Loading...
Header Logo
Keywords
Last Name
Institution

Dr Emanuela Handman

Title[no position]
Institution[no institution name]
Address[no address]
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Gorman MA, Uboldi AD, Walsh PJ, Tan KS, Hansen G, Huyton T, Ji H, Curtis J, Kedzierski L, Papenfuss AT, Dogovski C, Perugini MA, Simpson RJ, Handman E, Parker MW. Crystal structure of the Leishmania major MIX protein: a scaffold protein that mediates protein-protein interactions. Protein Sci. 2011 Jun; 20(6):1060-8. PMID: 21465610.
      View in: PubMed
    2. Kuang Z, Lewis RS, Curtis JM, Zhan Y, Saunders BM, Babon JJ, Kolesnik TB, Low A, Masters SL, Willson TA, Kedzierski L, Yao S, Handman E, Norton RS, Nicholson SE. The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation. J Cell Biol. 2010 Jul 12; 190(1):129-41. PMID: 20603330.
      View in: PubMed
    3. Sakthianandeswaren A, Curtis JM, Elso C, Kumar B, Baldwin TM, Lopaticki S, Kedzierski L, Smyth GK, Foote SJ, Handman E. Fine mapping of Leishmania major susceptibility Locus lmr2 and evidence of a role for Fli1 in disease and wound healing. Infect Immun. 2010 Jun; 78(6):2734-44. PMID: 20368343.
      View in: PubMed
    4. Lackovic K, Parisot JP, Sleebs N, Baell JB, Debien L, Watson KG, Curtis JM, Handman E, Street IP, Kedzierski L. Inhibitors of Leishmania GDP-mannose pyrophosphorylase identified by high-throughput screening of small-molecule chemical library. Antimicrob Agents Chemother. 2010 May; 54(5):1712-9. PMID: 20160053.
      View in: PubMed
    5. Sakthianandeswaren A, Foote SJ, Handman E. The role of host genetics in leishmaniasis. Trends Parasitol. 2009 Aug; 25(8):383-91. PMID: 19617002.
      View in: PubMed
    6. Zhu Y, Davis A, Smith BJ, Curtis J, Handman E. Leishmania major CorA-like magnesium transporters play a critical role in parasite development and virulence. Int J Parasitol. 2009 May; 39(6):713-23. PMID: 19136005.
      View in: PubMed
    7. Kedzierski L, Curtis JM, Doherty PC, Handman E, Kedzierska K. Decreased IL-10 and IL-13 production and increased CD44hi T cell recruitment contribute to Leishmania major immunity induced by non-persistent parasites. Eur J Immunol. 2008 Nov; 38(11):3090-100. PMID: 18924210.
      View in: PubMed
    8. Zíková A, Panigrahi AK, Uboldi AD, Dalley RA, Handman E, Stuart K. Structural and functional association of Trypanosoma brucei MIX protein with cytochrome c oxidase complex. Eukaryot Cell. 2008 Nov; 7(11):1994-2003. PMID: 18776036.
      View in: PubMed
    9. Handman E, Kedzierski L, Uboldi AD, Goding JW. Fishing for anti-leishmania drugs: principles and problems. Adv Exp Med Biol. 2008; 625:48-60. PMID: 18365658.
      View in: PubMed
    10. Baldwin T, Sakthianandeswaren A, Curtis JM, Kumar B, Smyth GK, Foote SJ, Handman E. Wound healing response is a major contributor to the severity of cutaneous leishmaniasis in the ear model of infection. Parasite Immunol. 2007 Oct; 29(10):501-13. PMID: 17883453.
      View in: PubMed
    11. McConville MJ, Handman E. The molecular basis of Leishmania pathogenesis. Int J Parasitol. 2007 Aug; 37(10):1047-51. PMID: 17629957.
      View in: PubMed
    12. Uboldi AD, Lueder FB, Walsh P, Spurck T, McFadden GI, Curtis J, Likic VA, Perugini MA, Barson M, Lithgow T, Handman E. A mitochondrial protein affects cell morphology, mitochondrial segregation and virulence in Leishmania. Int J Parasitol. 2006 Dec; 36(14):1499-514. PMID: 17011565.
      View in: PubMed
    13. Kedzierski L, Malby RL, Smith BJ, Perugini MA, Hodder AN, Ilg T, Colman PM, Handman E. Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms. J Mol Biol. 2006 Oct 13; 363(1):215-27. PMID: 16963079.
      View in: PubMed
    14. Lahoud MH, Proietto AI, Gartlan KH, Kitsoulis S, Curtis J, Wettenhall J, Sofi M, Daunt C, O'keeffe M, Caminschi I, Satterley K, Rizzitelli A, Schnorrer P, Hinohara A, Yamaguchi Y, Wu L, Smyth G, Handman E, Shortman K, Wright MD. Signal regulatory protein molecules are differentially expressed by CD8- dendritic cells. J Immunol. 2006 Jul 01; 177(1):372-82. PMID: 16785533.
      View in: PubMed
    15. Mullin KA, Lim L, Ralph SA, Spurck TP, Handman E, McFadden GI. Membrane transporters in the relict plastid of malaria parasites. Proc Natl Acad Sci U S A. 2006 Jun 20; 103(25):9572-7. PMID: 16760253.
      View in: PubMed
    16. Caminschi I, Corbett AJ, Zahra C, Lahoud M, Lucas KM, Sofi M, Vremec D, Gramberg T, Pöhlmann S, Curtis J, Handman E, van Dommelen SL, Fleming P, Degli-Esposti MA, Shortman K, Wright MD. Functional comparison of mouse CIRE/mouse DC-SIGN and human DC-SIGN. Int Immunol. 2006 May; 18(5):741-53. PMID: 16569675.
      View in: PubMed
    17. Naderer T, Ellis MA, Sernee MF, De Souza DP, Curtis J, Handman E, McConville MJ. Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase. Proc Natl Acad Sci U S A. 2006 Apr 04; 103(14):5502-7. PMID: 16569701.
      View in: PubMed
    18. Kedzierski L, Zhu Y, Handman E. Leishmania vaccines: progress and problems. Parasitology. 2006; 133 Suppl:S87-112. PMID: 17274851.
      View in: PubMed
    19. Foote SJ, Handman E. Genetics of murine leishmaniasis. Brief Funct Genomic Proteomic. 2005 Nov; 4(3):270-6. PMID: 16420752.
      View in: PubMed
    20. Sakthianandeswaren A, Elso CM, Simpson K, Curtis JM, Kumar B, Speed TP, Handman E, Foote SJ. The wound repair response controls outcome to cutaneous leishmaniasis. Proc Natl Acad Sci U S A. 2005 Oct 25; 102(43):15551-6. PMID: 16223880.
      View in: PubMed
    21. Stewart J, Curtis J, Spurck TP, Ilg T, Garami A, Baldwin T, Courret N, McFadden GI, Davis A, Handman E. Characterisation of a Leishmania mexicana knockout lacking guanosine diphosphate-mannose pyrophosphorylase. Int J Parasitol. 2005 Jul; 35(8):861-73. PMID: 15936761.
      View in: PubMed
    22. Perugini MA, Griffin MD, Smith BJ, Webb LE, Davis AJ, Handman E, Gerrard JA. Insight into the self-association of key enzymes from pathogenic species. Eur Biophys J. 2005 Jul; 34(5):469-76. PMID: 15981001.
      View in: PubMed
    23. Cody SH, Xiang SD, Layton MJ, Handman E, Lam MH, Layton JE, Nice EC, Heath JK. A simple method allowing DIC imaging in conjunction with confocal microscopy. J Microsc. 2005 Mar; 217(Pt 3):265-74. PMID: 15725130.
      View in: PubMed
    24. Handman E, Elso C, Foote S. Genes and susceptibility to leishmaniasis. Adv Parasitol. 2005; 59:1-75. PMID: 16182864.
      View in: PubMed
    25. Foth BJ, Stimmler LM, Handman E, Crabb BS, Hodder AN, McFadden GI. The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast. Mol Microbiol. 2005 Jan; 55(1):39-53. PMID: 15612915.
      View in: PubMed
    26. Tonkin CJ, van Dooren GG, Spurck TP, Struck NS, Good RT, Handman E, Cowman AF, McFadden GI. Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method. Mol Biochem Parasitol. 2004 Sep; 137(1):13-21. PMID: 15279947.
      View in: PubMed
    27. Brender C, Columbus R, Metcalf D, Handman E, Starr R, Huntington N, Tarlinton D, Ødum N, Nicholson SE, Nicola NA, Hilton DJ, Alexander WS. SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function. Mol Cell Biol. 2004 Jul; 24(13):6094-103. PMID: 15199163.
      View in: PubMed
    28. Elso C, Kumar B, Smyth G, Foote S, Handman E. Dissociation of disease susceptibility, inflammation and cytokine profile in lmr1/2 congenic mice infected with Leishmania major. Genes Immun. 2004 May; 5(3):188-96. PMID: 14762398.
      View in: PubMed
    29. Rose K, Curtis J, Baldwin T, Mathis A, Kumar B, Sakthianandeswaren A, Spurck T, Low Choy J, Handman E. Cutaneous leishmaniasis in red kangaroos: isolation and characterisation of the causative organisms. Int J Parasitol. 2004 May; 34(6):655-64. PMID: 15111087.
      View in: PubMed
    30. Kedzierski L, Montgomery J, Bullen D, Curtis J, Gardiner E, Jimenez-Ruiz A, Handman E. A leucine-rich repeat motif of Leishmania parasite surface antigen 2 binds to macrophages through the complement receptor 3. J Immunol. 2004 Apr 15; 172(8):4902-6. PMID: 15067069.
      View in: PubMed
    31. Baldwin T, Henri S, Curtis J, O'Keeffe M, Vremec D, Shortman K, Handman E. Dendritic cell populations in Leishmania major-infected skin and draining lymph nodes. Infect Immun. 2004 Apr; 72(4):1991-2001. PMID: 15039319.
      View in: PubMed
    32. Kedzierski L, Montgomery J, Curtis J, Handman E. Leucine-rich repeats in host-pathogen interactions. Arch Immunol Ther Exp (Warsz). 2004 Mar-Apr; 52(2):104-12. PMID: 15179324.
      View in: PubMed
    33. Elso CM, Roberts LJ, Smyth GK, Thomson RJ, Baldwin TM, Foote SJ, Handman E. Leishmaniasis host response loci (lmr1-3) modify disease severity through a Th1/Th2-independent pathway. Genes Immun. 2004 Mar; 5(2):93-100. PMID: 14668789.
      View in: PubMed
    34. Davis AJ, Murray HW, Handman E. Drugs against leishmaniasis: a synergy of technology and partnerships. Trends Parasitol. 2004 Feb; 20(2):73-6. PMID: 14747020.
      View in: PubMed
    35. Davis AJ, Perugini MA, Smith BJ, Stewart JD, Ilg T, Hodder AN, Handman E. Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana. J Biol Chem. 2004 Mar 26; 279(13):12462-8. PMID: 14718535.
      View in: PubMed
    36. Baldwin TM, Elso C, Curtis J, Buckingham L, Handman E. The site of Leishmania major infection determines disease severity and immune responses. Infect Immun. 2003 Dec; 71(12):6830-4. PMID: 14638769.
      View in: PubMed
    37. de Veer MJ, Curtis JM, Baldwin TM, DiDonato JA, Sexton A, McConville MJ, Handman E, Schofield L. MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll-like receptor 2 signaling. Eur J Immunol. 2003 Oct; 33(10):2822-31. PMID: 14515266.
      View in: PubMed
    38. Bullen DV, Baldwin TM, Curtis JM, Alexander WS, Handman E. Persistence of lesions in suppressor of cytokine signaling-1-deficient mice infected with Leishmania major. J Immunol. 2003 Apr 15; 170(8):4267-72. PMID: 12682261.
      View in: PubMed
    39. Bullen DV, Hansen DS, Siomos MA, Schofield L, Alexander WS, Handman E. The lack of suppressor of cytokine signalling-1 (SOCS1) protects mice from the development of cerebral malaria caused by Plasmodium berghei ANKA. Parasite Immunol. 2003 Mar; 25(3):113-8. PMID: 12911518.
      View in: PubMed
    40. Foth B, Piani A, Curtis JM, Ilg T, McConville M, Handman E. Leishmania major proteophosphoglycans exist as membrane-bound and soluble forms and localise to the cell membrane, the flagellar pocket and the lysosome. Int J Parasitol. 2002 Dec 19; 32(14):1701-8. PMID: 12464416.
      View in: PubMed
    41. Corcoran L, Vremec D, Febbraio M, Baldwin T, Handman E. Differential regulation of CD36 expression in antigen-presenting cells: Oct-2 dependence in B lymphocytes but not dendritic cells or macrophages. Int Immunol. 2002 Oct; 14(10):1099-104. PMID: 12356675.
      View in: PubMed
    42. Handman E, Bullen DV. Interaction of Leishmania with the host macrophage. Trends Parasitol. 2002 Aug; 18(8):332-4. PMID: 12377273.
      View in: PubMed
    43. Henri S, Curtis J, Hochrein H, Vremec D, Shortman K, Handman E. Hierarchy of susceptibility of dendritic cell subsets to infection by Leishmania major: inverse relationship to interleukin-12 production. Infect Immun. 2002 Jul; 70(7):3874-80. PMID: 12065531.
      View in: PubMed
    44. Croker BA, Handman E, Hayball JD, Baldwin TM, Voigt V, Cluse LA, Yang FC, Williams DA, Roberts AW. Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses. Immunol Cell Biol. 2002 Jun; 80(3):231-40. PMID: 12067410.
      View in: PubMed
    45. Montgomery J, Curtis J, Handman E. Genetic and structural heterogeneity of proteophosphoglycans in Leishmania. Mol Biochem Parasitol. 2002 Apr 30; 121(1):75-85. PMID: 11985864.
      View in: PubMed
    46. Jensen AT, Curtis J, Montgomery J, Handman E, Theander TG. Molecular and immunological characterisation of the glucose regulated protein 78 of Leishmania donovani(1). Biochim Biophys Acta. 2001 Sep 10; 1549(1):73-87. PMID: 11566370.
      View in: PubMed
    47. Bullen DV, Darwiche R, Metcalf D, Handman E, Alexander WS. Neutralization of interferon-gamma in neonatal SOCS1-/- mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease. Immunology. 2001 Sep; 104(1):92-8. PMID: 11576226.
      View in: PubMed
    48. Simpson L, Handman E. Meeting report: WorldLeish 2, Crete, Greece, May 20-24, 2001. Protist. 2001 Sep; 152(3):169-73. PMID: 11693655.
      View in: PubMed
    49. Noormohammadi AH, Hochrein H, Curtis JM, Baldwin TM, Handman E. Paradoxical effects of IL-12 in leishmaniasis in the presence and absence of vaccinating antigen. Vaccine. 2001 Jul 16; 19(28-29):4043-52. PMID: 11427281.
      View in: PubMed
    50. Henri S, Vremec D, Kamath A, Waithman J, Williams S, Benoist C, Burnham K, Saeland S, Handman E, Shortman K. The dendritic cell populations of mouse lymph nodes. J Immunol. 2001 Jul 15; 167(2):741-8. PMID: 11441078.
      View in: PubMed
    51. Jensen AT, Kemp K, Theander TG, Handman E. Cloning, expression and antigenicity of the L. donovani reductase. APMIS. 2001 Jun; 109(6):461-8. PMID: 11506479.
      View in: PubMed
    52. Handman E. Leishmaniasis: current status of vaccine development. Clin Microbiol Rev. 2001 Apr; 14(2):229-43. PMID: 11292637.
      View in: PubMed
    53. Handman E. Leishmania virulence: it's a knock out! Trends Parasitol. 2001 Feb; 17(2):60. PMID: 11228002.
      View in: PubMed
    54. Roberts LJ, Handman E, Foote SJ. Science, medicine, and the future: Leishmaniasis. BMJ. 2000 Sep 30; 321(7264):801-4. PMID: 11009521.
      View in: PubMed
    55. Scott CL, Roe L, Curtis J, Baldwin T, Robb L, Begley CG, Handman E. Mice unresponsive to GM-CSF are unexpectedly resistant to cutaneous Leishmania major infection. Microbes Infect. 2000 Aug; 2(10):1131-8. PMID: 11008103.
      View in: PubMed
    56. Handman E, Noormohammadi AH, Curtis JM, Baldwin T, Sjölander A. Therapy of murine cutaneous leishmaniasis by DNA vaccination. Vaccine. 2000 Jul 01; 18(26):3011-7. PMID: 10825604.
      View in: PubMed
    57. Roberts LJ, Foote SJ, Handman E. A new standard for the assessment of disease progression in murine cutaneous leishmaniasis. Parasite Immunol. 2000 May; 22(5):231-7. PMID: 10792762.
      View in: PubMed
    58. Montgomery J, Ilg T, Thompson JK, Kobe B, Handman E. Identification and predicted structure of a leucine-rich repeat motif shared by Leishmania major proteophosphoglycan and Parasite Surface Antigen 2. Mol Biochem Parasitol. 2000 Apr 15; 107(2):289-95. PMID: 10779605.
      View in: PubMed
    59. Ilg T, Montgomery J, Stierhof YD, Handman E. Molecular cloning and characterization of a novel repeat-containing Leishmania major gene, ppg1, that encodes a membrane-associated form of proteophosphoglycan with a putative glycosylphosphatidylinositol anchor. J Biol Chem. 1999 Oct 29; 274(44):31410-20. PMID: 10531342.
      View in: PubMed
    60. Stierhof YD, Bates PA, Jacobson RL, Rogers ME, Schlein Y, Handman E, Ilg T. Filamentous proteophosphoglycan secreted by Leishmania promastigotes forms gel-like three-dimensional networks that obstruct the digestive tract of infected sandfly vectors. Eur J Cell Biol. 1999 Oct; 78(10):675-89. PMID: 10569240.
      View in: PubMed
    61. Alexander WS, Starr R, Fenner JE, Scott CL, Handman E, Sprigg NS, Corbin JE, Cornish AL, Darwiche R, Owczarek CM, Kay TW, Nicola NA, Hertzog PJ, Metcalf D, Hilton DJ. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell. 1999 Sep 03; 98(5):597-608. PMID: 10490099.
      View in: PubMed
    62. Roberts LJ, Baldwin TM, Speed TP, Handman E, Foote SJ. Chromosomes X, 9, and the H2 locus interact epistatically to control Leishmania major infection. Eur J Immunol. 1999 09; 29(9):3047-50. PMID: 10508279.
      View in: PubMed
    63. Ilg T, Handman E, Stierhof YD. Proteophosphoglycans from Leishmania promastigotes and amastigotes. Biochem Soc Trans. 1999 Aug; 27(4):518-25. PMID: 10917633.
      View in: PubMed
    64. Piani A, Ilg T, Elefanty AG, Curtis J, Handman E. Leishmania major proteophosphoglycan is expressed by amastigotes and has an immunomodulatory effect on macrophage function. Microbes Infect. 1999 Jul; 1(8):589-99. PMID: 10611735.
      View in: PubMed
    65. Handman E. Cell biology of Leishmania. Adv Parasitol. 1999; 44:1-39. PMID: 10563394.
      View in: PubMed
    66. Sjölander A, Baldwin TM, Curtis JM, Bengtsson KL, Handman E. Vaccination with recombinant Parasite Surface Antigen 2 from Leishmania major induces a Th1 type of immune response but does not protect against infection. Vaccine. 1998 Dec; 16(20):2077-84. PMID: 9796067.
      View in: PubMed
    67. Waller RF, Keeling PJ, Donald RG, Striepen B, Handman E, Lang-Unnasch N, Cowman AF, Besra GS, Roos DS, McFadden GI. Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12352-7. PMID: 9770490.
      View in: PubMed
    68. Foote SJ, Speed T, Handman E. What can bioinformatics do for parasitology research? Parasitol Today. 1998 Sep; 14(9):346-7. PMID: 17040813.
      View in: PubMed
    69. Sjölander A, Baldwin TM, Curtis JM, Handman E. Induction of a Th1 immune response and simultaneous lack of activation of a Th2 response are required for generation of immunity to leishmaniasis. J Immunol. 1998 Apr 15; 160(8):3949-57. PMID: 9558102.
      View in: PubMed
    70. Kemp M, Handman E, Kemp K, Ismail A, Mustafa MD, Kordofani AY, Bendtzen K, Kharazmi A, Theander TG. The Leishmania promastigote surface antigen-2 (PSA-2) is specifically recognised by Th1 cells in humans with naturally acquired immunity to L. major. FEMS Immunol Med Microbiol. 1998 Mar; 20(3):209-18. PMID: 9566492.
      View in: PubMed
    71. Handman E. Leishmania vaccines: old and new. Parasitol Today. 1997 Jun; 13(6):236-8. PMID: 15275077.
      View in: PubMed
    72. Roberts LJ, Baldwin TM, Curtis JM, Handman E, Foote SJ. Resistance to Leishmania major is linked to the H2 region on chromosome 17 and to chromosome 9. J Exp Med. 1997 May 05; 185(9):1705-10. PMID: 9151907.
      View in: PubMed
    73. Grigoriadis G, Zhan Y, Grumont RJ, Metcalf D, Handman E, Cheers C, Gerondakis S. The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations. EMBO J. 1996 Dec 16; 15(24):7099-107. PMID: 9003785.
      View in: PubMed
    74. Gainsford T, Willson TA, Metcalf D, Handman E, McFarlane C, Ng A, Nicola NA, Alexander WS, Hilton DJ. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14564-8. PMID: 8962092.
      View in: PubMed
    75. Ilg T, Stierhof YD, Craik D, Simpson R, Handman E, Bacic A. Purification and structural characterization of a filamentous, mucin-like proteophosphoglycan secreted by Leishmania parasites. J Biol Chem. 1996 Aug 30; 271(35):21583-96. PMID: 8702946.
      View in: PubMed
    76. Ng K, Handman E, Bacic A. Biosynthesis of lipophosphoglycan from Leishmania major: solubilization and characterization of a (beta 1-3)-galactosyltransferase. Biochem J. 1996 Jul 01; 317 ( Pt 1):247-55. PMID: 8694771.
      View in: PubMed
    77. Opat A, Ng K, Currie G, Handman E, Bacic A. Characterization of lipophosphoglycan from a ricin-resistant mutant of Leishmania major. Glycobiology. 1996 Jun; 6(4):387-97. PMID: 8842702.
      View in: PubMed
    78. Handman E, Osborn AH, Symons F, van Driel R, Cappai R. The Leishmania promastigote surface antigen 2 complex is differentially expressed during the parasite life cycle. Mol Biochem Parasitol. 1995 Nov; 74(2):189-200. PMID: 8719160.
      View in: PubMed
    79. Handman E, Symons FM, Baldwin TM, Curtis JM, Scheerlinck JP. Protective vaccination with promastigote surface antigen 2 from Leishmania major is mediated by a TH1 type of immune response. Infect Immun. 1995 Nov; 63(11):4261-7. PMID: 7591056.
      View in: PubMed
    80. Scheerlinck JP, Corcoran LM, Handman E. SCID mice reconstituted with Oct-2-deficient lymphocytes can cure Leishmania major infection and generate normal antigen-specific T cells. Immunol Lett. 1995 Mar; 45(3):215-7. PMID: 7558177.
      View in: PubMed
    81. Kelleher M, Moody SF, Mirabile P, Osborn AH, Bacic A, Handman E. Lipophosphoglycan blocks attachment of Leishmania major amastigotes to macrophages. Infect Immun. 1995 Jan; 63(1):43-50. PMID: 7806383.
      View in: PubMed
    82. Ng K, Handman E, Bacic A. Biosynthesis of lipophosphoglycan from Leishmania major: characterization of (beta 1-3)-galactosyltransferase(s). Glycobiology. 1994 Dec; 4(6):845-53. PMID: 7734847.
      View in: PubMed
    83. Aebischer T, Morris L, Handman E. Intravenous injection of irradiated Leishmania major into susceptible BALB/c mice: immunization or protective tolerance. Int Immunol. 1994 Oct; 6(10):1535-43. PMID: 7826944.
      View in: PubMed
    84. Symons FM, Murray PJ, Ji H, Simpson RJ, Osborn AH, Cappai R, Handman E. Characterization of a polymorphic family of integral membrane proteins in promastigotes of different Leishmania species. Mol Biochem Parasitol. 1994 Sep; 67(1):103-13. PMID: 7838170.
      View in: PubMed
    85. Kelleher M, Curtis JM, Sacks DL, Handman E, Bacic A. Epitope mapping of monoclonal antibodies directed against lipophosphoglycan of Leishmania major promastigotes. Mol Biochem Parasitol. 1994 Aug; 66(2):187-200. PMID: 7808469.
      View in: PubMed
    86. Cappai R, Morris L, Aebischer T, Bacic A, Curtis JM, Kelleher M, McLeod KS, Moody SF, Osborn AH, Handman E. Ricin-resistant mutants of Leishmania major which express modified lipophosphoglycan remain infective for mice. Parasitology. 1994 May; 108 ( Pt 4):397-405. PMID: 8008453.
      View in: PubMed
    87. Cappai R, Osborn AH, Handman E. Cloning and sequence of a Leishmania major homologue to the fibrillarin gene. Mol Biochem Parasitol. 1994 Apr; 64(2):353-5. PMID: 7935615.
      View in: PubMed
    88. Osborn AH, Kelleher M, Handman E, Goding JW. Anti-galactosyl antibodies that react with unmodified agarose: a potential source of artifacts in immunoaffinity chromatography. Anal Biochem. 1994 Mar; 217(2):181-4. PMID: 8203745.
      View in: PubMed
    89. Handman E, Barnett LD, Osborn AH, Goding JW, Murray PJ. Identification, characterisation and genomic cloning of a O-linked N-acetylglucosamine-containing cytoplasmic Leishmania glycoprotein. Mol Biochem Parasitol. 1993 Nov; 62(1):61-72. PMID: 8114827.
      View in: PubMed
    90. Cappai R, Osborn AH, Gleeson PA, Handman E. Cloning and characterization of a Golgi-associated GTP-binding protein homologue from Leishmania major. Mol Biochem Parasitol. 1993 Nov; 62(1):73-82. PMID: 8114828.
      View in: PubMed
    91. Moody SF, Handman E, McConville MJ, Bacic A. The structure of Leishmania major amastigote lipophosphoglycan. J Biol Chem. 1993 Sep 05; 268(25):18457-66. PMID: 8360147.
      View in: PubMed
    92. Morris L, Troutt AB, McLeod KS, Kelso A, Handman E, Aebischer T. Interleukin-4 but not gamma interferon production correlates with the severity of murine cutaneous leishmaniasis. Infect Immun. 1993 Aug; 61(8):3459-65. PMID: 8335376.
      View in: PubMed
    93. Morris L, Aebischer T, Handman E, Kelso A. Resistance of BALB/c mice to Leishmania major infection is associated with a decrease in the precursor frequency of antigen-specific CD4+ cells secreting interleukin-4. Int Immunol. 1993 Jul; 5(7):761-7. PMID: 8103672.
      View in: PubMed
    94. Elhay MJ, McConville MJ, Curtis JM, Bacic A, Handman E. Identification of truncated forms of lipophosphoglycan in mutant cloned lines of Leishmania major that are deficient in mature lipophosphoglycan. Parasitol Res. 1993; 79(5):435-8. PMID: 8415552.
      View in: PubMed
    95. Aebischer T, Moody SF, Handman E. Persistence of virulent Leishmania major in murine cutaneous leishmaniasis: a possible hazard for the host. Infect Immun. 1993 Jan; 61(1):220-6. PMID: 8093358.
      View in: PubMed
    96. Morris L, Troutt AB, Handman E, Kelso A. Changes in the precursor frequencies of IL-4 and IFN-gamma secreting CD4+ cells correlate with resolution of lesions in murine cutaneous leishmaniasis. J Immunol. 1992 Oct 15; 149(8):2715-21. PMID: 1357029.
      View in: PubMed
    97. Mosser DM, Handman E. Treatment of murine macrophages with interferon-gamma inhibits their ability to bind leishmania promastigotes. J Leukoc Biol. 1992 Oct; 52(4):369-76. PMID: 1402387.
      View in: PubMed
    98. Kurtzhals JA, Hey AS, Theander TG, Odera E, Christensen CB, Githure JI, Koech DK, Schaefer KU, Handman E, Kharazmi A. Cellular and humoral immune responses in a population from the Baringo District, Kenya to Leishmania promastigote lipophosphoglycan. Am J Trop Med Hyg. 1992 Apr; 46(4):480-8. PMID: 1575296.
      View in: PubMed
    99. Kelleher M, Bacic A, Handman E. Identification of a macrophage-binding determinant on lipophosphoglycan from Leishmania major promastigotes. Proc Natl Acad Sci U S A. 1992 Jan 01; 89(1):6-10. PMID: 1370357.
      View in: PubMed
    100. Moody SF, Handman E, Bacic A. Structure and antigenicity of the lipophosphoglycan from Leishmania major amastigotes. Glycobiology. 1991 Sep; 1(4):419-24. PMID: 1820201.
      View in: PubMed
    101. Glaser TA, Moody SF, Handman E, Bacic A, Spithill TW. An antigenically distinct lipophosphoglycan on amastigotes of Leishmania major. Mol Biochem Parasitol. 1991 Apr; 45(2):337-44. PMID: 1710036.
      View in: PubMed
    102. Kemp M, Theander TG, Handman E, Hey AS, Kurtzhals JA, Hviid L, Sørensen AL, Were JO, Koech DK, Kharazmi A. Activation of human T lymphocytes by Leishmania lipophosphoglycan. Scand J Immunol. 1991 Feb; 33(2):219-24. PMID: 1902000.
      View in: PubMed
    103. Murray PJ, Handman E, Glaser TA, Spithill TW. Leishmania major: expression and gene structure of the glycoprotein 63 molecule in virulent and avirulent clones and strains. Exp Parasitol. 1990 Oct; 71(3):294-304. PMID: 2209787.
      View in: PubMed
    104. Handman E. Study of Leishmania major-infected macrophages by use of lipophosphoglycan-specific monoclonal antibodies. Infect Immun. 1990 Jul; 58(7):2297-302. PMID: 1694823.
      View in: PubMed
    105. Elhay M, Kelleher M, Bacic A, McConville MJ, Tolson DL, Pearson TW, Handman E. Lipophosphoglycan expression and virulence in ricin-resistant variants of Leishmania major. Mol Biochem Parasitol. 1990 May; 40(2):255-67. PMID: 2362605.
      View in: PubMed
    106. Handman E, Button LL, McMaster RW. Leishmania major: production of recombinant gp63, its antigenicity and immunogenicity in mice. Exp Parasitol. 1990 May; 70(4):427-35. PMID: 2182337.
      View in: PubMed
    107. Murray PJ, Spithill TW, Handman E. The PSA-2 glycoprotein complex of Leishmania major is a glycosylphosphatidylinositol-linked promastigote surface antigen. J Immunol. 1989 Dec 15; 143(12):4221-6. PMID: 2592773.
      View in: PubMed
    108. Moll H, Mitchell GF, McConville MJ, Handman E. Evidence of T-cell recognition in mice of a purified lipophosphoglycan from Leishmania major. Infect Immun. 1989 Nov; 57(11):3349-56. PMID: 2807527.
      View in: PubMed
    109. Murray PJ, Spithill TW, Handman E. Characterization of integral membrane proteins of Leishmania major by Triton X-114 fractionation and analysis of vaccination effects in mice. Infect Immun. 1989 Jul; 57(7):2203-9. PMID: 2731987.
      View in: PubMed
    110. Corcoran LM, Metcalf D, Edwards SJ, Handman E. GM-CSF produced by recombinant vaccinia virus or in GM-CSF transgenic mice has no effect in vivo on murine cutaneous leishmaniasis. J Parasitol. 1988 Oct; 74(5):763-7. PMID: 3047351.
      View in: PubMed
    111. Elhay MJ, McConville MJ, Handman E. Immunochemical characterization of a glyco-inositol-phospholipid membrane antigen of Leishmania major. J Immunol. 1988 Aug 15; 141(4):1326-31. PMID: 3397542.
      View in: PubMed
    112. Andrews RH, Handman E, Adams M, Baverstock PR, Mitchell GF. Genetic characterization of Leishmania isolates at 37 enzyme loci. Int J Parasitol. 1988 Jun; 18(4):445-52. PMID: 3417374.
      View in: PubMed
    113. Handman E, Mitchell GF, Goding JW. Leishmania major: a very sensitive dot-blot ELISA for detection of parasites in cutaneous lesions. Mol Biol Med. 1987 Dec; 4(6):377-83. PMID: 3437821.
      View in: PubMed
    114. McConville MJ, Bacic A, Mitchell GF, Handman E. Lipophosphoglycan of Leishmania major that vaccinates against cutaneous leishmaniasis contains an alkylglycerophosphoinositol lipid anchor. Proc Natl Acad Sci U S A. 1987 Dec; 84(24):8941-5. PMID: 3480520.
      View in: PubMed
    115. Mitchell GF, Handman E. Heterologous protection in murine cutaneous leishmaniasis. Immunol Cell Biol. 1987 Oct; 65 Pt 5:387-92. PMID: 3436638.
      View in: PubMed
    116. Mitchell GF, Handman E, Moll H, McConville MJ, Spithill TW, Kidane GZ, Samaras N, Elhay MJ. Resistance and susceptibility of mice to Leishmania major: a view from Melbourne. Ann Inst Pasteur Immunol. 1987 Sep-Oct; 138(5):738-43. PMID: 3326623.
      View in: PubMed
    117. Handman E, McConville MJ, Goding JW. Carbohydrate antigens as possible parasite vaccines A case for the Leishmania glycolipid. Immunol Today. 1987; 8(6):181-5. PMID: 25290218.
      View in: PubMed
    118. Handman E, Schnur LF, Spithill TW, Mitchell GF. Passive transfer of Leishmania lipopolysaccharide confers parasite survival in macrophages. J Immunol. 1986 Dec 01; 137(11):3608-13. PMID: 3782793.
      View in: PubMed
    119. Mitchell GF, Handman E. The glycoconjugate derived from a Leishmania major receptor for macrophages is a suppressogenic, disease-promoting antigen in murine cutaneous leishmaniasis. Parasite Immunol. 1986 May; 8(3):255-63. PMID: 2425330.
      View in: PubMed
    120. Mitchell GF, Handman E, Spithill TW. Examination of variables in the vaccination of mice against cutaneous leishmaniasis using living avirulent cloned lines and killed promastigotes of Leishmania major. Int J Parasitol. 1985 Dec; 15(6):677-84. PMID: 4093239.
      View in: PubMed
    121. Handman E, Jarvis HM. Nitrocellulose-based assays for the detection of glycolipids and other antigens: mechanism of binding to nitrocellulose. J Immunol Methods. 1985 Oct 24; 83(1):113-23. PMID: 3902968.
      View in: PubMed
    122. Handman E, Mitchell GF. Immunization with Leishmania receptor for macrophages protects mice against cutaneous leishmaniasis. Proc Natl Acad Sci U S A. 1985 Sep; 82(17):5910-4. PMID: 3862105.
      View in: PubMed
    123. Mitchell GF, Handman E. T-lymphocytes recognise Leishmania glycoconjugates. Parasitol Today. 1985 Aug; 1(2):61-3. PMID: 15275612.
      View in: PubMed
    124. Handman E, Goding JW. The Leishmania receptor for macrophages is a lipid-containing glycoconjugate. EMBO J. 1985 Feb; 4(2):329-36. PMID: 4018028.
      View in: PubMed
    125. Greenblatt CL, Handman E, Mitchell GF, Battye FL, Schnur LF, Snary D. Phenotypic diversity of cloned lines of Leishmania major promastigotes. Z Parasitenkd. 1985; 71(2):141-57. PMID: 3922149.
      View in: PubMed
    126. Handman E, Greenblatt CL, Goding JW. An amphipathic sulphated glycoconjugate of Leishmania: characterization with monoclonal antibodies. EMBO J. 1984 Oct; 3(10):2301-6. PMID: 6499830.
      View in: PubMed
    127. Handman E, Jarvis HM, Mitchell GF. Leishmania major: identification of stage-specific antigens and antigens shared by promastigotes and amastigotes. Parasite Immunol. 1984 May; 6(3):223-33. PMID: 6739119.
      View in: PubMed
    128. Mitchell GF, Handman E, Spithill TW. Vaccination against cutaneous leishmaniasis in mice using nonpathogenic cloned promastigotes of Leishmania major and importance of route of injection. Aust J Exp Biol Med Sci. 1984 Apr; 62 ( Pt 2):145-53. PMID: 6466205.
      View in: PubMed
    129. Mitchell GF, Anders RF, Chapman CB, Roberts-Thomson IC, Handman E, Cruise KM, Rickard MD, Lightowlers MW, Garcia EG. Examination of strategies for vaccination against parasitic infection or disease using mouse models. Contemp Top Immunobiol. 1984; 12:323-58. PMID: 6365442.
      View in: PubMed
    130. Handman E, Hocking RE, Mitchell GF, Spithill TW. Isolation and characterization of infective and non-infective clones of Leishmania tropica. Mol Biochem Parasitol. 1983 Feb; 7(2):111-26. PMID: 6855810.
      View in: PubMed
    131. Mitchell GF, Handman E. Leishmania tropica major in mice: vaccination against cutaneous leishmaniasis in mice of high genetic susceptibility. Aust J Exp Biol Med Sci. 1983 Feb; 61(Pt 1):11-25. PMID: 6870673.
      View in: PubMed
    132. Handman E. Association of serum proteins with cultured Leishmania: a warning note. Parasite Immunol. 1983 Jan; 5(1):109-12. PMID: 6828323.
      View in: PubMed
    133. Handman E, Curtis JM. Leishmania tropica: surface antigens of intracellular and flagellate forms. Exp Parasitol. 1982 Oct; 54(2):243-9. PMID: 7128719.
      View in: PubMed
    134. Handman E, Hocking RE. Stage-specific, strain-specific, and cross-reactive antigens of Leishmania species identified by monoclonal antibodies. Infect Immun. 1982 Jul; 37(1):28-33. PMID: 6179879.
      View in: PubMed
    135. Mitchell GF, Anders RF, Brown GV, Handman E, Roberts-Thomson IC, Chapman CB, Forsyth KP, Kahl LP, Cruise KM. Analysis of infection characteristics and antiparasite immune responses in resistant compared with susceptible hosts. Immunol Rev. 1982; 61:137-88. PMID: 6174411.
      View in: PubMed
    136. Mitchell GF, Curtis JM, Scollay RG, Handman E. Resistance and abrogation of resistance to cutaneous leishmaniasis in reconstituted BALB/c nude mice. Aust J Exp Biol Med Sci. 1981 Oct; 59(Pt 5):539-54. PMID: 6976781.
      View in: PubMed
    137. Mitchell GF, Curtis JM, Handman E. Resistance to cutaneous leishmaniasis in genetically susceptible BALB/c mice. Aust J Exp Biol Med Sci. 1981 Oct; 59(Pt 5):555-65. PMID: 7325887.
      View in: PubMed
    138. Handman E, Mitchell GF, Goding JW. Identification and characterization of protein antigens of Leishmania tropica isolates. J Immunol. 1981 Feb; 126(2):508-12. PMID: 7451987.
      View in: PubMed
    139. Olobo JO, Handman E, Curtis JM, Mitchell GF. Antibodies to Leishmania tropica promastigotes during infection in mice of various genotypes. Aust J Exp Biol Med Sci. 1980 Dec; 58(6):595-601. PMID: 7271598.
      View in: PubMed
    140. Araujo FG, Handman E, Remington JS. Binding of lectins to the cell surface of Trypanosoma cruzi. J Protozool. 1980 Nov; 27(4):397-400. PMID: 7012330.
      View in: PubMed
    141. Mitchell GF, Curtis JM, Handman E, McKenzie IF. Cutaneous leishmaniasis in mice: disease patterns in reconstituted nude mice of several genotypes infected with Leishmania tropica. Aust J Exp Biol Med Sci. 1980 Oct; 58(5):521-32. PMID: 7236121.
      View in: PubMed
    142. Araujo FG, Handman E, Remington JS. Use of monoclonal antibodies to detect antigens of Toxoplasma gondii in serum and other body fluids. Infect Immun. 1980 Oct; 30(1):12-6. PMID: 7439969.
      View in: PubMed
    143. Handman E, Remington JS. Serological and immunochemical characterization of monoclonal antibodies to Toxoplasma gondii. Immunology. 1980 Aug; 40(4):579-88. PMID: 7000687.
      View in: PubMed
    144. Handman E, Remington JS. Antibody responses to toxoplasma antigens in mice infected with strains of different virulence. Infect Immun. 1980 Jul; 29(1):215-20. PMID: 7399703.
      View in: PubMed
    145. Handman E, Goding JW, Remington JS. Detection and characterization of membrane antigens of Toxoplasma gondii. J Immunol. 1980 Jun; 124(6):2578-83. PMID: 7373040.
      View in: PubMed
    146. Handman E, Chester PM, Remington JS. Delayed hypersensitivity to Toxoplasma and unrelated antigens in Toxoplasma-infected mice: induction and elicitation of delayed-type hypersensitivity by antigen-pulsed macrophages. Infect Immun. 1980 May; 28(2):524-31. PMID: 7399673.
      View in: PubMed
    147. Handman E, Burgess AW. Stimulation by granulocyte-macrophage colony-stimulating factor of Leishmania tropica killing by macrophages. J Immunol. 1979 Mar; 122(3):1134-7. PMID: 312818.
      View in: PubMed
    148. Handman E, Ceredig R, Mitchell GF. Murine cutaneous leishmaniasis: disease patterns in intact and nude mice of various genotypes and examination of some differences between normal and infected macrophages. Aust J Exp Biol Med Sci. 1979 Feb; 57(1):9-29. PMID: 314286.
      View in: PubMed
    149. Mitchell GF, Handman E, Howard RJ. Protection of mice against plasmodium and babesia infections: attempts to raise host-protective sera. Aust J Exp Biol Med Sci. 1978 Oct; 56(5):553-9. PMID: 375903.
      View in: PubMed
    150. Koufman Z, Egoz N, Greenblatt CL, Handman E, Montilio B, Even-Paz Z. Observations on immunization against cutaneous leishmaniasis in Israel. Isr J Med Sci. 1978 Feb; 14(2):218-22. PMID: 649349.
      View in: PubMed
    151. Mitchell GF, Handman E. Studies on immune responses to larval cestodes in mice: a simple mechanism of non-specific immunosuppression in Mesocestoides corti-infected mice. Aust J Exp Biol Med Sci. 1977 Oct; 55(5):615-22. PMID: 603471.
      View in: PubMed
    152. Handman E, Greenblatt CL. Promotion of leishmanial infections in non-permissive host macrophages by conditioned medium. Z Parasitenkd. 1977 Sep 21; 53(2):143-7. PMID: 919693.
      View in: PubMed
    153. Handman E, Spira DT. Growth of Leishmania amastigotes in macrophages from normal and immune mice. Z Parasitenkd. 1977 Aug 25; 53(1):75-81. PMID: 919689.
      View in: PubMed
    154. Handman E, Spira DT, Zuckerman A, Montilio B. Standardization and quality control of Leishmania tropica vaccine. J Biol Stand. 1974 Jul; 2(3):223-9. PMID: 4214819.
      View in: PubMed
    Handman's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description