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Professor Cyrus Bacchi

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. O'Sullivan MC, Durham TB, Valdes HE, Dauer KL, Karney NJ, Forrestel AC, Bacchi CJ, Baker JF. Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities. Bioorg Med Chem. 2015 Mar 01; 23(5):996-1010. PMID: 25661449.
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    2. Wring S, Gaukel E, Nare B, Jacobs R, Beaudet B, Bowling T, Mercer L, Bacchi C, Yarlett N, Randolph R, Parham R, Rewerts C, Platner J, Don R. Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis. Parasitology. 2014 Jan; 141(1):104-18. PMID: 24007596; PMCID: PMC3884839.
    3. Jacobs RT, Plattner JJ, Nare B, Wring SA, Chen D, Freund Y, Gaukel EG, Orr MD, Perales JB, Jenks M, Noe RA, Sligar JM, Zhang YK, Bacchi CJ, Yarlett N, Don R. Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis. Future Med Chem. 2011 Aug; 3(10):1259-78. PMID: 21859301.
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    4. Jacobs RT, Nare B, Wring SA, Orr MD, Chen D, Sligar JM, Jenks MX, Noe RA, Bowling TS, Mercer LT, Rewerts C, Gaukel E, Owens J, Parham R, Randolph R, Beaudet B, Bacchi CJ, Yarlett N, Plattner JJ, Freund Y, Ding C, Akama T, Zhang YK, Brun R, Kaiser M, Scandale I, Don R. SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis. PLoS Negl Trop Dis. 2011 Jun; 5(6):e1151. PMID: 21738803; PMCID: PMC3125149.
    5. Perales JB, Freeman J, Bacchi CJ, Bowling T, Don R, Gaukel E, Mercer L, Moore JA, Nare B, Nguyen TM, Noe RA, Randolph R, Rewerts C, Wring SA, Yarlett N, Jacobs RT. SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei. Bioorg Med Chem Lett. 2011 May 15; 21(10):2816-9. PMID: 21507639.
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    6. Mercer L, Bowling T, Perales J, Freeman J, Nguyen T, Bacchi C, Yarlett N, Don R, Jacobs R, Nare B. 2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach. PLoS Negl Trop Dis. 2011 Feb 08; 5(2):e956. PMID: 21347454; PMCID: PMC3035674.
    7. Nare B, Wring S, Bacchi C, Beaudet B, Bowling T, Brun R, Chen D, Ding C, Freund Y, Gaukel E, Hussain A, Jarnagin K, Jenks M, Kaiser M, Mercer L, Mejia E, Noe A, Orr M, Parham R, Plattner J, Randolph R, Rattendi D, Rewerts C, Sligar J, Yarlett N, Don R, Jacobs R. Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis. Antimicrob Agents Chemother. 2010 Oct; 54(10):4379-88. PMID: 20660666; PMCID: PMC2944573.
    8. Ding D, Zhao Y, Meng Q, Xie D, Nare B, Chen D, Bacchi CJ, Yarlett N, Zhang YK, Hernandez V, Xia Y, Freund Y, Abdulla M, Ang KH, Ratnam J, McKerrow JH, Jacobs RT, Zhou H, Plattner JJ. Discovery of novel benzoxaborole-based potent antitrypanosomal agents. ACS Med Chem Lett. 2010 Jul 08; 1(4):165-9. PMID: 24900190; PMCID: PMC4007846.
    9. Huang TL, Vanden Eynde JJ, Mayence A, Collins MS, Cushion MT, Rattendi D, Londono I, Mazumder L, Bacchi CJ, Yarlett N. Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity. Bioorg Med Chem Lett. 2009 Oct 15; 19(20):5884-6. PMID: 19736009; PMCID: PMC2753751.
    10. Bacchi CJ. Chemotherapy of human african trypanosomiasis. Interdiscip Perspect Infect Dis. 2009; 2009:195040. PMID: 19707529; PMCID: PMC2730475.
    11. Bacchi CJ, Barker RH, Rodriguez A, Hirth B, Rattendi D, Yarlett N, Hendrick CL, Sybertz E. Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor. Antimicrob Agents Chemother. 2009 Aug; 53(8):3269-72. PMID: 19451291; PMCID: PMC2715600.
    12. Barker RH, Liu H, Hirth B, Celatka CA, Fitzpatrick R, Xiang Y, Willert EK, Phillips MA, Kaiser M, Bacchi CJ, Rodriguez A, Yarlett N, Klinger JD, Sybertz E. Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. Antimicrob Agents Chemother. 2009 May; 53(5):2052-8. PMID: 19289530; PMCID: PMC2681509.
    13. Bacchi CJ, Yarlett N, Faciane E, Bi X, Rattendi D, Weiss LM, Woster PM. Metabolism of an alkyl polyamine analog by a polyamine oxidase from the microsporidian Encephalitozoon cuniculi. Antimicrob Agents Chemother. 2009 Jun; 53(6):2599-604. PMID: 19223636; PMCID: PMC2687184.
    14. Huang TL, Bacchi CJ, Kode NR, Zhang Q, Wang G, Yartlet N, Rattendi D, Londono I, Mazumder L, Vanden Eynde JJ, Mayence A, Donkor IO. Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug. Int J Antimicrob Agents. 2007 Dec; 30(6):555-61. PMID: 17920820.
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    15. Sufrin JR, Spiess AJ, Marasco CJ, Rattendi D, Bacchi CJ. Novel trypanocidal analogs of 5'-(methylthio)-adenosine. Antimicrob Agents Chemother. 2008 Jan; 52(1):211-9. PMID: 17954686; PMCID: PMC2223900.
    16. Bi X, Lopez C, Bacchi CJ, Rattendi D, Woster PM. Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity. Bioorg Med Chem Lett. 2006 Jun 15; 16(12):3229-32. PMID: 16616495.
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    17. Paul KS, Bacchi CJ, Englund PT. Multiple triclosan targets in Trypanosoma brucei. Eukaryot Cell. 2004 Aug; 3(4):855-61. PMID: 15302818; PMCID: PMC500884.
    18. Bacchi CJ, Rattendi D, Faciane E, Yarlett N, Weiss LM, Frydman B, Woster P, Wei B, Marton LJ, Wittner M. Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues. Microbiology. 2004 May; 150(Pt 5):1215-24. PMID: 15133083; PMCID: PMC3109667.
    19. Werbovetz KA, Sackett DL, Delfín D, Bhattacharya G, Salem M, Obrzut T, Rattendi D, Bacchi C. Selective antimicrotubule activity of N1-phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (GB-II-5) against kinetoplastid parasites. Mol Pharmacol. 2003 Dec; 64(6):1325-33. PMID: 14645662.
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    20. Bacchi CJ, Yarlett N, Weiss LM. Polyamine metabolism in the Microsporidia. Biochem Soc Trans. 2003 Apr; 31(2):420-3. PMID: 12653651.
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    21. Donkor IO, Huang TL, Tao B, Rattendi D, Lane S, Vargas M, Goldberg B, Bacchi C. Trypanocidal activity of conformationally restricted pentamidine congeners. J Med Chem. 2003 Mar 13; 46(6):1041-8. PMID: 12620080.
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    22. Kamnaing P, Tsopmo A, Tanifum EA, Tchuendem MH, Tane P, Ayafor JF, Sterner O, Rattendi D, Iwu MM, Schuster B, Bacchi C. Trypanocidal diarylheptanoids from Aframomum letestuianum. J Nat Prod. 2003 Mar; 66(3):364-7. PMID: 12662093.
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    23. Bacchi CJ, Yarlett N. Polyamine metabolism as chemotherapeutic target in protozoan parasites. Mini Rev Med Chem. 2002 Dec; 2(6):553-63. PMID: 12370040.
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    24. Marasco CJ, Kramer DL, Miller J, Porter CW, Bacchi CJ, Rattendi D, Kucera L, Iyer N, Bernacki R, Pera P, Sufrin JR. Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. J Med Chem. 2002 Nov 07; 45(23):5112-22. PMID: 12408722.
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    25. Vujcic S, Diegelman P, Bacchi CJ, Kramer DL, Porter CW. Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. Biochem J. 2002 Nov 01; 367(Pt 3):665-75. PMID: 12141946; PMCID: PMC1222929.
    26. Bacchi CJ, Weiss LM, Lane S, Frydman B, Valasinas A, Reddy V, Sun JS, Marton LJ, Khan IA, Moretto M, Yarlett N, Wittner M. Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection. Antimicrob Agents Chemother. 2002 Jan; 46(1):55-61. PMID: 11751111; PMCID: PMC127003.
    27. Zou Y, Wu Z, Sirisoma N, Woster PM, Casero RA, Weiss LM, Rattendi D, Lane S, Bacchi CJ. Novel alkylpolyamine analogues that possess both antitrypanosomal and antimicrosporidial activity. Bioorg Med Chem Lett. 2001 Jun 18; 11(12):1613-7. PMID: 11412992; PMCID: PMC3109676.
    28. Donkor IO, Assefa H, Rattendi D, Lane S, Vargas M, Goldberg B, Bacchi C. Trypanocidal activity of dicationic compounds related to pentamidine. Eur J Med Chem. 2001 Jun; 36(6):531-8. PMID: 11525843.
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    29. Bacchi CJ, Lane S, Weiss LM, Yarlett N, Takvorian P, Cali A, Wittner M. Polyamine synthesis and interconversion by the Microsporidian Encephalitozoon cuniculi. J Eukaryot Microbiol. 2001 May-Jun; 48(3):374-81. PMID: 11411847.
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    30. Goldberg B, Rattendi D, Lloyd D, Sufrin JR, Bacchi CJ. In situ kinetic characterization of methylthioadenosine transport by the adenosine transporter (P2) of the African Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. Biochem Pharmacol. 2001 Feb 15; 61(4):449-57. PMID: 11226379.
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    31. Li Z, Fennie MW, Ganem B, Hancock MT, Kobaslija M, Rattendi D, Bacchi CJ, O'Sullivan MC. Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents. Bioorg Med Chem Lett. 2001 Jan 22; 11(2):251-4. PMID: 11206471.
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    32. Bacchi CJ, Orozco D, Weiss LM, Frydman B, Valasinas A, Yarlett N, Marton LJ, Wittner M. SL-11158, a synthetic oligoamine, inhibits polyamine metabolism of Encephalitozoon cuniculi. J Eukaryot Microbiol. 2001; Suppl:92S-94S. PMID: 11906095.
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    33. Bacchi CJ, Braunstein VL, Rattendi D, Yarlett N, Wittner M, Tanowitz HB. Stage-specific polyamine metabolism in Trypanosoma cruzi. J Eukaryot Microbiol. 2001; Suppl:201S-202S. PMID: 11906064.
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    34. Miller MA, McGowan SE, Gantt KR, Champion M, Novick SL, Andersen KA, Bacchi CJ, Yarlett N, Britigan BE, Wilson ME. Inducible resistance to oxidant stress in the protozoan Leishmania chagasi. J Biol Chem. 2000 Oct 27; 275(43):33883-9. PMID: 10931831.
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    35. Goldberg B, Rattendi D, Lloyd D, Yarlett N, Bacchi CJ. Kinetics of methionine transport and metabolism by Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. Arch Biochem Biophys. 2000 May 01; 377(1):49-57. PMID: 10775440.
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    36. Bacchi CJ, Lane S, Rhoden J, Yarlett N, Witner M, Weiss LM. Polyamine synthesis in Encephalitozoon cuniculi. J Eukaryot Microbiol. 1999 Sep-Oct; 46(5):31S. PMID: 10519235.
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    37. Chu PG, Chang KL, Chen WG, Chen YY, Shibata D, Hayashi K, Bacchi C, Bacchi M, Weiss LM. Epstein-Barr virus (EBV) nuclear antigen (EBNA)-4 mutation in EBV-associated malignancies in three different populations. Am J Pathol. 1999 Sep; 155(3):941-7. PMID: 10487851; PMCID: PMC1866909.
    38. Chang KL, Chen YY, Chen WG, Hayashi K, Bacchi C, Bacchi M, Weiss LM. EBNA-1 gene sequences in Brazilian and American patients with Hodgkin's disease. Blood. 1999 Jul 01; 94(1):244-50. PMID: 10381519.
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    39. Goldberg B, Rattendi D, Lloyd D, Yarlett N, Bacchi CJ. Kinetics of S-adenosylmethionine cellular transport and protein methylation in Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. Arch Biochem Biophys. 1999 Apr 01; 364(1):13-8. PMID: 10087160.
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    40. Huang H, Chan J, Wittner M, Jelicks LA, Morris SA, Factor SM, Weiss LM, Braunstein VL, Bacchi CJ, Yarlett N, Chandra M, Shirani J, Tanowitz HB. Expression of cardiac cytokines and inducible form of nitric oxide synthase (NOS2) in Trypanosoma cruzi-infected mice. J Mol Cell Cardiol. 1999 Jan; 31(1):75-88. PMID: 10072717.
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    41. Bacchi CJ, Goldberg B, Rattendi D, Gorrell TE, Spiess AJ, Sufrin JR. Metabolic effects of a methylthioadenosine phosphorylase substrate analog on African trypanosomes. Biochem Pharmacol. 1999 Jan 01; 57(1):89-96. PMID: 9920289.
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    42. Bacchi CJ, Vargas M, Rattendi D, Goldberg B, Zhou W. Antitrypanosomal activity of a new triazine derivative, SIPI 1029, In vitro and in model infections. Antimicrob Agents Chemother. 1998 Oct; 42(10):2718-21. PMID: 9756783; PMCID: PMC105925.
    43. Goldberg B, Rattendi D, Lloyd D, Sufrin JR, Bacchi CJ. Effects of intermediates of methionine metabolism and nucleoside analogs on S-adenosylmethionine transport by Trypanosoma brucei brucei and a drug-resistant Trypanosoma brucei rhodesiense. Biochem Pharmacol. 1998 Jul 01; 56(1):95-103. PMID: 9698093.
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    44. Seley KL, Schneller SW, De Clercq E, Rattendi D, Lane S, Bacchi CJ, Korba B. The importance of the 4'-hydroxyl hydrogen for the anti-trypanosomal and antiviral properties of (+)-5'-noraristeromycin and two 7-deaza analogues. Bioorg Med Chem. 1998 Jun; 6(6):797-801. PMID: 9681145.
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    45. O'Sullivan MC, Zhou Q, Li Z, Durham TB, Rattendi D, Lane S, Bacchi CJ. Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities. Bioorg Med Chem. 1997 Dec; 5(12):2145-55. PMID: 9459012.
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    46. Bacchi CJ, Sanabria K, Spiess AJ, Vargas M, Marasco CJ, Jimenez LM, Goldberg B, Sufrin JR. In vivo efficacies of 5'-methylthioadenosine analogs as trypanocides. Antimicrob Agents Chemother. 1997 Oct; 41(10):2108-12. PMID: 9333033; PMCID: PMC164078.
    47. Seley KL, Schneller SW, Rattendi D, Lane S, Bacchi CJ. Synthesis and antitrypanosomal activities of a series of 7-deaza-5'-noraristeromycin derivatives with variations in the cyclopentyl ring substituents. Antimicrob Agents Chemother. 1997 Aug; 41(8):1658-61. PMID: 9257736; PMCID: PMC163980.
    48. Goldberg B, Rattendi D, Yarlett N, Lloyd D, Bacchi CJ. Effects of carboxylmethylation and polyamine synthesis inhibitors on methylation of Trypanosoma brucei cellular proteins and lipids. J Eukaryot Microbiol. 1997 Jul-Aug; 44(4):352-8. PMID: 9225449.
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    49. Goldberg B, Yarlett N, Rattendi D, Lloyd D, Bacchi CJ. Rapid methylation of cell proteins and lipids in Trypanosoma brucei. J Eukaryot Microbiol. 1997 Jul-Aug; 44(4):345-51. PMID: 9225448.
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    50. Goldberg B, Yarlett N, Sufrin J, Lloyd D, Bacchi CJ. A unique transporter of S-adenosylmethionine in African trypanosomes. FASEB J. 1997 Mar; 11(4):256-60. PMID: 9068614.
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    51. Seley KL, Schneller SW, Rattendi D, Bacchi CJ. (+)-7-Deaza-5'-noraristeromycin as an anti-trypanosomal agent. J Med Chem. 1997 Feb 14; 40(4):622-4. PMID: 9046353.
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    52. Seley KL, Schneller SW, Rattendi D, Lane S, Bacchi CJ. Synthesis and anti-trypanosomal activity of various 8-aza-7-deaza-5'noraristeromycin derivatives. J Med Chem. 1997 Feb 14; 40(4):625-9. PMID: 9046354.
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    53. Sufrin JR, Rattendi D, Spiess AJ, Lane S, Marasco CJ, Bacchi CJ. Antitrypanosomal activity of purine nucleosides can be enhanced by their conversion to O-acetylated derivatives. Antimicrob Agents Chemother. 1996 Nov; 40(11):2567-72. PMID: 8913466; PMCID: PMC163577.
    54. Werbovetz KA, Bacchi CJ, Englund PT. Trypanocidal analogs of myristate and myristoyllysophosphatidylcholine. Mol Biochem Parasitol. 1996 Oct 18; 81(1):115-8. PMID: 8892311.
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    55. Coyle C, Bacchi C, Yarlett N, Tanowitz HB, Wittner M, Weiss LM. Polyamine metabolism as a therapeutic target for Microsporidia. J Eukaryot Microbiol. 1996 Sep-Oct; 43(5):96S. PMID: 8822885.
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    56. Brun R, Bühler Y, Sandmeier U, Kaminsky R, Bacchi CJ, Rattendi D, Lane S, Croft SL, Snowdon D, Yardley V, Caravatti G, Frei J, Stanek J, Mett H. In vitro trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors. Antimicrob Agents Chemother. 1996 Jun; 40(6):1442-7. PMID: 8726017; PMCID: PMC163347.
    57. Bacchi CJ, Brun R, Croft SL, Alicea K, Bühler Y. In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors. Antimicrob Agents Chemother. 1996 Jun; 40(6):1448-53. PMID: 8726018; PMCID: PMC163348.
    58. Alleman MM, Mann VH, Bacchi CJ, Yarlett N, Gottlieb M, Dwyer DM. Crithidia luciliae: effect of purine starvation on S-adenosyl-L-methionine uptake and protein methylation. Exp Parasitol. 1995 Dec; 81(4):519-28. PMID: 8542993.
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    59. Sufrin JR, Meshnick SR, Spiess AJ, Garofalo-Hannan J, Pan XQ, Bacchi CJ. Methionine recycling pathways and antimalarial drug design. Antimicrob Agents Chemother. 1995 Nov; 39(11):2511-5. PMID: 8585735; PMCID: PMC162974.
    60. Bacchi CJ, Goldberg B, Garofalo-Hannan J, Rattendi D, Lyte P, Yarlett N. Fate of soluble methionine in African trypanosomes: effects of metabolic inhibitors. Biochem J. 1995 Aug 01; 309 ( Pt 3):737-43. PMID: 7639687; PMCID: PMC1135694.
    61. Guo J, Wu YQ, Rattendi D, Bacchi CJ, Woster PM. S-(5'-deoxy-5'-adenosyl)-1-aminoxy-4-(methylsulfonio)-2-cyclopentene (AdoMao): an irreversible inhibitor of S-adenosylmethionine decarboxylase with potent in vitro antitrypanosomal activity. J Med Chem. 1995 May 12; 38(10):1770-7. PMID: 7752200.
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    62. Yarlett N, Bacchi CJ. Parasite polyamine metabolism: targets for chemotherapy. Biochem Soc Trans. 1994 Nov; 22(4):875-9. PMID: 7698477.
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    63. Yarlett N, Lindmark DG, Goldberg B, Moharrami MA, Bacchi CJ. Subcellular localization of the enzymes of the arginine dihydrolase pathway in Trichomonas vaginalis and Tritrichomonas foetus. J Eukaryot Microbiol. 1994 Nov-Dec; 41(6):554-9. PMID: 7866382.
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    64. Bacchi CJ, Nathan HC, Yarlett N, Goldberg B, McCann PP, Sjoerdsma A, Saric M, Clarkson AB. Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides. Antimicrob Agents Chemother. 1994 Mar; 38(3):563-9. PMID: 8203855; PMCID: PMC284498.
    65. Bacchi CJ, Yarlett N. Effects of antagonists of polyamine metabolism on African trypanosomes. Acta Trop. 1993 Sep; 54(3-4):225-36. PMID: 7902660.
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    66. Bacchi CJ, Garofalo J, Ciminelli M, Rattendi D, Goldberg B, McCann PP, Yarlett N. Resistance to DL-alpha-difluoromethylornithine by clinical isolates of Trypanosoma brucei rhodesiense. Role of S-adenosylmethionine. Biochem Pharmacol. 1993 Aug 03; 46(3):471-81. PMID: 8347171.
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    67. Yarlett N, Goldberg B, Moharrami MA, Bacchi CJ. Trichomonas vaginalis: characterization of ornithine decarboxylase. Biochem J. 1993 Jul 15; 293 ( Pt 2):487-93. PMID: 8343128; PMCID: PMC1134387.
    68. Bacchi CJ. Resistance to clinical drugs in African trypanosomes. Parasitol Today. 1993 May; 9(5):190-3. PMID: 15463751.
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    69. Yarlett N, Garofalo J, Goldberg B, Ciminelli MA, Ruggiero V, Sufrin JR, Bacchi CJ. S-adenosylmethionine synthetase in bloodstream Trypanosoma brucei. Biochim Biophys Acta. 1993 Mar 24; 1181(1):68-76. PMID: 8457607.
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    70. Bacchi CJ, Nathan HC, Yarlett N, Goldberg B, McCann PP, Bitonti AJ, Sjoerdsma A. Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor. Antimicrob Agents Chemother. 1992 Dec; 36(12):2736-40. PMID: 1482141; PMCID: PMC245537.
    71. Tekwani BL, Bacchi CJ, Pegg AE. Putrescine activated S-adenosylmethionine decarboxylase from Trypanosoma brucei brucei. Mol Cell Biochem. 1992 Nov 04; 117(1):53-61. PMID: 1480164.
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    72. Tekwani BL, Bacchi CJ, Secrist JA, Pegg AE. Irreversible inhibition of S-adenosylmethionine decarboxylase of Trypanosoma brucei brucei by S-adenosylmethionine analogues. Biochem Pharmacol. 1992 Sep 01; 44(5):905-11. PMID: 1530659.
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    73. Yarlett N, Goldberg B, Moharrami MA, Bacchi CJ. Inhibition of Trichomonas vaginalis ornithine decarboxylase by amino acid analogs. Biochem Pharmacol. 1992 Jul 22; 44(2):243-50. PMID: 1642639.
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    74. Bacchi CJ, Sufrin JR, Nathan HC, Spiess AJ, Hannan T, Garofalo J, Alecia K, Katz L, Yarlett N. 5'-Alkyl-substituted analogs of 5'-methylthioadenosine as trypanocides. Antimicrob Agents Chemother. 1991 Jul; 35(7):1315-20. PMID: 1929287; PMCID: PMC245164.
    75. Yarlett N, Quamina A, Bacchi CJ. Protein methylases in Trypanosoma brucei brucei: activities and response to DL-alpha-difluoromethylornithine. J Gen Microbiol. 1991 Mar; 137(3):717-24. PMID: 2033384.
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    76. Yarlett N, Goldberg B, Nathan HC, Garofalo J, Bacchi CJ. Differential sensitivity of Trypanosoma brucei rhodesiense isolates to in vitro lysis by arsenicals. Exp Parasitol. 1991 Feb; 72(2):205-15. PMID: 1849084.
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    77. Bitonti AJ, Byers TL, Bush TL, Casara PJ, Bacchi CJ, Clarkson AB, McCann PP, Sjoerdsma A. Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase. Antimicrob Agents Chemother. 1990 Aug; 34(8):1485-90. PMID: 1977366; PMCID: PMC171857.
    78. Bacchi CJ, Nathan HC, Livingston T, Valladares G, Saric M, Sayer PD, Njogu AR, Clarkson AB. Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense. Antimicrob Agents Chemother. 1990 Jun; 34(6):1183-8. PMID: 2118325; PMCID: PMC171781.
    79. Kini GD, Henry EM, Robins RK, Larson SB, Marr JJ, Berens RL, Bacchi CJ, Nathan HC, Keithly JS. Synthesis, structure, and antiparasitic activity of sulfamoyl derivatives of ribavirin. J Med Chem. 1990 Jan; 33(1):44-8. PMID: 2296034.
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    80. Bacchi CJ, Garofalo J, Santana A, Hannan JC, Bitonti AJ, McCann PP. Trypanosoma brucei brucei: regulation of ornithine decarboxylase in procyclic forms and trypomastigotes. Exp Parasitol. 1989 May; 68(4):392-402. PMID: 2498115.
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    81. Tyms AS, Williamson JD, Bacchi CJ. Polyamine inhibitors in antimicrobial chemotherapy. J Antimicrob Chemother. 1988 Oct; 22(4):403-27. PMID: 3144522.
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    82. Yarlett N, Bacchi CJ. Effect of DL-alpha-difluoromethylornithine on polyamine synthesis and interconversion in Trichomonas vaginalis grown in a semi-defined medium. Mol Biochem Parasitol. 1988 Oct; 31(1):1-9. PMID: 3141809.
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    83. Ghoda LY, Savarese TM, Northup CH, Parks RE, Garofalo J, Katz L, Ellenbogen BB, Bacchi CJ. Substrate specificities of 5'-deoxy-5'-methylthioadenosine phosphorylase from Trypanosoma brucei brucei and mammalian cells. Mol Biochem Parasitol. 1988 Jan 15; 27(2-3):109-18. PMID: 3125430.
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    84. Yarlett N, Bacchi CJ. Effect of DL-alpha-difluoromethylornithine on methionine cycle intermediates in Trypanosoma brucei brucei. Mol Biochem Parasitol. 1988 Jan 01; 27(1):1-10. PMID: 3125429.
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    85. McCann PP, Bacchi CJ, Bitonti AJ, Kierszenbaum F, Sjoerdsma A. Inhibition of ornithine or arginine decarboxylase as an experimental approach to African or American trypanosomiasis. Adv Exp Med Biol. 1988; 250:727-35. PMID: 3151233.
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    86. Bacchi CJ, Berens RL, Nathan HC, Klein RS, Elegbe IA, Rao KV, McCann PP, Marr JJ. Synergism between 9-deazainosine and DL-alpha-difluoromethylornithine in treatment of experimental African trypanosomiasis. Antimicrob Agents Chemother. 1987 Sep; 31(9):1406-13. PMID: 3118799; PMCID: PMC174951.
    87. Fairlamb AH, Henderson GB, Bacchi CJ, Cerami A. In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei. Mol Biochem Parasitol. 1987 Jun; 24(2):185-91. PMID: 3114634.
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    88. Marcus SL, Nathan HC, Hutner SH, Bacchi CJ. Polyamines antagonize both the antileukemic activity and the reverse transcriptase stimulatory activity of 4,4'-diacetyldiphenylurea bis(guanylhydrazone) (DDUG). Biochem Biophys Res Commun. 1987 Jan 30; 142(2):422-7. PMID: 2434093.
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    89. McCann PP, Bitonti AJ, Bacchi CJ, Clarkson AB. Use of difluoromethylornithine (DFMO, eflornithine) for late-stage African trypanosomiasis. Trans R Soc Trop Med Hyg. 1987; 81(4):701-2. PMID: 3127968.
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    90. Bacchi CJ, Nathan HC, Clarkson AB, Bienen EJ, Bitonti AJ, McCann PP, Sjoerdsma A. Effects of the ornithine decarboxylase inhibitors DL-alpha-difluoromethylornithine and alpha-monofluoromethyldehydroornithine methyl ester alone and in combination with suramin against Trypanosoma brucei brucei central nervous system models. Am J Trop Med Hyg. 1987 Jan; 36(1):46-52. PMID: 3101528.
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    91. McCann PP, Bacchi CJ, Clarkson AB, Bey P, Sjoerdsma A, Schecter PJ, Walzer PD, Barlow JL. Inhibition of polyamine biosynthesis by alpha-difluoromethylornithine in African trypanosomes and Pneumocystis carinii as a basis of chemotherapy: biochemical and clinical aspects. Am J Trop Med Hyg. 1986 Nov; 35(6):1153-6. PMID: 3098121.
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    92. Chovan JP, Diccianni MB, Raisfeld-Danse IH, Bacchi CJ, Nathan HC. Bleomycin for the cure of Trypanosoma brucei brucei infections in mice: lack of pulmonary toxicity. Pharmacol Res Commun. 1986 Sep; 18(9):867-73. PMID: 2432623.
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    93. Giffin BF, McCann PP, Bacchi CJ. Effect of putrescine on the respiration of Trypanosoma brucei brucei. Mol Biochem Parasitol. 1986 Aug; 20(2):165-71. PMID: 3092047.
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    94. Giffin BF, McCann PP, Bitonti AJ, Bacchi CJ. Polyamine depletion following exposure to DL-alpha-difluoromethylornithine both in vivo and in vitro initiates morphological alterations and mitochondrial activation in a monomorphic strain of Trypanosoma brucei brucei. J Protozool. 1986 May; 33(2):238-43. PMID: 3090240.
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    95. Bitonti AJ, Bacchi CJ, McCann PP, Sjoerdsma A. Uptake of alpha-difluoromethylornithine by Trypanosoma brucei brucei. Biochem Pharmacol. 1986 Jan 15; 35(2):351-4. PMID: 3080009.
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    96. Bitonti AJ, Bacchi CJ, McCann PP, Sjoerdsma A. Catalytic irreversible inhibition of Trypanosoma brucei brucei ornithine decarboxylase by substrate and product analogs and their effects on murine trypanosomiasis. Biochem Pharmacol. 1985 May 15; 34(10):1773-7. PMID: 3924048.
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    97. Marcus SL, Petrylak DP, Burchenal JJ, Bacchi CJ. Stimulation of Rauscher leukemia virus DNA polymerase DNA-directed DNA synthesis by cationic trypanocides and polyamines. Cancer Res. 1985 Jan; 45(1):112-5. PMID: 3965127.
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    98. Clarkson AB, Bienen EJ, Bacchi CJ, McCann PP, Nathan HC, Hutner SH, Sjoerdsma A. New drug combination for experimental late-stage African trypanosomiasis: DL-alpha-difluoromethylornithine (DFMO) with suramin. Am J Trop Med Hyg. 1984 Nov; 33(6):1073-7. PMID: 6439061.
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    99. Nathan HC, Bacchi CJ, Nichol CA, Duch DS, Mullaney EA, Hutner SH. Antitumor phthalanilides active in acute and chronic Trypanosoma brucei brucei murine infections. Am J Trop Med Hyg. 1984 Sep; 33(5):845-50. PMID: 6548337.
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    100. Duch DS, Bacchi CJ, Edelstein MP, Nichol CA. Inhibitors of histamine metabolism in vitro and in vivo. Correlations with antitrypanosomal activity. Biochem Pharmacol. 1984 May 01; 33(9):1547-53. PMID: 6428421.
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    101. Hannan JC, Bacchi CJ, McCann PP. Induction of ornithine decarboxylase in Leptomonas seymouri. Mol Biochem Parasitol. 1984 May; 12(1):117-24. PMID: 6540367.
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    102. Clarkson AB, Bacchi CJ, Mellow GH, Nathan HC, McCann PP, Sjoerdsma A. Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis. Proc Natl Acad Sci U S A. 1983 Sep; 80(18):5729-33. PMID: 6193522; PMCID: PMC384332.
    103. Bacchi CJ, Garofalo J, Mockenhaupt D, McCann PP, Diekema KA, Pegg AE, Nathan HC, Mullaney EA, Chunosoff L, Sjoerdsma A, Hutner SH. In vivo effects of alpha-DL-difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei. Mol Biochem Parasitol. 1983 Mar; 7(3):209-25. PMID: 6193423.
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    104. McCann PP, Bacchi CJ, Hanson WL, Nathan HC, Hutner SH, Sjoerdsma A. Methods for the study of the treatment of protozoan diseases by inhibitors of ornithine decarboxylase. Methods Enzymol. 1983; 94:209-13. PMID: 6413817.
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    105. Bacchi CJ, Nathan HC, Hutner SH, McCann PP, Sjoerdsma A. Novel combination chemotherapy of experimental trypanosomiasis by using bleomycin and DL-alpha-difluoromethylornithine; reversal by polyamines. Biochem Pharmacol. 1982 Sep 01; 31(17):2833-6. PMID: 6182888.
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    106. Garofalo J, Bacchi CJ, McLaughlin SD, Mockenhaupt D, Trueba G, Hutner SH. Ornithine decarboxylase in Trypanosoma brucei brucei: evidence for selective toxicity of difluoromethylornithine. J Protozool. 1982 Aug; 29(3):389-94. PMID: 6813460.
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    107. Marcus SL, Kopelman R, Koll B, Bacchi CJ. Effects of exogenous polyamine and trypanocides on the DNA polymerase activities from Trypanosoma brucei brucei, mouse thymus and murine leukemia virus. Mol Biochem Parasitol. 1982 Apr; 5(4):231-43. PMID: 6178972.
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    108. Shapiro A, Nathan HC, Hutner SH, Garofalo J, McLaughlin SD, Rescigno D, Bacchi CJ. In vivo and in vitro activity by diverse chelators against Trypanosoma brucei brucei. J Protozool. 1982 Feb; 29(1):85-90. PMID: 6123596.
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    109. McCann PP, Bacchi CJ, Clarkson AB, Seed JR, Nathan HC, Amole BO, Hutner SH, Sjoerdsma A. Further studies on difluoromethylornithine in African trypanosomes. Med Biol. 1981 Dec; 59(5-6):434-40. PMID: 6175860.
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    110. Nathan HC, Bacchi CJ, Hutner SH, Rescigno D, McCann PP, Sjoerdsma A. Antagonism by polyamines of the curative effects of alpha-difluoromethylornithine in Trypanosoma brucei brucei infections. Biochem Pharmacol. 1981 Nov 01; 30(21):3010-3. PMID: 6797437.
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    111. Shapiro A, Hutner SH, Katz L, Bacchi CJ. Rapid in vitro prescreen for chelators as potential trypanocides based on growth of Crithidia fasciculata. J Protozool. 1981 Aug; 28(3):370-7. PMID: 7310745.
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    112. Bacchi CJ, Nathan HC, Hutner SH, Duch DS, Nichol CA. Prevention by polyamines of the curative effect of amicarbalide and imidocarb for Trypanosoma brucei infections in mice. Biochem Pharmacol. 1981 Apr 15; 30(8):883-6. PMID: 7247968.
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    113. Marcus SL, Smith SW, Bacchi CJ. Polyamines stimulate DNA-directed DNA synthesis catalyzed by mammalian type C retroviral DNA polymerases. J Biol Chem. 1981 Apr 10; 256(7):3460-4. PMID: 6259167.
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    114. Bacchi CJ. Content, synthesis, and function of polyamines in trypanosomatids: relationship to chemotherapy. J Protozool. 1981 Feb; 28(1):20-7. PMID: 6788943.
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    115. Nathan HC, Bacchi CJ, Sakai TT, Rescigno D, Stumpf D, Hutner SH. Bleomycin-induced life prolongation of mice infected with Trypanosoma brucei brucei EATRO 110. Trans R Soc Trop Med Hyg. 1981; 75(3):394-8. PMID: 6172890.
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    116. Bacchi CJ, Nathan HC, Hutner SH, McCann PP, Sjoerdsma A. Polyamine metabolism: a potential therapeutic target in trypanosomes. Science. 1980 Oct 17; 210(4467):332-4. PMID: 6775372.
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    117. Marcus SL, Lipschik G, Trueba G, Bacchi CJ. Chromatographic resolution of two DNA polymerase activities from bloodstream forms of Trypanosoma brucei: differential responses to exogenous polyamine addition. Biochem Biophys Res Commun. 1980 Apr 29; 93(4):1027-35. PMID: 7396895.
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    118. Nathan HC, Soto KV, Moreira R, Chunosoff L, Hutner SH, Bacchi CJ. Curative effects of the antipiroplasms amicarbalide and imidocarb on Trypanosoma brucei infection in mice. J Protozool. 1979 Nov; 26(4):657-60. PMID: 544802.
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    119. Bacchi CJ, Vergara C, Garofalo J, Lipschik GY, Hutner SH. Synthesis and content of polyamines in bloodstream Trypanosma brucei. J Protozool. 1979 Aug; 26(3):484-8. PMID: 536937.
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    120. Bacchi CJ, Lipschik GY, Nathan HC. Polyamines in trypanosomatids. J Bacteriol. 1977 Aug; 131(2):657-61. PMID: 885842; PMCID: PMC235476.
    121. Lambros C, Bacchi CJ, Marcus SL, Hutner SH. Paradoxical activation of Leptomonas NAD-linked alpha-glycerophosphate dehydrogenase by ethidium and antrycide. Biochem Biophys Res Commun. 1977 Feb 07; 74(3):1227-34. PMID: 191012.
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    122. Bacchi CJ, Lambros C, Ellenbogen BB, Penkovsky LN, Sullivan W, Eyinna EE, Hutner SH. Drug-resistant Leptomonas: cross-resistance in trypanocide-resistant clones. Antimicrob Agents Chemother. 1975 Dec; 8(6):688-92. PMID: 1211922; PMCID: PMC429449.
    123. Bacchi CJ, Marcus SL, Lambros C, Goldberg B, Messina L, Hutner SH. Unsubstituted agarose as an affinity matrix for isolation of NAD-dependent alpha-glycerophosphate dehydrogenase from the trypanosomatid Crithidia fasciculata. Biochem Biophys Res Commun. 1974 Jun 04; 58(3):778-86. PMID: 4365735.
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    124. Goldberg B, Lambros C, Bacchi CJ, Hutner SH. Inhibition by several standard antiprotozoal drugs of growth and O2 uptake of cells and particulate preparations of a Leptomonas. J Protozool. 1974 May; 21(2):322-6. PMID: 4365631.
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    125. Bacchi CJ, Ciaccio EI, Koren LE. Effects of some antitumor agents on growth and glycolytic enzymes of the flagellate Crithidia. J Bacteriol. 1969 Apr; 98(1):23-8. PMID: 5781578; PMCID: PMC249898.
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