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Dr Norma Windsor Andrews

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Miller H, Castro-Gomes T, Corrotte M, Tam C, Maugel TK, Andrews NW, Song W. Lipid raft-dependent plasma membrane repair interferes with the activation of B lymphocytes. J Cell Biol. 2015 Dec 21; 211(6):1193-205. PMID: 26694840; PMCID: PMC4687878.
    2. Andrews NW, Almeida PE, Corrotte M. Damage control: cellular mechanisms of plasma membrane repair. Trends Cell Biol. 2014 Dec; 24(12):734-42. PMID: 25150593; PMCID: PMC4252702.
    3. Hissa B, Pontes B, Roma PM, Alves AP, Rocha CD, Valverde TM, Aguiar PH, Almeida FP, Guimarães AJ, Guatimosim C, Silva AM, Fernandes MC, Andrews NW, Viana NB, Mesquita ON, Agero U, Andrade LO. Membrane cholesterol removal changes mechanical properties of cells and induces secretion of a specific pool of lysosomes. PLoS One. 2013; 8(12):e82988. PMID: 24376622; PMCID: PMC3869752.
    4. Tam C, Flannery AR, Andrews N. Live imaging assay for assessing the roles of Ca2+ and sphingomyelinase in the repair of pore-forming toxin wounds. J Vis Exp. 2013 Aug 25; (78):e50531. PMID: 23995606; PMCID: PMC3856312.
    5. Fernandes MC, Andrews NW. Host cell invasion by Trypanosoma cruzi: a unique strategy that promotes persistence. FEMS Microbiol Rev. 2012 May; 36(3):734-47. PMID: 22339763; PMCID: PMC3319478.
    6. Fernandes MC, Andrade LR, Andrews NW, Mortara RA. Trypanosoma cruzi trypomastigotes induce cytoskeleton modifications during HeLa cell invasion. Mem Inst Oswaldo Cruz. 2011 Dec; 106(8):1014-6. PMID: 22241126.
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    7. Fernandes MC, Cortez M, Flannery AR, Tam C, Mortara RA, Andrews NW. Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasion. J Exp Med. 2011 May 09; 208(5):909-21. PMID: 21536739; PMCID: PMC3092353.
    8. Flannery AR, Czibener C, Andrews NW. Palmitoylation-dependent association with CD63 targets the Ca2+ sensor synaptotagmin VII to lysosomes. J Cell Biol. 2010 Nov 01; 191(3):599-613. PMID: 21041449; PMCID: PMC3003310.
    9. Albertti LA, Macedo AM, Chiari E, Andrews NW, Andrade LO. Role of host lysosomal associated membrane protein (LAMP) in Trypanosoma cruzi invasion and intracellular development. Microbes Infect. 2010 Sep; 12(10):784-9. PMID: 20561595; PMCID: PMC2934878.
    10. Tam C, Idone V, Devlin C, Fernandes MC, Flannery A, He X, Schuchman E, Tabas I, Andrews NW. Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair. J Cell Biol. 2010 Jun 14; 189(6):1027-38. PMID: 20530211; PMCID: PMC2886342.
    11. Colvin RA, Means TK, Diefenbach TJ, Moita LF, Friday RP, Sever S, Campanella GS, Abrazinski T, Manice LA, Moita C, Andrews NW, Wu D, Hacohen N, Luster AD. Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat Immunol. 2010 Jun; 11(6):495-502. PMID: 20473299; PMCID: PMC2951881.
    12. Jacques I, Andrews NW, Huynh C. Functional characterization of LIT1, the Leishmania amazonensis ferrous iron transporter. Mol Biochem Parasitol. 2010 Mar; 170(1):28-36. PMID: 20025906; PMCID: PMC2815141.
    13. da Silva CV, Kawashita SY, Probst CM, Dallagiovanna B, Cruz MC, da Silva EA, Souto-Padrón TC, Krieger MA, Goldenberg S, Briones MR, Andrews NW, Mortara RA. Characterization of a 21kDa protein from Trypanosoma cruzi associated with mammalian cell invasion. Microbes Infect. 2009 Apr; 11(5):563-70. PMID: 19344784.
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    14. Becker SM, Delamarre L, Mellman I, Andrews NW. Differential role of the Ca(2+) sensor synaptotagmin VII in macrophages and dendritic cells. Immunobiology. 2009; 214(7):495-505. PMID: 19157638; PMCID: PMC4737586.
    15. Wilson J, Huynh C, Kennedy KA, Ward DM, Kaplan J, Aderem A, Andrews NW. Control of parasitophorous vacuole expansion by LYST/Beige restricts the intracellular growth of Leishmania amazonensis. PLoS Pathog. 2008 Oct; 4(10):e1000179. PMID: 18927622; PMCID: PMC2562527.
    16. Idone V, Tam C, Andrews NW. Two-way traffic on the road to plasma membrane repair. Trends Cell Biol. 2008 Nov; 18(11):552-9. PMID: 18848451; PMCID: PMC2593466.
    17. Zhao H, Ito Y, Chappel J, Andrews NW, Teitelbaum SL, Ross FP. Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion. Dev Cell. 2008 Jun; 14(6):914-25. PMID: 18539119; PMCID: PMC2480494.
    18. Idone V, Tam C, Goss JW, Toomre D, Pypaert M, Andrews NW. Repair of injured plasma membrane by rapid Ca2+-dependent endocytosis. J Cell Biol. 2008 Mar 10; 180(5):905-14. PMID: 18316410; PMCID: PMC2265401.
    19. Li Y, Wang P, Xu J, Gorelick F, Yamazaki H, Andrews N, Desir GV. Regulation of insulin secretion and GLUT4 trafficking by the calcium sensor synaptotagmin VII. Biochem Biophys Res Commun. 2007 Oct 26; 362(3):658-64. PMID: 17720139; PMCID: PMC2194288.
    20. Fowler KT, Andrews NW, Huleatt JW. Expression and function of synaptotagmin VII in CTLs. J Immunol. 2007 Feb 01; 178(3):1498-504. PMID: 17237398; PMCID: PMC2203615.
    21. Huynh C, Sacks DL, Andrews NW. A Leishmania amazonensis ZIP family iron transporter is essential for parasite replication within macrophage phagolysosomes. J Exp Med. 2006 Oct 02; 203(10):2363-75. PMID: 17000865; PMCID: PMC2118100.
    22. Czibener C, Sherer NM, Becker SM, Pypaert M, Hui E, Chapman ER, Mothes W, Andrews NW. Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes. J Cell Biol. 2006 Sep 25; 174(7):997-1007. PMID: 16982801; PMCID: PMC2064391.
    23. Arantes RM, Andrews NW. A role for synaptotagmin VII-regulated exocytosis of lysosomes in neurite outgrowth from primary sympathetic neurons. J Neurosci. 2006 Apr 26; 26(17):4630-7. PMID: 16641243.
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    24. Andrade LO, Andrews NW. The Trypanosoma cruzi-host-cell interplay: location, invasion, retention. Nat Rev Microbiol. 2005 Oct; 3(10):819-23. PMID: 16175174.
      View in: PubMed
    25. Andrews NW, Chakrabarti S. There's more to life than neurotransmission: the regulation of exocytosis by synaptotagmin VII. Trends Cell Biol. 2005 Nov; 15(11):626-31. PMID: 16168654.
      View in: PubMed
    26. Andrews NW. Membrane repair and immunological danger. EMBO Rep. 2005 Sep; 6(9):826-30. PMID: 16138093; PMCID: PMC1369169.
    27. Huynh C, Andrews NW. The small chemical vacuolin-1 alters the morphology of lysosomes without inhibiting Ca2+-regulated exocytosis. EMBO Rep. 2005 Sep; 6(9):843-7. PMID: 16113649; PMCID: PMC1369166.
    28. Andrews NW. Membrane resealing: synaptotagmin VII keeps running the show. Sci STKE. 2005 May 03; 2005(282):pe19. PMID: 15870423.
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    29. Chakrabarti S, Andrade LO, Andrews NW. Trypanosoma cruzi invades synaptotagmin VII-deficient cells by a PI-3 kinase independent pathway. Mol Biochem Parasitol. 2005 May; 141(1):125-8. PMID: 15811535.
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    30. Huynh C, Roth D, Ward DM, Kaplan J, Andrews NW. Defective lysosomal exocytosis and plasma membrane repair in Chediak-Higashi/beige cells. Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16795-800. PMID: 15557559; PMCID: PMC534728.
    31. Andrade LO, Andrews NW. Lysosomal fusion is essential for the retention of Trypanosoma cruzi inside host cells. J Exp Med. 2004 Nov 01; 200(9):1135-43. PMID: 15520245; PMCID: PMC2211867.
    32. Jaiswal JK, Chakrabarti S, Andrews NW, Simon SM. Synaptotagmin VII restricts fusion pore expansion during lysosomal exocytosis. PLoS Biol. 2004 Aug; 2(8):E233. PMID: 15226824; PMCID: PMC439782.
    33. Roy D, Liston DR, Idone VJ, Di A, Nelson DJ, Pujol C, Bliska JB, Chakrabarti S, Andrews NW. A process for controlling intracellular bacterial infections induced by membrane injury. Science. 2004 Jun 04; 304(5676):1515-8. PMID: 15178804.
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    34. Rao SK, Huynh C, Proux-Gillardeaux V, Galli T, Andrews NW. Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis. J Biol Chem. 2004 May 07; 279(19):20471-9. PMID: 14993220.
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    35. Chakrabarti S, Kobayashi KS, Flavell RA, Marks CB, Miyake K, Liston DR, Fowler KT, Gorelick FS, Andrews NW. Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice. J Cell Biol. 2003 Aug 18; 162(4):543-9. PMID: 12925704; PMCID: PMC2173791.
    36. Jaiswal JK, Andrews NW, Simon SM. Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells. J Cell Biol. 2002 Nov 25; 159(4):625-35. PMID: 12438417; PMCID: PMC2173094.
    37. Tan H, Andrews NW. Don't bother to knock--the cell invasion strategy of Trypanosoma cruzi. Trends Parasitol. 2002 Oct; 18(10):427-8. PMID: 12377585.
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    38. Morehead J, Coppens I, Andrews NW. Opsonization modulates Rac-1 activation during cell entry by Leishmania amazonensis. Infect Immun. 2002 Aug; 70(8):4571-80. PMID: 12117970; PMCID: PMC128177.
    39. Andrews NW. Lysosomes and the plasma membrane: trypanosomes reveal a secret relationship. J Cell Biol. 2002 Aug 05; 158(3):389-94. PMID: 12147679; PMCID: PMC2173812.
    40. Lopez M, Huynh C, Andrade LO, Pypaert M, Andrews NW. Role for sialic acid in the formation of tight lysosome-derived vacuoles during Trypanosoma cruzi invasion. Mol Biochem Parasitol. 2002 Jan; 119(1):141-5. PMID: 11755197.
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    41. Reddy A, Caler EV, Andrews NW. Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes. Cell. 2001 Jul 27; 106(2):157-69. PMID: 11511344.
      View in: PubMed
    42. Caler EV, Chakrabarti S, Fowler KT, Rao S, Andrews NW. The Exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi. J Exp Med. 2001 May 07; 193(9):1097-104. PMID: 11342594; PMCID: PMC2193425.
    43. Kima PE, Burleigh B, Andrews NW. Surface-targeted lysosomal membrane glycoprotein-1 (Lamp-1) enhances lysosome exocytosis and cell invasion by Trypanosoma cruzi. Cell Microbiol. 2000 Dec; 2(6):477-86. PMID: 11207602.
      View in: PubMed
    44. Caler EV, Morty RE, Burleigh BA, Andrews NW. Dual role of signaling pathways leading to Ca(2+) and cyclic AMP elevation in host cell invasion by Trypanosoma cruzi. Infect Immun. 2000 Dec; 68(12):6602-10. PMID: 11083771; PMCID: PMC97756.
    45. Andrews NW. Regulated secretion of conventional lysosomes. Trends Cell Biol. 2000 Aug; 10(8):316-21. PMID: 10884683.
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    46. Martinez I, Chakrabarti S, Hellevik T, Morehead J, Fowler K, Andrews NW. Synaptotagmin VII regulates Ca(2+)-dependent exocytosis of lysosomes in fibroblasts. J Cell Biol. 2000 Mar 20; 148(6):1141-49. PMID: 10725327; PMCID: PMC2174306.
    47. Sibley LD, Andrews NW. Cell invasion by un-palatable parasites. Traffic. 2000 Feb; 1(2):100-6. PMID: 11208090.
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    48. Rodríguez A, Martinez I, Chung A, Berlot CH, Andrews NW. cAMP regulates Ca2+-dependent exocytosis of lysosomes and lysosome-mediated cell invasion by trypanosomes. J Biol Chem. 1999 Jun 11; 274(24):16754-9. PMID: 10358016.
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    49. Caler EV, Vaena de Avalos S, Haynes PA, Andrews NW, Burleigh BA. Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruzi. EMBO J. 1998 Sep 01; 17(17):4975-86. PMID: 9724634; PMCID: PMC1170826.
    50. Burleigh BA, Andrews NW. Signaling and host cell invasion by Trypanosoma cruzi. Curr Opin Microbiol. 1998 Aug; 1(4):461-5. PMID: 10066513.
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    51. Leite MF, Moyer MS, Andrews NW. Expression of the mammalian calcium signaling response to Trypanosoma cruzi in Xenopus laevis oocytes. Mol Biochem Parasitol. 1998 Apr 01; 92(1):1-13. PMID: 9574905.
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    52. Bakker AC, Webster P, Jacob WA, Andrews NW. Homotypic fusion between aggregated lysosomes triggered by elevated [Ca2+]i in fibroblasts. J Cell Sci. 1997 Sep; 110 ( Pt 18):2227-38. PMID: 9378772.
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    53. Rodríguez A, Webster P, Ortego J, Andrews NW. Lysosomes behave as Ca2+-regulated exocytic vesicles in fibroblasts and epithelial cells. J Cell Biol. 1997 Apr 07; 137(1):93-104. PMID: 9105039; PMCID: PMC2139854.
    54. Burleigh BA, Caler EV, Webster P, Andrews NW. A cytosolic serine endopeptidase from Trypanosoma cruzi is required for the generation of Ca2+ signaling in mammalian cells. J Cell Biol. 1997 Feb 10; 136(3):609-20. PMID: 9024691; PMCID: PMC2134300.
    55. Rodríguez A, Samoff E, Rioult MG, Chung A, Andrews NW. Host cell invasion by trypanosomes requires lysosomes and microtubule/kinesin-mediated transport. J Cell Biol. 1996 Jul; 134(2):349-62. PMID: 8707821; PMCID: PMC2120885.
    56. Rodríguez A, Rioult MG, Ora A, Andrews NW. A trypanosome-soluble factor induces IP3 formation, intracellular Ca2+ mobilization and microfilament rearrangement in host cells. J Cell Biol. 1995 Jun; 129(5):1263-73. PMID: 7775573; PMCID: PMC2120476.
    57. Burleigh BA, Andrews NW. A 120-kDa alkaline peptidase from Trypanosoma cruzi is involved in the generation of a novel Ca(2+)-signaling factor for mammalian cells. J Biol Chem. 1995 Mar 10; 270(10):5172-80. PMID: 7890627.
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    58. Andrews NW. Lysosome recruitment during host cell invasion by Trypanosoma cruzi. Trends Cell Biol. 1995 Mar; 5(3):133-7. PMID: 14732170.
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    59. Burleigh BA, Andrews NW. The mechanisms of Trypanosoma cruzi invasion of mammalian cells. Annu Rev Microbiol. 1995; 49:175-200. PMID: 8561458.
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    60. Andrews NW, Portnoy DA. Cytolysins from intracellular pathogens. Trends Microbiol. 1994 Aug; 2(8):261-3. PMID: 7981967.
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    61. Tardieux I, Nathanson MH, Andrews NW. Role in host cell invasion of Trypanosoma cruzi-induced cytosolic-free Ca2+ transients. J Exp Med. 1994 Mar 01; 179(3):1017-22. PMID: 8113670; PMCID: PMC2191425.
    62. Andrews NW. From lysosomes into the cytosol: the intracellular pathway of Trypanosoma cruzi. Braz J Med Biol Res. 1994 Feb; 27(2):471-5. PMID: 8081267.
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    63. Andrews NW. Living dangerously: how Trypanosoma cruzi uses lysosomes to get inside host cells, and then escapes into the cytoplasm. Biol Res. 1993; 26(1-2):65-7. PMID: 7670547.
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    64. Tardieux I, Webster P, Ravesloot J, Boron W, Lunn JA, Heuser JE, Andrews NW. Lysosome recruitment and fusion are early events required for trypanosome invasion of mammalian cells. Cell. 1992 Dec 24; 71(7):1117-30. PMID: 1473148.
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    65. Hall BF, Webster P, Ma AK, Joiner KA, Andrews NW. Desialylation of lysosomal membrane glycoproteins by Trypanosoma cruzi: a role for the surface neuraminidase in facilitating parasite entry into the host cell cytoplasm. J Exp Med. 1992 Aug 01; 176(2):313-25. PMID: 1500849; PMCID: PMC2119312.
    66. Andrews NW, Webster P. Phagolysosomal escape by intracellular pathogens. Parasitol Today. 1991 Dec; 7(12):335-40. PMID: 15463408.
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    67. Webster P, Joiner K, Andrews NW. Why do so many surface proteins of trypanosomatids have GPI-anchors? Cell Biol Int Rep. 1991 Sep; 15(9):799-813. PMID: 1802412.
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    68. Andrews NW, Schenkman S, Ley V, Whitlow MB, Robbins ES, Nussenzweig V. Trypanosoma cruzi: mechanisms of cell-invasion and intracellular survival. Mem Inst Oswaldo Cruz. 1988 Nov; 83 Suppl 1:452-5. PMID: 3151005.
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    69. Bangs JD, Andrews NW, Hart GW, Englund PT. Posttranslational modification and intracellular transport of a trypanosome variant surface glycoprotein. J Cell Biol. 1986 Jul; 103(1):255-63. PMID: 3722267; PMCID: PMC2113794.
    70. Andrews NW, Katzin AM, Colli W. Mapping of surface glycoproteins of Trypanosoma cruzi by two-dimensional electrophoresis. A correlation with the cell invasion capacity. Eur J Biochem. 1984 May 02; 140(3):599-604. PMID: 6373254.
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