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Dr Worachart Sirawaraporn

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Talawanich Y, Kamchonwongpaisan S, Sirawaraporn W, Yuthavong Y. Use of bacterial surrogates as a tool to explore antimalarial drug interaction: Synergism between inhibitors of malarial dihydrofolate reductase and dihydropteroate synthase. Acta Trop. 2015 Sep; 149:64-9. PMID: 25997881.
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    2. Williams K, Bilsland E, Sparkes A, Aubrey W, Young M, Soldatova LN, De Grave K, Ramon J, de Clare M, Sirawaraporn W, Oliver SG, King RD. Cheaper faster drug development validated by the repositioning of drugs against neglected tropical diseases. J R Soc Interface. 2015 Mar 06; 12(104):20141289. PMID: 25652463; PMCID: PMC4345494.
    3. Adane L, Bhagat S, Arfeen M, Bhatia S, Sirawaraporn R, Sirawaraporn W, Chakraborti AK, Bharatam PV. Design and synthesis of guanylthiourea derivatives as potential inhibitors of Plasmodium falciparum dihydrofolate reductase enzyme. Bioorg Med Chem Lett. 2014 Jan 15; 24(2):613-7. PMID: 24361001.
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    4. Chaianantakul N, Sirawaraporn R, Sirawaraporn W. Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase. Malar J. 2013 Mar 12; 12:91. PMID: 23497065; PMCID: PMC3623654.
    5. Banjara MR, Imwong M, Petmitr S, Sirawaraporn W, Joshi AB, Chavalitshewinkoon-Petmitr P. Factors associated with regional bias of pfcrt (plasmodium falciparum chloroquine resistance transporter) haplotypes in Nepal. Southeast Asian J Trop Med Public Health. 2011 Jan; 42(1):1-8. PMID: 21323158.
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    6. Banjara MR, Sirawaraporn W, Petmitr S, Imwong M, Joshi AB, Chavalitshewinkoon-Petmitr P. Characteristics and risk factors of Plasmodium falciparum malaria in Eastern and Central Nepal. Kathmandu Univ Med J (KUMJ). 2009 Oct-Dec; 7(28):378-82. PMID: 20502078.
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    7. Rattanachuen W, Jönsson M, Swedberg G, Sirawaraporn W. Probing the roles of non-homologous insertions in the N-terminal domain of Plasmodium falciparum hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase. Mol Biochem Parasitol. 2009 Dec; 168(2):135-42. PMID: 19631695.
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    8. Doungchawee G, Sirawaraporn W, Icksang-Ko A, Kongtim S, Naigowit P, Thongboonkerd V. Use of immunoblotting as an alternative method for serogrouping Leptospira. J Med Microbiol. 2007 May; 56(Pt 5):587-92. PMID: 17446278.
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    9. Sandefur CI, Wooden JM, Quaye IK, Sirawaraporn W, Sibley CH. Pyrimethamine-resistant dihydrofolate reductase enzymes of Plasmodium falciparum are not enzymatically compromised in vitro. Mol Biochem Parasitol. 2007 Jul; 154(1):1-5. PMID: 17451822; PMCID: PMC2020854.
    10. Massimine KM, McIntosh MT, Doan LT, Atreya CE, Gromer S, Sirawaraporn W, Elliott DA, Joiner KA, Schirmer RH, Anderson KS. Eosin B as a novel antimalarial agent for drug-resistant Plasmodium falciparum. Antimicrob Agents Chemother. 2006 Sep; 50(9):3132-41. PMID: 16940112; PMCID: PMC1563504.
    11. Chantratita W, Sukeepaisarncharoen W, Chandeying V, Kulpradist S, Israngkura Na Ayudhtaya B, Rugpao S, Sirawaraporn W, Boonshuyar C, Churdboonchart V. Delayed progression to AIDS in volunteers treated with long-term HIV-1 Immunogen (REMUNE) therapy in Thailand. HIV Med. 2004 Sep; 5(5):317-25. PMID: 15369506.
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    12. Kasekarn W, Sirawaraporn R, Chahomchuen T, Cowman AF, Sirawaraporn W. Molecular characterization of bifunctional hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium falciparum. Mol Biochem Parasitol. 2004 Sep; 137(1):43-53. PMID: 15279950.
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    13. Alifrangis M, Christensen IT, Jørgensen FS, Rønn AM, Weng JE, Chen M, Bygbjerg IC, Sirawaraporn W, Palarasah Y, Koch C. Homology building as a means to define antigenic epitopes on dihydrofolate reductase (DHFR) from Plasmodium falciparum. Malar J. 2004 Jun 12; 3:16. PMID: 15193156; PMCID: PMC449723.
    14. Kamchonwongpaisan S, Quarrell R, Charoensetakul N, Ponsinet R, Vilaivan T, Vanichtanankul J, Tarnchompoo B, Sirawaraporn W, Lowe G, Yuthavong Y. Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities. J Med Chem. 2004 Jan 29; 47(3):673-80. PMID: 14736247.
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    15. Berglez J, Iliades P, Sirawaraporn W, Coloe P, Macreadie I. Analysis in Escherichia coli of Plasmodium falciparum dihydropteroate synthase (DHPS) alleles implicated in resistance to sulfadoxine. Int J Parasitol. 2004 Jan; 34(1):95-100. PMID: 14711594.
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    16. Rastelli G, Pacchioni S, Sirawaraporn W, Sirawaraporn R, Parenti MD, Ferrari AM. Docking and database screening reveal new classes of Plasmodium falciparum dihydrofolate reductase inhibitors. J Med Chem. 2003 Jul 03; 46(14):2834-45. PMID: 12825927.
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    17. Yuvaniyama J, Chitnumsub P, Kamchonwongpaisan S, Vanichtanankul J, Sirawaraporn W, Taylor P, Walkinshaw MD, Yuthavong Y. Insights into antifolate resistance from malarial DHFR-TS structures. Nat Struct Biol. 2003 May; 10(5):357-65. PMID: 12704428.
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    18. Sardarian A, Douglas KT, Read M, Sims PF, Hyde JE, Chitnumsub P, Sirawaraporn R, Sirawaraporn W. Pyrimethamine analogs as strong inhibitors of double and quadruple mutants of dihydrofolate reductase in human malaria parasites. Org Biomol Chem. 2003 Mar 21; 1(6):960-4. PMID: 12929634.
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    19. Vilaivan T, Saesaengseerung N, Jarprung D, Kamchonwongpaisan S, Sirawaraporn W, Yuthavong Y. Synthesis of solution-phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum. Bioorg Med Chem. 2003 Jan 17; 11(2):217-24. PMID: 12470716.
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    20. Sirawaraporn W, Sirawaraporn R, Yongkiettrakul S, Anuwatwora A, Rastelli G, Kamchonwongpaisan S, Yuthavong Y. Mutational analysis of Plasmodium falciparum dihydrofolate reductase: the role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding. Mol Biochem Parasitol. 2002 May; 121(2):185-93. PMID: 12034452.
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    21. Tarnchompoo B, Sirichaiwat C, Phupong W, Intaraudom C, Sirawaraporn W, Kamchonwongpaisan S, Vanichtanankul J, Thebtaranonth Y, Yuthavong Y. Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum. J Med Chem. 2002 Mar 14; 45(6):1244-52. PMID: 11881993.
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    22. Chusacultanachai S, Thiensathit P, Tarnchompoo B, Sirawaraporn W, Yuthavong Y. Novel antifolate resistant mutations of Plasmodium falciparum dihydrofolate reductase selected in Escherichia coli. Mol Biochem Parasitol. 2002 Mar; 120(1):61-72. PMID: 11849706.
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    23. Leartsakulpanich U, Imwong M, Pukrittayakamee S, White NJ, Snounou G, Sirawaraporn W, Yuthavong Y. Molecular characterization of dihydrofolate reductase in relation to antifolate resistance in Plasmodium vivax. Mol Biochem Parasitol. 2002 Jan; 119(1):63-73. PMID: 11755187.
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    24. Sukeepaisarncharoen W, Churdboonchart V, Kulpradist S, Isarangkura Na Ayudthya B, Rugpao S, Chandeying V, Sirawaraporn W, Carlo D, Moss RB. Long-term follow-up of HIV-1-infected Thai patients immunized with Remune monotherapy. HIV Clin Trials. 2001 Sep-Oct; 2(5):391-8. PMID: 11673813.
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    25. Baca AM, Sirawaraporn R, Turley S, Sirawaraporn W, Hol WG. Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action. J Mol Biol. 2000 Oct 06; 302(5):1193-212. PMID: 11007651.
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    26. Macreadie I, Ginsburg H, Sirawaraporn W, Tilley L. Antimalarial drug development and new targets. Parasitol Today. 2000 Oct; 16(10):438-44. PMID: 11006476.
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    27. Churdboonchart V, Sakondhavat C, Kulpradist S, Na Ayudthya BI, Chandeying V, Rugpao S, Boonshuyar C, Sukeepaisarncharoen W, Sirawaraporn W, Carlo DJ, Moss R. A double-blind, adjuvant-controlled trial of human immunodeficiency virus type 1 (HIV-1) immunogen (Remune) monotherapy in asymptomatic, HIV-1-infected thai subjects with CD4-cell counts of >300. Clin Diagn Lab Immunol. 2000 Sep; 7(5):728-33. PMID: 10973445; PMCID: PMC95946.
    28. Yuthavong Y, Vilaivan T, Chareonsethakul N, Kamchonwongpaisan S, Sirawaraporn W, Quarrell R, Lowe G. Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum. J Med Chem. 2000 Jul 13; 43(14):2738-44. PMID: 10893311.
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    29. Rastelli G, Sirawaraporn W, Sompornpisut P, Vilaivan T, Kamchonwongpaisan S, Quarrell R, Lowe G, Thebtaranonth Y, Yuthavong Y. Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance. Bioorg Med Chem. 2000 May; 8(5):1117-28. PMID: 10882022.
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    30. Li R, Sirawaraporn R, Chitnumsub P, Sirawaraporn W, Wooden J, Athappilly F, Turley S, Hol WG. Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs. J Mol Biol. 2000 Jan 14; 295(2):307-23. PMID: 10623528.
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    31. Nopponpunth V, Sirawaraporn W, Greene PJ, Santi DV. Cloning and expression of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase in Escherichia coli. J Bacteriol. 1999 Nov; 181(21):6814-21. PMID: 10542185; PMCID: PMC94148.
    32. Churdboonchart V, Moss RB, Sirawaraporn W, Smutharaks B, Sutthent R, Jensen FC, Vacharak P, Grimes J, Theofan G, Carlo DJ. Effect of HIV-specific immune-based therapy in subjects infected with HIV-1 subtype E in Thailand. AIDS. 1998 Aug 20; 12(12):1521-7. PMID: 9727574.
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    33. McKie JH, Douglas KT, Chan C, Roser SA, Yates R, Read M, Hyde JE, Dascombe MJ, Yuthavong Y, Sirawaraporn W. Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria. J Med Chem. 1998 Apr 23; 41(9):1367-70. PMID: 9554869.
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    34. Sirawaraporn W. Dihydrofolate reductase and antifolate resistance in malaria. Drug Resist Updat. 1998; 1(6):397-406. PMID: 17092821.
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    35. Limsuwan A, Churdboonchart V, Moss RB, Sirawaraporn W, Sutthent R, Smutharaks B, Glidden D, Trauger R, Theofan G, Carlo D. Safety and immunogenicity of REMUNE in HIV-infected Thai subjects. Vaccine. 1998 Jan-Feb; 16(2-3):142-9. PMID: 9607022.
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    36. Sirawaraporn W, Yongkiettrakul S, Sirawaraporn R, Yuthavong Y, Santi DV. Plasmodium falciparum: asparagine mutant at residue 108 of dihydrofolate reductase is an optimal antifolate-resistant single mutant. Exp Parasitol. 1997 Nov; 87(3):245-52. PMID: 9371090.
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    37. Gschwend DA, Sirawaraporn W, Santi DV, Kuntz ID. Specificity in structure-based drug design: identification of a novel, selective inhibitor of Pneumocystis carinii dihydrofolate reductase. Proteins. 1997 Sep; 29(1):59-67. PMID: 9294866.
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    38. Sirawaraporn W, Sathitkul T, Sirawaraporn R, Yuthavong Y, Santi DV. Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1124-9. PMID: 9037017; PMCID: PMC19755.
    39. Prapunwattana P, Sirawaraporn W, Yuthavong Y, Santi DV. Chemical synthesis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene. Mol Biochem Parasitol. 1996 Dec 02; 83(1):93-106. PMID: 9010845.
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    40. Davisson VJ, Sirawaraporn W, Santi DV. Expression of human thymidylate synthase in Escherichia coli. J Biol Chem. 1994 Dec 02; 269(48):30740. PMID: 7982996.
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    41. Sirawaraporn W, Prapunwattana P, Sirawaraporn R, Yuthavong Y, Santi DV. The dihydrofolate reductase domain of Plasmodium falciparum thymidylate synthase-dihydrofolate reductase. Gene synthesis, expression, and anti-folate-resistant mutants. J Biol Chem. 1993 Oct 15; 268(29):21637-44. PMID: 8408015.
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    42. Sirawaraporn W, Cao M, Santi DV, Edman JC. Cloning, expression, and characterization of Cryptococcus neoformans dihydrofolate reductase. J Biol Chem. 1993 Apr 25; 268(12):8888-92. PMID: 8473332.
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    43. Sirawaraporn W. Preparation of blotted membrane for protein microsequencing. Methods Mol Biol. 1993; 21:431-40. PMID: 8220734.
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    44. Sirawaraporn W, Edman JC, Santi DV. Purification and properties of recombinant Pneumocystis carinii dihydrofolate reductase. Protein Expr Purif. 1991 Oct-Dec; 2(5-6):313-6. PMID: 1821803.
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    45. Sirawaraporn W, Sirawaraporn R, Chanpongsri A, Jacobs WR, Santi DV. Purification and characterization of dihydrofolate reductase from wild-type and trimethoprim-resistant Mycobacterium smegmatis. Exp Parasitol. 1991 Feb; 72(2):184-90. PMID: 2009922.
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    46. Sirawaraporn W, Sirawaraporn R, Cowman AF, Yuthavong Y, Santi DV. Heterologous expression of active thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum. Biochemistry. 1990 Dec 04; 29(48):10779-85. PMID: 2176883.
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    47. Davisson VJ, Sirawaraporn W, Santi DV. Expression of human thymidylate synthase in Escherichia coli. J Biol Chem. 1989 Jun 05; 264(16):9145-8. PMID: 2656695.
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    48. Sirawaraporn W, Sertsrivanich R, Booth RG, Hansch C, Neal RA, Santi DV. Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines. Mol Biochem Parasitol. 1988 Oct; 31(1):79-85. PMID: 3185614.
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    49. Grumont R, Sirawaraporn W, Santi DV. Heterologous expression of the bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania major. Biochemistry. 1988 May 17; 27(10):3776-84. PMID: 2841973.
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    50. Sirawaraporn W, Yuthavong Y. Potentiating effect of pyrimethamine and sulfadoxine against dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium chabaudi. Antimicrob Agents Chemother. 1986 May; 29(5):899-905. PMID: 3729346; PMCID: PMC284175.
    51. Yuthavong Y, Panijpan B, Ruenwongsa P, Sirawaraporn W. Biochemical aspects of drug action and resistance in malaria parasites. Southeast Asian J Trop Med Public Health. 1985 Sep; 16(3):459-72. PMID: 3913002.
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    52. Sirawaraporn W, Yuthavong Y. Kinetic and molecular properties of dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium chabaudi. Mol Biochem Parasitol. 1984 Mar; 10(3):355-67. PMID: 6727925.
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    53. Sirawaraporn W, Panijpan B, Yuthavong Y. Plasmodium berghei: uptake and distribution of chloroquine in infected mouse erythrocytes. Exp Parasitol. 1982 Oct; 54(2):260-70. PMID: 6751843.
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