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Professor Douglas Young

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Via LE, Weiner DM, Schimel D, Lin PL, Dayao E, Tankersley SL, Cai Y, Coleman MT, Tomko J, Paripati P, Orandle M, Kastenmayer RJ, Tartakovsky M, Rosenthal A, Portevin D, Eum SY, Lahouar S, Gagneux S, Young DB, Flynn JL, Barry CE. Differential virulence and disease progression following Mycobacterium tuberculosis complex infection of the common marmoset (Callithrix jacchus). Infect Immun. 2013 Aug; 81(8):2909-19. PMID: 23716617; PMCID: PMC3719573.
    2. Firdessa R, Berg S, Hailu E, Schelling E, Gumi B, Erenso G, Gadisa E, Kiros T, Habtamu M, Hussein J, Zinsstag J, Robertson BD, Ameni G, Lohan AJ, Loftus B, Comas I, Gagneux S, Tschopp R, Yamuah L, Hewinson G, Gordon SV, Young DB, Aseffa A. Mycobacterial lineages causing pulmonary and extrapulmonary tuberculosis, Ethiopia. Emerg Infect Dis. 2013 Mar; 19(3):460-3. PMID: 23622814; PMCID: PMC3647644.
    3. Gideon HP, Wilkinson KA, Rustad TR, Oni T, Guio H, Sherman DR, Vordermeier HM, Robertson BD, Young DB, Wilkinson RJ. Bioinformatic and empirical analysis of novel hypoxia-inducible targets of the human antituberculosis T cell response. J Immunol. 2012 Dec 15; 189(12):5867-76. PMID: 23169589; PMCID: PMC3519923.
    4. Vordermeier M, Ameni G, Berg S, Bishop R, Robertson BD, Aseffa A, Hewinson RG, Young DB. The influence of cattle breed on susceptibility to bovine tuberculosis in Ethiopia. Comp Immunol Microbiol Infect Dis. 2012 May; 35(3):227-32. PMID: 22304898; PMCID: PMC3339321.
    5. Krishnan N, Malaga W, Constant P, Caws M, Tran TH, Salmons J, Nguyen TN, Nguyen DB, Daffé M, Young DB, Robertson BD, Guilhot C, Thwaites GE. Mycobacterium tuberculosis lineage influences innate immune response and virulence and is associated with distinct cell envelope lipid profiles. PLoS One. 2011; 6(9):e23870. PMID: 21931620; PMCID: PMC3169546.
    6. Martinez-Gamboa A, Ponce-de-Leon A, Galindo-Fraga A, Bobadilla-del-Valle M, Kato-Maeda M, Robertson BD, Young DB, Small PM, Sifuentes-Osornio J. Molecular analysis of Mycobacterium tuberculosis strains with an intact pks15/1 gene in a rural community of Mexico. Arch Med Res. 2008 Nov; 39(8):809-14. PMID: 18996296.
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    7. Young SK, Ponnighaus JM, Jain S, Lucas S, Suneetha S, Lockwood DN, Young DB, Fine PE. Use of short tandem repeat sequences to study Mycobacterium leprae in leprosy patients in Malawi and India. PLoS Negl Trop Dis. 2008 Apr 09; 2(4):e214. PMID: 18398487; PMCID: PMC2271132.
    8. Thanky NR, Young DB, Robertson BD. Unusual features of the cell cycle in mycobacteria: polar-restricted growth and the snapping-model of cell division. Tuberculosis (Edinb). 2007 May; 87(3):231-6. PMID: 17287144.
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    9. Stumpf MP, Robertson BD, Duncan K, Young DB. Systems biology and its impact on anti-infective drug development. Prog Drug Res. 2007; 64:1, 3-20. PMID: 17195469.
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    10. Stadthagen G, Jackson M, Charles P, Boudou F, Barilone N, Huerre M, Constant P, Liav A, Bottova I, Nigou J, Brando T, Puzo G, Daffé M, Benjamin P, Coade S, Buxton RS, Tascon RE, Rae A, Robertson BD, Lowrie DB, Young DB, Gicquel B, Griffin R. Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives. Microbes Infect. 2006 Jul; 8(8):2245-53. PMID: 16782391; PMCID: PMC2964916.
    11. Humphreys IR, Stewart GR, Turner DJ, Patel J, Karamanou D, Snelgrove RJ, Young DB. A role for dendritic cells in the dissemination of mycobacterial infection. Microbes Infect. 2006 Apr; 8(5):1339-46. PMID: 16697232.
      View in: PubMed
    12. Stewart GR, Patel J, Robertson BD, Rae A, Young DB. Mycobacterial mutants with defective control of phagosomal acidification. PLoS Pathog. 2005 Nov; 1(3):269-78. PMID: 16322769; PMCID: PMC1291353.
    13. Stewart GR, Wilkinson KA, Newton SM, Sullivan SM, Neyrolles O, Wain JR, Patel J, Pool KL, Young DB, Wilkinson RJ. Effect of deletion or overexpression of the 19-kilodalton lipoprotein Rv3763 on the innate response to Mycobacterium tuberculosis. Infect Immun. 2005 Oct; 73(10):6831-7. PMID: 16177361; PMCID: PMC1230982.
    14. Wiles S, Ferguson K, Stefanidou M, Young DB, Robertson BD. Alternative luciferase for monitoring bacterial cells under adverse conditions. Appl Environ Microbiol. 2005 Jul; 71(7):3427-32. PMID: 16000745; PMCID: PMC1169068.
    15. Taylor GM, Young DB, Mays SA. Genotypic analysis of the earliest known prehistoric case of tuberculosis in Britain. J Clin Microbiol. 2005 May; 43(5):2236-40. PMID: 15872248; PMCID: PMC1153742.
    16. Wilkinson KA, Stewart GR, Newton SM, Vordermeier HM, Wain JR, Murphy HN, Horner K, Young DB, Wilkinson RJ. Infection biology of a novel alpha-crystallin of Mycobacterium tuberculosis: Acr2. J Immunol. 2005 Apr 01; 174(7):4237-43. PMID: 15778386.
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    17. Godaly G, Young DB. Mycobacterium bovis bacille Calmette Guerin infection of human neutrophils induces CXCL8 secretion by MyD88-dependent TLR2 and TLR4 activation. Cell Microbiol. 2005 Apr; 7(4):591-601. PMID: 15760459.
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    18. Murphy HN, Stewart GR, Mischenko VV, Apt AS, Harris R, McAlister MS, Driscoll PC, Young DB, Robertson BD. The OtsAB pathway is essential for trehalose biosynthesis in Mycobacterium tuberculosis. J Biol Chem. 2005 Apr 15; 280(15):14524-9. PMID: 15703182.
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    19. Blokpoel MC, Murphy HN, O'Toole R, Wiles S, Runn ES, Stewart GR, Young DB, Robertson BD. Tetracycline-inducible gene regulation in mycobacteria. Nucleic Acids Res. 2005 Feb 01; 33(2):e22. PMID: 15687380; PMCID: PMC548381.
    20. Stewart GR, Newton SM, Wilkinson KA, Humphreys IR, Murphy HN, Robertson BD, Wilkinson RJ, Young DB. The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis. Mol Microbiol. 2005 Feb; 55(4):1127-37. PMID: 15686559.
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    21. Young SK, Taylor GM, Jain S, Suneetha LM, Suneetha S, Lockwood DN, Young DB. Microsatellite mapping of Mycobacterium leprae populations in infected humans. J Clin Microbiol. 2004 Nov; 42(11):4931-6. PMID: 15528676; PMCID: PMC525249.
    22. Kampmann B, Tena GN, Mzazi S, Eley B, Young DB, Levin M. Novel human in vitro system for evaluating antimycobacterial vaccines. Infect Immun. 2004 Nov; 72(11):6401-7. PMID: 15501770; PMCID: PMC522995.
    23. Stewart GR, Young DB. Heat-shock proteins and the host-pathogen interaction during bacterial infection. Curr Opin Immunol. 2004 Aug; 16(4):506-10. PMID: 15245747.
      View in: PubMed
    24. Stewart GR, Robertson BD, Young DB. Analysis of the function of mycobacterial DnaJ proteins by overexpression and microarray profiling. Tuberculosis (Edinb). 2004; 84(3-4):180-7. PMID: 15207487.
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    25. Stewart GR, Robertson BD, Young DB. Tuberculosis: a problem with persistence. Nat Rev Microbiol. 2003 Nov; 1(2):97-105. PMID: 15035039.
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    26. Young DB. Ten years of research progress and what's to come. Tuberculosis (Edinb). 2003; 83(1-3):77-81. PMID: 12758193.
      View in: PubMed
    27. Stewart GR, Wernisch L, Stabler R, Mangan JA, Hinds J, Laing KG, Young DB, Butcher PD. Dissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays. Microbiology. 2002 Oct; 148(Pt 10):3129-38. PMID: 12368446.
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    28. Turner DJ, Hoyle SL, Snewin VA, Gares MP, Brown IN, Young DB. An ex vivo culture model for screening drug activity against in vivo phenotypes of Mycobacterium tuberculosis. Microbiology. 2002 Oct; 148(Pt 10):2929-36. PMID: 12368426.
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    29. Young DB. Mycobacteria research in the post-genomic era. Microbiology. 2002 Oct; 148(Pt 10):2915-7. PMID: 12368424.
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    30. Mistry NF, Iyer AM, D'souza DT, Taylor GM, Young DB, Antia NH. Spoligotyping of Mycobacterium tuberculosis isolates from multiple-drug-resistant tuberculosis patients from Bombay, India. J Clin Microbiol. 2002 Jul; 40(7):2677-80. PMID: 12089307; PMCID: PMC120599.
    31. Young DB, Stewart GR. Tuberculosis vaccines. Br Med Bull. 2002; 62:73-86. PMID: 12176851.
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    32. Bunting KA, Cooper JB, Tickle IJ, Young DB. Engineering of an intersubunit disulfide bridge in the iron-superoxide dismutase of Mycobacterium tuberculosis. Arch Biochem Biophys. 2002 Jan 01; 397(1):69-76. PMID: 11747311.
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    33. Stewart GR, Wernisch L, Stabler R, Mangan JA, Hinds J, Laing KG, Butcher PD, Young DB. The heat shock response of Mycobacterium tuberculosis: linking gene expression, immunology and pathogenesis. Comp Funct Genomics. 2002; 3(4):348-51. PMID: 18629273; PMCID: PMC2448437.
    34. Dockrell HM, Brahmbhatt S, Robertson BD, Britton S, Fruth U, Gebre N, Hunegnaw M, Hussain R, Manandhar R, Murillo L, Pessolani MC, Roche P, Salgado JL, Sampaio E, Shahid F, Thole JE, Young DB. A postgenomic approach to identification of Mycobacterium leprae-specific peptides as T-cell reagents. Infect Immun. 2000 Oct; 68(10):5846-55. PMID: 10992494; PMCID: PMC101546.
    35. Young DB. New tools for tuberculosis control: do we really need them? Int J Tuberc Lung Dis. 1997 Jun; 1(3):193-5. PMID: 9432363.
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