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Professor Kwang Poo Chang

TitleProfessor
InstitutionChicago Medical School/Rosalind Franklin University of Medicine and Science
DepartmentMicrobiology/Immunology
AddressNorth Chicago 60064
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    Leishmania and leishmaniasis


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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chang KP, Kolli BK. New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives. Parasit Vectors. 2016 Jul 13; 9(1):396. PMID: 27412129; PMCID: PMC4942964.
    2. Al-Qahtani A, Alkahtani S, Kolli B, Tripathi P, Dutta S, Al-Kahtane AA, Jiang XJ, Ng DK, Chang KP. Aminophthalocyanine-Mediated Photodynamic Inactivation of Leishmania tropica. Antimicrob Agents Chemother. 2016 Apr; 60(4):2003-11. PMID: 26824938; PMCID: PMC4808211 [Available on 10/01/16].
    3. Lun ZR, Wu MS, Chen YF, Wang JY, Zhou XN, Liao LF, Chen JP, Chow LM, Chang KP. Visceral Leishmaniasis in China: an Endemic Disease under Control. Clin Microbiol Rev. 2015 Oct; 28(4):987-1004. PMID: 26354822; PMCID: PMC4575399 [Available on 10/01/16].
    4. Shio MT, Christian JG, Jung JY, Chang KP, Olivier M. PKC/ROS-Mediated NLRP3 Inflammasome Activation Is Attenuated by Leishmania Zinc-Metalloprotease during Infection. PLoS Negl Trop Dis. 2015; 9(6):e0003868. PMID: 26114647; PMCID: PMC4482689.
    5. Jecna L, Dostalova A, Wilson R, Seblova V, Chang KP, Bates PA, Volf P. The role of surface glycoconjugates in Leishmania midgut attachment examined by competitive binding assays and experimental development in sand flies. Parasitology. 2013 Jul; 140(8):1026-32. PMID: 23611086.
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    6. Dutta S, Chang C, Kolli BK, Sassa S, Yousef M, Showe M, Showe L, Chang KP. Delta-aminolevulinate-induced host-parasite porphyric disparity for selective photolysis of transgenic Leishmania in the phagolysosomes of mononuclear phagocytes: a potential novel platform for vaccine delivery. Eukaryot Cell. 2012 Apr; 11(4):430-41. PMID: 22307976; PMCID: PMC3318301.
    7. Majumder HK, de Souza W, Chang KP. Target Identification and Intervention Strategies against Kinetoplastid Protozoan Parasites. Mol Biol Int. 2011; 2011:185413. PMID: 22091397; PMCID: PMC3196916.
    8. Dutta S, Ongarora BG, Li H, Vicente Mda G, Kolli BK, Chang KP. Intracellular targeting specificity of novel phthalocyanines assessed in a host-parasite model for developing potential photodynamic medicine. PLoS One. 2011; 6(6):e20786. PMID: 21673971; PMCID: PMC3108980.
    9. Wang Y, Chen Y, Xin L, Beverley SM, Carlsen ED, Popov V, Chang KP, Wang M, Soong L. Differential microbicidal effects of human histone proteins H2A and H2B on Leishmania promastigotes and amastigotes. Infect Immun. 2011 Mar; 79(3):1124-33. PMID: 21189319; PMCID: PMC3067510.
    10. Varela M RE, Muñoz DL, Robledo SM, Kolli BK, Dutta S, Chang KP, Muskus C. Leishmania (Viannia) panamensis: an in vitro assay using the expression of GFP for screening of antileishmanial drug. Exp Parasitol. 2009 Jun; 122(2):134-9. PMID: 19303871; PMCID: PMC3640980.
    11. Mehta SR, Huang R, Yang M, Zhang XQ, Kolli B, Chang KP, Hoffman RM, Goto Y, Badaro R, Schooley RT. Real-time in vivo green fluorescent protein imaging of a murine leishmaniasis model as a new tool for Leishmania vaccine and drug discovery. Clin Vaccine Immunol. 2008 Dec; 15(12):1764-70. PMID: 18945882; PMCID: PMC2593180.
    12. Culha G, Uzun S, Ozcan K, Memisoglu HR, Chang KP. Comparison of conventional and polymerase chain reaction diagnostic techniques for leishmaniasis in the endemic region of Adana, Turkey. Int J Dermatol. 2006 May; 45(5):569-72. PMID: 16700794.
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    13. Thiakaki M, Kolli B, Chang KP, Soteriadou K. Down-regulation of gp63 level in Leishmania amazonensis promastigotes reduces their infectivity in BALB/c mice. Microbes Infect. 2006 May; 8(6):1455-63. PMID: 16698300.
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    14. Thiakaki M, Rohousova I, Volfova V, Volf P, Chang KP, Soteriadou K. Sand fly specificity of saliva-mediated protective immunity in Leishmania amazonensis-BALB/c mouse model. Microbes Infect. 2005 Apr; 7(4):760-6. PMID: 15866511.
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    15. Toz SO, Chang KP, Ozbel Y, Alkan MZ. Diagnostic value of rK39 dipstick in zoonotic visceral leishmaniasis in Turkey. J Parasitol. 2004 Dec; 90(6):1484-6. PMID: 15715249.
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    16. Chang KP, Reed SG, McGwire BS, Soong L. Leishmania model for microbial virulence: the relevance of parasite multiplication and pathoantigenicity. Acta Trop. 2003 Mar; 85(3):375-90. PMID: 12659975.
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    17. McGwire BS, Chang KP, Engman DM. Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63. Infect Immun. 2003 Feb; 71(2):1008-10. PMID: 12540585; PMCID: PMC145380.
    18. Rosypal AC, Troy GC, Zajac AM, Duncan RB, Waki K, Chang KP, Lindsay DS. Emergence of zoonotic canine leishmaniasis in the United States: isolation and immunohistochemical detection of Leishmania infantum from foxhounds from Virginia. J Eukaryot Microbiol. 2003; 50 Suppl:691-3. PMID: 14736222.
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    19. Svobodová M, Sádlová J, Chang KP, Volf P. Short report: distribution and feeding preference of the sand flies Phlebotomus sergenti and P. papatasi in a cutaneous leishmaniasis focus in Sanliurfa, Turkey. Am J Trop Med Hyg. 2003 Jan; 68(1):6-9. PMID: 12556140.
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    20. Chan MM, Bulinski JC, Chang KP, Fong D. A microplate assay for Leishmania amazonensis promastigotes expressing multimeric green fluorescent protein. Parasitol Res. 2003 Mar; 89(4):266-71. PMID: 12632163.
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    21. Hatabu T, Matsumoto Y, Kawazu S, Nakamura Y, Kamio T, Lu HG, Chang KP, Hashiguchi Y, Kano S, Onodera T, Matsumoto Y. The expression system of biologically active canine interleukin-8 in Leishmania promastigotes. Parasitol Int. 2002 Mar; 51(1):63-71. PMID: 11880228.
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    22. Volf P, Ozbel Y, Akkafa F, Svobodová M, Votýpka J, Chang KP. Sand flies (Diptera: Phlebotominae) in Sanliurfa, Turkey: relationship of Phlebotomus sergenti with the epidemic of anthroponotic cutaneous leishmaniasis. J Med Entomol. 2002 Jan; 39(1):12-5. PMID: 11931243.
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    23. Chen DQ, Kolli BK, Yadava N, Lu HG, Gilman-Sachs A, Peterson DA, Chang KP. Episomal expression of specific sense and antisense mRNAs in Leishmania amazonensis: modulation of gp63 level in promastigotes and their infection of macrophages in vitro. Infect Immun. 2000 Jan; 68(1):80-6. PMID: 10603371; PMCID: PMC97104.
    24. Qu JQ, Guan LR, Shulidan I, Zuo XP, Chai JJ, Chen SB, Kawazu S, Katakura K, Matsumoto Y, Reed SG, Chang KP. Rapid screening with a recombinant antigen (rK39) for diagnosis of visceral leishmaniasis using dipstick. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2000; 18(3):155-8. PMID: 12567693.
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    25. Ma Y, Hu XS, Chang KP. [Diagnosis of kala-azar by rK39 dipstick assay]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2000; 18(4):252. PMID: 12567678.
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    26. Brittingham A, Chen G, McGwire BS, Chang KP, Mosser DM. Interaction of Leishmania gp63 with cellular receptors for fibronectin. Infect Immun. 1999 Sep; 67(9):4477-84. PMID: 10456889; PMCID: PMC96767.
    27. Chen DQ, Lu H, Chang KP. Replacement of Leishmania N-acetylglucosamine-1-phosphate transferase gene requires episomal rescue. Mol Biochem Parasitol. 1999 May 25; 100(2):223-7. PMID: 10391384.
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    28. Chang KP, Akman L, Nielsen JS. Leishmania virulence and genetic heterogeneity. Clin Dermatol. 1999 May-Jun; 17(3):269-73. PMID: 10384865.
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    29. Mensa-Wilmot K, Garg N, McGwire BS, Lu HG, Zhong L, Armah DA, LeBowitz JH, Chang KP. Roles of free GPIs in amastigotes of Leishmania. Mol Biochem Parasitol. 1999 Mar 15; 99(1):103-16. PMID: 10215028.
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    30. Chai J, Chang KP, Zuo X, Yan L, Hou Y, Zhang S. [Protective effects of leishmanial antigens against Leishmania infantum infection in Lagurus lagurus]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1999; 17(4):237-40. PMID: 12563775.
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    31. Chakrabarty R, Mukherjee S, Lu HG, McGwire BS, Chang KP, Basu MK. Kinetics of entry of virulent and avirulent strains of Leishmania donovani into macrophages: a possible role of virulence molecules (gp63 and LPG). J Parasitol. 1996 Aug; 82(4):632-5. PMID: 8691373.
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    32. McGwire BS, Chang KP. Posttranslational regulation of a Leishmania HEXXH metalloprotease (gp63). The effects of site-specific mutagenesis of catalytic, zinc binding, N-glycosylation, and glycosyl phosphatidylinositol addition sites on N-terminal end cleavage, intracellular stability, and extracellular exit. J Biol Chem. 1996 Apr 05; 271(14):7903-9. PMID: 8626468.
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    33. Singh S, Gilman-Sachs A, Chang KP, Reed SG. Diagnostic and prognostic value of K39 recombinant antigen in Indian leishmaniasis. J Parasitol. 1995 Dec; 81(6):1000-3. PMID: 8544037.
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    34. Brittingham A, Morrison CJ, McMaster WR, McGwire BS, Chang KP, Mosser DM. Role of the Leishmania surface protease gp63 in complement fixation, cell adhesion, and resistance to complement-mediated lysis. J Immunol. 1995 Sep 15; 155(6):3102-11. PMID: 7673725.
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    35. Aksoy S, Ariturk S, Armstrong MY, Chang KP, Dörtbudak Z, Gottlieb M, Ozcel MA, Richards FF, Western K. The GAP project in southeastern Turkey: the potential for emergence of diseases. Emerg Infect Dis. 1995 Apr-Jun; 1(2):62-3. PMID: 8903163; PMCID: PMC2626833.
    36. Huang M, Albach RA, Chang KP, Tripathi RL, Kemp RG. Cloning and sequencing a putative pyrophosphate-dependent phosphofructokinase gene from Entamoeba histolytica. Biochim Biophys Acta. 1995 Jan 25; 1260(2):215-7. PMID: 7841199.
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    37. Qu JQ, Zhong L, Masoom-Yasinzai M, Abdur-Rab M, Aksu HS, Reed SG, Chang KP, Gilman-Sachs A. Serodiagnosis of Asian leishmaniasis with a recombinant antigen from the repetitive domain of a Leishmania kinesin. Trans R Soc Trop Med Hyg. 1994 Sep-Oct; 88(5):543-5. PMID: 7992333.
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    38. Liu X, Chang KP. N-acetylglucosamine-1-phosphate transferase gene is conserved in five Leishmania spp. and overexpressed due to its amplification in their tunicamycin-resistant variants. Mol Biochem Parasitol. 1993 May; 59(1):177-9. PMID: 8390612.
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    39. Lee ST, Tarn C, Chang KP. Characterization of the switch of kinetoplast DNA minicircle dominance during development and reversion of drug resistance in Leishmania. Mol Biochem Parasitol. 1993 Apr; 58(2):187-203. PMID: 8386802.
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    40. Liu X, Chang KP. The 63-kilobase circular amplicon of tunicamycin-resistant Leishmania amazonensis contains a functional N-acetylglucosamine-1-phosphate transferase gene that can be used as a dominant selectable marker in transfection. Mol Cell Biol. 1992 Sep; 12(9):4112-22. PMID: 1324414; PMCID: PMC360310.
    41. Liu X, Chang KP. Extrachromosomal genetic complementation of surface metalloproteinase (gp63)-deficient Leishmania increases their binding to macrophages. Proc Natl Acad Sci U S A. 1992 Jun 01; 89(11):4991-5. PMID: 1594604; PMCID: PMC49214.
    42. Lee SY, Lee ST, Chang KP. Transkinetoplastidy--a novel phenomenon involving bulk alterations of mitochondrion-kinetoplast DNA of a trypanosomatid protozoan. J Protozool. 1992 Jan-Feb; 39(1):190-6. PMID: 1348540.
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    43. Katakura K, Peng Y, Pithawalla R, Detke S, Chang KP. Tunicamycin-resistant variants from five species of Leishmania contain amplified DNA in extrachromosomal circles of different sizes with a transcriptionally active homologous region. Mol Biochem Parasitol. 1991 Feb; 44(2):233-43. PMID: 1646959.
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    44. Olafson RW, Thomas JR, Ferguson MA, Dwek RA, Chaudhuri M, Chang KP, Rademacher TW. Structures of the N-linked oligosaccharides of Gp63, the major surface glycoprotein, from Leishmania mexicana amazonensis. J Biol Chem. 1990 Jul 25; 265(21):12240-7. PMID: 2373691.
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    45. Chang KP, Chaudhuri G, Fong D. Molecular determinants of Leishmania virulence. Annu Rev Microbiol. 1990; 44:499-529. PMID: 2252392.
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    46. Chaudhuri G, Chaudhuri M, Pan A, Chang KP. Surface acid proteinase (gp63) of Leishmania mexicana. A metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages. J Biol Chem. 1989 May 05; 264(13):7483-9. PMID: 2708373.
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    47. Kink JA, Chang KP. Tunicamycin-resistant Leishmania mexicana amazonensis: expression of virulence associated with an increased activity of N-acetylglucosaminyltransferase and amplification of its presumptive gene. Proc Natl Acad Sci U S A. 1987 Mar; 84(5):1253-7. PMID: 2950522; PMCID: PMC304405.
    48. Chang CS, Inserra TJ, Kink JA, Fong D, Chang KP. Expression and size heterogeneity of a 63 kilodalton membrane glycoprotein during growth and transformation of Leishmania mexicana amazonensis. Mol Biochem Parasitol. 1986 Feb; 18(2):197-210. PMID: 3515177.
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    49. Chang KP, Nacy CA, Pearson RD. Intracellular parasitism of macrophages in leishmaniasis: in vitro systems and their applications. Methods Enzymol. 1986; 132:603-26. PMID: 3821527.
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    50. Chang CS, Chang KP. Monoclonal antibody affinity purification of a Leishmania membrane glycoprotein and its inhibition of leishmania-macrophage binding. Proc Natl Acad Sci U S A. 1986 Jan; 83(1):100-4. PMID: 3079902; PMCID: PMC322799.
    51. Fong D, Chang KP. Changes in tubulin mRNAs during differentiation of a parasitic protozoan Leishmania mexicana. Ann N Y Acad Sci. 1986; 466:129-31. PMID: 3460412.
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    52. Chang CS, Chang KP. Heme requirement and acquisition by extracellular and intracellular stages of Leishmania mexicana amazonensis. Mol Biochem Parasitol. 1985 Sep; 16(3):267-76. PMID: 4058483.
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    53. Kiehlbauch JA, Albach RA, Baum LL, Chang KP. Phagocytosis of Campylobacter jejuni and its intracellular survival in mononuclear phagocytes. Infect Immun. 1985 May; 48(2):446-51. PMID: 3988342; PMCID: PMC261341.
    54. Hu XS, Chang KP. [Immunization of BALB/c mice with cultured amastigotes of Leishmania mexicana amazonensis: protection by gamma-irradiated parasites]. Sichuan Yi Xue Yuan Xue Bao. 1985 Mar; 16(1):1-5. PMID: 4012583.
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    55. Fong D, Wallach M, Keithly J, Melera PW, Chang KP. Differential expression of mRNAs for alpha- and beta-tubulin during differentiation of the parasitic protozoan Leishmania mexicana. Proc Natl Acad Sci U S A. 1984 Sep; 81(18):5782-6. PMID: 6592587; PMCID: PMC391795.
    56. Chang KP. Cellular and molecular mechanisms of intracellular symbiosis in leishmaniasis. Int Rev Cytol Suppl. 1983; 14:267-305. PMID: 6341275.
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    57. Chang KP. Antibody-mediated inhibition of phagocytosis in Leishmania donovani-human phagocyte interactions in vitro. Am J Trop Med Hyg. 1981 Mar; 30(2):334-9. PMID: 7235126.
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    58. Chang KP, Bray RS, Leaney AJ. Infection of mouse macrophages in vitro by sandfly-derived promastigotes of Leishmania mexicana amazonensis. Trans R Soc Trop Med Hyg. 1981; 75(3):475-6. PMID: 7324121.
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    59. Chang KP. Human cutaneous lieshmania in a mouse macrophage line: propagation and isolation of intracellular parasites. Science. 1980 Sep 12; 209(4462):1240-42. PMID: 7403880.
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    60. Chang KP. Leishmania donovani: promastigote--macrophage surface interactions in vitro. Exp Parasitol. 1979 Oct; 48(2):175-89. PMID: 477809.
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    61. Chang KP. Leishmania infection of human skin fibroblasts in vitro: absence of phagolysosomal fusion after induced phagocytosis of promastigotes, and their intracellular transformation. Am J Trop Med Hyg. 1978 Nov; 27(6):1084-96. PMID: 727316.
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    62. Chang KP. Intracellular multiplication of Leishmania donovani during repeated passages in primary cultures of hamster peritoneal macrophages. J Parasitol. 1978 Oct; 64(5):931-3. PMID: 722464.
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    63. Chang KP. Hamster peritoneal macrophages in vitro: substratum adhesion, spreading, phagocytosis and phagolysosome formation. In Vitro. 1978 Aug; 14(8):663-74. PMID: 567621.
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    64. Chang KP, Dwyer DM. Leishmania donovani. Hamster macrophage interactions in vitro: cell entry, intracellular survival, and multiplication of amastigotes. J Exp Med. 1978 Feb 01; 147(2):515-30. PMID: 564391; PMCID: PMC2184486.
    65. Chang KP, Steiger RF, Dave C, Cheng YC. Effects of methylglyoxal bis(ganylhydrazone) on trypanosomatid flagellates: inhibition of growth and nucleoside incorporation in Trypanosoma brucei. J Protozool. 1978 Feb; 25(1):145-9. PMID: 660567.
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    66. Meshnick SR, Chang KP, Cerami A. Heme lysis of the bloodstream forms of Trypanosoma brucei. Biochem Pharmacol. 1977 Oct 15; 26(20):1923-8. PMID: 911346.
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    67. Chang KP. Effects of elevated temperature on the mycetome and symbiotes of the bed bug Cimex lectularius (Heteroptera). J Invertebr Pathol. 1974 May; 23(3):333-40. PMID: 4208302.
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    68. Chang KP, Trager W. Nutritional significance of symbiotic bacteria in two species of hemoflagellates. Science. 1974 Feb 08; 183(4124):531-2. PMID: 4203488.
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    69. Chang KP, Musgrave AJ. Morphology, histochemistry, and ultrastructure of mycetome and its rickettsial symbiotes in Cimex lectularius L. Can J Microbiol. 1973 Sep; 19(9):1075-81. PMID: 4127814.
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    70. Chang KP, Musgrave AJ. Multiple symbiosis in a leafhopper, Helochara communis Fitch (Cicadellidae: Homoptera): envelopes, nucleoids and inclusions of the symbiotes. J Cell Sci. 1972 Jul; 11(1):275-93. PMID: 4341989.
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    71. Chang KP, Musgrave AJ. Ultrastructure of rickettsia-like microorganisms in the midgut of a plant bug, Stenotus binotatus Jak. (Heteroptera: Miridae). Can J Microbiol. 1970 Jul; 16(7):621-2. PMID: 4097197.
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    72. Chang KP, Musgrave AJ. Histochemistry and ultrastructure of the mycetome and its 'symbiotes' in the pear psylla, Psylla pyricola Foerster (Homoptera). Tissue Cell. 1969; 1(4):597-606. PMID: 18631487.
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