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Dr Hernando Del Portillo

TitlePhD affiliate
InstitutionInstitució Catalana de Recerca i Estudis Avancats
DepartmentInstitut de Salut Global
AddressBarcelona
Spain
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    Collapse Overview 
    Collapse overview
    PRESIDENT:
    Grupo EspañoL de Investigación e Innovación en vesículas Extracelulares – GEIVEX
    (http://geivex.org)

    COORDINATOR:
    Network of excellency in research and innovation on exosomes – REDiEX (http://rediex.org)

    FOUNDER AND CSO:
    INNOVEX THERAPEUTICS SL (http://innovexther.com)

    AFFILIATION:
    ICREA at IS Global Institute for Global Health, Hospital Clínic - Universitat de Barcelona,
    Barcelona, Spain and IGTP Institut d’Investigació Germans Trias i Pujol, Badalona, Spain

    PROFESSIONAL ADDRESS:
    Ctra. de Can Ruti. Camí de les Escoles, s/n, 08916 BADALONA (Barcelona), Spain
    phone +34 690737229, fax +34 93 312 9410, e-mail hernandoa.delportillo@isglobal.org

    EDUCATION:
    - June 1985: Ph.D. Biology, University of Georgia. Athens, GA, USA. Professor Raymond T.
    Damian, Advisor
    Thesis: Immunochemical analysis of baboon IgG subclasses.
    - June 1981: M.Sc. Biology, Wake Forest University. Winston-Salem, USA. Dr. Ronald V.
    Dimock, Advisor.
    Thesis: Host-induced negative phototaxis in the association Unionicola formosa-Anodonta sp.
    - December 1977: B.Sc. Biology and Chemistry. Universidad de La Salle, Bogotá, Colombia.
    Thesis: Karyotype of Aotus griseimembra.

    PROFESSIONAL EXPERIENCE:
    2015: ICREA at IS Global Institute for Global Health, Hospital Clínic - Universitat de
    Barcelona, Barcelona, Spain and IGTP Institut d’Investigació Germans Trias i Pujol, Badalona,Spain
    2007-2015: ICREA Research Professor, Barcelona Centre for International Health Research– CRESIB
    2001-2006: Associate Professor, Dept. of Parasitology, University of São Paulo, São Paulo,Brazil.
    1991-2001: Assistant Professor, Dept. of Parasitology, University of São Paulo, São Paulo,Brazil.
    1987-1990: Post-Doctoral Fellow, Unité d'Immuno-parasitologie, Institut Pasteur, France. Dr.
    Peter H. David, Advisor. Research Area: Molecular Biology of Plasmodium vivax
    1985-1987: Post-Doctoral Fellow, Dept. of Medical and Molecular Parasitology, NYU
    Medical Center, New York, N.Y., Dr. Vincenzo Enea, Advisor. Research Area: Molecular
    Biology of Plasmodium falciparum

    SCHOLARSHIPS:
    1998-1999: Visiting Professor Fellowship from the University of Heidelberg.
    1985-1990: Fellowship from the World Health. Organization (WHO).
    1981-1985: Ph.D. Research Assistantship. As part of a National Institutes of Health Grant given to Professor Raymond T. Damian.

    TRAINING ABROAD:
    1998- 1999: Prof. Herman Bujard. Center for Molecular Biology, University of Heidelberg.
    Sabbatical year (March – October)
    1997: Prof. Herman Bujard. Center for Molecular Biology, University of Heidelberg. Expression
    of malarial proteins in a heterologous inducible tTA system (May).
    1995: Dr. Andy P. Waters, Department of Parasitology, University of Leiden. Transfection of Malaria Parasites (July -October).

    PATENTS
    - Title: Exosomas y su uso como vacunas.
    No solicitud: P201530775
    OEPM Madrid
    - Title: Exosomes derived from reticulocytes infected with Plasmodium sp., method for
    obtaining them and uses thereof.
    International Application Number: PCT/EP2010/070800.
    International Publication Number: WO 2011/080271 A2

    CONSULTANT:
    Consultant CORPOGEN- Colômbia, HTP methods for the screening of antimalarial compounds Consultant of viral vaccines. Biomanguinhos Rio de Janeiro.
    Consultant OPAS Drug resistance in the Brazilian Amazon Scientific Advisory Board Malaria Resource and Research Center (MR4)


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Montaner-Tarbes S, Novell E, Tarancón V, Borrás FE, Montoya M, Fraile L, Del Portillo HA. Targeted-pig trial on safety and immunogenicity of serum-derived extracellular vesicles enriched fractions obtained from Porcine Respiratory and Reproductive virus infections. Sci Rep. 2018 11 30; 8(1):17487. PMID: 30504834.
      View in: PubMed
    2. Díaz-Varela M, de Menezes-Neto A, Perez-Zsolt D, Gámez-Valero A, Seguí-Barber J, Izquierdo-Useros N, Martinez-Picado J, Fernández-Becerra C, Del Portillo HA. Proteomics study of human cord blood reticulocyte-derived exosomes. Sci Rep. 2018 09 19; 8(1):14046. PMID: 30232403.
      View in: PubMed
    3. Elizalde-Torrent A, Val F, Azevedo ICC, Monteiro WM, Ferreira LCL, Fernández-Becerra C, Del Portillo HA, Lacerda MVG. Sudden spleen rupture in a Plasmodium vivax-infected patient undergoing malaria treatment. Malar J. 2018 Feb 13; 17(1):79. PMID: 29433507.
      View in: PubMed
    4. De Niz M, Burda PC, Kaiser G, Del Portillo HA, Spielmann T, Frischknecht F, Heussler VT. Progress in imaging methods: insights gained into Plasmodium biology. Nat Rev Microbiol. 2017 01; 15(1):37-54. PMID: 27890922.
      View in: PubMed
    5. Montaner-Tarbes S, Borrás FE, Montoya M, Fraile L, Del Portillo HA. Serum-derived exosomes from non-viremic animals previously exposed to the porcine respiratory and reproductive virus contain antigenic viral proteins. Vet Res. 2016 05 31; 47(1):59. PMID: 27246926.
      View in: PubMed
    6. Vitor-Silva S, Siqueira AM, de Souza Sampaio V, Guinovart C, Reyes-Lecca RC, de Melo GC, Monteiro WM, Del Portillo HA, Alonso P, Bassat Q, Lacerda MV. Declining malaria transmission in rural Amazon: changing epidemiology and challenges to achieve elimination. Malar J. 2016 05 10; 15(1):266. PMID: 27165432.
      View in: PubMed
    7. Lener T, Gimona M, Aigner L, Börger V, Buzas E, Camussi G, Chaput N, Chatterjee D, Court FA, Del Portillo HA, O'Driscoll L, Fais S, Falcon-Perez JM, Felderhoff-Mueser U, Fraile L, Gho YS, Görgens A, Gupta RC, Hendrix A, Hermann DM, Hill AF, Hochberg F, Horn PA, de Kleijn D, Kordelas L, Kramer BW, Krämer-Albers EM, Laner-Plamberger S, Laitinen S, Leonardi T, Lorenowicz MJ, Lim SK, Lötvall J, Maguire CA, Marcilla A, Nazarenko I, Ochiya T, Patel T, Pedersen S, Pocsfalvi G, Pluchino S, Quesenberry P, Reischl IG, Rivera FJ, Sanzenbacher R, Schallmoser K, Slaper-Cortenbach I, Strunk D, Tonn T, Vader P, van Balkom BW, Wauben M, Andaloussi SE, Théry C, Rohde E, Giebel B. Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper. J Extracell Vesicles. 2015; 4:30087. PMID: 26725829.
      View in: PubMed
    8. Bhardwaj R, Shakri AR, Hans D, Gupta P, Fernandez-Becerra C, Del Portillo HA, Pandey G, Chitnis CE. Production of recombinant PvDBPII, receptor binding domain of Plasmodium vivax Duffy binding protein, and evaluation of immunogenicity to identify an adjuvant formulation for vaccine development. Protein Expr Purif. 2017 Aug; 136:52-57. PMID: 26578115.
      View in: PubMed
    9. de Menezes-Neto A, Sáez MJ, Lozano-Ramos I, Segui-Barber J, Martin-Jaular L, Ullate JM, Fernandez-Becerra C, Borrás FE, Del Portillo HA. Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals. J Extracell Vesicles. 2015; 4:27378. PMID: 26154623.
      View in: PubMed
    10. Mongui A, Pérez-Llanos FJ, Yamamoto MM, Lozano M, Zambrano MM, Del Portillo P, Fernández-Becerra C, Restrepo S, Del Portillo HA, Junca H. Development of a genetic tool for functional screening of anti-malarial bioactive extracts in metagenomic libraries. Malar J. 2015 Jun 04; 14:233. PMID: 26040274.
      View in: PubMed
    11. Lozano-Ramos I, Bancu I, Oliveira-Tercero A, Armengol MP, Menezes-Neto A, Del Portillo HA, Lauzurica-Valdemoros R, Borràs FE. Size-exclusion chromatography-based enrichment of extracellular vesicles from urine samples. J Extracell Vesicles. 2015; 4:27369. PMID: 26025625.
      View in: PubMed
    12. Yáñez-Mó M, Siljander PR, Andreu Z, Zavec AB, Borràs FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, Colás E, Cordeiro-da Silva A, Fais S, Falcon-Perez JM, Ghobrial IM, Giebel B, Gimona M, Graner M, Gursel I, Gursel M, Heegaard NH, Hendrix A, Kierulf P, Kokubun K, Kosanovic M, Kralj-Iglic V, Krämer-Albers EM, Laitinen S, Lässer C, Lener T, Ligeti E, Line A, Lipps G, Llorente A, Lötvall J, Mancek-Keber M, Marcilla A, Mittelbrunn M, Nazarenko I, Nolte-'t Hoen EN, Nyman TA, O'Driscoll L, Olivan M, Oliveira C, Pállinger É, Del Portillo HA, Reventós J, Rigau M, Rohde E, Sammar M, Sánchez-Madrid F, Santarém N, Schallmoser K, Ostenfeld MS, Stoorvogel W, Stukelj R, Van der Grein SG, Vasconcelos MH, Wauben MH, De Wever O. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015; 4:27066. PMID: 25979354.
      View in: PubMed
    13. De Niz M, Helm S, Horstmann S, Annoura T, Del Portillo HA, Khan SM, Heussler VT. In vivo and in vitro characterization of a Plasmodium liver stage-specific promoter. PLoS One. 2015; 10(4):e0123473. PMID: 25874388.
      View in: PubMed
    14. Marcilla A, Martin-Jaular L, Trelis M, de Menezes-Neto A, Osuna A, Bernal D, Fernandez-Becerra C, Almeida IC, Del Portillo HA. Extracellular vesicles in parasitic diseases. J Extracell Vesicles. 2014; 3:25040. PMID: 25536932.
      View in: PubMed
    15. Montaner S, Galiano A, Trelis M, Martin-Jaular L, Del Portillo HA, Bernal D, Marcilla A. The Role of Extracellular Vesicles in Modulating the Host Immune Response during Parasitic Infections. Front Immunol. 2014; 5:433. PMID: 25250031.
      View in: PubMed
    16. Melo GC, Monteiro WM, Siqueira AM, Silva SR, Magalhães BM, Alencar AC, Kuehn A, del Portillo HA, Fernandez-Becerra C, Lacerda MV. Expression levels of pvcrt-o and pvmdr-1 are associated with chloroquine resistance and severe Plasmodium vivax malaria in patients of the Brazilian Amazon. PLoS One. 2014; 9(8):e105922. PMID: 25157811.
      View in: PubMed
    17. Rigat-Brugarolas LG, Elizalde-Torrent A, Bernabeu M, De Niz M, Martin-Jaular L, Fernandez-Becerra C, Homs-Corbera A, Samitier J, del Portillo HA. A functional microengineered model of the human splenon-on-a-chip. Lab Chip. 2014 May 21; 14(10):1715-24. PMID: 24663955.
      View in: PubMed
    18. Lopes SC, Albrecht L, Carvalho BO, Siqueira AM, Thomson-Luque R, Nogueira PA, Fernandez-Becerra C, Del Portillo HA, Russell BM, Rénia L, Lacerda MV, Costa FT. Paucity of Plasmodium vivax mature schizonts in peripheral blood is associated with their increased cytoadhesive potential. J Infect Dis. 2014 May 01; 209(9):1403-7. PMID: 24415786.
      View in: PubMed
    19. Martín-Jaular L, Elizalde-Torrent A, Thomson-Luque R, Ferrer M, Segovia JC, Herreros-Aviles E, Fernández-Becerra C, Del Portillo HA. Reticulocyte-prone malaria parasites predominantly invade CD71hi immature cells: implications for the development of an in vitro culture for Plasmodium vivax. Malar J. 2013 Dec 01; 12:434. PMID: 24289105.
      View in: PubMed
    20. Fernandez-Becerra C, Lelievre J, Ferrer M, Anton N, Thomson R, Peligero C, Almela MJ, Lacerda MV, Herreros E, Del Portillo HA. Red blood cells derived from peripheral blood and bone marrow CD34? human haematopoietic stem cells are permissive to Plasmodium parasites infection. Mem Inst Oswaldo Cruz. 2013 Sep; 108(6):801-3. PMID: 24037205.
      View in: PubMed
    21. Ferrer M, Martin-Jaular L, De Niz M, Khan SM, Janse CJ, Calvo M, Heussler V, del Portillo HA. Imaging of the spleen in malaria. Parasitol Int. 2014 Feb; 63(1):195-205. PMID: 23999413.
      View in: PubMed
    22. Versiani FG, Almeida ME, Melo GC, Versiani FO, Orlandi PP, Mariúba LA, Soares LA, Souza LP, da Silva Balieiro AA, Monteiro WM, Costa FT, del Portillo HA, Lacerda MV, Nogueira PA. High levels of IgG3 anti ICB2-5 in Plasmodium vivax-infected individuals who did not develop symptoms. Malar J. 2013 Aug 27; 12:294. PMID: 23977965.
      View in: PubMed
    23. Del Portillo HA, Chitnis CE. Talking to each other to initiate sexual differentiation. Cell. 2013 May 23; 153(5):945-7. PMID: 23706733.
      View in: PubMed
    24. Borràs FE, Falcón-Pérez JM, Marcilla A, Mittelbrunn M, Del Portillo HA, Sánchez-Madrid F, Yáñez-Mó M. First Symposium of "Grupo Español de Investigación en Vesículas Extracelulares (GEIVEX)", Segovia, 8-9 November 2012. J Extracell Vesicles. 2013; 2:20256. PMID: 26082316.
      View in: PubMed
    25. Lopez FJ, Bernabeu M, Fernandez-Becerra C, del Portillo HA. A new computational approach redefines the subtelomeric vir superfamily of Plasmodium vivax. BMC Genomics. 2013 Jan 16; 14:8. PMID: 23324551.
      View in: PubMed
    26. Sanchez CP, Pfahler J, Del Portillo HA, Lanzer M. Transient transfection of Plasmodium vivax blood-stage parasites. Methods Mol Biol. 2013; 923:151-9. PMID: 22990776.
      View in: PubMed
    27. Machado Siqueira A, Lopes Magalhães BM, Cardoso Melo G, Ferrer M, Castillo P, Martin-Jaular L, Fernandez-Becerra C, Ordi J, Martinez A, Lacerda MV, del Portillo HA. Spleen rupture in a case of untreated Plasmodium vivax infection. PLoS Negl Trop Dis. 2012; 6(12):e1934. PMID: 23272256.
      View in: PubMed
    28. Bernabeu M, Gomez-Perez GP, Sissoko S, Niambélé MB, Haibala AA, Sanz A, Théra MA, Fernandez-Becerra C, Traoré K, Alonso PL, Bassat Q, Del Portillo HA, Doumbo O. Plasmodium vivax malaria in Mali: a study from three different regions. Malar J. 2012 Dec 05; 11:405. PMID: 23217064.
      View in: PubMed
    29. Betuela I, Rosanas-Urgell A, Kiniboro B, Stanisic DI, Samol L, de Lazzari E, Del Portillo HA, Siba P, Alonso PL, Bassat Q, Mueller I. Relapses contribute significantly to the risk of Plasmodium vivax infection and disease in Papua New Guinean children 1-5 years of age. J Infect Dis. 2012 Dec 01; 206(11):1771-80. PMID: 22966124.
      View in: PubMed
    30. Rosanas-Urgell A, Martin-Jaular L, Ricarte-Filho J, Ferrer M, Kalko S, Kimura E, Del Portillo HA. Expression of non-TLR pattern recognition receptors in the spleen of BALB/c mice infected with Plasmodium yoelii and Plasmodium chabaudi chabaudi AS. Mem Inst Oswaldo Cruz. 2012 May; 107(3):410-5. PMID: 22510838.
      View in: PubMed
    31. Del Portillo HA, Ferrer M, Brugat T, Martin-Jaular L, Langhorne J, Lacerda MV. The role of the spleen in malaria. Cell Microbiol. 2012 Mar; 14(3):343-55. PMID: 22188297.
      View in: PubMed
    32. Ferrer M, Martin-Jaular L, Calvo M, del Portillo HA. Intravital microscopy of the spleen: quantitative analysis of parasite mobility and blood flow. J Vis Exp. 2012 Jan 14; (59). PMID: 22298018.
      View in: PubMed
    33. Bernabeu M, Lopez FJ, Ferrer M, Martin-Jaular L, Razaname A, Corradin G, Maier AG, Del Portillo HA, Fernandez-Becerra C. Functional analysis of Plasmodium vivax VIR proteins reveals different subcellular localizations and cytoadherence to the ICAM-1 endothelial receptor. Cell Microbiol. 2012 Mar; 14(3):386-400. PMID: 22103402.
      View in: PubMed
    34. Martin-Jaular L, Nakayasu ES, Ferrer M, Almeida IC, Del Portillo HA. Exosomes from Plasmodium yoelii-infected reticulocytes protect mice from lethal infections. PLoS One. 2011; 6(10):e26588. PMID: 22046311.
      View in: PubMed
    35. Rui E, Fernandez-Becerra C, Takeo S, Sanz S, Lacerda MV, Tsuboi T, del Portillo HA. Plasmodium vivax: comparison of immunogenicity among proteins expressed in the cell-free systems of Escherichia coli and wheat germ by suspension array assays. Malar J. 2011 Jul 14; 10:192. PMID: 21756349.
      View in: PubMed
    36. Rosanas-Urgell A, Mueller D, Betuela I, Barnadas C, Iga J, Zimmerman PA, del Portillo HA, Siba P, Mueller I, Felger I. Comparison of diagnostic methods for the detection and quantification of the four sympatric Plasmodium species in field samples from Papua New Guinea. Malar J. 2010 Dec 14; 9:361. PMID: 21156052.
      View in: PubMed
    37. Martin-Jaular L, Ferrer M, Calvo M, Rosanas-Urgell A, Kalko S, Graewe S, Soria G, Cortadellas N, Ordi J, Planas A, Burns J, Heussler V, del Portillo HA. Strain-specific spleen remodelling in Plasmodium yoelii infections in Balb/c mice facilitates adherence and spleen macrophage-clearance escape. Cell Microbiol. 2011 Jan; 13(1):109-22. PMID: 20923452.
      View in: PubMed
    38. Carvalho BO, Lopes SC, Nogueira PA, Orlandi PP, Bargieri DY, Blanco YC, Mamoni R, Leite JA, Rodrigues MM, Soares IS, Oliveira TR, Wunderlich G, Lacerda MV, del Portillo HA, Araújo MO, Russell B, Suwanarusk R, Snounou G, Rénia L, Costa FT. On the cytoadhesion of Plasmodium vivax-infected erythrocytes. J Infect Dis. 2010 Aug 15; 202(4):638-47. PMID: 20617923.
      View in: PubMed
    39. Fernandez-Becerra C, Sanz S, Brucet M, Stanisic DI, Alves FP, Camargo EP, Alonso PL, Mueller I, del Portillo HA. Naturally-acquired humoral immune responses against the N- and C-termini of the Plasmodium vivax MSP1 protein in endemic regions of Brazil and Papua New Guinea using a multiplex assay. Malar J. 2010 Jan 21; 9:29. PMID: 20092651.
      View in: PubMed
    40. Mueller I, Galinski MR, Baird JK, Carlton JM, Kochar DK, Alonso PL, del Portillo HA. Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite. Lancet Infect Dis. 2009 Sep; 9(9):555-66. PMID: 19695492.
      View in: PubMed
    41. Orjuela-Sánchez P, de Santana Filho FS, Machado-Lima A, Chehuan YF, Costa MR, Alecrim Md, del Portillo HA. Analysis of single-nucleotide polymorphisms in the crt-o and mdr1 genes of Plasmodium vivax among chloroquine-resistant isolates from the Brazilian Amazon region. Antimicrob Agents Chemother. 2009 Aug; 53(8):3561-4. PMID: 19451296.
      View in: PubMed
    42. Fernández-Becerra C, Pinazo MJ, González A, Alonso PL, del Portillo HA, Gascón J. Increased expression levels of the pvcrt-o and pvmdr1 genes in a patient with severe Plasmodium vivax malaria. Malar J. 2009 Apr 02; 8:55. PMID: 19341456.
      View in: PubMed
    43. Fernandez-Becerra C, Yamamoto MM, Vêncio RZ, Lacerda M, Rosanas-Urgell A, del Portillo HA. Plasmodium vivax and the importance of the subtelomeric multigene vir superfamily. Trends Parasitol. 2009 Jan; 25(1):44-51. PMID: 19036639.
      View in: PubMed
    44. Carlton JM, Adams JH, Silva JC, Bidwell SL, Lorenzi H, Caler E, Crabtree J, Angiuoli SV, Merino EF, Amedeo P, Cheng Q, Coulson RM, Crabb BS, Del Portillo HA, Essien K, Feldblyum TV, Fernandez-Becerra C, Gilson PR, Gueye AH, Guo X, Kang'a S, Kooij TW, Korsinczky M, Meyer EV, Nene V, Paulsen I, White O, Ralph SA, Ren Q, Sargeant TJ, Salzberg SL, Stoeckert CJ, Sullivan SA, Yamamoto MM, Hoffman SL, Wortman JR, Gardner MJ, Galinski MR, Barnwell JW, Fraser-Liggett CM. Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature. 2008 Oct 09; 455(7214):757-63. PMID: 18843361.
      View in: PubMed
    45. Machado-Lima A, del Portillo HA, Durham AM. Computational methods in noncoding RNA research. J Math Biol. 2008 Jan; 56(1-2):15-49. PMID: 17786447.
      View in: PubMed
    46. Azevedo MF, del Portillo HA. Promoter regions of Plasmodium vivax are poorly or not recognized by Plasmodium falciparum. Malar J. 2007 Feb 21; 6:20. PMID: 17313673.
      View in: PubMed
    47. Oliveira TR, Fernandez-Becerra C, Jimenez MC, Del Portillo HA, Soares IS. Evaluation of the acquired immune responses to Plasmodium vivax VIR variant antigens in individuals living in malaria-endemic areas of Brazil. Malar J. 2006 Oct 06; 5:83. PMID: 17026752.
      View in: PubMed
    48. Sá JM, Yamamoto MM, Fernandez-Becerra C, de Azevedo MF, Papakrivos J, Naudé B, Wellems TE, Del Portillo HA. Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt, in Plasmodium falciparum and Dictyostelium discoideum. Mol Biochem Parasitol. 2006 Dec; 150(2):219-28. PMID: 16987557.
      View in: PubMed
    49. Albrecht L, Merino EF, Hoffmann EH, Ferreira MU, de Mattos Ferreira RG, Osakabe AL, Dalla Martha RC, Ramharter M, Durham AM, Ferreira JE, Del Portillo HA, Wunderlich G. Extense variant gene family repertoire overlap in Western Amazon Plasmodium falciparum isolates. Mol Biochem Parasitol. 2006 Dec; 150(2):157-65. PMID: 16938359.
      View in: PubMed
    50. Merino EF, Fernandez-Becerra C, Durham AM, Ferreira JE, Tumilasci VF, d'Arc-Neves J, da Silva-Nunes M, Ferreira MU, Wickramarachchi T, Udagama-Randeniya P, Handunnetti SM, Del Portillo HA. Multi-character population study of the vir subtelomeric multigene superfamily of Plasmodium vivax, a major human malaria parasite. Mol Biochem Parasitol. 2006 Sep; 149(1):10-6. PMID: 16730808.
      View in: PubMed
    51. Nogueira PA, Alves FP, Fernandez-Becerra C, Pein O, Santos NR, Pereira da Silva LH, Camargo EP, del Portillo HA. A reduced risk of infection with Plasmodium vivax and clinical protection against malaria are associated with antibodies against the N terminus but not the C terminus of merozoite surface protein 1. Infect Immun. 2006 May; 74(5):2726-33. PMID: 16622209.
      View in: PubMed
    52. Hoffmann EH, Malafronte RS, Moraes-Avila SL, Osakabe AL, Wunderlich G, Durham AM, Ribolla PE, del Portillo HA, Ferreira MU. Origins of sequence diversity in the malaria vaccine candidate merozoite surface protein-2 (MSP-2) in Amazonian isolates of Plasmodium falciparum. Gene. 2006 Jul 19; 376(2):224-30. PMID: 16716539.
      View in: PubMed
    53. Fernandez-Becerra C, Pein O, de Oliveira TR, Yamamoto MM, Cassola AC, Rocha C, Soares IS, de Bragança Pereira CA, del Portillo HA. Variant proteins of Plasmodium vivax are not clonally expressed in natural infections. Mol Microbiol. 2005 Nov; 58(3):648-58. PMID: 16238616.
      View in: PubMed
    54. Kirchgatter K, Del Portillo HA. Clinical and molecular aspects of severe malaria. An Acad Bras Cienc. 2005 Sep; 77(3):455-75. PMID: 16127552.
      View in: PubMed
    55. Llinás M, del Portillo HA. Mining the malaria transcriptome. Trends Parasitol. 2005 Aug; 21(8):350-2. PMID: 15979411.
      View in: PubMed
    56. Sá JM, Nomura T, Neves Jd, Baird JK, Wellems TE, del Portillo HA. Plasmodium vivax: allele variants of the mdr1 gene do not associate with chloroquine resistance among isolates from Brazil, Papua, and monkey-adapted strains. Exp Parasitol. 2005 Apr; 109(4):256-9. PMID: 15755424.
      View in: PubMed
    57. del Portillo HA, Lanzer M, Rodriguez-Malaga S, Zavala F, Fernandez-Becerra C. Variant genes and the spleen in Plasmodium vivax malaria. Int J Parasitol. 2004 Dec; 34(13-14):1547-54. PMID: 15582531.
      View in: PubMed
    58. Cassera MB, Gozzo FC, D'Alexandri FL, Merino EF, del Portillo HA, Peres VJ, Almeida IC, Eberlin MN, Wunderlich G, Wiesner J, Jomaa H, Kimura EA, Katzin AM. The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum. J Biol Chem. 2004 Dec 10; 279(50):51749-59. PMID: 15452112.
      View in: PubMed
    59. Janse CJ, Haghparast A, Sperança MA, Ramesar J, Kroeze H, del Portillo HA, Waters AP. Malaria parasites lacking eef1a have a normal S/M phase yet grow more slowly due to a longer G1 phase. Mol Microbiol. 2003 Dec; 50(5):1539-51. PMID: 14651637.
      View in: PubMed
    60. Merino EF, Fernandez-Becerra C, Madeira AM, Machado AL, Durham A, Gruber A, Hall N, del Portillo HA. Pilot survey of expressed sequence tags (ESTs) from the asexual blood stages of Plasmodium vivax in human patients. Malar J. 2003 Jul 21; 2:21. PMID: 12914668.
      View in: PubMed
    61. Fernandez-Becerra C, de Azevedo MF, Yamamoto MM, del Portillo HA. Plasmodium falciparum: new vector with bi-directional promoter activity to stably express transgenes. Exp Parasitol. 2003 Jan-Feb; 103(1-2):88-91. PMID: 12810052.
      View in: PubMed
    62. Nomura T, Carlton JM, Baird JK, del Portillo HA, Fryauff DJ, Rathore D, Fidock DA, Su X, Collins WE, McCutchan TF, Wootton JC, Wellems TE. Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria. J Infect Dis. 2001 Jun 01; 183(11):1653-61. PMID: 11343215.
      View in: PubMed
    63. del Portillo HA, Fernandez-Becerra C, Bowman S, Oliver K, Preuss M, Sanchez CP, Schneider NK, Villalobos JM, Rajandream MA, Harris D, Pereira da Silva LH, Barrell B, Lanzer M. A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax. Nature. 2001 Apr 12; 410(6830):839-42. PMID: 11298455.
      View in: PubMed
    64. Sperança MA, Vinkenoog R, Ocampos M, Fischer K, Janse CJ, Waters AP, del Portillo HA. Primary structure of the Plasmodium vivax crk2 gene and interference of the yeast cell cycle upon its conditional expression. Exp Parasitol. 2001 Mar; 97(3):119-28. PMID: 11312574.
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    65. Wunderlich G, Moura IC, del Portillo HA. Genetic immunization of BALB/c mice with a plasmid bearing the gene coding for a hybrid merozoite surface protein 1-hepatitis B virus surface protein fusion protects mice against lethal Plasmodium chabaudi chabaudi PC1 infection. Infect Immun. 2000 Oct; 68(10):5839-45. PMID: 10992493.
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    66. Kirchgatter K, Mosbach R, del Portillo HA. Plasmodium falciparum: DBL-1 var sequence analysis in field isolates from central Brazil. Exp Parasitol. 2000 Jun; 95(2):154-7. PMID: 10910718.
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    67. Wunderlich G, del Portillo HA. Biochemical and immunological properties of a viral hybrid particle expressing the Plasmodium vivax merozoite surface protein 1 C-terminal region. Mol Med. 2000 Mar; 6(3):238-45. PMID: 10965497.
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    68. de Oliveira CI, Wunderlich G, Levitus G, Soares IS, Rodrigues MM, Tsuji M, del Portillo HA. Antigenic properties of the merozoite surface protein 1 gene of Plasmodium vivax. Vaccine. 1999 Aug 06; 17(23-24):2959-68. PMID: 10462230.
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    69. Soares IS, da Cunha MG, Silva MN, Souza JM, Del Portillo HA, Rodrigues MM. Longevity of naturally acquired antibody responses to the N- and C-terminal regions of Plasmodium vivax merozoite surface protein 1. Am J Trop Med Hyg. 1999 Mar; 60(3):357-63. PMID: 10466961.
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    70. Vinkenoog R, Sperança MA, Ramesar J, Thomas AW, del Portillo HA, Janse CJ, Waters AP. Characterisation of the Cdc2-related kinase 2 gene from Plasmodium knowlesi and P. berghei. Mol Biochem Parasitol. 1998 Sep 15; 95(2):229-40. PMID: 9803415.
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    71. Vinkenoog R, Sperança MA, van Breemen O, Ramesar J, Williamson DH, Ross-MacDonald PB, Thomas AW, Janse CJ, del Portillo HA, Waters AP. Malaria parasites contain two identical copies of an elongation factor 1 alpha gene. Mol Biochem Parasitol. 1998 Jul 01; 94(1):1-12. PMID: 9719506.
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    72. Kirchgatter K, del Portillo HA. Molecular analysis of Plasmodium vivax relapses using the MSP1 molecule as a genetic marker. J Infect Dis. 1998 Feb; 177(2):511-5. PMID: 9466551.
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    73. Camargo AA, Fischer K, Lanzer M, del Portillo HA. Construction and characterization of a Plasmodium vivax genomic library in yeast artificial chromosomes. Genomics. 1997 Jun 15; 42(3):467-73. PMID: 9205119.
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    74. Soares IS, Levitus G, Souza JM, Del Portillo HA, Rodrigues MM. Acquired immune responses to the N- and C-terminal regions of Plasmodium vivax merozoite surface protein 1 in individuals exposed to malaria. Infect Immun. 1997 May; 65(5):1606-14. PMID: 9125537.
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    75. Levitus G, Mertens F, Kirchgatter K, Oliveira SG, del Portillo HA. Plasmodium vivax: epitope mapping of monoclonal antibodies against the N-terminal region of the merozoite surface protein 1. Behring Inst Mitt. 1997 Mar; (99):107-11. PMID: 9303209.
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    76. Moreira ME, Del Portillo HA, Milder RV, Balanco JM, Barcinski MA. Heat shock induction of apoptosis in promastigotes of the unicellular organism Leishmania (Leishmania) amazonensis. J Cell Physiol. 1996 May; 167(2):305-13. PMID: 8613472.
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    77. Vinkenoog R, Veldhuisen B, Sperança MA, del Portillo HA, Janse C, Waters AP. Comparison of introns in a cdc2-homologous gene within a number of Plasmodium species. Mol Biochem Parasitol. 1995 May; 71(2):233-41. PMID: 7477105.
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    78. Mancilla LI, Levitus G, Kirchgatter K, Mertens F, Herrera S, del Portillo HA. Plasmodium vivax: dimorphic DNA sequences from the MSP-1 gene code for regions that are immunogenic in natural infections. Exp Parasitol. 1994 Sep; 79(2):148-58. PMID: 8056078.
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    79. Levitus G, Mertens F, Speranca MA, Camargo LM, Ferreira MU, del Portillo HA. Characterization of naturally acquired human IgG responses against the N-terminal region of the merozoite surface protein 1 of Plasmodium vivax. Am J Trop Med Hyg. 1994 Jul; 51(1):68-76. PMID: 8059917.
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    80. Janse CJ, Camargo A, Del Portillo HA, Herrera S, Kumlien S, Mons B, Thomas A, Waters AP. Removal of leucocytes from Plasmodium vivax-infected blood. Ann Trop Med Parasitol. 1994 Apr; 88(2):213-6. PMID: 8067817.
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    81. Levitus G, del Portillo HA. Advances toward the development of an asexual blood stage MSP-1 vaccine of Plasmodium vivax. Mem Inst Oswaldo Cruz. 1994; 89 Suppl 2:81-4. PMID: 7565138.
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    82. Mertens F, Levitus G, Camargo LM, Ferreira MU, Dutra AP, Del Portillo HA. Longitudinal study of naturally acquired humoral immune responses against the merozoite surface protein 1 of Plasmodium vivax in patients from Rondonia, Brazil. Am J Trop Med Hyg. 1993 Sep; 49(3):383-92. PMID: 8372960.
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    83. Porto M, Ferreira MU, Camargo LM, Premawansa S, del Portillo HA. Second form in a segment of the merozoite surface protein 1 gene of Plasmodium vivax among isolates from Rondônia (Brazil). Mol Biochem Parasitol. 1992 Aug; 54(1):121-4. PMID: 1518527.
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    84. del Portillo HA, Levitus G, Camargo LM, Ferreira MU, Mertens F. Human IgG responses against the N-terminal region of the Merozoite Surface Protein 1 of Plasmodium vivax. Mem Inst Oswaldo Cruz. 1992; 87 Suppl 3:77-84. PMID: 1343729.
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    85. del Portillo HA, Longacre S, Khouri E, David PH. Primary structure of the merozoite surface antigen 1 of Plasmodium vivax reveals sequences conserved between different Plasmodium species. Proc Natl Acad Sci U S A. 1991 May 01; 88(9):4030-4. PMID: 2023952.
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    86. del Portillo HA, Gysin J, Mattei DM, Khouri E, Udagama PV, Mendis KN, David PH. Plasmodium vivax: cloning and expression of a major blood-stage surface antigen. Exp Parasitol. 1988 Dec; 67(2):346-53. PMID: 3056739.
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    87. David PH, del Portillo HA, Mendis KN. Plasmodium vivax malaria: parasite biology defines potential targets for vaccine development. Biol Cell. 1988; 64(2):251-60. PMID: 3067803.
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    88. Yoshida N, del Portillo HA, di Santi SM, Nussenzweig RS, Enea V. Plasmodium falciparum: epidemiological studies on the circumsporozoite gene. Exp Parasitol. 1987 Dec; 64(3):510-3. PMID: 3315737.
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    89. Del Portillo HA, Schmidt GW, Damian RT. Immunochemical analysis of baboon (Papio cynocephalus) IgG subclasses. Vet Immunol Immunopathol. 1987 Nov; 16(3-4):201-14. PMID: 3124330.
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    90. del Portillo HA, Nussenzweig RS, Enea V. Circumsporozoite gene of a Plasmodium falciparum strain from Thailand. Mol Biochem Parasitol. 1987 Jul; 24(3):289-94. PMID: 3306373.
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    91. del Portillo HA, Damian RT. Experimental Schistosoma mansoni infection in a small New World monkey, the saddle-back tamarin (Saguinus fuscicollis). Am J Trop Med Hyg. 1986 May; 35(3):515-22. PMID: 3085525.
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