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Professor Patrick De Baetselier

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Van Overmeire E, Stijlemans B, Heymann F, Keirsse J, Morias Y, Elkrim Y, Brys L, Abels C, Lahmar Q, Ergen C, Vereecke L, Tacke F, De Baetselier P, Van Ginderachter JA, Laoui D. M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment. Cancer Res. 2016 Jan 01; 76(1):35-42. PMID: 26573801.
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    2. Goyvaerts C, Broos K, Escors D, Heirman C, Raes G, De Baetselier P, Thielemans K, Breckpot K. The transduction pattern of IL-12-encoding lentiviral vectors shapes the immunological outcome. Eur J Immunol. 2015 Dec; 45(12):3351-61. PMID: 26377033.
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    3. Van den Bossche J, Laoui D, Naessens T, Smits HH, Hokke CH, Stijlemans B, Grooten J, De Baetselier P, Van Ginderachter JA. E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo. Sci Rep. 2015 Jul 31; 5:12599. PMID: 26226941; PMCID: PMC4521155.
    4. Blykers A, Schoonooghe S, Xavier C, D'hoe K, Laoui D, D'Huyvetter M, Vaneycken I, Cleeren F, Bormans G, Heemskerk J, Raes G, De Baetselier P, Lahoutte T, Devoogdt N, Van Ginderachter JA, Caveliers V. PET Imaging of Macrophage Mannose Receptor-Expressing Macrophages in Tumor Stroma Using 18F-Radiolabeled Camelid Single-Domain Antibody Fragments. J Nucl Med. 2015 Aug; 56(8):1265-71. PMID: 26069306.
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    5. Morias Y, Abels C, Laoui D, Van Overmeire E, Guilliams M, Schouppe E, Tacke F, deVries CJ, De Baetselier P, Beschin A. Ly6C- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C+ Monocytes into Macrophages. PLoS Pathog. 2015 May; 11(5):e1004873. PMID: 26020782; PMCID: PMC4447383.
    6. Stijlemans B, Beschin A, Magez S, Van Ginderachter JA, De Baetselier P. Iron Homeostasis and Trypanosoma brucei Associated Immunopathogenicity Development: A Battle/Quest for Iron. Biomed Res Int. 2015; 2015:819389. PMID: 26090446; PMCID: PMC4450282.
    7. Van Gassen N, Van Overmeire E, Leuckx G, Heremans Y, De Groef S, Cai Y, Elkrim Y, Gysemans C, Stijlemans B, Van de Casteele M, De Baetselier P, De Leu N, Heimberg H, Van Ginderachter JA. Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas. Eur J Immunol. 2015 May; 45(5):1482-93. PMID: 25645754.
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    8. Stijlemans B, Cnops J, Naniima P, Vaast A, Bockstal V, De Baetselier P, Magez S. Development of a pHrodo-based assay for the assessment of in vitro and in vivo erythrophagocytosis during experimental trypanosomosis. PLoS Negl Trop Dis. 2015 Mar; 9(3):e0003561. PMID: 25742307; PMCID: PMC4352936.
    9. Laoui D, Van Overmeire E, De Baetselier P, Van Ginderachter JA, Raes G. Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression. Front Immunol. 2014; 5:489. PMID: 25339957; PMCID: PMC4188035.
    10. Zheng F, Devoogdt N, Sparkes A, Morias Y, Abels C, Stijlemans B, Lahoutte T, Muyldermans S, De Baetselier P, Schoonooghe S, Beschin A, Raes G. Monitoring liver macrophages using nanobodies targeting Vsig4: concanavalin A induced acute hepatitis as paradigm. Immunobiology. 2015 Feb; 220(2):200-9. PMID: 25440182.
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    11. Stijlemans B, Leng L, Brys L, Sparkes A, Vansintjan L, Caljon G, Raes G, Van Den Abbeele J, Van Ginderachter JA, Beschin A, Bucala R, De Baetselier P. MIF contributes to Trypanosoma brucei associated immunopathogenicity development. PLoS Pathog. 2014 Sep; 10(9):e1004414. PMID: 25255103; PMCID: PMC4177988.
    12. Beschin A, Van Den Abbeele J, De Baetselier P, Pays E. African trypanosome control in the insect vector and mammalian host. Trends Parasitol. 2014 Nov; 30(11):538-47. PMID: 25246021.
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    13. Van den Bergh R, Van Ginderachter JA, Schouppe E, Desimmie BA, Hailu A, De Baetselier P, van Griensven J. Visceral leishmaniasis relapse in HIV patients--a role for myeloid-derived suppressor cells? PLoS Negl Trop Dis. 2014 Sep; 8(9):e3132. PMID: 25210932; PMCID: PMC4161322.
    14. Zheng F, Put S, Bouwens L, Lahoutte T, Matthys P, Muyldermans S, De Baetselier P, Devoogdt N, Raes G, Schoonooghe S. Molecular imaging with macrophage CRIg-targeting nanobodies for early and preclinical diagnosis in a mouse model of rheumatoid arthritis. J Nucl Med. 2014 May; 55(5):824-9. PMID: 24686780.
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    15. Goyvaerts C, Kurt de G, Van Lint S, Heirman C, Van Ginderachter JA, De Baetselier P, Raes G, Thielemans K, Breckpot K. Immunogenicity of targeted lentivectors. Oncotarget. 2014 Feb 15; 5(3):704-15. PMID: 24519916; PMCID: PMC3996667.
    16. Laoui D, Van Overmeire E, Di Conza G, Aldeni C, Keirsse J, Morias Y, Movahedi K, Houbracken I, Schouppe E, Elkrim Y, Karroum O, Jordan B, Carmeliet P, Gysemans C, De Baetselier P, Mazzone M, Van Ginderachter JA. Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population. Cancer Res. 2014 Jan 01; 74(1):24-30. PMID: 24220244.
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    17. De Muylder G, Daulouède S, Lecordier L, Uzureau P, Morias Y, Van Den Abbeele J, Caljon G, Hérin M, Holzmuller P, Semballa S, Courtois P, Vanhamme L, Stijlemans B, De Baetselier P, Barrett MP, Barlow JL, McKenzie AN, Barron L, Wynn TA, Beschin A, Vincendeau P, Pays E. A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity. PLoS Pathog. 2013 Oct; 9(10):e1003731. PMID: 24204274; PMCID: PMC3814429.
    18. Schouppe E, Mommer C, Movahedi K, Laoui D, Morias Y, Gysemans C, Luyckx A, De Baetselier P, Van Ginderachter JA. Tumor-induced myeloid-derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8+ T-cell activation events. Eur J Immunol. 2013 Nov; 43(11):2930-42. PMID: 23878002.
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    19. Tran HT, Van den Bergh R, Vu TN, Laukens K, Worodria W, Loembé MM, Colebunders R, Kestens L, De Baetselier P, Raes G. The role of monocytes in the development of Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome. Immunobiology. 2014 Jan; 219(1):37-44. PMID: 23958034.
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    20. Goyvaerts C, Dingemans J, De Groeve K, Heirman C, Van Gulck E, Vanham G, De Baetselier P, Thielemans K, Raes G, Breckpot K. Targeting of human antigen-presenting cell subsets. J Virol. 2013 Oct; 87(20):11304-8. PMID: 23864630; PMCID: PMC3807283.
    21. Tran HT, Van den Bergh R, Loembé MM, Worodria W, Mayanja-Kizza H, Colebunders R, Mascart F, Stordeur P, Kestens L, De Baetselier P, Raes G. Modulation of the complement system in monocytes contributes to tuberculosis-associated immune reconstitution inflammatory syndrome. AIDS. 2013 Jul 17; 27(11):1725-34. PMID: 23807270.
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    22. Put S, Schoonooghe S, Devoogdt N, Schurgers E, Avau A, Mitera T, D'Huyvetter M, De Baetselier P, Raes G, Lahoutte T, Matthys P. SPECT imaging of joint inflammation with Nanobodies targeting the macrophage mannose receptor in a mouse model for rheumatoid arthritis. J Nucl Med. 2013 May; 54(5):807-14. PMID: 23447654.
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    23. Beschin A, De Baetselier P, Van Ginderachter JA. Contribution of myeloid cell subsets to liver fibrosis in parasite infection. J Pathol. 2013 Jan; 229(2):186-97. PMID: 23011901.
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    24. Caljon G, Stijlemans B, Saerens D, Van Den Abbeele J, Muyldermans S, Magez S, De Baetselier P. Affinity is an important determinant of the anti-trypanosome activity of nanobodies. PLoS Negl Trop Dis. 2012; 6(11):e1902. PMID: 23166849; PMCID: PMC3499403.
    25. Caljon G, De Ridder K, Stijlemans B, Coosemans M, Magez S, De Baetselier P, Van Den Abbeele J. Tsetse salivary gland proteins 1 and 2 are high affinity nucleic acid binding proteins with residual nuclease activity. PLoS One. 2012; 7(10):e47233. PMID: 23110062; PMCID: PMC3479092.
    26. Raes G, De Baetselier P, Van Ginderachter JA. Plasticity of monocytes, macrophages and dendritic cells is reflected in distinct organs and tissues. Immunobiology. 2012 Dec; 217(12):1223-4. PMID: 23084370.
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    27. Schoonooghe S, Laoui D, Van Ginderachter JA, Devoogdt N, Lahoutte T, De Baetselier P, Raes G. Novel applications of nanobodies for in vivo bio-imaging of inflamed tissues in inflammatory diseases and cancer. Immunobiology. 2012 Dec; 217(12):1266-72. PMID: 22884356.
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    28. Movahedi K, Schoonooghe S, Laoui D, Houbracken I, Waelput W, Breckpot K, Bouwens L, Lahoutte T, De Baetselier P, Raes G, Devoogdt N, Van Ginderachter JA. Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages. Cancer Res. 2012 Aug 15; 72(16):4165-77. PMID: 22719068.
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    29. Salmon D, Vanwalleghem G, Morias Y, Denoeud J, Krumbholz C, Lhommé F, Bachmaier S, Kador M, Gossmann J, Dias FB, De Muylder G, Uzureau P, Magez S, Moser M, De Baetselier P, Van Den Abbeele J, Beschin A, Boshart M, Pays E. Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host. Science. 2012 Jul 27; 337(6093):463-6. PMID: 22700656.
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    30. Van den Bergh R, Morin S, Sass HJ, Grzesiek S, Vekemans M, Florence E, Tran HT, Imiru RG, Heyndrickx L, Vanham G, De Baetselier P, Raes G. Monocytes contribute to differential immune pressure on R5 versus X4 HIV through the adipocytokine visfatin/NAMPT. PLoS One. 2012; 7(4):e35074. PMID: 22493731; PMCID: PMC3320877.
    31. Van den Bossche J, Lamers WH, Koehler ES, Geuns JM, Alhonen L, Uimari A, Pirnes-Karhu S, Van Overmeire E, Morias Y, Brys L, Vereecke L, De Baetselier P, Van Ginderachter JA. Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes. J Leukoc Biol. 2012 May; 91(5):685-99. PMID: 22416259.
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    32. De Vooght L, Caljon G, Stijlemans B, De Baetselier P, Coosemans M, Van den Abbeele J. Expression and extracellular release of a functional anti-trypanosome Nanobody® in Sodalis glossinidius, a bacterial symbiont of the tsetse fly. Microb Cell Fact. 2012 Feb 15; 11:23. PMID: 22335892; PMCID: PMC3311065.
    33. Devoogdt N, Xavier C, Hernot S, Vaneycken I, D'Huyvetter M, De Vos J, Massa S, De Baetselier P, Caveliers V, Lahoutte T. Molecular imaging using Nanobodies: a case study. Methods Mol Biol. 2012; 911:559-67. PMID: 22886276.
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    34. Raes G, De Baetselier P, Van Ginderachter JA. Clinical and fundamental aspects of monocyte, macrophage and dendritic cell plasticity. Eur J Immunol. 2012 Jan; 42(1):13-6. PMID: 22213043.
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    35. Van den Bossche J, Malissen B, Mantovani A, De Baetselier P, Van Ginderachter JA. Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs. Blood. 2012 Feb 16; 119(7):1623-33. PMID: 22174153.
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    36. Pletinckx K, Stijlemans B, Pavlovic V, Laube R, Brandl C, Kneitz S, Beschin A, De Baetselier P, Lutz MB. Similar inflammatory DC maturation signatures induced by TNF or Trypanosoma brucei antigens instruct default Th2-cell responses. Eur J Immunol. 2011 Dec; 41(12):3479-94. PMID: 21928284.
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    37. Boonefaes T, Houthuys E, Van den Bergh R, Vander Beken S, Raes G, Brouckaert P, De Baetselier P, Grooten J. Do-it-yourself: construction of a custom cDNA macroarray platform with high sensitivity and linear range. BMC Biotechnol. 2011 Oct 25; 11:97. PMID: 22026914; PMCID: PMC3217856.
    38. Bosschaerts T, Morias Y, Stijlemans B, Hérin M, Porta C, Sica A, Mantovani A, De Baetselier P, Beschin A. IL-10 limits production of pathogenic TNF by M1 myeloid cells through induction of nuclear NF-?B p50 member in Trypanosoma congolense infection-resistant C57BL/6 mice. Eur J Immunol. 2011 Nov; 41(11):3270-80. PMID: 21805465.
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    39. Cuervo H, Guerrero NA, Carbajosa S, Beschin A, De Baetselier P, Gironès N, Fresno M. Myeloid-derived suppressor cells infiltrate the heart in acute Trypanosoma cruzi infection. J Immunol. 2011 Sep 01; 187(5):2656-65. PMID: 21804013.
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    40. Laoui D, Van Overmeire E, Movahedi K, Van den Bossche J, Schouppe E, Mommer C, Nikolaou A, Morias Y, De Baetselier P, Van Ginderachter JA. Mononuclear phagocyte heterogeneity in cancer: different subsets and activation states reaching out at the tumor site. Immunobiology. 2011 Nov; 216(11):1192-202. PMID: 21803441.
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    41. Stijlemans B, Caljon G, Natesan SK, Saerens D, Conrath K, Pérez-Morga D, Skepper JN, Nikolaou A, Brys L, Pays E, Magez S, Field MC, De Baetselier P, Muyldermans S. High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis. PLoS Pathog. 2011 Jun; 7(6):e1002072. PMID: 21698216; PMCID: PMC3116811.
    42. Laoui D, Movahedi K, Van Overmeire E, Van den Bossche J, Schouppe E, Mommer C, Nikolaou A, Morias Y, De Baetselier P, Van Ginderachter JA. Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions. Int J Dev Biol. 2011; 55(7-9):861-7. PMID: 22161841.
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    43. Van Ginderachter JA, Beschin A, De Baetselier P, Raes G. Myeloid-derived suppressor cells in parasitic infections. Eur J Immunol. 2010 Nov; 40(11):2976-85. PMID: 21061431.
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    44. Bosschaerts T, Guilliams M, Stijlemans B, Morias Y, Engel D, Tacke F, Hérin M, De Baetselier P, Beschin A. Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2, IFN-gamma and MyD88 signaling. PLoS Pathog. 2010 Aug 12; 6(8):e1001045. PMID: 20714353; PMCID: PMC2920868.
    45. Movahedi K, Laoui D, Gysemans C, Baeten M, Stangé G, Van den Bossche J, Mack M, Pipeleers D, In't Veld P, De Baetselier P, Van Ginderachter JA. Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res. 2010 Jul 15; 70(14):5728-39. PMID: 20570887.
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    46. Vankrunkelsven A, De Ceulaer K, Hsu D, Liu FT, De Baetselier P, Stijlemans B. Lack of galectin-3 alleviates trypanosomiasis-associated anemia of inflammation. Immunobiology. 2010 Sep-Oct; 215(9-10):833-41. PMID: 20605052.
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    47. Vaneycken I, Govaert J, Vincke C, Caveliers V, Lahoutte T, De Baetselier P, Raes G, Bossuyt A, Muyldermans S, Devoogdt N. In vitro analysis and in vivo tumor targeting of a humanized, grafted nanobody in mice using pinhole SPECT/micro-CT. J Nucl Med. 2010 Jul; 51(7):1099-106. PMID: 20554727.
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    48. Van den Bergh R, Florence E, Vlieghe E, Boonefaes T, Grooten J, Houthuys E, Tran HT, Gali Y, De Baetselier P, Vanham G, Raes G. Transcriptome analysis of monocyte-HIV interactions. Retrovirology. 2010 Jun 14; 7:53. PMID: 20546557; PMCID: PMC2900222.
    49. Van Den Abbeele J, Caljon G, De Ridder K, De Baetselier P, Coosemans M. Trypanosoma brucei modifies the tsetse salivary composition, altering the fly feeding behavior that favors parasite transmission. PLoS Pathog. 2010 Jun 03; 6(6):e1000926. PMID: 20532213; PMCID: PMC2880569.
    50. Houthuys E, Movahedi K, De Baetselier P, Van Ginderachter JA, Brouckaert P. A method for the isolation and purification of mouse peripheral blood monocytes. J Immunol Methods. 2010 Jul 31; 359(1-2):1-10. PMID: 20457160.
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    51. Deschacht N, De Groeve K, Vincke C, Raes G, De Baetselier P, Muyldermans S. A novel promiscuous class of camelid single-domain antibody contributes to the antigen-binding repertoire. J Immunol. 2010 May 15; 184(10):5696-704. PMID: 20404276.
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    52. De Groeve K, Deschacht N, De Koninck C, Caveliers V, Lahoutte T, Devoogdt N, Muyldermans S, De Baetselier P, Raes G. Nanobodies as tools for in vivo imaging of specific immune cell types. J Nucl Med. 2010 May; 51(5):782-9. PMID: 20395332.
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    53. Caljon G, De Ridder K, De Baetselier P, Coosemans M, Van Den Abbeele J. Identification of a tsetse fly salivary protein with dual inhibitory action on human platelet aggregation. PLoS One. 2010 Mar 23; 5(3):e9671. PMID: 20351782; PMCID: PMC2843633.
    54. Stijlemans B, Vankrunkelsven A, Caljon G, Bockstal V, Guilliams M, Bosschaerts T, Beschin A, Raes G, Magez S, De Baetselier P. The central role of macrophages in trypanosomiasis-associated anemia: rationale for therapeutical approaches. Endocr Metab Immune Disord Drug Targets. 2010 Mar; 10(1):71-82. PMID: 20158497.
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    55. Stijlemans B, Vankrunkelsven A, Brys L, Raes G, Magez S, De Baetselier P. Scrutinizing the mechanisms underlying the induction of anemia of inflammation through GPI-mediated modulation of macrophage activation in a model of African trypanosomiasis. Microbes Infect. 2010 May; 12(5):389-99. PMID: 20197106.
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    56. Gómez-Rodríguez J, Stijlemans B, De Muylder G, Korf H, Brys L, Berberof M, Darji A, Pays E, De Baetselier P, Beschin A. Identification of a parasitic immunomodulatory protein triggering the development of suppressive M1 macrophages during African trypanosomiasis. J Infect Dis. 2009 Dec 15; 200(12):1849-60. PMID: 19911988.
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    57. Huang L, De Baetselier P, Beyaert R. Targeting the EGF receptor ectodomain in the context of cancer. Expert Opin Ther Targets. 2009 Nov; 13(11):1347-61. PMID: 19769546.
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    58. Van den Bossche J, Bogaert P, van Hengel J, Guérin CJ, Berx G, Movahedi K, Van den Bergh R, Pereira-Fernandes A, Geuns JM, Pircher H, Dorny P, Grooten J, De Baetselier P, Van Ginderachter JA. Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes. Blood. 2009 Nov 19; 114(21):4664-74. PMID: 19726720.
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    59. Porta C, Rimoldi M, Raes G, Brys L, Ghezzi P, Di Liberto D, Dieli F, Ghisletti S, Natoli G, De Baetselier P, Mantovani A, Sica A. Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB. Proc Natl Acad Sci U S A. 2009 Sep 01; 106(35):14978-83. PMID: 19706447; PMCID: PMC2736429.
    60. Bosschaerts T, Guilliams M, Stijlemans B, De Baetselier P, Beschin A. Understanding the role of monocytic cells in liver inflammation using parasite infection as a model. Immunobiology. 2009; 214(9-10):737-47. PMID: 19577324.
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    61. Namangala B, DE Baetselier P, Beschin A. Quantitative differences in immune responses in mouse strains that differ in their susceptibility to Trypanosoma brucei brucei infection. J Vet Med Sci. 2009 Jul; 71(7):951-6. PMID: 19652484.
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    62. Caljon G, Broos K, De Goeyse I, De Ridder K, Sternberg JM, Coosemans M, De Baetselier P, Guisez Y, Den Abbeele JV. Identification of a functional Antigen5-related allergen in the saliva of a blood feeding insect, the tsetse fly. Insect Biochem Mol Biol. 2009 May-Jun; 39(5-6):332-41. PMID: 19507303.
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    63. Namangala B, De Baetselier P, Beschin A. Both type-I and type-II responses contribute to murine trypanotolerance. J Vet Med Sci. 2009 Mar; 71(3):313-8. PMID: 19346699.
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    64. Guilliams M, Movahedi K, Bosschaerts T, VandenDriessche T, Chuah MK, Hérin M, Acosta-Sanchez A, Ma L, Moser M, Van Ginderachter JA, Brys L, De Baetselier P, Beschin A. IL-10 dampens TNF/inducible nitric oxide synthase-producing dendritic cell-mediated pathogenicity during parasitic infection. J Immunol. 2009 Jan 15; 182(2):1107-18. PMID: 19124754.
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    65. Stijlemans B, Vankrunkelsven A, Brys L, Magez S, De Baetselier P. Role of iron homeostasis in trypanosomiasis-associated anemia. Immunobiology. 2008; 213(9-10):823-35. PMID: 18926297.
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    66. Guilliams M, Bosschaerts T, Hérin M, Hünig T, Loi P, Flamand V, De Baetselier P, Beschin A. Experimental expansion of the regulatory T cell population increases resistance to African trypanosomiasis. J Infect Dis. 2008 Sep 01; 198(5):781-91. PMID: 18627271.
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    67. Magez S, Schwegmann A, Atkinson R, Claes F, Drennan M, De Baetselier P, Brombacher F. The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice. PLoS Pathog. 2008 Aug 08; 4(8):e1000122. PMID: 18688274; PMCID: PMC2483930.
    68. Bosschaerts T, Guilliams M, Noel W, Hérin M, Burk RF, Hill KE, Brys L, Raes G, Ghassabeh GH, De Baetselier P, Beschin A. Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P. J Immunol. 2008 May 01; 180(9):6168-75. PMID: 18424738.
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    69. Gainkam LO, Huang L, Caveliers V, Keyaerts M, Hernot S, Vaneycken I, Vanhove C, Revets H, De Baetselier P, Lahoutte T. Comparison of the biodistribution and tumor targeting of two 99mTc-labeled anti-EGFR nanobodies in mice, using pinhole SPECT/micro-CT. J Nucl Med. 2008 May; 49(5):788-95. PMID: 18413403.
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    70. Huang L, Gainkam LO, Caveliers V, Vanhove C, Keyaerts M, De Baetselier P, Bossuyt A, Revets H, Lahoutte T. SPECT imaging with 99mTc-labeled EGFR-specific nanobody for in vivo monitoring of EGFR expression. Mol Imaging Biol. 2008 May-Jun; 10(3):167-75. PMID: 18297364.
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    71. Movahedi K, Guilliams M, Van den Bossche J, Van den Bergh R, Gysemans C, Beschin A, De Baetselier P, Van Ginderachter JA. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood. 2008 Apr 15; 111(8):4233-44. PMID: 18272812.
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    72. Gartner T, Romano M, Suin V, Kalai M, Korf H, De Baetselier P, Huygen K. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine co-expressing pro-apoptotic caspase-3. Vaccine. 2008 Mar 10; 26(11):1458-70. PMID: 18280621.
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    73. Van Ginderachter JA, Movahedi K, Van den Bossche J, De Baetselier P. Macrophages, PPARs, and Cancer. PPAR Res. 2008; 2008:169414. PMID: 18615187; PMCID: PMC2443396.
    74. Raes G, Ghassabeh GH, Brys L, Mpofu N, Verschueren H, Vanhecke D, De Baetselier P. The metastatic T-cell hybridoma antigen/P-selectin glycoprotein ligand 1 is required for hematogenous metastasis of lymphomas. Int J Cancer. 2007 Dec 15; 121(12):2646-52. PMID: 17721882.
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    75. Saerens D, Stijlemans B, Baral TN, Nguyen Thi GT, Wernery U, Magez S, De Baetselier P, Muyldermans S, Conrath K. Parallel selection of multiple anti-infectome Nanobodies without access to purified antigens. J Immunol Methods. 2008 Jan 01; 329(1-2):138-50. PMID: 17996887.
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    76. Barber MA, Zhang T, Gagne BA, Van Ginderachter JA, De Baetselier P, Sentman CL. Ly49G2 receptor blockade reduces tumor burden in a leukemia model but not in a solid tumor model. Cancer Immunol Immunother. 2008 May; 57(5):655-62. PMID: 17891395.
      View in: PubMed
    77. Stijlemans B, Baral TN, Guilliams M, Brys L, Korf J, Drennan M, Van Den Abbeele J, De Baetselier P, Magez S. A glycosylphosphatidylinositol-based treatment alleviates trypanosomiasis-associated immunopathology. J Immunol. 2007 Sep 15; 179(6):4003-14. PMID: 17785839.
      View in: PubMed
    78. Guilliams M, Oldenhove G, Noel W, Hérin M, Brys L, Loi P, Flamand V, Moser M, De Baetselier P, Beschin A. African trypanosomiasis: naturally occurring regulatory T cells favor trypanotolerance by limiting pathology associated with sustained type 1 inflammation. J Immunol. 2007 Sep 01; 179(5):2748-57. PMID: 17709488.
      View in: PubMed
    79. Magez S, Radwanska M, Drennan M, Fick L, Baral TN, Allie N, Jacobs M, Nedospasov S, Brombacher F, Ryffel B, De Baetselier P. Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage-derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing. J Infect Dis. 2007 Sep 15; 196(6):954-62. PMID: 17703428.
      View in: PubMed
    80. Gay CG, Richie TL, Pastoret PP, Minguez-Tudela I, de Baetselier P, Göbel T, Goddeeris B, Kaiser P, Morrison I, Sánchez-Vizcaíno JM, Anderson K, Baillie LW, Brown WC, Estes DM, Herrera E, Nara PL, Ockenhouse CF, Roth JA, Sztein MB. Advances in immunology and vaccine discovery report of the United States-European Commission workshop. Vaccine. 2007 Oct 10; 25(41):7007-11. PMID: 17728022.
      View in: PubMed
    81. Raes G, Beschin A, Ghassabeh GH, De Baetselier P. Alternatively activated macrophages in protozoan infections. Curr Opin Immunol. 2007 Aug; 19(4):454-9. PMID: 17628461.
      View in: PubMed
    82. Stijlemans B, Guilliams M, Raes G, Beschin A, Magez S, De Baetselier P. African trypanosomosis: from immune escape and immunopathology to immune intervention. Vet Parasitol. 2007 Aug 19; 148(1):3-13. PMID: 17560035.
      View in: PubMed
    83. Gartner T, Baeten M, Otieno S, Revets H, De Baetselier P, Huygen K. Mucosal prime-boost vaccination for tuberculosis based on TLR triggering OprI lipoprotein from Pseudomonas aeruginosa fused to mycolyl-transferase Ag85A. Immunol Lett. 2007 Jul 31; 111(1):26-35. PMID: 17570535.
      View in: PubMed
    84. Copin R, De Baetselier P, Carlier Y, Letesson JJ, Muraille E. MyD88-dependent activation of B220-CD11b+LY-6C+ dendritic cells during Brucella melitensis infection. J Immunol. 2007 Apr 15; 178(8):5182-91. PMID: 17404301.
      View in: PubMed
    85. Baral TN, De Baetselier P, Brombacher F, Magez S. Control of Trypanosoma evansi infection is IgM mediated and does not require a type I inflammatory response. J Infect Dis. 2007 May 15; 195(10):1513-20. PMID: 17436232.
      View in: PubMed
    86. Devoogdt N, Revets H, Kindt A, Liu YQ, De Baetselier P, Ghassabeh GH. The tumor-promoting effect of TNF-alpha involves the induction of secretory leukocyte protease inhibitor. J Immunol. 2006 Dec 01; 177(11):8046-52. PMID: 17114478.
      View in: PubMed
    87. Baral TN, Magez S, Stijlemans B, Conrath K, Vanhollebeke B, Pays E, Muyldermans S, De Baetselier P. [Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor]. Med Sci (Paris). 2006 Nov; 22(11):914-6. PMID: 17101086.
      View in: PubMed
    88. Bilej M, Josková R, Van den Bergh R, Procházková P, Silerová M, Ameloot P, De Baetselier P, Beschin A. An invertebrate TNF functional analogue activates macrophages via lectin-saccharide interaction with ion channels. Int Immunol. 2006 Dec; 18(12):1663-70. PMID: 17035350.
      View in: PubMed
    89. Caljon G, Van Den Abbeele J, Stijlemans B, Coosemans M, De Baetselier P, Magez S. Tsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory response. Infect Immun. 2006 Nov; 74(11):6324-30. PMID: 16954393; PMCID: PMC1695494.
    90. Van Ginderachter JA, Movahedi K, Hassanzadeh Ghassabeh G, Meerschaut S, Beschin A, Raes G, De Baetselier P. Classical and alternative activation of mononuclear phagocytes: picking the best of both worlds for tumor promotion. Immunobiology. 2006; 211(6-8):487-501. PMID: 16920488.
      View in: PubMed
    91. Caljon G, Van Den Abbeele J, Sternberg JM, Coosemans M, De Baetselier P, Magez S. Tsetse fly saliva biases the immune response to Th2 and induces anti-vector antibodies that are a useful tool for exposure assessment. Int J Parasitol. 2006 Aug; 36(9):1025-35. PMID: 16777113.
      View in: PubMed
    92. Korf JE, Pynaert G, Tournoy K, Boonefaes T, Van Oosterhout A, Ginneberge D, Haegeman A, Verschoor JA, De Baetselier P, Grooten J. Macrophage reprogramming by mycolic acid promotes a tolerogenic response in experimental asthma. Am J Respir Crit Care Med. 2006 Jul 15; 174(2):152-60. PMID: 16675779.
      View in: PubMed
    93. Procházková P, Silerová M, Stijlemans B, Dieu M, Halada P, Josková R, Beschin A, De Baetselier P, Bilej M. Evidence for proteins involved in prophenoloxidase cascade Eisenia fetida earthworms. J Comp Physiol B. 2006 Aug; 176(6):581-7. PMID: 16636833.
      View in: PubMed
    94. Magez S, Radwanska M, Drennan M, Fick L, Baral TN, Brombacher F, De Baetselier P. Interferon-gamma and nitric oxide in combination with antibodies are key protective host immune factors during trypanosoma congolense Tc13 Infections. J Infect Dis. 2006 Jun 01; 193(11):1575-83. PMID: 16652287.
      View in: PubMed
    95. Baral TN, Magez S, Stijlemans B, Conrath K, Vanhollebeke B, Pays E, Muyldermans S, De Baetselier P. Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor. Nat Med. 2006 May; 12(5):580-4. PMID: 16604085.
      View in: PubMed
    96. Ghassabeh GH, De Baetselier P, Brys L, Noël W, Van Ginderachter JA, Meerschaut S, Beschin A, Brombacher F, Raes G. Identification of a common gene signature for type II cytokine-associated myeloid cells elicited in vivo in different pathologic conditions. Blood. 2006 Jul 15; 108(2):575-83. PMID: 16556895.
      View in: PubMed
    97. Van Ginderachter JA, Meerschaut S, Liu Y, Brys L, De Groeve K, Hassanzadeh Ghassabeh G, Raes G, De Baetselier P. Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands reverse CTL suppression by alternatively activated (M2) macrophages in cancer. Blood. 2006 Jul 15; 108(2):525-35. PMID: 16527895.
      View in: PubMed
    98. Van den Bergh R, Vanham G, Raes G, De Baetselier P, Colebunders R. Mycobacterium-associated immune reconstitution disease: macrophages running wild? Lancet Infect Dis. 2006 Jan; 6(1):2-3; author reply 4-5. PMID: 16377524.
      View in: PubMed
    99. Silerová M, Procházková P, Josková R, Josens G, Beschin A, De Baetselier P, Bilej M. Comparative study of the CCF-like pattern recognition protein in different Lumbricid species. Dev Comp Immunol. 2006; 30(9):765-71. PMID: 16386303.
      View in: PubMed
    100. Drennan MB, Stijlemans B, Van den Abbeele J, Quesniaux VJ, Barkhuizen M, Brombacher F, De Baetselier P, Ryffel B, Magez S. The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent. J Immunol. 2005 Aug 15; 175(4):2501-9. PMID: 16081822.
      View in: PubMed
    101. Procházková P, Silerová M, Felsberg J, Josková R, Beschin A, De Baetselier P, Bilej M. Relationship between hemolytic molecules in Eisenia fetida earthworms. Dev Comp Immunol. 2006; 30(4):381-92. PMID: 16051356.
      View in: PubMed
    102. Raes G, Van den Bergh R, De Baetselier P, Ghassabeh GH, Scotton C, Locati M, Mantovani A, Sozzani S. Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells. J Immunol. 2005 Jun 01; 174(11):6561; author reply 6561-2. PMID: 15905489.
      View in: PubMed
    103. Brys L, Beschin A, Raes G, Ghassabeh GH, Noël W, Brandt J, Brombacher F, De Baetselier P. Reactive oxygen species and 12/15-lipoxygenase contribute to the antiproliferative capacity of alternatively activated myeloid cells elicited during helminth infection. J Immunol. 2005 May 15; 174(10):6095-104. PMID: 15879104.
      View in: PubMed
    104. Korf J, Stoltz A, Verschoor J, De Baetselier P, Grooten J. The Mycobacterium tuberculosis cell wall component mycolic acid elicits pathogen-associated host innate immune responses. Eur J Immunol. 2005 Mar; 35(3):890-900. PMID: 15724242.
      View in: PubMed
    105. Revets H, Pynaert G, Grooten J, De Baetselier P. Lipoprotein I, a TLR2/4 ligand modulates Th2-driven allergic immune responses. J Immunol. 2005 Jan 15; 174(2):1097-103. PMID: 15634935.
      View in: PubMed
    106. Revets H, De Baetselier P, Muyldermans S. Nanobodies as novel agents for cancer therapy. Expert Opin Biol Ther. 2005 Jan; 5(1):111-24. PMID: 15709914.
      View in: PubMed
    107. Raes G, Brys L, Dahal BK, Brandt J, Grooten J, Brombacher F, Vanham G, Noël W, Bogaert P, Boonefaes T, Kindt A, Van den Bergh R, Leenen PJ, De Baetselier P, Ghassabeh GH. Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation. J Leukoc Biol. 2005 Mar; 77(3):321-7. PMID: 15591125.
      View in: PubMed
    108. Devoogdt N, Revets H, Ghassabeh GH, De Baetselier P. Secretory leukocyte protease inhibitor in cancer development. Ann N Y Acad Sci. 2004 Dec; 1028:380-9. PMID: 15650263.
      View in: PubMed
    109. Köhlerová P, Beschin A, Silerová M, De Baetselier P, Bilej M. Effect of experimental microbial challenge on the expression of defense molecules in Eisenia foetida earthworm. Dev Comp Immunol. 2004 Jun; 28(7-8):701-11. PMID: 15043940.
      View in: PubMed
    110. Cortez-Retamozo V, Backmann N, Senter PD, Wernery U, De Baetselier P, Muyldermans S, Revets H. Efficient cancer therapy with a nanobody-based conjugate. Cancer Res. 2004 Apr 15; 64(8):2853-7. PMID: 15087403.
      View in: PubMed
    111. Noël W, Raes G, Hassanzadeh Ghassabeh G, De Baetselier P, Beschin A. Alternatively activated macrophages during parasite infections. Trends Parasitol. 2004 Mar; 20(3):126-33. PMID: 15036034.
      View in: PubMed
    112. Magez S, Truyens C, Merimi M, Radwanska M, Stijlemans B, Brouckaert P, Brombacher F, Pays E, De Baetselier P. P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasis. J Infect Dis. 2004 Feb 01; 189(3):527-39. PMID: 14745712.
      View in: PubMed
    113. Stijlemans B, Conrath K, Cortez-Retamozo V, Van Xong H, Wyns L, Senter P, Revets H, De Baetselier P, Muyldermans S, Magez S. Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm. J Biol Chem. 2004 Jan 09; 279(2):1256-61. PMID: 14527957.
      View in: PubMed
    114. Elia N, Tapponnier M, Matthay MA, Hamacher J, Pache JC, Brundler MA, Totsch M, De Baetselier P, Fransen L, Fukuda N, Morel DR, Lucas R. Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha. Am J Respir Crit Care Med. 2003 Nov 01; 168(9):1043-50. PMID: 12842853.
      View in: PubMed
    115. De Meyer K, De Baetselier P, Verschueren H, Geldhof AB. Morphometric analysis of cytolysis in cultured cell monolayers: a simple and versatile method for the evaluation of the lytic activity and the fate of LAK cells. J Immunol Methods. 2003 Jun 01; 277(1-2):193-211. PMID: 12799051.
      View in: PubMed
    116. Geldhof AB, van Ginderachter JA, Liu Y, Noël W, de Baetselier P. Ablation of NK cell function during tumor growth favors Type 2-associated macrophages, leading to suppressed CTL generation. Clin Dev Immunol. 2003 Jun-Dec; 10(2-4):71-81. PMID: 14768937; PMCID: PMC2485417.
    117. Liu Y, Van Ginderachter JA, Brys L, De Baetselier P, Raes G, Geldhof AB. Nitric oxide-independent CTL suppression during tumor progression: association with arginase-producing (M2) myeloid cells. J Immunol. 2003 May 15; 170(10):5064-74. PMID: 12734351.
      View in: PubMed
    118. Devoogdt N, Hassanzadeh Ghassabeh G, Zhang J, Brys L, De Baetselier P, Revets H. Secretory leukocyte protease inhibitor promotes the tumorigenic and metastatic potential of cancer cells. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5778-82. PMID: 12732717; PMCID: PMC156277.
    119. Muraille E, De Trez C, Pajak B, Torrentera FA, De Baetselier P, Leo O, Carlier Y. Amastigote load and cell surface phenotype of infected cells from lesions and lymph nodes of susceptible and resistant mice infected with Leishmania major. Infect Immun. 2003 May; 71(5):2704-15. PMID: 12704145; PMCID: PMC153240.
    120. Muraille E, De Trez C, Brait M, De Baetselier P, Leo O, Carlier Y. Genetically resistant mice lacking MyD88-adapter protein display a high susceptibility to Leishmania major infection associated with a polarized Th2 response. J Immunol. 2003 Apr 15; 170(8):4237-41. PMID: 12682257.
      View in: PubMed
    121. Vanhamme L, Paturiaux-Hanocq F, Poelvoorde P, Nolan DP, Lins L, Van Den Abbeele J, Pays A, Tebabi P, Van Xong H, Jacquet A, Moguilevsky N, Dieu M, Kane JP, De Baetselier P, Brasseur R, Pays E. Apolipoprotein L-I is the trypanosome lytic factor of human serum. Nature. 2003 Mar 06; 422(6927):83-7. PMID: 12621437.
      View in: PubMed
    122. Radwanska M, Chamekh M, Vanhamme L, Claes F, Magez S, Magnus E, de Baetselier P, Büscher P, Pays E. The serum resistance-associated gene as a diagnostic tool for the detection of Trypanosoma brucei rhodesiense. Am J Trop Med Hyg. 2002 Dec; 67(6):684-90. PMID: 12518862.
      View in: PubMed
    123. Beschin A, De Baetselier P, Bilej M. CCF, an invertebrate analogue of TNF, is not related to the other lytic components from Eisenia foetida earthworm. Bioessays. 2002 Oct; 24(10):974; author reply 975-6. PMID: 12325130.
      View in: PubMed
    124. Xong HV, De Baetselier P, Pays E, Magez S. Selective pressure can influence the resistance of Trypanosoma congolense to normal human serum. Exp Parasitol. 2002 Oct; 102(2):61-5. PMID: 12706740.
      View in: PubMed
    125. Raes G, Noël W, Beschin A, Brys L, de Baetselier P, Hassanzadeh GH. FIZZ1 and Ym as tools to discriminate between differentially activated macrophages. Dev Immunol. 2002 Sep; 9(3):151-9. PMID: 12892049; PMCID: PMC2276098.
    126. Geldhof AB, Van Ginderachter JA, Liu Y, Noël W, Raes G, De Baetselier P. Antagonistic effect of NK cells on alternatively activated monocytes: a contribution of NK cells to CTL generation. Blood. 2002 Dec 01; 100(12):4049-58. PMID: 12393627.
      View in: PubMed
    127. Magez S, Stijlemans B, Baral T, De Baetselier P. VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathology. Microbes Infect. 2002 Jul; 4(9):999-1006. PMID: 12106794.
      View in: PubMed
    128. Ameloot P, Fiers W, Buurman WA, de Baetselier P, Brouckaert P. Characterization of the interaction between murine tumour necrosis factor and monoclonal antibodies. Cytokine. 2002 May 07; 18(3):158-63. PMID: 12126652.
      View in: PubMed
    129. Raes G, De Baetselier P, Noël W, Beschin A, Brombacher F, Hassanzadeh Gh G. Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages. J Leukoc Biol. 2002 Apr; 71(4):597-602. PMID: 11927645.
      View in: PubMed
    130. Cortez-Retamozo V, Lauwereys M, Hassanzadeh Gh G, Gobert M, Conrath K, Muyldermans S, De Baetselier P, Revets H. Efficient tumor targeting by single-domain antibody fragments of camels. Int J Cancer. 2002 Mar 20; 98(3):456-62. PMID: 11920600.
      View in: PubMed
    131. Bloc A, Lucas R, Van Dijck E, Bilej M, Dunant Y, De Baetselier P, Beschin A. An invertebrate defense molecule activates membrane conductance in mammalian cells by means of its lectin-like domain. Dev Comp Immunol. 2002 Jan; 26(1):35-43. PMID: 11687261.
      View in: PubMed
    132. Olivares Fontt E, Beschin A, Van Dijck E, Vercruysse V, Bilej M, Lucas R, De Baetselier P, Vray B. Trypanosoma cruzi is lysed by coelomic cytolytic factor-1, an invertebrate analogue of tumor necrosis factor, and induces phenoloxidase activity in the coelomic fluid of Eisenia foetida foetida. Dev Comp Immunol. 2002 Jan; 26(1):27-34. PMID: 11687260.
      View in: PubMed
    133. Cote-Sierra J, Bredan A, Toldos CM, Stijlemans B, Brys L, Cornelis P, Segovia M, de Baetselier P, Revets H. Bacterial lipoprotein-based vaccines induce tumor necrosis factor-dependent type 1 protective immunity against Leishmania major. Infect Immun. 2002 Jan; 70(1):240-8. PMID: 11748189; PMCID: PMC127619.
    134. Geldhof AB, De Meyer K, De Baetselier P, Verschueren H. Morphometric analysis of cytolysis in cultured cell monolayers: a simple and versatile method for the evaluation of the cytotoxic activity and the fate of LAK cells. Lab Invest. 2002 Jan; 82(1):105-7. PMID: 11796831.
      View in: PubMed
    135. Remels LM, De Baetselier PC. Characterization of 3LL-tumor variants generated by in vitro macrophage-mediated selection. Int J Cancer. 1987 Mar 15; 39(3):343-52. PMID: 3818124.
      View in: PubMed
    136. Smet EG, De Smet W, Brys L, De Baetselier PC. Mab. 198: a monoclonal antibody recognizing the complement type 3 receptor (CR3) in the rabbit. Immunology. 1986 Nov; 59(3):419-25. PMID: 3793137; PMCID: PMC1453192.
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