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Dr Giuseppe Del Giudice

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lofano G, Kumar A, Finco O, Del Giudice G, Bertholet S. B Cells and Functional Antibody Responses to Combat Influenza. Front Immunol. 2015; 6:336. PMID: 26175732.
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    2. Chiappini N, Cantisani R, Pancotto L, Ruggiero P, Rosa D, Manetti A, Romano A, Montagnani F, Bertholet S, Castellino F, Del Giudice G. Innate Response Activator (IRA) B Cells Reside in Human Tonsils and Internalize Bacteria In Vitro. PLoS One. 2015; 10(6):e0129879. PMID: 26066485.
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    3. Del Giudice G, Rappuoli R. Inactivated and adjuvanted influenza vaccines. Curr Top Microbiol Immunol. 2015; 386:151-80. PMID: 25038938.
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    4. Zedda L, Forleo-Neto E, Vertruyen A, Raes M, Marchant A, Jansen W, Clouting H, Arora A, Beatty ME, Galli G, Del Giudice G, Castellino F. Dissecting the immune response to MF59-adjuvanted and nonadjuvanted seasonal influenza vaccines in children less than three years of age. Pediatr Infect Dis J. 2015 Jan; 34(1):73-8. PMID: 25037034.
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    5. Del Giudice G, Weinberger B, Grubeck-Loebenstein B. Vaccines for the elderly. Gerontology. 2015; 61(3):203-10. PMID: 25402229.
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    6. Rappuoli R, Pizza M, Del Giudice G, De Gregorio E. Vaccines, new opportunities for a new society. Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34):12288-93. PMID: 25136130.
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    7. Khurana S, Coyle EM, Dimitrova M, Castellino F, Nicholson K, Del Giudice G, Golding H. Heterologous prime-boost vaccination with MF59-adjuvanted H5 vaccines promotes antibody affinity maturation towards the hemagglutinin HA1 domain and broad H5N1 cross-clade neutralization. PLoS One. 2014; 9(4):e95496. PMID: 24755693.
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    8. Della Cioppa G, Nicolay U, Lindert K, Leroux-Roels G, Clement F, Castellino F, Galli C, Groth N, Levin Y, Del Giudice G. A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration. Hum Vaccin Immunother. 2014; 10(6):1701-10. PMID: 24732325.
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    9. Nair N, Buti L, Faenzi E, Buricchi F, Nuti S, Sammicheli C, Tavarini S, Popp MW, Ploegh H, Berti F, Pizza M, Castellino F, Finco O, Rappuoli R, Del Giudice G, Galli G, Bardelli M. Optimized fluorescent labeling to identify memory B cells specific for Neisseria meningitidis serogroup B vaccine antigens ex vivo. Immun Inflamm Dis. 2013 Oct; 1(1):3-13. PMID: 25400913.
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    10. Mastelic B, Garçon N, Del Giudice G, Golding H, Gruber M, Neels P, Fritzell B. Predictive markers of safety and immunogenicity of adjuvanted vaccines. Biologicals. 2013 Nov; 41(6):458-68. PMID: 24071553.
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    11. Bardelli M, Alleri L, Angiolini F, Buricchi F, Tavarini S, Sammicheli C, Nuti S, Degl'Innocenti E, Isnardi I, Fragapane E, Del Giudice G, Castellino F, Galli G. Ex vivo analysis of human memory B lymphocytes specific for A and B influenza hemagglutinin by polychromatic flow-cytometry. PLoS One. 2013; 8(8):e70620. PMID: 23976947.
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    12. Spensieri F, Borgogni E, Zedda L, Bardelli M, Buricchi F, Volpini G, Fragapane E, Tavarini S, Finco O, Rappuoli R, Del Giudice G, Galli G, Castellino F. Human circulating influenza-CD4+ ICOS1+IL-21+ T cells expand after vaccination, exert helper function, and predict antibody responses. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14330-5. PMID: 23940329.
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    13. Boraschi D, Aguado MT, Dutel C, Goronzy J, Louis J, Grubeck-Loebenstein B, Rappuoli R, Del Giudice G. The gracefully aging immune system. Sci Transl Med. 2013 May 15; 5(185):185ps8. PMID: 23677590.
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    14. Buricchi F, Bardelli M, Malzone C, Capecchi B, Nicolay U, Fragapane E, Castellino F, Del Giudice G, Galli G, Finco O. Impact of preexisting memory to seasonal A/H1N1 influenza virus on the immune response following vaccination against avian A/H5N1 virus. Eur J Immunol. 2013 Mar; 43(3):641-8. PMID: 23238926.
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    15. Pancotto L, De Angelis G, Bizzarri E, Barocchi MA, Del Giudice G, Moschioni M, Ruggiero P. Expression of the Streptococcus pneumoniae pilus-1 undergoes on and off switching during colonization in mice. Sci Rep. 2013; 3:2040. PMID: 23784148.
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    16. Del Giudice G, Fragapane E, Della Cioppa G, Rappuoli R. Aflunov®: a vaccine tailored for pre-pandemic and pandemic approaches against influenza. Expert Opin Biol Ther. 2013 Jan; 13(1):121-35. PMID: 23189937.
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    17. Faenzi E, Zedda L, Bardelli M, Spensieri F, Borgogni E, Volpini G, Buricchi F, Pasini FL, Capecchi PL, Montanaro F, Belli R, Lattanzi M, Piccirella S, Montomoli E, Ahmed SS, Rappuoli R, Del Giudice G, Finco O, Castellino F, Galli G. One dose of an MF59-adjuvanted pandemic A/H1N1 vaccine recruits pre-existing immune memory and induces the rapid rise of neutralizing antibodies. Vaccine. 2012 Jun 08; 30(27):4086-94. PMID: 22521851.
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    18. Della Cioppa G, Nicolay U, Lindert K, Leroux-Roels G, Clement F, Castellino F, Galli G, Groth N, Del Giudice G. Superior immunogenicity of seasonal influenza vaccines containing full dose of MF59 (®) adjuvant: results from a dose-finding clinical trial in older adults. Hum Vaccin Immunother. 2012 Feb; 8(2):216-27. PMID: 22426371.
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    19. Dormitzer PR, Tsai TF, Del Giudice G. New technologies for influenza vaccines. Hum Vaccin Immunother. 2012 Jan; 8(1):45-58. PMID: 22251994.
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    20. Black S, Nicolay U, Vesikari T, Knuf M, Del Giudice G, Della Cioppa G, Tsai T, Clemens R, Rappuoli R. Hemagglutination inhibition antibody titers as a correlate of protection for inactivated influenza vaccines in children. Pediatr Infect Dis J. 2011 Dec; 30(12):1081-5. PMID: 21983214.
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    21. Khurana S, Verma N, Yewdell JW, Hilbert AK, Castellino F, Lattanzi M, Del Giudice G, Rappuoli R, Golding H. MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines. Sci Transl Med. 2011 Jun 01; 3(85):85ra48. PMID: 21632986.
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    22. Romi B, Soldaini E, Pancotto L, Castellino F, Del Giudice G, Schiavetti F. Helicobacter pylori induces activation of human peripheral ?d+ T lymphocytes. PLoS One. 2011 Apr 29; 6(4):e19324. PMID: 21559446.
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    23. O'Hagan DT, Rappuoli R, De Gregorio E, Tsai T, Del Giudice G. MF59 adjuvant: the best insurance against influenza strain diversity. Expert Rev Vaccines. 2011 Apr; 10(4):447-62. PMID: 21506643.
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    24. van den Brand JM, Kreijtz JH, Bodewes R, Stittelaar KJ, van Amerongen G, Kuiken T, Simon J, Fouchier RA, Del Giudice G, Rappuoli R, Rimmelzwaan GF, Osterhaus AD. Efficacy of vaccination with different combinations of MF59-adjuvanted and nonadjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 (2009) influenza virus infection in ferrets. J Virol. 2011 Mar; 85(6):2851-8. PMID: 21209108.
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    25. Dormitzer PR, Galli G, Castellino F, Golding H, Khurana S, Del Giudice G, Rappuoli R. Influenza vaccine immunology. Immunol Rev. 2011 Jan; 239(1):167-77. PMID: 21198671.
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    26. Ansaldi F, Zancolli M, Durando P, Montomoli E, Sticchi L, Del Giudice G, Icardi G. Antibody response against heterogeneous circulating influenza virus strains elicited by MF59- and non-adjuvanted vaccines during seasons with good or partial matching between vaccine strain and clinical isolates. Vaccine. 2010 Jun 07; 28(25):4123-9. PMID: 20433807.
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    27. Boraschi D, Del Giudice G, Dutel C, Ivanoff B, Rappuoli R, Grubeck-Loebenstein B. Ageing and immunity: addressing immune senescence to ensure healthy ageing. Vaccine. 2010 May 07; 28(21):3627-31. PMID: 20362616.
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    28. Tamayo E, Postigo J, González J, Fernández-Rey M, Iglesias M, Santiuste I, Riccardi C, Rappuoli R, Del Giudice G, Merino R, Merino J. GITR contributes to the systemic adjuvanticity of the Escherichia coli heat-labile enterotoxin. Eur J Immunol. 2010 Mar; 40(3):754-63. PMID: 20017194.
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    29. Rappuoli R, Medini D, Siena E, Budroni S, Dormitzer PR, Del Giudice G. Building an insurance against modern pandemics. Curr Opin Investig Drugs. 2010 Feb; 11(2):126-30. PMID: 20112161.
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    30. Khurana S, Chearwae W, Castellino F, Manischewitz J, King LR, Honorkiewicz A, Rock MT, Edwards KM, Del Giudice G, Rappuoli R, Golding H. Vaccines with MF59 adjuvant expand the antibody repertoire to target protective sites of pandemic avian H5N1 influenza virus. Sci Transl Med. 2010 Jan 20; 2(15):15ra5. PMID: 20371470.
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    31. Del Giudice G, Stittelaar KJ, van Amerongen G, Simon J, Osterhaus AD, Stöhr K, Rappuoli R. Seasonal influenza vaccine provides priming for A/H1N1 immunization. Sci Transl Med. 2009 Dec 23; 1(12):12re1. PMID: 20371459.
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    32. Rappuoli R, Del Giudice G, Nabel GJ, Osterhaus AD, Robinson R, Salisbury D, Stöhr K, Treanor JJ. Public health. Rethinking influenza. Science. 2009 Oct 02; 326(5949):50. PMID: 19797644.
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    33. Lewis DJ, Huo Z, Barnett S, Kromann I, Giemza R, Galiza E, Woodrow M, Thierry-Carstensen B, Andersen P, Novicki D, Del Giudice G, Rappuoli R. Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin. PLoS One. 2009 Sep 16; 4(9):e6999. PMID: 19756141.
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    34. Alberini I, Del Tordello E, Fasolo A, Temperton NJ, Galli G, Gentile C, Montomoli E, Hilbert AK, Banzhoff A, Del Giudice G, Donnelly JJ, Rappuoli R, Capecchi B. Pseudoparticle neutralization is a reliable assay to measure immunity and cross-reactivity to H5N1 influenza viruses. Vaccine. 2009 Oct 09; 27(43):5998-6003. PMID: 19665606.
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    35. Castellino F, Galli G, Del Giudice G, Rappuoli R. Generating memory with vaccination. Eur J Immunol. 2009 Aug; 39(8):2100-5. PMID: 19637203.
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    36. Del Giudice G, Malfertheiner P, Rappuoli R. Development of vaccines against Helicobacter pylori. Expert Rev Vaccines. 2009 Aug; 8(8):1037-49. PMID: 19627186.
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    37. Gianfaldoni C, Maccari S, Pancotto L, Rossi G, Hilleringmann M, Pansegrau W, Sinisi A, Moschioni M, Masignani V, Rappuoli R, Del Giudice G, Ruggiero P. Sortase A confers protection against Streptococcus pneumoniae in mice. Infect Immun. 2009 Jul; 77(7):2957-61. PMID: 19433540.
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    38. Galli G, Hancock K, Hoschler K, DeVos J, Praus M, Bardelli M, Malzone C, Castellino F, Gentile C, McNally T, Del Giudice G, Banzhoff A, Brauer V, Montomoli E, Zambon M, Katz J, Nicholson K, Stephenson I. Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7962-7. PMID: 19416838.
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    39. Galli G, Medini D, Borgogni E, Zedda L, Bardelli M, Malzone C, Nuti S, Tavarini S, Sammicheli C, Hilbert AK, Brauer V, Banzhoff A, Rappuoli R, Del Giudice G, Castellino F. Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels. Proc Natl Acad Sci U S A. 2009 Mar 10; 106(10):3877-82. PMID: 19237568.
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    40. Tamayo E, Postigo J, Del Giudice G, Rappuoli R, Benito A, Yagita H, Merino R, Merino J. Involvement of the intrinsic and extrinsic cell-death pathways in the induction of apoptosis of mature lymphocytes by the Escherichia coli heat-labile enterotoxin. Eur J Immunol. 2009 Feb; 39(2):439-46. PMID: 19180465.
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    41. Banzhoff A, Pellegrini M, Del Giudice G, Fragapane E, Groth N, Podda A. MF59-adjuvanted vaccines for seasonal and pandemic influenza prophylaxis. Influenza Other Respir Viruses. 2008 Nov; 2(6):243-9. PMID: 19453401.
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    42. Malfertheiner P, Schultze V, Rosenkranz B, Kaufmann SH, Ulrichs T, Novicki D, Norelli F, Contorni M, Peppoloni S, Berti D, Tornese D, Ganju J, Palla E, Rappuoli R, Scharschmidt BF, Del Giudice G. Safety and immunogenicity of an intramuscular Helicobacter pylori vaccine in noninfected volunteers: a phase I study. Gastroenterology. 2008 Sep; 135(3):787-95. PMID: 18619971.
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    43. Stickings P, Peyre M, Coombes L, Muller S, Rappuoli R, Del Giudice G, Partidos CD, Sesardic D. Transcutaneous immunization with cross-reacting material CRM(197) of diphtheria toxin boosts functional antibody levels in mice primed parenterally with adsorbed diphtheria toxoid vaccine. Infect Immun. 2008 Apr; 76(4):1766-73. PMID: 18227167.
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    44. Wack A, Baudner BC, Hilbert AK, Manini I, Nuti S, Tavarini S, Scheffczik H, Ugozzoli M, Singh M, Kazzaz J, Montomoli E, Del Giudice G, Rappuoli R, O'Hagan DT. Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice. Vaccine. 2008 Jan 24; 26(4):552-61. PMID: 18162266.
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    45. Vajdy M, Baudner B, Del Giudice G, O'Hagan D. A vaccination strategy to enhance mucosal and systemic antibody and T cell responses against influenza. Clin Immunol. 2007 May; 123(2):166-75. PMID: 17349825.
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    46. Ruggiero P, Rossi G, Tombola F, Pancotto L, Lauretti L, Del Giudice G, Zoratti M. Red wine and green tea reduce H pylori- or VacA-induced gastritis in a mouse model. World J Gastroenterol. 2007 Jan 21; 13(3):349-54. PMID: 17230601.
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    47. Del Giudice G, Fragapane E, Bugarini R, Hora M, Henriksson T, Palla E, O'hagan D, Donnelly J, Rappuoli R, Podda A. Vaccines with the MF59 adjuvant do not stimulate antibody responses against squalene. Clin Vaccine Immunol. 2006 Sep; 13(9):1010-3. PMID: 16960112.
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    48. González CA, Jakszyn P, Pera G, Agudo A, Bingham S, Palli D, Ferrari P, Boeing H, del Giudice G, Plebani M, Carneiro F, Nesi G, Berrino F, Sacerdote C, Tumino R, Panico S, Berglund G, Simán H, Nyrén O, Hallmans G, Martinez C, Dorronsoro M, Barricarte A, Navarro C, Quirós JR, Allen N, Key TJ, Day NE, Linseisen J, Nagel G, Bergmann MM, Overvad K, Jensen MK, Tjonneland A, Olsen A, Bueno-de-Mesquita HB, Ocke M, Peeters PH, Numans ME, Clavel-Chapelon F, Boutron-Ruault MC, Trichopoulou A, Psaltopoulou T, Roukos D, Lund E, Hemon B, Kaaks R, Norat T, Riboli E. Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst. 2006 Mar 01; 98(5):345-54. PMID: 16507831.
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    49. Del Giudice G, Hilbert AK, Bugarini R, Minutello A, Popova O, Toneatto D, Schoendorf I, Borkowski A, Rappuoli R, Podda A. An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine. Vaccine. 2006 Apr 12; 24(16):3063-5. PMID: 16464520.
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    50. Tamayo E, Merino R, González-Rojas J, Marquina R, Santiuste I, Amado JA, Rappuoli R, Del Giudice G, Merino J. The Escherichia coli heat-labile enterotoxin induces apoptosis of immature lymphocytes in vivo via a glucocorticoid-dependent pathway. Eur J Immunol. 2005 Dec; 35(12):3505-15. PMID: 16285009.
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    51. Daems R, Del Giudice G, Rappuoli R. Anticipating crisis: towards a pandemic flu vaccination strategy through alignment of public health and industrial policy. Vaccine. 2005 Dec 30; 23(50):5732-42. PMID: 16271423.
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    52. Baudner BC, Verhoef JC, Giuliani MM, Peppoloni S, Rappuoli R, Del Giudice G, Junginger HE. Protective immune responses to meningococcal C conjugate vaccine after intranasal immunization of mice with the LTK63 mutant plus chitosan or trimethyl chitosan chloride as novel delivery platform. J Drug Target. 2005 Sep-Nov; 13(8-9):489-98. PMID: 16332574.
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    53. Baraldo K, Mori E, Bartoloni A, Norelli F, Grandi G, Rappuoli R, Finco O, Del Giudice G. Combined conjugate vaccines: enhanced immunogenicity with the N19 polyepitope as a carrier protein. Infect Immun. 2005 Sep; 73(9):5835-41. PMID: 16113302.
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    54. Mawas F, Peyre M, Beignon AS, Frost L, Del Giudice G, Rappuoli R, Muller S, Sesardic D, Partidos CD. Successful induction of protective antibody responses against Haemophilus influenzae type b and diphtheria after transcutaneous immunization with the glycoconjugate polyribosyl ribitol phosphate-cross-reacting material 197 vaccine. J Infect Dis. 2004 Sep 15; 190(6):1177-82. PMID: 15319869.
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    55. Baraldo K, Mori E, Bartoloni A, Petracca R, Giannozzi A, Norelli F, Rappuoli R, Grandi G, Del Giudice G. N19 polyepitope as a carrier for enhanced immunogenicity and protective efficacy of meningococcal conjugate vaccines. Infect Immun. 2004 Aug; 72(8):4884-7. PMID: 15271954.
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    56. Rossi G, Ruggiero P, Peppoloni S, Pancotto L, Fortuna D, Lauretti L, Volpini G, Mancianti S, Corazza M, Taccini E, Di Pisa F, Rappuoli R, Del Giudice G. Therapeutic vaccination against Helicobacter pylori in the beagle dog experimental model: safety, immunogenicity, and efficacy. Infect Immun. 2004 Jun; 72(6):3252-9. PMID: 15155627.
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    57. Rossi G, Romagnoli S, Lauretti L, Pancotto L, Taccini E, Rappuoli R, Del Giudice G, Ruggiero P. Helicobacter pylori infection negatively influences pregnancy outcome in a mouse model. Helicobacter. 2004 Apr; 9(2):152-7. PMID: 15068417.
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    58. de Bernard M, Cappon A, Del Giudice G, Rappuoli R, Montecucco C. The multiple cellular activities of the VacA cytotoxin of Helicobacter pylori. Int J Med Microbiol. 2004 Apr; 293(7-8):589-97. PMID: 15149036.
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    59. Baudner BC, Morandi M, Giuliani MM, Verhoef JC, Junginger HE, Costantino P, Rappuoli R, Del Giudice G. Modulation of immune response to group C meningococcal conjugate vaccine given intranasally to mice together with the LTK63 mucosal adjuvant and the trimethyl chitosan delivery system. J Infect Dis. 2004 Mar 01; 189(5):828-32. PMID: 14976599.
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    60. Del Giudice G, Michetti P. Inflammation, immunity and vaccines for Helicobacter pylori. Helicobacter. 2004; 9 Suppl 1:23-8. PMID: 15347302.
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    61. Dubreuil JD, Ruggiero P, Rappuoli R, Del Giudice G. Effect of heparin binding on Helicobacter pylori resistance to serum. J Med Microbiol. 2004 Jan; 53(Pt 1):9-12. PMID: 14663099.
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    62. Ruggiero P, Peppoloni S, Rappuoli R, Del Giudice G. The quest for a vaccine against Helicobacter pylori: how to move from mouse to man? Microbes Infect. 2003 Jul; 5(8):749-56. PMID: 12814776.
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    63. Del Giudice G. Vaccination strategies. An overview. Vaccine. 2003 Jun 01; 21 Suppl 2:S83-8. PMID: 12763688.
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    64. Nishioka H, Baesso I, Semenzato G, Trentin L, Rappuoli R, Del Giudice G, Montecucco C. The neutrophil-activating protein of Helicobacter pylori (HP-NAP) activates the MAPK pathway in human neutrophils. Eur J Immunol. 2003 Apr; 33(4):840-9. PMID: 12672049.
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    65. Podda A, Del Giudice G. MF59-adjuvanted vaccines: increased immunogenicity with an optimal safety profile. Expert Rev Vaccines. 2003 Apr; 2(2):197-203. PMID: 12899571.
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    66. Peppoloni S, Ruggiero P, Contorni M, Morandi M, Pizza M, Rappuoli R, Podda A, Del Giudice G. Mutants of the Escherichia coli heat-labile enterotoxin as safe and strong adjuvants for intranasal delivery of vaccines. Expert Rev Vaccines. 2003 Apr; 2(2):285-93. PMID: 12899578.
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    67. Seydel A, Tasca E, Berti D, Rappuoli R, Del Giudice G, Montecucco C. Characterization and immunogenicity of the CagF protein of the cag pathogenicity island of Helicobacter pylori. Infect Immun. 2002 Nov; 70(11):6468-70. PMID: 12379730.
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    68. Peppoloni S, Mancianti S, Volpini G, Nuti S, Ruggiero P, Rappuoli R, Blasi E, Del Giudice G. Antibody-dependent macrophage-mediated activity against Helicobacter pylori in the absence of complement. Eur J Immunol. 2002 Oct; 32(10):2721-5. PMID: 12355423.
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    69. Montemurro P, Nishioka H, Dundon WG, de Bernard M, Del Giudice G, Rappuoli R, Montecucco C. The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a potent stimulant of mast cells. Eur J Immunol. 2002 03; 32(3):671-6. PMID: 11857341.
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    70. Lattanzi M, Del Giudice G. Meningitis C vaccine (North American vaccine). Curr Opin Investig Drugs. 2002 Jan; 3(1):51-3. PMID: 12054072.
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    71. Del Giudice G. Towards the development of vaccines against Helicobacter pylori: status and issues. Curr Opin Investig Drugs. 2001 Jan; 2(1):40-4. PMID: 11527009.
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