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Professor John Edwin Hyde

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Müller IB, Hyde JE. Folate metabolism in human malaria parasites--75 years on. Mol Biochem Parasitol. 2013 Mar; 188(1):63-77. PMID: 23500968.
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    2. Southworth PM, Hyde JE, Sims PF. A mass spectrometric strategy for absolute quantification of Plasmodium falciparum proteins of low abundance. Malar J. 2011 Oct 25; 10:315. PMID: 22027174; PMCID: PMC3219587.
    3. Read M, Müller IB, Mitchell SL, Sims PF, Hyde JE. Dynamic subcellular localization of isoforms of the folate pathway enzyme serine hydroxymethyltransferase (SHMT) through the erythrocytic cycle of Plasmodium falciparum. Malar J. 2010 Dec 03; 9:351. PMID: 21129192; PMCID: PMC3014972.
    4. Müller IB, Hyde JE. Antimalarial drugs: modes of action and mechanisms of parasite resistance. Future Microbiol. 2010 Dec; 5(12):1857-73. PMID: 21155666.
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    5. O'Cualain RD, Hyde JE, Sims PF. A protein-centric approach for the identification of folate enzymes from the malarial parasite, Plasmodium falciparum, using OFFGEL™ solution-based isoelectric focussing and mass spectrometry. Malar J. 2010 Oct 18; 9:286. PMID: 20955557; PMCID: PMC2967559.
    6. Wang P, Wang Q, Yang Y, Coward JK, Nzila A, Sims PF, Hyde JE. Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition. Mol Biochem Parasitol. 2010 Jul; 172(1):41-51. PMID: 20350571; PMCID: PMC2877875.
    7. Müller IB, Hyde JE, Wrenger C. Vitamin B metabolism in Plasmodium falciparum as a source of drug targets. Trends Parasitol. 2010 Jan; 26(1):35-43. PMID: 19939733.
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    8. Hyde JE. Mapping the origins and spread of antifolate-resistant malaria parasites. Future Microbiol. 2009 Oct; 4(8):953-8. PMID: 19824787.
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    9. Pribat A, Jeanguenin L, Lara-Núñez A, Ziemak MJ, Hyde JE, de Crécy-Lagard V, Hanson AD. 6-pyruvoyltetrahydropterin synthase paralogs replace the folate synthesis enzyme dihydroneopterin aldolase in diverse bacteria. J Bacteriol. 2009 Jul; 191(13):4158-65. PMID: 19395485; PMCID: PMC2698474.
    10. Hyde JE, Dittrich S, Wang P, Sims PF, de Crécy-Lagard V, Hanson AD. Plasmodium falciparum: a paradigm for alternative folate biosynthesis in diverse microorganisms? Trends Parasitol. 2008 Nov; 24(11):502-8. PMID: 18805734; PMCID: PMC2720532.
    11. Hyde JE. Fine targeting of purine salvage in Cryptosporidium parasites. Trends Parasitol. 2008 Aug; 24(8):336-9. PMID: 18586557.
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    12. Hyde JE. Antifolate resistance in Africa and the 164-dollar question. Trans R Soc Trop Med Hyg. 2008 Apr; 102(4):301-3. PMID: 18316104; PMCID: PMC2720017.
    13. Dittrich S, Mitchell SL, Blagborough AM, Wang Q, Wang P, Sims PF, Hyde JE. An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites. Mol Microbiol. 2008 Feb; 67(3):609-18. PMID: 18093090; PMCID: PMC2229834.
    14. Hyde JE. Drug-resistant malaria - an insight. FEBS J. 2007 Sep; 274(18):4688-98. PMID: 17824955; PMCID: PMC2720519.
    15. Nirmalan N, Flett F, Skinner T, Hyde JE, Sims PF. Microscale solution isoelectric focusing as an effective strategy enabling containment of hemeoglobin-derived products for high-resolution gel-based analysis of the Plasmodium falciparum proteome. J Proteome Res. 2007 Sep; 6(9):3780-7. PMID: 17696383; PMCID: PMC2632839.
    16. Wang P, Wang Q, Sims PF, Hyde JE. Characterisation of exogenous folate transport in Plasmodium falciparum. Mol Biochem Parasitol. 2007 Jul; 154(1):40-51. PMID: 17509698; PMCID: PMC1906846.
    17. Hyde JE. Targeting purine and pyrimidine metabolism in human apicomplexan parasites. Curr Drug Targets. 2007 Jan; 8(1):31-47. PMID: 17266529; PMCID: PMC2720675.
    18. Sims PF, Hyde JE. Proteomics of the human malaria parasite Plasmodium falciparum. Expert Rev Proteomics. 2006 Feb; 3(1):87-95. PMID: 16445353; PMCID: PMC2721975.
    19. Wang Q, Hauser V, Read M, Wang P, Hanson AD, Sims PF, Hyde JE. Functional identification of orthologous genes encoding pterin recycling activity in Plasmodium falciparum and Toxoplasma gondii. Mol Biochem Parasitol. 2006 Mar; 146(1):109-12. PMID: 16337017; PMCID: PMC2719813.
    20. Hyde JE. Drug-resistant malaria. Trends Parasitol. 2005 Nov; 21(11):494-8. PMID: 16140578; PMCID: PMC2722032.
    21. Salcedo E, Sims PF, Hyde JE. A glycine-cleavage complex as part of the folate one-carbon metabolism of Plasmodium falciparum. Trends Parasitol. 2005 Sep; 21(9):406-11. PMID: 16039160; PMCID: PMC2719866.
    22. Nzila A, Ward SA, Marsh K, Sims PF, Hyde JE. Comparative folate metabolism in humans and malaria parasites (part II): activities as yet untargeted or specific to Plasmodium. Trends Parasitol. 2005 Jul; 21(7):334-9. PMID: 15936248; PMCID: PMC2720531.
    23. Nzila A, Ward SA, Marsh K, Sims PF, Hyde JE. Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy. Trends Parasitol. 2005 Jun; 21(6):292-8. PMID: 15922251; PMCID: PMC2720520.
    24. Hyde JE. Exploring the folate pathway in Plasmodium falciparum. Acta Trop. 2005 Jun; 94(3):191-206. PMID: 15845349; PMCID: PMC2720607.
    25. Nirmalan N, Sims PF, Hyde JE. Translational up-regulation of antifolate drug targets in the human malaria parasite Plasmodium falciparum upon challenge with inhibitors. Mol Biochem Parasitol. 2004 Jul; 136(1):63-70. PMID: 15138068.
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    26. Nirmalan N, Sims PF, Hyde JE. Quantitative proteomics of the human malaria parasite Plasmodium falciparum and its application to studies of development and inhibition. Mol Microbiol. 2004 May; 52(4):1187-99. PMID: 15130134.
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    27. Wang P, Nirmalan N, Wang Q, Sims PF, Hyde JE. Genetic and metabolic analysis of folate salvage in the human malaria parasite Plasmodium falciparum. Mol Biochem Parasitol. 2004 May; 135(1):77-87. PMID: 15287589.
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    28. Wang P, Wang Q, Aspinall TV, Sims PF, Hyde JE. Transfection studies to explore essential folate metabolism and antifolate drug synergy in the human malaria parasite Plasmodium falciparum. Mol Microbiol. 2004 Mar; 51(5):1425-38. PMID: 14982635.
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    29. Sardarian A, Douglas KT, Read M, Sims PF, Hyde JE, Chitnumsub P, Sirawaraporn R, Sirawaraporn W. Pyrimethamine analogs as strong inhibitors of double and quadruple mutants of dihydrofolate reductase in human malaria parasites. Org Biomol Chem. 2003 Mar 21; 1(6):960-4. PMID: 12929634.
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    30. Aspinall TV, Guy EC, Roberts KE, Joynson DH, Hyde JE, Sims PF. Molecular evidence for multiple Toxoplasma gondii infections in individual patients in England and Wales: public health implications. Int J Parasitol. 2003 Jan; 33(1):97-103. PMID: 12547351.
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    31. Nirmalan N, Wang P, Sims PF, Hyde JE. Transcriptional analysis of genes encoding enzymes of the folate pathway in the human malaria parasite Plasmodium falciparum. Mol Microbiol. 2002 Oct; 46(1):179-90. PMID: 12366841.
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    32. Wang P, Wang Q, Sims PF, Hyde JE. Rapid positive selection of stable integrants following transfection of Plasmodium falciparum. Mol Biochem Parasitol. 2002 Aug 07; 123(1):1-10. PMID: 12165384.
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    33. Aspinall TV, Marlee D, Hyde JE, Sims PF. Prevalence of Toxoplasma gondii in commercial meat products as monitored by polymerase chain reaction--food for thought? Int J Parasitol. 2002 Aug; 32(9):1193-9. PMID: 12117502.
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    34. Aspinall TV, Joynson DH, Guy E, Hyde JE, Sims PF. The molecular basis of sulfonamide resistance in Toxoplasma gondii and implications for the clinical management of toxoplasmosis. J Infect Dis. 2002 Jun 01; 185(11):1637-43. PMID: 12023770.
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    35. Hyde JE. Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs. Microbes Infect. 2002 Feb; 4(2):165-74. PMID: 11880048.
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    36. Sibley CH, Hyde JE, Sims PF, Plowe CV, Kublin JG, Mberu EK, Cowman AF, Winstanley PA, Watkins WM, Nzila AM. Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next? Trends Parasitol. 2001 Dec; 17(12):582-8. PMID: 11756042.
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    37. Hyde JE, Sims PF. Sulfa-drug resistance in Plasmodium falciparum. Trends Parasitol. 2001 Jun; 17(6):265-6. PMID: 11426433.
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    38. Salcedo E, Cortese JF, Plowe CV, Sims PF, Hyde JE. A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria. Mol Biochem Parasitol. 2001 Feb; 112(2):239-52. PMID: 11223131.
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    39. Lee CS, Salcedo E, Wang Q, Wang P, Sims PF, Hyde JE. Characterization of three genes encoding enzymes of the folate biosynthetic pathway in Plasmodium falciparum. Parasitology. 2001 Jan; 122 Pt 1:1-13. PMID: 11197757.
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    40. Wang P, Brobey RK, Horii T, Sims PF, Hyde JE. Utilization of exogenous folate in the human malaria parasite Plasmodium falciparum and its critical role in antifolate drug synergy. Mol Microbiol. 1999 Jun; 32(6):1254-62. PMID: 10383765.
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    41. Sims P, Wang P, Hyde JE. Selection and synergy in Plasmodium falciparum. Parasitol Today. 1999 Apr; 15(4):132-4. PMID: 10322332.
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    42. Triglia T, Wang P, Sims PF, Hyde JE, Cowman AF. Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria. EMBO J. 1998 Jul 15; 17(14):3807-15. PMID: 9669998; PMCID: PMC1170716.
    43. McKie JH, Douglas KT, Chan C, Roser SA, Yates R, Read M, Hyde JE, Dascombe MJ, Yuthavong Y, Sirawaraporn W. Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria. J Med Chem. 1998 Apr 23; 41(9):1367-70. PMID: 9554869.
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    44. Sims P, Wang P, Hyde JE. On ;the efficacy of antifolate antimalarial combinations in Africa'. Parasitol Today. 1998 Apr; 14(4):136-7. PMID: 17040729.
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    45. Shaio MF, Wang P, Lee CS, Sims PF, Hyde JE. Development and comparison of quantitative assays for the dihydropteroate synthetase codon 540 mutation associated with sulfadoxine resistance in Plasmodium falciparum. Parasitology. 1998 Mar; 116 ( Pt 3):203-10. PMID: 9550212.
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    46. Wang P, Lee CS, Bayoumi R, Djimde A, Doumbo O, Swedberg G, Dao LD, Mshinda H, Tanner M, Watkins WM, Sims PF, Hyde JE. Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins. Mol Biochem Parasitol. 1997 Nov; 89(2):161-77. PMID: 9364963.
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    47. Wang P, Sims PF, Hyde JE. A modified in vitro sulfadoxine susceptibility assay for Plasmodium falciparum suitable for investigating Fansidar resistance. Parasitology. 1997 Sep; 115 ( Pt 3):223-30. PMID: 9300459.
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    48. Read M, Hyde JE. On malaria and the cell cycle. Parasitol Today. 1997 Jun; 13(6):241; author reply 241-2. PMID: 15275079.
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    49. Pashley TV, Volpe F, Pudney M, Hyde JE, Sims PF, Delves CJ. Isolation and molecular characterization of the bifunctional hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase gene from Toxoplasma gondii. Mol Biochem Parasitol. 1997 May; 86(1):37-47. PMID: 9178266.
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    50. Wang P, Read M, Sims PF, Hyde JE. Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization. Mol Microbiol. 1997 Mar; 23(5):979-86. PMID: 9076734.
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    51. Hyde JE. Transformation of malaria parasites: the barriers come down. Trends Microbiol. 1996 Feb; 4(2):43-5. PMID: 8820562.
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    52. Wang P, Brooks DR, Sims PF, Hyde JE. A mutation-specific PCR system to detect sequence variation in the dihydropteroate synthetase gene of Plasmodium falciparum. Mol Biochem Parasitol. 1995 Apr; 71(1):115-25. PMID: 7630375.
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    53. Brooks DR, Wang P, Read M, Watkins WM, Sims PF, Hyde JE. Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. Eur J Biochem. 1994 Sep 01; 224(2):397-405. PMID: 7925353.
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    54. Read M, Hicks KE, Sims PF, Hyde JE. Molecular characterisation of the enolase gene from the human malaria parasite Plasmodium falciparum. Evidence for ancestry within a photosynthetic lineage. Eur J Biochem. 1994 Mar 01; 220(2):513-20. PMID: 8125109.
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    55. Hyde JE, Sims PF, Read M. Green roots of malaria. Parasitol Today. 1994 Jan; 10(1):25. PMID: 15275562.
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    56. Read M, Sherwin T, Holloway SP, Gull K, Hyde JE. Microtubular organization visualized by immunofluorescence microscopy during erythrocytic schizogony in Plasmodium falciparum and investigation of post-translational modifications of parasite tubulin. Parasitology. 1993 Apr; 106 ( Pt 3):223-32. PMID: 8488059.
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    57. McAndrew MB, Read M, Sims PF, Hyde JE. Characterisation of the gene encoding an unusually divergent TATA-binding protein (TBP) from the extremely A+T-rich human malaria parasite Plasmodium falciparum. Gene. 1993 Feb 28; 124(2):165-71. PMID: 8444340.
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    58. Hyde JE, Holloway SP. Isolation of parasite genes using synthetic oligonucleotides. Methods Mol Biol. 1993; 21:303-18. PMID: 8220724.
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    59. Read M, Hyde JE. Simple in vitro cultivation of the malaria parasite Plasmodium falciparum (erythrocytic stages) suitable for large-scale preparations. Methods Mol Biol. 1993; 21:43-55. PMID: 8220733.
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    60. Hyde JE, Read M. The extraction and purification of DNA and RNA from in vitro cultures of the malaria parasite Plasmodium falciparum. Methods Mol Biol. 1993; 21:133-43. PMID: 8220711.
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    61. Hyde JE, Sims PF, Read M, McAndrew MB. Deviant TATA-box binding protein. Nature. 1992 Dec 10; 360(6404):541. PMID: 1461276.
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    62. Hall SJ, Sims PF, Hyde JE. Functional expression of the dihydrofolate reductase and thymidylate synthetase activities of the human malaria parasite Plasmodium falciparum in Escherichia coli. Mol Biochem Parasitol. 1991 Apr; 45(2):317-30. PMID: 2038362.
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    63. Hicks KE, Read M, Holloway SP, Sims PF, Hyde JE. Glycolytic pathway of the human malaria parasite Plasmodium falciparum: primary sequence analysis of the gene encoding 3-phosphoglycerate kinase and chromosomal mapping studies. Gene. 1991 Apr; 100:123-9. PMID: 2055463.
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    64. Delves CJ, Alano P, Ridley RG, Goman M, Holloway SP, Hyde JE, Scaife JG. Expression of alpha and beta tubulin genes during the asexual and sexual blood stages of Plasmodium falciparum. Mol Biochem Parasitol. 1990 Dec; 43(2):271-8. PMID: 2090948.
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    65. Holloway SP, Gerousis M, Delves CJ, Sims PF, Scaife JG, Hyde JE. The tubulin genes of the human malaria parasite Plasmodium falciparum, their chromosomal location and sequence analysis of the alpha-tubulin II gene. Mol Biochem Parasitol. 1990 Dec; 43(2):257-70. PMID: 2090947.
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    66. Hyde JE. The dihydrofolate reductase-thymidylate synthetase gene in the drug resistance of malaria parasites. Pharmacol Ther. 1990; 48(1):45-59. PMID: 2274577.
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    67. Holloway SP, Sims PF, Delves CJ, Scaife JG, Hyde JE. Isolation of alpha-tubulin genes from the human malaria parasite, Plasmodium falciparum: sequence analysis of alpha-tubulin. Mol Microbiol. 1989 Nov; 3(11):1501-10. PMID: 2693901.
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    68. Delves CJ, Ridley RG, Goman M, Holloway SP, Hyde JE, Scaife JG. Cloning of a beta-tubulin gene from Plasmodium falciparum. Mol Microbiol. 1989 Nov; 3(11):1511-9. PMID: 2693902.
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    69. Hyde JE. Point mutations and pyrimethamine resistance in Plasmodium falciparum. Parasitol Today. 1989 Aug; 5(8):252-5. PMID: 15463226.
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    70. Snewin VA, England SM, Sims PF, Hyde JE. Characterisation of the dihydrofolate reductase-thymidylate synthetase gene from human malaria parasites highly resistant to pyrimethamine. Gene. 1989 Mar 15; 76(1):41-52. PMID: 2663650.
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    71. Hyde JE, Kelly SL, Holloway SP, Snewin VA, Sims PF. A general approach to isolating Plasmodium falciparum genes using non-redundant oligonucleotides inferred from protein sequences of other organisms. Mol Biochem Parasitol. 1989 Jan 15; 32(2-3):247-61. PMID: 2648142.
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    72. Read M, Hyde JE. The use of human plasmas and plasma-depleted blood fractions in the in vitro cultivation of the malaria parasite Plasmodium falciparum. Trop Med Parasitol. 1988 Mar; 39(1):43-4. PMID: 3291075.
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    73. Hyde JE, Sims PF. Anomalous dinucleotide frequencies in both coding and non-coding regions from the genome of the human malaria parasite Plasmodium falciparum. Gene. 1987; 61(2):177-87. PMID: 3327756.
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    74. Scaife J, Bone N, Goman M, Hall R, Hope IA, Hyde JE, Langsley G, Mackay M, Oquendo P, Simmons D. Antigens of Plasmodium falciparum blood stages with clinical interest cloned and expressed in E. coli. Parasitology. 1986; 92 Suppl:S119-37. PMID: 2872646.
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    75. Mackay M, Goman M, Bone N, Hyde JE, Scaife J, Certa U, Stunnenberg H, Bujard H. Polymorphism of the precursor for the major surface antigens of Plasmodium falciparum merozoites: studies at the genetic level. EMBO J. 1985 Dec 30; 4(13B):3823-9. PMID: 3004972; PMCID: PMC554737.
    76. Simmons DL, Hyde JE, Mackay M, Goman M, Scaife J. Cloning studies on the gene coding for L-(+)-lactate dehydrogenase of Plasmodium falciparum. Mol Biochem Parasitol. 1985 May; 15(2):231-43. PMID: 3892292.
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    77. Hope IA, Mackay M, Hyde JE, Goman M, Scaife J. The gene for an exported antigen of the malaria parasite Plasmodium falciparum cloned and expressed in Escherichia coli. Nucleic Acids Res. 1985 Jan 25; 13(2):369-79. PMID: 2582354; PMCID: PMC341001.
    78. Hall R, Hyde JE, Goman M, Simmons DL, Hope IA, Mackay M, Scaife J, Merkli B, Richle R, Stocker J. Major surface antigen gene of a human malaria parasite cloned and expressed in bacteria. Nature. 1984 Sep 27-Oct 3; 311(5984):379-82. PMID: 6090934.
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    79. Hall R, Osland A, Hyde JE, Simmons DL, Hope IA, Scaife JG. Processing, polymorphism, and biological significance of P190, a major surface antigen of the erythrocytic forms of Plasmodium falciparum. Mol Biochem Parasitol. 1984 Apr; 11:61-80. PMID: 6205267.
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    80. Hyde JE, Goman M, Hall R, Osland A, Hope IA, Langsley G, Zolg JW, Scaife JG. Characterisation and translation studies of messenger RNA from the human malaria parasite Plasmodium falciparum and construction of a cDNA library. Mol Biochem Parasitol. 1984 Mar; 10(3):269-85. PMID: 6203036.
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    81. Langsley G, Hyde JE, Goman M, Scaife JG. Cloning and characterisation of the rRNA genes from the human malaria parasite Plasmodium falciparum. Nucleic Acids Res. 1983 Dec 20; 11(24):8703-17. PMID: 6324096; PMCID: PMC326618.
    82. Goman M, Langsley G, Hyde JE, Yankovsky NK, Zolg JW, Scaife JG. The establishment of genomic DNA libraries for the human malaria parasite Plasmodium falciparum and identification of individual clones by hybridisation. Mol Biochem Parasitol. 1982 Jun; 5(6):391-400. PMID: 6213858.
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    83. Hyde JE, Zolg JW, Scaife JG. Isolation and characterisation of ribosomal RNA from the human malaria parasite Plasmodium falciparum. Mol Biochem Parasitol. 1981 Dec 31; 4(5-6):283-90. PMID: 7038480.
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