Loading...
Header Logo
Keywords
Last Name
Institution

Dr Jonathan Vennerstrom

Title[no position]
Institution[no institution name]
Address[no address]
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wang X, Cal M, Kaiser M, Buckner FS, Lepesheva GI, Sanford AG, Wallick AI, Davis PH, Vennerstrom JL. A new chemotype with promise against Trypanosoma cruzi. Bioorg Med Chem Lett. 2020 Jan 01; 30(1):126778. PMID: 31706668.
      View in: PubMed
    2. Almahmoud S, Wang X, Vennerstrom JL, Zhong HA. Conformational Studies of Glucose Transporter 1 (GLUT1) as an Anticancer Drug Target. Molecules. 2019 Jun 07; 24(11). PMID: 31181707.
      View in: PubMed
    3. Wu J, Wang C, Häberli C, White KL, Shackleford DM, Chen G, Dong Y, Charman SA, Keiser J, Vennerstrom JL. SAR of a new antischistosomal urea carboxylic acid. Bioorg Med Chem Lett. 2018 12 15; 28(23-24):3648-3651. PMID: 30389288.
      View in: PubMed
    4. Alraddadi EA, Lillico R, Vennerstrom JL, Lakowski TM, Miller DW. Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth. Pharmaceutics. 2018 Mar 08; 10(1). PMID: 29518030.
      View in: PubMed
    5. Wu J, Wang C, Leas D, Vargas M, White KL, Shackleford DM, Chen G, Sanford AG, Hemsley RM, Davis PH, Dong Y, Charman SA, Keiser J, Vennerstrom JL. Progress in antischistosomal N,N'-diaryl urea SAR. Bioorg Med Chem Lett. 2018 02 01; 28(3):244-248. PMID: 29317164.
      View in: PubMed
    6. Neville AJ, Zach SJ, Wang X, Larson JJ, Judge AK, Davis LA, Vennerstrom JL, Davis PH. Clinically Available Medicines Demonstrating Anti-Toxoplasma Activity. Antimicrob Agents Chemother. 2015 Dec; 59(12):7161-9. PMID: 26392504.
      View in: PubMed
    7. Keiser J, Panic G, Vargas M, Wang C, Dong Y, Gautam N, Vennerstrom JL. Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal. J Antimicrob Chemother. 2015; 70(6):1788-97. PMID: 25691324.
      View in: PubMed
    8. Cowan N, Dätwyler P, Ernst B, Wang C, Vennerstrom JL, Spangenberg T, Keiser J. Activities of N,N'-Diarylurea MMV665852 analogs against Schistosoma mansoni. Antimicrob Agents Chemother. 2015 Apr; 59(4):1935-41. PMID: 25583726.
      View in: PubMed
    9. Xue J, Wang X, Dong Y, Vennerstrom JL, Xiao SH. Effect of ozonide OZ418 against Schistosoma japonicum harbored in mice. Parasitol Res. 2014 Sep; 113(9):3259-66. PMID: 24948106.
      View in: PubMed
    10. Wang C, Zhao Q, Min J, Muniyan S, Vargas M, Wang X, Dong Y, Guy RK, Lin MF, Keiser J, Vennerstrom JL. Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978. Am J Trop Med Hyg. 2014 Jun; 90(6):1156-8. PMID: 24686741.
      View in: PubMed
    11. Hooft van Huijsduijnen R, Guy RK, Chibale K, Haynes RK, Peitz I, Kelter G, Phillips MA, Vennerstrom JL, Yuthavong Y, Wells TN. Anticancer properties of distinct antimalarial drug classes. PLoS One. 2013; 8(12):e82962. PMID: 24391728.
      View in: PubMed
    12. Dong Y, Wang X, Cal M, Kaiser M, Vennerstrom JL. Activity of diimidazoline amides against African trypanosomiasis. Bioorg Med Chem Lett. 2014 Feb 01; 24(3):944-8. PMID: 24398295.
      View in: PubMed
    13. Küster T, Kriegel N, Stadelmann B, Wang X, Dong Y, Vennerstrom JL, Keiser J, Hemphill A. Amino ozonides exhibit in vitro activity against Echinococcus multilocularis metacestodes. Int J Antimicrob Agents. 2014 Jan; 43(1):40-6. PMID: 24239405.
      View in: PubMed
    14. Gufford BT, Ezell EL, Robinson DH, Miller DW, Miller NJ, Gu X, Vennerstrom JL. pH-dependent stability of creatine ethyl ester: relevance to oral absorption. J Diet Suppl. 2013 Sep; 10(3):241-51. PMID: 23957855.
      View in: PubMed
    15. Wang X, Dong Y, Wittlin S, Charman SA, Chiu FC, Chollet J, Katneni K, Mannila J, Morizzi J, Ryan E, Scheurer C, Steuten J, Santo Tomas J, Snyder C, Vennerstrom JL. Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres. J Med Chem. 2013 Mar 28; 56(6):2547-55. PMID: 23489135.
      View in: PubMed
    16. Moehrle JJ, Duparc S, Siethoff C, van Giersbergen PL, Craft JC, Arbe-Barnes S, Charman SA, Gutierrez M, Wittlin S, Vennerstrom JL. First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials. Br J Clin Pharmacol. 2013 Feb; 75(2):524-37. PMID: 22759078.
      View in: PubMed
    17. Sabbah DA, Vennerstrom JL, Zhong HA. Binding selectivity studies of phosphoinositide 3-kinases using free energy calculations. J Chem Inf Model. 2012 Dec 21; 52(12):3213-24. PMID: 23157418.
      View in: PubMed
    18. Sabbah DA, Simms NA, Wang W, Dong Y, Ezell EL, Brattain MG, Vennerstrom JL, Zhong HA. N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Ka). Bioorg Med Chem. 2012 Dec 15; 20(24):7175-83. PMID: 23121722.
      View in: PubMed
    19. Fairhurst RM, Nayyar GML, Breman JG, Hallett R, Vennerstrom JL, Duong S, Ringwald P, Wellems TE, Plowe CV, Dondorp AM. Artemisinin-resistant malaria: research challenges, opportunities, and public health implications. Am J Trop Med Hyg. 2012 Aug; 87(2):231-241. PMID: 22855752.
      View in: PubMed
    20. Sabbah DA, Simms NA, Brattain MG, Vennerstrom JL, Zhong H. Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases. Bioorg Med Chem Lett. 2012 Jan 15; 22(2):876-80. PMID: 22212721.
      View in: PubMed
    21. Keiser J, Ingram K, Vargas M, Chollet J, Wang X, Dong Y, Vennerstrom JL. In vivo activity of aryl ozonides against Schistosoma species. Antimicrob Agents Chemother. 2012 Feb; 56(2):1090-2. PMID: 22106214.
      View in: PubMed
    22. Wang X, Zhao Q, Vargas M, Dong Y, Sriraghavan K, Keiser J, Vennerstrom JL. The activity of dispiro peroxides against Fasciola hepatica. Bioorg Med Chem Lett. 2011 Sep 15; 21(18):5320-3. PMID: 21802291.
      View in: PubMed
    23. Kirchhofer C, Vargas M, Braissant O, Dong Y, Wang X, Vennerstrom JL, Keiser J. Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni. Acta Trop. 2011 Apr; 118(1):56-62. PMID: 21316331.
      View in: PubMed
    24. Charman SA, Arbe-Barnes S, Bathurst IC, Brun R, Campbell M, Charman WN, Chiu FC, Chollet J, Craft JC, Creek DJ, Dong Y, Matile H, Maurer M, Morizzi J, Nguyen T, Papastogiannidis P, Scheurer C, Shackleford DM, Sriraghavan K, Stingelin L, Tang Y, Urwyler H, Wang X, White KL, Wittlin S, Zhou L, Vennerstrom JL. Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4400-5. PMID: 21300861.
      View in: PubMed
    25. Flaherty DP, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL. Phenolic bis-styrylbenzenes as ß-amyloid binding ligands and free radical scavengers. J Med Chem. 2010 Nov 25; 53(22):7992-9. PMID: 21038854.
      View in: PubMed
    26. Sabbah DA, Vennerstrom JL, Zhong H. Docking studies on isoform-specific inhibition of phosphoinositide-3-kinases. J Chem Inf Model. 2010 Oct 25; 50(10):1887-98. PMID: 20866085.
      View in: PubMed
    27. Dong Y, McCullough KJ, Wittlin S, Chollet J, Vennerstrom JL. The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone. Bioorg Med Chem Lett. 2010 Nov 15; 20(22):6359-61. PMID: 20943385.
      View in: PubMed
    28. Gufford BT, Sriraghavan K, Miller NJ, Miller DW, Gu X, Vennerstrom JL, Robinson DH. Physicochemical characterization of creatine N-methylguanidinium salts. J Diet Suppl. 2010 Sep; 7(3):240-52. PMID: 22432515.
      View in: PubMed
    29. Longo M, Zanoncelli S, Brughera M, Colombo P, Wittlin S, Vennerstrom JL, Moehrle J, Craft JC. Comparative embryotoxicity of different antimalarial peroxides: in vitro study using the rat whole embryo culture model (WEC). Reprod Toxicol. 2010 Dec; 30(4):583-90. PMID: 20708075.
      View in: PubMed
    30. Keiser J, Kirchhofer C, Haschke M, Huwyler J, Dong Y, Vennerstrom JL, Vanhoff K, Kaminsky R, Malikides N. Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep. Vet Parasitol. 2010 Oct 29; 173(3-4):228-35. PMID: 20674178.
      View in: PubMed
    31. Keiser J, Vargas M, Vennerstrom JL. Activity of antiandrogens against juvenile and adult Schistosoma mansoni in mice. J Antimicrob Chemother. 2010 Sep; 65(9):1991-5. PMID: 20576641.
      View in: PubMed
    32. Zhao Q, Vargas M, Dong Y, Zhou L, Wang X, Sriraghavan K, Keiser J, Vennerstrom JL. Structure-activity relationship of an ozonide carboxylic acid (OZ78) against Fasciola hepatica. J Med Chem. 2010 May 27; 53(10):4223-33. PMID: 20423101.
      View in: PubMed
    33. Dong Y, Chollet J, Vargas M, Mansour NR, Bickle Q, Alnouti Y, Huang J, Keiser J, Vennerstrom JL. Praziquantel analogs with activity against juvenile Schistosoma mansoni. Bioorg Med Chem Lett. 2010 Apr 15; 20(8):2481-4. PMID: 20303754.
      View in: PubMed
    34. Dong Y, Wittlin S, Sriraghavan K, Chollet J, Charman SA, Charman WN, Scheurer C, Urwyler H, Santo Tomas J, Snyder C, Creek DJ, Morizzi J, Koltun M, Matile H, Wang X, Padmanilayam M, Tang Y, Dorn A, Brun R, Vennerstrom JL. The structure-activity relationship of the antimalarial ozonide arterolane (OZ277). J Med Chem. 2010 Jan 14; 53(1):481-91. PMID: 19924861.
      View in: PubMed
    35. Fügi MA, Wittlin S, Dong Y, Vennerstrom JL. Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals. Antimicrob Agents Chemother. 2010 Mar; 54(3):1042-6. PMID: 20028825.
      View in: PubMed
    36. Tang Y, Wittlin S, Charman SA, Chollet J, Chiu FC, Morizzi J, Johnson LM, Tomas JS, Scheurer C, Snyder C, Zhou L, Dong Y, Charman WN, Matile H, Urwyler H, Dorn A, Vennerstrom JL. The comparative antimalarial properties of weak base and neutral synthetic ozonides. Bioorg Med Chem Lett. 2010 Jan 15; 20(2):563-6. PMID: 19962893.
      View in: PubMed
    37. Wang X, Creek DJ, Schiaffo CE, Dong Y, Chollet J, Scheurer C, Wittlin S, Charman SA, Dussault PH, Wood JK, Vennerstrom JL. Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity. Bioorg Med Chem Lett. 2009 Aug 15; 19(16):4542-5. PMID: 19616946.
      View in: PubMed
    38. Creek DJ, Ryan E, Charman WN, Chiu FC, Prankerd RJ, Vennerstrom JL, Charman SA. Stability of peroxide antimalarials in the presence of human hemoglobin. Antimicrob Agents Chemother. 2009 Aug; 53(8):3496-500. PMID: 19487440.
      View in: PubMed
    39. Hermone AR, Burnett JC, Nuss JE, Tressler LE, Nguyen TL, Solaja BA, Vennerstrom JL, Schmidt JJ, Wipf P, Bavari S, Gussio R. Three-dimensional database mining identifies a unique chemotype that unites structurally diverse botulinum neurotoxin serotype A inhibitors in a three-zone pharmacophore. ChemMedChem. 2008 Dec; 3(12):1905-12. PMID: 19006141.
      View in: PubMed
    40. Creek DJ, Charman WN, Chiu FC, Prankerd RJ, Dong Y, Vennerstrom JL, Charman SA. Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials. Antimicrob Agents Chemother. 2008 Apr; 52(4):1291-6. PMID: 18268087.
      View in: PubMed
    41. Zhou L, Alker A, Ruf A, Wang X, Chiu FC, Morizzi J, Charman SA, Charman WN, Scheurer C, Wittlin S, Dong Y, Hunziker D, Vennerstrom JL. Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277. Bioorg Med Chem Lett. 2008 Mar 01; 18(5):1555-8. PMID: 18262417.
      View in: PubMed
    42. Creek DJ, Charman WN, Chiu FC, Prankerd RJ, McCullough KJ, Dong Y, Vennerstrom JL, Charman SA. Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials. J Pharm Sci. 2007 Nov; 96(11):2945-56. PMID: 17549767.
      View in: PubMed
    43. Wang X, Dong Y, Wittlin S, Creek D, Chollet J, Charman SA, Tomas JS, Scheurer C, Snyder C, Vennerstrom JL. Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides. J Med Chem. 2007 Nov 15; 50(23):5840-7. PMID: 17949067.
      View in: PubMed
    44. Keiser J, Utzinger J, Vennerstrom JL, Dong Y, Brennan G, Fairweather I. Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica. Trans R Soc Trop Med Hyg. 2007 Dec; 101(12):1219-22. PMID: 17905370.
      View in: PubMed
    45. Keiser J, Xiao SH, Dong Y, Utzinger J, Vennerstrom JL. Clonorchicidal properties of the synthetic trioxolane OZ78. J Parasitol. 2007 Oct; 93(5):1208-13. PMID: 18163359.
      View in: PubMed
    46. Flaherty DP, Walsh SM, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL. Polyfluorinated bis-styrylbenzene beta-amyloid plaque binding ligands. J Med Chem. 2007 Oct 04; 50(20):4986-92. PMID: 17845017.
      View in: PubMed
    47. Kaiser M, Wittlin S, Nehrbass-Stuedli A, Dong Y, Wang X, Hemphill A, Matile H, Brun R, Vennerstrom JL. Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160). Antimicrob Agents Chemother. 2007 Aug; 51(8):2991-3. PMID: 17562801.
      View in: PubMed
    48. Dong Y, Creek D, Chollet J, Matile H, Charman SA, Wittlin S, Wood JK, Vennerstrom JL. Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers). Antimicrob Agents Chemother. 2007 Aug; 51(8):3033-5. PMID: 17485500.
      View in: PubMed
    49. Burnett JC, Opsenica D, Sriraghavan K, Panchal RG, Ruthel G, Hermone AR, Nguyen TL, Kenny TA, Lane DJ, McGrath CF, Schmidt JJ, Vennerstrom JL, Gussio R, Solaja BA, Bavari S. A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease. J Med Chem. 2007 May 03; 50(9):2127-36. PMID: 17417831.
      View in: PubMed
    50. Xiao SH, Keiser J, Chollet J, Utzinger J, Dong Y, Endriss Y, Vennerstrom JL, Tanner M. In vitro and in vivo activities of synthetic trioxolanes against major human schistosome species. Antimicrob Agents Chemother. 2007 Apr; 51(4):1440-5. PMID: 17283188.
      View in: PubMed
    51. Tang Y, Dong Y, Wittlin S, Charman SA, Chollet J, Chiu FC, Charman WN, Matile H, Urwyler H, Dorn A, Bajpai S, Wang X, Padmanilayam M, Karle JM, Brun R, Vennerstrom JL. Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides. Bioorg Med Chem Lett. 2007 Mar 01; 17(5):1260-5. PMID: 17189686.
      View in: PubMed
    52. Keiser J, Utzinger J, Tanner M, Dong Y, Vennerstrom JL. The synthetic peroxide OZ78 is effective against Echinostoma caproni and Fasciola hepatica. J Antimicrob Chemother. 2006 Dec; 58(6):1193-7. PMID: 17028093.
      View in: PubMed
    53. Padmanilayam M, Scorneaux B, Dong Y, Chollet J, Matile H, Charman SA, Creek DJ, Charman WN, Tomas JS, Scheurer C, Wittlin S, Brun R, Vennerstrom JL. Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine. Bioorg Med Chem Lett. 2006 Nov 01; 16(21):5542-5. PMID: 16931006.
      View in: PubMed
    54. Dong Y, Tang Y, Chollet J, Matile H, Wittlin S, Charman SA, Charman WN, Tomas JS, Scheurer C, Snyder C, Scorneaux B, Bajpai S, Alexander SA, Wang X, Padmanilayam M, Cheruku SR, Brun R, Vennerstrom JL. Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes. Bioorg Med Chem. 2006 Sep 15; 14(18):6368-82. PMID: 16759871.
      View in: PubMed
    55. Perry CS, Charman SA, Prankerd RJ, Chiu FC, Dong Y, Vennerstrom JL, Charman WN. Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials. J Pharm Sci. 2006 Apr; 95(4):737-47. PMID: 16435367.
      View in: PubMed
    56. Dong Y, Chollet J, Matile H, Charman SA, Chiu FC, Charman WN, Scorneaux B, Urwyler H, Santo Tomas J, Scheurer C, Snyder C, Dorn A, Wang X, Karle JM, Tang Y, Wittlin S, Brun R, Vennerstrom JL. Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes. J Med Chem. 2005 Jul 28; 48(15):4953-61. PMID: 16033274.
      View in: PubMed
    57. Tang Y, Dong Y, Wang X, Sriraghavan K, Wood JK, Vennerstrom JL. Dispiro-1,2,4-trioxane analogues of a prototype dispiro-1,2,4-trioxolane: mechanistic comparators for artemisinin in the context of reaction pathways with iron(II). J Org Chem. 2005 Jun 24; 70(13):5103-10. PMID: 15960511.
      View in: PubMed
    58. Burnett JC, Schmidt JJ, McGrath CF, Nguyen TL, Hermone AR, Panchal RG, Vennerstrom JL, Kodukula K, Zaharevitz DW, Gussio R, Bavari S. Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding. Bioorg Med Chem. 2005 Jan 17; 13(2):333-41. PMID: 15598556.
      View in: PubMed
    59. Tang Y, Dong Y, Karle JM, DiTusa CA, Vennerstrom JL. Synthesis of tetrasubstituted ozonides by the Griesbaum coozonolysis reaction: diastereoselectivity and functional group transformations by post-ozonolysis reactions. J Org Chem. 2004 Sep 17; 69(19):6470-3. PMID: 15357611.
      View in: PubMed
    60. Vennerstrom JL, Arbe-Barnes S, Brun R, Charman SA, Chiu FC, Chollet J, Dong Y, Dorn A, Hunziker D, Matile H, McIntosh K, Padmanilayam M, Santo Tomas J, Scheurer C, Scorneaux B, Tang Y, Urwyler H, Wittlin S, Charman WN. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature. 2004 Aug 19; 430(7002):900-4. PMID: 15318224.
      View in: PubMed
    61. Tang Y, Dong Y, Vennerstrom JL. Synthetic peroxides as antimalarials. Med Res Rev. 2004 Jul; 24(4):425-48. PMID: 15170591.
      View in: PubMed
    62. Sunkara G, Ayalasomayajula SP, Rao CS, Vennerstrom JL, DeRuiter J, Kompella UB. Systemic and ocular pharmacokinetics of N-4-benzoylaminophenylsulfonylglycine (BAPSG), a novel aldose reductase inhibitor. J Pharm Pharmacol. 2004 Mar; 56(3):351-8. PMID: 15025860.
      View in: PubMed
    63. Becker K, Tilley L, Vennerstrom JL, Roberts D, Rogerson S, Ginsburg H. Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions. Int J Parasitol. 2004 Feb; 34(2):163-89. PMID: 15037104.
      View in: PubMed
    64. Burnett JC, Schmidt JJ, Stafford RG, Panchal RG, Nguyen TL, Hermone AR, Vennerstrom JL, McGrath CF, Lane DJ, Sausville EA, Zaharevitz DW, Gussio R, Bavari S. Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity. Biochem Biophys Res Commun. 2003 Oct 10; 310(1):84-93. PMID: 14511652.
      View in: PubMed
    65. Cheruku SR, Maiti S, Dorn A, Scorneaux B, Bhattacharjee AK, Ellis WY, Vennerstrom JL. Carbon isosteres of the 4-aminopyridine substructure of chloroquine: effects on pK(a), hematin binding, inhibition of hemozoin formation, and parasite growth. J Med Chem. 2003 Jul 03; 46(14):3166-9. PMID: 12825955.
      View in: PubMed
    66. Sanderson SD, Cheruku SR, Padmanilayam MP, Vennerstrom JL, Thiele GM, Palmatier MI, Bevins RA. Immunization to nicotine with a peptide-based vaccine composed of a conformationally biased agonist of C5a as a molecular adjuvant. Int Immunopharmacol. 2003 Jan; 3(1):137-46. PMID: 12538044.
      View in: PubMed
    67. Dong Y, Vennerstrom JL. Mechanisms of in situ activation for peroxidic antimalarials. Redox Rep. 2003; 8(5):284-8. PMID: 14962366.
      View in: PubMed
    68. Bhattacharjee AK, Kyle DE, Vennerstrom JL, Milhous WK. A 3D QSAR pharmacophore model and quantum chemical structure--activity analysis of chloroquine(CQ)-resistance reversal. J Chem Inf Comput Sci. 2002 Sep-Oct; 42(5):1212-20. PMID: 12377011.
      View in: PubMed
    69. Ihnat PM, Vennerstrom JL, Robinson DH. Solution equilibria of deferoxamine amides. J Pharm Sci. 2002 Jul; 91(7):1733-41. PMID: 12115836.
      View in: PubMed
    70. Bhattacharjee AK, Kyle DE, Vennerstrom JL. Structural analysis of chloroquine resistance reversal by imipramine analogs. Antimicrob Agents Chemother. 2001 Sep; 45(9):2655-7. PMID: 11502547.
      View in: PubMed
    71. Dorn A, Scovill JP, Ellis WY, Matile H, Ridley RG, Vennerstrom JL. Short report: floxacrine analog WR 243251 inhibits hematin polymerization. Am J Trop Med Hyg. 2001 Jul; 65(1):19-20. PMID: 11504401.
      View in: PubMed
    72. Ihnat PM, Vennerstrom JL, Robinson DH. Synthesis and solution properties of deferoxamine amides. J Pharm Sci. 2000 Dec; 89(12):1525-36. PMID: 11042600.
      View in: PubMed
    73. Vennerstrom JL, Dong Y, Andersen SL, Ager AL, Fu H, Miller RE, Wesche DL, Kyle DE, Gerena L, Walters SM, Wood JK, Edwards G, Holme AD, McLean WG, Milhous WK. Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes. J Med Chem. 2000 Jul 13; 43(14):2753-8. PMID: 10893313.
      View in: PubMed
    74. Vippagunta SR, Dorn A, Ridley RG, Vennerstrom JL. Characterization of chloroquine-hematin mu-oxo dimer binding by isothermal titration calorimetry. Biochim Biophys Acta. 2000 Jul 03; 1475(2):133-40. PMID: 10832027.
      View in: PubMed
    75. Vennerstrom JL, Ager AL, Andersen SL, Grace JM, Wongpanich V, Angerhofer CK, Hu JK, Wesche DL. Assessment of the antimalarial potential of tetraoxane WR 148999. Am J Trop Med Hyg. 2000 May; 62(5):573-8. PMID: 11289666.
      View in: PubMed
    76. McCullough KJ, Wood JK, Bhattacharjee AK, Dong Y, Kyle DE, Milhous WK, Vennerstrom JL. Methyl-substituted dispiro-1,2,4,5-tetraoxanes: correlations of structural studies with antimalarial activity. J Med Chem. 2000 Mar 23; 43(6):1246-9. PMID: 10737758.
      View in: PubMed
    77. Vippagunta SR, Dorn A, Matile H, Bhattacharjee AK, Karle JM, Ellis WY, Ridley RG, Vennerstrom JL. Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth. J Med Chem. 1999 Nov 04; 42(22):4630-9. PMID: 10579825.
      View in: PubMed
    78. Vippagunta SR, Dorn A, Bubendorf A, Ridley RG, Vennerstrom JL. Deferoxamine: stimulation of hematin polymerization and antagonism of its inhibition by chloroquine. Biochem Pharmacol. 1999 Sep 01; 58(5):817-24. PMID: 10449192.
      View in: PubMed
    79. Dong Y, Matile H, Chollet J, Kaminsky R, Wood JK, Vennerstrom JL. Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups. J Med Chem. 1999 Apr 22; 42(8):1477-80. PMID: 10212135.
      View in: PubMed
    80. Vennerstrom JL, Nuzum EO, Miller RE, Dorn A, Gerena L, Dande PA, Ellis WY, Ridley RG, Milhous WK. 8-Aminoquinolines active against blood stage Plasmodium falciparum in vitro inhibit hematin polymerization. Antimicrob Agents Chemother. 1999 Mar; 43(3):598-602. PMID: 10049273.
      View in: PubMed
    81. Chen SC, Wang X, Xu G, Zhou L, Vennerstrom JL, Gonzalez F, Gelboin HV, Mirvish SS. Depentylation of [3H-pentyl]methyl-n-amylnitrosamine by rat esophageal and liver microsomes and by rat and human cytochrome P450 isoforms. Cancer Res. 1999 Jan 01; 59(1):91-8. PMID: 9892192.
      View in: PubMed
    82. Vennerstrom JL, Ager AL, Dorn A, Andersen SL, Gerena L, Ridley RG, Milhous WK. Bisquinolines. 2. Antimalarial N,N-bis(7-chloroquinolin-4-yl)heteroalkanediamines. J Med Chem. 1998 Oct 22; 41(22):4360-4. PMID: 9784111.
      View in: PubMed
    83. Dorn A, Vippagunta SR, Matile H, Jaquet C, Vennerstrom JL, Ridley RG. An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials. Biochem Pharmacol. 1998 Mar 15; 55(6):727-36. PMID: 9586944.
      View in: PubMed
    84. Dorn A, Vippagunta SR, Matile H, Bubendorf A, Vennerstrom JL, Ridley RG. A comparison and analysis of several ways to promote haematin (haem) polymerisation and an assessment of its initiation in vitro. Biochem Pharmacol. 1998 Mar 15; 55(6):737-47. PMID: 9586945.
      View in: PubMed
    85. Ridley RG, Dorn A, Vippagunta SR, Vennerstrom JL. Haematin (haem) polymerization and its inhibition by quinoline antimalarials. Ann Trop Med Parasitol. 1997 Jul; 91(5):559-66. PMID: 9329993.
      View in: PubMed
    86. Vennerstrom JL, Makler MT, Angerhofer CK, Williams JA. Antimalarial dyes revisited: xanthenes, azines, oxazines, and thiazines. Antimicrob Agents Chemother. 1995 Dec; 39(12):2671-7. PMID: 8593000.
      View in: PubMed
    87. Basco LK, Andersen SL, Milhous WK, Le Bras J, Vennerstrom JL. In vitro activity of bisquinoline WR268,668 against African clones and isolates of Plasmodium falciparum. Am J Trop Med Hyg. 1994 Feb; 50(2):200-5. PMID: 8116813.
      View in: PubMed
    88. Casale GP, Vennerstrom JL, Bavari S, Wang TL. Inhibition of interleukin 2 driven proliferation of mouse CTLL2 cells, by selected carbamate and organophosphate insecticides and congeners of carbaryl. Immunopharmacol Immunotoxicol. 1993 Mar-Jun; 15(2-3):199-215. PMID: 8349949.
      View in: PubMed
    89. Vennerstrom JL, Fu HN, Ellis WY, Ager AL, Wood JK, Andersen SL, Gerena L, Milhous WK. Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides. J Med Chem. 1992 Aug 07; 35(16):3023-7. PMID: 1501229.
      View in: PubMed
    90. Vennerstrom JL, Ellis WY, Ager AL, Andersen SL, Gerena L, Milhous WK. Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria. J Med Chem. 1992 May 29; 35(11):2129-34. PMID: 1597862.
      View in: PubMed
    91. Vennerstrom JL, Lovelace JK, Waits VB, Hanson WL, Klayman DL. Berberine derivatives as antileishmanial drugs. Antimicrob Agents Chemother. 1990 May; 34(5):918-21. PMID: 2360830.
      View in: PubMed
    92. Vennerstrom JL, Acton N, Lin AJ, Klayman DL. Peroxides as oxidant antimalarials. Drug Des Deliv. 1989 Jan; 4(1):45-54. PMID: 2673281.
      View in: PubMed
    93. Vennerstrom JL. Amine peroxides as potential antimalarials. J Med Chem. 1989 Jan; 32(1):64-7. PMID: 2642554.
      View in: PubMed
    94. Vennerstrom JL, Eaton JW. Oxidants, oxidant drugs, and malaria. J Med Chem. 1988 Jul; 31(7):1269-77. PMID: 3290484.
      View in: PubMed
    95. Vennerstrom JL, Klayman DL. Protoberberine alkaloids as antimalarials. J Med Chem. 1988 Jun; 31(6):1084-7. PMID: 3286870.
      View in: PubMed
    96. Vennerstrom JL, Holmes TJ. Preparation and evaluation of electrophilic derivatives of phenylbutazone as inhibitors of prostaglandin-H synthase. J Med Chem. 1987 Mar; 30(3):563-7. PMID: 3102742.
      View in: PubMed
    97. Vennerstrom JL, Holmes TJ. Prostaglandin-H synthase inhibition by malonamides. Ring-opened analogues of phenylbutazone. J Med Chem. 1987 Feb; 30(2):434-7. PMID: 3100804.
      View in: PubMed
    98. Rao GH, John V, Hill TD, Vennerstrom JL, White JG, Holmes TJ. Inhibition of platelet aggregation by novel triphenylethylene analogs. Thromb Res. 1986 Nov 15; 44(4):527-38. PMID: 3099420.
      View in: PubMed
    99. Holmes TJ, Vennerstrom JL, John V. Inhibition of cyclooxygenase mediated by electrochemical oxidation of gentisic acid. J Biol Chem. 1985 Nov 15; 260(26):14092-5. PMID: 3932349.
      View in: PubMed
    100. Holmes TJ, Vennerstrom JL, John V. Electrolysis-mediated irreversible inactivation of lipoxygenase directed toward electroaffinity labelling. Biochem Biophys Res Commun. 1984 Aug 30; 123(1):156-62. PMID: 6433914.
      View in: PubMed
    Vennerstrom's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description