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Dr Louis Miller

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Azasi Y, Lindergard G, Ghumra A, Mu J, Miller LH, Rowe JA. Infected erythrocytes expressing DC13 PfEMP1 differ from recombinant proteins in EPCR-binding function. Proc Natl Acad Sci U S A. 2018 Jan 30; 115(5):1063-1068. PMID: 29339517.
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    2. Bansal A, Molina-Cruz A, Brzostowski J, Liu P, Luo Y, Gunalan K, Li Y, Ribeiro JMC, Miller LH. PfCDPK1 is critical for malaria parasite gametogenesis and mosquito infection. Proc Natl Acad Sci U S A. 2018 Jan 23; 115(4):774-779. PMID: 29311293.
      View in: PubMed
    3. Bansal A, Molina-Cruz A, Brzostowski J, Mu J, Miller LH. Plasmodium falciparum Calcium-Dependent Protein Kinase 2 Is Critical for Male Gametocyte Exflagellation but Not Essential for Asexual Proliferation. MBio. 2017 Oct 17; 8(5). PMID: 29042501.
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    4. Gunalan K, Lo E, Hostetler JB, Yewhalaw D, Mu J, Neafsey DE, Yan G, Miller LH. Role of Plasmodium vivax Duffy-binding protein 1 in invasion of Duffy-null Africans. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6271-6. PMID: 27190089; PMCID: PMC4896682.
    5. Draper SJ, Angov E, Horii T, Miller LH, Srinivasan P, Theisen M, Biswas S. Recent advances in recombinant protein-based malaria vaccines. Vaccine. 2015 Dec 22; 33(52):7433-43. PMID: 26458807; PMCID: PMC4687528.
    6. Gordon EB, Hart GT, Tran TM, Waisberg M, Akkaya M, Kim AS, Hamilton SE, Pena M, Yazew T, Qi CF, Lee CF, Lo YC, Miller LH, Powell JD, Pierce SK. Targeting glutamine metabolism rescues mice from late-stage cerebral malaria. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):13075-80. PMID: 26438846; PMCID: PMC4620853.
    7. Gordon EB, Hart GT, Tran TM, Waisberg M, Akkaya M, Skinner J, Zinöcker S, Pena M, Yazew T, Qi CF, Miller LH, Pierce SK. Inhibiting the Mammalian target of rapamycin blocks the development of experimental cerebral malaria. MBio. 2015 Jun 02; 6(3):e00725. PMID: 26037126; PMCID: PMC4453009.
    8. Arama C, Maiga B, Dolo A, Kouriba B, Traoré B, Crompton PD, Pierce SK, Troye-Blomberg M, Miller LH, Doumbo OK. Ethnic differences in susceptibility to malaria: what have we learned from immuno-epidemiological studies in West Africa? Acta Trop. 2015 Jun; 146:152-6. PMID: 25820030.
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    9. Desai SA, Miller LH. Malaria: Protein-export pathway illuminated. Nature. 2014 Jul 31; 511(7511):541-2. PMID: 25043009; PMCID: PMC4151513.
    10. Srinivasan P, Ekanem E, Diouf A, Tonkin ML, Miura K, Boulanger MJ, Long CA, Narum DL, Miller LH. Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10311-6. PMID: 24958881; PMCID: PMC4104859.
    11. Crompton PD, Moebius J, Portugal S, Waisberg M, Hart G, Garver LS, Miller LH, Barillas-Mury C, Pierce SK. Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease. Annu Rev Immunol. 2014; 32:157-87. PMID: 24655294; PMCID: PMC4075043.
    12. Tran TM, Ongoiba A, Coursen J, Crosnier C, Diouf A, Huang CY, Li S, Doumbo S, Doumtabe D, Kone Y, Bathily A, Dia S, Niangaly M, Dara C, Sangala J, Miller LH, Doumbo OK, Kayentao K, Long CA, Miura K, Wright GJ, Traore B, Crompton PD. Naturally acquired antibodies specific for Plasmodium falciparum reticulocyte-binding protein homologue 5 inhibit parasite growth and predict protection from malaria. J Infect Dis. 2014 Mar 01; 209(5):789-98. PMID: 24133188; PMCID: PMC3923542.
    13. Jiang L, Mu J, Zhang Q, Ni T, Srinivasan P, Rayavara K, Yang W, Turner L, Lavstsen T, Theander TG, Peng W, Wei G, Jing Q, Wakabayashi Y, Bansal A, Luo Y, Ribeiro JM, Scherf A, Aravind L, Zhu J, Zhao K, Miller LH. PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum. Nature. 2013 Jul 11; 499(7457):223-7. PMID: 23823717; PMCID: PMC3770130.
    14. Knöckel J, Molina-Cruz A, Fischer E, Muratova O, Haile A, Barillas-Mury C, Miller LH. An impossible journey? The development of Plasmodium falciparum NF54 in Culex quinquefasciatus. PLoS One. 2013; 8(5):e63387. PMID: 23658824; PMCID: PMC3643899.
    15. Tonkin ML, Arredondo SA, Loveless BC, Serpa JJ, Makepeace KA, Sundar N, Petrotchenko EV, Miller LH, Grigg ME, Boulanger MJ. Structural and biochemical characterization of Plasmodium falciparum 12 (Pf12) reveals a unique interdomain organization and the potential for an antiparallel arrangement with Pf41. J Biol Chem. 2013 May 03; 288(18):12805-17. PMID: 23511632; PMCID: PMC3642325.
    16. Miura K, Herrera R, Diouf A, Zhou H, Mu J, Hu Z, MacDonald NJ, Reiter K, Nguyen V, Shimp RL, Singh K, Narum DL, Long CA, Miller LH. Overcoming allelic specificity by immunization with five allelic forms of Plasmodium falciparum apical membrane antigen 1. Infect Immun. 2013 May; 81(5):1491-501. PMID: 23429537; PMCID: PMC3648006.
    17. Miller LH, Ackerman HC, Su XZ, Wellems TE. Malaria biology and disease pathogenesis: insights for new treatments. Nat Med. 2013 Feb; 19(2):156-67. PMID: 23389616; PMCID: PMC4783790.
    18. Obiakor H, Avril M, Macdonald NJ, Srinivasan P, Reiter K, Anderson C, Holmes KL, Fried M, Duffy PE, Smith JD, Narum DL, Miller LH. Identification of VAR2CSA domain-specific inhibitory antibodies of the Plasmodium falciparum erythrocyte membrane protein 1 using a novel flow cytometry assay. Clin Vaccine Immunol. 2013 Mar; 20(3):433-42. PMID: 23345587; PMCID: PMC3592344.
    19. Srinivasan P, Yasgar A, Luci DK, Beatty WL, Hu X, Andersen J, Narum DL, Moch JK, Sun H, Haynes JD, Maloney DJ, Jadhav A, Simeonov A, Miller LH. Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion. Nat Commun. 2013; 4:2261. PMID: 23907321; PMCID: PMC3755449.
    20. Zhu D, Qian F, Wu Y, Jones DS, Rowe C, Narum DL, Duffy P, Miller LH, Saul A. Determination of protein concentration for protein-protein conjugates using ultraviolet absorption. J Immunol Methods. 2013 Jan 31; 387(1-2):317-21. PMID: 23098838; PMCID: PMC3529773.
    21. Pal-Bhowmick I, Andersen J, Srinivasan P, Narum DL, Bosch J, Miller LH. Binding of aldolase and glyceraldehyde-3-phosphate dehydrogenase to the cytoplasmic tails of Plasmodium falciparum merozoite duffy binding-like and reticulocyte homology ligands. MBio. 2012; 3(5). PMID: 22991428; PMCID: PMC3448169.
    22. Qian F, Reiter K, Zhang Y, Shimp RL, Nguyen V, Aebig JA, Rausch KM, Zhu D, Lambert L, Mullen GE, Martin LB, Long CA, Miller LH, Narum DL. Immunogenicity of self-associated aggregates and chemically cross-linked conjugates of the 42 kDa Plasmodium falciparum merozoite surface protein-1. PLoS One. 2012; 7(6):e36996. PMID: 22675476; PMCID: PMC3366955.
    23. Portugal S, Doumtabe D, Traore B, Miller LH, Troye-Blomberg M, Doumbo OK, Dolo A, Pierce SK, Crompton PD. B cell analysis of ethnic groups in Mali with differential susceptibility to malaria. Malar J. 2012 May 11; 11:162. PMID: 22577737; PMCID: PMC3507766.
    24. Arredondo SA, Cai M, Takayama Y, MacDonald NJ, Anderson DE, Aravind L, Clore GM, Miller LH. Structure of the Plasmodium 6-cysteine s48/45 domain. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6692-7. PMID: 22493233; PMCID: PMC3340019.
    25. Uchime O, Herrera R, Reiter K, Kotova S, Shimp RL, Miura K, Jones D, Lebowitz J, Ambroggio X, Hurt DE, Jin AJ, Long C, Miller LH, Narum DL. Analysis of the conformation and function of the Plasmodium falciparum merozoite proteins MTRAP and PTRAMP. Eukaryot Cell. 2012 May; 11(5):615-25. PMID: 22467743; PMCID: PMC3346429.
    26. Waisberg M, Cerqueira GC, Yager SB, Francischetti IM, Lu J, Gera N, Srinivasan P, Miura K, Rada B, Lukszo J, Barbian KD, Leto TL, Porcella SF, Narum DL, El-Sayed N, Miller LH, Pierce SK. Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P. Proc Natl Acad Sci U S A. 2012 Apr 03; 109(14):5429-34. PMID: 22431641; PMCID: PMC3325673.
    27. Zhu D, Huang S, McClellan H, Dai W, Syed NR, Gebregeorgis E, Rausch KM, Mullen GE, Long C, Martin LB, Narum D, Duffy P, Miller LH, Saul A. Efficient extraction of vaccines formulated in aluminum hydroxide gel by including surfactants in the extraction buffer. Vaccine. 2012 Jan 05; 30(2):189-94. PMID: 22107848; PMCID: PMC3246088.
    28. Miller LH, Su X. Artemisinin: discovery from the Chinese herbal garden. Cell. 2011 Sep 16; 146(6):855-8. PMID: 21907397; PMCID: PMC3414217.
    29. Srinivasan P, Beatty WL, Diouf A, Herrera R, Ambroggio X, Moch JK, Tyler JS, Narum DL, Pierce SK, Boothroyd JC, Haynes JD, Miller LH. Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion. Proc Natl Acad Sci U S A. 2011 Aug 09; 108(32):13275-80. PMID: 21788485; PMCID: PMC3156155.
    30. Wykes MN, Kay JG, Manderson A, Liu XQ, Brown DL, Richard DJ, Wipasa J, Jiang SH, Jones MK, Janse CJ, Waters AP, Pierce SK, Miller LH, Stow JL, Good MF. Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice. Proc Natl Acad Sci U S A. 2011 Jul 05; 108(27):11205-10. PMID: 21690346; PMCID: PMC3131307.
    31. Miura K, Perera S, Brockley S, Zhou H, Aebig JA, Moretz SE, Miller LH, Doumbo OK, Sagara I, Dicko A, Ellis RD, Long CA. Non-apical membrane antigen 1 (AMA1) IgGs from Malian children interfere with functional activity of AMA1 IgGs as judged by growth inhibition assay. PLoS One. 2011; 6(6):e20947. PMID: 21695140; PMCID: PMC3113848.
    32. Jiang L, Gaur D, Mu J, Zhou H, Long CA, Miller LH. Evidence for erythrocyte-binding antigen 175 as a component of a ligand-blocking blood-stage malaria vaccine. Proc Natl Acad Sci U S A. 2011 May 03; 108(18):7553-8. PMID: 21502513; PMCID: PMC3088598.
    33. Miura K, Zhou H, Diouf A, Tullo G, Moretz SE, Aebig JA, Fay MP, Miller LH, Doumbo OK, Sagara I, Dicko A, Long CA, Ellis RD. Immunological responses against Plasmodium falciparum Apical Membrane Antigen 1 vaccines vary depending on the population immunized. Vaccine. 2011 Mar 09; 29(12):2255-61. PMID: 21277408; PMCID: PMC3046304.
    34. Waisberg M, Tarasenko T, Vickers BK, Scott BL, Willcocks LC, Molina-Cruz A, Pierce MA, Huang CY, Torres-Velez FJ, Smith KG, Barillas-Mury C, Miller LH, Pierce SK, Bolland S. Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice. Proc Natl Acad Sci U S A. 2011 Jan 18; 108(3):1122-7. PMID: 21187399; PMCID: PMC3024697.
    35. Crompton PD, Pierce SK, Miller LH. Advances and challenges in malaria vaccine development. J Clin Invest. 2010 Dec; 120(12):4168-78. PMID: 21123952; PMCID: PMC2994342.
    36. Ouattara A, Mu J, Takala-Harrison S, Saye R, Sagara I, Dicko A, Niangaly A, Duan J, Ellis RD, Miller LH, Su XZ, Plowe CV, Doumbo OK. Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine. Malar J. 2010 Jun 21; 9:175. PMID: 20565971; PMCID: PMC2908102.
    37. Weiss GE, Traore B, Kayentao K, Ongoiba A, Doumbo S, Doumtabe D, Kone Y, Dia S, Guindo A, Traore A, Huang CY, Miura K, Mircetic M, Li S, Baughman A, Narum DL, Miller LH, Doumbo OK, Pierce SK, Crompton PD. The Plasmodium falciparum-specific human memory B cell compartment expands gradually with repeated malaria infections. PLoS Pathog. 2010 May 20; 6(5):e1000912. PMID: 20502681; PMCID: PMC2873912.
    38. Cheru L, Wu Y, Diouf A, Moretz SE, Muratova OV, Song G, Fay MP, Miller LH, Long CA, Miura K. The IC(50) of anti-Pfs25 antibody in membrane-feeding assay varies among species. Vaccine. 2010 Jun 17; 28(27):4423-9. PMID: 20434549; PMCID: PMC2880321.
    39. Crompton PD, Kayala MA, Traore B, Kayentao K, Ongoiba A, Weiss GE, Molina DM, Burk CR, Waisberg M, Jasinskas A, Tan X, Doumbo S, Doumtabe D, Kone Y, Narum DL, Liang X, Doumbo OK, Miller LH, Doolan DL, Baldi P, Felgner PL, Pierce SK. A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray. Proc Natl Acad Sci U S A. 2010 Apr 13; 107(15):6958-63. PMID: 20351286; PMCID: PMC2872454.
    40. Ellis RD, Martin LB, Shaffer D, Long CA, Miura K, Fay MP, Narum DL, Zhu D, Mullen GE, Mahanty S, Miller LH, Durbin AP. Phase 1 trial of the Plasmodium falciparum blood stage vaccine MSP1(42)-C1/Alhydrogel with and without CPG 7909 in malaria naïve adults. PLoS One. 2010 Jan 22; 5(1):e8787. PMID: 20107498; PMCID: PMC2809736.
    41. Miller LH. The Multilateral Initiative on Malaria: looking back and looking ahead. Trends Parasitol. 2010 Mar; 26(3):110-3. PMID: 20097134; PMCID: PMC3415704.
    42. Jiang L, López-Barragán MJ, Jiang H, Mu J, Gaur D, Zhao K, Felsenfeld G, Miller LH. Epigenetic control of the variable expression of a Plasmodium falciparum receptor protein for erythrocyte invasion. Proc Natl Acad Sci U S A. 2010 Feb 02; 107(5):2224-9. PMID: 20080673; PMCID: PMC2836689.
    43. Pierce MA, Ellis RD, Martin LB, Malkin E, Tierney E, Miura K, Fay MP, Marjason J, Elliott SL, Mullen GE, Rausch K, Zhu D, Long CA, Miller LH. Phase 1 safety and immunogenicity trial of the Plasmodium falciparum blood-stage malaria vaccine AMA1-C1/ISA 720 in Australian adults. Vaccine. 2010 Mar 02; 28(10):2236-42. PMID: 20051276; PMCID: PMC2847846.
    44. Kubler-Kielb J, Majadly F, Biesova Z, Mocca CP, Guo C, Nussenzweig R, Nussenzweig V, Mishra S, Wu Y, Miller LH, Keith JM, Liu TY, Robbins JB, Schneerson R. A bicomponent Plasmodium falciparum investigational vaccine composed of protein-peptide conjugates. Proc Natl Acad Sci U S A. 2010 Jan 19; 107(3):1172-7. PMID: 20080619; PMCID: PMC2824317.
    45. Miller LH, Pierce SK. Perspective on malaria eradication: is eradication possible without modifying the mosquito? J Infect Dis. 2009 Dec 01; 200(11):1644-5. PMID: 19877845; PMCID: PMC3412997.
    46. Crompton PD, Miura K, Traore B, Kayentao K, Ongoiba A, Weiss G, Doumbo S, Doumtabe D, Kone Y, Huang CY, Doumbo OK, Miller LH, Long CA, Pierce SK. In vitro growth-inhibitory activity and malaria risk in a cohort study in mali. Infect Immun. 2010 Feb; 78(2):737-45. PMID: 19917712; PMCID: PMC2812204.
    47. Sagara I, Ellis RD, Dicko A, Niambele MB, Kamate B, Guindo O, Sissoko MS, Fay MP, Guindo MA, Kante O, Saye R, Miura K, Long C, Mullen GE, Pierce M, Martin LB, Rausch K, Dolo A, Diallo DA, Miller LH, Doumbo OK. A randomized and controlled Phase 1 study of the safety and immunogenicity of the AMA1-C1/Alhydrogel + CPG 7909 vaccine for Plasmodium falciparum malaria in semi-immune Malian adults. Vaccine. 2009 Dec 09; 27(52):7292-8. PMID: 19874925; PMCID: PMC2808270.
    48. Traore B, Koné Y, Doumbo S, Doumtabé D, Traoré A, Crompton PD, Mircetic M, Huang CY, Kayentao K, Dicko A, Sagara I, Ellis RD, Miura K, Guindo A, Miller LH, Doumbo OK, Pierce SK. The TLR9 agonist CpG fails to enhance the acquisition of Plasmodium falciparum-specific memory B cells in semi-immune adults in Mali. Vaccine. 2009 Dec 09; 27(52):7299-303. PMID: 19712767; PMCID: PMC2788035.
    49. Zhu D, Saul A, Huang S, Martin LB, Miller LH, Rausch KM. Use of o-phthalaldehyde assay to determine protein contents of Alhydrogel-based vaccines. Vaccine. 2009 Oct 09; 27(43):6054-9. PMID: 19660590; PMCID: PMC2753737.
    50. Plassmeyer ML, Reiter K, Shimp RL, Kotova S, Smith PD, Hurt DE, House B, Zou X, Zhang Y, Hickman M, Uchime O, Herrera R, Nguyen V, Glen J, Lebowitz J, Jin AJ, Miller LH, MacDonald NJ, Wu Y, Narum DL. Structure of the Plasmodium falciparum circumsporozoite protein, a leading malaria vaccine candidate. J Biol Chem. 2009 Sep 25; 284(39):26951-63. PMID: 19633296; PMCID: PMC2785382.
    51. Jiang L, Duriseti S, Sun P, Miller LH. Molecular basis of binding of the Plasmodium falciparum receptor BAEBL to erythrocyte receptor glycophorin C. Mol Biochem Parasitol. 2009 Nov; 168(1):49-54. PMID: 19563830; PMCID: PMC2744354.
    52. Ellis RD, Mullen GE, Pierce M, Martin LB, Miura K, Fay MP, Long CA, Shaffer D, Saul A, Miller LH, Durbin AP. A Phase 1 study of the blood-stage malaria vaccine candidate AMA1-C1/Alhydrogel with CPG 7909, using two different formulations and dosing intervals. Vaccine. 2009 Jun 24; 27(31):4104-9. PMID: 19410624; PMCID: PMC2722923.
    53. Miura K, Zhou H, Diouf A, Moretz SE, Fay MP, Miller LH, Martin LB, Pierce MA, Ellis RD, Mullen GE, Long CA. Anti-apical-membrane-antigen-1 antibody is more effective than anti-42-kilodalton-merozoite-surface-protein-1 antibody in inhibiting plasmodium falciparum growth, as determined by the in vitro growth inhibition assay. Clin Vaccine Immunol. 2009 Jul; 16(7):963-8. PMID: 19439523; PMCID: PMC2708396.
    54. Pierce SK, Miller LH. World Malaria Day 2009: what malaria knows about the immune system that immunologists still do not. J Immunol. 2009 May 01; 182(9):5171-7. PMID: 19380759; PMCID: PMC2779769.
    55. Sagara I, Dicko A, Ellis RD, Fay MP, Diawara SI, Assadou MH, Sissoko MS, Kone M, Diallo AI, Saye R, Guindo MA, Kante O, Niambele MB, Miura K, Mullen GE, Pierce M, Martin LB, Dolo A, Diallo DA, Doumbo OK, Miller LH, Saul A. A randomized controlled phase 2 trial of the blood stage AMA1-C1/Alhydrogel malaria vaccine in children in Mali. Vaccine. 2009 May 18; 27(23):3090-8. PMID: 19428923; PMCID: PMC2713037.
    56. Mayer DC, Cofie J, Jiang L, Hartl DL, Tracy E, Kabat J, Mendoza LH, Miller LH. Glycophorin B is the erythrocyte receptor of Plasmodium falciparum erythrocyte-binding ligand, EBL-1. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5348-52. PMID: 19279206; PMCID: PMC2664016.
    57. Crompton PD, Mircetic M, Weiss G, Baughman A, Huang CY, Topham DJ, Treanor JJ, Sanz I, Lee FE, Durbin AP, Miura K, Narum DL, Ellis RD, Malkin E, Mullen GE, Miller LH, Martin LB, Pierce SK. The TLR9 ligand CpG promotes the acquisition of Plasmodium falciparum-specific memory B cells in malaria-naive individuals. J Immunol. 2009 Mar 01; 182(5):3318-26. PMID: 19234231; PMCID: PMC2910392.
    58. Qian F, Aebig JA, Reiter K, Barnafo E, Zhang Y, Shimp RL, Rausch KM, Jones DS, Zhu D, Lambert L, Mullen GE, Narum DL, Miller LH, Wu Y. Enhanced antibody responses to Plasmodium falciparum Pfs28 induced in mice by conjugation to ExoProtein A of Pseudomonas aeruginosa with an improved procedure. Microbes Infect. 2009 Mar; 11(3):408-12. PMID: 19146977; PMCID: PMC2761608.
    59. Miura K, Zhou H, Moretz SE, Diouf A, Thera MA, Dolo A, Doumbo O, Malkin E, Diemert D, Miller LH, Mullen GE, Long CA. Comparison of biological activity of human anti-apical membrane antigen-1 antibodies induced by natural infection and vaccination. J Immunol. 2008 Dec 15; 181(12):8776-83. PMID: 19050299; PMCID: PMC2788747.
    60. Tsai CW, Duggan PF, Jin AJ, Macdonald NJ, Kotova S, Lebowitz J, Hurt DE, Shimp RL, Lambert L, Miller LH, Long CA, Saul A, Narum DL. Characterization of a protective Escherichia coli-expressed Plasmodium falciparum merozoite surface protein 3 indicates a non-linear, multi-domain structure. Mol Biochem Parasitol. 2009 Mar; 164(1):45-56. PMID: 19073223; PMCID: PMC3633458.
    61. Crompton PD, Traore B, Kayentao K, Doumbo S, Ongoiba A, Diakite SA, Krause MA, Doumtabe D, Kone Y, Weiss G, Huang CY, Doumbia S, Guindo A, Fairhurst RM, Miller LH, Pierce SK, Doumbo OK. Sickle cell trait is associated with a delayed onset of malaria: implications for time-to-event analysis in clinical studies of malaria. J Infect Dis. 2008 Nov 01; 198(9):1265-75. PMID: 18752444; PMCID: PMC2574881.
    62. Klein MM, Gittis AG, Su HP, Makobongo MO, Moore JM, Singh S, Miller LH, Garboczi DN. The cysteine-rich interdomain region from the highly variable plasmodium falciparum erythrocyte membrane protein-1 exhibits a conserved structure. PLoS Pathog. 2008 Sep 05; 4(9):e1000147. PMID: 18773118; PMCID: PMC2518858.
    63. Singh K, Gittis AG, Nguyen P, Gowda DC, Miller LH, Garboczi DN. Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A. Nat Struct Mol Biol. 2008 Sep; 15(9):932-8. PMID: 19172746; PMCID: PMC2658892.
    64. Mullen GE, Ellis RD, Miura K, Malkin E, Nolan C, Hay M, Fay MP, Saul A, Zhu D, Rausch K, Moretz S, Zhou H, Long CA, Miller LH, Treanor J. Phase 1 trial of AMA1-C1/Alhydrogel plus CPG 7909: an asexual blood-stage vaccine for Plasmodium falciparum malaria. PLoS One. 2008 Aug 13; 3(8):e2940. PMID: 18698359; PMCID: PMC2491586.
    65. Hayton K, Gaur D, Liu A, Takahashi J, Henschen B, Singh S, Lambert L, Furuya T, Bouttenot R, Doll M, Nawaz F, Mu J, Jiang L, Miller LH, Wellems TE. Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion. Cell Host Microbe. 2008 Jul 17; 4(1):40-51. PMID: 18621009; PMCID: PMC2677973.
    66. Wu Y, Ellis RD, Shaffer D, Fontes E, Malkin EM, Mahanty S, Fay MP, Narum D, Rausch K, Miles AP, Aebig J, Orcutt A, Muratova O, Song G, Lambert L, Zhu D, Miura K, Long C, Saul A, Miller LH, Durbin AP. Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51. PLoS One. 2008 Jul 09; 3(7):e2636. PMID: 18612426; PMCID: PMC2440546.
    67. Qian F, Rausch KM, Muratova O, Zhou H, Song G, Diouf A, Lambert L, Narum DL, Wu Y, Saul A, Miller LH, Long CA, Mullen GE. Addition of CpG ODN to recombinant Pseudomonas aeruginosa ExoProtein A conjugates of AMA1 and Pfs25 greatly increases the number of responders. Vaccine. 2008 May 12; 26(20):2521-7. PMID: 18423804; PMCID: PMC2426823.
    68. Dicko A, Sagara I, Ellis RD, Miura K, Guindo O, Kamate B, Sogoba M, Niambelé MB, Sissoko M, Baby M, Dolo A, Mullen GE, Fay MP, Pierce M, Diallo DA, Saul A, Miller LH, Doumbo OK. Phase 1 study of a combination AMA1 blood stage malaria vaccine in Malian children. PLoS One. 2008 Feb 13; 3(2):e1563. PMID: 18270560; PMCID: PMC2216433.
    69. Huaman MC, Martin LB, Malkin E, Narum DL, Miller LH, Mahanty S, Long CA. Ex vivo cytokine and memory T cell responses to the 42-kDa fragment of Plasmodium falciparum merozoite surface protein-1 in vaccinated volunteers. J Immunol. 2008 Feb 01; 180(3):1451-61. PMID: 18209040.
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    70. Dicko A, Sagara I, Diemert D, Sogoba M, Niambele MB, Dao A, Dolo G, Yalcouye D, Diallo DA, Saul A, Miller LH, Toure YT, Klion AD, Doumbo OK. Year-to-year variation in the age-specific incidence of clinical malaria in two potential vaccine testing sites in Mali with different levels of malaria transmission intensity. Am J Trop Med Hyg. 2007 Dec; 77(6):1028-33. PMID: 18165516.
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    71. Singh S, Plassmeyer M, Gaur D, Miller LH. Mononeme: a new secretory organelle in Plasmodium falciparum merozoites identified by localization of rhomboid-1 protease. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):20043-8. PMID: 18048320; PMCID: PMC2148419.
    72. Miura K, Orcutt AC, Muratova OV, Miller LH, Saul A, Long CA. Development and characterization of a standardized ELISA including a reference serum on each plate to detect antibodies induced by experimental malaria vaccines. Vaccine. 2008 Jan 10; 26(2):193-200. PMID: 18054414; PMCID: PMC2253722.
    73. Gaur D, Singh S, Singh S, Jiang L, Diouf A, Miller LH. Recombinant Plasmodium falciparum reticulocyte homology protein 4 binds to erythrocytes and blocks invasion. Proc Natl Acad Sci U S A. 2007 Nov 06; 104(45):17789-94. PMID: 17971435; PMCID: PMC2077073.
    74. Dicko A, Diemert DJ, Sagara I, Sogoba M, Niambele MB, Assadou MH, Guindo O, Kamate B, Baby M, Sissoko M, Malkin EM, Fay MP, Thera MA, Miura K, Dolo A, Diallo DA, Mullen GE, Long CA, Saul A, Doumbo O, Miller LH. Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians. PLoS One. 2007 Oct 17; 2(10):e1045. PMID: 17940609; PMCID: PMC2013939.
    75. Miura K, Zhou H, Muratova OV, Orcutt AC, Giersing B, Miller LH, Long CA. In immunization with Plasmodium falciparum apical membrane antigen 1, the specificity of antibodies depends on the species immunized. Infect Immun. 2007 Dec; 75(12):5827-36. PMID: 17923516; PMCID: PMC2168362.
    76. Malkin E, Long CA, Stowers AW, Zou L, Singh S, MacDonald NJ, Narum DL, Miles AP, Orcutt AC, Muratova O, Moretz SE, Zhou H, Diouf A, Fay M, Tierney E, Leese P, Mahanty S, Miller LH, Saul A, Martin LB. Phase 1 study of two merozoite surface protein 1 (MSP1(42)) vaccines for Plasmodium falciparum malaria. PLoS Clin Trials. 2007; 2(4):e12. PMID: 17415408; PMCID: PMC1847697.
    77. Qian F, Wu Y, Muratova O, Zhou H, Dobrescu G, Duggan P, Lynn L, Song G, Zhang Y, Reiter K, MacDonald N, Narum DL, Long CA, Miller LH, Saul A, Mullen GE. Conjugating recombinant proteins to Pseudomonas aeruginosa ExoProtein A: a strategy for enhancing immunogenicity of malaria vaccine candidates. Vaccine. 2007 May 16; 25(20):3923-33. PMID: 17428587; PMCID: PMC1940062.
    78. Kubler-Kielb J, Majadly F, Wu Y, Narum DL, Guo C, Miller LH, Shiloach J, Robbins JB, Schneerson R. Long-lasting and transmission-blocking activity of antibodies to Plasmodium falciparum elicited in mice by protein conjugates of Pfs25. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):293-8. PMID: 17190797; PMCID: PMC1765452.
    79. Wu Y, Przysiecki C, Flanagan E, Bello-Irizarry SN, Ionescu R, Muratova O, Dobrescu G, Lambert L, Keister D, Rippeon Y, Long CA, Shi L, Caulfield M, Shaw A, Saul A, Shiver J, Miller LH. Sustained high-titer antibody responses induced by conjugating a malarial vaccine candidate to outer-membrane protein complex. Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48):18243-8. PMID: 17110440; PMCID: PMC1636993.
    80. Singh S, Miura K, Zhou H, Muratova O, Keegan B, Miles A, Martin LB, Saul AJ, Miller LH, Long CA. Immunity to recombinant plasmodium falciparum merozoite surface protein 1 (MSP1): protection in Aotus nancymai monkeys strongly correlates with anti-MSP1 antibody titer and in vitro parasite-inhibitory activity. Infect Immun. 2006 Aug; 74(8):4573-80. PMID: 16861644; PMCID: PMC1539572.
    81. Mayer DC, Jiang L, Achur RN, Kakizaki I, Gowda DC, Miller LH. The glycophorin C N-linked glycan is a critical component of the ligand for the Plasmodium falciparum erythrocyte receptor BAEBL. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2358-62. PMID: 16461900; PMCID: PMC1413722.
    82. Makobongo MO, Keegan B, Long CA, Miller LH. Immunization of Aotus monkeys with recombinant cysteine-rich interdomain region 1 alpha protects against severe disease during Plasmodium falciparum reinfection. J Infect Dis. 2006 Mar 01; 193(5):731-40. PMID: 16453270.
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    83. Tsai CW, Duggan PF, Shimp RL, Miller LH, Narum DL. Overproduction of Pichia pastoris or Plasmodium falciparum protein disulfide isomerase affects expression, folding and O-linked glycosylation of a malaria vaccine candidate expressed in P. pastoris. J Biotechnol. 2006 Feb 24; 121(4):458-70. PMID: 16274825.
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    84. Arévalo-Herrera M, Solarte Y, Zamora F, Mendez F, Yasnot MF, Rocha L, Long C, Miller LH, Herrera S. Plasmodium vivax: transmission-blocking immunity in a malaria-endemic area of Colombia. Am J Trop Med Hyg. 2005 Nov; 73(5 Suppl):38-43. PMID: 16291765.
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    85. Arévalo-Herrera M, Solarte Y, Yasnot MF, Castellanos A, Rincón A, Saul A, Mu J, Long C, Miller L, Herrera S. Induction of transmission-blocking immunity in Aotus monkeys by vaccination with a Plasmodium vivax clinical grade PVS25 recombinant protein. Am J Trop Med Hyg. 2005 Nov; 73(5 Suppl):32-7. PMID: 16291764.
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    86. Gaur D, Furuya T, Mu J, Jiang LB, Su XZ, Miller LH. Upregulation of expression of the reticulocyte homology gene 4 in the Plasmodium falciparum clone Dd2 is associated with a switch in the erythrocyte invasion pathway. Mol Biochem Parasitol. 2006 Feb; 145(2):205-15. PMID: 16289357.
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    87. Miller LH, Saul A, Mahanty S. Revisiting Freund's incomplete adjuvant for vaccines in the developing world. Trends Parasitol. 2005 Sep; 21(9):412-4. PMID: 16043410.
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    88. Seydel KB, Gaur D, Aravind L, Subramanian G, Miller LH. Plasmodium falciparum: characterization of a late asexual stage golgi protein containing both ankyrin and DHHC domains. Exp Parasitol. 2005 Aug; 110(4):389-93. PMID: 15882865.
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    89. Giersing B, Miura K, Shimp R, Wang J, Zhou H, Orcutt A, Stowers A, Saul A, Miller LH, Long C, Singh S. posttranslational modification of recombinant Plasmodium falciparum apical membrane antigen 1: impact on functional immune responses to a malaria vaccine candidate. Infect Immun. 2005 Jul; 73(7):3963-70. PMID: 15972483; PMCID: PMC1168543.
    90. Wang J, Nguyen V, Glen J, Henderson B, Saul A, Miller LH. Improved yield of recombinant merozoite Surface protein 3 (MSP3) from Pichia pastoris using chemically defined media. Biotechnol Bioeng. 2005 Jun 30; 90(7):838-47. PMID: 15849695.
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    91. Malkin EM, Diemert DJ, McArthur JH, Perreault JR, Miles AP, Giersing BK, Mullen GE, Orcutt A, Muratova O, Awkal M, Zhou H, Wang J, Stowers A, Long CA, Mahanty S, Miller LH, Saul A, Durbin AP. Phase 1 clinical trial of apical membrane antigen 1: an asexual blood-stage vaccine for Plasmodium falciparum malaria. Infect Immun. 2005 Jun; 73(6):3677-85. PMID: 15908397; PMCID: PMC1111886.
    92. Malkin EM, Durbin AP, Diemert DJ, Sattabongkot J, Wu Y, Miura K, Long CA, Lambert L, Miles AP, Wang J, Stowers A, Miller LH, Saul A. Phase 1 vaccine trial of Pvs25H: a transmission blocking vaccine for Plasmodium vivax malaria. Vaccine. 2005 May 02; 23(24):3131-8. PMID: 15837212.
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    93. Kato K, Mayer DC, Singh S, Reid M, Miller LH. Domain III of Plasmodium falciparum apical membrane antigen 1 binds to the erythrocyte membrane protein Kx. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5552-7. PMID: 15805191; PMCID: PMC556269.
    94. Gamain B, Trimnell AR, Scheidig C, Scherf A, Miller LH, Smith JD. Identification of multiple chondroitin sulfate A (CSA)-binding domains in the var2CSA gene transcribed in CSA-binding parasites. J Infect Dis. 2005 Mar 15; 191(6):1010-3. PMID: 15717280.
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    95. Gaur D, Mayer DC, Miller LH. Parasite ligand-host receptor interactions during invasion of erythrocytes by Plasmodium merozoites. Int J Parasitol. 2004 Dec; 34(13-14):1413-29. PMID: 15582519.
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    96. Gamain B, Smith JD, Avril M, Baruch DI, Scherf A, Gysin J, Miller LH. Identification of a 67-amino-acid region of the Plasmodium falciparum variant surface antigen that binds chondroitin sulphate A and elicits antibodies reactive with the surface of placental isolates. Mol Microbiol. 2004 Jul; 53(2):445-55. PMID: 15228526.
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    97. Sijwali PS, Kato K, Seydel KB, Gut J, Lehman J, Klemba M, Goldberg DE, Miller LH, Rosenthal PJ. Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8721-6. PMID: 15166288; PMCID: PMC423262.
    98. Dicko A, Klion AD, Théra MA, Sagara I, Yalcouyé D, Niambele MB, Sogoba M, Dolo G, Dao A, Diallo DA, Doumbo OK, Miller LH. The etiology of severe anemia in a village and a periurban area in Mali. Blood. 2004 Aug 15; 104(4):1198-200. PMID: 15113756.
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    99. Mayer DC, Mu JB, Kaneko O, Duan J, Su XZ, Miller LH. Polymorphism in the Plasmodium falciparum erythrocyte-binding ligand JESEBL/EBA-181 alters its receptor specificity. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2518-23. PMID: 14983041; PMCID: PMC356982.
    100. Smith JD, Miller LH. Infected erythrocyte binding to hyaluronic acid and malaria in pregnant women. J Infect Dis. 2004 Jan 15; 189(2):165-8. PMID: 14722879.
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    101. Aravind L, Iyer LM, Wellems TE, Miller LH. Plasmodium biology: genomic gleanings. Cell. 2003 Dec 26; 115(7):771-85. PMID: 14697197.
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    102. Singh S, Kennedy MC, Long CA, Saul AJ, Miller LH, Stowers AW. Biochemical and immunological characterization of bacterially expressed and refolded Plasmodium falciparum 42-kilodalton C-terminal merozoite surface protein 1. Infect Immun. 2003 Dec; 71(12):6766-74. PMID: 14638762; PMCID: PMC308882.
    103. Gaur D, Storry JR, Reid ME, Barnwell JW, Miller LH. Plasmodium falciparum is able to invade erythrocytes through a trypsin-resistant pathway independent of glycophorin B. Infect Immun. 2003 Dec; 71(12):6742-6. PMID: 14638759; PMCID: PMC308933.
    104. Mahanty S, Saul A, Miller LH. Progress in the development of recombinant and synthetic blood-stage malaria vaccines. J Exp Biol. 2003 Nov; 206(Pt 21):3781-8. PMID: 14506213.
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    105. Gratepanche S, Gamain B, Smith JD, Robinson BA, Saul A, Miller LH. Induction of crossreactive antibodies against the Plasmodium falciparum variant protein. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):13007-12. PMID: 14569009; PMCID: PMC240735.
    106. Wellems TE, Miller LH. Two worlds of malaria. N Engl J Med. 2003 Oct 16; 349(16):1496-8. PMID: 14561790.
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    107. Baruch DI, Gamain B, Miller LH. DNA immunization with the cysteine-rich interdomain region 1 of the Plasmodium falciparum variant antigen elicits limited cross-reactive antibody responses. Infect Immun. 2003 Aug; 71(8):4536-43. PMID: 12874333; PMCID: PMC166004.
    108. Mayer DC, Mu JB, Feng X, Su XZ, Miller LH. Polymorphism in a Plasmodium falciparum erythrocyte-binding ligand changes its receptor specificity. J Exp Med. 2002 Dec 02; 196(11):1523-8. PMID: 12461087; PMCID: PMC2194259.
    109. Stowers AW, Kennedy MC, Keegan BP, Saul A, Long CA, Miller LH. Vaccination of monkeys with recombinant Plasmodium falciparum apical membrane antigen 1 confers protection against blood-stage malaria. Infect Immun. 2002 Dec; 70(12):6961-7. PMID: 12438375; PMCID: PMC133036.
    110. Kennedy MC, Wang J, Zhang Y, Miles AP, Chitsaz F, Saul A, Long CA, Miller LH, Stowers AW. In vitro studies with recombinant Plasmodium falciparum apical membrane antigen 1 (AMA1): production and activity of an AMA1 vaccine and generation of a multiallelic response. Infect Immun. 2002 Dec; 70(12):6948-60. PMID: 12438374; PMCID: PMC133034.
    111. Miller LH, Greenwood B. Malaria--a shadow over Africa. Science. 2002 Oct 04; 298(5591):121-2. PMID: 12364787.
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    112. Gamain B, Gratepanche S, Miller LH, Baruch DI. Molecular basis for the dichotomy in Plasmodium falciparum adhesion to CD36 and chondroitin sulfate A. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):10020-4. PMID: 12096191; PMCID: PMC126617.
    113. Egan AF, Fabucci ME, Saul A, Kaslow DC, Miller LH. Aotus New World monkeys: model for studying malaria-induced anemia. Blood. 2002 May 15; 99(10):3863-6. PMID: 11986251.
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    114. Miller LH, Hudson-Taylor D, Gamain B, Saul AJ. Definition of the minimal domain of CIDR1alpha of Plasmodium falciparum PfEMP1 for binding CD36. Mol Biochem Parasitol. 2002 Apr 09; 120(2):321-3. PMID: 11897140.
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    115. Baruch DI, Gamain B, Barnwell JW, Sullivan JS, Stowers A, Galland GG, Miller LH, Collins WE. Immunization of Aotus monkeys with a functional domain of the Plasmodium falciparum variant antigen induces protection against a lethal parasite line. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3860-5. PMID: 11904437; PMCID: PMC122614.
    116. Sagara I, Sangaré D, Dolo G, Guindo A, Sissoko M, Sogoba M, Niambélé MB, Yalcoué D, Kaslow DC, Dicko A, Klion AD, Diallo D, Miller LH, Touré Y, Doumbo O. A high malaria reinfection rate in children and young adults living under a low entomological inoculation rate in a periurban area of Bamako, Mali. Am J Trop Med Hyg. 2002 Mar; 66(3):310-3. PMID: 12139226.
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    117. Hisaeda H, Saul A, Reece JJ, Kennedy MC, Long CA, Miller LH, Stowers AW. Merozoite surface protein 3 and protection against malaria in Aotus nancymai monkeys. J Infect Dis. 2002 Mar 01; 185(5):657-64. PMID: 11865423.
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    118. Miller LH, Baruch DI, Marsh K, Doumbo OK. The pathogenic basis of malaria. Nature. 2002 Feb 07; 415(6872):673-9. PMID: 11832955.
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    119. Weatherall DJ, Miller LH, Baruch DI, Marsh K, Doumbo OK, Casals-Pascual C, Roberts DJ. Malaria and the red cell. Hematology Am Soc Hematol Educ Program. 2002; 35-57. PMID: 12446418.
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    120. Stowers AW, Chen Lh LH, Zhang Y, Kennedy MC, Zou L, Lambert L, Rice TJ, Kaslow DC, Saul A, Long CA, Meade H, Miller LH. A recombinant vaccine expressed in the milk of transgenic mice protects Aotus monkeys from a lethal challenge with Plasmodium falciparum. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):339-44. PMID: 11752405; PMCID: PMC117562.
    121. Moulds JM, Zimmerman PA, Doumbo OK, Kassambara L, Sagara I, Diallo DA, Atkinson JP, Krych-Goldberg M, Hauhart RE, Hourcade DE, McNamara DT, Birmingham DJ, Rowe JA, Moulds JJ, Miller LH. Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1. Blood. 2001 May 01; 97(9):2879-85. PMID: 11313284.
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    122. Miller LH. Evolution of the human genome under selective pressure from malaria: applications for control. Parassitologia. 1999 Sep; 41(1-3):77-82. PMID: 10697836.
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    123. Hirunpetcharat C, Stanisic D, Liu XQ, Vadolas J, Strugnell RA, Lee R, Miller LH, Kaslow DC, Good MF. Intranasal immunization with yeast-expressed 19 kD carboxyl-terminal fragment of Plasmodium yoelii merozoite surface protein-1 (yMSP119) induces protective immunity to blood stage malaria infection in mice. Parasite Immunol. 1998 Sep; 20(9):413-20. PMID: 9767608.
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    124. Tian JH, Good MF, Hirunpetcharat C, Kumar S, Ling IT, Jackson D, Cooper J, Lukszo J, Coligan J, Ahlers J, Saul A, Berzofsky JA, Holder AA, Miller LH, Kaslow DC. Definition of T cell epitopes within the 19 kDa carboxylterminal fragment of Plasmodium yoelii merozoite surface protein 1 (MSP1(19)) and their role in immunity to malaria. Parasite Immunol. 1998 Jun; 20(6):263-78. PMID: 9651928.
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    125. Good MF, Kaslow DC, Miller LH. Pathways and strategies for developing a malaria blood-stage vaccine. Annu Rev Immunol. 1998; 16:57-87. PMID: 9597124.
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    126. Bruno JM, Feachem R, Godal T, Nchinda T, Ogilvie B, Mons B, Mshana R, Radda G, Samba E, Schwartz M, Varmus H, Diallo S, Doumbo O, Greenwood B, Kilama W, Miller LH, da Silva LP. The spirit of Dakar: a call for action on malaria. Nature. 1997 Apr 10; 386(6625):541. PMID: 9121571.
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    127. Tian JH, Miller LH, Kaslow DC, Ahlers J, Good MF, Alling DW, Berzofsky JA, Kumar S. Genetic regulation of protective immune response in congenic strains of mice vaccinated with a subunit malaria vaccine. J Immunol. 1996 Aug 01; 157(3):1176-83. PMID: 8757623.
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