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Professor Nirbhay Kumar

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Datta D, Bansal GP, Grasperge B, Martin DS, Philipp M, Gerloff D, Ellefsen B, Hannaman D, Kumar N. Comparative functional potency of DNA vaccines encoding Plasmodium falciparum transmission blocking target antigens Pfs48/45 and Pfs25 administered alone or in combination by in vivo electroporation in rhesus macaques. Vaccine. 2017 Dec 15; 35(50):7049-7056. PMID: 29132995.
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    2. Ellekvist P, Mlambo G, Kumar N, Klaerke DA. Functional characterization of malaria parasites deficient in the K+ channel Kch2. Biochem Biophys Res Commun. 2017 11 04; 493(1):690-696. PMID: 28864420.
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    3. Kumar N. Modulation of transmission success of Plasmodium falciparum gametocytes (sexual stages) in various species of Anopheles by erythrocytic asexual stage parasites. Acta Trop. 2017 Dec; 176:263-269. PMID: 28859956.
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    4. Gopalakrishnan AM, Aly ASI, Aravind L, Kumar N. Multifunctional Involvement of a C2H2 Zinc Finger Protein (PbZfp) in Malaria Transmission, Histone Modification, and Susceptibility to DNA Damage Response. MBio. 2017 Aug 29; 8(4). PMID: 28851851.
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    5. Bansal GP, Vengesai A, Cao Y, Mduluza T, Kumar N. Antibodies elicited during natural infection in a predominantly Plasmodium falciparum transmission area cross-react with sexual stage-specific antigen in P. vivax. Acta Trop. 2017 Jun; 170:105-111. PMID: 28257812.
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    6. Datta D, Bansal GP, Gerloff DL, Ellefsen B, Hannaman D, Kumar N. Immunogenicity and malaria transmission reducing potency of Pfs48/45 and Pfs25 encoded by DNA vaccines administered by intramuscular electroporation. Vaccine. 2017 Jan 05; 35(2):264-272. PMID: 27912985.
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    7. Kumar N, Bansal GP. The Right Stand by ASM regarding Journal Impact Factors. Infect Immun. 2016 12; 84(12):3655. PMID: 27864423.
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    8. Kateera F, Nsobya SL, Tukwasibwe S, Hakizimana E, Mutesa L, Mens PF, Grobusch MP, van Vugt M, Kumar N. Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda. Acta Trop. 2016 Dec; 164:329-336. PMID: 27647575.
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    9. Paul NH, Vengesai A, Mduluza T, Chipeta J, Midzi N, Bansal GP, Kumar N. Prevalence of Plasmodium falciparum transmission reducing immunity among primary school children in a malaria moderate transmission region in Zimbabwe. Acta Trop. 2016 Nov; 163:103-8. PMID: 27491342; PMCID: PMC5007214 [Available on 11/01/17].
    10. Kateera F, Nsobya SL, Tukwasibwe S, Mens PF, Hakizimana E, Grobusch MP, Mutesa L, Kumar N, van Vugt M. Malaria case clinical profiles and Plasmodium falciparum parasite genetic diversity: a cross sectional survey at two sites of different malaria transmission intensities in Rwanda. Malar J. 2016 Apr 26; 15:237. PMID: 27113354; PMCID: PMC4845397.
    11. Juliano JJ, Parobek CM, Brazeau NF, Ngasala B, Randrianarivelojosia M, Lon C, Mwandagalirwa K, Tshefu A, Dhar R, Das BK, Hoffman I, Martinson F, Mårtensson A, Saunders DL, Kumar N, Meshnick SR. Pooled Amplicon Deep Sequencing of Candidate Plasmodium falciparum Transmission-Blocking Vaccine Antigens. Am J Trop Med Hyg. 2016 Jan; 94(1):143-6. PMID: 26503281; PMCID: PMC4710419 [Available on 01/06/17].
    12. Kumar R, Ray PC, Datta D, Bansal GP, Angov E, Kumar N. Nanovaccines for malaria using Plasmodium falciparum antigen Pfs25 attached gold nanoparticles. Vaccine. 2015 Sep 22; 33(39):5064-71. PMID: 26299750; PMCID: PMC4577455 [Available on 09/22/16].
    13. Datta D, Bansal GP, Kumar R, Ellefsen B, Hannaman D, Kumar N. Evaluation of the Impact of Codon Optimization and N-Linked Glycosylation on Functional Immunogenicity of Pfs25 DNA Vaccines Delivered by In Vivo Electroporation in Preclinical Studies in Mice. Clin Vaccine Immunol. 2015 Sep; 22(9):1013-9. PMID: 26135972; PMCID: PMC4550670.
    14. Lukianova-Hleb E, Bezek S, Szigeti R, Khodarev A, Kelley T, Hurrell A, Berba M, Kumar N, D'Alessandro U, Lapotko D. Transdermal Diagnosis of Malaria Using Vapor Nanobubbles. Emerg Infect Dis. 2015 Jul; 21(7):1122-7. PMID: 26079141; PMCID: PMC4480396.
    15. Kumar R, Ledet G, Graves R, Datta D, Robinson S, Bansal GP, Mandal T, Kumar N. Potent Functional Immunogenicity of Plasmodium falciparum Transmission-Blocking Antigen (Pfs25) Delivered with Nanoemulsion and Porous Polymeric Nanoparticles. Pharm Res. 2015 Dec; 32(12):3827-36. PMID: 26113235; PMCID: PMC4628851 [Available on 12/01/16].
    16. Sitali L, Chipeta J, Miller JM, Moonga HB, Kumar N, Moss WJ, Michelo C. Patterns of mixed Plasmodium species infections among children six years and under in selected malaria hyper-endemic communities of Zambia: population-based survey observations. BMC Infect Dis. 2015 May 02; 15:204. PMID: 25930101; PMCID: PMC4424549.
    17. Gopalakrishnan AM, Kumar N. Correction for Gopalakrishnan and Kumar, Opposing Roles for Two Molecular Forms of Replication Protein A in Rad51-Rad54-Mediated DNA Recombination in Plasmodium falciparum. MBio. 2015 Feb 03; 6(1). PMID: 25650402; PMCID: PMC4324319.
    18. Gopalakrishnan AM, Kumar N. Antimalarial action of artesunate involves DNA damage mediated by reactive oxygen species. Antimicrob Agents Chemother. 2015 Jan; 59(1):317-25. PMID: 25348537; PMCID: PMC4291367.
    19. Kübler A, Luna B, Larsson C, Ammerman NC, Andrade BB, Orandle M, Bock KW, Xu Z, Bagci U, Mollura DJ, Marshall J, Burns J, Winglee K, Ahidjo BA, Cheung LS, Klunk M, Jain SK, Kumar NP, Babu S, Sher A, Friedland JS, Elkington PT, Bishai WR. Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation. J Pathol. 2015 Feb; 235(3):431-44. PMID: 25186281; PMCID: PMC4293239.
    20. Kumar R, Nyakundi R, Kariuki T, Ozwara H, Nyamongo O, Mlambo G, Ellefsen B, Hannaman D, Kumar N. Functional evaluation of malaria Pfs25 DNA vaccine by in vivo electroporation in olive baboons. Vaccine. 2013 Jun 28; 31(31):3140-7. PMID: 23684840; PMCID: PMC3686897.
    21. Chaerkady R, Kelkar DS, Muthusamy B, Kandasamy K, Dwivedi SB, Sahasrabuddhe NA, Kim MS, Renuse S, Pinto SM, Sharma R, Pawar H, Sekhar NR, Mohanty AK, Getnet D, Yang Y, Zhong J, Dash AP, MacCallum RM, Delanghe B, Mlambo G, Kumar A, Keshava Prasad TS, Okulate M, Kumar N, Pandey A. A proteogenomic analysis of Anopheles gambiae using high-resolution Fourier transform mass spectrometry. Genome Res. 2011 Nov; 21(11):1872-81. PMID: 21795387; PMCID: PMC3205572.
    22. Midzi N, Mtapuri-Zinyowera S, Sangweme D, Paul NH, Makware G, Mapingure MP, Brouwer KC, Mudzori J, Hlerema G, Chadukura V, Mutapi F, Kumar N, Mduluza T. Efficacy of integrated school based de-worming and prompt malaria treatment on helminths -Plasmodium falciparum co-infections: A 33 months follow up study. BMC Int Health Hum Rights. 2011 Jun 22; 11:9. PMID: 21696629; PMCID: PMC3141662.
    23. Midzi N, Mtapuri-Zinyowera S, Mapingure MP, Paul NH, Sangweme D, Hlerema G, Mutsaka MJ, Tongogara F, Makware G, Chadukura V, Brouwer KC, Mutapi F, Kumar N, Mduluza T. Knowledge attitudes and practices of grade three primary schoolchildren in relation to schistosomiasis, soil transmitted helminthiasis and malaria in Zimbabwe. BMC Infect Dis. 2011 Jun 13; 11:169. PMID: 21668948; PMCID: PMC3141409.
    24. Sangweme DT, Midzi N, Zinyowera-Mutapuri S, Mduluza T, Diener-West M, Kumar N. Impact of schistosome infection on Plasmodium falciparum Malariometric indices and immune correlates in school age children in Burma Valley, Zimbabwe. PLoS Negl Trop Dis. 2010 Nov 09; 4(11):e882. PMID: 21085468; PMCID: PMC2976682.
    25. Midzi N, Mtapuri-Zinyowera S, Mapingure MP, Sangweme D, Chirehwa MT, Brouwer KC, Mudzori J, Hlerema G, Mutapi F, Kumar N, Mduluza T. Consequences of polyparasitism on anaemia among primary school children in Zimbabwe. Acta Trop. 2010 Jul-Aug; 115(1-2):103-11. PMID: 20175980.
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    26. Bhowmick IP, Kumar N, Sharma S, Coppens I, Jarori GK. Plasmodium falciparum enolase: stage-specific expression and sub-cellular localization. Malar J. 2009 Jul 30; 8:179. PMID: 19642995; PMCID: PMC2794028.
    27. Chowdhury DR, Angov E, Kariuki T, Kumar N. A potent malaria transmission blocking vaccine based on codon harmonized full length Pfs48/45 expressed in Escherichia coli. PLoS One. 2009 Jul 22; 4(7):e6352. PMID: 19623257; PMCID: PMC2709910.
    28. Sangweme D, Shiff C, Kumar N. Plasmodium yoelii: adverse outcome of non-lethal P. yoelii malaria during co-infection with Schistosoma mansoni in BALB/c mouse model. Exp Parasitol. 2009 Jul; 122(3):254-9. PMID: 19366621; PMCID: PMC2703580.
    29. Ghosh AK, Devenport M, Jethwaney D, Kalume DE, Pandey A, Anderson VE, Sultan AA, Kumar N, Jacobs-Lorena M. Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins. PLoS Pathog. 2009 Jan; 5(1):e1000265. PMID: 19148273; PMCID: PMC2613030.
    30. Moon DK, Singhal V, Kumar N, Shapiro TA, Posner GH. Antimalarial Preclinical Drug Development: A Single Oral Dose of A 5-Carbon-linked Trioxane Dimer Plus Mefloquine Cures Malaria-Infected Mice. Drug Dev Res. 2009 Jan 01; 71(1):76-81. PMID: 20686674.
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    31. Midzi N, Sangweme D, Zinyowera S, Mapingure MP, Brouwer KC, Munatsi A, Mutapi F, Mudzori J, Kumar N, Woelk G, Mduluza T. The burden of polyparasitism among primary schoolchildren in rural and farming areas in Zimbabwe. Trans R Soc Trop Med Hyg. 2008 Oct; 102(10):1039-45. PMID: 18656215.
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    32. Midzi N, Sangweme D, Zinyowera S, Mapingure MP, Brouwer KC, Kumar N, Mutapi F, Woelk G, Mduluza T. Efficacy and side effects of praziquantel treatment against Schistosoma haematobium infection among primary school children in Zimbabwe. Trans R Soc Trop Med Hyg. 2008 Aug; 102(8):759-66. PMID: 18486169.
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    33. Sitruk-Ware R, Brache V, Maguire R, Croxatto H, Kumar N, Kumar S, Montero JC, Salvatierra AM, Phillips D, Faundes A. Pharmacokinetic study to compare the absorption and tolerability of two doses of levonorgestrel following single vaginal administration of levonorgestrel in Carraguard gel: a new formulation for "dual protection" contraception. Contraception. 2007 Jun; 75(6):454-60. PMID: 17519152; PMCID: PMC1995403.
    34. Mlambo G, Mutambu SL, Mduluza T, Soko W, Mbedzi J, Chivenga J, Lanar DE, Singh S, Carucci D, Gemperli A, Kumar N. Antibody responses to Plasmodium falciparum vaccine candidate antigens in three areas distinct with respect to altitude. Acta Trop. 2006 Nov; 100(1-2):70-8. PMID: 17113021.
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    35. Cernetich A, Garver LS, Jedlicka AE, Klein PW, Kumar N, Scott AL, Klein SL. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. Infect Immun. 2006 Jun; 74(6):3190-203. PMID: 16714546; PMCID: PMC1479253.
    36. Haddad D, Maciel J, Kumar N. Infection with Plasmodium berghei boosts antibody responses primed by a DNA vaccine encoding gametocyte antigen Pbs48/45. Infect Immun. 2006 Apr; 74(4):2043-51. PMID: 16552033; PMCID: PMC1418885.
    37. Page KR, Jedlicka AE, Fakheri B, Noland GS, Kesavan AK, Scott AL, Kumar N, Manabe YC. Mycobacterium-induced potentiation of type 1 immune responses and protection against malaria are host specific. Infect Immun. 2005 Dec; 73(12):8369-80. PMID: 16299335; PMCID: PMC1307063.
    38. Nyunt M, Pisciotta J, Feldman AB, Thuma P, Scholl PF, Demirev PA, Lin JS, Shi L, Kumar N, Sullivan DJ. Detection of Plasmodium falciparum in pregnancy by laser desorption mass spectrometry. Am J Trop Med Hyg. 2005 Sep; 73(3):485-90. PMID: 16172468.
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    39. Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J Exp Med. 2005 Jan 03; 201(1):19-25. PMID: 15630134; PMCID: PMC2212757.
    40. Kongkasuriyachai D, Bartels-Andrews L, Stowers A, Collins WE, Sullivan J, Sattabongkot J, Torii M, Tsuboi T, Kumar N. Potent immunogenicity of DNA vaccines encoding Plasmodium vivax transmission-blocking vaccine candidates Pvs25 and Pvs28-evaluation of homologous and heterologous antigen-delivery prime-boost strategy. Vaccine. 2004 Aug 13; 22(23-24):3205-13. PMID: 15297075.
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    41. Bhattacharyya MK, Norris DE, Kumar N. Molecular players of homologous recombination in protozoan parasites: implications for generating antigenic variation. Infect Genet Evol. 2004 Jun; 4(2):91-8. PMID: 15157626.
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    42. Coban C, Philipp MT, Purcell JE, Keister DB, Okulate M, Martin DS, Kumar N. Induction of Plasmodium falciparum transmission-blocking antibodies in nonhuman primates by a combination of DNA and protein immunizations. Infect Immun. 2004 Jan; 72(1):253-9. PMID: 14688103; PMCID: PMC344004.
    43. Sehgal A, Kumar N, Carruthers VB, Sharma S. Translocation of ribosomal protein P0 onto the Toxoplasma gondii tachyzoite surface. Int J Parasitol. 2003 Dec; 33(14):1589-94. PMID: 14636674.
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    44. Sanchez GI, Sedegah M, Rogers WO, Jones TR, Sacci J, Witney A, Carucci DJ, Kumar N, Hoffman SL. Immunogenicity and protective efficacy of a Plasmodium yoelii Hsp60 DNA vaccine in BALB/c mice. Infect Immun. 2001 Jun; 69(6):3897-905. PMID: 11349057; PMCID: PMC98419.
    45. Sanchez GI, Carucci DJ, Sacci J, Resau JH, Rogers WO, Kumar N, Hoffman SL. Plasmodium yoelii: cloning and characterization of the gene encoding for the mitochondrial heat shock protein 60. Exp Parasitol. 1999 Dec; 93(4):181-90. PMID: 10600443.
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    46. Zhang K, Fujioka H, Lobo CA, Kitayaporn D, Aikawa M, Kumar N. Cloning and characterization of a new asparagine-rich protein in Plasmodium falciparum. Parasitol Res. 1999 Dec; 85(12):956-63. PMID: 10599917.
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    47. Lobo CA, Dhar R, Kumar N. Immunization of mice with DNA-based Pfs25 elicits potent malaria transmission-blocking antibodies. Infect Immun. 1999 Apr; 67(4):1688-93. PMID: 10085005; PMCID: PMC96515.
    48. Shi YP, Hasnain SE, Sacci JB, Holloway BP, Fujioka H, Kumar N, Wohlhueter R, Hoffman SL, Collins WE, Lal AA. Immunogenicity and in vitro protective efficacy of a recombinant multistage Plasmodium falciparum candidate vaccine. Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1615-20. PMID: 9990073; PMCID: PMC15536.
    49. Contreras CE, Ploton IN, Siliciano RF, Karp CL, Viscidi R, Kumar N. Mapping of specific and promiscuous HLA-DR-restricted T-cell epitopes on the Plasmodium falciparum 27-kilodalton sexual stage-specific antigen. Infect Immun. 1998 Aug; 66(8):3579-90. PMID: 9673236; PMCID: PMC108389.
    50. Dhar R, Zhang K, Talwar GP, Garg S, Kumar N. Inhibition of the growth and development of asexual and sexual stages of drug-sensitive and resistant strains of the human malaria parasite Plasmodium falciparum by Neem (Azadirachta indica) fractions. J Ethnopharmacol. 1998 May; 61(1):31-9. PMID: 9687079.
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    51. Moore JM, Kumar N, Shultz LD, Rajan TV. Maintenance of the human malarial parasite, Plasmodium falciparum, in scid mice and transmission of gametocytes to mosquitoes. J Exp Med. 1995 Jun 01; 181(6):2265-70. PMID: 7760012; PMCID: PMC2192049.
    52. Klotz FW, Scheller LF, Seguin MC, Kumar N, Marletta MA, Green SJ, Azad AF. Co-localization of inducible-nitric oxide synthase and Plasmodium berghei in hepatocytes from rats immunized with irradiated sporozoites. J Immunol. 1995 Apr 01; 154(7):3391-5. PMID: 7534796.
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    53. Posner GH, McGarvey DJ, Oh CH, Kumar N, Meshnick SR, Asawamahasadka W. Structure-activity relationships of lactone ring-opened analogs of the antimalarial 1,2,4-trioxane artemisinin. J Med Chem. 1995 Feb 17; 38(4):607-12. PMID: 7861408.
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    54. Lobo CA, Konings RN, Kumar N. Expression of early gametocyte-stage antigens Pfg27 and Pfs16 in synchronized gametocytes and non-gametocyte producing clones of Plasmodium falciparum. Mol Biochem Parasitol. 1994 Nov; 68(1):151-4. PMID: 7891740.
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    55. Kumar N, Nagasawa H, Sacci JB, Sina BJ, Aikawa M, Atkinson C, Uparanukraw P, Kubiak LB, Azad AF, Hollingdale MR. Expression of members of the heat-shock protein 70 family in the exoerythrocytic stages of Plasmodium berghei and Plasmodium falciparum. Parasitol Res. 1993; 79(2):109-13. PMID: 8475027.
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    56. Kumar N, Zhao Y, Graves P, Perez Folgar J, Maloy L, Zheng H. Human immune response directed against Plasmodium falciparum heat shock-related proteins. Infect Immun. 1990 May; 58(5):1408-14. PMID: 1691147; PMCID: PMC258640.
    57. Kumar N, Syin CA, Carter R, Quakyi I, Miller LH. Plasmodium falciparum gene encoding a protein similar to the 78-kDa rat glucose-regulated stress protein. Proc Natl Acad Sci U S A. 1988 Sep; 85(17):6277-81. PMID: 3045815; PMCID: PMC281952.
    58. Graves PM, Carter R, Burkot TR, Quakyi IA, Kumar N. Antibodies to Plasmodium falciparum gamete surface antigens in Papua New Guinea sera. Parasite Immunol. 1988 Mar; 10(2):209-18. PMID: 3287282.
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    59. Carter R, Kumar N, Quakyi I, Good M, Mendis K, Graves P, Miller L. Immunity to sexual stages of malaria parasites. Prog Allergy. 1988; 41:193-214. PMID: 2457216.
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    60. Quakyi IA, Carter R, Rener J, Kumar N, Good MF, Miller LH. The 230-kDa gamete surface protein of Plasmodium falciparum is also a target for transmission-blocking antibodies. J Immunol. 1987 Dec 15; 139(12):4213-7. PMID: 2447164.
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    61. Kumar N, Carter R. Biosynthesis of two stage-specific membrane proteins during transformation of Plasmodium gallinaceum zygotes into ookinetes. Mol Biochem Parasitol. 1985 Feb; 14(2):127-39. PMID: 4039406.
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