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Dr Christopher Schofield

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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hopkinson RJ, Leung IK, Smart TJ, Rose NR, Henry L, Claridge TD, Schofield CJ. Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans. PLoS One. 2015; 10(12):e0145085. PMID: 26675168; PMCID: PMC4682968.
    2. Emir UE, Larkin SJ, de Pennington N, Voets N, Plaha P, Stacey R, Al-Qahtani K, Mccullagh J, Schofield CJ, Clare S, Jezzard P, Cadoux-Hudson T, Ansorge O. Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations. Cancer Res. 2016 Jan 01; 76(1):43-9. PMID: 26669865; PMCID: PMC4704134.
    3. Kamps JJ, Khan A, Choi H, Lesniak RK, Brem J, Rydzik AM, McDonough MA, Schofield CJ, Claridge TD, Mecinovic J. Cation-p Interactions Contribute to Substrate Recognition in ?-Butyrobetaine Hydroxylase Catalysis. Chemistry. 2016 Jan 22; 22(4):1270-6. PMID: 26660433; PMCID: PMC4736438.
    4. Nazarov IB, Schofield CJ, Terrar DA. Contributions of cardiac "funny" (f) channels and sarcoplasmic reticulum Ca2+ in regulating beating rate of mouse and guinea pig sinoatrial node. Physiol Rep. 2015 Dec; 3(12). PMID: 26660545; PMCID: PMC4760437.
    5. Allerston CK, Lee SY, Newman JA, Schofield CJ, McHugh PJ, Gileadi O. The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities. Nucleic Acids Res. 2015 Dec 15; 43(22):11047-60. PMID: 26582912.
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    6. Thinnes CC, Tumber A, Yapp C, Scozzafava G, Yeh T, Chan MC, Tran TA, Hsu K, Tarhonskaya H, Walport LJ, Wilkins SE, Martinez ED, Müller S, Pugh CW, Ratcliffe PJ, Brennan PE, Kawamura A, Schofield CJ. Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases. Chem Commun (Camb). 2015 Oct 28; 51(84):15458-61. PMID: 26345662.
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    7. Brem J, van Berkel SS, Zollman D, Lee SY, Gileadi O, McHugh PJ, Walsh TR, McDonough MA, Schofield CJ. Structural Basis of Metallo-ß-Lactamase Inhibition by Captopril Stereoisomers. Antimicrob Agents Chemother. 2015 Oct 19; 60(1):142-50. PMID: 26482303; PMCID: PMC4704194.
    8. Longbotham JE, Levy C, Johannissen LO, Tarhonskaya H, Jiang S, Loenarz C, Flashman E, Hay S, Schofield CJ, Scrutton NS. Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase. Biochemistry. 2015 Oct 06; 54(39):6093-105. PMID: 26368022; PMCID: PMC4613865.
    9. Lercher L, Raj R, Patel NA, Price J, Mohammed S, Robinson CV, Schofield CJ, Davis BG. Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation. Nat Commun. 2015 Aug 25; 6:7978. PMID: 26305776; PMCID: PMC4560749.
    10. Domene C, Jorgensen C, Vanommeslaeghe K, Schofield CJ, MacKerell A. Quantifying the Binding Interaction between the Hypoxia-Inducible Transcription Factor and the von Hippel-Lindau Suppressor. J Chem Theory Comput. 2015 Aug 11; 11(8):3946-54. PMID: 26574473.
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    11. Al-Qahtani K, Jabeen B, Sekirnik R, Riaz N, Claridge TD, Schofield CJ, McCullagh JS. The broad spectrum 2-oxoglutarate oxygenase inhibitor N-oxalylglycine is present in rhubarb and spinach leaves. Phytochemistry. 2015 Sep; 117:456-61. PMID: 26196940.
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    12. Markolovic S, Wilkins SE, Schofield CJ. Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases. J Biol Chem. 2015 Aug 21; 290(34):20712-22. PMID: 26152730; PMCID: PMC4543633.
    13. Chan MC, Atasoylu O, Hodson E, Tumber A, Leung IK, Chowdhury R, Gómez-Pérez V, Demetriades M, Rydzik AM, Holt-Martyn J, Tian YM, Bishop T, Claridge TD, Kawamura A, Pugh CW, Ratcliffe PJ, Schofield CJ. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. PLoS One. 2015; 10(7):e0132004. PMID: 26147748; PMCID: PMC4492579.
    14. Ghavami A, Labbé G, Brem J, Goodfellow VJ, Marrone L, Tanner CA, King DT, Lam M, Strynadka NC, Pillai DR, Siemann S, Spencer J, Schofield CJ, Dmitrienko GI. Assay for drug discovery: Synthesis and testing of nitrocefin analogues for use as ß-lactamase substrates. Anal Biochem. 2015 Oct 01; 486:75-7. PMID: 26142222.
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    15. Plank M, Fischer R, Geoghegan V, Charles PD, Konietzny R, Acuto O, Pears C, Schofield CJ, Kessler BM. Expanding the yeast protein arginine methylome. Proteomics. 2015 Sep; 15(18):3232-43. PMID: 26046779.
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    16. Tarhonskaya H, Hardy AP, Howe EA, Loik ND, Kramer HB, McCullagh JS, Schofield CJ, Flashman E. Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor. J Biol Chem. 2015 Aug 07; 290(32):19726-42. PMID: 26112411; PMCID: PMC4528135.
    17. Dujardin JP, Pham Thi K, Truong Xuan L, Panzera F, Pita S, Schofield CJ. Epidemiological status of kissing-bugs in South East Asia: A preliminary assessment. Acta Trop. 2015 Nov; 151:142-9. PMID: 26115948.
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    18. Böttger A, Islam MS, Chowdhury R, Schofield CJ, Wolf A. The oxygenase Jmjd6--a case study in conflicting assignments. Biochem J. 2015 Jun 01; 468(2):191-202. PMID: 25997831.
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    19. McMurray F, Demetriades M, Aik W, Merkestein M, Kramer H, Andrew DS, Scudamore CL, Hough TA, Wells S, Ashcroft FM, McDonough MA, Schofield CJ, Cox RD. Pharmacological inhibition of FTO. PLoS One. 2015; 10(4):e0121829. PMID: 25830347; PMCID: PMC4382163.
    20. Dujardin JP, Lam TX, Khoa PT, Schofield CJ. The rising importance of Triatoma rubrofasciata. Mem Inst Oswaldo Cruz. 2015 May; 110(3):319-23. PMID: 25807471; PMCID: PMC4489469.
    21. Tan SC, Gomes RS, Yeoh KK, Perbellini F, Malandraki-Miller S, Ambrose L, Heather LC, Faggian G, Schofield CJ, Davies KE, Clarke K, Carr CA. Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism. Cell Transplant. 2016; 25(1):35-53. PMID: 25751158.
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    22. Horita S, Scotti JS, Thinnes C, Mottaghi-Taromsari YS, Thalhammer A, Ge W, Aik W, Loenarz C, Schofield CJ, McDonough MA. Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases. Structure. 2015 Apr 07; 23(4):639-52. PMID: 25728928; PMCID: PMC4396695.
    23. Zafred D, Steiner B, Teufelberger AR, Hromic A, Karplus PA, Schofield CJ, Wallner S, Macheroux P. Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction. FEBS J. 2015 Aug; 282(16):3060-74. PMID: 25619330.
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    24. Pettinati I, Brem J, McDonough MA, Schofield CJ. Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy. Hum Mol Genet. 2015 May 01; 24(9):2458-69. PMID: 25596185; PMCID: PMC4383860.
    25. Yufa R, Krylova SM, Bruce C, Bagg EA, Schofield CJ, Krylov SN. Emulsion PCR significantly improves nonequilibrium capillary electrophoresis of equilibrium mixtures-based aptamer selection: allowing for efficient and rapid selection of aptamer to unmodified ABH2 protein. Anal Chem. 2015 Jan 20; 87(2):1411-9. PMID: 25495441.
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    26. Williams ST, Walport LJ, Hopkinson RJ, Madden SK, Chowdhury R, Schofield CJ, Kawamura A. Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates. Epigenetics. 2014 Dec; 9(12):1596-603. PMID: 25625844; PMCID: PMC4623018.
    27. Brem J, van Berkel SS, Aik W, Rydzik AM, Avison MB, Pettinati I, Umland KD, Kawamura A, Spencer J, Claridge TD, McDonough MA, Schofield CJ. Rhodanine hydrolysis leads to potent thioenolate mediated metallo-ß-lactamase inhibition. Nat Chem. 2014 Dec; 6(12):1084-90. PMID: 25411887.
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    28. Michailidou Z, Morton NM, Moreno Navarrete JM, West CC, Stewart KJ, Fernández-Real JM, Schofield CJ, Seckl JR, Ratcliffe PJ. Adipocyte pseudohypoxia suppresses lipolysis and facilitates benign adipose tissue expansion. Diabetes. 2015 Mar; 64(3):733-45. PMID: 25377876.
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    29. Tarhonskaya H, Chowdhury R, Leung IK, Loik ND, McCullagh JS, Claridge TD, Schofield CJ, Flashman E. Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen. Biochem J. 2014 Nov 01; 463(3):363-72. PMID: 25120187.
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    30. Makena A, Brem J, Pfeffer I, Geffen RE, Wilkins SE, Tarhonskaya H, Flashman E, Phee LM, Wareham DW, Schofield CJ. Biochemical characterization of New Delhi metallo-ß-lactamase variants reveals differences in protein stability. J Antimicrob Chemother. 2015 Feb; 70(2):463-9. PMID: 25324420; PMCID: PMC4291237.
    31. Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM. Kruidenier et al. reply. Nature. 2014 Oct 02; 514(7520):E2. PMID: 25279927.
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    32. Rydzik AM, Brem J, Struwe WB, Kochan GT, Benesch JL, Schofield CJ. Ejection of structural zinc leads to inhibition of ?-butyrobetaine hydroxylase. Bioorg Med Chem Lett. 2014 Nov 01; 24(21):4954-7. PMID: 25266780.
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    33. Rydzik AM, Leung IK, Kochan GT, Loik ND, Henry L, McDonough MA, Claridge TD, Schofield CJ. Comparison of the substrate selectivity and biochemical properties of human and bacterial ?-butyrobetaine hydroxylase. Org Biomol Chem. 2014 Sep 07; 12(33):6354-8. PMID: 25030770.
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    34. Scotti JS, Leung IK, Ge W, Bentley MA, Paps J, Kramer HB, Lee J, Aik W, Choi H, Paulsen SM, Bowman LA, Loik ND, Horita S, Ho CH, Kershaw NJ, Tang CM, Claridge TD, Preston GM, McDonough MA, Schofield CJ. Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13331-6. PMID: 25197067; PMCID: PMC4169948.
    35. Rydzik AM, Leung IK, Kochan GT, McDonough MA, Claridge TD, Schofield CJ. Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids. Angew Chem Int Ed Engl. 2014 Oct 06; 53(41):10925-7. PMID: 25164544; PMCID: PMC4497603.
    36. Chen RL, Ogunshola OO, Yeoh KK, Jani A, Papadakis M, Nagel S, Schofield CJ, Buchan AM. HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice. J Neurochem. 2014 Oct; 131(2):177-89. PMID: 24974727.
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    37. Jayatunga MK, Thompson S, McKee TC, Chan MC, Reece KM, Hardy AP, Sekirnik R, Seden PT, Cook KM, McMahon JB, Figg WD, Schofield CJ, Hamilton AD. Inhibition of the HIF1a-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II). Eur J Med Chem. 2015 Apr 13; 94:509-16. PMID: 25023609; PMCID: PMC4277744.
    38. Hay DA, Fedorov O, Martin S, Singleton DC, Tallant C, Wells C, Picaud S, Philpott M, Monteiro OP, Rogers CM, Conway SJ, Rooney TP, Tumber A, Yapp C, Filippakopoulos P, Bunnage ME, Müller S, Knapp S, Schofield CJ, Brennan PE. Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains. J Am Chem Soc. 2014 Jul 02; 136(26):9308-19. PMID: 24946055; PMCID: PMC4183655.
    39. Heim A, Grimm C, Müller U, Häußler S, Mackeen MM, Merl J, Hauck SM, Kessler BM, Schofield CJ, Wolf A, Böttger A. Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine-serine-rich (RS) domains of SR- and SR-like proteins. Nucleic Acids Res. 2014 Jul; 42(12):7833-50. PMID: 24914048; PMCID: PMC4081092.
    40. Lu M, Zak J, Chen S, Sanchez-Pulido L, Severson DT, Endicott J, Ponting CP, Schofield CJ, Lu X. A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway. Cell. 2014 May 22; 157(5):1130-45. PMID: 24855949.
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    41. Thinnes CC, England KS, Kawamura A, Chowdhury R, Schofield CJ, Hopkinson RJ. Targeting histone lysine demethylases - progress, challenges, and the future. Biochim Biophys Acta. 2014 Dec; 1839(12):1416-32. PMID: 24859458; PMCID: PMC4316176.
    42. Chowdhury R, Sekirnik R, Brissett NC, Krojer T, Ho CH, Ng SS, Clifton IJ, Ge W, Kershaw NJ, Fox GC, Muniz JRC, Vollmar M, Phillips C, Pilka ES, Kavanagh KL, von Delft F, Oppermann U, McDonough MA, Doherty AJ, Schofield CJ. Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature. 2014 Jun 19; 510(7505):422-426. PMID: 24814345; PMCID: PMC4066111.
    43. Walport LJ, Hopkinson RJ, Vollmar M, Madden SK, Gileadi C, Oppermann U, Schofield CJ, Johansson C. Human UTY(KDM6C) is a male-specific N?-methyl lysyl demethylase. J Biol Chem. 2014 Jun 27; 289(26):18302-13. PMID: 24798337; PMCID: PMC4140284.
    44. Xu C, Liu K, Tempel W, Demetriades M, Aik W, Schofield CJ, Min J. Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. J Biol Chem. 2014 Jun 20; 289(25):17299-311. PMID: 24778178; PMCID: PMC4067165.
    45. Tarhonskaya H, Szöllössi A, Leung IK, Bush JT, Henry L, Chowdhury R, Iqbal A, Claridge TD, Schofield CJ, Flashman E. Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases. Biochemistry. 2014 Apr 22; 53(15):2483-93. PMID: 24684493.
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    46. Tarhonskaya H, Rydzik AM, Leung IK, Loik ND, Chan MC, Kawamura A, McCullagh JS, Claridge TD, Flashman E, Schofield CJ. Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases. Nat Commun. 2014 Mar 05; 5:3423. PMID: 24594748; PMCID: PMC3959194.
    47. Rydzik AM, Brem J, van Berkel SS, Pfeffer I, Makena A, Claridge TD, Schofield CJ. Monitoring conformational changes in the NDM-1 metallo-ß-lactamase by 19F NMR spectroscopy. Angew Chem Int Ed Engl. 2014 Mar 17; 53(12):3129-33. PMID: 24615874; PMCID: PMC4499255.
    48. Singleton RS, Liu-Yi P, Formenti F, Ge W, Sekirnik R, Fischer R, Adam J, Pollard PJ, Wolf A, Thalhammer A, Loenarz C, Flashman E, Yamamoto A, Coleman ML, Kessler BM, Wappner P, Schofield CJ, Ratcliffe PJ, Cockman ME. OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4031-6. PMID: 24550447; PMCID: PMC3964040.
    49. Loenarz C, Sekirnik R, Thalhammer A, Ge W, Spivakovsky E, Mackeen MM, McDonough MA, Cockman ME, Kessler BM, Ratcliffe PJ, Wolf A, Schofield CJ. Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4019-24. PMID: 24550462; PMCID: PMC3964080.
    50. Katz MJ, Acevedo JM, Loenarz C, Galagovsky D, Liu-Yi P, Pérez-Pepe M, Thalhammer A, Sekirnik R, Ge W, Melani M, Thomas MG, Simonetta S, Boccaccio GL, Schofield CJ, Cockman ME, Ratcliffe PJ, Wappner P. Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4025-30. PMID: 24550463; PMCID: PMC3964085.
    51. Snell CE, Turley H, McIntyre A, Li D, Masiero M, Schofield CJ, Gatter KC, Harris AL, Pezzella F. Proline-hydroxylated hypoxia-inducible factor 1a (HIF-1a) upregulation in human tumours. PLoS One. 2014; 9(2):e88955. PMID: 24563687; PMCID: PMC3923075.
    52. Rydzik AM, Leung IK, Thalhammer A, Kochan GT, Claridge TD, Schofield CJ. Fluoromethylated derivatives of carnitine biosynthesis intermediates--synthesis and applications. Chem Commun (Camb). 2014 Feb 07; 50(10):1175-7. PMID: 24317009.
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    53. Schiller R, Scozzafava G, Tumber A, Wickens JR, Bush JT, Rai G, Lejeune C, Choi H, Yeh TL, Chan MC, Mott BT, McCullagh JS, Maloney DJ, Schofield CJ, Kawamura A. A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem. 2014 Mar; 9(3):566-71. PMID: 24504543; PMCID: PMC4503230.
    54. Aik W, Scotti JS, Choi H, Gong L, Demetriades M, Schofield CJ, McDonough MA. Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. Nucleic Acids Res. 2014 Apr; 42(7):4741-54. PMID: 24489119; PMCID: PMC3985658.
    55. Feng T, Yamamoto A, Wilkins SE, Sokolova E, Yates LA, Münzel M, Singh P, Hopkinson RJ, Fischer R, Cockman ME, Shelley J, Trudgian DC, Schödel J, McCullagh JS, Ge W, Kessler BM, Gilbert RJ, Frolova LY, Alkalaeva E, Ratcliffe PJ, Schofield CJ, Coleman ML. Optimal translational termination requires C4 lysyl hydroxylation of eRF1. Mol Cell. 2014 Feb 20; 53(4):645-54. PMID: 24486019; PMCID: PMC3991326.
    56. Rotili D, Tomassi S, Conte M, Benedetti R, Tortorici M, Ciossani G, Valente S, Marrocco B, Labella D, Novellino E, Mattevi A, Altucci L, Tumber A, Yapp C, King ON, Hopkinson RJ, Kawamura A, Schofield CJ, Mai A. Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. J Med Chem. 2014 Jan 09; 57(1):42-55. PMID: 24325601.
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    57. Lercher L, McDonough MA, El-Sagheer AH, Thalhammer A, Kriaucionis S, Brown T, Schofield CJ. Structural insights into how 5-hydroxymethylation influences transcription factor binding. Chem Commun (Camb). 2014 Feb 21; 50(15):1794-6. PMID: 24287551.
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    58. Cherblanc FL, Chapman KL, Reid J, Borg AJ, Sundriyal S, Alcazar-Fuoli L, Bignell E, Demetriades M, Schofield CJ, DiMaggio PA, Brown R, Fuchter MJ. On the histone lysine methyltransferase activity of fungal metabolite chaetocin. J Med Chem. 2013 Nov 14; 56(21):8616-25. PMID: 24099080.
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    59. Makena A, van Berkel SS, Lejeune C, Owens RJ, Verma A, Salimraj R, Spencer J, Brem J, Schofield CJ. Chromophore-linked substrate (CLS405): probing metallo-ß-lactamase activity and inhibition. ChemMedChem. 2013 Dec; 8(12):1923-9. PMID: 24166830.
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    60. Hamed RB, Henry L, Gomez-Castellanos JR, Asghar A, Brem J, Claridge TD, Schofield CJ. Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase. Org Biomol Chem. 2013 Dec 21; 11(47):8191-6. PMID: 24108359.
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    61. Suzuki T, Ozasa H, Itoh Y, Zhan P, Sawada H, Mino K, Walport L, Ohkubo R, Kawamura A, Yonezawa M, Tsukada Y, Tumber A, Nakagawa H, Hasegawa M, Sasaki R, Mizukami T, Schofield CJ, Miyata N. Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J Med Chem. 2013 Sep 26; 56(18):7222-31. PMID: 23964788; PMCID: PMC3929130.
    62. van Berkel SS, Brem J, Rydzik AM, Salimraj R, Cain R, Verma A, Owens RJ, Fishwick CW, Spencer J, Schofield CJ. Assay platform for clinically relevant metallo-ß-lactamases. J Med Chem. 2013 Sep 12; 56(17):6945-53. PMID: 23898798; PMCID: PMC3910272.
    63. van Berkel SS, Nettleship JE, Leung IK, Brem J, Choi H, Stuart DI, Claridge TD, McDonough MA, Owens RJ, Ren J, Schofield CJ. Binding of (5S)-penicilloic acid to penicillin binding protein 3. ACS Chem Biol. 2013 Oct 18; 8(10):2112-6. PMID: 23899657.
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    64. Lercher L, McGouran JF, Kessler BM, Schofield CJ, Davis BG. DNA modification under mild conditions by Suzuki-Miyaura cross-coupling for the generation of functional probes. Angew Chem Int Ed Engl. 2013 Sep 27; 52(40):10553-8. PMID: 23943570; PMCID: PMC3823066.
    65. Wolf A, Mantri M, Heim A, Müller U, Fichter E, Mackeen MM, Schermelleh L, Dadie G, Leonhardt H, Vénien-Bryan C, Kessler BM, Schofield CJ, Böttger A. The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization. Biochem J. 2013 Aug 01; 453(3):357-70. PMID: 23688307.
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    66. Valegård K, Iqbal A, Kershaw NJ, Ivison D, Généreux C, Dubus A, Blikstad C, Demetriades M, Hopkinson RJ, Lloyd AJ, Roper DI, Schofield CJ, Andersson I, McDonough MA. Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway. Acta Crystallogr D Biol Crystallogr. 2013 Aug; 69(Pt 8):1567-79. PMID: 23897479.
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    67. Hopkinson RJ, Walport LJ, Münzel M, Rose NR, Smart TJ, Kawamura A, Claridge TD, Schofield CJ. Is JmjC oxygenase catalysis limited to demethylation? Angew Chem Int Ed Engl. 2013 Jul 22; 52(30):7709-13. PMID: 23788451; PMCID: PMC3798130.
    68. Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian YM, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A, Demetriades M, Mathavan S, Kawamura A, Lee MK, van Eeden F, Pugh CW, Ratcliffe PJ, Schofield CJ. Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol. 2013 Jul 19; 8(7):1488-96. PMID: 23683440.
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    69. Bishop T, Talbot NP, Turner PJ, Nicholls LG, Pascual A, Hodson EJ, Douglas G, Fielding JW, Smith TG, Demetriades M, Schofield CJ, Robbins PA, Pugh CW, Buckler KJ, Ratcliffe PJ. Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2. J Physiol. 2013 Jul 15; 591(14):3565-77. PMID: 23690557; PMCID: PMC3731614.
    70. Aik W, Demetriades M, Hamdan MK, Bagg EA, Yeoh KK, Lejeune C, Zhang Z, McDonough MA, Schofield CJ. Structural basis for inhibition of the fat mass and obesity associated protein (FTO). J Med Chem. 2013 May 09; 56(9):3680-8. PMID: 23547775.
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    71. Philip S, Howat I, Carson M, Booth A, Campbell K, Grant D, Patterson C, Schofield C, Bevan J, Patrick A, Leese G, Connell J. An audit of growth hormone replacement for GH-deficient adults in Scotland. Clin Endocrinol (Oxf). 2013 Apr; 78(4):571-6. PMID: 22901318.
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    72. Sarathi Addy P, Saha B, Pradeep Singh ND, Das AK, Bush JT, Lejeune C, Schofield CJ, Basak A. 1,3,5-Trisubstituted benzenes as fluorescent photoaffinity probes for human carbonic anhydrase II capture. Chem Commun (Camb). 2013 Mar 07; 49(19):1930-2. PMID: 23364467.
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    73. Sánchez-Fernández EM, Tarhonskaya H, Al-Qahtani K, Hopkinson RJ, McCullagh JS, Schofield CJ, Flashman E. Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase. Biochem J. 2013 Jan 15; 449(2):491-6. PMID: 23092293; PMCID: PMC4673901.
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    156. Inglis SR, Woon EC, Thompson AL, Schofield CJ. Observations on the deprotection of pinanediol and pinacol boronate esters via fluorinated intermediates. J Org Chem. 2010 Jan 15; 75(2):468-71. PMID: 20014787.
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    157. Yue WW, Hozjan V, Ge W, Loenarz C, Cooper CD, Schofield CJ, Kavanagh KL, Oppermann U, McDonough MA. Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase. FEBS Lett. 2010 Feb 19; 584(4):825-30. PMID: 20067792.
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    158. Hamed RB, Mecinovic J, Ducho C, Claridge TD, Schofield CJ. Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles. Chem Commun (Camb). 2010 Mar 07; 46(9):1413-5. PMID: 20162132.
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    159. Mackenzie AK, Valegård K, Iqbal A, Caines ME, Kershaw NJ, Jensen SE, Schofield CJ, Andersson I. Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid. J Mol Biol. 2010 Feb 19; 396(2):332-44. PMID: 19941870.
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    160. Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CD, Klose RJ, Ratcliffe PJ, Schofield CJ. PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. Hum Mol Genet. 2010 Jan 15; 19(2):217-22. PMID: 19843542; PMCID: PMC4673897.
    161. Sakurai M, Rose NR, Schultz L, Quinn AM, Jadhav A, Ng SS, Oppermann U, Schofield CJ, Simeonov A. A miniaturized screen for inhibitors of Jumonji histone demethylases. Mol Biosyst. 2010 Feb; 6(2):357-64. PMID: 20094655; PMCID: PMC3401096.
    162. Inglis SR, Zervosen A, Woon EC, Gerards T, Teller N, Fischer DS, Luxen A, Schofield CJ. Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. J Med Chem. 2009 Oct 08; 52(19):6097-106. PMID: 19731939.
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    163. Sekirnik R, Rose NR, Thalhammer A, Seden PT, Mecinovic J, Schofield CJ. Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II). Chem Commun (Camb). 2009 Nov 14; (42):6376-8. PMID: 19841782.
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    164. Mecinovic J, Loenarz C, Chowdhury R, Schofield CJ. 2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2. Bioorg Med Chem Lett. 2009 Nov 01; 19(21):6192-5. PMID: 19775891.
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    165. Church C, Lee S, Bagg EA, McTaggart JS, Deacon R, Gerken T, Lee A, Moir L, Mecinovic J, Quwailid MM, Schofield CJ, Ashcroft FM, Cox RD. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet. 2009 Aug; 5(8):e1000599. PMID: 19680540; PMCID: PMC2719869.
    166. Schofield CJ, Yu N, Jain AS, Leese GP. Decreasing amputation rates in patients with diabetes-a population-based study. Diabet Med. 2009 Aug; 26(8):773-7. PMID: 19709146.
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    167. Hardy AP, Prokes I, Kelly L, Campbell ID, Schofield CJ. Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function. J Mol Biol. 2009 Oct 02; 392(4):994-1006. PMID: 19646994.
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    168. Chowdhury R, McDonough MA, Mecinovic J, Loenarz C, Flashman E, Hewitson KS, Domene C, Schofield CJ. Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases. Structure. 2009 Jul 15; 17(7):981-9. PMID: 19604478.
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    169. Karkhanina AA, Mecinovic J, Musheev MU, Krylova SM, Petrov AP, Hewitson KS, Flashman E, Schofield CJ, Krylov SN. Direct analysis of enzyme-catalyzed DNA demethylation. Anal Chem. 2009 Jul 15; 81(14):5871-5. PMID: 19518090.
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    170. Cook KM, Hilton ST, Mecinovic J, Motherwell WB, Figg WD, Schofield CJ. Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism. J Biol Chem. 2009 Sep 25; 284(39):26831-8. PMID: 19589782; PMCID: PMC2785371.
    171. Webby CJ, Wolf A, Gromak N, Dreger M, Kramer H, Kessler B, Nielsen ML, Schmitz C, Butler DS, Yates JR, Delahunty CM, Hahn P, Lengeling A, Mann M, Proudfoot NJ, Schofield CJ, Böttger A. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Science. 2009 Jul 03; 325(5936):90-3. PMID: 19574390.
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    172. Mecinovic J, Chowdhury R, Flashman E, Schofield CJ. Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2. Anal Biochem. 2009 Oct 15; 393(2):215-21. PMID: 19563769.
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    173. Loenarz C, Schofield CJ. Oxygenase catalyzed 5-methylcytosine hydroxylation. Chem Biol. 2009 Jun 26; 16(6):580-3. PMID: 19549596.
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    174. Caines ME, Sorensen JL, Schofield CJ. Structural and mechanistic studies on N(2)-(2-carboxyethyl)arginine synthase. Biochem Biophys Res Commun. 2009 Aug 07; 385(4):512-7. PMID: 19477162.
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    175. Stubbs CJ, Loenarz C, Mecinovic J, Yeoh KK, Hindley N, Liénard BM, Sobott F, Schofield CJ, Flashman E. Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure. J Med Chem. 2009 May 14; 52(9):2799-805. PMID: 19364117.
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    176. Ducho C, Hamed RB, Batchelar ET, Sorensen JL, Odell B, Schofield CJ. Synthesis of regio- and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis. Org Biomol Chem. 2009 Jul 07; 7(13):2770-9. PMID: 19532994.
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    177. Schofield CJ, Galvão C. Classification, evolution, and species groups within the Triatominae. Acta Trop. 2009 May-Jun; 110(2-3):88-100. PMID: 19385053.
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    178. Hamed RB, Batchelar ET, Mecinovic J, Claridge TD, Schofield CJ. Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline. Chembiochem. 2009 Jan 26; 10(2):246-50. PMID: 19090510.
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    179. Iqbal A, Clifton IJ, Bagonis M, Kershaw NJ, Domene C, Claridge TD, Wharton CW, Schofield CJ. Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase. J Am Chem Soc. 2009 Jan 21; 131(2):749-57. PMID: 19105697.
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    180. Loenarz C, Mecinovic J, Chowdhury R, McNeill LA, Flashman E, Schofield CJ. Evidence for a stereoelectronic effect in human oxygen sensing. Angew Chem Int Ed Engl. 2009; 48(10):1784-7. PMID: 19180614.
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    181. Mecinovic J, Hamed RB, Schofield CJ. Iron-mediated cleavage of C-C bonds in vicinal tricarbonyl compounds in water. Angew Chem Int Ed Engl. 2009; 48(15):2796-800. PMID: 19280617.
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    182. Pollard PJ, Loenarz C, Mole DR, McDonough MA, Gleadle JM, Schofield CJ, Ratcliffe PJ. Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. Biochem J. 2008 Dec 15; 416(3):387-94. PMID: 18713068.
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    183. Plesa Skwerer D, Borum L, Verbalis A, Schofield C, Crawford N, Ciciolla L, Tager-Flusberg H. Autonomic responses to dynamic displays of facial expressions in adolescents and adults with Williams syndrome. Soc Cogn Affect Neurosci. 2009 Mar; 4(1):93-100. PMID: 19047076; PMCID: PMC2656881.
    184. Rose NR, Ng SS, Mecinovic J, Liénard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ. Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J Med Chem. 2008 Nov 27; 51(22):7053-6. PMID: 18942826.
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    185. Lienard BM, Conejo-García A, Stolze I, Loenarz C, Oldham NJ, Ratcliffe PJ, Schofield CJ. Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases. Chem Commun (Camb). 2008 Dec 21; (47):6393-5. PMID: 19048166.
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    186. Kelly L, McDonough MA, Coleman ML, Ratcliffe PJ, Schofield CJ. Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold. Mol Biosyst. 2009 Jan; 5(1):52-8. PMID: 19081931.
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    187. Kaewpet M, Odell B, King MA, Banerji B, Schofield CJ, Claridge TD. Synthesis and conformational analysis of cyclic analogues of inverse gamma-turns. Org Biomol Chem. 2008 Oct 07; 6(19):3476-85. PMID: 19082148.
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    188. Hamed RB, Batchelar ET, Clifton IJ, Schofield CJ. Mechanisms and structures of crotonase superfamily enzymes--how nature controls enolate and oxyanion reactivity. Cell Mol Life Sci. 2008 Aug; 65(16):2507-27. PMID: 18470480.
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    189. Schofield CJ, Kabayo JP. Trypanosomiasis vector control in Africa and Latin America. Parasit Vectors. 2008 Aug 01; 1(1):24. PMID: 18673535; PMCID: PMC2526077.
    190. Bleijlevens B, Shivarattan T, Flashman E, Yang Y, Simpson PJ, Koivisto P, Sedgwick B, Schofield CJ, Matthews SJ. Dynamic states of the DNA repair enzyme AlkB regulate product release. EMBO Rep. 2008 Sep; 9(9):872-7. PMID: 18617893; PMCID: PMC2529343.
    191. Hewitson KS, Holmes SL, Ehrismann D, Hardy AP, Chowdhury R, Schofield CJ, McDonough MA. Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH). J Biol Chem. 2008 Sep 19; 283(38):25971-8. PMID: 18611856; PMCID: PMC3258853.
    192. Chowdhury R, Hardy A, Schofield CJ. The human oxygen sensing machinery and its manipulation. Chem Soc Rev. 2008 Jul; 37(7):1308-19. PMID: 18568157.
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    193. Bargues MD, Klisiowicz DR, Gonzalez-Candelas F, Ramsey JM, Monroy C, Ponce C, Salazar-Schettino PM, Panzera F, Abad-Franch F, Sousa OE, Schofield CJ, Dujardin JP, Guhl F, Mas-Coma S. Phylogeography and genetic variation of Triatoma dimidiata, the main Chagas disease vector in Central America, and its position within the genus Triatoma. PLoS Negl Trop Dis. 2008 May 07; 2(5):e233. PMID: 18461141; PMCID: PMC2330091.
    194. Liénard BM, Garau G, Horsfall L, Karsisiotis AI, Damblon C, Lassaux P, Papamicael C, Roberts GC, Galleni M, Dideberg O, Frère JM, Schofield CJ. Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols. Org Biomol Chem. 2008 Jul 07; 6(13):2282-94. PMID: 18563261.
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    195. Mecinovic J, Chowdhury R, Liénard BM, Flashman E, Buck MR, Oldham NJ, Schofield CJ. ESI-MS studies on prolyl hydroxylase domain 2 reveal a new metal binding site. ChemMedChem. 2008 Apr; 3(4):569-72. PMID: 18058781.
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    196. Schofield C. Mental Capacity Act 2005--what do doctors know? Med Sci Law. 2008 Apr; 48(2):113-6. PMID: 18533570.
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    197. Loenarz C, Schofield CJ. Expanding chemical biology of 2-oxoglutarate oxygenases. Nat Chem Biol. 2008 Mar; 4(3):152-6. PMID: 18277970.
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    198. Chopra I, Schofield C, Everett M, O'Neill A, Miller K, Wilcox M, Frère JM, Dawson M, Czaplewski L, Urleb U, Courvalin P. Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement. Lancet Infect Dis. 2008 Feb; 8(2):133-9. PMID: 18222164.
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    199. Liénard BM, Hüting R, Lassaux P, Galleni M, Frère JM, Schofield CJ. Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors. J Med Chem. 2008 Feb 14; 51(3):684-8. PMID: 18205296.
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    200. Schofield CJ, Ellis JD, Ellingford A, Morris AD, Leese GP. Macular oedema is not predicted by perifoveal single blot haemorrhages. Diabet Med. 2008 Feb; 25(2):129-33. PMID: 18201214.
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    201. Batchelar ET, Hamed RB, Ducho C, Claridge TD, Edelmann MJ, Kessler B, Schofield CJ. Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily. Angew Chem Int Ed Engl. 2008; 47(48):9322-5. PMID: 18972478.
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    202. Flashman E, Bagg EA, Chowdhury R, Mecinovic J, Loenarz C, McDonough MA, Hewitson KS, Schofield CJ. Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases. J Biol Chem. 2008 Feb 15; 283(7):3808-15. PMID: 18063574.
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    203. Hazrati A, Ramis-Castelltort M, Sarkar S, Barber LJ, Schofield CJ, Hartley JA, McHugh PJ. Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants. DNA Repair (Amst). 2008 Feb 01; 7(2):230-8. PMID: 18006388.
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    204. Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science. 2007 Nov 30; 318(5855):1469-72. PMID: 17991826; PMCID: PMC2668859.
    205. Schofield CJ, McDonough MA. Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH). Biochem Soc Trans. 2007 Nov; 35(Pt 5):870-5. PMID: 17956235.
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    206. Macheboeuf P, Fischer DS, Brown T, Zervosen A, Luxen A, Joris B, Dessen A, Schofield CJ. Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. Nat Chem Biol. 2007 Sep; 3(9):565-9. PMID: 17676039.
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    207. Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U. Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature. 2007 Jul 05; 448(7149):87-91. PMID: 17589501.
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    208. Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J Biol Chem. 2007 Aug 17; 282(33):24027-38. PMID: 17573339.
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    209. Leese G, Schofield C, McMurray B, Libby G, Golden J, MacAlpine R, Cunningham S, Morris A, Flett M, Griffiths G. Scottish foot ulcer risk score predicts foot ulcer healing in a regional specialist foot clinic. Diabetes Care. 2007 Aug; 30(8):2064-9. PMID: 17519428.
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    210. Schofield C, Holden N. Detention on a general ward: understanding and applying the law. Br J Hosp Med (Lond). 2007 Mar; 68(3):152-4. PMID: 17419470.
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    211. Borowski T, de Marothy S, Broclawik E, Schofield CJ, Siegbahn PE. Mechanism for cyclization reaction by clavaminic acid synthase. Insights from modeling studies. Biochemistry. 2007 Mar 27; 46(12):3682-91. PMID: 17323933.
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    212. Horsfall LE, Garau G, Liénard BM, Dideberg O, Schofield CJ, Frère JM, Galleni M. Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila. Antimicrob Agents Chemother. 2007 Jun; 51(6):2136-42. PMID: 17307979; PMCID: PMC1891371.
    213. Flashman E, Schofield CJ. The most versatile of all reactive intermediates? Nat Chem Biol. 2007 Feb; 3(2):86-7. PMID: 17235343.
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    214. Liénard BM, Selevsek N, Oldham NJ, Schofield CJ. Combined mass spectrometry and dynamic chemistry approach to identify metalloenzyme inhibitors. ChemMedChem. 2007 Feb; 2(2):175-9. PMID: 17206734.
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    215. MacKenzie AK, Kershaw NJ, Hernandez H, Robinson CV, Schofield CJ, Andersson I. Clavulanic acid dehydrogenase: structural and biochemical analysis of the final step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid. Biochemistry. 2007 Feb 13; 46(6):1523-33. PMID: 17279617.
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    216. Hewitson KS, Schofield CJ, Ratcliffe PJ. Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2. Methods Enzymol. 2007; 435:25-42. PMID: 17998047.
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    217. Ehrismann D, Flashman E, Genn DN, Mathioudakis N, Hewitson KS, Ratcliffe PJ, Schofield CJ. Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. Biochem J. 2007 Jan 01; 401(1):227-34. PMID: 16952279; PMCID: PMC1698668.
    218. Hewitson KS, Liénard BM, McDonough MA, Clifton IJ, Butler D, Soares AS, Oldham NJ, McNeill LA, Schofield CJ. Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates. J Biol Chem. 2007 Feb 02; 282(5):3293-301. PMID: 17135241.
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    219. Bassan A, Borowski T, Schofield CJ, Siegbahn PE. Ethylene biosynthesis by 1-aminocyclopropane-1-carboxylic acid oxidase: a DFT study. Chemistry. 2006 Nov 24; 12(34):8835-46. PMID: 16933342.
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    220. Liénard BM, Horsfall LE, Galleni M, Frère JM, Schofield CJ. Inhibitors of the FEZ-1 metallo-beta-lactamase. Bioorg Med Chem Lett. 2007 Feb 15; 17(4):964-8. PMID: 17157014.
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    221. Schofield CJ, Jannin J, Salvatella R. The future of Chagas disease control. Trends Parasitol. 2006 Dec; 22(12):583-8. PMID: 17049308.
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    222. Schofield CJ, Libby G, Brennan GM, MacAlpine RR, Morris AD, Leese GP. Mortality and hospitalization in patients after amputation: a comparison between patients with and without diabetes. Diabetes Care. 2006 Oct; 29(10):2252-6. PMID: 17003302.
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    223. Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci U S A. 2006 Oct 03; 103(40):14767-72. PMID: 17003112; PMCID: PMC1578504.
    224. Schofield CJ, Zigmond T. Section 5(2) Mental Health Act 1983: does teaching make a difference? Med Sci Law. 2006 Jul; 46(3):229-32. PMID: 16909645.
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    225. McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Liénard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, Syed RS, Schofield CJ. Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). Proc Natl Acad Sci U S A. 2006 Jun 27; 103(26):9814-9. PMID: 16782814; PMCID: PMC1502536.
    226. Liu B, Schofield CJ, Wilmouth RC. Structural analyses on intermediates in serine protease catalysis. J Biol Chem. 2006 Aug 18; 281(33):24024-35. PMID: 16754679.
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    227. Selevsek N, Tholey A, Heinzle E, Liénard BM, Oldham NJ, Schofield CJ, Heinz U, Adolph HW, Frère JM. Studies on ternary metallo-beta lactamase-inhibitor complexes using electrospray ionization mass spectrometry. J Am Soc Mass Spectrom. 2006 Jul; 17(7):1000-4. PMID: 16713713.
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    228. Borowski T, Broclawik E, Schofield CJ, Siegbahn PE. Epimerization and desaturation by carbapenem synthase (CarC). A hybrid DFT study. J Comput Chem. 2006 Apr 30; 27(6):740-8. PMID: 16521121.
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    229. Clifton IJ, McDonough MA, Ehrismann D, Kershaw NJ, Granatino N, Schofield CJ. Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. J Inorg Biochem. 2006 Apr; 100(4):644-69. PMID: 16513174.
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    230. Murray-Rust TA, Oldham NJ, Hewitson KS, Schofield CJ. Purified recombinant hARD1 does not catalyse acetylation of Lys532 of HIF-1alpha fragments in vitro. FEBS Lett. 2006 Apr 03; 580(8):1911-8. PMID: 16500650.
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    231. Dias JC, Schofield CJ, Machado EM, Fernandes AJ. Ticks, ivermectin, and experimental Chagas disease. Mem Inst Oswaldo Cruz. 2005 Dec; 100(8):829-32. PMID: 16444412.
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    232. Arulanantham H, Kershaw NJ, Hewitson KS, Hughes CE, Thirkettle JE, Schofield CJ. ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid. J Biol Chem. 2006 Jan 06; 281(1):279-87. PMID: 16251194.
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    233. Banerji B, Conejo-Garcia A, McNeill LA, McDonough MA, Buck MR, Hewitson KS, Oldham NJ, Schofield CJ. The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids. Chem Commun (Camb). 2005 Nov 21; (43):5438-40. PMID: 16261239.
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    234. Welford RW, Kirkpatrick JM, McNeill LA, Puri M, Oldham NJ, Schofield CJ. Incorporation of oxygen into the succinate co-product of iron(II) and 2-oxoglutarate dependent oxygenases from bacteria, plants and humans. FEBS Lett. 2005 Sep 26; 579(23):5170-4. PMID: 16153644.
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    235. McDonough MA, Kavanagh KL, Butler D, Searls T, Oppermann U, Schofield CJ. Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease. J Biol Chem. 2005 Dec 09; 280(49):41101-10. PMID: 16186124.
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    236. Conejo-Garcia A, Schofield CJ. A prodrug system for hydroxylamines based on esterase catalysis. Bioorg Med Chem Lett. 2005 Sep 15; 15(18):4004-9. PMID: 15990293.
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    237. Schofield CJ. 21 years of parasitology. Trends Parasitol. 2005 Nov; 21(11):483-5. PMID: 16143566.
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    238. Schofield CJ, Ratcliffe PJ. Signalling hypoxia by HIF hydroxylases. Biochem Biophys Res Commun. 2005 Dec 09; 338(1):617-26. PMID: 16139242.
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    239. McNeill LA, Flashman E, Buck MR, Hewitson KS, Clifton IJ, Jeschke G, Claridge TD, Ehrismann D, Oldham NJ, Schofield CJ. Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate. Mol Biosyst. 2005 Oct; 1(4):321-4. PMID: 16880998.
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    240. Sleeman MC, Sorensen JL, Batchelar ET, McDonough MA, Schofield CJ. Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis. J Biol Chem. 2005 Oct 14; 280(41):34956-65. PMID: 16096274.
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    241. Kershaw NJ, Caines ME, Sleeman MC, Schofield CJ. The enzymology of clavam and carbapenem biosynthesis. Chem Commun (Camb). 2005 Sep 14; (34):4251-63. PMID: 16113715.
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    242. Welford RW, Clifton IJ, Turnbull JJ, Wilson SC, Schofield CJ. Structural and mechanistic studies on anthocyanidin synthase catalysed oxidation of flavanone substrates: the effect of C-2 stereochemistry on product selectivity and mechanism. Org Biomol Chem. 2005 Sep 07; 3(17):3117-26. PMID: 16106293.
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    243. McDonough MA, McNeill LA, Tilliet M, Papamicaël CA, Chen QY, Banerji B, Hewitson KS, Schofield CJ. Selective inhibition of factor inhibiting hypoxia-inducible factor. J Am Chem Soc. 2005 Jun 01; 127(21):7680-1. PMID: 15913349.
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    244. Searls T, Butler D, Chien W, Mukherji M, Lloyd MD, Schofield CJ. Studies on the specificity of unprocessed and mature forms of phytanoyl-CoA 2-hydroxylase and mutation of the iron binding ligands. J Lipid Res. 2005 Aug; 46(8):1660-7. PMID: 15930519.
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    245. Long AJ, Clifton IJ, Roach PL, Baldwin JE, Rutledge PJ, Schofield CJ. Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine. Biochemistry. 2005 May 03; 44(17):6619-28. PMID: 15850395.
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    338. Wright PA, Rostom AA, Robinson CV, Schofield CJ. Mass spectrometry reveals elastase inhibitors from the reactive centre loop of alpha1-antitrypsin. Bioorg Med Chem Lett. 2000 Jun 05; 10(11):1219-21. PMID: 10866385.
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    339. Diotaiuti L, Penido CM, Araújo HS, Schofield CJ, Pinto CT. Excito-repellency effect of deltamethrin on triatomines under laboratory conditions. Rev Soc Bras Med Trop. 2000 May-Jun; 33(3):247-52. PMID: 10967592.
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    340. Monteiro FA, Wesson DM, Dotson EM, Schofield CJ, Beard CB. Phylogeny and molecular taxonomy of the Rhodniini derived from mitochondrial and nuclear DNA sequences. Am J Trop Med Hyg. 2000 Apr; 62(4):460-5. PMID: 11220761.
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    341. Zhang Z, Ren J, Stammers DK, Baldwin JE, Harlos K, Schofield CJ. Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase. Nat Struct Biol. 2000 Feb; 7(2):127-33. PMID: 10655615.
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    342. Lee HJ, Lloyd MD, Harlos K, Schofield CJ. The effect of cysteine mutations on recombinant deacetoxycephalosporin C synthase from S. clavuligerus. Biochem Biophys Res Commun. 2000 Jan 07; 267(1):445-8. PMID: 10623639.
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    343. Diotaiuti L, Faria Filho OF, Carneiro FC, Dias JC, Pires HH, Schofield CJ. [Operational aspects of Triatoma brasiliensis control]. Cad Saude Publica. 2000; 16 Suppl 2:61-7. PMID: 11119320.
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    344. Schofield CJ. Biosystematics and evolution of the Triatominae. Cad Saude Publica. 2000; 16 Suppl 2:89-92. PMID: 11119324.
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    345. Panzera F, Pérez R, Nicolini P, Hornos S, Costa J, Borges E, Diotaiuti L, Schofield CJ. Chromosome homogeneity in populations of Triatoma brasiliensis Neiva 1911 (Hemiptera - reduviidae - triatominae). Cad Saude Publica. 2000; 16 Suppl 2:83-8. PMID: 11119323.
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    346. Schofield CJ, Zhang Z. Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes. Curr Opin Struct Biol. 1999 Dec; 9(6):722-31. PMID: 10607676.
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    347. Schofield CJ, Dujardin JP. Malaria: growth and selection. Parasitol Today. 1999 Nov; 15(11):466. PMID: 10511736.
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    348. Dujardin JP, Chavez T, Moreno JM, Machane M, Noireau F, Schofield CJ. Comparison of isoenzyme electrophoresis and morphometric analysis for phylogenetic reconstruction of the Rhodniini (Hemiptera: Reduviidae: Triatominae). J Med Entomol. 1999 Nov; 36(6):653-9. PMID: 10593062.
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    349. Dujardin J, Steinden M, Chavez T, Machane M, Schofield C. Changes in the sexual dimorphism of triatominae in the transition from natural to artificial habitats. Mem Inst Oswaldo Cruz. 1999 Jul-Aug; 94(4):565-9. PMID: 10446020.
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    350. Wilmouth RC, Kassamally S, Westwood NJ, Sheppard RJ, Claridge TD, Aplin RT, Wright PA, Pritchard GJ, Schofield CJ. Mechanistic insights into the inhibition of serine proteases by monocyclic lactams. Biochemistry. 1999 Jun 22; 38(25):7989-98. PMID: 10387042.
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    351. Lloyd MD, Lee HJ, Harlos K, Zhang ZH, Baldwin JE, Schofield CJ, Charnock JM, Garner CD, Hara T, Terwisscha van Scheltinga AC, Valegård K, Viklund JA, Hajdu J, Andersson I, Danielsson A, Bhikhabhai R. Studies on the active site of deacetoxycephalosporin C synthase. J Mol Biol. 1999 Apr 16; 287(5):943-60. PMID: 10222202.
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    352. Soares RP, Barbosa SE, Dujardin JP, Schofield CJ, Siqueira AM, Diotaiuti L. Characterization of Rhodnius neglectus from two regions of Brazil using isoenzymes, genitalia morphology and morphometry. Mem Inst Oswaldo Cruz. 1999 Mar-Apr; 94(2):161-6. PMID: 10224521.
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    353. Monteiro FA, Pérez R, Panzera F, Dujardin JP, Galvão C, Rocha D, Noireau F, Schofield C, Beard CB. Mitochondrial DNA variation of Triatoma infestans populations and its implication on the specific status of T. melanosoma. Mem Inst Oswaldo Cruz. 1999; 94 Suppl 1:229-38. PMID: 10677723.
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    354. Schofield CJ, Diotaiuti L, Dujardin JP. The process of domestication in Triatominae. Mem Inst Oswaldo Cruz. 1999; 94 Suppl 1:375-8. PMID: 10677759.
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    355. Dias J, Schofield C. The evolution of Chagas disease (American trypanosomiasis) control after 90 years since Carlos Chagas discovery. Mem Inst Oswaldo Cruz. 1999; 94 Suppl 1:103-21. PMID: 10677697.
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    356. Dujardin JP, Panzera P, Schofield CJ. Triatominae as a model of morphological plasticity under ecological pressure. Mem Inst Oswaldo Cruz. 1999; 94 Suppl 1:223-8. PMID: 10677722.
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    357. Schofield CJ, Dias JC. The Southern Cone Initiative against Chagas disease. Adv Parasitol. 1999; 42:1-27. PMID: 10050271.
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    358. Wilmouth RC, Westwood NJ, Anderson K, Brownlee W, Claridge TD, Clifton IJ, Pritchard GJ, Aplin RT, Schofield CJ. Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex. Biochemistry. 1998 Dec 15; 37(50):17506-13. PMID: 9860865.
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    359. Valegård K, van Scheltinga AC, Lloyd MD, Hara T, Ramaswamy S, Perrakis A, Thompson A, Lee HJ, Baldwin JE, Schofield CJ, Hajdu J, Andersson I. Structure of a cephalosporin synthase. Nature. 1998 Aug 20; 394(6695):805-9. PMID: 9723623.
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    360. Dias JC, Schofield CJ. [The control of the transmission by transfusion of Chagas' disease in the Southern Cone Initiative]. Rev Soc Bras Med Trop. 1998 Jul-Aug; 31(4):373-83. PMID: 9662965.
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    361. Basombrío MA, Schofield CJ, Rojas CL, del Rey EC. A cost-benefit analysis of Chagas disease control in north-western Argentina. Trans R Soc Trop Med Hyg. 1998 Mar-Apr; 92(2):137-43. PMID: 9764315.
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    362. Guarneri AA, Pinto CJ, Schofield CJ, Steindel M. Population biology of Rhodnius domesticus Neiva & Pinto, 1923 (Hemiptera: Reduviidae) under laboratory conditions. Mem Inst Oswaldo Cruz. 1998 Mar-Apr; 93(2):273-6. PMID: 9698908.
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    363. Schofield CJ, Apt W, Sagua H, Panzera F, Dujardin JP. Alary polymorphism in Triatoma spinolai and its possible relationship with demographic strategy. Med Vet Entomol. 1998 Jan; 12(1):30-8. PMID: 9513936.
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    364. Dujardin JP, Muñoz M, Chavez T, Ponce C, Moreno J, Schofield CJ. The origin of Rhodnius prolixus in Central America. Med Vet Entomol. 1998 Jan; 12(1):113-5. PMID: 9580149.
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    365. Dujardin JP, Schofield CJ, Tibayrenc M. Population structure of Andean Triatoma infestans: allozyme frequencies and their epidemiological relevance. Med Vet Entomol. 1998 Jan; 12(1):20-9. PMID: 9513935.
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    366. Garcia AL, Carrasco HJ, Schofield CJ, Stothard JR, Frame IA, Valente SA, Miles MA. Random amplification of polymorphic DNA as a tool for taxonomic studies of triatomine bugs (Hemiptera: Reduviidae). J Med Entomol. 1998 Jan; 35(1):38-45. PMID: 9542343.
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    367. Zhang Z, Barlow JN, Baldwin JE, Schofield CJ. Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidase. Biochemistry. 1997 Dec 16; 36(50):15999-6007. PMID: 9398335.
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    368. Schofield CJ, Baldwin JE, Byford MF, Clifton I, Hajdu J, Hensgens C, Roach P. Proteins of the penicillin biosynthesis pathway. Curr Opin Struct Biol. 1997 Dec; 7(6):857-64. PMID: 9434907.
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    369. Dujardin JP, Bermudez H, Schofield CJ. The use of morphometrics in entomological surveillance of sylvatic foci of Triatoma infestans in Bolivia. Acta Trop. 1997 Sep 10; 66(3):145-53. PMID: 9210965.
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    370. Dujardin JP, Bermudez H, Casini C, Schofield CJ, Tibayrenc M. Metric differences between silvatic and domestic Triatoma infestans (Heteroptera: Reduviidae) in Bolivia. J Med Entomol. 1997 Sep; 34(5):544-51. PMID: 9379460.
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    371. Baggaley KH, Brown AG, Schofield CJ. Chemistry and biosynthesis of clavulanic acid and other clavams. Nat Prod Rep. 1997 Aug; 14(4):309-33. PMID: 9281835.
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    372. Shiau CY, Byford MF, Aplin RT, Baldwin JE, Schofield CJ. L-delta-(alpha-Aminoadipoyl)-L-cysteinyl-D-valine synthetase: thioesterification of valine is not obligatory for peptide bond formation. Biochemistry. 1997 Jul 22; 36(29):8798-806. PMID: 9220966.
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    373. Roach PL, Clifton IJ, Hensgens CM, Shibata N, Schofield CJ, Hajdu J, Baldwin JE. Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation. Nature. 1997 Jun 19; 387(6635):827-30. PMID: 9194566.
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    374. Wilmouth RC, Clifton IJ, Robinson CV, Roach PL, Aplin RT, Westwood NJ, Hajdu J, Schofield CJ. Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase. Nat Struct Biol. 1997 Jun; 4(6):456-62. PMID: 9187653.
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    375. Schofield CJ, Dujardin JP. Chagas disease vector control in Central America. Parasitol Today. 1997 Apr; 13(4):141-4. PMID: 15275100.
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    376. Barlow JN, Zhang Z, John P, Baldwin JE, Schofield CJ. Inactivation of 1-aminocyclopropane-1-carboxylate oxidase involves oxidative modifications. Biochemistry. 1997 Mar 25; 36(12):3563-9. PMID: 9132007.
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    377. Sami M, Brown TJ, Roach PL, Schofield CJ, Baldwin JE. Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans. FEBS Lett. 1997 Mar 24; 405(2):191-4. PMID: 9089289.
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    378. Brown RP, Aplin RT, Schofield CJ, Frydrych CH. Mass spectrometric studies on the inhibition of TEM-2 beta-lactamase by clavulanic acid derivatives. J Antibiot (Tokyo). 1997 Feb; 50(2):184-5. PMID: 9099233.
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    379. Barlow JN, Baldwin JE, Clifton IJ, Gibson E, Hensgens CM, Hajdu J, Hara T, Hassan A, John P, Lloyd MD, Roach PL, Prescott A, Robinson JK, Zhang ZH, Schofield CJ. Studies on non-haem ferrous-dependent oxygenases and oxidases. Biochem Soc Trans. 1997 Feb; 25(1):86-90. PMID: 9056849.
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    380. Gorla DE, Dujardin JP, Schofield CJ. Biosystematics of Old World Triatominae. Acta Trop. 1997 Feb; 63(2-3):127-40. PMID: 9088426.
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    381. Guillen G, Diaz R, Jemio A, Cassab JA, Pinto CT, Schofield CJ. Chagas disease vector control in Tupiza, southern Bolivia. Mem Inst Oswaldo Cruz. 1997 Jan-Feb; 92(1):1-8. PMID: 9302405.
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    382. Roach PL, Clifton IJ, Hensgens CM, Shibata N, Long AJ, Strange RW, Hasnain SS, Schofield CJ, Baldwin JE, Hajdu J. Anaerobic crystallisation of an isopenicillin N synthase.Fe(II).substrate complex demonstrated by X-ray studies. Eur J Biochem. 1996 Dec 15; 242(3):736-40. PMID: 9022704.
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    383. Brown RP, Aplin RT, Schofield CJ. Inhibition of TEM-2 beta-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionization mass spectrometry. Biochemistry. 1996 Sep 24; 35(38):12421-32. PMID: 8823177.
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    384. Rees DC, Rochette J, Schofield C, Green B, Morris M, Parker NE, Sasaki H, Tanaka A, Ohba Y, Clegg JB. A novel silent posttranslational mechanism converts methionine to aspartate in hemoglobin Bristol (beta 67[E11] Val-Met->Asp). Blood. 1996 Jul 01; 88(1):341-8. PMID: 8704193.
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    385. Dujardin JP, Cardozo L, Schofield C. Genetic analysis of Triatoma infestans following insecticidal control interventions in central Bolivia. Acta Trop. 1996 May; 61(3):263-6. PMID: 8790776.
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    386. Schofield C, Ashworth A. Why have mortality rates for severe malnutrition remained so high? Bull World Health Organ. 1996; 74(2):223-9. PMID: 8706239; PMCID: PMC2486901.
    387. Lawrence CC, Sobey WJ, Field RA, Baldwin JE, Schofield CJ. Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis. Biochem J. 1996 Jan 01; 313 ( Pt 1):185-91. PMID: 8546682; PMCID: PMC1216881.
    388. Shiau CY, Byford MF, Baldwin JE, Schofield CJ. Molecular mechanism of the multifunctional enzyme L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine (ACV) synthetase. Biochem Soc Trans. 1995 Nov; 23(4):629S. PMID: 8654814.
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    389. Shiau CY, Baldwin JE, Byford MF, Schofield CJ. Delta-L-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase: isolation of L-cysteinyl-D-valine, a 'shunt' product, and implications for the order of peptide bond formation. FEBS Lett. 1995 Oct 16; 373(3):303-6. PMID: 7589488.
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    390. Roach PL, Clifton IJ, Fülöp V, Harlos K, Barton GJ, Hajdu J, Andersson I, Schofield CJ, Baldwin JE. Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes. Nature. 1995 Jun 22; 375(6533):700-4. PMID: 7791906.
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    391. Roach PL, Schofield CJ, Baldwin JE, Clifton IJ, Hajdu J. Crystallization and preliminary X-ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans. Protein Sci. 1995 May; 4(5):1007-9. PMID: 7663335; PMCID: PMC2143123.
    392. Zhang Z, Schofield CJ, Baldwin JE, Thomas P, John P. Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli. Biochem J. 1995 Apr 01; 307 ( Pt 1):77-85. PMID: 7717997; PMCID: PMC1136747.
    393. Shiau CY, Baldwin JE, Byford MF, Sobey WJ, Schofield CJ. delta-L-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase: the order of peptide bond formation and timing of the epimerisation reaction. FEBS Lett. 1995 Jan 16; 358(1):97-100. PMID: 7821439.
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    394. Fujishima Y, Nordlund P, Pelosi G, Schofield CJ, Cole SJ, Baldwin JE, Hajdu J. Crystallization and preliminary X-ray diffraction studies on a recombinant isopenicillin N synthase from Cephalosporium acremonium. J Mol Biol. 1994 Oct 07; 242(5):712-4. PMID: 7932729.
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    395. Baldwin JE, Shiau CY, Byford MF, Schofield CJ. Substrate specificity of L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase from Cephalosporium acremonium: demonstration of the structure of several unnatural tripeptide products. Biochem J. 1994 Jul 15; 301 ( Pt 2):367-72. PMID: 8042979; PMCID: PMC1137089.
    396. Baldwin JE, Claridge TD, Hulme C, Rodger A, Schofield CJ. Comments on the use of a dichromophoric circular dichroism assay for the identification of beta-turns in peptides. Int J Pept Protein Res. 1994 Feb; 43(2):180-3. PMID: 8200737.
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    397. Aplin RT, Baldwin JE, Roach PL, Robinson CV, Schofield CJ. Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry. Biochem J. 1993 Sep 01; 294 ( Pt 2):357-63. PMID: 8396910; PMCID: PMC1134462.
    398. Randall CR, Zang Y, True AE, Que L, Charnock JM, Garner CD, Fujishima Y, Schofield CJ, Baldwin JE. X-ray absorption studies of the ferrous active site of isopenicillin N synthase and related model complexes. Biochemistry. 1993 Jul 06; 32(26):6664-73. PMID: 8329393.
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    399. Gorla DE, Jurberg J, Catalá SS, Schofield CJ. Systematics of Triatoma sordida, T. guasayana and T. patagonica (Hemiptera, Reduviidae). Mem Inst Oswaldo Cruz. 1993 Jul-Sep; 88(3):379-85. PMID: 8107601.
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    400. Lehane MJ, McEwen PK, Whitaker CJ, Schofield CJ. The role of temperature and nutritional status in flight initiation by Triatoma infestans. Acta Trop. 1992 Sep; 52(1):27-38. PMID: 1359758.
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    401. Baldwin JE, Goh KC, Schofield CJ. Oxidation of deacetylcephalosporin C by deacetoxycephalosporin C/deacetylcephalosporin C synthase. J Antibiot (Tokyo). 1992 Aug; 45(8):1378-81. PMID: 1399861.
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    402. Schofield CJ, Lehane MJ, McEwen P, Catala SS, Gorla DE. Dispersive flight by Triatoma infestans under natural climatic conditions in Argentina. Med Vet Entomol. 1992 Jan; 6(1):51-6. PMID: 1600228.
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    403. Schofield CJ. Eradication of Triatoma infestans: a new regional programme for southern Latin America. Ann Soc Belg Med Trop. 1992; 72 Suppl 1:69-70. PMID: 1417170.
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    404. Schofield CJ, Lehane MJ, McEwan P, Catalá SS, Gorla DE. Dispersive flight by Triatoma sordida. Trans R Soc Trop Med Hyg. 1991 Sep-Oct; 85(5):676-8. PMID: 1781007.
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    405. Dujardin JP, Garcia-Zapata MT, Jurberg J, Roelants P, Cardozo L, Panzera F, Dias JC, Schofield CJ. Which species of Rhodnius is invading houses in Brazil? Trans R Soc Trop Med Hyg. 1991 Sep-Oct; 85(5):679-80. PMID: 1781008.
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    406. Schofield CJ, Dias JC. A cost-benefit analysis of Chagas disease control. Mem Inst Oswaldo Cruz. 1991 Jul-Sep; 86(3):285-95. PMID: 1842419.
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    407. Baldwin JE, Bird JW, Field RA, O'Callaghan NM, Schofield CJ, Willis AC. Isolation and partial characterisation of ACV synthetase from Cephalosporium acremonium and Streptomyces clavuligerus. Evidence for the presence of phosphopantothenate in ACV synthetase. J Antibiot (Tokyo). 1991 Feb; 44(2):241-8. PMID: 2010361.
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    408. Schofield CJ. Vector population responses to control interventions. Ann Soc Belg Med Trop. 1991; 71 Suppl 1:201-17. PMID: 1793271.
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    409. Aplin RT, Baldwin JE, Schofield CJ, Waley SG. Use of electrospray mass spectrometry to directly observe an acyl enzyme intermediate in beta-lactamase catalysis. FEBS Lett. 1990 Dec 17; 277(1-2):212-4. PMID: 2269358.
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    410. Baldwin JE, Bird JW, Field RA, O'Callaghan NM, Schofield CJ. Isolation and partial characterisation of ACV synthetase from Cephalosporium acremonium and Streptomyces clavuligerus. J Antibiot (Tokyo). 1990 Aug; 43(8):1055-7. PMID: 2211358.
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    411. Aplin RT, Baldwin JE, Fujishima Y, Schofield CJ, Green BN, Jarvis SA. Molecular weight analysis of isopenicillin N synthase by electrospray mass spectrometry. FEBS Lett. 1990 May 21; 264(2):215-7. PMID: 2192915.
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    412. Hayes RJ, Schofield CJ. [Estimate of the incidence rates of chronic parasitosis and infections based on the prevalence: Chagas disease in Latin America]. Bol Oficina Sanit Panam. 1990 Apr; 108(4):308-16. PMID: 2143904.
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    413. Whiteman PA, Abraham EP, Baldwin JE, Fleming MD, Schofield CJ, Sutherland JD, Willis AC. Acyl coenzyme A: 6-aminopenicillanic acid acyltransferase from Penicillium chrysogenum and Aspergillus nidulans. FEBS Lett. 1990 Mar 26; 262(2):342-4. PMID: 2110531.
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    414. Baldwin JE, Blackburn JM, Schofield CJ, Sutherland JD. High level expression in Escherichia coli of a fungal gene under the control of strong promoters. FEMS Microbiol Lett. 1990 Mar 01; 56(1-2):45-51. PMID: 2185127.
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    415. Schofield C, Stewart J, Wheeler E. The diets of pregnant and post-pregnant women in different social groups in London and Edinburgh: calcium, iron, retinol, ascorbic acid and folic acid. Br J Nutr. 1989 Sep; 62(2):363-77. PMID: 2819020.
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    416. Gorla DE, Schofield CJ. Population dynamics of Triatoma infestans under natural climatic conditions in the Argentine Chaco. Med Vet Entomol. 1989 Apr; 3(2):179-94. PMID: 2519662.
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    417. Baldwin JE, Adlington RM, Crouch NP, Coates JB, Keeping JW, Schofield CJ, Shuttleworth WA, Sutherland JD. Substrate specificity of cloned deacetoxycephalosporin C/deacetylcephalosporin C synthetase. J Antibiot (Tokyo). 1988 Nov; 41(11):1694-5. PMID: 3198501.
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    418. Schofield C, Wheeler E, Stewart J. The diets of pregnant and post-pregnant women in different social groups in London and Edinburgh: energy, protein, fat and fibre. Br J Nutr. 1987 Nov; 58(3):369-81. PMID: 2825764.
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    419. Baldwin JE, Adlington RM, Coates JB, Crabbe MJ, Crouch NP, Keeping JW, Knight GC, Schofield CJ, Ting HH, Vallejo CA, et al. Purification and initial characterization of an enzyme with deacetoxycephalosporin C synthetase and hydroxylase activities. Biochem J. 1987 Aug 01; 245(3):831-41. PMID: 3663194; PMCID: PMC1148204.
    420. Kirk ML, Schofield CJ. Density-dependent timing of defaecation by Rhodnius prolixus, and its implications for the transmission of Trypanosoma cruzi. Trans R Soc Trop Med Hyg. 1987; 81(2):348-9. PMID: 3113007.
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    421. Schofield CJ, Williams NG, Kirk ML, Garcia Zapata MT, Marsden PD. A key for identifying faecal smears to detect domestic infestations of triatomine bugs. Rev Soc Bras Med Trop. 1986 Jan-Mar; 19(1):5-8. PMID: 3317559.
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    422. Schofield CJ, Matthews JN. Theoretical approach to active dispersal and colonization of houses by Triatoma infestans. J Trop Med Hyg. 1985 Jun; 88(3):211-22. PMID: 3906147.
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    423. Schofield CJ. Control of Chagas' disease vectors. Br Med Bull. 1985 Apr; 41(2):187-94. PMID: 3928022.
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    424. Schofield CJ. Population dynamics and control of Triatoma infestans. Ann Soc Belg Med Trop. 1985; 65 Suppl 1:149-64. PMID: 3931580.
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    425. Garcia Zapata MT, Schofield CJ, Marsden PD. A simple method to detect the presence of live triatomine bugs in houses sprayed with residual insecticides. Trans R Soc Trop Med Hyg. 1985; 79(4):558-9. PMID: 3909557.
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    426. Miles MA, Apt B W, Widmer G, Povoa MM, Schofield CJ. Isozyme heterogeneity and numerical taxonomy of Trypanosoma cruzi stocks from Chile. Trans R Soc Trop Med Hyg. 1984; 78(4):526-35. PMID: 6237475.
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    427. Schofield CJ, White GB. House design and domestic vectors of disease. Trans R Soc Trop Med Hyg. 1984; 78(3):285-92. PMID: 6547790.
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    428. Schofield CJ, Apt W, Miles MA. The ecology of Chagas disease in Chile. Ecol Dis. 1982; 1(2-3):117-29. PMID: 6821391.
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    429. Schofield CJ, Marsden PD. The effect of wall plaster on a domestic population of Triatoma infestans. Bull Pan Am Health Organ. 1982; 16(4):356-60. PMID: 6819871.
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    430. Schofield CJ. Chagas disease, triatomine bugs, and bloodloss. Lancet. 1981 Jun 13; 1(8233):1316. PMID: 6112630.
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    431. Lehane MJ, Schofield CJ. Field experiments of dispersive flight by Triatoma infestans. Trans R Soc Trop Med Hyg. 1981; 75(3):399-400. PMID: 7034312.
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    432. Schofield CJ. Nutritional status of domestic populations of Triatoma infestans. Trans R Soc Trop Med Hyg. 1980; 74(6):770-8. PMID: 7010698.
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    433. Schofield CJ. Density regulation of domestic populations of Triatoma infestans in Brazil. Trans R Soc Trop Med Hyg. 1980; 74(6):761-9. PMID: 7010697.
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    434. Schofield CJ. Demonstration of isobutyric acid in some triatomine bugs. Acta Trop. 1979 Mar; 36(1):103-5. PMID: 35929.
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    435. Schofield CJ. A comparison of sampling techniques for domestic populations of Triatominae. Trans R Soc Trop Med Hyg. 1978; 72(5):449-55. PMID: 364782.
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    436. Schofield CJ, Patterson JW. Assembly pheromone of Triatoma infestans and Rhodnius prolixus nymphs (Hemiptera: Reduviidae). J Med Entomol. 1977 Jun 20; 13(6):727-34. PMID: 328883.
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    437. Schofield CJ, Moreman K. Letter: Apparent absence of a sex attractant in adult Triatoma infestans (Klug), vector of Chagas' disease. Trans R Soc Trop Med Hyg. 1976; 70(2):165-6. PMID: 822541.
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    438. Lehane MJ, Schofield CJ. Preliminary report on flight by some triatomine bugs. Trans R Soc Trop Med Hyg. 1976; 70(5-6):526. PMID: 320728.
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