Header Logo
Last Name

Professor Pradipsinh Rathod

Title[no position]
Institution[no institution name]
Address[no address]
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Balabaskaran Nina P, Mohanty AK, Ballav S, Vernekar S, Bhinge S, D'souza M, Walke J, Manoharan SK, Mascarenhas A, Gomes E, Chery L, Valecha N, Kumar A, Rathod PK. Dynamics of Plasmodium vivax sporogony in wild Anopheles stephensi in a malaria-endemic region of Western India. Malar J. 2017 Jul 11; 16(1):284. PMID: 28693607.
      View in: PubMed
    2. Chery L, Maki JN, Mascarenhas A, Walke JT, Gawas P, Almeida A, Fernandes M, Vaz M, Ramanan R, Shirodkar D, Bernabeu M, Manoharan SK, Pereira L, Dash R, Sharma A, Shaik RB, Chakrabarti R, Babar P, White J, Mudeppa DG, Kumar S, Zuo W, Skillman KM, Kanjee U, Lim C, Shaw-Saliba K, Kumar A, Valecha N, Jindal VN, Khandeparkar A, Naik P, Amonkar S, Duraisingh MT, Tuljapurkar S, Smith JD, Dubhashi N, Pinto RG, Silveria M, Gomes E, Rathod PK. Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India. Malar J. 2016 11 25; 15(1):569. PMID: 27884146.
      View in: PubMed
    3. Kumar S, Mudeppa DG, Sharma A, Mascarenhas A, Dash R, Pereira L, Shaik RB, Maki JN, White J, Zuo W, Tuljapurkar S, Duraisingh MT, Gomes E, Chery L, Rathod PK. Distinct genomic architecture of Plasmodium falciparum populations from South Asia. Mol Biochem Parasitol. 2016 Nov - Dec; 210(1-2):1-4. PMID: 27457272.
      View in: PubMed
    4. Kumar A, Hosmani R, Jadhav S, de Sousa T, Mohanty A, Naik M, Shettigar A, Kale S, Valecha N, Chery L, Rathod PK. Anopheles subpictus carry human malaria parasites in an urban area of Western India and may facilitate perennial malaria transmission. Malar J. 2016 Feb 27; 15:124. PMID: 26919828; PMCID: PMC4769513.
    5. White J, Mascarenhas A, Pereira L, Dash R, Walke JT, Gawas P, Sharma A, Manoharan SK, Guler JL, Maki JN, Kumar A, Mahanta J, Valecha N, Dubhashi N, Vaz M, Gomes E, Chery L, Rathod PK. In vitro adaptation of Plasmodium falciparum reveal variations in cultivability. Malar J. 2016 Jan 22; 15:33. PMID: 26794408; PMCID: PMC4722725.
    6. Wassmer SC, Taylor TE, Rathod PK, Mishra SK, Mohanty S, Arevalo-Herrera M, Duraisingh MT, Smith JD. Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach. Am J Trop Med Hyg. 2015 Sep; 93(3 Suppl):42-56. PMID: 26259939; PMCID: PMC4574273.
    7. Cui L, Mharakurwa S, Ndiaye D, Rathod PK, Rosenthal PJ. Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network. Am J Trop Med Hyg. 2015 Sep; 93(3 Suppl):57-68. PMID: 26259943; PMCID: PMC4574275.
    8. Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S, Tomchick DR, Deng X, Laird T, Bhatia SN, March S, Ng CL, Fidock DA, Wittlin S, Lafuente-Monasterio M, Benito FJ, Alonso LM, Martinez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Haselden JN, Louttit J, Cui Y, Sridhar A, Zeeman AM, Kocken C, Sauerwein R, Dechering K, Avery VM, Duffy S, Delves M, Sinden R, Ruecker A, Wickham KS, Rochford R, Gahagen J, Iyer L, Riccio E, Mirsalis J, Bathhurst I, Rueckle T, Ding X, Campo B, Leroy D, Rogers MJ, Rathod PK, Burrows JN, Charman SA. A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med. 2015 Jul 15; 7(296):296ra111. PMID: 26180101; PMCID: PMC4539048.
    9. Mudeppa DG, Kumar S, Kokkonda S, White J, Rathod PK. Topoisomerase II from Human Malaria Parasites: EXPRESSION, PURIFICATION, AND SELECTIVE INHIBITION. J Biol Chem. 2015 Aug 14; 290(33):20313-24. PMID: 26055707; PMCID: PMC4536438.
    10. Deng X, Matthews D, Rathod PK, Phillips MA. The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions. Acta Crystallogr F Struct Biol Commun. 2015 May; 71(Pt 5):553-9. PMID: 25945708; PMCID: PMC4427164.
    11. Kumar S, Krishnamoorthy K, Mudeppa DG, Rathod PK. Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein-protein interactions. Acta Crystallogr F Struct Biol Commun. 2015 May; 71(Pt 5):600-8. PMID: 25945715; PMCID: PMC4427171.
    12. Guler JL, White J, Phillips MA, Rathod PK. Atovaquone tolerance in Plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor. Antimicrob Agents Chemother. 2015 Jan; 59(1):686-9. PMID: 25331708; PMCID: PMC4291421.
    13. Deng X, Kokkonda S, El Mazouni F, White J, Burrows JN, Kaminsky W, Charman SA, Matthews D, Rathod PK, Phillips MA. Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors. J Med Chem. 2014 Jun 26; 57(12):5381-94. PMID: 24801997; PMCID: PMC4079327.
    14. Mudeppa DG, Rathod PK. Expression of functional Plasmodium falciparum enzymes using a wheat germ cell-free system. Eukaryot Cell. 2013 Dec; 12(12):1653-63. PMID: 24123271; PMCID: PMC3889570.
    15. Mailu BM, Ramasamay G, Mudeppa DG, Li L, Lindner SE, Peterson MJ, DeRocher AE, Kappe SH, Rathod PK, Gardner MJ. A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway. J Biol Chem. 2013 Nov 08; 288(45):32539-52. PMID: 24072705; PMCID: PMC3820887.
    16. Herricks T, Avril M, Janes J, Smith JD, Rathod PK. Clonal variants of Plasmodium falciparum exhibit a narrow range of rolling velocities to host receptor CD36 under dynamic flow conditions. Eukaryot Cell. 2013 Nov; 12(11):1490-8. PMID: 24014767; PMCID: PMC3837943.
    17. Guler JL, Freeman DL, Ahyong V, Patrapuvich R, White J, Gujjar R, Phillips MA, DeRisi J, Rathod PK. Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications. PLoS Pathog. 2013; 9(5):e1003375. PMID: 23717205; PMCID: PMC3662640.
    18. Herricks T, Seydel KB, Molyneux M, Taylor T, Rathod PK. Estimating physical splenic filtration of Plasmodium falciparum-infected red blood cells in malaria patients. Cell Microbiol. 2012 Dec; 14(12):1880-91. PMID: 22892025; PMCID: PMC3501548.
    19. Marwaha A, White J, El Mazouni F, Creason SA, Kokkonda S, Buckner FS, Charman SA, Phillips MA, Rathod PK. Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase. J Med Chem. 2012 Sep 13; 55(17):7425-36. PMID: 22877245; PMCID: PMC3446820.
    20. Narayanasamy K, Chery L, Basu A, Duraisingh MT, Escalante A, Fowble J, Guler JL, Herricks T, Kumar A, Majumder P, Maki J, Mascarenhas A, Rodrigues J, Roy B, Sen S, Shastri J, Smith J, Valecha N, White J, Rathod PK. Malaria evolution in South Asia: knowledge for control and elimination. Acta Trop. 2012 Mar; 121(3):256-66. PMID: 22266213; PMCID: PMC3894252.
    21. Kumar A, Chery L, Biswas C, Dubhashi N, Dutta P, Dua VK, Kacchap M, Kakati S, Khandeparkar A, Kour D, Mahajan SN, Maji A, Majumder P, Mohanta J, Mohapatra PK, Narayanasamy K, Roy K, Shastri J, Valecha N, Vikash R, Wani R, White J, Rathod PK. Malaria in South Asia: prevalence and control. Acta Trop. 2012 Mar; 121(3):246-55. PMID: 22248528; PMCID: PMC3808995.
    22. Coteron JM, Marco M, Esquivias J, Deng X, White KL, White J, Koltun M, El Mazouni F, Kokkonda S, Katneni K, Bhamidipati R, Shackleford DM, Angulo-Barturen I, Ferrer SB, Jiménez-Díaz MB, Gamo FJ, Goldsmith EJ, Charman WN, Bathurst I, Floyd D, Matthews D, Burrows JN, Rathod PK, Charman SA, Phillips MA. Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. J Med Chem. 2011 Aug 11; 54(15):5540-61. PMID: 21696174; PMCID: PMC3156099.
    23. Herricks T, Seydel KB, Turner G, Molyneux M, Heyderman R, Taylor T, Rathod PK. A microfluidic system to study cytoadhesion of Plasmodium falciparum infected erythrocytes to primary brain microvascularendothelial cells. Lab Chip. 2011 Sep 07; 11(17):2994-3000. PMID: 21743938; PMCID: PMC3809019.
    24. Gujjar R, El Mazouni F, White KL, White J, Creason S, Shackleford DM, Deng X, Charman WN, Bathurst I, Burrows J, Floyd DM, Matthews D, Buckner FS, Charman SA, Phillips MA, Rathod PK. Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice. J Med Chem. 2011 Jun 09; 54(11):3935-49. PMID: 21517059; PMCID: PMC3124361.
    25. Kumar A, Dua VK, Rathod PK. Malaria-attributed death rates in India. Lancet. 2011 Mar 19; 377(9770):991-2; author reply 994-5. PMID: 21420546; PMCID: PMC3883669.
    26. Ganesan SM, Morrisey JM, Ke H, Painter HJ, Laroiya K, Phillips MA, Rathod PK, Mather MW, Vaidya AB. Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection. Mol Biochem Parasitol. 2011 May; 177(1):29-34. PMID: 21251930; PMCID: PMC3057331.
    27. Essaka DC, White J, Rathod P, Whitmore CD, Hindsgaul O, Palcic MM, Dovichi NJ. Monitoring the uptake of glycosphingolipids in Plasmodium falciparum-infected erythrocytes using both fluorescence microscopy and capillary electrophoresis with laser-induced fluorescence detection. Anal Chem. 2010 Dec 01; 82(23):9955-8. PMID: 21043509; PMCID: PMC2995841.
    28. Phillips MA, Rathod PK. Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy. Infect Disord Drug Targets. 2010 Jun; 10(3):226-39. PMID: 20334617; PMCID: PMC2883174.
    29. Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley PL, Castro S, Angulo-Barturen I, Ferrer S, Rosenthal PJ, Derisi JL, Sullivan DJ, Lazo JS, Roos DS, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM, Guy RK. Chemical genetics of Plasmodium falciparum. Nature. 2010 May 20; 465(7296):311-5. PMID: 20485428; PMCID: PMC2874979.
    30. Sun XE, Sharling L, Muthalagi M, Mudeppa DG, Pankiewicz KW, Felczak K, Rathod PK, Mead J, Striepen B, Hedstrom L. Prodrug activation by Cryptosporidium thymidine kinase. J Biol Chem. 2010 May 21; 285(21):15916-22. PMID: 20231284; PMCID: PMC2871459.
    31. Larson ET, Mudeppa DG, Gillespie JR, Mueller N, Napuli AJ, Arif JA, Ross J, Arakaki TL, Lauricella A, Detitta G, Luft J, Zucker F, Verlinde CL, Fan E, Van Voorhis WC, Buckner FS, Rathod PK, Hol WG, Merritt EA. The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase. J Mol Biol. 2010 Mar 12; 396(5):1244-59. PMID: 20070944; PMCID: PMC2844865.
    32. Deng X, Gujjar R, El Mazouni F, Kaminsky W, Malmquist NA, Goldsmith EJ, Rathod PK, Phillips MA. Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds. J Biol Chem. 2009 Sep 25; 284(39):26999-7009. PMID: 19640844; PMCID: PMC2785385.
    33. Pang CK, Hunter JH, Gujjar R, Podutoori R, Bowman J, Mudeppa DG, Rathod PK. Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase. Mol Biochem Parasitol. 2009 Nov; 168(1):74-83. PMID: 19591883; PMCID: PMC2741015.
    34. Herricks T, Antia M, Rathod PK. Deformability limits of Plasmodium falciparum-infected red blood cells. Cell Microbiol. 2009 Sep; 11(9):1340-53. PMID: 19438513; PMCID: PMC2774476.
    35. Gujjar R, Marwaha A, El Mazouni F, White J, White KL, Creason S, Shackleford DM, Baldwin J, Charman WN, Buckner FS, Charman S, Rathod PK, Phillips MA. Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice. J Med Chem. 2009 Apr 09; 52(7):1864-72. PMID: 19296651; PMCID: PMC2746568.
    36. Ganesan K, Ponmee N, Jiang L, Fowble JW, White J, Kamchonwongpaisan S, Yuthavong Y, Wilairat P, Rathod PK. A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates. PLoS Pathog. 2008 Nov; 4(11):e1000214. PMID: 19023412; PMCID: PMC2581438.
    37. Gonzales JM, Patel JJ, Ponmee N, Jiang L, Tan A, Maher SP, Wuchty S, Rathod PK, Ferdig MT. Regulatory hotspots in the malaria parasite genome dictate transcriptional variation. PLoS Biol. 2008 Sep 30; 6(9):e238. PMID: 18828674; PMCID: PMC2553844.
    38. Antia M, Herricks T, Rathod PK. Microfluidic approaches to malaria pathogenesis. Cell Microbiol. 2008 Oct; 10(10):1968-74. PMID: 18754851; PMCID: PMC3818003.
    39. Phillips MA, Gujjar R, Malmquist NA, White J, El Mazouni F, Baldwin J, Rathod PK. Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum. J Med Chem. 2008 Jun 26; 51(12):3649-53. PMID: 18522386; PMCID: PMC2624570.
    40. Hunter JH, Gujjar R, Pang CK, Rathod PK. Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX. PLoS One. 2008 May 21; 3(5):e2237. PMID: 18493582; PMCID: PMC2386288.
    41. Cui L, Miao J, Furuya T, Fan Q, Li X, Rathod PK, Su XZ, Cui L. Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development. Eukaryot Cell. 2008 Jul; 7(7):1200-10. PMID: 18487348; PMCID: PMC2446667.
    42. Mui EJ, Schiehser GA, Milhous WK, Hsu H, Roberts CW, Kirisits M, Muench S, Rice D, Dubey JP, Fowble JW, Rathod PK, Queener SF, Liu SR, Jacobus DP, McLeod R. Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo. PLoS Negl Trop Dis. 2008 Mar 05; 2(3):e190. PMID: 18320016; PMCID: PMC2254147.
    43. Malmquist NA, Gujjar R, Rathod PK, Phillips MA. Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase. Biochemistry. 2008 Feb 26; 47(8):2466-75. PMID: 18225919; PMCID: PMC2868338.
    44. Antia M, Herricks T, Rathod PK. Microfluidic modeling of cell-cell interactions in malaria pathogenesis. PLoS Pathog. 2007 Jul; 3(7):e99. PMID: 17658948; PMCID: PMC1924869.
    45. Eastman RT, White J, Hucke O, Yokoyama K, Verlinde CL, Hast MA, Beese LS, Gelb MH, Rathod PK, Van Voorhis WC. Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. Mol Biochem Parasitol. 2007 Mar; 152(1):66-71. PMID: 17208314; PMCID: PMC2875941.
    46. Mudeppa DG, Pang CK, Tsuboi T, Endo Y, Buckner FS, Varani G, Rathod PK. Cell-free production of functional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase. Mol Biochem Parasitol. 2007 Feb; 151(2):216-9. PMID: 17157934.
      View in: PubMed
    47. Pang CK, De SK, White J, Buckner FS, Varani G, Rathod PK. Differential drug binding by the highly conserved Plasmodium falciparum thymidylate synthase. Mol Biochem Parasitol. 2005 Sep; 143(1):121-4. PMID: 15978681.
      View in: PubMed
    48. Baldwin J, Michnoff CH, Malmquist NA, White J, Roth MG, Rathod PK, Phillips MA. High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem. 2005 Jun 10; 280(23):21847-53. PMID: 15795226.
      View in: PubMed
    49. Eastman RT, White J, Hucke O, Bauer K, Yokoyama K, Nallan L, Chakrabarti D, Verlinde CL, Gelb MH, Rathod PK, Van Voorhis WC. Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum. J Biol Chem. 2005 Apr 08; 280(14):13554-9. PMID: 15661734.
      View in: PubMed
    50. Shelby JP, White J, Ganesan K, Rathod PK, Chiu DT. A microfluidic model for single-cell capillary obstruction by Plasmodium falciparum-infected erythrocytes. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):14618-22. PMID: 14638939; PMCID: PMC299747.
    51. Rathod PK, Phillips MA. Prized malaria drug target nailed. Nat Struct Biol. 2003 May; 10(5):316-8. PMID: 12714998.
      View in: PubMed
    52. Ganesan K, Jiang L, Rathod PK. Stochastic versus stable transcriptional differences on Plasmodium falciparum DNA microarrays. Int J Parasitol. 2002 Dec 04; 32(13):1543-50. PMID: 12435438.
      View in: PubMed
    53. Baldwin J, Farajallah AM, Malmquist NA, Rathod PK, Phillips MA. Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity. J Biol Chem. 2002 Nov 01; 277(44):41827-34. PMID: 12189151.
      View in: PubMed
    54. Zhang K, Rathod PK. Divergent regulation of dihydrofolate reductase between malaria parasite and human host. Science. 2002 Apr 19; 296(5567):545-7. PMID: 11964483; PMCID: PMC3830934.
    55. Rathod PK, Ganesan K, Hayward RE, Bozdech Z, DeRisi JL. DNA microarrays for malaria. Trends Parasitol. 2002 Jan; 18(1):39-45. PMID: 11850013.
      View in: PubMed
    56. Alfadhli S, Rathod PK. Gene organization of a Plasmodium falciparum serine hydroxymethyltransferase and its functional expression in Escherichia coli. Mol Biochem Parasitol. 2000 Oct; 110(2):283-91. PMID: 11071283.
      View in: PubMed
    57. Jiang L, Lee PC, White J, Rathod PK. Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum. Antimicrob Agents Chemother. 2000 Apr; 44(4):1047-50. PMID: 10722510; PMCID: PMC89811.
    58. Hayward RE, Derisi JL, Alfadhli S, Kaslow DC, Brown PO, Rathod PK. Shotgun DNA microarrays and stage-specific gene expression in Plasmodium falciparum malaria. Mol Microbiol. 2000 Jan; 35(1):6-14. PMID: 10632873.
      View in: PubMed
    59. Shallom S, Zhang K, Jiang L, Rathod PK. Essential protein-protein interactions between Plasmodium falciparum thymidylate synthase and dihydrofolate reductase domains. J Biol Chem. 1999 Dec 31; 274(53):37781-6. PMID: 10608839; PMCID: PMC3791593.
    60. Hekmat-Nejad M, Rathod PK. Plasmodium falciparum: kinetic interactions of WR99210 with pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase. Exp Parasitol. 1997 Nov; 87(3):222-8. PMID: 9371087.
      View in: PubMed
    61. Rathod PK, McErlean T, Lee PC. Variations in frequencies of drug resistance in Plasmodium falciparum. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9389-93. PMID: 9256492; PMCID: PMC23200.
    62. Lauer SA, Rathod PK, Ghori N, Haldar K. A membrane network for nutrient import in red cells infected with the malaria parasite. Science. 1997 May 16; 276(5315):1122-5. PMID: 9148808.
      View in: PubMed
    63. Hekmat-Nejad M, Lee PC, Rathod PK. Plasmodium falciparum: direct cloning and expression of pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase domains. Exp Parasitol. 1997 Mar; 85(3):303-5. PMID: 9085928.
      View in: PubMed
    64. Hekmat-Nejad M, Rathod PK. Kinetics of Plasmodium falciparum thymidylate synthase: interactions with high-affinity metabolites of 5-fluoroorotate and D1694. Antimicrob Agents Chemother. 1996 Jul; 40(7):1628-32. PMID: 8807052; PMCID: PMC163385.
    65. Gassis S, Rathod PK. Frequency of drug resistance in Plasmodium falciparum: a nonsynergistic combination of 5-fluoroorotate and atovaquone suppresses in vitro resistance. Antimicrob Agents Chemother. 1996 Apr; 40(4):914-9. PMID: 8849251; PMCID: PMC163230.
    66. Rathod PK, Khosla M, Gassis S, Young RD, Lutz C. Selection and characterization of 5-fluoroorotate-resistant Plasmodium falciparum. Antimicrob Agents Chemother. 1994 Dec; 38(12):2871-6. PMID: 7695275; PMCID: PMC188299.
    67. Leonard PJ, Rathod PK, Golin J. Loss of function mutation in the yeast multiple drug resistance gene PDR5 causes a reduction in chloramphenicol efflux. Antimicrob Agents Chemother. 1994 Oct; 38(10):2492-4. PMID: 7840595; PMCID: PMC284771.
    68. Creedon KA, Rathod PK, Wellems TE. Plasmodium falciparum S-adenosylhomocysteine hydrolase. cDNA identification, predicted protein sequence, and expression in Escherichia coli. J Biol Chem. 1994 Jun 10; 269(23):16364-70. PMID: 8206944.
      View in: PubMed
    69. Rathod PK, Reshmi S. Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase. Antimicrob Agents Chemother. 1994 Mar; 38(3):476-80. PMID: 8203840; PMCID: PMC284483.
    70. Young RD, Rathod PK. Clonal viability measurements on Plasmodium falciparum to assess in vitro schizonticidal activity of leupeptin, chloroquine, and 5-fluoroorotate. Antimicrob Agents Chemother. 1993 May; 37(5):1102-7. PMID: 8517698; PMCID: PMC187909.
    71. Creedon KA, Kaslow DC, Rathod PK, Wellems TE. Identification of a Plasmodium falciparum histone 2A gene. Mol Biochem Parasitol. 1992 Aug; 54(1):113-5. PMID: 1518525.
      View in: PubMed
    72. Rathod PK, Leffers NP, Young RD. Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum. Antimicrob Agents Chemother. 1992 Apr; 36(4):704-11. PMID: 1503432; PMCID: PMC189360.
    73. Rathod PK, Gomez ZM. Plasmodium yoelii: oral delivery of 5-fluoroorotate to treat malaria in mice. Exp Parasitol. 1991 Nov; 73(4):512-4. PMID: 1959576.
      View in: PubMed
    74. Rathod PK, Khatri A. Synthesis and antiproliferative activity of threo-5-fluoro-L-dihydroorotate. J Biol Chem. 1990 Aug 25; 265(24):14242-9. PMID: 2167311.
      View in: PubMed
    75. Gómez ZM, Rathod PK. Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice. Antimicrob Agents Chemother. 1990 Jul; 34(7):1371-5. PMID: 2386369; PMCID: PMC175983.
    76. Rathod PK, Khatri A, Hubbert T, Milhous WK. Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro. Antimicrob Agents Chemother. 1989 Jul; 33(7):1090-4. PMID: 2675756; PMCID: PMC176067.
    77. Reyes P, Rathod PK. Dihydrofolate reductase: a coupled radiometric assay. Methods Enzymol. 1986; 122:360-7. PMID: 3517568.
      View in: PubMed
    78. Rathod PK, Reyes P. Orotidylate-metabolizing enzymes of the human malarial parasite, Plasmodium falciparum, differ from host cell enzymes. J Biol Chem. 1983 Mar 10; 258(5):2852-5. PMID: 6338005.
      View in: PubMed
    79. Reyes P, Rathod PK, Sanchez DJ, Mrema JE, Rieckmann KH, Heidrich HG. Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum. Mol Biochem Parasitol. 1982 May; 5(5):275-90. PMID: 6285190.
      View in: PubMed
    Rathod's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    Co-Authors Expand Description
    Similar People Expand Description
    Same Department Expand Description