterization and comparison of a novel crustacean toxin with a mammalian toxin from the venom of the scorpion Centruroides noxius Hoffmann. Comp Biochem Physiol B Biochem Mol Biol. 1997 Mar; 116(3):315-22. PMID: 9114491.
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    222. Gómez-Lagunas F, Olamendi-Portugal T, Possani LD. Block of ShakerB K+ channels by Pi1, a novel class of scorpion toxin. FEBS Lett. 1997 Jan 03; 400(2):197-200. PMID: 9001397.
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    223. Selisko B, Garcia C, Becerril B, Delepierre M, Possani LD. An insect-specific toxin from Centruroides noxius Hoffmann. cDNA, primary structure, three-dimensional model and electrostatic surface potentials in comparison with other toxin variants. Eur J Biochem. 1996 Dec 01; 242(2):235-42. PMID: 8973638.
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    224. Martinez F, Becerril B, Gurrola GB, Martin BM, Possani LD. Synthesis and expression of the gene coding for noxiustoxin, a K+ channel-blocking peptide from the venom of the scorpion Centruroides noxius. Toxicon. 1996 Nov-Dec; 34(11-12):1413-9. PMID: 9027998.
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    225. Licea AF, Becerril B, Possani LD. Fab fragments of the monoclonal antibody BCF2 are capable of neutralizing the whole soluble venom from the scorpion Centruroides noxius Hoffmann. Toxicon. 1996 Aug; 34(8):843-7. PMID: 8875771.
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    226. Nieto AR, Gurrola GB, Vaca L, Possani LD. Noxiustoxin 2, a novel K+ channel blocking peptide from the venom of the scorpion Centruroides noxius Hoffmann. Toxicon. 1996 Aug; 34(8):913-22. PMID: 8875778.
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    227. Gómez-Lagunas F, Olamendi-Portugal T, Zamudio FZ, Possani LD. Two novel toxins from the venom of the scorpion Pandinus imperator show that the N-terminal amino acid sequence is important for their affinities towards Shaker B K+ channels. J Membr Biol. 1996 Jul; 152(1):49-56. PMID: 8660410.
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    228. Zamudio F, Wolf KM, Martin BM, Possani LD, Chiappinelli VA. Two novel alpha-neurotoxins isolated from the taipan snake, Oxyuranus scutellatus, exhibit reduced affinity for nicotinic acetylcholine receptors in brain and skeletal muscle. Biochemistry. 1996 Jun 18; 35(24):7910-6. PMID: 8672493.
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    229. Nobile M, Noceti F, Prestipino G, Possani LD. Helothermine, a lizard venom toxin, inhibits calcium current in cerebellar granules. Exp Brain Res. 1996 Jun; 110(1):15-20. PMID: 8817251.
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    230. D'Suze G, Corona F, Possani LD, Sevcik C. High performance liquid chromatography purification and amino acid sequence of toxins from the muscarinic fraction of Tityus discrepans scorpion venom. Toxicon. 1996 May; 34(5):591-8. PMID: 8783453.
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    231. Olamendi-Portugal T, Gómez-Lagunas F, Gurrola GB, Possani LD. A novel structural class of K+-channel blocking toxin from the scorpion Pandinus imperator. Biochem J. 1996 May 01; 315 ( Pt 3):977-81. PMID: 8645186; PMCID: PMC1217303.
    232. Vaca L, Licea A, Possani LD. Modulation of cell membrane potential in cultured vascular endothelium. Am J Physiol. 1996 Mar; 270(3 Pt 1):C819-24. PMID: 8638662.
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    233. Dehesa-Dávila M, Ramírez AN, Zamudio FZ, Gurrola-Briones G, Liévano A, Darszon A, Possani LD. Structural and functional comparison of toxins from the venom of the scorpions Centruroides infamatus infamatus, Centruroides limpidus limpidus and Centruroides noxius. Comp Biochem Physiol B Biochem Mol Biol. 1996 Feb; 113(2):331-9. PMID: 8653586.
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    234. Corona M, Zurita M, Possani LD, Becerril B. Cloning and characterization of the genomic region encoding toxin IV-5 from the scorpion Tityus serrulatus Lutz and Mello. Toxicon. 1996 Feb; 34(2):251-6. PMID: 8711758.
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    235. Becerril B, Corona M, Coronas FI, Zamudio F, Calderon-Aranda ES, Fletcher PL, Martin BM, Possani LD. Toxic peptides and genes encoding toxin gamma of the Brazilian scorpions Tityus bahiensis and Tityus stigmurus. Biochem J. 1996 Feb 01; 313 ( Pt 3):753-60. PMID: 8611151; PMCID: PMC1216974.
    236. Dauplais M, Gilquin B, Possani LD, Gurrola-Briones G, Roumestand C, Ménez A. Determination of the three-dimensional solution structure of noxiustoxin: analysis of structural differences with related short-chain scorpion toxins. Biochemistry. 1995 Dec 26; 34(51):16563-73. PMID: 8527429.
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    237. Noeske-Jungblut C, Haendler B, Donner P, Alagon A, Possani L, Schleuning WD. Triabin, a highly potent exosite inhibitor of thrombin. J Biol Chem. 1995 Dec 01; 270(48):28629-34. PMID: 7499380.
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    238. Gurrola GB, Possani LD. Structural and functional features of noxiustoxin: a K+ channel blocker. Biochem Mol Biol Int. 1995 Oct; 37(3):527-35. PMID: 8595393.
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    239. Trequattrini C, Zamudio FZ, Petris A, Prestipino G, Possani LD, Franciolini F. Tityus bahiensis toxin IV-5b selectively affects Na channel inactivation in chick dorsal root ganglion neurons. Comp Biochem Physiol A Physiol. 1995 Sep; 112(1):21-8. PMID: 7553331.
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    240. Noceti F, Ramírez AN, Possani LD, Prestipino G. Characterization of a voltage-dependent potassium channel in squid Schwann cells reconstituted in planar lipid bilayers. Glia. 1995 Sep; 15(1):33-42. PMID: 8847099.
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    241. Vazquez A, Tapia JV, Eliason WK, Martin BM, Lebreton F, Delepierre M, Possani LD, Becerril B. Cloning and characterization of the cDNAs encoding Na+ channel-specific toxins 1 and 2 of the scorpion Centruroides noxius Hoffmann. Toxicon. 1995 Sep; 33(9):1161-70. PMID: 8585086.
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    242. Calderon-Aranda ES, Olamendi-Portugal T, Possani LD. The use of synthetic peptides can be a misleading approach to generate vaccines against scorpion toxins. Vaccine. 1995 Sep; 13(13):1198-206. PMID: 8578804.
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    243. Drakopoulou E, Cotton J, Virelizier H, Bernardi E, Schoofs AR, Partiseti M, Choquet D, Gurrola G, Possani LD, Vita C. Chemical synthesis, structural and functional characterisation of noxiustoxin, a powerful blocker of lymphocyte voltage-dependent K+ channels. Biochem Biophys Res Commun. 1995 Aug 24; 213(3):901-7. PMID: 7654252.
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    244. Gáspár R, Bene L, Damjanovich S, Muñoz-Garay C, Calderon-Aranda ES, Possani LD. Beta-scorpion toxin 2 from Centruroides noxius blocks voltage-gated K+ channels in human lymphocytes. Biochem Biophys Res Commun. 1995 Aug 15; 213(2):419-23. PMID: 7646494.
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    245. Hérion P, Gurrola-Briones G, Del Rocío Sánchez M, Saavedra R, Possani LD. Monoclonal antibodies against noxiustoxin. Hybridoma. 1995 Jun; 14(3):247-51. PMID: 7590787.
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    246. Rodriguez MC, Zamudio F, Torres JA, Gonzalez-Ceron L, Possani LD, Rodriguez MH. Effect of a cecropin-like synthetic peptide (Shiva-3) on the sporogonic development of Plasmodium berghei. Exp Parasitol. 1995 Jun; 80(4):596-604. PMID: 7758540.
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    247. Valdivia HH, Martin BM, Ramírez AN, Fletcher PL, Possani LD. Isolation and pharmacological characterization of four novel Na+ channel-blocking toxins from the scorpion Centruroides noxius Hoffmann. J Biochem. 1994 Dec; 116(6):1383-91. PMID: 7706233.
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    248. Dehesa-Dávila M, Martin BM, Nobile M, Prestipino G, Possani LD. Isolation of a toxin from Centruroides infamatus infamatus Koch scorpion venom that modifies Na+ permeability on chick dorsal root ganglion cells. Toxicon. 1994 Dec; 32(12):1487-93. PMID: 7725317.
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    249. Martin BM, Ramirez AN, Gurrola GB, Nobile M, Prestipino G, Possani LD. Novel K(+)-channel-blocking toxins from the venom of the scorpion Centruroides limpidus limpidus Karsch. Biochem J. 1994 Nov 15; 304 ( Pt 1):51-6. PMID: 7998956; PMCID: PMC1137450.
    250. Fletcher MD, Possani LD, Fletcher PL. Morphological studies by light and electron microscopy of pancreatic acinar cells under the effect of Tityus serrulatus venom. Cell Tissue Res. 1994 Nov; 278(2):255-64. PMID: 8001082.
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    251. Lebreton F, Delepierre M, Ramírez AN, Balderas C, Possani LD. Primary and NMR three-dimensional structure determination of a novel crustacean toxin from the venom of the scorpion Centruroides limpidus limpidus Karsch. Biochemistry. 1994 Sep 20; 33(37):11135-49. PMID: 7727365.
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    252. Dehesa-Dávila M, Possani LD. Scorpionism and serotherapy in Mexico. Toxicon. 1994 Sep; 32(9):1015-8. PMID: 7801335.
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    253. Gurrola GB, Moreno-Hagelsieb G, Zamudio FZ, García M, Soberon X, Possani LD. The disulfide bridges of toxin 2 from the scorpion Centruroides noxius Hoffmann and its three-dimensional structure calculated using the coordinates of variant 3 from Centruroides sculpturatus. FEBS Lett. 1994 Jun 20; 347(1):59-62. PMID: 8013663.
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    254. Sacile R, Ruggiero C, Ballestrero R, Possani LD, Prestipino G, Rauch G. Secondary structure of noxiustoxin and charybdotoxin from hydropathy power spectra. Biochem Biophys Res Commun. 1994 May 30; 201(1):186-93. PMID: 7515231.
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    255. Ramírez AN, Martin BM, Gurrola GB, Possani LD. Isolation and characterization of a novel toxin from the venom of the scorpion Centruroides limpidus limpidus Karsch. Toxicon. 1994 Apr; 32(4):479-90. PMID: 8053002.
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    256. Nobile M, Magnelli V, Lagostena L, Mochca-Morales J, Possani LD, Prestipino G. The toxin helothermine affects potassium currents in newborn rat cerebellar granule cells. J Membr Biol. 1994 Apr; 139(1):49-55. PMID: 8071987.
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    257. Noeske-Jungblut C, Krätzschmar J, Haendler B, Alagon A, Possani L, Verhallen P, Donner P, Schleuning WD. An inhibitor of collagen-induced platelet aggregation from the saliva of Triatoma pallidipennis. J Biol Chem. 1994 Feb 18; 269(7):5050-3. PMID: 8106481.
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    258. Higareda AE, Possani LD, Ramírez OT. Metabolic and kinetic studies of hybridomas in exponentially fed-batch cultures using T-flasks. Cytotechnology. 1994; 15(1-3):73-86. PMID: 7765955.
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    259. Becerril B, Corona M, Mejía MC, Martin BM, Lucas S, Bolivar F, Possani LD. The genomic region encoding toxin gamma from the scorpion Tityus serrulatus contains an intron. FEBS Lett. 1993 Nov 29; 335(1):6-8. PMID: 8243666.
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    260. Becerril B, Vázquez A, García C, Corona M, Bolivar F, Possani LD. Cloning and characterization of cDNAs that code for Na(+)-channel-blocking toxins of the scorpion Centruroides noxius Hoffmann. Gene. 1993 Jun 30; 128(2):165-71. PMID: 8390386.
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    261. Vaca L, Gurrola GB, Possani LD, Kunze DL. Blockade of a KCa channel with synthetic peptides from noxiustoxin: a K+ channel blocker. J Membr Biol. 1993 Jun; 134(2):123-9. PMID: 8411115.
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    262. Vázquez A, Becerril B, Martin BM, Zamudio F, Bolívar F, Possani LD. Primary structure determination and cloning of the cDNA encoding toxin 4 of the scorpion Centruroides noxius Hoffmann. FEBS Lett. 1993 Mar 29; 320(1):43-6. PMID: 8462674.
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    263. Calderon-Aranda ES, Hozbor D, Possani LD. Neutralizing capacity of murine sera induced by different antigens of scorpion venom. Toxicon. 1993 Mar; 31(3):327-37. PMID: 8470136.
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    264. Harvey AL, Marshall DL, Possani LD. Dendrotoxin-like effects of noxiustoxin. Toxicon. 1992 Nov; 30(11):1497-500. PMID: 1485346.
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    265. Possani LD, Martin BM, Yatani A, Mochca-Morales J, Zamudio FZ, Gurrola GB, Brown AM. Isolation and physiological characterization of taicatoxin, a complex toxin with specific effects on calcium channels. Toxicon. 1992 Nov; 30(11):1343-64. PMID: 1485334.
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    266. Valdivia HH, Martin BM, Escobar L, Possani LD. Noxiustoxin and leiurutoxin III, two homologous peptide toxins with binding properties to synaptosomal membrane K+ channels. Biochem Int. 1992 Sep; 27(6):953-62. PMID: 1280139.
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    267. Fletcher PL, Fletcher MD, Possani LD. Characteristics of pancreatic exocrine secretion produced by venom from the Brazilian scorpion, Tityus serrulatus. Eur J Cell Biol. 1992 Aug; 58(2):259-70. PMID: 1385124.
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    268. Possani LD, Mochca-Morales J, Amezcua J, Martin BM, Prestipino G, Nobile M. Anionic currents of chick sensory neurons are affected by a phospholipase A2 purified from the venom of the taipan snake. Biochim Biophys Acta. 1992 Apr 07; 1134(3):210-6. PMID: 1373076.
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    269. Estrada IC, Gutiérrez MC, Esparza J, Quesada-Pascual F, Estrada-Parra S, Possani LD. Use of synthetic peptides corresponding to sequences of Mycobacterium leprae proteins to study delayed-type hypersensitivity response in sensitized guinea pigs. Int J Lepr Other Mycobact Dis. 1992 Mar; 60(1):18-27. PMID: 1602190.
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    270. Zamudio F, Saavedra R, Martin BM, Gurrola-Briones G, Hérion P, Possani LD. Amino acid sequence and immunological characterization with monoclonal antibodies of two toxins from the venom of the scorpion Centruroides noxius Hoffmann. Eur J Biochem. 1992 Feb 15; 204(1):281-92. PMID: 1371253.
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    271. Possani LD, Martin BM, Fletcher MD, Fletcher PL. Discharge effect on pancreatic exocrine secretion produced by toxins purified from Tityus serrulatus scorpion venom. J Biol Chem. 1991 Feb 15; 266(5):3178-85. PMID: 1993690.
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    272. Colden-Stanfield M, Schilling WP, Possani LD, Kunze DL. Bradykinin-induced potassium current in cultured bovine aortic endothelial cells. J Membr Biol. 1990 Jul; 116(3):227-38. PMID: 2388254.
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    273. Ramírez GA, Fletcher PL, Possani LD. Characterization of the venom from Crotalus molossus nigrescens Gloyd (black tail rattlesnake): isolation of two proteases. Toxicon. 1990; 28(3):285-97. PMID: 2188398.
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    274. Mochca-Morales J, Martin BM, Possani LD. Isolation and characterization of helothermine, a novel toxin from Heloderma horridum horridum (Mexican beaded lizard) venom. Toxicon. 1990; 28(3):299-309. PMID: 1693019.
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    275. Prestipino G, Valdivia HH, Liévano A, Darszon A, Ramírez AN, Possani LD. Purification and reconstitution of potassium channel proteins from squid axon membranes. FEBS Lett. 1989 Jul 03; 250(2):570-4. PMID: 2753152.
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    276. Gurrola GB, Molinar-Rode R, Sitges M, Bayon A, Possani LD. Synthetic peptides corresponding to the sequence of noxiustoxin indicate that the active site of this K+ channel blocker is located on its amino-terminal portion. J Neural Transm. 1989; 77(1):11-20. PMID: 2746197.
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    277. Kirsch GE, Skattebøl A, Possani LD, Brown AM. Modification of Na channel gating by an alpha scorpion toxin from Tityus serrulatus. J Gen Physiol. 1989 Jan; 93(1):67-83. PMID: 2536799; PMCID: PMC2216202.
    278. Yatani A, Kirsch GE, Possani LD, Brown AM. Effects of New World scorpion toxins on single-channel and whole cell cardiac sodium currents. Am J Physiol. 1988 Mar; 254(3 Pt 2):H443-51. PMID: 2450477.
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    279. Valdivia HH, Smith JS, Martin BM, Coronado R, Possani LD. Charybdotoxin and noxiustoxin, two homologous peptide inhibitors of the K+ (Ca2+) channel. FEBS Lett. 1988 Jan 04; 226(2):280-4. PMID: 2448164.
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    280. Ramírez AN, Gurrola GB, Martin BM, Possani LD. Isolation of several toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann. Toxicon. 1988; 26(9):773-83. PMID: 3201484.
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    281. Alagón AC, Guzmán HS, Martin BM, Ramírez AN, Carbone E, Possani LD. Isolation and characterization of two toxins from the Mexican scorpion Centruroides limpidus limpidus Karsch. Comp Biochem Physiol B. 1988; 89(1):153-61. PMID: 2451580.
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    282. Martin BM, Carbone E, Yatani A, Brown AM, Ramírez AN, Gurrola GB, Possani LD. Amino acid sequence and physiological characterization of toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann. Toxicon. 1988; 26(9):785-94. PMID: 2849217.
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    283. Brown AM, Yatani A, Lacerda AE, Gurrola GB, Possani LD. Neurotoxins that act selectively on voltage-dependent cardiac calcium channels. Circ Res. 1987 Oct; 61(4 Pt 2):I6-9. PMID: 2443275.
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    284. Sitges M, Possani LD, Bayón A. Characterization of the actions of toxins II-9.2.2 and II-10 from the venom of the scorpion Centruroides noxius on transmitter release from mouse brain synaptosomes. J Neurochem. 1987 Jun; 48(6):1745-52. PMID: 2437248.
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    285. Carbone E, Prestipino G, Spadavecchia L, Franciolini F, Possani LD. Blocking of the squid axon K+ channel by noxiustoxin: a toxin from the venom of the scorpion Centruroides noxius. Pflugers Arch. 1987 May; 408(5):423-31. PMID: 2439979.
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    286. Alagon A, Possani LD, Smart J, Schleuning WD. Helodermatine, a kallikrein-like, hypotensive enzyme from the venom of Heloderma horridum horridum (Mexican beaded lizard). J Exp Med. 1986 Dec 01; 164(6):1835-45. PMID: 3537191; PMCID: PMC2188495.
    287. Sitges M, Possani LD, Bayón A. Noxiustoxin, a short-chain toxin from the Mexican scorpion Centruroides noxius, induces transmitter release by blocking K+ permeability. J Neurosci. 1986 Jun; 6(6):1570-4. PMID: 3012016.
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    288. Sosa BP, Alagón AC, Martin BM, Possani LD. Biochemical characterization of the phospholipase A2 purified from the venom of the Mexican beaded lizard (Heloderma horridum horridum Wiegmann). Biochemistry. 1986 May 20; 25(10):2927-33. PMID: 3087412.
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    289. Possani LD, Martin BM, Svendsen I, Rode GS, Erickson BW. Scorpion toxins from Centruroides noxius and Tityus serrulatus. Primary structures and sequence comparison by metric analysis. Biochem J. 1985 Aug 01; 229(3):739-50. PMID: 4052021; PMCID: PMC1145119.
    290. Carbone E, Prestipino G, Franciolini F, Dent MA, Possani LD. Selective modification of the squid axon Na currents by Centruroides noxius toxin II-10. J Physiol (Paris). 1984; 79(4):179-84. PMID: 6099409.
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    291. Trejo AC, Possani LD. Electron microscopic evidence for scorpion toxin binding to synapses of rat brain cortex. Neurosci Lett. 1982 Oct 08; 32(2):103-8. PMID: 7145231.
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    292. Carbone E, Wanke E, Prestipino G, Possani LD, Maelicke A. Selective blockage of voltage-dependent K+ channels by a novel scorpion toxin. Nature. 1982 Mar 04; 296(5852):90-1. PMID: 6278313.
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    293. Alagón AC, Maldonado ME, Juliá JZ, Sánchez CR, Possani LD. Venom from two sub-species of Heloderma horridum (Mexican beaded lizard): general characterization and purification of N-benzoyl-L-arginine ethyl ester hydrolase. Toxicon. 1982; 20(2):463-75. PMID: 7080053.
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    294. Possani L, Steinmetz WE, Dent MA, Alagón AC, Wüthrich K. Preliminary spectroscopic characterization of six toxins from Latin American scorpions. Biochim Biophys Acta. 1981 Jul 28; 669(2):183-92. PMID: 7284435.
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    295. Pérez de la Mora M, Possani LD, Tapia R, Teran L, Palacios R, Fuxe K, Hökfelt T, Ljungdahl A. Demonstration of central gamma-aminobutyrate-containing nerve terminals by means of antibodies against glutamate decarboxylase. Neuroscience. 1981; 6(5):875-95. PMID: 6787456.
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    296. Possani LD, Fernández de Castro J, Juliá JZ. Detoxification with glutaraldehyde of purified scorpion (Centruroides noxius Hoffmann) venom. Toxicon. 1981; 19(2):323-9. PMID: 6791311.
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    297. Alagón AC, Molinar RR, Possani LD, Fletcher PL, Cronan JE, Julia JZ. Venom from the snake Bothrops asper Garman. Purification and characterization of three phospholipases A2. Biochem J. 1980 Mar 01; 185(3):695-704. PMID: 7387631; PMCID: PMC1161447.
    298. Possani LD, Fletcher PL, Alagón AB, Alagón AC, Juliá JZ. Purification and characterization of a mammalian toxin from venom of the Mexican scorpion, Centruroides limpidus tecomanus Hoffmann. Toxicon. 1980; 18(2):175-83. PMID: 7394806.
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    299. Possani LD, Sosa BP, Alagón AC, Burchfield PM. The venom from the snakes Agkistrodon bilineatus Taylori and Crotalus durissus Totonacus: lethality, biochemical and immunological properties. Toxicon. 1980; 18(3):356-60. PMID: 6771890.
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    300. Dent MA, Possani LD, Ramírez GA, Fletcher PL. Purification and characterization of two mammalian toxins from the venom of the Mexican scorpion Centruroides noxius Hoffmann. Toxicon. 1980; 18(3):343-50. PMID: 7394823.
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    301. Possani LD, Alagòn AC, Fletcher PL, Varela MJ, Juliá JZ. Purification and characterization of a phospholipase A2 from the venom of the coral snake, Micrurus fulvius microgalbineus (Brown and Smith). Biochem J. 1979 Jun 01; 179(3):603-6. PMID: 475771; PMCID: PMC1186669.
    302. Sosa BP, Alagón AC, Possani LD, Juliá JZ. Comparison of phospholipase activity with direct and indirect lytic effects of animal venoms upon human red cells. Comp Biochem Physiol B. 1979; 64(2):231-4. PMID: 318305.
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    303. Possani LD, Ramírez GA, Fletcher PL, Gurrola MA. Isolation of two mammalian toxins from the venom of the Mexican scorpion Centruroides elegans (Thorell). FEBS Lett. 1978 Jul 15; 91(2):261-4. PMID: 680131.
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    304. Bayón A, Possani LD, Rode G, Tapia R. Kinetics of brain glutamate decarboxylase. Dead-end and product inhibition studies. J Neurochem. 1978 Jun; 30(6):1629-31. PMID: 671008.
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    305. Hökfelt T, Elde R, Fuxe K, Johansson O, Ljungdahl A, Goldstein M, Luft R, Efendic S, Nilsson G, Terenius L, Ganten D, Jeffcoate SL, Rehfeld J, Said S, Perez de la Mora M, Possani L, Tapia R, Teran L, Palacios R. Aminergic and peptidergic pathways in the nervous system with special reference to the hypothalamus. Res Publ Assoc Res Nerv Ment Dis. 1978; 56:69-135. PMID: 23576.
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    306. Bayón A, Possani LD, Tapia M, Tapia R. Kinetics of brain glutamate decarboxylase. Interactions with glutamate, pyridoxal 5'-phosphate and glutamate-pyridoxal 5'-phosphate Schiff base. J Neurochem. 1977 Sep; 29(3):519-25. PMID: 894307.
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    307. Bayón A, Possani LD, Tapia R. Kinetics of brain glutamate decarboxylase. Inhibition studies with N-(5'-phosphopyridoxyl) amino acids. J Neurochem. 1977 Sep; 29(3):513-7. PMID: 894306.
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    308. Possani LD, Alagón AC, Fletcher PL, Erickson BW. Purification and properties of mammalian toxins from the venom of Brazilian Scorpion Tityus serrulatus Lutz and Mello. Arch Biochem Biophys. 1977 Apr 30; 180(2):394-403. PMID: 879793.
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    309. Possani LD, Bayón A, Tapia R. Synthesis of affinity chromatography resins for the purification of brain glutamate decarboxylase. Neurochem Res. 1977 Feb; 2(1):51-7. PMID: 24271849.
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    310. Klett RP, Fulpius BW, Cooper D, Smith M, Reich E, Possani LD. The acetylcholine receptor. I. Purification and characterization of a macromolecule isolated from Electrophorus electricus. J Biol Chem. 1973 Oct 10; 248(19):6841-53. PMID: 4745446.
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    311. Possani LD. GABA effects and GABA receptors in neuromuscular junctions of crustaceans: analysis of some stereochemical models. Rev Bras Pesqui Med Biol. 1973 Jan-Apr; 6(1):31-42. PMID: 4724468.
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    312. Tondo CV, Possani LD. Study of the bimodal frequency distribution of the relative concentration of hemoglobin S in heterozygous carriers. Rev Bras Pesqui Med Biol. 1972 Jan-Apr; 5(1-2):47-56. PMID: 4680454.
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    313. Possani LD, Banerjee R, Balny C, Douzou P. Oxidation of haemoglobin by oxygen in light: possible role of singlet oxygen. Nature. 1970 May 30; 226(5248):861-2. PMID: 5444631.
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