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Professor Graham Coombs

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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Westrop GD, Williams RA, Wang L, Zhang T, Watson DG, Silva AM, Coombs GH. Metabolomic Analyses of Leishmania Reveal Multiple Species Differences and Large Differences in Amino Acid Metabolism. PLoS One. 2015; 10(9):e0136891. PMID: 26368322; PMCID: PMC4569581.
    2. Zhang R, Watson DG, Wang L, Westrop GD, Coombs GH, Zhang T. Evaluation of mobile phase characteristics on three zwitterionic columns in hydrophilic interaction liquid chromatography mode for liquid chromatography-high resolution mass spectrometry based untargeted metabolite profiling of Leishmania parasites. J Chromatogr A. 2014 Oct 03; 1362:168-79. PMID: 25160959.
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    3. Storm J, Sethia S, Blackburn GJ, Chokkathukalam A, Watson DG, Breitling R, Coombs GH, Müller S. Phosphoenolpyruvate carboxylase identified as a key enzyme in erythrocytic Plasmodium falciparum carbon metabolism. PLoS Pathog. 2014 Jan; 10(1):e1003876. PMID: 24453970; PMCID: PMC3894211.
    4. Cull B, Prado Godinho JL, Fernandes Rodrigues JC, Frank B, Schurigt U, Williams RA, Coombs GH, Mottram JC. Glycosome turnover in Leishmania major is mediated by autophagy. Autophagy. 2014; 10(12):2143-57. PMID: 25484087; PMCID: PMC4502677.
    5. Judice WA, Manfredi MA, Souza GP, Sansevero TM, Almeida PC, Shida CS, Gesteira TF, Juliano L, Westrop GD, Sanderson SJ, Coombs GH, Tersariol IL. Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8. PLoS One. 2013; 8(11):e80153. PMID: 24278253; PMCID: PMC3836952.
    6. Schröder J, Noack S, Marhöfer RJ, Mottram JC, Coombs GH, Selzer PM. Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB. PLoS One. 2013; 8(10):e77460. PMID: 24146999; PMCID: PMC3797739.
    7. Tomlins AM, Ben-Rached F, Williams RA, Proto WR, Coppens I, Ruch U, Gilberger TW, Coombs GH, Mottram JC, Müller S, Langsley G. Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation. Autophagy. 2013 Oct; 9(10):1540-52. PMID: 24025672.
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    8. Proto WR, Coombs GH, Mottram JC. Cell death in parasitic protozoa: regulated or incidental? Nat Rev Microbiol. 2013 Jan; 11(1):58-66. PMID: 23202528.
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    9. Williams RA, Mottram JC, Coombs GH. Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of Leishmania major. J Biol Chem. 2013 Feb 01; 288(5):3678-90. PMID: 23166325; PMCID: PMC3561585.
    10. Castanys-Muñoz E, Brown E, Coombs GH, Mottram JC. Leishmania mexicana metacaspase is a negative regulator of amastigote proliferation in mammalian cells. Cell Death Dis. 2012 Sep 06; 3:e385. PMID: 22951982; PMCID: PMC3461358.
    11. Fyfe PK, Westrop GD, Silva AM, Coombs GH, Hunter WN. Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation. Proc Natl Acad Sci U S A. 2012 Jul 17; 109(29):11693-8. PMID: 22753509; PMCID: PMC3406863.
    12. Fyfe PK, Westrop GD, Ramos T, Müller S, Coombs GH, Hunter WN. Structure of Leishmania major cysteine synthase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 01; 68(Pt 7):738-43. PMID: 22750854; PMCID: PMC3388911.
    13. Silva AM, Tavares J, Silvestre R, Ouaissi A, Coombs GH, Cordeiro-da-Silva A. Characterization of Leishmania infantum thiol-dependent reductase 1 and evaluation of its potential to induce immune protection. Parasite Immunol. 2012 Jun; 34(6):345-50. PMID: 22416787.
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    14. Williams RA, Smith TK, Cull B, Mottram JC, Coombs GH. ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major. PLoS Pathog. 2012; 8(5):e1002695. PMID: 22615560; PMCID: PMC3355087.
    15. Morrison LS, Goundry A, Faria MS, Tetley L, Eschenlauer SC, Westrop GD, Dostalova A, Volf P, Coombs GH, Lima AP, Mottram JC. Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation. Cell Microbiol. 2012 Aug; 14(8):1271-86. PMID: 22486816; PMCID: PMC3440592.
    16. McLuskey K, Rudolf J, Proto WR, Isaacs NW, Coombs GH, Moss CX, Mottram JC. Crystal structure of a Trypanosoma brucei metacaspase. Proc Natl Acad Sci U S A. 2012 May 08; 109(19):7469-74. PMID: 22529389; PMCID: PMC3358904.
    17. Alsaadi M, Italia JL, Mullen AB, Ravi Kumar MN, Candlish AA, Williams RA, Shaw CD, Al Gawhari F, Coombs GH, Wiese M, Thomson AH, Puig-Sellart M, Wallace J, Sharp A, Wheeler L, Warn P, Carter KC. The efficacy of aerosol treatment with non-ionic surfactant vesicles containing amphotericin B in rodent models of leishmaniasis and pulmonary aspergillosis infection. J Control Release. 2012 Jun 28; 160(3):685-91. PMID: 22516093.
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    18. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490; PMCID: PMC3404883.
    19. Decuypere S, Vanaerschot M, Brunker K, Imamura H, Müller S, Khanal B, Rijal S, Dujardin JC, Coombs GH. Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background. PLoS Negl Trop Dis. 2012; 6(2):e1514. PMID: 22389733; PMCID: PMC3289598.
    20. Silva AM, Cordeiro-da-Silva A, Coombs GH. Metabolic variation during development in culture of Leishmania donovani promastigotes. PLoS Negl Trop Dis. 2011 Dec; 5(12):e1451. PMID: 22206037; PMCID: PMC3243725.
    21. Schaeffer M, Schroeder J, Heckeroth AR, Noack S, Gassel M, Mottram JC, Selzer PM, Coombs GH. Identification of lead compounds targeting the cathepsin B-like enzyme of Eimeria tenella. Antimicrob Agents Chemother. 2012 Mar; 56(3):1190-201. PMID: 22143531; PMCID: PMC3294901.
    22. Downing T, Imamura H, Decuypere S, Clark TG, Coombs GH, Cotton JA, Hilley JD, de Doncker S, Maes I, Mottram JC, Quail MA, Rijal S, Sanders M, Schönian G, Stark O, Sundar S, Vanaerschot M, Hertz-Fowler C, Dujardin JC, Berriman M. Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance. Genome Res. 2011 Dec; 21(12):2143-56. PMID: 22038251; PMCID: PMC3227103.
    23. Proto WR, Castanys-Munoz E, Black A, Tetley L, Moss CX, Juliano L, Coombs GH, Mottram JC. Trypanosoma brucei metacaspase 4 is a pseudopeptidase and a virulence factor. J Biol Chem. 2011 Nov 18; 286(46):39914-25. PMID: 21949125; PMCID: PMC3220528.
    24. Ambit A, Woods KL, Cull B, Coombs GH, Mottram JC. Morphological events during the cell cycle of Leishmania major. Eukaryot Cell. 2011 Nov; 10(11):1429-38. PMID: 21926331; PMCID: PMC3209043.
    25. Moya IA, Westrop GD, Coombs GH, Honek JF. Mechanistic studies on the enzymatic processing of fluorinated methionine analogues by Trichomonas vaginalis methionine ?-lyase. Biochem J. 2011 Sep 15; 438(3):513-21. PMID: 21658005.
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    26. Duszenko M, Ginger ML, Brennand A, Gualdrón-López M, Colombo MI, Coombs GH, Coppens I, Jayabalasingham B, Langsley G, de Castro SL, Menna-Barreto R, Mottram JC, Navarro M, Rigden DJ, Romano PS, Stoka V, Turk B, Michels PA. Autophagy in protists. Autophagy. 2011 Feb; 7(2):127-58. PMID: 20962583; PMCID: PMC3039767.
    27. t'Kindt R, Scheltema RA, Jankevics A, Brunker K, Rijal S, Dujardin JC, Breitling R, Watson DG, Coombs GH, Decuypere S. Metabolomics to unveil and understand phenotypic diversity between pathogen populations. PLoS Negl Trop Dis. 2010 Nov 30; 4(11):e904. PMID: 21152055; PMCID: PMC2994915.
    28. Steert K, Berg M, Mottram JC, Westrop GD, Coombs GH, Cos P, Maes L, Joossens J, Van der Veken P, Haemers A, Augustyns K. a-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB. ChemMedChem. 2010 Oct 04; 5(10):1734-48. PMID: 20799311; PMCID: PMC3245848.
    29. Munday JC, McLuskey K, Brown E, Coombs GH, Mottram JC. Oligopeptidase B deficient mutants of Leishmania major. Mol Biochem Parasitol. 2011 Jan; 175(1):49-57. PMID: 20883728; PMCID: PMC3130898.
    30. t'Kindt R, Jankevics A, Scheltema RA, Zheng L, Watson DG, Dujardin JC, Breitling R, Coombs GH, Decuypere S. Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis. Anal Bioanal Chem. 2010 Nov; 398(5):2059-69. PMID: 20824428.
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    31. Zheng L, T'Kind R, Decuypere S, von Freyend SJ, Coombs GH, Watson DG. Profiling of lipids in Leishmania donovani using hydrophilic interaction chromatography in combination with Fourier transform mass spectrometry. Rapid Commun Mass Spectrom. 2010 Jul 30; 24(14):2074-82. PMID: 20552712.
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    32. Coombs GH. Insights into the metabolomes of parasites. Preface. Parasitology. 2010 Aug; 137(9):1283. PMID: 20546640.
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    33. Scheltema RA, Decuypere S, T'kindt R, Dujardin JC, Coombs GH, Breitling R. The potential of metabolomics for Leishmania research in the post-genomics era. Parasitology. 2010 Aug; 137(9):1291-302. PMID: 20109253.
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    34. Berg M, Van der Veken P, Joossens J, Muthusamy V, Breugelmans M, Moss CX, Rudolf J, Cos P, Coombs GH, Maes L, Haemers A, Mottram JC, Augustyns K. Design and evaluation of Trypanosoma brucei metacaspase inhibitors. Bioorg Med Chem Lett. 2010 Mar 15; 20(6):2001-6. PMID: 20167486; PMCID: PMC2845880.
    35. Westrop GD, Georg I, Coombs GH. The mercaptopyruvate sulfurtransferase of Trichomonas vaginalis links cysteine catabolism to the production of thioredoxin persulfide. J Biol Chem. 2009 Nov 27; 284(48):33485-94. PMID: 19762467; PMCID: PMC2785193.
    36. Gornik SG, Westrop GD, Coombs GH, Neil DM. Molecular cloning and localization of a calpain-like protease from the abdominal muscle of Norway lobster Nephrops norvegicus. Mol Biol Rep. 2010 Apr; 37(4):2009-19. PMID: 19642014.
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    37. Williams RA, Westrop GD, Coombs GH. Two pathways for cysteine biosynthesis in Leishmania major. Biochem J. 2009 May 27; 420(3):451-62. PMID: 19296828.
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    38. Bryson K, Besteiro S, McGachy HA, Coombs GH, Mottram JC, Alexander J. Overexpression of the natural inhibitor of cysteine peptidases in Leishmania mexicana leads to reduced virulence and a Th1 response. Infect Immun. 2009 Jul; 77(7):2971-8. PMID: 19433541; PMCID: PMC2708542.
    39. Jecna L, Svarovska A, Besteiro S, Mottram JC, Coombs GH, Volf P. Inhibitor of cysteine peptidase does not influence the development of Leishmania mexicana in Lutzomyia longipalpis. J Med Entomol. 2009 May; 46(3):605-9. PMID: 19496433.
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    40. Williams RA, Woods KL, Juliano L, Mottram JC, Coombs GH. Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major. Autophagy. 2009 Feb; 5(2):159-72. PMID: 19066473; PMCID: PMC2642932.
    41. Richardson JM, Morrison LS, Bland ND, Bruce S, Coombs GH, Mottram JC, Walkinshaw MD. Structures of Leishmania major orthologues of macrophage migration inhibitory factor. Biochem Biophys Res Commun. 2009 Mar 13; 380(3):442-8. PMID: 19187777; PMCID: PMC3242041.
    42. McMillan PJ, Patzewitz EM, Young SE, Westrop GD, Coombs GH, Engman L, Müller S. Differential inhibition of high and low Mr thioredoxin reductases of parasites by organotelluriums supports the concept that low Mr thioredoxin reductases are good drug targets. Parasitology. 2009 Jan; 136(1):27-33. PMID: 18980703.
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    43. Eschenlauer SC, Faria MS, Morrison LS, Bland N, Ribeiro-Gomes FL, DosReis GA, Coombs GH, Lima AP, Mottram JC. Influence of parasite encoded inhibitors of serine peptidases in early infection of macrophages with Leishmania major. Cell Microbiol. 2009 Jan; 11(1):106-20. PMID: 19016791; PMCID: PMC2659362.
    44. Lanfranco MF, Loayza-Muro R, Clark D, Núñez R, Zavaleta AI, Jimenez M, Meldal M, Coombs GH, Mottram JC, Izidoro M, Juliano MA, Juliano L, Arévalo J. Expression and substrate specificity of a recombinant cysteine proteinase B of Leishmania braziliensis. Mol Biochem Parasitol. 2008 Oct; 161(2):91-100. PMID: 18639590.
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    45. Besteiro S, Tonn D, Tetley L, Coombs GH, Mottram JC. The AP3 adaptor is involved in the transport of membrane proteins to acidocalcisomes of Leishmania. J Cell Sci. 2008 Mar 01; 121(Pt 5):561-70. PMID: 18252798.
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    46. dos Reis FC, Smith BO, Santos CC, Costa TF, Scharfstein J, Coombs GH, Mottram JC, Lima AP. The role of conserved residues of chagasin in the inhibition of cysteine peptidases. FEBS Lett. 2008 Feb 20; 582(4):485-90. PMID: 18201565; PMCID: PMC2607524.
    47. Moss CX, Westrop GD, Juliano L, Coombs GH, Mottram JC. Metacaspase 2 of Trypanosoma brucei is a calcium-dependent cysteine peptidase active without processing. FEBS Lett. 2007 Dec 11; 581(29):5635-9. PMID: 18005666.
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    48. Steert K, El-Sayed I, Van der Veken P, Krishtal A, Van Alsenoy C, Westrop GD, Mottram JC, Coombs GH, Augustyns K, Haemers A. Dipeptidyl alpha-fluorovinyl Michael acceptors: synthesis and activity against cysteine proteases. Bioorg Med Chem Lett. 2007 Dec 01; 17(23):6563-6. PMID: 17936625.
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    49. Santos CC, Coombs GH, Lima AP, Mottram JC. Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence. Mol Microbiol. 2007 Nov; 66(4):991-1002. PMID: 17944830; PMCID: PMC2680270.
    50. Ambit A, Fasel N, Coombs GH, Mottram JC. An essential role for the Leishmania major metacaspase in cell cycle progression. Cell Death Differ. 2008 Jan; 15(1):113-22. PMID: 17901875.
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    51. Kanaji S, Tanaka Y, Sakata Y, Takeshita K, Arima K, Ohta S, Hansell EJ, Caffrey C, Mottram JC, Lowther J, Donnelly S, Stack C, Kadowaki T, Yamamoto K, McKerrow JH, Dalton JP, Coombs GH, Izuhara K. Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases. FEBS Lett. 2007 Sep 04; 581(22):4260-4. PMID: 17707374.
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    52. Besteiro S, Williams RA, Coombs GH, Mottram JC. Protein turnover and differentiation in Leishmania. Int J Parasitol. 2007 Aug; 37(10):1063-75. PMID: 17493624; PMCID: PMC2244715.
    53. Cortázar TM, Coombs GH, Walker J. Leishmania panamensis: comparative inhibition of nuclear DNA topoisomerase II enzymes from promastigotes and human macrophages reveals anti-parasite selectivity of fluoroquinolones, flavonoids and pentamidine. Exp Parasitol. 2007 Aug; 116(4):475-82. PMID: 17466980.
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    54. Opperdoes FR, Coombs GH. Metabolism of Leishmania: proven and predicted. Trends Parasitol. 2007 Apr; 23(4):149-58. PMID: 17320480.
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    55. Carlton JM, Hirt RP, Silva JC, Delcher AL, Schatz M, Zhao Q, Wortman JR, Bidwell SL, Alsmark UC, Besteiro S, Sicheritz-Ponten T, Noel CJ, Dacks JB, Foster PG, Simillion C, Van de Peer Y, Miranda-Saavedra D, Barton GJ, Westrop GD, Müller S, Dessi D, Fiori PL, Ren Q, Paulsen I, Zhang H, Bastida-Corcuera FD, Simoes-Barbosa A, Brown MT, Hayes RD, Mukherjee M, Okumura CY, Schneider R, Smith AJ, Vanacova S, Villalvazo M, Haas BJ, Pertea M, Feldblyum TV, Utterback TR, Shu CL, Osoegawa K, de Jong PJ, Hrdy I, Horvathova L, Zubacova Z, Dolezal P, Malik SB, Logsdon JM, Henze K, Gupta A, Wang CC, Dunne RL, Upcroft JA, Upcroft P, White O, Salzberg SL, Tang P, Chiu CH, Lee YS, Embley TM, Coombs GH, Mottram JC, Tachezy J, Fraser-Liggett CM, Johnson PJ. Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science. 2007 Jan 12; 315(5809):207-12. PMID: 17218520; PMCID: PMC2080659.
    56. Small HJ, Shields JD, Neil DM, Taylor AC, Coombs GH. Differences in enzyme activities between two species of Hematodinium, parasitic dinoflagellates of crustaceans. J Invertebr Pathol. 2007 Mar; 94(3):175-83. PMID: 17156792.
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    57. Denise H, Poot J, Jiménez M, Ambit A, Herrmann DC, Vermeulen AN, Coombs GH, Mottram JC. Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5. BMC Mol Biol. 2006 Nov 13; 7:42. PMID: 17101050; PMCID: PMC1657026.
    58. Besteiro S, Coombs GH, Mottram JC. The SNARE protein family of Leishmania major. BMC Genomics. 2006 Oct 06; 7:250. PMID: 17026746; PMCID: PMC1626469.
    59. Schaeffer M, de Miranda A, Mottram JC, Coombs GH. Differentiation of Leishmania major is impaired by over-expression of pyroglutamyl peptidase I. Mol Biochem Parasitol. 2006 Dec; 150(2):318-29. PMID: 17028008.
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    60. Eschenlauer SC, Coombs GH, Mottram JC. PFPI-like genes are expressed in Leishmania major but are pseudogenes in other Leishmania species. FEMS Microbiol Lett. 2006 Jul; 260(1):47-54. PMID: 16790017.
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    61. Williams RA, Tetley L, Mottram JC, Coombs GH. Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana. Mol Microbiol. 2006 Aug; 61(3):655-74. PMID: 16803590.
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    62. Westrop GD, Goodall G, Mottram JC, Coombs GH. Cysteine biosynthesis in Trichomonas vaginalis involves cysteine synthase utilizing O-phosphoserine. J Biol Chem. 2006 Sep 01; 281(35):25062-75. PMID: 16735516; PMCID: PMC2645516.
    63. Small HJ, Neil DM, Taylor AC, Atkinson RJ, Coombs GH. Molecular detection of Hematodinium spp. in Norway lobster Nephrops norvegicus and other crustaceans. Dis Aquat Organ. 2006 Apr 06; 69(2-3):185-95. PMID: 16724562.
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    64. Helms MJ, Ambit A, Appleton P, Tetley L, Coombs GH, Mottram JC. Bloodstream form Trypanosoma brucei depend upon multiple metacaspases associated with RAB11-positive endosomes. J Cell Sci. 2006 Mar 15; 119(Pt 6):1105-17. PMID: 16507595.
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    65. Besteiro S, Williams RA, Morrison LS, Coombs GH, Mottram JC. Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major. J Biol Chem. 2006 Apr 21; 281(16):11384-96. PMID: 16497676.
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    66. Iulek J, Alphey MS, Westrop GD, Coombs GH, Hunter WN. High-resolution structure of recombinant Trichomonas vaginalis thioredoxin. Acta Crystallogr D Biol Crystallogr. 2006 Feb; 62(Pt 2):216-20. PMID: 16421453.
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    67. Poot J, Spreeuwenberg K, Sanderson SJ, Schijns VE, Mottram JC, Coombs GH, Vermeulen AN. Vaccination with a preparation based on recombinant cysteine peptidases and canine IL-12 does not protect dogs from infection with Leishmania infantum. Vaccine. 2006 Mar 24; 24(14):2460-8. PMID: 16423430.
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    68. Smith BO, Westrop GD, Mottram JC, Coombs GH. Chemical shift assignments of Leishmania mexicana ICP, a novel cysteine peptidase inhibitor. J Biomol NMR. 2006; 36 Suppl 1:7. PMID: 16596344; PMCID: PMC2592598.
    69. Smith BO, Picken NC, Westrop GD, Bromek K, Mottram JC, Coombs GH. The structure of Leishmania mexicana ICP provides evidence for convergent evolution of cysteine peptidase inhibitors. J Biol Chem. 2006 Mar 03; 281(9):5821-8. PMID: 16407198; PMCID: PMC1473161.
    70. Small HJ, Neil DM, Taylor AC, Coombs GH. Identification and partial characterisation of metalloproteases secreted by a Mesanophrys-like ciliate parasite of the Norway lobster Nephrops norvegicus. Dis Aquat Organ. 2005 Nov 28; 67(3):225-31. PMID: 16408838.
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    71. Jean-Moreno V, Rojas R, Goyeneche D, Coombs GH, Walker J. Leishmania donovani: differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays. Exp Parasitol. 2006 Jan; 112(1):21-30. PMID: 16293247.
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    72. Judice WA, Mottram JC, Coombs GH, Juliano MA, Juliano L. Specific negative charges in cysteine protease isoforms of Leishmaniamexicana are highly influential on the substrate binding and hydrolysis. Mol Biochem Parasitol. 2005 Nov; 144(1):36-43. PMID: 16125801.
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    73. Saravia NG, Escorcia B, Osorio Y, Valderrama L, Brooks D, Arteaga L, Coombs G, Mottram J, Travi BL. Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models. Vaccine. 2006 May 08; 24(19):4247-59. PMID: 16216395.
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    74. Small HJ, Neil DM, Taylor AC, Bateman K, Coombs GH. A parasitic scuticociliate infection in the Norway lobster (Nephrops norvegicus). J Invertebr Pathol. 2005 Oct; 90(2):108-17. PMID: 16216262.
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    75. Bradley PJ, Ward C, Cheng SJ, Alexander DL, Coller S, Coombs GH, Dunn JD, Ferguson DJ, Sanderson SJ, Wastling JM, Boothroyd JC. Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondii. J Biol Chem. 2005 Oct 07; 280(40):34245-58. PMID: 16002398.
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    76. Lamour N, Rivière L, Coustou V, Coombs GH, Barrett MP, Bringaud F. Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose. J Biol Chem. 2005 Mar 25; 280(12):11902-10. PMID: 15665328.
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    77. Besteiro S, Coombs GH, Mottram JC. A potential role for ICP, a Leishmanial inhibitor of cysteine peptidases, in the interaction between host and parasite. Mol Microbiol. 2004 Dec; 54(5):1224-36. PMID: 15554964; PMCID: PMC2244714.
    78. Juliano MA, Brooks DR, Selzer PM, Pandolfo HL, Judice WA, Juliano L, Meldal M, Sanderson SJ, Mottram JC, Coombs GH. Differences in substrate specificities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes. Eur J Biochem. 2004 Sep; 271(18):3704-14. PMID: 15355348.
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    79. Cameron P, McGachy A, Anderson M, Paul A, Coombs GH, Mottram JC, Alexander J, Plevin R. Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway. J Immunol. 2004 Sep 01; 173(5):3297-304. PMID: 15322192.
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    80. Mottram JC, Coombs GH, Alexander J. Cysteine peptidases as virulence factors of Leishmania. Curr Opin Microbiol. 2004 Aug; 7(4):375-81. PMID: 15358255.
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    81. Denton H, McGregor JC, Coombs GH. Reduction of anti-leishmanial pentavalent antimonial drugs by a parasite-specific thiol-dependent reductase, TDR1. Biochem J. 2004 Jul 15; 381(Pt 2):405-12. PMID: 15056070; PMCID: PMC1133846.
    82. Denise H, Coombs GH, Mottram JC. Generation of Leishmania mutants lacking antibiotic resistance genes using a versatile hit-and-run targeting strategy. FEMS Microbiol Lett. 2004 Jun 01; 235(1):89-94. PMID: 15158266.
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    83. Tornøe CW, Sanderson SJ, Mottram JC, Coombs GH, Meldal M. Combinatorial library of peptidotriazoles: identification of [1,2,3]-triazole inhibitors against a recombinant Leishmania mexicana cysteine protease. J Comb Chem. 2004 May-Jun; 6(3):312-24. PMID: 15132590.
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    84. Judice WA, Puzer L, Cotrin SS, Carmona AK, Coombs GH, Juliano L, Juliano MA. Carboxydipeptidase activities of recombinant cysteine peptidases. Cruzain of Trypanosoma cruzi and CPB of Leishmania mexicana. Eur J Biochem. 2004 Mar; 271(5):1046-53. PMID: 15009216.
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    85. Coombs GH, Westrop GD, Suchan P, Puzova G, Hirt RP, Embley TM, Mottram JC, Müller S. The amitochondriate eukaryote Trichomonas vaginalis contains a divergent thioredoxin-linked peroxiredoxin antioxidant system. J Biol Chem. 2004 Feb 13; 279(7):5249-56. PMID: 14630923.
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    86. Croft SL, Coombs GH. Leishmaniasis--current chemotherapy and recent advances in the search for novel drugs. Trends Parasitol. 2003 Nov; 19(11):502-8. PMID: 14580961.
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    87. Buxbaum LU, Denise H, Coombs GH, Alexander J, Mottram JC, Scott P. Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity. J Immunol. 2003 Oct 01; 171(7):3711-7. PMID: 14500670.
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    88. Alphey MS, Williams RA, Mottram JC, Coombs GH, Hunter WN. The crystal structure of Leishmania major 3-mercaptopyruvate sulfurtransferase. A three-domain architecture with a serine protease-like triad at the active site. J Biol Chem. 2003 Nov 28; 278(48):48219-27. PMID: 12952945.
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    89. De Koning HP, Al-Salabi MI, Cohen AM, Coombs GH, Wastling JM. Identification and characterisation of high affinity nucleoside and nucleobase transporters in Toxoplasma gondii. Int J Parasitol. 2003 Jul 30; 33(8):821-31. PMID: 12865082.
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    90. Hirt RP, Lal K, Pinxteren J, Warwicker J, Healy B, Coombs GH, Field MC, Embley TM. Biochemical and genetic evidence for a family of heterotrimeric G-proteins in Trichomonas vaginalis. Mol Biochem Parasitol. 2003 Jul; 129(2):179-89. PMID: 12850262.
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    91. Denise H, McNeil K, Brooks DR, Alexander J, Coombs GH, Mottram JC. Expression of multiple CPB genes encoding cysteine proteases is required for Leishmania mexicana virulence in vivo. Infect Immun. 2003 Jun; 71(6):3190-5. PMID: 12761098; PMCID: PMC155739.
    92. Sanderson SJ, Westrop GD, Scharfstein J, Mottram JC, Coombs GH. Functional conservation of a natural cysteine peptidase inhibitor in protozoan and bacterial pathogens. FEBS Lett. 2003 May 08; 542(1-3):12-6. PMID: 12729889.
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    93. Daneshvar H, Coombs GH, Hagan P, Phillips RS. Leishmania mexicana and Leishmania major: attenuation of wild-type parasites and vaccination with the attenuated lines. J Infect Dis. 2003 May 15; 187(10):1662-8. PMID: 12721947.
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    94. Mottram JC, Helms MJ, Coombs GH, Sajid M. Clan CD cysteine peptidases of parasitic protozoa. Trends Parasitol. 2003 Apr; 19(4):182-7. PMID: 12689649.
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    95. Lillico S, Field MC, Blundell P, Coombs GH, Mottram JC. Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8. Mol Biol Cell. 2003 Mar; 14(3):1182-94. PMID: 12631733; PMCID: PMC151589.
    96. Pollock KG, McNeil KS, Mottram JC, Lyons RE, Brewer JM, Scott P, Coombs GH, Alexander J. The Leishmania mexicana cysteine protease, CPB2.8, induces potent Th2 responses. J Immunol. 2003 Feb 15; 170(4):1746-53. PMID: 12574338.
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    97. Basselin M, Denise H, Coombs GH, Barrett MP. Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion. Antimicrob Agents Chemother. 2002 Dec; 46(12):3731-8. PMID: 12435669; PMCID: PMC132791.
    98. Small HJ, Wilson S, Neil DM, Hagan P, Coombs GH. Detection of the parasitic dinoflagellate Hematodinium in the Norway lobster Nephrops norvegicus by ELISA. Dis Aquat Organ. 2002 Nov 22; 52(2):175-7. PMID: 12542095.
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    99. Williams RA, Kelly SM, Mottram JC, Coombs GH. 3-Mercaptopyruvate sulfurtransferase of Leishmania contains an unusual C-terminal extension and is involved in thioredoxin and antioxidant metabolism. J Biol Chem. 2003 Jan 17; 278(3):1480-6. PMID: 12419809.
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    100. Hirt RP, Müller S, Embley TM, Coombs GH. The diversity and evolution of thioredoxin reductase: new perspectives. Trends Parasitol. 2002 Jul; 18(7):302-8. PMID: 12379950.
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    101. Ellis M, Sharma DK, Hilley JD, Coombs GH, Mottram JC. Processing and trafficking of Leishmania mexicana GP63. Analysis using GP18 mutants deficient in glycosylphosphatidylinositol protein anchoring. J Biol Chem. 2002 Aug 02; 277(31):27968-74. PMID: 12029085.
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    102. St Hilaire PM, Alves LC, Herrera F, Renil M, Sanderson SJ, Mottram JC, Coombs GH, Juliano MA, Juliano L, Arevalo J, Meldal M. Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B. J Med Chem. 2002 May 09; 45(10):1971-82. PMID: 11985465.
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    103. Coombs GH, Müller S. Recent advances in the search for new anti-coccidial drugs. Int J Parasitol. 2002 May; 32(5):497-508. PMID: 11943222.
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    104. Roberts CW, Roberts F, Lyons RE, Kirisits MJ, Mui EJ, Finnerty J, Johnson JJ, Ferguson DJ, Coggins JR, Krell T, Coombs GH, Milhous WK, Kyle DE, Tzipori S, Barnwell J, Dame JB, Carlton J, McLeod R. The shikimate pathway and its branches in apicomplexan parasites. J Infect Dis. 2002 Feb 15; 185 Suppl 1:S25-36. PMID: 11865437.
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    105. Cohen AM, Rumpel K, Coombs GH, Wastling JM. Characterisation of global protein expression by two-dimensional electrophoresis and mass spectrometry: proteomics of Toxoplasma gondii. Int J Parasitol. 2002 Jan; 32(1):39-51. PMID: 11796121.
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    106. Coombs GH, Goldberg DE, Klemba M, Berry C, Kay J, Mottram JC. Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets. Trends Parasitol. 2001 Nov; 17(11):532-7. PMID: 11872398.
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    107. Brooks DR, Denise H, Westrop GD, Coombs GH, Mottram JC. The stage-regulated expression of Leishmania mexicana CPB cysteine proteases is mediated by an intercistronic sequence element. J Biol Chem. 2001 Dec 14; 276(50):47061-9. PMID: 11592967.
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    108. Stentifor GD, Neil DM, Coombs GH. Development and application of an immunoassay diagnostic technique for studying Hematodinium infections in Nephrops norvegicus populations. Dis Aquat Organ. 2001 Oct 08; 46(3):223-9. PMID: 11710557.
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    109. Alves LC, Melo RL, Cezari MH, Sanderson SJ, Mottram JC, Coombs GH, Juliano L, Juliano MA. Analysis of the S(2) subsite specificities of the recombinant cysteine proteinases CPB of Leishmania mexicana, and cruzain of Trypanosoma cruzi, using fluorescent substrates containing non-natural basic amino acids. Mol Biochem Parasitol. 2001 Oct; 117(2):137-43. PMID: 11606223.
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    110. Graven A, St Hilaire PM, Sanderson SJ, Mottram JC, Coombs GH, Meldal M. Combinatorial library of peptide isosters based on Diels-Alder reactions: identification of novel inhibitors against a recombinant cysteine protease from Leishmania mexicana. J Comb Chem. 2001 Sep-Oct; 3(5):441-52. PMID: 11549362.
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    111. Alves LC, Judice WA, St Hilaire PM, Meldal M, Sanderson SJ, Mottram JC, Coombs GH, Juliano L, Juliano MA. Substrate specificity of recombinant cysteine proteinase, CPB, of Leishmania mexicana. Mol Biochem Parasitol. 2001 Aug; 116(1):1-9. PMID: 11463460.
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    112. Coombs GH, Mottram JC. Trifluoromethionine, a prodrug designed against methionine gamma-lyase-containing pathogens, has efficacy in vitro and in vivo against Trichomonas vaginalis. Antimicrob Agents Chemother. 2001 Jun; 45(6):1743-5. PMID: 11353620; PMCID: PMC90540.
    113. Müller S, Coombs GH, Walter RD. Targeting polyamines of parasitic protozoa in chemotherapy. Trends Parasitol. 2001 May; 17(5):242-9. PMID: 11323309.
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    114. Alves LC, St Hilaire PM, Meldal M, Sanderson SJ, Mottram JC, Coombs GH, Juliano L, Juliano MA. Identification of peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexicana. Mol Biochem Parasitol. 2001 Apr 25; 114(1):81-8. PMID: 11356516.
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    115. Alves LC, Melo RL, Sanderson SJ, Mottram JC, Coombs GH, Caliendo G, Santagada V, Juliano L, Juliano MA. S1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids. Eur J Biochem. 2001 Mar; 268(5):1206-12. PMID: 11231271.
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    116. Sharma DK, Hilley JD, Bangs JD, Coombs GH, Mottram JC, Menon AK. Soluble GPI8 restores glycosylphosphatidylinositol anchoring in a trypanosome cell-free system depleted of lumenal endoplasmic reticulum proteins. Biochem J. 2000 Nov 01; 351 Pt 3:717-22. PMID: 11042127; PMCID: PMC1221412.
    117. Brooks DR, Tetley L, Coombs GH, Mottram JC. Processing and trafficking of cysteine proteases in Leishmania mexicana. J Cell Sci. 2000 Nov; 113 ( Pt 22):4035-41. PMID: 11058090.
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    118. Frame MJ, Mottram JC, Coombs GH. Analysis of the roles of cysteine proteinases of Leishmania mexicana in the host-parasite interaction. Parasitology. 2000 Oct; 121 ( Pt 4):367-77. PMID: 11072899.
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    119. Stentiford GD, Neil DM, Coombs GH. Alterations in the biochemistry and ultrastructure of the deep abdominal flexor muscle of the norway lobster Nephrops norvegicus during infection by a parasitic dinoflagellate of the genus Hematodinium. Dis Aquat Organ. 2000 Aug 31; 42(2):133-41. PMID: 11023252.
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    120. St Hilaire PM, Alves LC, Sanderson SJ, Mottram JC, Juliano MA, Juliano L, Coombs GH, Meldal M. The substrate specificity of a recombinant cysteine protease from Leishmania mexicana: application of a combinatorial peptide library approach. Chembiochem. 2000 Aug 18; 1(2):115-22. PMID: 11828405.
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    121. Basselin M, Coombs GH, Barrett MP. Putrescine and spermidine transport in Leishmania. Mol Biochem Parasitol. 2000 Jun; 109(1):37-46. PMID: 10924755.
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    122. Brooks DR, McCulloch R, Coombs GH, Mottram JC. Stable transformation of trypanosomatids through targeted chromosomal integration of the selectable marker gene encoding blasticidin S deaminase. FEMS Microbiol Lett. 2000 May 15; 186(2):287-91. PMID: 10802186.
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    123. Sanderson SJ, Pollock KG, Hilley JD, Meldal M, Hilaire PS, Juliano MA, Juliano L, Mottram JC, Coombs GH. Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana. Biochem J. 2000 Apr 15; 347(Pt 2):383-8. PMID: 10749667; PMCID: PMC1220970.
    124. Hilley JD, Zawadzki JL, McConville MJ, Coombs GH, Mottram JC. Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins. Mol Biol Cell. 2000 Apr; 11(4):1183-95. PMID: 10749923; PMCID: PMC14840.
    125. Krauth-Siegel RL, Coombs GH. Enzymes of parasite thiol metabolism as drug targets. Parasitol Today. 1999 Oct; 15(10):404-9. PMID: 10481152.
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    126. Vickerman K, Coombs GH. Protozoan paradigms for cell biology. J Cell Sci. 1999 Sep; 112 ( Pt 17):2797-8. PMID: 10452736.
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    127. Barrett MP, Mottram JC, Coombs GH. Recent advances in identifying and validating drug targets in trypanosomes and leishmanias. Trends Microbiol. 1999 Feb; 7(2):82-8. PMID: 10081086.
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    128. Alexander J, Coombs GH, Mottram JC. Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a Th1 response. J Immunol. 1998 Dec 15; 161(12):6794-801. PMID: 9862710.
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    129. Tetley L, Brown SM, McDonald V, Coombs GH. Ultrastructural analysis of the sporozoite of Cryptosporidium parvum. Microbiology. 1998 Dec; 144 ( Pt 12):3249-55. PMID: 9884216.
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    130. Mottram JC, Coombs GH. Leishmania cysteine proteinases: virulence factors in quest of a function-reply. Parasitol Today. 1998 Dec; 14(6):251-2. PMID: 17040772.
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    131. Zawadzki J, Scholz C, Currie G, Coombs GH, McConville MJ. The glycoinositolphospholipids from Leishmania panamensis contain unusual glycan and lipid moieties. J Mol Biol. 1998 Sep 18; 282(2):287-99. PMID: 9735288.
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    132. Mottram JC, Brooks DR, Coombs GH. Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions. Curr Opin Microbiol. 1998 Aug; 1(4):455-60. PMID: 10066510.
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    133. Roberts F, Roberts CW, Johnson JJ, Kyle DE, Krell T, Coggins JR, Coombs GH, Milhous WK, Tzipori S, Ferguson DJ, Chakrabarti D, McLeod R. Evidence for the shikimate pathway in apicomplexan parasites. Nature. 1998 Jun 25; 393(6687):801-5. PMID: 9655396.
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    134. McKie AE, Edlind T, Walker J, Mottram JC, Coombs GH. The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5'-phosphate-dependent enzymes. J Biol Chem. 1998 Mar 06; 273(10):5549-56. PMID: 9488680.
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    135. Bart G, Frame MJ, Carter R, Coombs GH, Mottram JC. Cathepsin B-like cysteine proteinase-deficient mutants of Leishmania mexicana. Mol Biochem Parasitol. 1997 Sep; 88(1-2):53-61. PMID: 9274867.
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    136. Mottram JC, Frame MJ, Brooks DR, Tetley L, Hutchison JE, Souza AE, Coombs GH. The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences. J Biol Chem. 1997 May 30; 272(22):14285-93. PMID: 9162063.
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    137. Irvine JW, North MJ, Coombs GH. Use of inhibitors to identify essential cysteine proteinases of Trichomonas vaginalis. FEMS Microbiol Lett. 1997 Apr 01; 149(1):45-50. PMID: 9103977.
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    138. Coombs GH, Mottram JC. Parasite proteinases and amino acid metabolism: possibilities for chemotherapeutic exploitation. Parasitology. 1997; 114 Suppl:S61-80. PMID: 9309769.
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    139. Coombs GH, Denton H, Brown SM, Thong KW. Biochemistry of the coccidia. Adv Parasitol. 1997; 39:141-226. PMID: 9241816.
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    140. Brown SM, McDonald V, Denton H, Coombs GH. The use of a new viability assay to determine the susceptibility of Cryptosporidium and Eimeria sporozoites to respiratory inhibitors and extremes of pH. FEMS Microbiol Lett. 1996 Sep 01; 142(2-3):203-8. PMID: 8810503.
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    141. Mottram JC, Souza AE, Hutchison JE, Carter R, Frame MJ, Coombs GH. Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):6008-13. PMID: 8650210; PMCID: PMC39179.
    142. Denton H, Roberts CW, Alexander J, Thong KW, Coombs GH. Enzymes of energy metabolism in the bradyzoites and tachyzoites of Toxoplasma gondii. FEMS Microbiol Lett. 1996 Mar 15; 137(1):103-8. PMID: 8935663.
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    143. Denton H, Brown SM, Roberts CW, Alexander J, McDonald V, Thong KW, Coombs GH. Comparison of the phosphofructokinase and pyruvate kinase activities of Cryptosporidium parvum, Eimeria tenella and Toxoplasma gondii. Mol Biochem Parasitol. 1996 Feb-Mar; 76(1-2):23-9. PMID: 8919992.
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    144. Mallinson DJ, Livingstone J, Appleton KM, Lees SJ, Coombs GH, North MJ. Multiple cysteine proteinases of the pathogenic protozoon Tritrichomonas foetus: identification of seven diverse and differentially expressed genes. Microbiology. 1995 Dec; 141 ( Pt 12):3077-85. PMID: 8574401.
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    145. Zuo X, Lockwood BC, Coombs GH. Uptake of amino acids by the parasitic, flagellated protist Trichomonas vaginalis. Microbiology. 1995 Oct; 141 ( Pt 10):2637-42. PMID: 7582024.
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    146. Foreman DT, Martinez Y, Coombs G, Torres A, Kupersztoch YM. TolC and DsbA are needed for the secretion of STB, a heat-stable enterotoxin of Escherichia coli. Mol Microbiol. 1995 Oct; 18(2):237-45. PMID: 8709843.
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    147. Zuo X, Coombs GH. Amino acid consumption by the parasitic, amoeboid protists Entamoeba histolytica and E. invadens. FEMS Microbiol Lett. 1995 Aug 01; 130(2-3):253-8. PMID: 7649448.
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    148. Williams AG, Coombs GH. Multiple protease activities in Giardia intestinalis trophozoites. Int J Parasitol. 1995 Jul; 25(7):771-8. PMID: 7558562.
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    149. Bart G, Coombs GH, Mottram JC. Isolation of lmcpc, a gene encoding a Leishmania mexicana cathepsin-B-like cysteine proteinase. Mol Biochem Parasitol. 1995 Jul; 73(1-2):271-4. PMID: 8577339.
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    150. Scott DA, North MJ, Coombs GH. The pathway of secretion of proteinases in Trichomonas vaginalis. Int J Parasitol. 1995 Jun; 25(6):657-66. PMID: 7657450.
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    151. Scott DA, North MJ, Coombs GH. Trichomonas vaginalis: amoeboid and flagellated forms synthesize similar proteinases. Exp Parasitol. 1995 Mar; 80(2):345-8. PMID: 7895847.
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    152. Robertson CD, Martinez J, Cazzulo JJ, Coombs GH. Analysis of the cysteine proteinases of Leishmania mexicana and Trypanosoma cruzi using specific antisera. FEMS Microbiol Lett. 1994 Dec 01; 124(2):191-4. PMID: 7813888.
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    153. Franke de Cazzulo BM, Martínez J, North MJ, Coombs GH, Cazzulo JJ. Effects of proteinase inhibitors on the growth and differentiation of Trypanosoma cruzi. FEMS Microbiol Lett. 1994 Nov 15; 124(1):81-6. PMID: 8001773.
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    154. Mallinson DJ, Lockwood BC, Coombs GH, North MJ. Identification and molecular cloning of four cysteine proteinase genes from the pathogenic protozoon Trichomonas vaginalis. Microbiology. 1994 Oct; 140 ( Pt 10):2725-35. PMID: 8000542.
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    155. Bates PA, Robertson CD, Coombs GH. Expression of cysteine proteinases by metacyclic promastigotes of Leishmania mexicana. J Eukaryot Microbiol. 1994 May-Jun; 41(3):199-203. PMID: 8049682.
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    156. Souza AE, Bates PA, Coombs GH, Mottram JC. Null mutants for the lmcpa cysteine proteinase gene in Leishmania mexicana. Mol Biochem Parasitol. 1994 Feb; 63(2):213-20. PMID: 8008019.
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    157. Robertson CD, Coombs GH. Multiple high activity cysteine proteases of Leishmania mexicana are encoded by the Imcpb gene array. Microbiology. 1994 Feb; 140 ( Pt 2):417-24. PMID: 8180705.
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    158. Denton H, Thong KW, Coombs GH. Eimeria tenella contains a pyrophosphate-dependent phosphofructokinase and a pyruvate kinase with unusual allosteric regulators. FEMS Microbiol Lett. 1994 Jan 01; 115(1):87-91. PMID: 8125251.
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    159. Robertson CD, Coombs GH. Cathepsin B-like cysteine proteases of Leishmania mexicana. Mol Biochem Parasitol. 1993 Dec; 62(2):271-9. PMID: 8139620.
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    160. Irvine JW, Coombs GH, North MJ. Purification of cysteine proteinases from trichomonads using bacitracin-Sepharose. FEMS Microbiol Lett. 1993 Jun 01; 110(1):113-9. PMID: 8319888.
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    161. Souza AE, Waugh S, Coombs GH, Mottram JC. Characterization of a multi-copy gene for a major stage-specific cysteine proteinase of Leishmania mexicana. FEBS Lett. 1992 Oct 19; 311(2):124-7. PMID: 1397299.
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    162. Bates PA, Robertson CD, Tetley L, Coombs GH. Axenic cultivation and characterization of Leishmania mexicana amastigote-like forms. Parasitology. 1992 Oct; 105 ( Pt 2):193-202. PMID: 1454417.
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    163. Irvine JW, Coombs GH, North MJ. Cystatin-like cysteine proteinase inhibitors of parasitic protozoa. FEMS Microbiol Lett. 1992 Sep 01; 75(1):67-72. PMID: 1526466.
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    164. Hunter CA, Lockwood BC, Coombs GH. Hydrolysis of L-leucine methyl ester by Leishmania mexicana mexicana amastigote cysteine proteinases. Int J Parasitol. 1992 Sep; 22(6):711-7. PMID: 1428504.
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    165. Robertson CD, Coombs GH. Stage-specific proteinases of Leishmania mexicana mexicana promastigotes. FEMS Microbiol Lett. 1992 Jul 01; 73(1-2):127-32. PMID: 1521760.
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    166. Mottram JC, Robertson CD, Coombs GH, Barry JD. A developmentally regulated cysteine proteinase gene of Leishmania mexicana. Mol Microbiol. 1992 Jul; 6(14):1925-32. PMID: 1508041.
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    167. Lockwood BC, Coombs GH. Purification and characterization of methionine gamma-lyase from Trichomonas vaginalis. Biochem J. 1991 Nov 01; 279 ( Pt 3):675-82. PMID: 1953661; PMCID: PMC1151498.
    168. Meade JC, Coombs GH, Mottram JC, Steele PE, Stringer JR. Conservation of cation-transporting ATPase genes in Leishmania. Mol Biochem Parasitol. 1991 Mar; 45(1):29-38. PMID: 1828863.
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    169. Robertson CD, Coombs GH. Characterisation of three groups of cysteine proteinases in the amastigotes of Leishmania mexicana mexicana. Mol Biochem Parasitol. 1990 Sep-Oct; 42(2):269-76. PMID: 2270108.
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    170. North MJ, Mottram JC, Coombs GH. Cysteine proteinases of parasitic protozoa. Parasitol Today. 1990 Aug; 6(8):270-5. PMID: 15463360.
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    171. Coombs GH, Wolf CR, Morrison VM, Craft JA. Changes in hepatic xenobiotic-metabolising enzymes in mouse liver following infection with Leishmania donovani. Mol Biochem Parasitol. 1990 Jun; 41(1):17-24. PMID: 2117255.
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    172. Robertson CD, North MJ, Lockwood BC, Coombs GH. Analysis of the proteinases of Trypanosoma brucei. J Gen Microbiol. 1990 May; 136(5):921-5. PMID: 2199606.
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    173. North MJ, Robertson CD, Coombs GH. The specificity of trichomonad cysteine proteinases analysed using fluorogenic substrates and specific inhibitors. Mol Biochem Parasitol. 1990 Mar; 39(2):183-93. PMID: 2320056.
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    174. Mottram JC, North MJ, Barry JD, Coombs GH. A cysteine proteinase cDNA from Trypanosoma brucei predicts an enzyme with an unusual C-terminal extension. FEBS Lett. 1989 Dec 04; 258(2):211-5. PMID: 2599086.
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    175. Mallinson DJ, Lackie JM, Coombs GH. The oxidative response of rabbit peritoneal neutrophils to leishmanias and other trypanosomatids. Int J Parasitol. 1989 Sep; 19(6):639-45. PMID: 2509389.
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    176. Mallinson DJ, Coombs GH. Interaction of leishmania metacyclics with macrophages. Int J Parasitol. 1989 Sep; 19(6):647-56. PMID: 2807719.
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    177. Mallinson DJ, Coombs GH. Biochemical characteristics of the metacyclic forms of Leishmania major and L. mexicana mexicana. Parasitology. 1989 Feb; 98 ( Pt 1):7-15. PMID: 2717219.
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    178. Lockwood BC, North MJ, Coombs GH. The release of hydrolases from Trichomonas vaginalis and Tritrichomonas foetus. Mol Biochem Parasitol. 1988 Aug; 30(2):135-42. PMID: 3140008.
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    179. Hunter CA, Dolan TF, Coombs GH, Baillie AJ. Vesicular systems (niosomes and liposomes) for delivery of sodium stibogluconate in experimental murine visceral leishmaniasis. J Pharm Pharmacol. 1988 Mar; 40(3):161-5. PMID: 2899143.
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    180. Hassan HF, Coombs GH. Purine and pyrimidine metabolism in parasitic protozoa. FEMS Microbiol Rev. 1988 Feb; 4(1):47-83. PMID: 3078769.
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    181. Baillie AJ, Coombs GH, Dolan TF, Hunter CA, Laakso T, Sjöholm I, Stjärnkvist P. Biodegradable microspheres: polyacryl starch microparticles as a delivery system for the antileishmanial drug, sodium stibogluconate. J Pharm Pharmacol. 1987 Oct; 39(10):832-5. PMID: 2891821.
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    182. Hassan HF, Coombs GH. Purine salvage by Acanthamoeba castellanii. Int J Parasitol. 1987 Oct; 17(7):1267-72. PMID: 3429118.
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    183. Scott DA, Coombs GH, Sanderson BE. Effects of methotrexate and other antifolates on the growth and dihydrofolate reductase activity of Leishmania promastigotes. Biochem Pharmacol. 1987 Jun 15; 36(12):2043-5. PMID: 3593407.
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    184. Lockwood BC, North MJ, Scott KI, Bremner AF, Coombs GH. The use of a highly sensitive electrophoretic method to compare the proteinases of trichomonads. Mol Biochem Parasitol. 1987 May; 24(1):89-95. PMID: 3302703.
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    185. Hassan HF, Coombs GH. Phosphomonoesterases of Leishmania mexicana mexicana and other flagellates. Mol Biochem Parasitol. 1987 Apr; 23(3):285-96. PMID: 3037369.
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    186. Thong KW, Coombs GH. Trichomonas species: homocysteine desulphurase and serine sulphydrase activities. Exp Parasitol. 1987 Apr; 63(2):143-51. PMID: 3494628.
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    187. Thong KW, Coombs GH, Sanderson BE. L-methionine catabolism in trichomonads. Mol Biochem Parasitol. 1987 Apr; 23(3):223-31. PMID: 3496535.
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    188. Thong KW, Coombs GH. The effects of inhibitors of sulphur-containing amino acid metabolism on the growth of Trichomonas vaginalis in vitro. J Antimicrob Chemother. 1987 Apr; 19(4):429-37. PMID: 3495529.
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    189. Scott DA, Coombs GH, Sanderson BE. Folate utilisation by Leishmania species and the identification of intracellular derivatives and folate-metabolising enzymes. Mol Biochem Parasitol. 1987 Mar; 23(2):139-49. PMID: 3574356.
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    190. Coombs GH. Intermediary metabolism in parasitic protozoa. Int J Parasitol. 1987 Feb; 17(1):97-104. PMID: 3294645.
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    191. Thong KW, Coombs GH, Sanderson BE. S-adenosylmethionine and transmethylation reactions in trichomonads. Parasitol Res. 1987; 73(3):193-8. PMID: 3108875.
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    192. Thong KW, Coombs GH. Comparative study of ferredoxin-linked and oxygen-metabolizing enzymes of trichomonads. Comp Biochem Physiol B. 1987; 87(3):637-41. PMID: 3497772.
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    193. Hassan HF, Phillips RS, Coombs GH. Purine-metabolizing enzymes in Babesia divergens. Parasitol Res. 1987; 73(2):121-5. PMID: 3033631.
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    194. Pupkis MF, Tetley L, Coombs GH. Leishmania mexicana: amastigote hydrolases in unusual lysosomes. Exp Parasitol. 1986 Aug; 62(1):29-39. PMID: 3522261.
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    195. Baillie AJ, Coombs GH, Dolan TF, Laurie J. Non-ionic surfactant vesicles, niosomes, as a delivery system for the anti-leishmanial drug, sodium stibogluconate. J Pharm Pharmacol. 1986 Jul; 38(7):502-5. PMID: 2875149.
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    196. North MJ, Lockwood BC, Bremner AF, Coombs GH. Polyamine biosynthesis in trichomonads. Mol Biochem Parasitol. 1986 Jun; 19(3):241-9. PMID: 3090433.
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    197. Hassan HF, Coombs GH. Purine-metabolising enzymes in Entamoeba histolytica. Mol Biochem Parasitol. 1986 Apr; 19(1):19-26. PMID: 2872591.
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    198. Coombs GH, Tetley L, Moss VA, Vickerman K. Three dimensional structure of the Leishmania amastigote as revealed by computer-aided reconstruction from serial sections. Parasitology. 1986 Feb; 92 ( Pt 1):13-23. PMID: 3754324.
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    199. Pupkis MF, Coombs GH. Electrophoretic analysis of the polypeptides of Leishmania amastigotes and promastigotes. Comp Biochem Physiol B. 1986; 83(3):629-32. PMID: 3956174.
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    200. Tetley L, Coombs GH, Vickerman K. The surface membrane of Leishmania mexicana mexicana: comparison of amastigote and promastigote using freeze-fracture cytochemistry. Z Parasitenkd. 1986; 72(3):281-92. PMID: 3716538.
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    201. Thong KW, Coombs GH, Sanderson BE. S-Adenosylhomocysteine hydrolase activity in Trichomonas vaginalis and other trichomonads. Mol Biochem Parasitol. 1985 Oct; 17(1):35-44. PMID: 3932851.
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    202. Coombs GH, Sanderson BE. Amine production by Leishmania mexicana. Ann Trop Med Parasitol. 1985 Aug; 79(4):409-15. PMID: 4073994.
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    203. Mottram JC, Coombs GH. Leishmania mexicana: subcellular distribution of enzymes in amastigotes and promastigotes. Exp Parasitol. 1985 Jun; 59(3):265-74. PMID: 3158538.
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    204. Mottram JC, Coombs GH. Leishmania mexicana: enzyme activities of amastigotes and promastigotes and their inhibition by antimonials and arsenicals. Exp Parasitol. 1985 Apr; 59(2):151-60. PMID: 2982638.
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    205. Hassan HF, Coombs GH. Leishmania mexicana: purine-metabolizing enzymes of amastigotes and promastigotes. Exp Parasitol. 1985 Apr; 59(2):139-50. PMID: 2982637.
      View in: PubMed
    206. Mottram JC, Coombs GH. Purification of particulate malate dehydrogenase and phosphoenolpyruvate carboxykinase from Leishmania mexicana mexicana. Biochim Biophys Acta. 1985 Mar 01; 827(3):310-9. PMID: 3970941.
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    207. Hassan HF, Mottram JC, Coombs GH. Subcellular localisation of purine-metabolising enzymes in Leishmania mexicana mexicana. Comp Biochem Physiol B. 1985; 81(4):1037-40. PMID: 4042622.
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    208. Hassan HF, Coombs GH. Purine phosphoribosyltransferases of Leishmania mexicana mexicana and other flagellate protozoa. Comp Biochem Physiol B. 1985; 82(4):773-9. PMID: 3937660.
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    209. Lockwood BC, North MJ, Coombs GH. Trichomonas vaginalis, Tritrichomonas foetus, and Trichomitus batrachorum: comparative proteolytic activity. Exp Parasitol. 1984 Dec; 58(3):245-53. PMID: 6389167.
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    210. Pupkis MF, Coombs GH. Purification and characterization of proteolytic enzymes of Leishmania mexicana mexicana amastigotes and promastigotes. J Gen Microbiol. 1984 Sep; 130(9):2375-83. PMID: 6389769.
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    211. Coombs GH, Baxter J. Inhibition of Leishmania amastigote growth by antipain and leupeptin. Ann Trop Med Parasitol. 1984 Feb; 78(1):21-4. PMID: 6721611.
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    212. North MJ, Coombs GH, Barry JD. A comparative study of the proteolytic enzymes of Trypanosoma brucei, T. equiperdum, T. evansi, T. vivax, Leishmania tarentolae and Crithidia fasciculata. Mol Biochem Parasitol. 1983 Oct; 9(2):161-80. PMID: 6366547.
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    213. Coombs GH, Hart DT, Capaldo J. Leishmania mexicana: drug sensitivities of promastigotes and transforming amastigotes. J Antimicrob Chemother. 1983 Feb; 11(2):151-62. PMID: 6833171.
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    214. Coombs GH, North MJ. An analysis of the proteinases of Trichomonas vaginalis by polyacrylamide gel electrophoresis. Parasitology. 1983 Feb; 86 (Pt 1):1-6. PMID: 6340036.
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    215. Hart DT, Coombs GH. Leishmania mexicana: energy metabolism of amastigotes and promastigotes. Exp Parasitol. 1982 Dec; 54(3):397-409. PMID: 7151947.
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    216. Gero AM, Coombs GH. Pyrimidine biosynthetic enzymes in Babesia hylomysci. Int J Parasitol. 1982 Oct; 12(5):377-82. PMID: 6292120.
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    217. Gero AM, Coombs GH. Leishmania mexicana: conversion of dihydroorotate to orotate in amastigotes and promastigotes. Exp Parasitol. 1982 Oct; 54(2):185-95. PMID: 6290253.
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    218. Coombs GH, Craft JA, Hart DT. A comparative study of Leishmania mexicana amastigotes and promastigotes. Enzyme activities and subcellular locations. Mol Biochem Parasitol. 1982 Mar; 5(3):199-211. PMID: 6211617.
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    219. Coombs GH. Proteinases of Leishmania mexicana and other flagellate protozoa. Parasitology. 1982 Feb; 84(1):149-55. PMID: 6460959.
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    220. Hart DT, Vickerman K, Coombs GH. Respiration of Leishmania mexicana amastigotes and promastigotes. Mol Biochem Parasitol. 1981 Nov; 4(1-2):39-51. PMID: 7322186.
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    221. Hart DT, Coombs GH. The effects of carbon dioxide and oxygen upon the growth and in vitro transformation of Leishmania mexicana mexicana. Mol Biochem Parasitol. 1981 Nov; 4(1-2):117-27. PMID: 6798439.
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    222. North MJ, Coombs GH. Proteinases of Leishmania mexicana amastigotes and promastigotes: analysis by gel electrophoresis. Mol Biochem Parasitol. 1981 Sep; 3(5):293-300. PMID: 7029274.
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    223. Hart DT, Vickerman K, Coombs GH. A quick, simple method for purifying Leishmania mexicana amastigotes in large numbers. Parasitology. 1981 Jun; 82(Pt 3):345-55. PMID: 7243344.
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    224. Gero AM, Tetley K, Coombs GH, Phillips RS. Dihydroorotate dehydrogenase, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase in Plasmodium falciparum. Trans R Soc Trop Med Hyg. 1981; 75(5):719-20. PMID: 6277049.
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    225. Gero AM, Coombs GH. Orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase in two parasitic kinetoplastid flagellates. FEBS Lett. 1980 Aug 25; 118(1):130-2. PMID: 7409187.
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    226. Mazen L, Gull K, Coombs GH, Gutteridge WE. Proceedings: Ultrastructural investigation of Plasmodium chabaudi: schizogony and the effect of pyrimethamine. Parasitology. 1974 Oct; 69(2):x-xi. PMID: 4419498.
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    227. Coombs GH, Rabin BR. The flagyl analogue of nicotinamide adenine dinucleotide. FEBS Lett. 1974 Jun 01; 42(2):231-5. PMID: 4153117.
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    228. Coombs GH, Rabin BR. Flagyl and reduced nicotinamide adenine dinucleotide. FEBS Lett. 1974 May 15; 42(1):105-7. PMID: 4368731.
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