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Dr Sara Lustigman

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Turner HC, Walker M, Lustigman S, Taylor DW, Basáñez MG. Human Onchocerciasis: Modelling the Potential Long-term Consequences of a Vaccination Programme. PLoS Negl Trop Dis. 2015; 9(7):e0003938. PMID: 26186715; PMCID: PMC4506122.
    2. Makepeace BL, Babayan SA, Lustigman S, Taylor DW. The case for vaccine development in the strategy to eradicate river blindness (onchocerciasis) from Africa. Expert Rev Vaccines. 2015; 14(9):1163-5. PMID: 26091691.
      View in: PubMed
    3. Liu C, Voronin D, Poole CB, Bachu S, Rogers MB, Jin J, Ghedin E, Lustigman S, McReynolds LA, Unnasch TR. Functional analysis of microRNA activity in Brugia malayi. Int J Parasitol. 2015 Aug; 45(9-10):579-83. PMID: 26004246; PMCID: PMC4490087.
    4. Guo J, Yang Y, Xiao W, Sun W, Yu H, Du L, Lustigman S, Jiang S, Kou Z, Zhou Y. A truncated fragment of Ov-ASP-1 consisting of the core pathogenesis-related-1 (PR-1) domain maintains adjuvanticity as the full-length protein. Vaccine. 2015 Apr 15; 33(16):1974-80. PMID: 25736195.
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    5. Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari JA. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003534. PMID: 25700363; PMCID: PMC4336141.
    6. Hotez PJ, Bottazzi ME, Zhan B, Makepeace BL, Klei TR, Abraham D, Taylor DW, Lustigman S. The Onchocerciasis Vaccine for Africa--TOVA--Initiative. PLoS Negl Trop Dis. 2015 Jan; 9(1):e0003422. PMID: 25634641; PMCID: PMC4310604.
    7. Gooyit M, Tricoche N, Javor S, Lustigman S, Janda KD. Exploiting the Polypharmacology of ß-Carbolines to Disrupt O. volvulus Molting. ACS Med Chem Lett. 2015 Mar 12; 6(3):339-43. PMID: 25815157; PMCID: PMC4360149.
    8. Lustigman S, Melnikow E, Anand SB, Contreras A, Nandi V, Liu J, Bell A, Unnasch TR, Rogers MB, Ghedin E. Potential involvement of Brugia malayi cysteine proteases in the maintenance of the endosymbiotic relationship with Wolbachia. Int J Parasitol Drugs Drug Resist. 2014 Dec; 4(3):267-77. PMID: 25516837; PMCID: PMC4266806.
    9. Gooyit M, Tricoche N, Lustigman S, Janda KD. Dual protonophore-chitinase inhibitors dramatically affect O. volvulus molting. J Med Chem. 2014 Jul 10; 57(13):5792-9. PMID: 24918716; PMCID: PMC4216208.
    10. Hotez PJ, Bottazzi ME, Tseng CT, Zhan B, Lustigman S, Du L, Jiang S. Calling for rapid development of a safe and effective MERS vaccine. Microbes Infect. 2014 Jul; 16(7):529-31. PMID: 24931059.
      View in: PubMed
    11. Arumugam S, Wei J, Ward D, Abraham D, Lustigman S, Zhan B, Klei TR. Vaccination with a genetically modified Brugia malayi cysteine protease inhibitor-2 reduces adult parasite numbers and affects the fertility of female worms following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae. Int J Parasitol. 2014 Sep; 44(10):675-9. PMID: 24929131.
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    12. Hess JA, Zhan B, Bonne-Année S, Deckman JM, Bottazzi ME, Hotez PJ, Klei TR, Lustigman S, Abraham D. Vaccines to combat river blindness: expression, selection and formulation of vaccines against infection with Onchocerca volvulus in a mouse model. Int J Parasitol. 2014 Aug; 44(9):637-46. PMID: 24907553; PMCID: PMC4118642.
    13. Jiang J, Fisher EM, Hensley SE, Lustigman S, Murasko DM, Shen H. Antigen sparing and enhanced protection using a novel rOv-ASP-1 adjuvant in aqueous formulation with influenza vaccines. Vaccine. 2014 May 13; 32(23):2696-702. PMID: 24681229; PMCID: PMC4080630.
    14. Arumugam S, Zhan B, Abraham D, Ward D, Lustigman S, Klei TR. Vaccination with recombinant Brugia malayi cystatin proteins alters worm migration, homing and final niche selection following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae. Parasit Vectors. 2014 Jan 22; 7:43. PMID: 24450869; PMCID: PMC3910689.
    15. Chen WH, Du L, Chag SM, Ma C, Tricoche N, Tao X, Seid CA, Hudspeth EM, Lustigman S, Tseng CT, Bottazzi ME, Hotez PJ, Zhan B, Jiang S. Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate. Hum Vaccin Immunother. 2014; 10(3):648-58. PMID: 24355931; PMCID: PMC4130269.
    16. Melnikow E, Xu S, Liu J, Bell AJ, Ghedin E, Unnasch TR, Lustigman S. A potential role for the interaction of Wolbachia surface proteins with the Brugia malayi glycolytic enzymes and cytoskeleton in maintenance of endosymbiosis. PLoS Negl Trop Dis. 2013; 7(4):e2151. PMID: 23593519; PMCID: PMC3617236.
    17. Jiang S, Bottazzi ME, Du L, Lustigman S, Tseng CT, Curti E, Jones K, Zhan B, Hotez PJ. Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome. Expert Rev Vaccines. 2012 Dec; 11(12):1405-13. PMID: 23252385; PMCID: PMC3586247.
    18. Lopez-Perez M, Villasis E, Machado RL, Póvoa MM, Vinetz JM, Blair S, Gamboa D, Lustigman S. Plasmodium falciparum field isolates from South America use an atypical red blood cell invasion pathway associated with invasion ligand polymorphisms. PLoS One. 2012; 7(10):e47913. PMID: 23118907; PMCID: PMC3485327.
    19. Villasis E, Lopez-Perez M, Torres K, Gamboa D, Neyra V, Bendezu J, Tricoche N, Lobo C, Vinetz JM, Lustigman S. Anti-Plasmodium falciparum invasion ligand antibodies in a low malaria transmission region, Loreto, Peru. Malar J. 2012 Oct 30; 11:361. PMID: 23110555; PMCID: PMC3544580.
    20. Gopal H, Hassan HK, Rodríguez-Pérez MA, Toé LD, Lustigman S, Unnasch TR. Oligonucleotide based magnetic bead capture of Onchocerca volvulus DNA for PCR pool screening of vector black flies. PLoS Negl Trop Dis. 2012; 6(6):e1712. PMID: 22724041; PMCID: PMC3378604.
    21. Wang J, Tricoche N, Du L, Hunter M, Zhan B, Goud G, Didier ES, Liu J, Lu L, Marx PA, Jiang S, Lustigman S. The adjuvanticity of an O. volvulus-derived rOv-ASP-1 protein in mice using sequential vaccinations and in non-human primates. PLoS One. 2012; 7(5):e37019. PMID: 22615877; PMCID: PMC3355165.
    22. Osei-Atweneboana MY, Lustigman S, Prichard RK, Boatin BA, Basáñez MG. A research agenda for helminth diseases of humans: health research and capacity building in disease-endemic countries for helminthiases control. PLoS Negl Trop Dis. 2012; 6(4):e1602. PMID: 22545167; PMCID: PMC3335878.
    23. Boatin BA, Basáñez MG, Prichard RK, Awadzi K, Barakat RM, García HH, Gazzinelli A, Grant WN, McCarthy JS, N'Goran EK, Osei-Atweneboana MY, Sripa B, Yang GJ, Lustigman S. A research agenda for helminth diseases of humans: towards control and elimination. PLoS Negl Trop Dis. 2012; 6(4):e1547. PMID: 22545161; PMCID: PMC3335858.
    24. Lustigman S, Prichard RK, Gazzinelli A, Grant WN, Boatin BA, McCarthy JS, Basáñez MG. A research agenda for helminth diseases of humans: the problem of helminthiases. PLoS Negl Trop Dis. 2012; 6(4):e1582. PMID: 22545164; PMCID: PMC3335854.
    25. Prichard RK, Basáñez MG, Boatin BA, McCarthy JS, García HH, Yang GJ, Sripa B, Lustigman S. A research agenda for helminth diseases of humans: intervention for control and elimination. PLoS Negl Trop Dis. 2012; 6(4):e1549. PMID: 22545163; PMCID: PMC3335868.
    26. Lustigman S, Geldhof P, Grant WN, Osei-Atweneboana MY, Sripa B, Basáñez MG. A research agenda for helminth diseases of humans: basic research and enabling technologies to support control and elimination of helminthiases. PLoS Negl Trop Dis. 2012; 6(4):e1445. PMID: 22545160; PMCID: PMC3335859.
    27. Basáñez MG, McCarthy JS, French MD, Yang GJ, Walker M, Gambhir M, Prichard RK, Churcher TS. A research agenda for helminth diseases of humans: modelling for control and elimination. PLoS Negl Trop Dis. 2012; 6(4):e1548. PMID: 22545162; PMCID: PMC3335861.
    28. McCarthy JS, Lustigman S, Yang GJ, Barakat RM, García HH, Sripa B, Willingham AL, Prichard RK, Basáñez MG. A research agenda for helminth diseases of humans: diagnostics for control and elimination programmes. PLoS Negl Trop Dis. 2012; 6(4):e1601. PMID: 22545166; PMCID: PMC3335877.
    29. Liu C, Kelen PV, Ghedin E, Lustigman S, Unnasch TR. Analysis of transcriptional regulation of tetracycline responsive genes in Brugia malayi. Mol Biochem Parasitol. 2011 Dec; 180(2):106-11. PMID: 21944995; PMCID: PMC3205945.
    30. Abraham D, Hess JA, Mejia R, Nolan TJ, Lok JB, Lustigman S, Nutman TB. Immunization with the recombinant antigen Ss-IR induces protective immunity to infection with Strongyloides stercoralis in mice. Vaccine. 2011 Oct 19; 29(45):8134-40. PMID: 21856350; PMCID: PMC3191285.
    31. Melnikow E, Xu S, Liu J, Li L, Oksov Y, Ghedin E, Unnasch TR, Lustigman S. Interaction of a Wolbachia WSP-like protein with a nuclear-encoded protein of Brugia malayi. Int J Parasitol. 2011 Aug 15; 41(10):1053-61. PMID: 21782817; PMCID: PMC3160744.
    32. Garner AL, Gloeckner C, Tricoche N, Zakhari JS, Samje M, Cho-Ngwa F, Lustigman S, Janda KD. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 09; 54(11):3963-72. PMID: 21534605.
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    33. Tarazona-Santos E, Castilho L, Amaral DR, Costa DC, Furlani NG, Zuccherato LW, Machado M, Reid ME, Zalis MG, Rossit AR, Santos SE, Machado RL, Lustigman S. Population genetics of GYPB and association study between GYPB*S/s polymorphism and susceptibility to P. falciparum infection in the Brazilian Amazon. PLoS One. 2011 Jan 24; 6(1):e16123. PMID: 21283638; PMCID: PMC3026040.
    34. Cho-Ngwa F, Liu J, Lustigman S. The Onchocerca volvulus cysteine proteinase inhibitor, Ov-CPI-2, is a target of protective antibody response that increases with age. PLoS Negl Trop Dis. 2010 Aug 24; 4(8):e800. PMID: 20808763; PMCID: PMC2927424.
    35. Zhao G, Du L, Xiao W, Sun S, Lin Y, Chen M, Kou Z, He Y, Lustigman S, Jiang S, Zheng BJ, Zhou Y. Induction of protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to Onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant. Vaccine. 2010 Oct 18; 28(44):7233-40. PMID: 20732469.
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    36. Zhan B, Perally S, Brophy PM, Xue J, Goud G, Liu S, Deumic V, de Oliveira LM, Bethony J, Bottazzi ME, Jiang D, Gillespie P, Xiao SH, Gupta R, Loukas A, Ranjit N, Lustigman S, Oksov Y, Hotez P. Molecular cloning, biochemical characterization, and partial protective immunity of the heme-binding glutathione S-transferases from the human hookworm Necator americanus. Infect Immun. 2010 Apr; 78(4):1552-63. PMID: 20145100; PMCID: PMC2849424.
    37. Gloeckner C, Garner AL, Mersha F, Oksov Y, Tricoche N, Eubanks LM, Lustigman S, Kaufmann GF, Janda KD. Repositioning of an existing drug for the neglected tropical disease Onchocerciasis. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3424-9. PMID: 20142509; PMCID: PMC2840490.
    38. Bergquist R, Lustigman S. Control of important helminthic infections vaccine development as part of the solution. Adv Parasitol. 2010; 73:297-326. PMID: 20627146.
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    39. Brindley PJ, Mitreva M, Ghedin E, Lustigman S. Helminth genomics: The implications for human health. PLoS Negl Trop Dis. 2009 Oct 26; 3(10):e538. PMID: 19855829; PMCID: PMC2757907.
    40. Ghedin E, Hailemariam T, DePasse JV, Zhang X, Oksov Y, Unnasch TR, Lustigman S. Brugia malayi gene expression in response to the targeting of the Wolbachia endosymbiont by tetracycline treatment. PLoS Negl Trop Dis. 2009 Oct 06; 3(10):e525. PMID: 19806204; PMCID: PMC2754610.
    41. He Y, Barker SJ, MacDonald AJ, Yu Y, Cao L, Li J, Parhar R, Heck S, Hartmann S, Golenbock DT, Jiang S, Libri NA, Semper AE, Rosenberg WM, Lustigman S. Recombinant Ov-ASP-1, a Th1-biased protein adjuvant derived from the helminth Onchocerca volvulus, can directly bind and activate antigen-presenting cells. J Immunol. 2009 Apr 01; 182(7):4005-16. PMID: 19299698.
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    42. Ford L, Zhang J, Liu J, Hashmi S, Fuhrman JA, Oksov Y, Lustigman S. Functional analysis of the cathepsin-like cysteine protease genes in adult Brugia malayi using RNA interference. PLoS Negl Trop Dis. 2009; 3(2):e377. PMID: 19190745; PMCID: PMC2634747.
    43. Guiliano DB, Oksov Y, Lustigman S, Gounaris K, Selkirk ME. Characterisation of novel protein families secreted by muscle stage larvae of Trichinella spiralis. Int J Parasitol. 2009 Apr; 39(5):515-24. PMID: 18992250; PMCID: PMC2680962.
    44. Rodriguez M, Lustigman S, Montero E, Oksov Y, Lobo CA. PfRH5: a novel reticulocyte-binding family homolog of plasmodium falciparum that binds to the erythrocyte, and an investigation of its receptor. PLoS One. 2008 Oct 01; 3(10):e3300. PMID: 18827878; PMCID: PMC2553180.
    45. Xiao W, Du L, Liang C, Guan J, Jiang S, Lustigman S, He Y, Zhou Y. Evaluation of recombinant Onchocerca volvulus activation associated protein-1 (ASP-1) as a potent Th1-biased adjuvant with a panel of protein or peptide-based antigens and commercial inactivated vaccines. Vaccine. 2008 Sep 15; 26(39):5022-9. PMID: 18675867; PMCID: PMC2597511.
    46. Jones MK, Lustigman S, Loukas A. Tracking the odysseys of juvenile schistosomes to understand host interactions. PLoS Negl Trop Dis. 2008 Jul 16; 2(7):e257. PMID: 18628997; PMCID: PMC2442878.
    47. MacDonald AJ, Libri NA, Lustigman S, Barker SJ, Whelan MA, Semper AE, Rosenberg WM. A novel, helminth-derived immunostimulant enhances human recall responses to hepatitis C virus and tetanus toxoid and is dependent on CD56+ cells for its action. Clin Exp Immunol. 2008 May; 152(2):265-73. PMID: 18341617; PMCID: PMC2384101.
    48. Al-Riyami L, Egan CA, Bradley JE, Lustigman S, Harnett W. Failure of ES-62 to inhibit T-helper type 1 responses to other filarial nematode antigens. Parasite Immunol. 2008 May; 30(5):304-8. PMID: 18312502.
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    49. Ford L, Lobo CA, Rodriguez M, Zalis MG, Machado RL, Rossit AR, Cavasini CE, Couto AA, Enyong PA, Lustigman S. Differential antibody responses to Plasmodium falciparum invasion ligand proteins in individuals living in malaria-endemic areas in Brazil and Cameroon. Am J Trop Med Hyg. 2007 Nov; 77(5):977-83. PMID: 17984363.
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    50. Berriman M, Lustigman S, McCarter JP. Genomics and emerging drug discovery technologies. Expert Opin Drug Discov. 2007 Oct; 2(s1):S83-9. PMID: 23489036.
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    51. Ghedin E, Wang S, Spiro D, Caler E, Zhao Q, Crabtree J, Allen JE, Delcher AL, Guiliano DB, Miranda-Saavedra D, Angiuoli SV, Creasy T, Amedeo P, Haas B, El-Sayed NM, Wortman JR, Feldblyum T, Tallon L, Schatz M, Shumway M, Koo H, Salzberg SL, Schobel S, Pertea M, Pop M, White O, Barton GJ, Carlow CK, Crawford MJ, Daub J, Dimmic MW, Estes CF, Foster JM, Ganatra M, Gregory WF, Johnson NM, Jin J, Komuniecki R, Korf I, Kumar S, Laney S, Li BW, Li W, Lindblom TH, Lustigman S, Ma D, Maina CV, Martin DM, McCarter JP, McReynolds L, Mitreva M, Nutman TB, Parkinson J, Peregrín-Alvarez JM, Poole C, Ren Q, Saunders L, Sluder AE, Smith K, Stanke M, Unnasch TR, Ware J, Wei AD, Weil G, Williams DJ, Zhang Y, Williams SA, Fraser-Liggett C, Slatko B, Blaxter ML, Scott AL. Draft genome of the filarial nematode parasite Brugia malayi. Science. 2007 Sep 21; 317(5845):1756-60. PMID: 17885136; PMCID: PMC2613796.
    52. Lustigman S, McCarter JP. Ivermectin resistance in Onchocerca volvulus: toward a genetic basis. PLoS Negl Trop Dis. 2007 Aug 30; 1(1):e76. PMID: 17989789; PMCID: PMC2041823.
    53. Fujiwara RT, Zhan B, Mendez S, Loukas A, Bueno LL, Wang Y, Plieskatt J, Oksov Y, Lustigman S, Bottazzi ME, Hotez P, Bethony JM. Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16. Clin Vaccine Immunol. 2007 Mar; 14(3):281-7. PMID: 17267592; PMCID: PMC1828853.
    54. Don TA, Oksov Y, Lustigman S, Loukas A. Saposin-like proteins from the intestine of the blood-feeding hookworm, Ancylostoma caninum. Parasitology. 2007 Mar; 134(Pt 3):427-36. PMID: 17109779.
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    55. Hashmi S, Zhang J, Oksov Y, Ji Q, Lustigman S. The Caenorhabditis elegans CPI-2a cystatin-like inhibitor has an essential regulatory role during oogenesis and fertilization. J Biol Chem. 2006 Sep 22; 281(38):28415-29. PMID: 16857685.
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    56. Lobo CA, Rodriguez M, Struchiner CJ, Zalis MG, Lustigman S. Associations between defined polymorphic variants in the PfRH ligand family and the invasion pathways used by P. falciparum field isolates from Brazil. Mol Biochem Parasitol. 2006 Oct; 149(2):246-51. PMID: 16857278.
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    57. He Y, Li J, Heck S, Lustigman S, Jiang S. Antigenic and immunogenic characterization of recombinant baculovirus-expressed severe acute respiratory syndrome coronavirus spike protein: implication for vaccine design. J Virol. 2006 Jun; 80(12):5757-67. PMID: 16731915; PMCID: PMC1472569.
    58. He Y, Li J, Li W, Lustigman S, Farzan M, Jiang S. Cross-neutralization of human and palm civet severe acute respiratory syndrome coronaviruses by antibodies targeting the receptor-binding domain of spike protein. J Immunol. 2006 May 15; 176(10):6085-92. PMID: 16670317.
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    59. Tchakouté VL, Graham SP, Jensen SA, Makepeace BL, Nfon CK, Njongmeta LM, Lustigman S, Enyong PA, Tanya VN, Bianco AE, Trees AJ. In a bovine model of onchocerciasis, protective immunity exists naturally, is absent in drug-cured hosts, and is induced by vaccination. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5971-6. PMID: 16585501; PMCID: PMC1458682.
    60. Williamson AL, Lustigman S, Oksov Y, Deumic V, Plieskatt J, Mendez S, Zhan B, Bottazzi ME, Hotez PJ, Loukas A. Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration. Infect Immun. 2006 Feb; 74(2):961-7. PMID: 16428741; PMCID: PMC1360348.
    61. Kerepesi LA, Leon O, Lustigman S, Abraham D. Protective immunity to the larval stages of onchocerca volvulus is dependent on Toll-like receptor 4. Infect Immun. 2005 Dec; 73(12):8291-7. PMID: 16299326; PMCID: PMC1307100.
    62. Ford L, Guiliano DB, Oksov Y, Debnath AK, Liu J, Williams SA, Blaxter ML, Lustigman S. Characterization of a novel filarial serine protease inhibitor, Ov-SPI-1, from Onchocerca volvulus, with potential multifunctional roles during development of the parasite. J Biol Chem. 2005 Dec 09; 280(49):40845-56. PMID: 16186127.
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    63. Bethony J, Loukas A, Smout M, Brooker S, Mendez S, Plieskatt J, Goud G, Bottazzi ME, Zhan B, Wang Y, Williamson A, Lustigman S, Correa-Oliveira R, Xiao S, Hotez PJ. Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals. FASEB J. 2005 Oct; 19(12):1743-5. PMID: 16037096.
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    64. MacDonald AJ, Cao L, He Y, Zhao Q, Jiang S, Lustigman S. rOv-ASP-1, a recombinant secreted protein of the helminth Onchocercavolvulus, is a potent adjuvant for inducing antibodies to ovalbumin, HIV-1 polypeptide and SARS-CoV peptide antigens. Vaccine. 2005 May 16; 23(26):3446-52. PMID: 15837368.
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    65. Lustigman S, Zhang J, Liu J, Oksov Y, Hashmi S. RNA interference targeting cathepsin L and Z-like cysteine proteases of Onchocerca volvulus confirmed their essential function during L3 molting. Mol Biochem Parasitol. 2004 Dec; 138(2):165-70. PMID: 15555728.
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    66. Lobo CA, de Frazao K, Rodriguez M, Reid M, Zalis M, Lustigman S. Invasion profiles of Brazilian field isolates of Plasmodium falciparum: phenotypic and genotypic analyses. Infect Immun. 2004 Oct; 72(10):5886-91. PMID: 15385490; PMCID: PMC517604.
    67. Guiliano DB, Hong X, McKerrow JH, Blaxter ML, Oksov Y, Liu J, Ghedin E, Lustigman S. A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling. Mol Biochem Parasitol. 2004 Aug; 136(2):227-42. PMID: 15478801.
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    68. Kerepesi LA, Nolan TJ, Schad GA, Lustigman S, Herbert DR, Keiser PB, Nutman TB, Krolewiecki AJ, Abraham D. Human immunoglobulin G mediates protective immunity and identifies protective antigens against larval Strongyloides stercoralis in mice. J Infect Dis. 2004 Apr 01; 189(7):1282-90. PMID: 15031798.
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    69. Abraham D, Leon O, Schnyder-Candrian S, Wang CC, Galioto AM, Kerepesi LA, Lee JJ, Lustigman S. Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae. Infect Immun. 2004 Feb; 72(2):810-7. PMID: 14742524; PMCID: PMC321619.
    70. MacDonald AJ, Tawe W, Leon O, Cao L, Liu J, Oksov Y, Abraham D, Lustigman S. Ov-ASP-1, the Onchocerca volvulus homologue of the activation associated secreted protein family is immunostimulatory and can induce protective anti-larval immunity. Parasite Immunol. 2004 Jan; 26(1):53-62. PMID: 15198646.
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    71. Ligas JA, Kerepesi LA, Galioto AM, Lustigman S, Nolan TJ, Schad GA, Abraham D. Specificity and mechanism of immunoglobulin M (IgM)- and IgG-dependent protective immunity to larval Strongyloides stercoralis in mice. Infect Immun. 2003 Dec; 71(12):6835-43. PMID: 14638770; PMCID: PMC308934.
    72. Hashmi S, Zhang J, Oksov Y, Lustigman S. The Caenorhabditis elegans cathepsin Z-like cysteine protease, Ce-CPZ-1, has a multifunctional role during the worms' development. J Biol Chem. 2004 Feb 13; 279(7):6035-45. PMID: 14630920.
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    73. Lustigman S, MacDonald AJ, Abraham D. CD4+-dependent immunity to Onchocerca volvulus third-stage larvae in humans and the mouse vaccination model: common ground and distinctions. Int J Parasitol. 2003 Sep 30; 33(11):1161-71. PMID: 13678632.
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    74. Lobo CA, Rodriguez M, Hou G, Perkins M, Oskov Y, Lustigman S. Characterization of PfRhop148, a novel rhoptry protein of Plasmodium falciparum. Mol Biochem Parasitol. 2003 Apr 25; 128(1):59-65. PMID: 12706797.
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    75. Lobo CA, Rodriguez M, Reid M, Lustigman S. Glycophorin C is the receptor for the Plasmodium falciparum erythrocyte binding ligand PfEBP-2 (baebl). Blood. 2003 Jun 01; 101(11):4628-31. PMID: 12576308.
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    76. MacDonald AJ, Turaga PS, Harmon-Brown C, Tierney TJ, Bennett KE, McCarthy MC, Simonek SC, Enyong PA, Moukatte DW, Lustigman S. Differential cytokine and antibody responses to adult and larval stages of Onchocerca volvulus consistent with the development of concomitant immunity. Infect Immun. 2002 Jun; 70(6):2796-804. PMID: 12010965; PMCID: PMC127981.
    77. Lustigman S, James ER, Tawe W, Abraham D. Towards a recombinant antigen vaccine against Onchocerca volvulus. Trends Parasitol. 2002 Mar; 18(3):135-41. PMID: 11854092.
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    78. Herbert DR, Nolan TJ, Schad GA, Lustigman S, Abraham D. Immunoaffinity-isolated antigens induce protective immunity against larval Strongyloides stercoralis in mice. Exp Parasitol. 2002 Feb; 100(2):112-20. PMID: 12054701.
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    79. McCarthy JS, Wieseman M, Tropea J, Kaslow D, Abraham D, Lustigman S, Tuan R, Guderian RH, Nutman TB. Onchocerca volvulus glycolytic enzyme fructose-1,6-bisphosphate aldolase as a target for a protective immune response in humans. Infect Immun. 2002 Feb; 70(2):851-8. PMID: 11796620; PMCID: PMC127653.
    80. Hashmi S, Britton C, Liu J, Guiliano DB, Oksov Y, Lustigman S. Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans. J Biol Chem. 2002 Feb 01; 277(5):3477-86. PMID: 11707440.
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    81. Hashmi S, Tawe W, Lustigman S. Caenorhabditis elegans and the study of gene function in parasites. Trends Parasitol. 2001 Aug; 17(8):387-93. PMID: 11685900.
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    82. Abraham D, Leon O, Leon S, Lustigman S. Development of a recombinant antigen vaccine against infection with the filarial worm Onchocerca volvulus. Infect Immun. 2001 Jan; 69(1):262-70. PMID: 11119514; PMCID: PMC97880.
    83. Tawe W, Pearlman E, Unnasch TR, Lustigman S. Angiogenic activity of Onchocerca volvulus recombinant proteins similar to vespid venom antigen 5. Mol Biochem Parasitol. 2000 Jul; 109(2):91-9. PMID: 10960168.
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    84. Lizotte-Waniewski M, Tawe W, Guiliano DB, Lu W, Liu J, Williams SA, Lustigman S. Identification of potential vaccine and drug target candidates by expressed sequence tag analysis and immunoscreening of Onchocerca volvulus larval cDNA libraries. Infect Immun. 2000 Jun; 68(6):3491-501. PMID: 10816503; PMCID: PMC97634.
    85. Vincent JA, Lustigman S, Zhang S, Weil GJ. A comparison of newer tests for the diagnosis of onchocerciasis. Ann Trop Med Parasitol. 2000 Apr; 94(3):253-8. PMID: 10884870.
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    86. Turaga PS, Tierney TJ, Bennett KE, McCarthy MC, Simonek SC, Enyong PA, Moukatte DW, Lustigman S. Immunity to onchocerciasis: cells from putatively immune individuals produce enhanced levels of interleukin-5, gamma interferon, and granulocyte-macrophage colony-stimulating factor in response to Onchocerca volvulus larval and male worm antigens. Infect Immun. 2000 Apr; 68(4):1905-11. PMID: 10722581; PMCID: PMC97365.
    87. Graham SP, Lustigman S, Trees AJ, Bianco AE. Onchocerca volvulus: comparative analysis of antibody responses to recombinant antigens in two animal models of onchocerciasis. Exp Parasitol. 2000 Mar; 94(3):158-62. PMID: 10831380.
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    88. Joseph GT, Huima T, Klion A, Lustigman S. A novel developmentally regulated galectin of Onchocerca volvulus. Mol Biochem Parasitol. 2000 Feb 25; 106(1):187-95. PMID: 10743624.
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    89. Graham SP, Wu Y, Henkle-Duehrsen K, Lustigman S, Unnasch TR, Braun G, Williams SA, McCarthy J, Trees AJ, Bianco AE. Patterns of Onchocerca volvulus recombinant antigen recognition in a bovine model of onchocerciasis. Parasitology. 1999 Dec; 119 ( Pt 6):603-12. PMID: 10633922.
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    90. McKerrow JH, Huima T, Lustigman S. Do filarid nematodes have a vascular system? Parasitol Today. 1999 Mar; 15(3):123. PMID: 10322327.
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    91. Joseph GT, Huima T, Lustigman S. Characterization of an Onchocerca volvulus L3-specific larval antigen, Ov-ALT-1. Mol Biochem Parasitol. 1998 Oct 30; 96(1-2):177-83. PMID: 9851616.
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    92. Johnson EH, Schynder-Candrian S, Rajan TV, Nelson FK, Lustigman S, Abraham D. Immune responses to third stage larvae of Onchocerca volvulus in interferon-gamma and interleukin-4 knockout mice. Parasite Immunol. 1998 Jul; 20(7):319-24. PMID: 9717193.
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    93. Joseph GT, McCarthy JS, Huima T, Mair KF, Kass PH, Boussinesq M, Goodrick L, Bradley JE, Lustigman S. Onchocera volvulus: characterization of a highly immunogenic Gln-rich protein. Mol Biochem Parasitol. 1997 Dec 01; 90(1):55-68. PMID: 9497032.
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    94. Zhao XJ, Lustigman S, Li YS, Kenney ME, Ben-Hur E. Structure-activity and mechanism studies on silicon phthalocyanines with Plasmodium falciparum in the dark and under red light. Photochem Photobiol. 1997 Aug; 66(2):282-7. PMID: 9277150.
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    95. Irvine M, Johnson EH, Lustigman S. Identification of larval-stage-specific antigens of Onchocerca volvulus uniquely recognized by putative immune sera from humans and vaccination sera from animal models. Ann Trop Med Parasitol. 1997 Jan; 91(1):67-77. PMID: 9093431.
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    96. Lustigman S, McKerrow JH, Shah K, Lui J, Huima T, Hough M, Brotman B. Cloning of a cysteine protease required for the molting of Onchocerca volvulus third stage larvae. J Biol Chem. 1996 Nov 22; 271(47):30181-9. PMID: 8939969.
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    97. Radice AD, Lustigman S. Cloning and characterization of cDNAs encoding putative glutamate transporters from Caenorhabditis elegans and Onchocerca volvulus. Mol Biochem Parasitol. 1996 Sep; 80(1):41-53. PMID: 8885221.
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    98. Lustigman S, Ben-Hur E. Photosensitized inactivation of Plasmodium falciparum in human red cells by phthalocyanines. Transfusion. 1996 Jun; 36(6):543-6. PMID: 8669087.
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    99. Ben-Hur E, Moor AC, Margolis-Nunno H, Gottlieb P, Zuk MM, Lustigman S, Horowitz B, Brand A, Van Steveninck J, Dubbelman TM. The photodecontamination of cellular blood components: mechanisms and use of photosensitization in transfusion medicine. Transfus Med Rev. 1996 Jan; 10(1):15-22. PMID: 8787927.
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    100. Lustigman S, Brotman B, Huima T, Castelhano AL, Singh RN, Mehta K, Prince AM. Transglutaminase-catalyzed reaction is important for molting of Onchocerca volvulus third-stage larvae. Antimicrob Agents Chemother. 1995 Sep; 39(9):1913-9. PMID: 8540691; PMCID: PMC162856.
    101. Johnson EH, Lustigman S, Kass PH, Irvine M, Browne J, Prince AM. Onchocerca volvulus: a comparative study of in vitro neutrophil killing of microfilariae and humoral responses in infected and endemic normals. Exp Parasitol. 1995 Aug; 81(1):9-19. PMID: 7628571.
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    102. Johnson EH, Irvine M, Kass PH, Browne J, Abdullai M, Prince AM, Lustigman S. Onchocerca volvulus: in vitro cytotoxic effects of human neutrophils and serum on third-stage larvae. Trop Med Parasitol. 1994 Dec; 45(4):331-5. PMID: 7716398.
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    103. Gillespie AJ, Lustigman S, Rivas-Alcala AR, Bradley JE. The effect of ivermectin treatment on the antibody response to antigens of Onchocerca volvulus. Trans R Soc Trop Med Hyg. 1994 Jul-Aug; 88(4):456-60. PMID: 7570844.
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    104. Irvine M, Huima T, Prince AM, Lustigman S. Identification and characterization of an Onchocerca volvulus cDNA clone encoding a highly immunogenic calponin-like protein. Mol Biochem Parasitol. 1994 May; 65(1):135-46. PMID: 7935620.
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    105. Chandrashekar R, Ogunrinade AF, Henry RW, Lustigman S, Weil GJ. Onchocerca volvulus: monoclonal antibodies to immune complex-associated parasite antigens. Exp Parasitol. 1993 Sep; 77(2):224-34. PMID: 7690712.
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    106. Lustigman S. Molting, enzymes and new targets for chemotherapy of Onchocerca volvulus. Parasitol Today. 1993 Aug; 9(8):294-7. PMID: 15463786.
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    107. Lustigman S, Brotman B, Huima T, Prince AM, McKerrow JH. Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus. J Biol Chem. 1992 Aug 25; 267(24):17339-46. PMID: 1512269.
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    108. Prince AM, Brotman B, Johnson EH, Smith A, Pascual D, Lustigman S. Onchocerca volvulus: immunization of chimpanzees with X-irradiated third-stage (L3) larvae. Exp Parasitol. 1992 May; 74(3):239-50. PMID: 1582477.
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    109. Lustigman S, Brotman B, Johnson EH, Smith AB, Huima T, Prince AM. Identification and characterization of an Onchocerca volvulus cDNA clone encoding a microfilarial surface-associated antigen. Mol Biochem Parasitol. 1992 Jan; 50(1):79-93. PMID: 1542318.
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    110. Johnson EH, Lustigman S, Brotman B, Browne J, Prince AM. Onchocerca volvulus: in vitro killing of microfilaria by neutrophils and eosinophils from experimentally infected chimpanzees. Trop Med Parasitol. 1991 Dec; 42(4):351-5. PMID: 1796232.
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    111. Miller KM, Lustigman S, Brotman B, Andrus L, Weiss N, Hotze C, Prince AM. Onchocerca volvulus: characterization of monoclonal antibodies reactive with surface components of third-stage larvae. Trop Med Parasitol. 1991 Jun; 42(2):85-90. PMID: 1896779.
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    112. Lustigman S, Brotman B, Huima T, Prince AM. Characterization of an Onchocerca volvulus cDNA clone encoding a genus specific antigen present in infective larvae and adult worms. Mol Biochem Parasitol. 1991 Mar; 45(1):65-75. PMID: 2052041.
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    113. Lustigman S, Huima T, Brotman B, Miller K, Prince AM. Onchocerca volvulus: biochemical and morphological characteristics of the surface of third- and fourth-stage larvae. Exp Parasitol. 1990 Nov; 71(4):489-95. PMID: 2226709.
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    114. Lustigman S, Anders RF, Brown GV, Coppel RL. The mature-parasite-infected erythrocyte surface antigen (MESA) of Plasmodium falciparum associates with the erythrocyte membrane skeletal protein, band 4.1. Mol Biochem Parasitol. 1990 Jan 15; 38(2):261-70. PMID: 2183050.
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    115. Coppel RL, Lustigman S, Murray L, Anders RF. MESA is a Plasmodium falciparum phosphoprotein associated with the erythrocyte membrane skeleton. Mol Biochem Parasitol. 1988 Dec; 31(3):223-31. PMID: 3065643.
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    116. Lustigman S, Anders RF, Brown GV, Coppel RL. A component of an antigenic rhoptry complex of Plasmodium falciparum is modified after merozoite invasion. Mol Biochem Parasitol. 1988 Sep; 30(3):217-24. PMID: 3054533.
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    117. Lustigman S, Mahmoud AA, Hamburger J. Glycopeptides in soluble egg antigen of Schistosoma mansoni: isolation, characterization, and elucidation of their immunochemical and immunopathological relation to the major egg glycoprotein (MEG). J Immunol. 1985 Mar; 134(3):1961-7. PMID: 3918114.
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    118. Lustigman S, Hamburger J. Schistosoma mansoni: radiometric assay of lectin binding specificities of the major egg glycoprotein and its carbohydrate-rich fragment. Exp Parasitol. 1985 Feb; 59(1):59-67. PMID: 3838155.
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    119. Hamburger J, Moscovici H, Lustigman S. The use of lyophilized Schistosoma mansoni eggs as antigenic particles in a radioimmunoassay. J Helminthol. 1983 Dec; 57(4):305-12. PMID: 6366044.
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    120. Wertheim G, Lustigman S, Silberman H, Shoshan S. Demonstration of collagenase activity in adult Strongyloides ratti (Nematoda:Strongyloididae) and its absence in the infective larvae. J Helminthol. 1983 Sep; 57(3):241-6. PMID: 6313800.
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    121. Hamburger J, Lustigman S, Siongok TK, Ouma JH, Mahmoud AA. Analysis and preliminary purification of glycoproteins isolated from eggs in the urine of patients with Schistosoma haematobium infection. J Immunol. 1982 Oct; 129(4):1711-4. PMID: 7202027.
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    122. Hamburger J, Lustigman S, Siongok TK, Ouma JH, Mahmoud AA. Characterization of a purified glycoprotein from Schistosoma mansoni eggs: specificity, stability, and the involvement of carbohydrate and peptide moieties in its serologic activity. J Immunol. 1982 Apr; 128(4):1864-9. PMID: 6174618.
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