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Dr Anthony Holder

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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Green JL, Wall RJ, Vahokoski J, Yusuf NA, Ridzuan MAM, Stanway RR, Stock J, Knuepfer E, Brady D, Martin SR, Howell SA, Pires IP, Moon RW, Molloy JE, Kursula I, Tewari R, Holder AA. Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility. J Biol Chem. 2017 Sep 11. PMID: 28893907.
      View in: PubMed
    2. Moon RW, Sharaf H, Hastings CH, Ho YS, Nair MB, Rchiad Z, Knuepfer E, Ramaprasad A, Mohring F, Amir A, Yusuf NA, Hall J, Almond N, Lau YL, Pain A, Blackman MJ, Holder AA. Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesi. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):7231-6. PMID: 27303038; PMCID: PMC4933575 [Available on 12/28/16].
    3. Crosnier C, Iqbal Z, Knuepfer E, Maciuca S, Perrin AJ, Kamuyu G, Goulding D, Bustamante LY, Miles A, Moore SC, Dougan G, Holder AA, Kwiatkowski DP, Rayner JC, Pleass RJ, Wright GJ. Binding of Plasmodium falciparum Merozoite Surface Proteins DBLMSP and DBLMSP2 to Human Immunoglobulin M Is Conserved among Broadly Diverged Sequence Variants. J Biol Chem. 2016 Jul 01; 291(27):14285-99. PMID: 27226583; PMCID: PMC4933183.
    4. Green JL, Moon RW, Whalley D, Bowyer PW, Wallace C, Rochani A, Nageshan RK, Howell SA, Grainger M, Jones HM, Ansell KH, Chapman TM, Taylor DL, Osborne SA, Baker DA, Tatu U, Holder AA. Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development. Antimicrob Agents Chemother. 2015 Dec 28; 60(3):1464-75. PMID: 26711771; PMCID: PMC4775997.
    5. Roques M, Wall RJ, Douglass AP, Ramaprasad A, Ferguson DJ, Kaindama ML, Brusini L, Joshi N, Rchiad Z, Brady D, Guttery DS, Wheatley SP, Yamano H, Holder AA, Pain A, Wickstead B, Tewari R. Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes. PLoS Pathog. 2015 Nov; 11(11):e1005273. PMID: 26565797; PMCID: PMC4643991.
    6. Guttery DS, Roques M, Holder AA, Tewari R. Commit and Transmit: Molecular Players in Plasmodium Sexual Development and Zygote Differentiation. Trends Parasitol. 2015 Dec; 31(12):676-85. PMID: 26440790.
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    7. Alam MM, Solyakov L, Bottrill AR, Flueck C, Siddiqui FA, Singh S, Mistry S, Viskaduraki M, Lee K, Hopp CS, Chitnis CE, Doerig C, Moon RW, Green JL, Holder AA, Baker DA, Tobin AB. Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion. Nat Commun. 2015 Jul 07; 6:7285. PMID: 26149123; PMCID: PMC4507021.
    8. Lasonder E, Green JL, Grainger M, Langsley G, Holder AA. Extensive differential protein phosphorylation as intraerythrocytic Plasmodium falciparum schizonts develop into extracellular invasive merozoites. Proteomics. 2015 Aug; 15(15):2716-29. PMID: 25886026.
      View in: PubMed
    9. Thavayogarajah T, Gangopadhyay P, Rahlfs S, Becker K, Lingelbach K, Przyborski JM, Holder AA. Alternative Protein Secretion in the Malaria Parasite Plasmodium falciparum. PLoS One. 2015; 10(4):e0125191. PMID: 25909331; PMCID: PMC4409355.
    10. Yusuf NA, Green JL, Wall RJ, Knuepfer E, Moon RW, Schulte-Huxel C, Stanway RR, Martin SR, Howell SA, Douse CH, Cota E, Tate EW, Tewari R, Holder AA. The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain. J Biol Chem. 2015 May 08; 290(19):12147-64. PMID: 25802338; PMCID: PMC4424349.
    11. Stallmach R, Kavishwar M, Withers-Martinez C, Hackett F, Collins CR, Howell SA, Yeoh S, Knuepfer E, Atid AJ, Holder AA, Blackman MJ. Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle. Mol Microbiol. 2015 Apr; 96(2):368-87. PMID: 25599609; PMCID: PMC4671257.
    12. Safeukui I, Gomez ND, Adelani AA, Burte F, Afolabi NK, Akondy R, Velazquez P, Holder A, Tewari R, Buffet P, Brown BJ, Shokunbi WA, Olaleye D, Sodeinde O, Kazura J, Ahmed R, Mohandas N, Fernandez-Reyes D, Haldar K. Malaria induces anemia through CD8+ T cell-dependent parasite clearance and erythrocyte removal in the spleen. MBio. 2015 Jan 20; 6(1). PMID: 25604792; PMCID: PMC4324318.
    13. Otto TD, Böhme U, Jackson AP, Hunt M, Franke-Fayard B, Hoeijmakers WA, Religa AA, Robertson L, Sanders M, Ogun SA, Cunningham D, Erhart A, Billker O, Khan SM, Stunnenberg HG, Langhorne J, Holder AA, Waters AP, Newbold CI, Pain A, Berriman M, Janse CJ. A comprehensive evaluation of rodent malaria parasite genomes and gene expression. BMC Biol. 2014 Oct 30; 12:86. PMID: 25359557; PMCID: PMC4242472.
    14. Diaz SA, Martin SR, Grainger M, Howell SA, Green JL, Holder AA. Plasmodium falciparum aldolase and the C-terminal cytoplasmic domain of certain apical organellar proteins promote actin polymerization. Mol Biochem Parasitol. 2014 Oct; 197(1-2):9-14. PMID: 25261592; PMCID: PMC4251702.
    15. Ansell KH, Jones HM, Whalley D, Hearn A, Taylor DL, Patin EC, Chapman TM, Osborne SA, Wallace C, Birchall K, Large J, Bouloc N, Smiljanic-Hurley E, Clough B, Moon RW, Green JL, Holder AA. Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1. Antimicrob Agents Chemother. 2014 Oct; 58(10):6032-43. PMID: 25070106; PMCID: PMC4187893.
    16. Guttery DS, Poulin B, Ramaprasad A, Wall RJ, Ferguson DJ, Brady D, Patzewitz EM, Whipple S, Straschil U, Wright MH, Mohamed AM, Radhakrishnan A, Arold ST, Tate EW, Holder AA, Wickstead B, Pain A, Tewari R. Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation. Cell Host Microbe. 2014 Jul 09; 16(1):128-40. PMID: 25011111; PMCID: PMC4094981.
    17. Chapman TM, Osborne SA, Wallace C, Birchall K, Bouloc N, Jones HM, Ansell KH, Taylor DL, Clough B, Green JL, Holder AA. Optimization of an imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1). J Med Chem. 2014 Apr 24; 57(8):3570-87. PMID: 24689770; PMCID: PMC4024065.
    18. Rackham MD, Brannigan JA, Rangachari K, Meister S, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW. Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP). J Med Chem. 2014 Mar 27; 57(6):2773-88. PMID: 24641010; PMCID: PMC4048319.
    19. Grüring C, Moon RW, Lim C, Holder AA, Blackman MJ, Duraisingh MT. Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research. Cell Microbiol. 2014 May; 16(5):612-20. PMID: 24506567; PMCID: PMC4004062.
    20. Elders RC, Holder A, Smith KC, Baines SJ, Catchpole B. Recombinant canine IgE Fc and an IgE Fc-TRAIL fusion protein bind to neoplastic canine mast cells. Vet Immunol Immunopathol. 2014 May 15; 159(1-2):29-40. PMID: 24690189.
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    21. Ezougou CN, Ben-Rached F, Moss DK, Lin JW, Black S, Knuepfer E, Green JL, Khan SM, Mukhopadhyay A, Janse CJ, Coppens I, Yera H, Holder AA, Langsley G. Plasmodium falciparum Rab5B is an N-terminally myristoylated Rab GTPase that is targeted to the parasite's plasma and food vacuole membranes. PLoS One. 2014; 9(2):e87695. PMID: 24498355; PMCID: PMC3912013.
    22. Curd RD, Birdsall B, Kadekoppala M, Ogun SA, Kelly G, Holder AA. The structure of Plasmodium yoelii merozoite surface protein 119, antibody specificity and implications for malaria vaccine design. Open Biol. 2014 Jan 08; 4:130091. PMID: 24403012; PMCID: PMC3909271.
    23. Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW. Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach. Nat Chem. 2014 Feb; 6(2):112-21. PMID: 24451586; PMCID: PMC4739506.
    24. Imura T, Sato S, Sato Y, Sakamoto D, Isobe T, Murata K, Holder AA, Yukawa M. The apicoplast genome of Leucocytozoon caulleryi, a pathogenic apicomplexan parasite of the chicken. Parasitol Res. 2014 Mar; 113(3):823-8. PMID: 24301182; PMCID: PMC3932168.
    25. Douglas AD, Williams AR, Knuepfer E, Illingworth JJ, Furze JM, Crosnier C, Choudhary P, Bustamante LY, Zakutansky SE, Awuah DK, Alanine DG, Theron M, Worth A, Shimkets R, Rayner JC, Holder AA, Wright GJ, Draper SJ. Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5. J Immunol. 2014 Jan 01; 192(1):245-58. PMID: 24293631; PMCID: PMC3872115.
    26. Poulin B, Patzewitz EM, Brady D, Silvie O, Wright MH, Ferguson DJ, Wall RJ, Whipple S, Guttery DS, Tate EW, Wickstead B, Holder AA, Tewari R. Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite. Biol Open. 2013; 2(11):1160-70. PMID: 24244852; PMCID: PMC3828762.
    27. Prommana P, Uthaipibull C, Wongsombat C, Kamchonwongpaisan S, Yuthavong Y, Knuepfer E, Holder AA, Shaw PJ. Inducible knockdown of Plasmodium gene expression using the glmS ribozyme. PLoS One. 2013; 8(8):e73783. PMID: 24023691; PMCID: PMC3758297.
    28. Knuepfer E, Suleyman O, Dluzewski AR, Straschil U, O'Keeffe AH, Ogun SA, Green JL, Grainger M, Tewari R, Holder AA. RON12, a novel Plasmodium-specific rhoptry neck protein important for parasite proliferation. Cell Microbiol. 2014 May; 16(5):657-72. PMID: 23937520; PMCID: PMC3922828.
    29. Large JM, Osborne SA, Smiljanic-Hurley E, Ansell KH, Jones HM, Taylor DL, Clough B, Green JL, Holder AA. Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues. Bioorg Med Chem Lett. 2013 Nov 01; 23(21):6019-24. PMID: 24035097; PMCID: PMC3809513.
    30. Heiber A, Kruse F, Pick C, Grüring C, Flemming S, Oberli A, Schoeler H, Retzlaff S, Mesén-Ramírez P, Hiss JA, Kadekoppala M, Hecht L, Holder AA, Gilberger TW, Spielmann T. Identification of new PNEPs indicates a substantial non-PEXEL exportome and underpins common features in Plasmodium falciparum protein export. PLoS Pathog. 2013; 9(8):e1003546. PMID: 23950716; PMCID: PMC3738491.
    31. Fernandez-Pol S, Slouka Z, Bhattacharjee S, Fedotova Y, Freed S, An X, Holder AA, Campanella E, Low PS, Mohandas N, Haldar K. A bacterial phosphatase-like enzyme of the malaria parasite Plasmodium falciparum possesses tyrosine phosphatase activity and is implicated in the regulation of band 3 dynamics during parasite invasion. Eukaryot Cell. 2013 Sep; 12(9):1179-91. PMID: 23825180; PMCID: PMC3811575.
    32. Lima WR, Holder AA, Garcia CR. Melatonin signaling and its modulation of PfNF-YB transcription factor expression in Plasmodium falciparum. Int J Mol Sci. 2013 Jul 01; 14(7):13704-18. PMID: 23839089; PMCID: PMC3742212.
    33. Cruz-Gallardo I, Díaz-Moreno I, Díaz-Quintana A, Donaire A, Velázquez-Campoy A, Curd RD, Rangachari K, Birdsall B, Ramos A, Holder AA, De la Rosa MA. Antimalarial activity of cupredoxins: the interaction of Plasmodium merozoite surface protein 119 (MSP119) and rusticyanin. J Biol Chem. 2013 Jul 19; 288(29):20896-907. PMID: 23749994; PMCID: PMC3774360.
    34. Sato S, Sesay AK, Holder AA. The unique structure of the apicoplast genome of the rodent malaria parasite Plasmodium chabaudi chabaudi. PLoS One. 2013; 8(4):e61778. PMID: 23613931; PMCID: PMC3627918.
    35. Chapman TM, Osborne SA, Bouloc N, Large JM, Wallace C, Birchall K, Ansell KH, Jones HM, Taylor D, Clough B, Green JL, Holder AA. Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1). Bioorg Med Chem Lett. 2013 May 15; 23(10):3064-9. PMID: 23570789; PMCID: PMC3898741.
    36. Patzewitz EM, Guttery DS, Poulin B, Ramakrishnan C, Ferguson DJ, Wall RJ, Brady D, Holder AA, Szöor B, Tewari R. An ancient protein phosphatase, SHLP1, is critical to microneme development in Plasmodium ookinetes and parasite transmission. Cell Rep. 2013 Mar 28; 3(3):622-9. PMID: 23434509; PMCID: PMC3617505.
    37. Faber BW, Younis S, Remarque EJ, Rodriguez Garcia R, Riasat V, Walraven V, van der Werff N, van der Eijk M, Cavanagh DR, Holder AA, Thomas AW, Kocken CH. Diversity covering AMA1-MSP119 fusion proteins as malaria vaccines. Infect Immun. 2013 May; 81(5):1479-90. PMID: 23429538; PMCID: PMC3648017.
    38. Moon RW, Hall J, Rangkuti F, Ho YS, Almond N, Mitchell GH, Pain A, Holder AA, Blackman MJ. Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes. Proc Natl Acad Sci U S A. 2013 Jan 08; 110(2):531-6. PMID: 23267069; PMCID: PMC3545754.
    39. Rackham MD, Brannigan JA, Moss DK, Yu Z, Wilkinson AJ, Holder AA, Tate EW, Leatherbarrow RJ. Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase. J Med Chem. 2013 Jan 10; 56(1):371-5. PMID: 23170970; PMCID: PMC3601602.
    40. Amambua-Ngwa A, Tetteh KK, Manske M, Gomez-Escobar N, Stewart LB, Deerhake ME, Cheeseman IH, Newbold CI, Holder AA, Knuepfer E, Janha O, Jallow M, Campino S, Macinnis B, Kwiatkowski DP, Conway DJ. Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites. PLoS Genet. 2012; 8(11):e1002992. PMID: 23133397; PMCID: PMC3486833.
    41. Lasonder E, Green JL, Camarda G, Talabani H, Holder AA, Langsley G, Alano P. The Plasmodium falciparum schizont phosphoproteome reveals extensive phosphatidylinositol and cAMP-protein kinase A signaling. J Proteome Res. 2012 Nov 02; 11(11):5323-37. PMID: 23025827.
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    42. Yu Z, Brannigan JA, Moss DK, Brzozowski AM, Wilkinson AJ, Holder AA, Tate EW, Leatherbarrow RJ. Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery. J Med Chem. 2012 Oct 25; 55(20):8879-90. PMID: 23035716; PMCID: PMC3863768.
    43. Guttery DS, Poulin B, Ferguson DJ, Szöor B, Wickstead B, Carroll PL, Ramakrishnan C, Brady D, Patzewitz EM, Straschil U, Solyakov L, Green JL, Sinden RE, Tobin AB, Holder AA, Tewari R. A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion. PLoS Pathog. 2012 Sep; 8(9):e1002948. PMID: 23028336; PMCID: PMC3447748.
    44. Douse CH, Green JL, Salgado PS, Simpson PJ, Thomas JC, Langsley G, Holder AA, Tate EW, Cota E. Regulation of the Plasmodium motor complex: phosphorylation of myosin A tail-interacting protein (MTIP) loosens its grip on MyoA. J Biol Chem. 2012 Oct 26; 287(44):36968-77. PMID: 22932904; PMCID: PMC3481298.
    45. Holder AA, Mohd Ridzuan MA, Green JL. Calcium dependent protein kinase 1 and calcium fluxes in the malaria parasite. Microbes Infect. 2012 Aug; 14(10):825-30. PMID: 22584104.
      View in: PubMed
    46. Bell AS, Mills JE, Williams GP, Brannigan JA, Wilkinson AJ, Parkinson T, Leatherbarrow RJ, Tate EW, Holder AA, Smith DF. Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs. PLoS Negl Trop Dis. 2012; 6(4):e1625. PMID: 22545171; PMCID: PMC3335879.
    47. Biswas S, Spencer AJ, Forbes EK, Gilbert SC, Holder AA, Hill AV, Draper SJ. Recombinant viral-vectored vaccines expressing Plasmodium chabaudi AS apical membrane antigen 1: mechanisms of vaccine-induced blood-stage protection. J Immunol. 2012 May 15; 188(10):5041-53. PMID: 22504652; PMCID: PMC3378655.
    48. Goncalves V, Brannigan JA, Whalley D, Ansell KH, Saxty B, Holder AA, Wilkinson AJ, Tate EW, Leatherbarrow RJ. Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode. J Med Chem. 2012 Apr 12; 55(7):3578-82. PMID: 22439843; PMCID: PMC3863987.
    49. Ridzuan MA, Moon RW, Knuepfer E, Black S, Holder AA, Green JL. Subcellular location, phosphorylation and assembly into the motor complex of GAP45 during Plasmodium falciparum schizont development. PLoS One. 2012; 7(3):e33845. PMID: 22479457; PMCID: PMC3316498.
    50. Cruz LN, Juliano MA, Budu A, Juliano L, Holder AA, Blackman MJ, Garcia CR. Extracellular ATP triggers proteolysis and cytosolic Ca²? rise in Plasmodium berghei and Plasmodium yoelii malaria parasites. Malar J. 2012 Mar 15; 11:69. PMID: 22420332; PMCID: PMC3358241.
    51. Guttery DS, Ferguson DJ, Poulin B, Xu Z, Straschil U, Klop O, Solyakov L, Sandrini SM, Brady D, Nieduszynski CA, Janse CJ, Holder AA, Tobin AB, Tewari R. A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development. PLoS Pathog. 2012 Feb; 8(2):e1002554. PMID: 22383885; PMCID: PMC3285604.
    52. Guttery DS, Holder AA, Tewari R. Sexual development in Plasmodium: lessons from functional analyses. PLoS Pathog. 2012 Jan; 8(1):e1002404. PMID: 22275863; PMCID: PMC3262008.
    53. Moss DK, Remarque EJ, Faber BW, Cavanagh DR, Arnot DE, Thomas AW, Holder AA. Plasmodium falciparum 19-kilodalton merozoite surface protein 1 (MSP1)-specific antibodies that interfere with parasite growth in vitro can inhibit MSP1 processing, merozoite invasion, and intracellular parasite development. Infect Immun. 2012 Mar; 80(3):1280-7. PMID: 22202121; PMCID: PMC3294643.
    54. Bisseye C, Yindom LM, Simporé J, Morgan WD, Holder AA, Ismaili J. An engineered Plasmodium falciparum C-terminal 19-kilodalton merozoite surface protein 1 vaccine candidate induces high levels of interferon-gamma production associated with cellular immune responses to specific peptide sequences in Gambian adults naturally exposed to malaria. Clin Exp Immunol. 2011 Dec; 166(3):366-73. PMID: 22059995; PMCID: PMC3232385.
    55. Farrow RE, Green J, Katsimitsoulia Z, Taylor WR, Holder AA, Molloy JE. The mechanism of erythrocyte invasion by the malarial parasite, Plasmodium falciparum. Semin Cell Dev Biol. 2011 Dec; 22(9):953-60. PMID: 22001249.
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    56. Gómez ND, Safeukui I, Adelani AA, Tewari R, Reddy JK, Rao S, Holder A, Buffet P, Mohandas N, Haldar K. Deletion of a malaria invasion gene reduces death and anemia, in model hosts. PLoS One. 2011; 6(9):e25477. PMID: 21980474; PMCID: PMC3182240.
    57. Thøgersen RL, Holder AA, Hill AV, Arnot DE, Imoukhuede EB, Leroy O. Comparative decline in funding of European Commission malaria vaccine projects: what next for the European scientists working in this field? Malar J. 2011 Sep 01; 10:255. PMID: 21880156; PMCID: PMC3196926.
    58. Shi J, McIntosh RS, Adame-Gallegos J, Dehal PK, van Egmond M, van de Winkel J, Draper SJ, Forbes EK, Corran PH, Holder AA, Woof JM, Pleass RJ. The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19). BMC Biotechnol. 2011 Jul 22; 11:77. PMID: 21781305; PMCID: PMC3199766.
    59. Biswas S, Dicks MD, Long CA, Remarque EJ, Siani L, Colloca S, Cottingham MG, Holder AA, Gilbert SC, Hill AV, Draper SJ. Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1. PLoS One. 2011; 6(6):e20977. PMID: 21698193; PMCID: PMC3116848.
    60. Ogun SA, Tewari R, Otto TD, Howell SA, Knuepfer E, Cunningham DA, Xu Z, Pain A, Holder AA. Targeted disruption of py235ebp-1: invasion of erythrocytes by Plasmodium yoelii using an alternative Py235 erythrocyte binding protein. PLoS Pathog. 2011 Feb; 7(2):e1001288. PMID: 21379566; PMCID: PMC3040676.
    61. Cook WJ, Smith CD, Senkovich O, Holder AA, Chattopadhyay D. Structure of Plasmodium falciparum ADP-ribosylation factor 1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 01; 66(Pt 11):1426-31. PMID: 21045287; PMCID: PMC3001640.
    62. Ngoundou-Landji J, Nwuba RI, Anumudu CI, Odaibo AB, Matondo Maya WD, Awobode HO, Okafor CM, Morenikeji OA, Asinobi A, Nwagwu M, Holder AA, Ntoumi F. Fine specificity of anti-MSP119 antibodies and multiplicity of Plasmodium falciparum merozoite surface protein 1 types in individuals in Nigeria with sub-microscopic infection. Malar J. 2010 Oct 18; 9:287. PMID: 20955565; PMCID: PMC2965716.
    63. Straschil U, Talman AM, Ferguson DJ, Bunting KA, Xu Z, Bailes E, Sinden RE, Holder AA, Smith EF, Coates JC. The Armadillo repeat protein PF16 is essential for flagellar structure and function in Plasmodium male gametes. PLoS One. 2010 Sep 23; 5(9):e12901. PMID: 20886115; PMCID: PMC2944832.
    64. Schmitz S, Schaap IA, Kleinjung J, Harder S, Grainger M, Calder L, Rosenthal PB, Holder AA, Veigel C. Malaria parasite actin polymerization and filament structure. J Biol Chem. 2010 Nov 19; 285(47):36577-85. PMID: 20826799; PMCID: PMC2978586.
    65. Goodman AL, Epp C, Moss D, Holder AA, Wilson JM, Gao GP, Long CA, Remarque EJ, Thomas AW, Ammendola V, Colloca S, Dicks MD, Biswas S, Seibel D, van Duivenvoorde LM, Gilbert SC, Hill AV, Draper SJ. New candidate vaccines against blood-stage Plasmodium falciparum malaria: prime-boost immunization regimens incorporating human and simian adenoviral vectors and poxviral vectors expressing an optimized antigen based on merozoite surface protein 1. Infect Immun. 2010 Nov; 78(11):4601-12. PMID: 20713623; PMCID: PMC2976338.
    66. Omosun YO, Adoro S, Anumudu CI, Odaibo A, Holder AA, Nwagwu M, Nwuba RI. Total immunoglobulin G and IgG1 subclass levels specific for the MSP-1(19) of Plasmodium falciparum are different in individuals with either processing-inhibitory, blocking or neutral antibodies. Afr Health Sci. 2010 Jun; 10(2):106-10. PMID: 21326959; PMCID: PMC2956298.
    67. Kadekoppala M, Ogun SA, Howell S, Gunaratne RS, Holder AA. Systematic genetic analysis of the Plasmodium falciparum MSP7-like family reveals differences in protein expression, location, and importance in asexual growth of the blood-stage parasite. Eukaryot Cell. 2010 Jul; 9(7):1064-74. PMID: 20472690; PMCID: PMC2901668.
    68. Kadekoppala M, Holder AA. Merozoite surface proteins of the malaria parasite: the MSP1 complex and the MSP7 family. Int J Parasitol. 2010 Aug 15; 40(10):1155-61. PMID: 20451527.
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    69. Eslava I, Payares G, Pernia BM, Holder AA, Spencer LM. Suppressive and additive effects in protection mediated by combinations of monoclonal antibodies specific for merozoite surface protein 1 of Plasmodium yoelii. Malar J. 2010 Feb 10; 9:46. PMID: 20146804; PMCID: PMC2834700.
    70. Thomas JC, Green JL, Howson RI, Simpson P, Moss DK, Martin SR, Holder AA, Cota E, Tate EW. Interaction and dynamics of the Plasmodium falciparum MTIP-MyoA complex, a key component of the invasion motor in the malaria parasite. Mol Biosyst. 2010 Mar; 6(3):494-8. PMID: 20174678.
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    71. Okafor CM, Anumudu CI, Omosun YO, Uthaipibull C, Ayede I, Awobode HO, Odaibo AB, Langhorne J, Holder AA, Nwuba RI, Troye-Blomberg M. Cellular responses to modified Plasmodium falciparum MSP119 antigens in individuals previously exposed to natural malaria infection. Malar J. 2009 Nov 23; 8:263. PMID: 19930613; PMCID: PMC2785830.
    72. Taylor HM, McRobert L, Grainger M, Sicard A, Dluzewski AR, Hopp CS, Holder AA, Baker DA. The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony. Eukaryot Cell. 2010 Jan; 9(1):37-45. PMID: 19915077; PMCID: PMC2805293.
    73. Holder AA. Malaria vaccines: where next? PLoS Pathog. 2009 Oct; 5(10):e1000638. PMID: 19876389; PMCID: PMC2763214.
    74. Craig AG, Holder AA, Leroy OY, Ventura RA. Malaria vaccines - how and when to proceed? Trends Parasitol. 2009 Dec; 25(12):535-7. PMID: 19837633.
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    75. Hinds L, Green JL, Knuepfer E, Grainger M, Holder AA. Novel putative glycosylphosphatidylinositol-anchored micronemal antigen of Plasmodium falciparum that binds to erythrocytes. Eukaryot Cell. 2009 Dec; 8(12):1869-79. PMID: 19820120; PMCID: PMC2794214.
    76. Lazarou M, Guevara Patiño JA, Jennings RM, McIntosh RS, Shi J, Howell S, Cullen E, Jones T, Adame-Gallegos JR, Chappel JA, McBride JS, Blackman MJ, Holder AA, Pleass RJ. Inhibition of erythrocyte invasion and Plasmodium falciparum merozoite surface protein 1 processing by human immunoglobulin G1 (IgG1) and IgG3 antibodies. Infect Immun. 2009 Dec; 77(12):5659-67. PMID: 19805526; PMCID: PMC2786472.
    77. Doerig C, Baker D, Billker O, Blackman MJ, Chitnis C, Dhar Kumar S, Heussler V, Holder AA, Kocken C, Krishna S, Langsley G, Lasonder E, Menard R, Meissner M, Pradel G, Ranford-Cartwright L, Sharma A, Sharma P, Tardieux T, Tatu U, Alano P. Signalling in malaria parasites. The MALSIG consortium. Parasite. 2009 Sep; 16(3):169-82. PMID: 19839262.
      View in: PubMed
    78. Bisseye C, van der Sande M, Morgan WD, Holder AA, Pinder M, Ismaili J. Plasmodium falciparum infection of the placenta impacts on the T helper type 1 (Th1)/Th2 balance of neonatal T cells through CD4(+)CD25(+) forkhead box P3(+) regulatory T cells and interleukin-10. Clin Exp Immunol. 2009 Dec; 158(3):287-93. PMID: 19758375; PMCID: PMC2792824.
    79. Holder AA. The carboxy-terminus of merozoite surface protein 1: structure, specific antibodies and immunity to malaria. Parasitology. 2009 Oct; 136(12):1445-56. PMID: 19627632.
      View in: PubMed
    80. Blythe JE, Niang M, Marsh K, Holder AA, Langhorne J, Preiser PR. Characterization of the repertoire diversity of the Plasmodium falciparum stevor multigene family in laboratory and field isolates. Malar J. 2009 Jun 26; 8:140. PMID: 19558642; PMCID: PMC2706845.
    81. Omosun YO, Adoro S, Anumudu CI, Odaibo AB, Uthiapibull C, Holder AA, Nwagwu M, Nwuba RI. Antibody specificities of children living in a malaria endemic area to inhibitory and blocking epitopes on MSP-1 19 of Plasmodium falciparum. Acta Trop. 2009 Mar; 109(3):208-12. PMID: 19081386.
      View in: PubMed
    82. Holder AA, Veigel C. Formin' an invasion machine: actin polymerization in invading apicomplexans. Trends Parasitol. 2009 Jan; 25(1):1-3. PMID: 18951846.
      View in: PubMed
    83. Kadekoppala M, O'Donnell RA, Grainger M, Crabb BS, Holder AA. Deletion of the Plasmodium falciparum merozoite surface protein 7 gene impairs parasite invasion of erythrocytes. Eukaryot Cell. 2008 Dec; 7(12):2123-32. PMID: 18820076; PMCID: PMC2593181.
    84. Green JL, Rees-Channer RR, Howell SA, Martin SR, Knuepfer E, Taylor HM, Grainger M, Holder AA. The motor complex of Plasmodium falciparum: phosphorylation by a calcium-dependent protein kinase. J Biol Chem. 2008 Nov 07; 283(45):30980-9. PMID: 18768477; PMCID: PMC2576532.
    85. Dluzewski AR, Ling IT, Hopkins JM, Grainger M, Margos G, Mitchell GH, Holder AA, Bannister LH. Formation of the food vacuole in Plasmodium falciparum: a potential role for the 19 kDa fragment of merozoite surface protein 1 (MSP1(19)). PLoS One. 2008 Aug 29; 3(8):e3085. PMID: 18769730; PMCID: PMC2518119.
    86. Narum DL, Nguyen V, Zhang Y, Glen J, Shimp RL, Lambert L, Ling IT, Reiter K, Ogun SA, Long C, Holder AA, Herrera R. Identification and characterization of the Plasmodium yoelii PyP140/RON4 protein, an orthologue of Toxoplasma gondii RON4, whose cysteine-rich domain does not protect against lethal parasite challenge infection. Infect Immun. 2008 Nov; 76(11):4876-82. PMID: 18710865; PMCID: PMC2573347.
    87. Draper SJ, Moore AC, Goodman AL, Long CA, Holder AA, Gilbert SC, Hill F, Hill AV. Effective induction of high-titer antibodies by viral vector vaccines. Nat Med. 2008 Aug; 14(8):819-21. PMID: 18660818; PMCID: PMC4822545.
    88. Arnot DE, Cavanagh DR, Remarque EJ, Creasey AM, Sowa MP, Morgan WD, Holder AA, Longacre S, Thomas AW. Comparative testing of six antigen-based malaria vaccine candidates directed toward merozoite-stage Plasmodium falciparum. Clin Vaccine Immunol. 2008 Sep; 15(9):1345-55. PMID: 18550731; PMCID: PMC2546674.
    89. Ogun SA, Dumon-Seignovert L, Marchand JB, Holder AA, Hill F. The oligomerization domain of C4-binding protein (C4bp) acts as an adjuvant, and the fusion protein comprised of the 19-kilodalton merozoite surface protein 1 fused with the murine C4bp domain protects mice against malaria. Infect Immun. 2008 Aug; 76(8):3817-23. PMID: 18474650; PMCID: PMC2493234.
    90. Blythe JE, Yam XY, Kuss C, Bozdech Z, Holder AA, Marsh K, Langhorne J, Preiser PR. Plasmodium falciparum STEVOR proteins are highly expressed in patient isolates and located in the surface membranes of infected red blood cells and the apical tips of merozoites. Infect Immun. 2008 Jul; 76(7):3329-36. PMID: 18474651; PMCID: PMC2446718.
    91. Bowyer PW, Tate EW, Leatherbarrow RJ, Holder AA, Smith DF, Brown KA. N-myristoyltransferase: a prospective drug target for protozoan parasites. ChemMedChem. 2008 Mar; 3(3):402-8. PMID: 18324715.
      View in: PubMed
    92. Vivas L, O'Dea KP, Noya O, Pabon R, Magris M, Botto C, Holder AA, Brown KN. Hyperreactive malarial splenomegaly is associated with low levels of antibodies against red blood cell and Plasmodium falciparum derived glycolipids in Yanomami Amerindians from Venezuela. Acta Trop. 2008 Mar; 105(3):207-14. PMID: 18243148.
      View in: PubMed
    93. Bowyer PW, Gunaratne RS, Grainger M, Withers-Martinez C, Wickramsinghe SR, Tate EW, Leatherbarrow RJ, Brown KA, Holder AA, Smith DF. Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum. Biochem J. 2007 Dec 01; 408(2):173-80. PMID: 17714074; PMCID: PMC2267354.
    94. Heal WP, Wickramasinghe SR, Bowyer PW, Holder AA, Smith DF, Leatherbarrow RJ, Tate EW. Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry. Chem Commun (Camb). 2008 Jan 28; (4):480-2. PMID: 18188474.
      View in: PubMed
    95. Faber BW, Remarque EJ, Morgan WD, Kocken CH, Holder AA, Thomas AW. Malaria vaccine-related benefits of a single protein comprising Plasmodium falciparum apical membrane antigen 1 domains I and II fused to a modified form of the 19-kilodalton C-terminal fragment of merozoite surface protein 1. Infect Immun. 2007 Dec; 75(12):5947-55. PMID: 17938224; PMCID: PMC2168333.
    96. Cortés A, Carret C, Kaneko O, Yim Lim BY, Ivens A, Holder AA. Epigenetic silencing of Plasmodium falciparum genes linked to erythrocyte invasion. PLoS Pathog. 2007 Aug 03; 3(8):e107. PMID: 17676953; PMCID: PMC1937010.
    97. McIntosh RS, Shi J, Jennings RM, Chappel JC, de Koning-Ward TF, Smith T, Green J, van Egmond M, Leusen JH, Lazarou M, van de Winkel J, Jones TS, Crabb BS, Holder AA, Pleass RJ. The importance of human FcgammaRI in mediating protection to malaria. PLoS Pathog. 2007 May 18; 3(5):e72. PMID: 17511516; PMCID: PMC1868954.
    98. Gray JC, Corran PH, Mangia E, Gaunt MW, Li Q, Tetteh KK, Polley SD, Conway DJ, Holder AA, Bacarese-Hamilton T, Riley EM, Crisanti A. Profiling the antibody immune response against blood stage malaria vaccine candidates. Clin Chem. 2007 Jul; 53(7):1244-53. PMID: 17510307.
      View in: PubMed
    99. Babon JJ, Morgan WD, Kelly G, Eccleston JF, Feeney J, Holder AA. Structural studies on Plasmodium vivax merozoite surface protein-1. Mol Biochem Parasitol. 2007 May; 153(1):31-40. PMID: 17343930.
      View in: PubMed
    100. Pachebat JA, Kadekoppala M, Grainger M, Dluzewski AR, Gunaratne RS, Scott-Finnigan TJ, Ogun SA, Ling IT, Bannister LH, Taylor HM, Mitchell GH, Holder AA. Extensive proteolytic processing of the malaria parasite merozoite surface protein 7 during biosynthesis and parasite release from erythrocytes. Mol Biochem Parasitol. 2007 Jan; 151(1):59-69. PMID: 17097159.
      View in: PubMed
    101. Narum DL, Ogun SA, Batchelor AH, Holder AA. Passive immunization with a multicomponent vaccine against conserved domains of apical membrane antigen 1 and 235-kilodalton rhoptry proteins protects mice against Plasmodium yoelii blood-stage challenge infection. Infect Immun. 2006 Oct; 74(10):5529-36. PMID: 16988228; PMCID: PMC1594904.
    102. Green JL, Hinds L, Grainger M, Knuepfer E, Holder AA. Plasmodium thrombospondin related apical merozoite protein (PTRAMP) is shed from the surface of merozoites by PfSUB2 upon invasion of erythrocytes. Mol Biochem Parasitol. 2006 Nov; 150(1):114-7. PMID: 16879884.
      View in: PubMed
    103. Rees-Channer RR, Martin SR, Green JL, Bowyer PW, Grainger M, Molloy JE, Holder AA. Dual acylation of the 45 kDa gliding-associated protein (GAP45) in Plasmodium falciparum merozoites. Mol Biochem Parasitol. 2006 Sep; 149(1):113-6. PMID: 16750579.
      View in: PubMed
    104. Pinder M, Sutherland CJ, Sisay-Joof F, Ismaili J, McCall MB, Ord R, Hallett R, Holder AA, Milligan P. Immunoglobulin G antibodies to merozoite surface antigens are associated with recovery from chloroquine-resistant Plasmodium falciparum in Gambian children. Infect Immun. 2006 May; 74(5):2887-93. PMID: 16622227; PMCID: PMC1459689.
    105. Ogun SA, Howell SA, Taylor HM, Holder AA. A member of the py235 gene family of Plasmodium yoelii encodes an erythrocyte binding protein recognised by a protective monoclonal antibody. Mol Biochem Parasitol. 2006 May; 147(1):140-3. PMID: 16516987.
      View in: PubMed
    106. Baum J, Richard D, Healer J, Rug M, Krnajski Z, Gilberger TW, Green JL, Holder AA, Cowman AF. A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites. J Biol Chem. 2006 Feb 24; 281(8):5197-208. PMID: 16321976.
      View in: PubMed
    107. Green JL, Martin SR, Fielden J, Ksagoni A, Grainger M, Yim Lim BY, Molloy JE, Holder AA. The MTIP-myosin A complex in blood stage malaria parasites. J Mol Biol. 2006 Feb 03; 355(5):933-41. PMID: 16337961.
      View in: PubMed
    108. Pleass RJ, Holder AA. Opinion: antibody-based therapies for malaria. Nat Rev Microbiol. 2005 Nov; 3(11):893-9. PMID: 16261172.
      View in: PubMed
    109. Kaneko O, Yim Lim BY, Iriko H, Ling IT, Otsuki H, Grainger M, Tsuboi T, Adams JH, Mattei D, Holder AA, Torii M. Apical expression of three RhopH1/Clag proteins as components of the Plasmodium falciparum RhopH complex. Mol Biochem Parasitol. 2005 Sep; 143(1):20-8. PMID: 15953647.
      View in: PubMed
    110. Omosun YO, Anumudu CI, Adoro S, Odaibo AB, Sodeinde O, Holder AA, Nwagwu M, Nwuba RI. Variation in the relationship between anti-MSP-1(19) antibody response and age in children infected with Plasmodium falciparum during the dry and rainy seasons. Acta Trop. 2005 Sep; 95(3):233-47. PMID: 16055071.
      View in: PubMed
    111. Schmitz S, Grainger M, Howell S, Calder LJ, Gaeb M, Pinder JC, Holder AA, Veigel C. Malaria parasite actin filaments are very short. J Mol Biol. 2005 May 27; 349(1):113-25. PMID: 15876372.
      View in: PubMed
    112. O'Keeffe AH, Green JL, Grainger M, Holder AA. A novel Sushi domain-containing protein of Plasmodium falciparum. Mol Biochem Parasitol. 2005 Mar; 140(1):61-8. PMID: 15694487.
      View in: PubMed
    113. Morgan WD, Frenkiel TA, Lock MJ, Grainger M, Holder AA. Precise epitope mapping of malaria parasite inhibitory antibodies by TROSY NMR cross-saturation. Biochemistry. 2005 Jan 18; 44(2):518-23. PMID: 15641776.
      View in: PubMed
    114. Darko CA, Angov E, Collins WE, Bergmann-Leitner ES, Girouard AS, Hitt SL, McBride JS, Diggs CL, Holder AA, Long CA, Barnwell JW, Lyon JA. The clinical-grade 42-kilodalton fragment of merozoite surface protein 1 of Plasmodium falciparum strain FVO expressed in Escherichia coli protects Aotus nancymai against challenge with homologous erythrocytic-stage parasites. Infect Immun. 2005 Jan; 73(1):287-97. PMID: 15618165; PMCID: PMC538964.
    115. Le Roch KG, Johnson JR, Florens L, Zhou Y, Santrosyan A, Grainger M, Yan SF, Williamson KC, Holder AA, Carucci DJ, Yates JR, Winzeler EA. Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. Genome Res. 2004 Nov; 14(11):2308-18. PMID: 15520293; PMCID: PMC525690.
    116. Morgan WD, Lock MJ, Frenkiel TA, Grainger M, Holder AA. Malaria parasite-inhibitory antibody epitopes on Plasmodium falciparum merozoite surface protein-1(19) mapped by TROSY NMR. Mol Biochem Parasitol. 2004 Nov; 138(1):29-36. PMID: 15500913.
      View in: PubMed
    117. Corran PH, O'Donnell RA, Todd J, Uthaipibull C, Holder AA, Crabb BS, Riley EM. The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in The Gambia. Infect Immun. 2004 Oct; 72(10):6185-9. PMID: 15385530; PMCID: PMC517553.
    118. Goschnick MW, Black CG, Kedzierski L, Holder AA, Coppel RL. Merozoite surface protein 4/5 provides protection against lethal challenge with a heterologous malaria parasite strain. Infect Immun. 2004 Oct; 72(10):5840-9. PMID: 15385485; PMCID: PMC517552.
    119. Dekker C, Uthaipibull C, Calder LJ, Lock M, Grainger M, Morgan WD, Dodson GG, Holder AA. Inhibitory and neutral antibodies to Plasmodium falciparum MSP119 form ring structures with their antigen. Mol Biochem Parasitol. 2004 Sep; 137(1):143-9. PMID: 15279960.
      View in: PubMed
    120. Tewari R, Ogun SA, Gunaratne RS, Crisanti A, Holder AA. Disruption of Plasmodium berghei merozoite surface protein 7 gene modulates parasite growth in vivo. Blood. 2005 Jan 01; 105(1):394-6. PMID: 15339842.
      View in: PubMed
    121. Lucas SJ, Holder AA. An improved chloramphenicol acetyltransferase assay for Plasmodium falciparum transfection. Mol Biochem Parasitol. 2004 Aug; 136(2):287-96. PMID: 15478807.
      View in: PubMed
    122. Ling IT, Florens L, Dluzewski AR, Kaneko O, Grainger M, Yim Lim BY, Tsuboi T, Hopkins JM, Johnson JR, Torii M, Bannister LH, Yates JR, Holder AA, Mattei D. The Plasmodium falciparum clag9 gene encodes a rhoptry protein that is transferred to the host erythrocyte upon invasion. Mol Microbiol. 2004 Apr; 52(1):107-18. PMID: 15049814.
      View in: PubMed
    123. Okech BA, Corran PH, Todd J, Joynson-Hicks A, Uthaipibull C, Egwang TG, Holder AA, Riley EM. Fine specificity of serum antibodies to Plasmodium falciparum merozoite surface protein, PfMSP-1(19), predicts protection from malaria infection and high-density parasitemia. Infect Immun. 2004 Mar; 72(3):1557-67. PMID: 14977962; PMCID: PMC356041.
    124. Hensmann M, Li C, Moss C, Lindo V, Greer F, Watts C, Ogun SA, Holder AA, Langhorne J. Disulfide bonds in merozoite surface protein 1 of the malaria parasite impede efficient antigen processing and affect the in vivo antibody response. Eur J Immunol. 2004 Mar; 34(3):639-648. PMID: 14991593.
      View in: PubMed
    125. Fleck SL, Birdsall B, Babon J, Dluzewski AR, Martin SR, Morgan WD, Angov E, Kettleborough CA, Feeney J, Blackman MJ, Holder AA. Suramin and suramin analogues inhibit merozoite surface protein-1 secondary processing and erythrocyte invasion by the malaria parasite Plasmodium falciparum. J Biol Chem. 2003 Nov 28; 278(48):47670-7. PMID: 13679371.
      View in: PubMed
    126. Hiller NL, Akompong T, Morrow JS, Holder AA, Haldar K. Identification of a stomatin orthologue in vacuoles induced in human erythrocytes by malaria parasites. A role for microbial raft proteins in apicomplexan vacuole biogenesis. J Biol Chem. 2003 Nov 28; 278(48):48413-21. PMID: 12968029.
      View in: PubMed
    127. Le Roch KG, Zhou Y, Blair PL, Grainger M, Moch JK, Haynes JD, De La Vega P, Holder AA, Batalov S, Carucci DJ, Winzeler EA. Discovery of gene function by expression profiling of the malaria parasite life cycle. Science. 2003 Sep 12; 301(5639):1503-8. PMID: 12893887.
      View in: PubMed
    128. Pleass RJ, Ogun SA, McGuinness DH, van de Winkel JG, Holder AA, Woof JM. Novel antimalarial antibodies highlight the importance of the antibody Fc region in mediating protection. Blood. 2003 Dec 15; 102(13):4424-30. PMID: 12855589.
      View in: PubMed
    129. Kimmel J, Ogun SA, de Macedo CS, Gerold P, Vivas L, Holder AA, Schwarz RT, Azzouz N. Glycosylphosphatidyl-inositols in murine malaria: Plasmodium yoelii yoelii. Biochimie. 2003 Mar-Apr; 85(3-4):473-81. PMID: 12770786.
      View in: PubMed
    130. Ling IT, Kaneko O, Narum DL, Tsuboi T, Howell S, Taylor HM, Scott-Finnigan TJ, Torii M, Holder AA. Characterisation of the rhoph2 gene of Plasmodium falciparum and Plasmodium yoelii. Mol Biochem Parasitol. 2003 Mar; 127(1):47-57. PMID: 12615335.
      View in: PubMed
    131. Greenbaum DC, Baruch A, Grainger M, Bozdech Z, Medzihradszky KF, Engel J, DeRisi J, Holder AA, Bogyo M. A role for the protease falcipain 1 in host cell invasion by the human malaria parasite. Science. 2002 Dec 06; 298(5600):2002-6. PMID: 12471262.
      View in: PubMed
    132. Fievet N, Tami G, Maubert B, Moussa M, Shaw IK, Cot M, Holder AA, Chaouat G, Deloron P. Cellular immune response to Plasmodium falciparum after pregnancy is related to previous placental infection and parity. Malar J. 2002 Nov 26; 1:16. PMID: 12495437; PMCID: PMC149387.
    133. Florens L, Washburn MP, Raine JD, Anthony RM, Grainger M, Haynes JD, Moch JK, Muster N, Sacci JB, Tabb DL, Witney AA, Wolters D, Wu Y, Gardner MJ, Holder AA, Sinden RE, Yates JR, Carucci DJ. A proteomic view of the Plasmodium falciparum life cycle. Nature. 2002 Oct 03; 419(6906):520-6. PMID: 12368866.
      View in: PubMed
    134. Taylor HM, Grainger M, Holder AA. Variation in the expression of a Plasmodium falciparum protein family implicated in erythrocyte invasion. Infect Immun. 2002 Oct; 70(10):5779-89. PMID: 12228308; PMCID: PMC128319.
    135. Tewari R, Spaccapelo R, Bistoni F, Holder AA, Crisanti A. Function of region I and II adhesive motifs of Plasmodium falciparum circumsporozoite protein in sporozoite motility and infectivity. J Biol Chem. 2002 Dec 06; 277(49):47613-8. PMID: 12244064.
      View in: PubMed
    136. Nwuba RI, Sodeinde O, Anumudu CI, Omosun YO, Odaibo AB, Holder AA, Nwagwu M. The human immune response to Plasmodium falciparum includes both antibodies that inhibit merozoite surface protein 1 secondary processing and blocking antibodies. Infect Immun. 2002 Sep; 70(9):5328-31. PMID: 12183594; PMCID: PMC128297.
    137. Delrieu I, Waller CC, Mota MM, Grainger M, Langhorne J, Holder AA. PSLAP, a protein with multiple adhesive motifs, is expressed in Plasmodium falciparum gametocytes. Mol Biochem Parasitol. 2002 Apr 30; 121(1):11-20. PMID: 11985859.
      View in: PubMed
    138. Ahlborg N, Ling IT, Howard W, Holder AA, Riley EM. Protective immune responses to the 42-kilodalton (kDa) region of Plasmodium yoelii merozoite surface protein 1 are induced by the C-terminal 19-kDa region but not by the adjacent 33-kDa region. Infect Immun. 2002 Feb; 70(2):820-5. PMID: 11796616; PMCID: PMC127676.
    139. Preiser PR, Khan S, Costa FT, Jarra W, Belnoue E, Ogun S, Holder AA, Voza T, Landau I, Snounou G, Rénia L. Stage-specific transcription of distinct repertoires of a multigene family during Plasmodium life cycle. Science. 2002 Jan 11; 295(5553):342-5. PMID: 11786645.
      View in: PubMed
    140. Kaneko O, Tsuboi T, Ling IT, Howell S, Shirano M, Tachibana M, Cao YM, Holder AA, Torii M. The high molecular mass rhoptry protein, RhopH1, is encoded by members of the clag multigene family in Plasmodium falciparum and Plasmodium yoelii. Mol Biochem Parasitol. 2001 Dec; 118(2):223-31. PMID: 11738712.
      View in: PubMed
    141. Pachebat JA, Ling IT, Grainger M, Trucco C, Howell S, Fernandez-Reyes D, Gunaratne R, Holder AA. The 22 kDa component of the protein complex on the surface of Plasmodium falciparum merozoites is derived from a larger precursor, merozoite surface protein 7. Mol Biochem Parasitol. 2001 Sep 28; 117(1):83-9. PMID: 11551634.
      View in: PubMed
    142. Taylor HM, Triglia T, Thompson J, Sajid M, Fowler R, Wickham ME, Cowman AF, Holder AA. Plasmodium falciparum homologue of the genes for Plasmodium vivax and Plasmodium yoelii adhesive proteins, which is transcribed but not translated. Infect Immun. 2001 Jun; 69(6):3635-45. PMID: 11349024; PMCID: PMC98354.
    143. Uthaipibull C, Aufiero B, Syed SE, Hansen B, Guevara Patiño JA, Angov E, Ling IT, Fegeding K, Morgan WD, Ockenhouse C, Birdsall B, Feeney J, Lyon JA, Holder AA. Inhibitory and blocking monoclonal antibody epitopes on merozoite surface protein 1 of the malaria parasite Plasmodium falciparum. J Mol Biol. 2001 Apr 13; 307(5):1381-94. PMID: 11292349.
      View in: PubMed
    144. Mota MM, Brown KN, Do Rosário VE, Holder AA, Jarra W. Antibody recognition of rodent malaria parasite antigens exposed at the infected erythrocyte surface: specificity of immunity generated in hyperimmune mice. Infect Immun. 2001 Apr; 69(4):2535-41. PMID: 11254617; PMCID: PMC98189.
    145. Narum DL, Green JL, Ogun SA, Holder AA. Sequence diversity and antigenic polymorphism in the Plasmodium yoelii p235 high molecular mass rhoptry proteins and their genes. Mol Biochem Parasitol. 2001 Feb; 112(2):193-200. PMID: 11223126.
      View in: PubMed
    146. Trucco C, Fernandez-Reyes D, Howell S, Stafford WH, Scott-Finnigan TJ, Grainger M, Ogun SA, Taylor WR, Holder AA. The merozoite surface protein 6 gene codes for a 36 kDa protein associated with the Plasmodium falciparum merozoite surface protein-1 complex. Mol Biochem Parasitol. 2001 Jan 15; 112(1):91-101. PMID: 11166390.
      View in: PubMed
    147. Wu S, Beier M, Sztein MB, Galen J, Pickett T, Holder AA, Gómez-Duarte OG, Levine MM. Construction and immunogenicity in mice of attenuated Salmonella typhi expressing Plasmodium falciparum merozoite surface protein 1 (MSP-1) fused to tetanus toxin fragment C. J Biotechnol. 2000 Sep 29; 83(1-2):125-35. PMID: 11000468.
      View in: PubMed
    148. Green JL, Holder AA. Structure of the E8 gene encoding a high molecular mass rhoptry protein of Plasmodium yoelii. Mol Biochem Parasitol. 2000 Sep; 110(1):167-9. PMID: 10989154.
      View in: PubMed
    149. Mota MM, Jarra W, Hirst E, Patnaik PK, Holder AA. Plasmodium chabaudi-infected erythrocytes adhere to CD36 and bind to microvascular endothelial cells in an organ-specific way. Infect Immun. 2000 Jul; 68(7):4135-44. PMID: 10858230; PMCID: PMC101711.
    150. Ogun SA, Scott-Finnigan TJ, Narum DL, Holder AA. Plasmodium yoelii: effects of red blood cell modification and antibodies on the binding characteristics of the 235-kDa rhoptry protein. Exp Parasitol. 2000 Jul; 95(3):187-95. PMID: 10964646.
      View in: PubMed
    151. Gunaratne RS, Sajid M, Ling IT, Tripathi R, Pachebat JA, Holder AA. Characterization of N-myristoyltransferase from Plasmodium falciparum. Biochem J. 2000 Jun 01; 348 Pt 2:459-63. PMID: 10816442; PMCID: PMC1221086.
    152. Narum DL, Ogun SA, Thomas AW, Holder AA. Immunization with parasite-derived apical membrane antigen 1 or passive immunization with a specific monoclonal antibody protects BALB/c mice against lethal Plasmodium yoelii yoelii YM blood-stage infection. Infect Immun. 2000 May; 68(5):2899-906. PMID: 10768987; PMCID: PMC97502.
    153. Ahlborg N, Ling IT, Holder AA, Riley EM. Linkage of exogenous T-cell epitopes to the 19-kilodalton region of Plasmodium yoelii merozoite surface protein 1 (MSP1(19)) can enhance protective immunity against malaria and modulate the immunoglobulin subclass response to MSP1(19). Infect Immun. 2000 Apr; 68(4):2102-9. PMID: 10722607; PMCID: PMC97391.
    154. Berhe S, Gerold P, Kedees MH, Holder AA, Schwarz RT. Plasmodium falciparum: merozoite surface proteins 1 and 2 are not posttranslationally modified by classical N- or O-glycans. Exp Parasitol. 2000 Mar; 94(3):194-7. PMID: 10831385.
      View in: PubMed
    155. Kedees MH, Gerold P, Azzouz N, Blaschke T, Shams-Eldin H, Mühlberger E, Holder AA, Klenk HD, Schwarz RT, Eckert V. Processing and localisation of a GPI-anchored Plasmodium falciparum surface protein expressed by the baculovirus system. Eur J Cell Biol. 2000 Jan; 79(1):52-61. PMID: 10711426.
      View in: PubMed
    156. Benjamin PA, Ling IT, Clottey G, Valero LM, Ogun SA, Fleck SL, Walliker D, Morgan WD, Birdsall B, Feeney J, Holder AA. Antigenic and sequence diversity at the C-terminus of the merozoite surface protein-1 from rodent malaria isolates, and the binding of protective monoclonal antibodies. Mol Biochem Parasitol. 1999 Nov 30; 104(2):147-56. PMID: 10593171.
      View in: PubMed
    157. Holder AA, Guevara Patiño JA, Uthaipibull C, Syed SE, Ling IT, Scott-Finnigan T, Blackman MJ. Merozoite surface protein 1, immune evasion, and vaccines against asexual blood stage malaria. Parassitologia. 1999 Sep; 41(1-3):409-14. PMID: 10697894.
      View in: PubMed
    158. Morgan WD, Birdsall B, Frenkiel TA, Gradwell MG, Burghaus PA, Syed SE, Uthaipibull C, Holder AA, Feeney J. Solution structure of an EGF module pair from the Plasmodium falciparum merozoite surface protein 1. J Mol Biol. 1999 May 28; 289(1):113-22. PMID: 10339410.
      View in: PubMed
    159. Owen CA, Sinha KA, Keen JK, Ogun SA, Holder AA. Chromosomal organisation of a gene family encoding rhoptry proteins in Plasmodium yoelii. Mol Biochem Parasitol. 1999 Apr 30; 99(2):183-92. PMID: 10340483.
      View in: PubMed
    160. Garraud O, Diouf A, Nguer CM, Dieye A, Longacre S, Kaslow DC, Holder AA, Tall A, Molez JF, Perraut R, Mercereau-Puijalon O. Different Plasmodium falciparum recombinant MSP1(19) antigens differ in their capacities to stimulate in vitro peripheral blood T lymphocytes in individuals from various endemic areas. Scand J Immunol. 1999 Apr; 49(4):431-40. PMID: 10219771.
      View in: PubMed
    161. Egan AF, Burghaus P, Druilhe P, Holder AA, Riley EM. Human antibodies to the 19kDa C-terminal fragment of Plasmodium falciparum merozoite surface protein 1 inhibit parasite growth in vitro. Parasite Immunol. 1999 Mar; 21(3):133-9. PMID: 10205793.
      View in: PubMed
    162. Holder AA. Malaria vaccines. Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1167-9. PMID: 9989994; PMCID: PMC33549.
    163. Somner EA, Ogun SA, Sinha KA, Spencer Valero LM, Lee JJ, Harrison JA, Holder AA, Hormaeche CE, Khan CM. Expression of disulphide-bridge-dependent conformational epitopes and immunogenicity of the carboxy-terminal 19 kDa domain of Plasmodium yoelii merozoite surface protein-1 in live attenuated Salmonella vaccine strains. Microbiology. 1999 Jan; 145 ( Pt 1):221-9. PMID: 10206702.
      View in: PubMed
    164. Mota MM, Brown KN, Holder AA, Jarra W. Acute Plasmodium chabaudi chabaudi malaria infection induces antibodies which bind to the surfaces of parasitized erythrocytes and promote their phagocytosis by macrophages in vitro. Infect Immun. 1998 Sep; 66(9):4080-6. PMID: 9712751; PMCID: PMC108489.
    165. Werner EB, Taylor WR, Holder AA. A Plasmodium chabaudi protein contains a repetitive region with a predicted spectrin-like structure. Mol Biochem Parasitol. 1998 Aug 01; 94(2):185-96. PMID: 9747969.
      View in: PubMed
    166. Spencer Valero LM, Ogun SA, Fleck SL, Ling IT, Scott-Finnigan TJ, Blackman MJ, Holder AA. Passive immunization with antibodies against three distinct epitopes on Plasmodium yoelii merozoite surface protein 1 suppresses parasitemia. Infect Immun. 1998 Aug; 66(8):3925-30. PMID: 9673281; PMCID: PMC108453.
    167. Cavanagh DR, Elhassan IM, Roper C, Robinson VJ, Giha H, Holder AA, Hviid L, Theander TG, Arnot DE, McBride JS. A longitudinal study of type-specific antibody responses to Plasmodium falciparum merozoite surface protein-1 in an area of unstable malaria in Sudan. J Immunol. 1998 Jul 01; 161(1):347-59. PMID: 9647243.
      View in: PubMed
    168. Tian JH, Good MF, Hirunpetcharat C, Kumar S, Ling IT, Jackson D, Cooper J, Lukszo J, Coligan J, Ahlers J, Saul A, Berzofsky JA, Holder AA, Miller LH, Kaslow DC. Definition of T cell epitopes within the 19 kDa carboxylterminal fragment of Plasmodium yoelii merozoite surface protein 1 (MSP1(19)) and their role in immunity to malaria. Parasite Immunol. 1998 Jun; 20(6):263-78. PMID: 9651928.
      View in: PubMed
    169. Gerold P, Vivas L, Ogun SA, Azzouz N, Brown KN, Holder AA, Schwarz RT. Glycosylphosphatidylinositols of Plasmodium chabaudi chabaudi: a basis for the study of malarial glycolipid toxins in a rodent model. Biochem J. 1997 Dec 15; 328 ( Pt 3):905-11. PMID: 9396737; PMCID: PMC1219003.
    170. Guevara Patiño JA, Holder AA, McBride JS, Blackman MJ. Antibodies that inhibit malaria merozoite surface protein-1 processing and erythrocyte invasion are blocked by naturally acquired human antibodies. J Exp Med. 1997 Nov 17; 186(10):1689-99. PMID: 9362529; PMCID: PMC2199131.
    171. Rénia L, Ling IT, Marussig M, Miltgen F, Holder AA, Mazier D. Immunization with a recombinant C-terminal fragment of Plasmodium yoelii merozoite surface protein 1 protects mice against homologous but not heterologous P. yoelii sporozoite challenge. Infect Immun. 1997 Nov; 65(11):4419-23. PMID: 9353014; PMCID: PMC175635.
    172. Ling IT, Ogun SA, Momin P, Richards RL, Garçon N, Cohen J, Ballou WR, Holder AA. Immunization against the murine malaria parasite Plasmodium yoelii using a recombinant protein with adjuvants developed for clinical use. Vaccine. 1997 Oct; 15(14):1562-7. PMID: 9330469.
      View in: PubMed
    173. Egan A, Waterfall M, Pinder M, Holder A, Riley E. Characterization of human T- and B-cell epitopes in the C terminus of Plasmodium falciparum merozoite surface protein 1: evidence for poor T-cell recognition of polypeptides with numerous disulfide bonds. Infect Immun. 1997 Aug; 65(8):3024-31. PMID: 9234749; PMCID: PMC175426.
    174. Werner E, Patel K, Holder AA. Construction of a library for sequencing long regions of malarial genomic DNA. Biotechniques. 1997 Jul; 23(1):20, 22, 24. PMID: 9232219.
      View in: PubMed
    175. Longhurst HJ, Holder AA. The histones of Plasmodium falciparum: identification, purification and a possible role in the pathology of malaria. Parasitology. 1997 May; 114 ( Pt 5):413-9. PMID: 9149412.
      View in: PubMed
    176. Werner E, Holder AA, Hoheisel JD. Growth and storage of YAC clones in Hogness Freezing Medium. Nucleic Acids Res. 1997 Apr 01; 25(7):1467-8. PMID: 9060445; PMCID: PMC146591.
    177. Seesod N, Nopparat P, Hedrum A, Holder A, Thaithong S, Uhlen M, Lundeberg J. An integrated system using immunomagnetic separation, polymerase chain reaction, and colorimetric detection for diagnosis of Plasmodium falciparum. Am J Trop Med Hyg. 1997 Mar; 56(3):322-8. PMID: 9129537.
      View in: PubMed
    178. Zinecker CF, Gerold P, Azzouz N, Striepen B, Schmidt A, Berhe S, Kimmel J, Keddes MH, Blackman MJ, Schofield L, Ogun S, Damm JB, Melgers PA, Koolen M, Gerwig GJ, Vliegenhardt JF, Dubremetz JF, Holder AA, Eckert V, Capdeville Y, Tachado SD, Schwarz RT. Glycosyl-phosphatidylinositols in protozoa structure, biosynthesis and intracellular localisation. Indian J Biochem Biophys. 1997 Feb-Apr; 34(1-2):105-9. PMID: 9343937.
      View in: PubMed
    179. Stafford WH, Stockley RW, Ludbrook SB, Holder AA. Isolation, expression and characterization of the gene for an ADP-ribosylation factor from the human malaria parasite, Plasmodium falciparum. Eur J Biochem. 1996 Nov 15; 242(1):104-13. PMID: 8954160.
      View in: PubMed
    180. Stafford WH, Günder B, Harris A, Heidrich HG, Holder AA, Blackman MJ. A 22 kDa protein associated with the Plasmodium falciparum merozoite surface protein-1 complex. Mol Biochem Parasitol. 1996 Oct 01; 80(2):159-69. PMID: 8892293.
      View in: PubMed
    181. Burghaus PA, Wellde BT, Hall T, Richards RL, Egan AF, Riley EM, Ballou WR, Holder AA. Immunization of Aotus nancymai with recombinant C terminus of Plasmodium falciparum merozoite surface protein 1 in liposomes and alum adjuvant does not induce protection against a challenge infection. Infect Immun. 1996 Sep; 64(9):3614-9. PMID: 8751907; PMCID: PMC174271.
    182. De Souza JB, Ling IT, Ogun SA, Holder AA, Playfair JH. Cytokines and antibody subclass associated with protective immunity against blood-stage malaria in mice vaccinated with the C terminus of merozoite surface protein 1 plus a novel adjuvant. Infect Immun. 1996 Sep; 64(9):3532-6. PMID: 8751895; PMCID: PMC174259.
    183. Dame JB, Arnot DE, Bourke PF, Chakrabarti D, Christodoulou Z, Coppel RL, Cowman AF, Craig AG, Fischer K, Foster J, Goodman N, Hinterberg K, Holder AA, Holt DC, Kemp DJ, Lanzer M, Lim A, Newbold CI, Ravetch JV, Reddy GR, Rubio J, Schuster SM, Su XZ, Thompson JK, Werner EB, et al. Current status of the Plasmodium falciparum genome project. Mol Biochem Parasitol. 1996 Jul; 79(1):1-12. PMID: 8844667.
      View in: PubMed
    184. Holder AA, Riley EM. Human immune response to MSP-1. Parasitol Today. 1996 May; 12(5):173-4; discussion 206. PMID: 15275209.
      View in: PubMed
    185. Egan AF, Morris J, Barnish G, Allen S, Greenwood BM, Kaslow DC, Holder AA, Riley EM. Clinical immunity to Plasmodium falciparum malaria is associated with serum antibodies to the 19-kDa C-terminal fragment of the merozoite surface antigen, PfMSP-1. J Infect Dis. 1996 Mar; 173(3):765-9. PMID: 8627050.
      View in: PubMed
    186. Ogun SA, Holder AA. A high molecular mass Plasmodium yoelii rhoptry protein binds to erythrocytes. Mol Biochem Parasitol. 1996 Feb-Mar; 76(1-2):321-4. PMID: 8920020.
      View in: PubMed
    187. Sinha KA, Keen JK, Ogun SA, Holder AA. Comparison of two members of a multigene family coding for high-molecular mass rhoptry proteins of Plasmodium yoelii. Mol Biochem Parasitol. 1996 Feb-Mar; 76(1-2):329-32. PMID: 8920022.
      View in: PubMed
    188. Gerold P, Schofield L, Blackman MJ, Holder AA, Schwarz RT. Structural analysis of the glycosyl-phosphatidylinositol membrane anchor of the merozoite surface proteins-1 and -2 of Plasmodium falciparum. Mol Biochem Parasitol. 1996 Jan; 75(2):131-43. PMID: 8992312.
      View in: PubMed
    189. Ling IT, Ogun SA, Holder AA. The combined epidermal growth factor-like modules of Plasmodium yoelii Merozoite Surface Protein-1 are required for a protective immune response to the parasite. Parasite Immunol. 1995 Aug; 17(8):425-33. PMID: 7501423.
      View in: PubMed
    190. Abath FG, Holder AA. A strategy to sequence repetitive DNA based on partial restriction enzyme cleavage. Appl Biochem Biotechnol. 1995 Jun; 53(3):195-7. PMID: 7605117.
      View in: PubMed
    191. Shai S, Blackman MJ, Holder AA. Epitopes in the 19kDa fragment of the Plasmodium falciparum major merozoite surface protein-1 (PfMSP-1(19)) recognized by human antibodies. Parasite Immunol. 1995 May; 17(5):269-75. PMID: 7545808.
      View in: PubMed
    192. Borre MB, Owen CA, Keen JK, Sinha KA, Holder AA. Multiple genes code for high-molecular-mass rhoptry proteins of Plasmodium yoelii. Mol Biochem Parasitol. 1995 Mar; 70(1-2):149-55. PMID: 7637695.
      View in: PubMed
    193. Sinclair AJ, Palmero I, Holder A, Peters G, Farrell PJ. Expression of cyclin D2 in Epstein-Barr virus-positive Burkitt's lymphoma cell lines is related to methylation status of the gene. J Virol. 1995 Feb; 69(2):1292-5. PMID: 7529333; PMCID: PMC188707.
    194. Egan AF, Chappel JA, Burghaus PA, Morris JS, McBride JS, Holder AA, Kaslow DC, Riley EM. Serum antibodies from malaria-exposed people recognize conserved epitopes formed by the two epidermal growth factor motifs of MSP1(19), the carboxy-terminal fragment of the major merozoite surface protein of Plasmodium falciparum. Infect Immun. 1995 Feb; 63(2):456-66. PMID: 7822010; PMCID: PMC173017.
    195. Longhurst HJ, Holder AA. The sequence of Plasmodium falciparum histone H3. Mol Biochem Parasitol. 1995 Jan; 69(1):111-3. PMID: 7723778.
      View in: PubMed
    196. Ogun SA, Holder AA. Plasmodium yoelii: brefeldin A-sensitive processing of proteins targeted to the rhoptries. Exp Parasitol. 1994 Nov; 79(3):270-8. PMID: 7957749.
      View in: PubMed
    197. Chappel JA, Egan AF, Riley EM, Druilhe P, Holder AA. Naturally acquired human antibodies which recognize the first epidermal growth factor-like module in the Plasmodium falciparum merozoite surface protein 1 do not inhibit parasite growth in vitro. Infect Immun. 1994 Oct; 62(10):4488-94. PMID: 7927713; PMCID: PMC303134.
    198. Stafford WH, Blackman MJ, Harris A, Shai S, Grainger M, Holder AA. N-terminal amino acid sequence of the Plasmodium falciparum merozoite surface protein-1 polypeptides. Mol Biochem Parasitol. 1994 Jul; 66(1):157-60. PMID: 7984180.
      View in: PubMed
    199. Blackman MJ, Scott-Finnigan TJ, Shai S, Holder AA. Antibodies inhibit the protease-mediated processing of a malaria merozoite surface protein. J Exp Med. 1994 Jul 01; 180(1):389-93. PMID: 7516416; PMCID: PMC2191569.
    200. Keen JK, Sinha KA, Brown KN, Holder AA. A gene coding for a high-molecular mass rhoptry protein of Plasmodium yoelii. Mol Biochem Parasitol. 1994 May; 65(1):171-7. PMID: 7935623.
      View in: PubMed
    201. Holder AA, Blackman MJ. What is the function of MSP-I on the malaria merozoite? Parasitol Today. 1994 May; 10(5):182-4. PMID: 15275468.
      View in: PubMed
    202. Holder AA, Blackman MJ, Borre M, Burghaus PA, Chappel JA, Keen JK, Ling IT, Ogun SA, Owen CA, Sinha KA. Malaria parasites and erythrocyte invasion. Biochem Soc Trans. 1994 May; 22(2):291-5. PMID: 7958309.
      View in: PubMed
    203. Burghaus PA, Holder AA. Expression of the 19-kilodalton carboxy-terminal fragment of the Plasmodium falciparum merozoite surface protein-1 in Escherichia coli as a correctly folded protein. Mol Biochem Parasitol. 1994 Mar; 64(1):165-9. PMID: 8078519.
      View in: PubMed
    204. Ling IT, Ogun SA, Holder AA. Immunization against malaria with a recombinant protein. Parasite Immunol. 1994 Feb; 16(2):63-7. PMID: 8015856.
      View in: PubMed
    205. Bates S, Bonetta L, MacAllan D, Parry D, Holder A, Dickson C, Peters G. CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1. Oncogene. 1994 Jan; 9(1):71-9. PMID: 8302605.
      View in: PubMed
    206. Holder AA. Proteins on the surface of the malaria parasite and cell invasion. Parasitology. 1994; 108 Suppl:S5-18. PMID: 8084655.
      View in: PubMed
    207. Holder AA. Developments with anti-malarial vaccines. Ann N Y Acad Sci. 1993 Dec 21; 700:7-21. PMID: 8109871.
      View in: PubMed
    208. Strang AM, Allen AK, Holder AA, van Halbeek H. The carbohydrate structures of Trypanosoma brucei brucei MITat 1.6 variant surface glycoprotein. A re-investigation of the C-terminal glycan. Biochem Biophys Res Commun. 1993 Nov 15; 196(3):1430-9. PMID: 8250900.
      View in: PubMed
    209. Blackman MJ, Chappel JA, Shai S, Holder AA. A conserved parasite serine protease processes the Plasmodium falciparum merozoite surface protein-1. Mol Biochem Parasitol. 1993 Nov; 62(1):103-14. PMID: 8114810.
      View in: PubMed
    210. Seesod N, Lunderberg J, Hedrum A, Aslund L, Holder A, Thaithong S, Uhlén M. Immunomagnetic purification to facilitate DNA diagnosis of Plasmodium falciparum. J Clin Microbiol. 1993 Oct; 31(10):2715-9. PMID: 8253971; PMCID: PMC265988.
    211. Haldar K, Holder AA. Export of parasite proteins to the erythrocyte in Plasmodium falciparum-infected cells. Semin Cell Biol. 1993 Oct; 4(5):345-53. PMID: 8257786.
      View in: PubMed
    212. Riley EM, Morris-Jones S, Taylor-Robinson AW, Holder AA. Lymphoproliferative responses to a merozoite surface antigen of Plasmodium falciparum: preliminary evidence for seasonal activation of CD8+/HLA-DQ-restricted suppressor cells. Clin Exp Immunol. 1993 Oct; 94(1):64-7. PMID: 8403519; PMCID: PMC1534374.
    213. Riley EM, Morris-Jones S, Blackman MJ, Greenwood BM, Holder AA. A longitudinal study of naturally acquired cellular and humoral immune responses to a merozoite surface protein (MSP1) of Plasmodium falciparum in an area of seasonal malaria transmission. Parasite Immunol. 1993 Sep; 15(9):513-24. PMID: 7877849.
      View in: PubMed
    214. Chappel JA, Holder AA. Monoclonal antibodies that inhibit Plasmodium falciparum invasion in vitro recognise the first growth factor-like domain of merozoite surface protein-1. Mol Biochem Parasitol. 1993 Aug; 60(2):303-11. PMID: 7694147.
      View in: PubMed
    215. Abath FG, Hagan P, Jeffs SA, Schechter I, Meadows HM, Holder AA, Simpson AJ. Structure of the gene encoding a putative Schistosoma mansoni tegumental antigen precursor. Mol Biochem Parasitol. 1993 Jul; 60(1):81-91. PMID: 8366897.
      View in: PubMed
    216. Dieye A, Heidrich HG, Rogier C, Trape JF, Launois P, Holder AA, Sarthou JL. Lymphocyte response in vitro to Plasmodium falciparum merozoite antigens in donors from a holoendemic area. Parassitologia. 1993 Jul; 35 Suppl:35-8. PMID: 8233608.
      View in: PubMed
    217. Blackman MJ, Holder AA. Use of a recombinant baculovirus product to measure naturally-acquired human antibodies to disulphide-constrained epitopes on the P. falciparum merozoite surface protein-1 (MSP1). FEMS Immunol Med Microbiol. 1993 Apr; 6(4):307-15. PMID: 7684635.
      View in: PubMed
    218. Palmero I, Holder A, Sinclair AJ, Dickson C, Peters G. Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines. Oncogene. 1993 Apr; 8(4):1049-54. PMID: 8455931.
      View in: PubMed
    219. Dieye A, Heidrich HG, Rogier C, Trape JF, Launois P, Holder AA, Sarthou JL. Lymphocyte response in vitro to Plasmodium falciparum merozoite antigens in donors from a holoendemic area. Parasitol Res. 1993; 79(8):629-33. PMID: 8295898.
      View in: PubMed
    220. Riley EM, Olerup O, Bennett S, Rowe P, Allen SJ, Blackman MJ, Troye-Blomberg M, Holder AA, Greenwood BM. MHC and malaria: the relationship between HLA class II alleles and immune responses to Plasmodium falciparum. Int Immunol. 1992 Sep; 4(9):1055-63. PMID: 1390436.
      View in: PubMed
    221. Riley EM, Allen SJ, Wheeler JG, Blackman MJ, Bennett S, Takacs B, Schönfeld HJ, Holder AA, Greenwood BM. Naturally acquired cellular and humoral immune responses to the major merozoite surface antigen (PfMSP1) of Plasmodium falciparum are associated with reduced malaria morbidity. Parasite Immunol. 1992 May; 14(3):321-37. PMID: 1625908.
      View in: PubMed
    222. Blackman MJ, Holder AA. Secondary processing of the Plasmodium falciparum merozoite surface protein-1 (MSP1) by a calcium-dependent membrane-bound serine protease: shedding of MSP133 as a noncovalently associated complex with other fragments of the MSP1. Mol Biochem Parasitol. 1992 Feb; 50(2):307-15. PMID: 1741018.
      View in: PubMed
    223. McCallum-Deighton N, Holder AA. The role of calcium in the invasion of human erythrocytes by Plasmodium falciparum. Mol Biochem Parasitol. 1992 Feb; 50(2):317-23. PMID: 1741019.
      View in: PubMed
    224. Holder AA, Blackman MJ, Burghaus PA, Chappel JA, Ling IT, McCallum-Deighton N, Shai S. A malaria merozoite surface protein (MSP1)-structure, processing and function. Mem Inst Oswaldo Cruz. 1992; 87 Suppl 3:37-42. PMID: 1343716.
      View in: PubMed
    225. Dieckmann-Schuppert A, Bender S, Holder AA, Haldar K, Schwarz RT. Labeling and initial characterization of polar lipids in cultures of Plasmodium falciparum. Parasitol Res. 1992; 78(5):416-22. PMID: 1495920.
      View in: PubMed
    226. Blackman MJ, Ling IT, Nicholls SC, Holder AA. Proteolytic processing of the Plasmodium falciparum merozoite surface protein-1 produces a membrane-bound fragment containing two epidermal growth factor-like domains. Mol Biochem Parasitol. 1991 Nov; 49(1):29-33. PMID: 1775158.
      View in: PubMed
    227. Blackman MJ, Whittle H, Holder AA. Processing of the Plasmodium falciparum major merozoite surface protein-1: identification of a 33-kilodalton secondary processing product which is shed prior to erythrocyte invasion. Mol Biochem Parasitol. 1991 Nov; 49(1):35-44. PMID: 1723148.
      View in: PubMed
    228. Holder AA, Keen JK, Sinha KA, Brown KN. The 235 kD rhoptry protein of Plasmodium yoelii. Acta Leiden. 1991; 60(1):101-6. PMID: 1820696.
      View in: PubMed
    229. Keen J, Holder A, Playfair J, Lockyer M, Lewis A. Identification of the gene for a Plasmodium yoelii rhoptry protein. Multiple copies in the parasite genome. Mol Biochem Parasitol. 1990 Sep-Oct; 42(2):241-6. PMID: 2270106.
      View in: PubMed
    230. Blackman MJ, Heidrich HG, Donachie S, McBride JS, Holder AA. A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies. J Exp Med. 1990 Jul 01; 172(1):379-82. PMID: 1694225; PMCID: PMC2188181.
    231. Murphy VF, Rowan WC, Page MJ, Holder AA. Expression of hybrid malaria antigens in insect cells and their engineering for correct folding and secretion. Parasitology. 1990 Apr; 100 Pt 2:177-83. PMID: 2189112.
      View in: PubMed
    232. Suhrbier A, Holder AA, Wiser MF, Nicholas J, Sinden RE. Expression of the precursor of the major merozoite surface antigens during the hepatic stage of malaria. Am J Trop Med Hyg. 1989 Apr; 40(4):351-5. PMID: 2469336.
      View in: PubMed
    233. Holder AA, Lockyer MJ, Hardy GW. A hybrid gene to express protein epitopes from both sporozoite and merozoite surface antigens of Plasmodium falciparum. Parasitology. 1988 Dec; 97 ( Pt 3):373-82. PMID: 2464153.
      View in: PubMed
    234. Holder AA, Freeman RR, Nicholls SC. Immunization against Plasmodium falciparum with recombinant polypeptides produced in Escherichia coli. Parasite Immunol. 1988 Nov; 10(6):607-17. PMID: 3064031.
      View in: PubMed
    235. Nicholls SC, Hillman Y, Lockyer MJ, Odink KG, Holder AA. An S antigen gene from Plasmodium falciparum contains a novel repetitive sequence. Mol Biochem Parasitol. 1988 Feb; 28(1):11-9. PMID: 2836730.
      View in: PubMed
    236. Holder AA. The precursor to major merozoite surface antigens: structure and role in immunity. Prog Allergy. 1988; 41:72-97. PMID: 3043424.
      View in: PubMed
    237. Holder AA, Sandhu JS, Hillman Y, Davey LS, Nicholls SC, Cooper H, Lockyer MJ. Processing of the precursor to the major merozoite surface antigens of Plasmodium falciparum. Parasitology. 1987 Apr; 94 ( Pt 2):199-208. PMID: 3295686.
      View in: PubMed
    238. Strang AM, Williams JM, Ferguson MA, Holder AA, Allen AK. Trypanosoma brucei brucei variant surface glycoprotein contains non-N-acetylated glucosamine. Biochem J. 1986 Mar 01; 234(2):481-4. PMID: 3718481; PMCID: PMC1146591.
    239. Schwarz RT, Riveros-Moreno V, Lockyer MJ, Nicholls SC, Davey LS, Hillman Y, Sandhu JS, Freeman RR, Holder AA. Structural diversity of the major surface antigen of Plasmodium falciparum merozoites. Mol Cell Biol. 1986 Mar; 6(3):964-8. PMID: 3534552; PMCID: PMC367599.
    240. Playfair JH, De Souza JB, Freeman RR, Holder AA. Vaccination with a purified blood-stage malaria antigen in mice: correlation of protection with T cell mediated immunity. Clin Exp Immunol. 1985 Oct; 62(1):19-23. PMID: 2933196; PMCID: PMC1577400.
    241. Holder AA, Lockyer MJ, Odink KG, Sandhu JS, Riveros-Moreno V, Nicholls SC, Hillman Y, Davey LS, Tizard ML, Schwarz RT, et al. Primary structure of the precursor to the three major surface antigens of Plasmodium falciparum merozoites. Nature. 1985 Sep 19-25; 317(6034):270-3. PMID: 2995820.
      View in: PubMed
    242. Holder AA, Freeman RR, Uni S, Aikawa M. Isolation of a Plasmodium falciparum rhoptry protein. Mol Biochem Parasitol. 1985 Mar; 14(3):293-303. PMID: 3887156.
      View in: PubMed
    243. Aston R, Cooper L, Holder A, Ivanyi J, Preece M. Monoclonal antibodies to human growth hormone can distinguish between pituitary and genetically engineered forms. Mol Immunol. 1985 Mar; 22(3):271-5. PMID: 2582244.
      View in: PubMed
    244. Holder AA, Freeman RR. Protective antigens of rodent and human bloodstage malaria. Philos Trans R Soc Lond B Biol Sci. 1984 Nov 13; 307(1131):171-7. PMID: 6151681.
      View in: PubMed
    245. Holder AA, Freeman RR. The three major antigens on the surface of Plasmodium falciparum merozoites are derived from a single high molecular weight precursor. J Exp Med. 1984 Aug 01; 160(2):624-9. PMID: 6381636; PMCID: PMC2187444.
    246. Odink KG, Lockyer MJ, Nicholls SC, Hillman Y, Freeman RR, Holder AA. Expression of cloned cDNA for a major surface antigen of Plasmodium falciparum merozoites. FEBS Lett. 1984 Jul 23; 173(1):108-12. PMID: 6378659.
      View in: PubMed
    247. Oka M, Aikawa M, Freeman RR, Holder AA, Fine E. Ultrastructural localization of protective antigens of Plasmodium yoelii merozoites by the use of monoclonal antibodies and ultrathin cryomicrotomy. Am J Trop Med Hyg. 1984 May; 33(3):342-6. PMID: 6731669.
      View in: PubMed
    248. Holder AA, Freeman RR. Characterization of a high molecular weight protective antigen of Plasmodium yoelii. Parasitology. 1984 Apr; 88 ( Pt 2):211-9. PMID: 6718053.
      View in: PubMed
    249. Freeman RR, Holder AA. Characteristics of the protective response of BALB/c mice immunized with a purified Plasmodium yoelii schizont antigen. Clin Exp Immunol. 1983 Dec; 54(3):609-16. PMID: 6652973; PMCID: PMC1536166.
    250. Freeman RR, Holder AA. Surface antigens of malaria merozoites. A high molecular weight precursor is processed to an 83,000 mol wt form expressed on the surface of Plasmodium falciparum merozoites. J Exp Med. 1983 Nov 01; 158(5):1647-53. PMID: 6355363; PMCID: PMC2187118.
    251. Holder AA, Freeman RR, Newbold CI. Serological cross-reaction between high molecular weight proteins synthesized in blood schizonts of Plasmodium yoelii, Plasmodium chabaudi and Plasmodium falciparum. Mol Biochem Parasitol. 1983 Nov; 9(3):191-6. PMID: 6201740.
      View in: PubMed
    252. Holder AA. Characterisation of the cross-reacting carbohydrate groups on two variant surface glycoproteins of Trypanosoma brucei. Mol Biochem Parasitol. 1983 Apr; 7(4):331-8. PMID: 6410233.
      View in: PubMed
    253. Freeman RR, Holder AA. Light microscope morphology of Plasmodium falciparum during a synchronized growth cycle in vitro. Ann Trop Med Parasitol. 1983 Feb; 77(1):95-6. PMID: 6349557.
      View in: PubMed
    254. Holder AA. Carbohydrate is linked through ethanolamine to the C-terminal amino acid of Trypanosoma brucei variant surface glycoprotein. Biochem J. 1983 Jan 01; 209(1):261-2. PMID: 6847613; PMCID: PMC1154081.
    255. Holder AA, Freeman RR. Biosynthesis and processing of a Plasmodium falciparum schizont antigen recognized by immune serum and a monoclonal antibody. J Exp Med. 1982 Nov 01; 156(5):1528-38. PMID: 6752328; PMCID: PMC2186849.
    256. Holder AA, Freeman RR. Immunization against blood-stage rodent malaria using purified parasite antigens. Nature. 1981 Nov 26; 294(5839):361-4. PMID: 7312033.
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    257. Shen J, Brackett R, Fischer T, Holder A, Kellogg F, Michael JG. Specific Pseudomonas immunoglobulin E antibodies in sera of patients with cystic fibrosis. Infect Immun. 1981 May; 32(2):967-8. PMID: 6788704; PMCID: PMC351538.
    258. Holder AA, Cross GA. Glycopeptides from variant surface glycoproteins of Trypanosoma Brucei. C-terminal location of antigenically cross-reacting carbohydrate moieties. Mol Biochem Parasitol. 1981 Feb; 2(3-4):135-50. PMID: 6163983.
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    259. von Wettstein D, Poulsen C, Holder AA. Ribulose-1,5-bisphosphate carboxylase as a nuclear and chloroplast marker. Theor Appl Genet. 1978 Sep; 53(5):193-7. PMID: 24309756.
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    260. Brett M, Chambers GK, Holder AA, Fincham JR, Wootton JC. Mutational amino acid replacements in Neurospora crassa NADP-specific glutamate dehydrogenase. J Mol Biol. 1976 Sep 05; 106(1):1-22. PMID: 9517.
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    261. Holder AA, Wootton JC, Baron AJ, Chambers GK, Fincham JR. The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. Peptic and chymotryptic peptides and the complete sequence. Biochem J. 1975 Sep; 149(3):757-73. PMID: 1002; PMCID: PMC1165685.
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