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Dr Jacques Le Bras

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    1. Houzé S, Hoang NT, Lozach O, Le Bras J, Meijer L, Galons H, Demange L. Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, are new anti-malarial agents. Molecules. 2014 Sep 23; 19(9):15237-57. PMID: 25251193.
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    2. Cottrell G, Musset L, Hubert V, Le Bras J, Clain J. Emergence of resistance to atovaquone-proguanil in malaria parasites: insights from computational modeling and clinical case reports. Antimicrob Agents Chemother. 2014 Aug; 58(8):4504-14. PMID: 24867967; PMCID: PMC4136057.
    3. Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois AC, Khim N, Kim S, Duru V, Bouchier C, Ma L, Lim P, Leang R, Duong S, Sreng S, Suon S, Chuor CM, Bout DM, Ménard S, Rogers WO, Genton B, Fandeur T, Miotto O, Ringwald P, Le Bras J, Berry A, Barale JC, Fairhurst RM, Benoit-Vical F, Mercereau-Puijalon O, Ménard D. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature. 2014 Jan 02; 505(7481):50-5. PMID: 24352242; PMCID: PMC5007947.
    4. Gaillard T, Briolant S, Houzé S, Baragatti M, Wurtz N, Hubert V, Lavina M, Pascual A, Travaillé C, Le Bras J, Pradines B. PftetQ and pfmdt copy numbers as predictive molecular markers of decreased ex vivo doxycycline susceptibility in imported Plasmodium falciparum malaria. Malar J. 2013 Nov 14; 12:414. PMID: 24225377; PMCID: PMC3831056.
    5. Gharbi M, Flegg JA, Pradines B, Berenger A, Ndiaye M, Djimdé AA, Roper C, Hubert V, Kendjo E, Venkatesan M, Brasseur P, Gaye O, Offianan AT, Penali L, Le Bras J, Guérin PJ. Surveillance of travellers: an additional tool for tracking antimalarial drug resistance in endemic countries. PLoS One. 2013; 8(10):e77775. PMID: 24204960; PMCID: PMC3813754.
    6. Dahlström S, Aubouy A, Maïga-Ascofaré O, Faucher JF, Wakpo A, Ezinmègnon S, Massougbodji A, Houzé P, Kendjo E, Deloron P, Le Bras J, Houzé S. Plasmodium falciparum Polymorphisms associated with ex vivo drug susceptibility and clinical effectiveness of artemisinin-based combination therapies in Benin. Antimicrob Agents Chemother. 2014; 58(1):1-10. PMID: 24100489; PMCID: PMC3910716.
    7. Houzé S, Boutron I, Marmorat A, Dalichampt M, Choquet C, Poilane I, Godineau N, Le Guern AS, Thellier M, Broutier H, Fenneteau O, Millet P, Dulucq S, Hubert V, Houzé P, Tubach F, Le Bras J, Matheron S. Performance of rapid diagnostic tests for imported malaria in clinical practice: results of a national multicenter study. PLoS One. 2013; 8(9):e75486. PMID: 24098699; PMCID: PMC3787089.
    8. Woodrow CJ, Dahlström S, Cooksey R, Flegg JA, Le Nagard H, Mentré F, Murillo C, Ménard D, Nosten F, Sriprawat K, Musset L, Quashie NB, Lim P, Fairhurst RM, Nsobya SL, Sinou V, Noedl H, Pradines B, Johnson JD, Guerin PJ, Sibley CH, Le Bras J. High-throughput analysis of antimalarial susceptibility data by the WorldWide Antimalarial Resistance Network (WWARN) in vitro analysis and reporting tool. Antimicrob Agents Chemother. 2013 Jul; 57(7):3121-30. PMID: 23612201; PMCID: PMC3697366.
    9. Gharbi M, Flegg JA, Hubert V, Kendjo E, Metcalf JE, Bertaux L, Guérin PJ, Le Bras J. Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000-2011. Malar J. 2013 Jan 25; 12:35. PMID: 23351608; PMCID: PMC3583707.
    10. Gharbi M, Pillai DR, Lau R, Hubert V, Khairnar K, Existe A, Kendjo E, Dahlström S, Guérin PJ, Le Bras J. Chloroquine-resistant malaria in travelers returning from Haiti after 2010 earthquake. Emerg Infect Dis. 2012 Aug; 18(8):1346-9. PMID: 22840888; PMCID: PMC3414028.
    11. Houzé S, Hubert V, Cohen DP, Rivetz B, Le Bras J. Evaluation of the Clearview® Malaria pLDH Malaria Rapid Diagnostic Test in a non-endemic setting. Malar J. 2011 Sep 27; 10:284. PMID: 21951996; PMCID: PMC3196929.
    12. Houzé S, Hubert V, Le Pessec G, Le Bras J, Clain J. Combined deletions of pfhrp2 and pfhrp3 genes result in Plasmodium falciparum malaria false-negative rapid diagnostic test. J Clin Microbiol. 2011 Jul; 49(7):2694-6. PMID: 21543573; PMCID: PMC3147824.
    13. Seringe E, Thellier M, Fontanet A, Legros F, Bouchaud O, Ancelle T, Kendjo E, Houze S, Le Bras J, Danis M, Durand R. Severe imported Plasmodium falciparum malaria, France, 1996-2003. Emerg Infect Dis. 2011 May; 17(5):807-13. PMID: 21529388; PMCID: PMC3321778.
    14. Jambou R, Le Bras J, Randrianarivelojosia M. Pitfalls in new artemisinin-containing antimalarial drug development. Trends Parasitol. 2011 Feb; 27(2):82-90. PMID: 21030307.
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    15. Bruneel F, Tubach F, Corne P, Megarbane B, Mira JP, Peytel E, Camus C, Schortgen F, Azoulay E, Cohen Y, Georges H, Meybeck A, Hyvernat H, Trouillet JL, Frenoy E, Nicolet L, Roy C, Durand R, Le Bras J, Wolff M. Severe imported falciparum malaria: a cohort study in 400 critically ill adults. PLoS One. 2010 Oct 08; 5(10):e13236. PMID: 20949045; PMCID: PMC2951913.
    16. Maïga-Ascofaré O, Le Bras J, Mazmouz R, Renard E, Falcão S, Broussier E, Bustos D, Randrianarivelojosia M, Omar SA, Aubouy A, Lepère JF, Jean-François V, Djimdé AA, Clain J. Adaptive differentiation of Plasmodium falciparum populations inferred from single-nucleotide polymorphisms (SNPs) conferring drug resistance and from neutral SNPs. J Infect Dis. 2010 Oct 01; 202(7):1095-103. PMID: 20726766.
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    17. Le Nagard H, Vincent C, Mentré F, Le Bras J. Online analysis of in vitro resistance to antimalarial drugs through nonlinear regression. Comput Methods Programs Biomed. 2011 Oct; 104(1):10-8. PMID: 20828858.
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    18. Lim P, Wongsrichanalai C, Chim P, Khim N, Kim S, Chy S, Sem R, Nhem S, Yi P, Duong S, Bouth DM, Genton B, Beck HP, Gobert JG, Rogers WO, Coppee JY, Fandeur T, Mercereau-Puijalon O, Ringwald P, Le Bras J, Ariey F. Decreased in vitro susceptibility of Plasmodium falciparum isolates to artesunate, mefloquine, chloroquine, and quinine in Cambodia from 2001 to 2007. Antimicrob Agents Chemother. 2010 May; 54(5):2135-42. PMID: 20194689; PMCID: PMC2863643.
    19. Houzé S, Boly MD, Le Bras J, Deloron P, Faucher JF. PfHRP2 and PfLDH antigen detection for monitoring the efficacy of artemisinin-based combination therapy (ACT) in the treatment of uncomplicated falciparum malaria. Malar J. 2009 Sep 07; 8:211. PMID: 19735557; PMCID: PMC2754493.
    20. Duval L, Nerrienet E, Rousset D, Sadeuh Mba SA, Houze S, Fourment M, Le Bras J, Robert V, Ariey F. Chimpanzee malaria parasites related to Plasmodium ovale in Africa. PLoS One. 2009; 4(5):e5520. PMID: 19436742; PMCID: PMC2677663.
    21. Lim P, Alker AP, Khim N, Shah NK, Incardona S, Doung S, Yi P, Bouth DM, Bouchier C, Puijalon OM, Meshnick SR, Wongsrichanalai C, Fandeur T, Le Bras J, Ringwald P, Ariey F. Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia. Malar J. 2009 Jan 12; 8:11. PMID: 19138391; PMCID: PMC2627910.
    22. Durand R, Ariey F, Cojean S, Fontanet A, Ranaivo L, Ranarivelo LA, Vonimpaisomihanta JA, Menard D, Pietra V, Le Bras J, Modiano D, Randrianarivelojosia M. Analysis of circulating populations of Plasmodium falciparum in mild and severe malaria in two different epidemiological patterns in Madagascar. Trop Med Int Health. 2008 Nov; 13(11):1392-9. PMID: 18803610.
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    23. Nsimba B, Guiyedi V, Mabika-Mamfoumbi M, Mourou-Mbina JR, Ngoungou E, Bouyou-Akotet M, Loembet R, Durand R, Le Bras J, Kombila M. Sulphadoxine/pyrimethamine versus amodiaquine for treating uncomplicated childhood malaria in Gabon: a randomized trial to guide national policy. Malar J. 2008 Feb 12; 7:31. PMID: 18267042; PMCID: PMC2276509.
    24. Durand R, Prendki V, Cailhol J, Hubert V, Ralaimazava P, Massias L, Bouchaud O, Le Bras J. Plasmodium falciparum malaria and atovaquone-proguanil treatment failure. Emerg Infect Dis. 2008 Feb; 14(2):320-2. PMID: 18258131; PMCID: PMC2600204.
    25. D'Ortenzio E, Godineau N, Fontanet A, Houze S, Bouchaud O, Matheron S, Le Bras J. Prolonged Plasmodium falciparum infection in immigrants, Paris. Emerg Infect Dis. 2008 Feb; 14(2):323-6. PMID: 18258132; PMCID: PMC2600192.
    26. Kaddouri H, Djimdé A, Dama S, Kodio A, Tekete M, Hubert V, Koné A, Maiga H, Yattara O, Fofana B, Sidibe B, Sangaré CP, Doumbo O, Le Bras J. Baseline in vitro efficacy of ACT component drugs on Plasmodium falciparum clinical isolates from Mali. Int J Parasitol. 2008 Jun; 38(7):791-8. PMID: 18249407.
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    27. Durand R, Le Bras J, Bouchaud O. [Is chloroquine back?]. Rev Prat. 2007 Sep 30; 57(14):1513-5. PMID: 18018447.
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    28. Briand V, Bouchaud O, Tourret J, Behr C, Abgrall S, Ralaimazava P, Le Bras J, Fontanet A. Hospitalization criteria in imported falciparum malaria. J Travel Med. 2007 Sep-Oct; 14(5):306-11. PMID: 17883461.
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    29. Houzé S, Munier A, Paoletti X, Kaddouri H, Ringwald P, Le Bras J. Shelf life of predosed plates containing mefloquine, artemisinin, dihydroartemisinin, and artesunate as used for in vitro Plasmodium falciparum susceptibility assessment. J Clin Microbiol. 2007 Aug; 45(8):2734-6. PMID: 17553969; PMCID: PMC1951262.
    30. Legros F, Bouchaud O, Ancelle T, Arnaud A, Cojean S, Le Bras J, Danis M, Fontanet A, Durand R. Risk factors for imported fatal Plasmodium falciparum malaria, France, 1996-2003. Emerg Infect Dis. 2007 Jun; 13(6):883-8. PMID: 17553228.
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    31. Musset L, Le Bras J, Clain J. Parallel evolution of adaptive mutations in Plasmodium falciparum mitochondrial DNA during atovaquone-proguanil treatment. Mol Biol Evol. 2007 Aug; 24(8):1582-5. PMID: 17488741.
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    32. Noranate N, Durand R, Tall A, Marrama L, Spiegel A, Sokhna C, Pradines B, Cojean S, Guillotte M, Bischoff E, Ekala MT, Bouchier C, Fandeur T, Ariey F, Patarapotikul J, Le Bras J, Trape JF, Rogier C, Mercereau-Puijalon O. Rapid dissemination of Plasmodium falciparum drug resistance despite strictly controlled antimalarial use. PLoS One. 2007 Jan 03; 2(1):e139. PMID: 17206274; PMCID: PMC1764034.
    33. Lejeune D, Souletie I, Houzé S, Le bricon T, Le bras J, Gourmel B, Houzé P. Simultaneous determination of monodesethylchloroquine, chloroquine, cycloguanil and proguanil on dried blood spots by reverse-phase liquid chromatography. J Pharm Biomed Anal. 2007 Feb 19; 43(3):1106-15. PMID: 17097257.
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    34. Cojean S, Hubert V, Le Bras J, Durand R. Resistance to dihydroartemisinin. Emerg Infect Dis. 2006 Nov; 12(11):1798-9. PMID: 17283645; PMCID: PMC3372362.
    35. Kaddouri H, Nakache S, Houzé S, Mentré F, Le Bras J. Assessment of the drug susceptibility of Plasmodium falciparum clinical isolates from africa by using a Plasmodium lactate dehydrogenase immunodetection assay and an inhibitory maximum effect model for precise measurement of the 50-percent inhibitory concentration. Antimicrob Agents Chemother. 2006 Oct; 50(10):3343-9. PMID: 17005815; PMCID: PMC1610081.
    36. Musset L, Bouchaud O, Matheron S, Massias L, Le Bras J. Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations. Microbes Infect. 2006 Sep; 8(11):2599-604. PMID: 16962361.
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    37. Ariey F, Fandeur T, Durand R, Randrianarivelojosia M, Jambou R, Legrand E, Ekala MT, Bouchier C, Cojean S, Duchemin JB, Robert V, Le Bras J, Mercereau-Puijalon O. Invasion of Africa by a single pfcrt allele of South East Asian type. Malar J. 2006 Apr 26; 5:34. PMID: 16638153; PMCID: PMC1459864.
    38. Rabarijaona LP, Ariey F, Matra R, Cot S, Raharimalala AL, Ranaivo LH, Le Bras J, Robert V, Randrianarivelojosia M. Low autochtonous urban malaria in Antananarivo (Madagascar). Malar J. 2006 Mar 31; 5:27. PMID: 16573843; PMCID: PMC1484484.
    39. Cojean S, Noël A, Garnier D, Hubert V, Le Bras J, Durand R. Lack of association between putative transporter gene polymorphisms in Plasmodium falciparum and chloroquine resistance in imported malaria isolates from Africa. Malar J. 2006 Mar 28; 5:24. PMID: 16569231; PMCID: PMC1448192.
    40. Musset L, Pradines B, Parzy D, Durand R, Bigot P, Le Bras J. Apparent absence of atovaquone/proguanil resistance in 477 Plasmodium falciparum isolates from untreated French travellers. J Antimicrob Chemother. 2006 Jan; 57(1):110-5. PMID: 16319183.
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    41. D' Ortenzio E, Bonnet D, Leport C, Le Bras J. Falciparum malaria acquired by a French tourist in a resort area of the Dominican Republic. Euro Surveill. 2005 Oct 13; 10(10):E051013.4. PMID: 16790883.
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    42. Nsimba B, Jafari-Guemouri S, Malonga DA, Mouata AM, Kiori J, Louya F, Yocka D, Malanda M, Durand R, Le Bras J. Epidemiology of drug-resistant malaria in Republic of Congo: using molecular evidence for monitoring antimalarial drug resistance combined with assessment of antimalarial drug use. Trop Med Int Health. 2005 Oct; 10(10):1030-7. PMID: 16185238.
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    43. Fontanet AL, Houzé S, Keundjian A, Schiemann R, Ralaimazava P, Durand R, Cha O, Coulaud JP, Le Bras J, Bouchaud O. Efficacy of antimalarial chemoprophylaxis among French residents travelling to Africa. Trans R Soc Trop Med Hyg. 2005 Feb; 99(2):91-100. PMID: 15607335.
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    44. Bouchaud O, Cot M, Kony S, Durand R, Schiemann R, Ralaimazava P, Coulaud JP, Le Bras J, Deloron P. Do African immigrants living in France have long-term malarial immunity? Am J Trop Med Hyg. 2005 Jan; 72(1):21-5. PMID: 15728861.
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    45. Aubouy A, Mayombo J, Keundjian A, Bakary M, Le Bras J, Deloron P. Short report: lack of prediction of amodiaquine efficacy in treating Plasmodium falciparum malaria by in vitro tests. Am J Trop Med Hyg. 2004 Sep; 71(3):294-6. PMID: 15381809.
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    46. Nsimba B, Malonga DA, Mouata AM, Louya F, Kiori J, Malanda M, Yocka D, Oko-Ossho J, Ebata-Mongo S, Le Bras J. Efficacy of sulfadoxine/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Republic of Congo. Am J Trop Med Hyg. 2004 Feb; 70(2):133-8. PMID: 14993623.
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    47. Jafari S, Le Bras J, Bouchaud O, Durand R. Plasmodium falciparum clonal population dynamics during malaria treatment. J Infect Dis. 2004 Jan 15; 189(2):195-203. PMID: 14722883.
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    48. Kaddouri H, Jafari S, Durand R, Le Bras J. [Drug susceptibility of Plasmodium falciparum from polyclonal isolates]. J Soc Biol. 2004; 198(3):199-206. PMID: 15662936.
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    49. Aubouy A, Jafari S, Huart V, Migot-Nabias F, Mayombo J, Durand R, Bakary M, Le Bras J, Deloron P. DHFR and DHPS genotypes of Plasmodium falciparum isolates from Gabon correlate with in vitro activity of pyrimethamine and cycloguanil, but not with sulfadoxine-pyrimethamine treatment efficacy. J Antimicrob Chemother. 2003 Jul; 52(1):43-9. PMID: 12805261.
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    50. Hammadi A, Ramiandrasoa F, Sinou V, Rogier C, Fusai T, Le Bras J, Parzy D, Kunesch G, Pradines B. Cellular uptake of a catechol iron chelator and chloroquine into Plasmodium falciparum infected erythrocytes. Biochem Pharmacol. 2003 Apr 15; 65(8):1351-60. PMID: 12694876.
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    51. Le Bras J, Durand R. The mechanisms of resistance to antimalarial drugs in Plasmodium falciparum. Fundam Clin Pharmacol. 2003 Apr; 17(2):147-53. PMID: 12667224.
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    52. Jafari S, Le Bras J, Asmar M, Durand R. Molecular survey of Plasmodium falciparum resistance in south-eastern Iran. Ann Trop Med Parasitol. 2003 Mar; 97(2):119-24. PMID: 12803866.
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    53. Aubouy A, Bakary M, Keundjian A, Mbomat B, Makita JR, Migot-Nabias F, Cot M, Le Bras J, Deloron P. Combination of drug level measurement and parasite genotyping data for improved assessment of amodiaquine and sulfadoxine-pyrimethamine efficacies in treating Plasmodium falciparum malaria in Gabonese children. Antimicrob Agents Chemother. 2003 Jan; 47(1):231-7. PMID: 12499196; PMCID: PMC148969.
    54. Bruneel F, Hocqueloux L, Alberti C, Wolff M, Chevret S, Bédos JP, Durand R, Le Bras J, Régnier B, Vachon F. The clinical spectrum of severe imported falciparum malaria in the intensive care unit: report of 188 cases in adults. Am J Respir Crit Care Med. 2003 Mar 01; 167(5):684-9. PMID: 12411286.
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    55. Roussin JM, Huart V, Lepère JF, Le Bras MJ, Roussin C, Le Bras J. [Rapid detection of malaria and P. falciparum chemoresistant genotypes in Mayotte, 2001]. Presse Med. 2002 Sep 07; 31(28):1312. PMID: 12355993.
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    56. Durand R, Huart V, Jafari S, Le Bras J. Rapid detection of a molecular marker for chloroquine-resistant falciparum malaria. Antimicrob Agents Chemother. 2002 Aug; 46(8):2684-6. PMID: 12121957; PMCID: PMC127343.
    57. Casalino E, Le Bras J, Chaussin F, Fichelle A, Bouvet E. Predictive factors of malaria in travelers to areas where malaria is endemic. Arch Intern Med. 2002 Jul 22; 162(14):1625-30. PMID: 12123407.
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    58. Jafari S, Durand R, Lusina D, Le Bras J. Molecular characterisation of airport malaria: four cases in France during summer 1999. Parasite. 2002 Jun; 9(2):187-91. PMID: 12116866.
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    59. Pradines B, Ramiandrasoa F, Rolain JM, Rogier C, Mosnier J, Daries W, Fusai T, Kunesch G, Le Bras J, Parzy D. In vitro potentiation of antibiotic activities by a catecholate iron chelator against chloroquine-resistant Plasmodium falciparum. Antimicrob Agents Chemother. 2002 Jan; 46(1):225-8. PMID: 11751139; PMCID: PMC127010.
    60. Durand R, Jafari S, Bouchaud O, Ralaimazava P, Keundjian A, Le Bras J. Plasmodium falciparum: pfcrt and DHFR mutations are associated with failure of chloroquine plus proguanil prophylaxis in travelers. J Infect Dis. 2001 Dec 15; 184(12):1633-4. PMID: 11740746.
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    61. Durand R, Jafari S, Vauzelle J, Delabre JF, Jesic Z, Le Bras J. Analysis of pfcrt point mutations and chloroquine susceptibility in isolates of Plasmodium falciparum. Mol Biochem Parasitol. 2001 Apr 25; 114(1):95-102. PMID: 11356518.
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    62. Durand R, Eslahpazire J, Jafari S, Delabre JF, Marmorat-Khuong A, di Piazza JP, Le Bras J. Use of molecular beacons to detect an antifolate resistance-associated mutation in Plasmodium falciparum. Antimicrob Agents Chemother. 2000 Dec; 44(12):3461-4. PMID: 11083660; PMCID: PMC90225.
    63. Le Bras J. In vitro susceptibility of African Plasmodium falciparum isolates to dihydroartemisinin and the risk factors for resistance to qinghaosu. Med Trop (Mars). 1998; 58(3 Suppl):18-21. PMID: 10212892.
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