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Professor Visweswaran Navaratnam

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Furusawa G, Hartzell PL, Navaratnam V. Calcium is required for ixotrophy of Aureispira sp. CCB-QB1. Microbiology. 2015 Oct; 161(10):1933-41. PMID: 26306656.
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    2. Parapini S, Olliaro P, Navaratnam V, Taramelli D, Basilico N. Stability of the antimalarial drug dihydroartemisinin under physiologically relevant conditions: implications for clinical treatment and pharmacokinetic and in vitro assays. Antimicrob Agents Chemother. 2015 Jul; 59(7):4046-52. PMID: 25918150; PMCID: PMC4468699.
    3. Liew K, Yong PV, Navaratnam V, Lim YM, Ho AS. Differential proteomic analysis on the effects of 2-methoxy-1,4-naphthoquinone towards MDA-MB-231 cell line. Phytomedicine. 2015 May 15; 22(5):517-27. PMID: 25981917.
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    4. Harun N, Hassan Z, Navaratnam V, Mansor SM, Shoaib M. Discriminative stimulus properties of mitragynine (kratom) in rats. Psychopharmacology (Berl). 2015 Jul; 232(13):2227-38. PMID: 25616583.
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    5. Reuter SE, Upton RN, Evans AM, Navaratnam V, Olliaro PL. Population pharmacokinetics of orally administered mefloquine in healthy volunteers and patients with uncomplicated Plasmodium falciparum malaria. J Antimicrob Chemother. 2015 Mar; 70(3):868-76. PMID: 25377567.
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    6. Damodaran T, Hassan Z, Navaratnam V, Muzaimi M, Ng G, Müller CP, Liao P, Dringenberg HC. Time course of motor and cognitive functions after chronic cerebral ischemia in rats. Behav Brain Res. 2014 Dec 15; 275:252-8. PMID: 25239606.
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    7. Liew K, Yong PV, Lim YM, Navaratnam V, Ho AS. 2-Methoxy-1,4-Naphthoquinone (MNQ) suppresses the invasion and migration of a human metastatic breast cancer cell line (MDA-MB-231). Toxicol In Vitro. 2014 Apr; 28(3):335-9. PMID: 24291160.
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    8. Leang R, Ros S, Duong S, Navaratnam V, Lim P, Ariey F, Kiechel JR, Ménard D, Taylor WR. Therapeutic efficacy of fixed dose artesunate-mefloquine for the treatment of acute, uncomplicated Plasmodium falciparum malaria in Kampong Speu, Cambodia. Malar J. 2013 Sep 23; 12:343. PMID: 24060207; PMCID: PMC3852322.
    9. Kumar VS, Navaratnam V. Neem (Azadirachta indica): prehistory to contemporary medicinal uses to humankind. Asian Pac J Trop Biomed. 2013 Jul; 3(7):505-14. PMID: 23835719; PMCID: PMC3695574.
    10. Hassan Z, Muzaimi M, Navaratnam V, Yusoff NH, Suhaimi FW, Vadivelu R, Vicknasingam BK, Amato D, von Hörsten S, Ismail NI, Jayabalan N, Hazim AI, Mansor SM, Müller CP. From Kratom to mitragynine and its derivatives: physiological and behavioural effects related to use, abuse, and addiction. Neurosci Biobehav Rev. 2013 Feb; 37(2):138-51. PMID: 23206666.
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    11. Nagaya D, Ramanathan S, Ravichandran M, Navaratnam V. A118G mu opioid receptor polymorphism among drug addicts in Malaysia. J Integr Neurosci. 2012 Mar; 11(1):117-22. PMID: 22744787.
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    12. Hanley A, Hubbard RB, Navaratnam V. Mortality trends in asbestosis, extrinsic allergic alveolitis and sarcoidosis in England and Wales. Respir Med. 2011 Sep; 105(9):1373-9. PMID: 21704503.
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    13. Lacaze C, Kauss T, Kiechel JR, Caminiti A, Fawaz F, Terrassin L, Cuart S, Grislain L, Navaratnam V, Ghezzoul B, Gaudin K, White NJ, Olliaro PL, Millet P. The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership. Malar J. 2011 May 23; 10:142. PMID: 21605361; PMCID: PMC3128010.
    14. Krudsood S, Looareesuwan S, Wilairatama P, Leowattana W, Tangpukdee N, Chalermrut K, Ramanathan S, Navaratnam V, Olliaro P, Vaillant M, Kiechel JR, Taylor WR. Effect of artesunate and mefloquine in combination on the Fridericia corrected QT intervals in Plasmodium falciparum infected adults from Thailand. Trop Med Int Health. 2011 Apr; 16(4):458-65. PMID: 21219551.
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    15. Yaacob NS, Hamzah N, Nik Mohamed Kamal NN, Zainal Abidin SA, Lai CS, Navaratnam V, Norazmi MN. Anticancer activity of a sub-fraction of dichloromethane extract of Strobilanthes crispus on human breast and prostate cancer cells in vitro. BMC Complement Altern Med. 2010 Aug 05; 10:42. PMID: 20684795; PMCID: PMC2924269.
    16. Krudsood S, Looareesuwan S, Tangpukdee N, Wilairatana P, Phumratanaprapin W, Leowattana W, Chalermrut K, Ramanathan S, Navaratnam V, Olliaro P, Vaillant M, Kiechel JR, Taylor WR. New fixed-dose artesunate-mefloquine formulation against multidrug-resistant Plasmodium falciparum in adults: a comparative phase IIb safety and pharmacokinetic study with standard-dose nonfixed artesunate plus mefloquine. Antimicrob Agents Chemother. 2010 Sep; 54(9):3730-7. PMID: 20547795; PMCID: PMC2935027.
    17. Venkatesh G, Majid MI, Mansor SM, Nair NK, Croft SL, Navaratnam V. In vitro and in vivo evaluation of self-microemulsifying drug delivery system of buparvaquone. Drug Dev Ind Pharm. 2010 Jun; 36(6):735-45. PMID: 20136493.
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    18. Lai CS, Mas RH, Nair NK, Mansor SM, Navaratnam V. Chemical constituents and in vitro anticancer activity of Typhonium flagelliforme (Araceae). J Ethnopharmacol. 2010 Feb 03; 127(2):486-94. PMID: 19833183.
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    19. Vicknasingam B, Narayanan S, Navaratnam V. The relative risk of HIV among IDUs not in treatment in Malaysia. AIDS Care. 2009 Aug; 21(8):984-91. PMID: 20024754.
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    20. Vicknasingam B, Narayanan S, Navaratnam V. Prevalence rates and risk factors for hepatitis C among drug users not in treatment in Malaysia. Drug Alcohol Rev. 2009 Jul; 28(4):447-54. PMID: 19594801.
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    21. Navaratnam V, Ramanathan S, Wahab MS, Siew Hua G, Mansor SM, Kiechel JR, Vaillant M, Taylor WR, Olliaro P. Tolerability and pharmacokinetics of non-fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers. Eur J Clin Pharmacol. 2009 Aug; 65(8):809-21. PMID: 19404632; PMCID: PMC2714898.
    22. Lai CS, Nair NK, Muniandy A, Mansor SM, Olliaro PL, Navaratnam V. Validation of high performance liquid chromatography-electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in clinical pharmacological studies of artesunate-amodiaquine drug combination. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 15; 877(5-6):558-62. PMID: 19147417.
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    23. Venkatesh G, Majid MI, Ramanathan S, Mansor SM, Nair NK, Croft SL, Navaratnam V. Optimization and validation of RP-HPLC-UV method with solid-phase extraction for determination of buparvaquone in human and rabbit plasma: application to pharmacokinetic study. Biomed Chromatogr. 2008 May; 22(5):535-41. PMID: 18205140.
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    24. Lai CS, Mas RH, Nair NK, Majid MI, Mansor SM, Navaratnam V. Typhonium flagelliforme inhibits cancer cell growth in vitro and induces apoptosis: an evaluation by the bioactivity guided approach. J Ethnopharmacol. 2008 Jun 19; 118(1):14-20. PMID: 18436400.
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    25. Lai CS, Nair NK, Mansor SM, Olliaro PL, Navaratnam V. An analytical method with a single extraction procedure and two separate high performance liquid chromatographic systems for the determination of artesunate, dihydroartemisinin and mefloquine in human plasma for application in clinical pharmacological studies of the drug combination. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Oct 01; 857(2):308-14. PMID: 17719858.
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    26. Venkatesh G, Ramanathan S, Nair NK, Mansor SM, Sattar MA, Khan MA, Navaratnam V. Permeability of atenolol and propranolol in the presence of dimethyl sulfoxide in rat single-pass intestinal perfusion assay with liquid chromatography/UV detection. Biomed Chromatogr. 2007 May; 21(5):484-90. PMID: 17294505.
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    27. Vicknasingam B, Navaratnam V. The use of rapid assessment methodology to compliment existing national assessment and surveillance data: a study among injecting drug users in Penang, Malaysia. Int J Drug Policy. 2008 Feb; 19(1):90-3. PMID: 18312823.
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    28. Venkatesh G, Ramanathan S, Mansor SM, Nair NK, Sattar MA, Croft SL, Navaratnam V. Development and validation of RP-HPLC-UV method for simultaneous determination of buparvaquone, atenolol, propranolol, quinidine and verapamil: a tool for the standardization of rat in situ intestinal permeability studies. J Pharm Biomed Anal. 2007 Mar 12; 43(4):1546-51. PMID: 17157469.
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    29. Simpson JA, Agbenyega T, Barnes KI, Di Perri G, Folb P, Gomes M, Krishna S, Krudsood S, Looareesuwan S, Mansor S, McIlleron H, Miller R, Molyneux M, Mwenechanya J, Navaratnam V, Nosten F, Olliaro P, Pang L, Ribeiro I, Tembo M, van Vugt M, Ward S, Weerasuriya K, Win K, White NJ. Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients. PLoS Med. 2006 Nov; 3(11):e444. PMID: 17132053; PMCID: PMC1664603.
    30. Ramanathan S, Karupiah S, Nair NK, Olliaro PL, Navaratnam V, Wernsdorfer WH, Mansor SM. A new and simple solid-phase extraction method for LC determination of pyronaridine in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25; 824(1-2):45-50. PMID: 16046285.
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    31. Olliaro PL, Nair NK, Sathasivam K, Mansor SM, Navaratnam V. Pharmacokinetics of artesunate after single oral administration to rats. BMC Pharmacol. 2001; 1:12. PMID: 11835690; PMCID: PMC65525.
    32. Krishna S, Planche T, Agbenyega T, Woodrow C, Agranoff D, Bedu-Addo G, Owusu-Ofori AK, Appiah JA, Ramanathan S, Mansor SM, Navaratnam V. Bioavailability and preliminary clinical efficacy of intrarectal artesunate in Ghanaian children with moderate malaria. Antimicrob Agents Chemother. 2001 Feb; 45(2):509-16. PMID: 11158748; PMCID: PMC90320.
    33. Navaratnam V, Mansor SM, Sit NW, Grace J, Li Q, Olliaro P. Pharmacokinetics of artemisinin-type compounds. Clin Pharmacokinet. 2000 Oct; 39(4):255-70. PMID: 11069212.
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    34. Newton P, Suputtamongkol Y, Teja-Isavadharm P, Pukrittayakamee S, Navaratnam V, Bates I, White N. Antimalarial bioavailability and disposition of artesunate in acute falciparum malaria. Antimicrob Agents Chemother. 2000 Apr; 44(4):972-7. PMID: 10722499; PMCID: PMC89800.
    35. Navaratnam V, Mansor SM, Mordi MN, Akbar A, Abdullah MN. Comparative pharmacokinetic study of oral and rectal formulations of artesunic acid in healthy volunteers. Eur J Clin Pharmacol. 1998 Jul; 54(5):411-4. PMID: 9754985.
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    36. Qingjun L, Jihui D, Laiyi T, Xiangjun Z, Jun L, Hay A, Shires S, Navaratnam V. The effect of drug packaging on patients' compliance with treatment for Plasmodium vivax malaria in China. Bull World Health Organ. 1998; 76 Suppl 1:21-7. PMID: 9763719; PMCID: PMC2305576.
    37. Selvamuniandy TS, Mohamed N, Mansor SM, Nair NK, Navaratnam V. Determination of 6,4'-bis-(2-imidazolinylhydrazone)-2-phenylimidazo[1,2-a]py ridine in plasma and whole blood by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1997 Oct 24; 700(1-2):209-13. PMID: 9390731.
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    38. Navaratnam V, Mordi MN, Mansor SM. Simultaneous determination of artesunic acid and dihydroartemisinin in blood plasma by high-performance liquid chromatography for application in clinical pharmacological studies. J Chromatogr B Biomed Sci Appl. 1997 Apr 25; 692(1):157-62. PMID: 9187395.
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    39. Mordi MN, Mansor SM, Navaratnam V, Wernsdorfer WH. Single dose pharmacokinetics of oral artemether in healthy Malaysian volunteers. Br J Clin Pharmacol. 1997 Apr; 43(4):363-5. PMID: 9146847; PMCID: PMC2042754.
    40. Jayaraman SD, Ismail S, Nair NK, Navaratnam V. Determination of pyronaridine in blood plasma by high-performance liquid chromatography for application in clinical pharmacological studies. J Chromatogr B Biomed Sci Appl. 1997 Mar 07; 690(1-2):253-7. PMID: 9106050.
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    41. Mansor SM, Navaratnam V, Yahaya N, Nair NK, Wernsdorfer WH, Degen PH. Determination of a new antimalarial drug, benflumetol, in blood plasma by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1996 Jul 12; 682(2):321-5. PMID: 8844426.
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    42. Lokman Hakim S, Sharifah Roohi SW, Zurkurnai Y, Noor Rain A, Mansor SM, Palmer K, Navaratnam V, Mak JW. Plasmodium falciparum: increased proportion of severe resistance (RII and RIII) to chloroquine and high rate of resistance to sulfadoxine-pyrimethamine in Peninsular Malaysia after two decades. Trans R Soc Trop Med Hyg. 1996 May-Jun; 90(3):294-7. PMID: 8758083.
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    43. Restrepo M, Botero D, Marquez RE, Boudreau EF, Navaratnam V. A clinical trial with halofantrine on patients with falciparum malaria in Colombia. Bull World Health Organ. 1996; 74(6):591-7. PMID: 9060219; PMCID: PMC2486805.
    44. Navaratnam V, Mansor SM, Chin LK, Mordi MN, Asokan M, Nair NK. Determination of artemether and dihydroartemisinin in blood plasma by high-performance liquid chromatography for application in clinical pharmacological studies. J Chromatogr B Biomed Appl. 1995 Jul 21; 669(2):289-94. PMID: 7581905.
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    45. Mount DL, Todd GD, Navaratnam V. Packed-column supercritical fluid chromatography of artemisinin (qinghaosu) with electron-capture detection. J Chromatogr B Biomed Appl. 1995 Apr 07; 666(1):183-7. PMID: 7655617.
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    46. Kin F, Navaratnam V. An overview of inhalant abuse in selected countries of Asia and the Pacific Region. NIDA Res Monogr. 1995; 148:29-49. PMID: 8929883.
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    47. Ramanathan S, Nair NK, Mansor SM, Navaratnam V. Determination of the antifilarial drug UMF-078 and its metabolites UMF-060 and flubendazole in whole blood using high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1994 May 13; 655(2):269-73. PMID: 8081473.
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    48. Navaratnam V, Jamaludin A, Raman N, Mohamed M, Mansor SM. Determination of naltrexone dosage for narcotic agonist blockade in detoxified Asian addicts. Drug Alcohol Depend. 1994 Feb; 34(3):231-6. PMID: 8033761.
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    49. Ramanathan S, Nair NK, Mansor SM, Navaratnam V. Determination of a new antifilarial drug, UMF-058, and mebendazole in whole blood by high-performance liquid chromatography. J Chromatogr. 1993 Jun 02; 615(2):303-7. PMID: 8335708.
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    50. Mak JW, Navaratnam V, Grewel JS, Mansor SM, Ambu S. Treatment of subperiodic Brugia malayi infection with a single dose of ivermectin. Am J Trop Med Hyg. 1993 Apr; 48(4):591-6. PMID: 8480868.
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    51. Navaratnam V. Recent advances in the chemotherapy of lymphatic filariasis. Southeast Asian J Trop Med Public Health. 1993; 24 Suppl 2:51-4. PMID: 7973948.
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    52. Jamaludin A, Mohamad M, Navaratnam V, Yeoh PY, Wernsdorfer WH. Multiple-dose pharmacokinetic study of proguanil and cycloguanil following 12-hourly administration of 100 mg proguanil hydrochloride. Trop Med Parasitol. 1990 Sep; 41(3):268-72. PMID: 2255843.
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    53. Navaratnam V, Foong K. Opiate dependence--the role of benzodiazepines. Curr Med Res Opin. 1990; 11(10):620-30. PMID: 1968829.
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    54. Navaratnam V, Foong K. Adjunctive drug use among opiate addicts. Curr Med Res Opin. 1990; 11(10):611-9. PMID: 2311417.
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    55. Navaratnam V, Mohamad M, Hussain S, Kumar A, Jamaludin A, Sulaiman I, Mahsufi S, Selliah K. Chemosuppression of malaria by the triple combination mefloquine/sulfadoxine/pyrimethamine: a field trial in an endemic area in Malaysia. Trans R Soc Trop Med Hyg. 1989 Nov-Dec; 83(6):755-9. PMID: 2694509.
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    56. Navaratnam V, Foong K. An epidemiological assessment of drug dependence in Malaysia--a trend analysis. Med J Malaysia. 1989 Jun; 44(2):92-103. PMID: 2626130.
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    57. Mansor SM, Navaratnam V, Mohamad M, Hussein S, Kumar A, Jamaludin A, Wernsdorfer WH. Single dose kinetic study of the triple combination mefloquine/sulphadoxine/pyrimethamine (Fansimef) in healthy male volunteers. Br J Clin Pharmacol. 1989 Mar; 27(3):381-6. PMID: 2785812; PMCID: PMC1379839.
    58. Navaratnam V, Foong K. Sequence of onset of different drug use among opiate addicts. Curr Med Res Opin. 1989; 11(9):600-9. PMID: 2612204.
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    59. Navaratnam V, Foong K. Development and application of a system for monitoring drug abuse: the Malaysian experience. Bull Narc. 1989; 41(1-2):53-65. PMID: 2765720.
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    60. Jamaludin A, Mohamad M, Navaratnam V, Selliah K, Tan SC, Wernsdorfer WH, Yuen KH. Relative bioavailability of the hydrochloride, sulphate and ethyl carbonate salts of quinine. Br J Clin Pharmacol. 1988 Feb; 25(2):261-3. PMID: 3358888; PMCID: PMC1386482.
    61. Navaratnam V. Epidemiological survey of the use and abuse of agonist-antagonist analgesics in the Western Pacific region. Drug Alcohol Depend. 1987 Dec; 20(4):367-73. PMID: 2894290.
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    62. Arif A, Hughes PH, Khan I, Khant U, Klett CJ, Navaratnam V, Shafique M. Drug dependence: a methodology for evaluating treatment and rehabilitation. WHO Offset Publ. 1987; (98):1-67. PMID: 3321749.
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    63. Nair NK, Navaratnam V, Rajananda V. Analysis of illicit heroin. I. An effective thin-layer chromatographic system for separating eight opiates and five adulterants. J Chromatogr. 1986 Sep 24; 366:363-72. PMID: 3782326.
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    64. Rajananda V, Nair NK, Navaratnam V. An evaluation of TLC systems for opiate analysis. Bull Narc. 1985 Jan-Mar; 37(1):35-47. PMID: 4063572.
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    65. Bakavoli M, Navaratnam V, Nair NK. Two-dimensional thin-layer chromatographic identification of twelve 1,4-benzodiazepines. J Chromatogr. 1984 Sep 21; 299(2):465-70. PMID: 6501480.
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    66. Smart RG, Arif A, Hughes PH, Medina Mora ME, Navaratnam V, Varma VK, Wadud KA. Drug use among non-student youth. WHO Offset Publ. 1981; (60):1-58. PMID: 7336828.
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    67. Spencer C, Navaratnam V. Legal sanctions and information about drugs as influences upon the decision by adolescents whether to use illicit drugs. Drug Alcohol Depend. 1980 Nov; 6(5):315-22. PMID: 7460763.
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    68. Spencer C, Navaratnam V. Social background and attitudes towards drugs as predictors of drug use among Malaysian students. Drug Alcohol Depend. 1980 Jun; 5(6):411-9. PMID: 7379697.
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    69. Spencer C, Navaratnam V. Social attitudes, self-description and perceived reasons for using drugs: a survey of the secondary school population in Malaysia. Drug Alcohol Depend. 1980 Jun; 5(6):421-7. PMID: 7379698.
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    70. Spencer C, Navaratnam V. Patterns of drug use amongst Malaysian secondary schoolchildren. Drug Alcohol Depend. 1980 May; 5(5):379-91. PMID: 7371500.
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    71. Hughes PH, Venulet J, Khant U, Medina Mora ME, Navaratnam V, Poshyachinda V, Rootman I, Salan R, Wadud KA. Core data for epidemiological studies of nonmedical drug use. WHO Offset Publ. 1980; (56):1-100. PMID: 7324570.
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    72. Navaratnam V, Aun LB, Spencer CP. Extent and patterns of drug abuse among children in Malaysia. Bull Narc. 1979 Jul-Dec; 31(3-4):59-68. PMID: 44684.
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    73. Navaratnam V, Spencer CP. A study on socio-medical variables of drug-dependent persons volunteering for treatment in Penang, Malaysia. Bull Narc. 1978 Jan-Mar; 30(1):1-7. PMID: 352461.
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