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Dr Julio Scharfstein

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Svensjö E, Nogueira de Almeida L, Vellasco L, Juliano L, Scharfstein J. Ecotin-like ISP of L. major promastigotes fine-tunes macrophage phagocytosis by limiting the pericellular release of bradykinin from surface-bound kininogens: a survival strategy based on the silencing of proinflammatory G-protein coupled kinin B2 and B1 receptors. Mediators Inflamm. 2014; 2014:143450. PMID: 25294952.
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    2. Schmitz V, Almeida LN, Svensjö E, Monteiro AC, Köhl J, Scharfstein J. C5a and bradykinin receptor cross-talk regulates innate and adaptive immunity in Trypanosoma cruzi infection. J Immunol. 2014 Oct 01; 193(7):3613-23. PMID: 25187655.
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    3. Alvarenga PH, Xu X, Oliveira F, Chagas AC, Nascimento CR, Francischetti IM, Juliano MA, Juliano L, Scharfstein J, Valenzuela JG, Ribeiro JM, Andersen JF. Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate. Arterioscler Thromb Vasc Biol. 2013 Dec; 33(12):2759-70. PMID: 24092749.
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    4. Scharfstein J, Andrade D, Svensjö E, Oliveira AC, Nascimento CR. The kallikrein-kinin system in experimental Chagas disease: a paradigm to investigate the impact of inflammatory edema on GPCR-mediated pathways of host cell invasion by Trypanosoma cruzi. Front Immunol. 2012; 3:396. PMID: 23355836.
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    5. Nico D, Feijó DF, Maran N, Morrot A, Scharfstein J, Palatnik M, Palatnik-de-Sousa CB. Resistance to visceral leishmaniasis is severely compromised in mice deficient of bradykinin B2-receptors. Parasit Vectors. 2012 Nov 14; 5:261. PMID: 23151408.
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    6. Andrade D, Serra R, Svensjö E, Lima AP, Ramos ES, Fortes FS, Morandini AC, Morandi V, Soeiro Mde N, Tanowitz HB, Scharfstein J. Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathy. Br J Pharmacol. 2012 Mar; 165(5):1333-47. PMID: 21797847.
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    7. Rust NM, Papa MP, Scovino AM, da Silva MM, Calzavara-Silva CE, Marques ET, Peçanha LM, Scharfstein J, Arruda LB. Bradykinin enhances Sindbis virus infection in human brain microvascular endothelial cells. Virology. 2012 Jan 05; 422(1):81-91. PMID: 22047990.
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    8. Svensjö E, Saraiva EM, Amendola RS, Barja-Fidalgo C, Bozza MT, Lerner EA, Teixeira MM, Scharfstein J. Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway. Microvasc Res. 2012 Mar; 83(2):185-93. PMID: 22036674.
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    9. Scharfstein J, Andrade D. Infection-associated vasculopathy in experimental chagas disease pathogenic roles of endothelin and kinin pathways. Adv Parasitol. 2011; 76:101-27. PMID: 21884889.
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    10. Monteiro AC, Scovino A, Raposo S, Gaze VM, Cruz C, Svensjö E, Narciso MS, Colombo AP, Pesquero JB, Feres-Filho E, Nguyen KA, Sroka A, Potempa J, Scharfstein J. Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis. J Immunol. 2009 Sep 15; 183(6):3700-11. PMID: 19687097.
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    11. Scharfstein J, Gomes Jde A, Correa-Oliveira R. Back to the future in Chagas disease: from animal models to patient cohort studies, progress in immunopathogenesis research. Mem Inst Oswaldo Cruz. 2009 Jul; 104 Suppl 1:187-98. PMID: 19753474.
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    12. Schmitz V, Svensjö E, Serra RR, Teixeira MM, Scharfstein J. Proteolytic generation of kinins in tissues infected by Trypanosoma cruzi depends on CXC chemokine secretion by macrophages activated via Toll-like 2 receptors. J Leukoc Biol. 2009 Jun; 85(6):1005-14. PMID: 19293401.
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    13. Villalta F, Scharfstein J, Ashton AW, Tyler KM, Guan F, Mukherjee S, Lima MF, Alvarez S, Weiss LM, Huang H, Machado FS, Tanowitz HB. Perspectives on the Trypanosoma cruzi-host cell receptor interactions. Parasitol Res. 2009 Jun; 104(6):1251-60. PMID: 19283409.
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    14. Svensjö E, Saraiva EM, Bozza MT, Oliveira SM, Lerner EA, Scharfstein J. Salivary gland homogenates of Lutzomyia longipalpis and its vasodilatory peptide maxadilan cause plasma leakage via PAC1 receptor activation. J Vasc Res. 2009; 46(5):435-46. PMID: 19176972.
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    15. Scharfstein J, Monteiro AC, Schmitz V, Svensjö E. Angiotensin-converting enzyme limits inflammation elicited by Trypanosoma cruzi cysteine proteases: a peripheral mechanism regulating adaptive immunity via the innate kinin pathway. Biol Chem. 2008 Aug; 389(8):1015-24. PMID: 18979626.
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    16. Dos Santos Monteiro AC, de Oliveira Neto OB, Del Sarto RP, de Magalhães MT, Lima JN, Lacerda AF, Oliveira RS, Scharfstein J, da Silva MC, Valencia JW, Jiménez AV, Grossi-de-Sa MF. A recombinant form of chagasin from Trypanosoma cruzi: inhibitory activity on insect cysteine proteinases. Pest Manag Sci. 2008 Jul; 64(7):755-60. PMID: 18318460.
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    17. dos Reis FC, Smith BO, Santos CC, Costa TF, Scharfstein J, Coombs GH, Mottram JC, Lima AP. The role of conserved residues of chagasin in the inhibition of cysteine peptidases. FEBS Lett. 2008 Feb 20; 582(4):485-90. PMID: 18201565.
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    18. Scharfstein J, Lima AP. Roles of naturally occurring protease inhibitors in the modulation of host cell signaling and cellular invasion by Trypanosoma cruzi. Subcell Biochem. 2008; 47:140-54. PMID: 18512348.
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    19. Monteiro AC, Schmitz V, Morrot A, de Arruda LB, Nagajyothi F, Granato A, Pesquero JB, Müller-Esterl W, Tanowitz HB, Scharfstein J. Bradykinin B2 Receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses. PLoS Pathog. 2007 Nov; 3(11):e185. PMID: 18052532.
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    20. Scharfstein J, Schmitz V, Svensjö E, Granato A, Monteiro AC. Kininogens coordinate adaptive immunity through the proteolytic release of bradykinin, an endogenous danger signal driving dendritic cell maturation. Scand J Immunol. 2007 Aug-Sep; 66(2-3):128-36. PMID: 17635790.
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    21. Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure. 2007 May; 15(5):535-43. PMID: 17502099.
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    22. Reis FC, Costa TF, Sulea T, Mezzetti A, Scharfstein J, Brömme D, Ménard R, Lima AP. The propeptide of cruzipain--a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F. FEBS J. 2007 Mar; 274(5):1224-34. PMID: 17298440.
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    23. Monteiro AC, Schmitz V, Svensjo E, Gazzinelli RT, Almeida IC, Todorov A, de Arruda LB, Torrecilhas AC, Pesquero JB, Morrot A, Bouskela E, Bonomo A, Lima AP, Müller-Esterl W, Scharfstein J. Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi. J Immunol. 2006 Nov 01; 177(9):6325-35. PMID: 17056563.
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    24. Nikolskaia OV, de A Lima AP, Kim YV, Lonsdale-Eccles JD, Fukuma T, Scharfstein J, Grab DJ. Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease. J Clin Invest. 2006 Oct; 116(10):2739-47. PMID: 16998589.
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    25. dos Reis FC, Júdice WA, Juliano MA, Juliano L, Scharfstein J, Lima AP. The substrate specificity of cruzipain 2, a cysteine protease isoform from Trypanosoma cruzi. FEMS Microbiol Lett. 2006 Jun; 259(2):215-20. PMID: 16734782.
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    26. Santos CC, Scharfstein J, Lima AP. Role of chagasin-like inhibitors as endogenous regulators of cysteine proteases in parasitic protozoa. Parasitol Res. 2006 Sep; 99(4):323-4. PMID: 16636845.
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    27. Salmon D, do Aido-Machado R, Diehl A, Leidert M, Schmetzer O, de A Lima AP, Scharfstein J, Oschkinat H, Pires JR. Solution structure and backbone dynamics of the Trypanosoma cruzi cysteine protease inhibitor chagasin. J Mol Biol. 2006 Apr 14; 357(5):1511-21. PMID: 16490204.
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    28. Aido-Machado Rd, Salmon D, Diehl A, Leidert M, Schmetzer O, de Lima AP, Scharfstein J, Oschkinat H, Pires JR. 1H, 15N and 13C assignments of the cysteine protease inhibitor chagasin from Trypanosoma cruzi. J Biomol NMR. 2006; 36 Suppl 1:30. PMID: 16680406.
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    29. Scharfstein J. Parasite cysteine proteinase interactions with alpha 2-macroglobulin or kininogens: differential pathways modulating inflammation and innate immunity in infection by pathogenic trypanosomatids. Immunobiology. 2006; 211(1-2):117-25. PMID: 16446176.
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    30. Svensjö E, Batista PR, Brodskyn CI, Silva R, Lima AP, Schmitz V, Saraiva E, Pesquero JB, Mori MA, Müller-Esterl W, Scharfstein J. Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex. Microbes Infect. 2006 Jan; 8(1):206-20. PMID: 16203170.
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    31. Penha LL, Mendonça-Previato L, Previato JO, Scharfstein J, Heise N, Lima AP. Cloning and characterization of the phosphoglucomutase of Trypanosoma cruzi and functional complementation of a Saccharomyces cerevisiae PGM null mutant. Glycobiology. 2005 Dec; 15(12):1359-67. PMID: 16037487.
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    32. Santos CC, Sant'anna C, Terres A, Cunha-e-Silva NL, Scharfstein J, de A Lima AP. Chagasin, the endogenous cysteine-protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells. J Cell Sci. 2005 Mar 01; 118(Pt 5):901-15. PMID: 15713748.
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    33. Aparicio IM, Scharfstein J, Lima AP. A new cruzipain-mediated pathway of human cell invasion by Trypanosoma cruzi requires trypomastigote membranes. Infect Immun. 2004 Oct; 72(10):5892-902. PMID: 15385491.
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    34. Aliberti J, Viola JP, Vieira-de-Abreu A, Bozza PT, Sher A, Scharfstein J. Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization. J Immunol. 2003 Jun 01; 170(11):5349-53. PMID: 12759407.
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    35. Sanderson SJ, Westrop GD, Scharfstein J, Mottram JC, Coombs GH. Functional conservation of a natural cysteine peptidase inhibitor in protozoan and bacterial pathogens. FEBS Lett. 2003 May 08; 542(1-3):12-6. PMID: 12729889.
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    36. Mukherjee S, Huang H, Weiss LM, Costa S, Scharfstein J, Tanowitz HB. Role of vasoactive mediators in the pathogenesis of Chagas' disease. Front Biosci. 2003 May 01; 8:e410-9. PMID: 12700081.
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    37. Todorov AG, Andrade D, Pesquero JB, Araujo Rde C, Bader M, Stewart J, Gera L, Müller-Esterl W, Morandi V, Goldenberg RC, Neto HC, Scharfstein J. Trypanosoma cruzi induces edematogenic responses in mice and invades cardiomyocytes and endothelial cells in vitro by activating distinct kinin receptor (B1/B2) subtypes. FASEB J. 2003 Jan; 17(1):73-5. PMID: 12424228.
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    38. Schnapp AR, Eickhoff CS, Scharfstein J, Hoft DF. Induction of B- and T-cell responses to cruzipain in the murine model of Trypanosoma cruzi infection. Microbes Infect. 2002 Jul; 4(8):805-13. PMID: 12270727.
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    39. Lalmanach G, Boulangé A, Serveau C, Lecaille F, Scharfstein J, Gauthier F, Authié E. Congopain from Trypanosoma congolense: drug target and vaccine candidate. Biol Chem. 2002 May; 383(5):739-49. PMID: 12108538.
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    40. Lima AP, Almeida PC, Tersariol IL, Schmitz V, Schmaier AH, Juliano L, Hirata IY, Müller-Esterl W, Chagas JR, Scharfstein J. Heparan sulfate modulates kinin release by Trypanosoma cruzi through the activity of cruzipain. J Biol Chem. 2002 Feb 22; 277(8):5875-81. PMID: 11726662.
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    41. Monteiro AC, Abrahamson M, Lima AP, Vannier-Santos MA, Scharfstein J. Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi. J Cell Sci. 2001 Nov; 114(Pt 21):3933-42. PMID: 11719560.
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    42. Scharfstein J, Schmitz V, Morandi V, Capella MM, Lima AP, Morrot A, Juliano L, Müller-Esterl W. Host cell invasion by Trypanosoma cruzi is potentiated by activation of bradykinin B(2) receptors. J Exp Med. 2000 Nov 06; 192(9):1289-300. PMID: 11067878.
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    43. Scharfstein J, Morrot A. A role for extracellular amastigotes in the immunopathology of Chagas disease. Mem Inst Oswaldo Cruz. 1999; 94 Suppl 1:51-63. PMID: 10677691.
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