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Professor Rick Lee Tarleton

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Soares Medeiros LC, South L, Peng D, Bustamante JM, Wang W, Bunkofske M, Perumal N, Sanchez-Valdez F, Tarleton RL. Rapid, Selection-Free, High-Efficiency Genome Editing in Protozoan Parasites Using CRISPR-Cas9 Ribonucleoproteins. MBio. 2017 Nov 07; 8(6). PMID: 29114029.
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    2. Weatherly DB, Peng D, Tarleton RL. Recombination-driven generation of the largest pathogen repository of antigen variants in the protozoan Trypanosoma cruzi. BMC Genomics. 2016 09 13; 17(1):729. PMID: 27619017; PMCID: PMC5020489.
    3. Rosenberg CS, Zhang W, Bustamante JM, Tarleton RL. Long-Term Immunity to Trypanosoma cruzi in the Absence of Immunodominant trans-Sialidase-Specific CD8+ T Cells. Infect Immun. 2016 09; 84(9):2627-38. PMID: 27354447; PMCID: PMC4995909 [Available on 02/19/17].
    4. Tarleton RL. Chagas Disease: A Solvable Problem, Ignored. Trends Mol Med. 2016 Oct; 22(10):835-838. PMID: 27523778.
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    5. Asiaee AH, Minning T, Doshi P, Tarleton RL. A framework for ontology-based question answering with application to parasite immunology. J Biomed Semantics. 2015; 6:31. PMID: 26185615; PMCID: PMC4504081.
    6. Tarleton RL. CD8+ T cells in Trypanosoma cruzi infection. Semin Immunopathol. 2015 May; 37(3):233-8. PMID: 25921214; PMCID: PMC4654118.
    7. Bustamante J, Tarleton R. Reaching for the Holy Grail: insights from infection/cure models on the prospects for vaccines for Trypanosoma cruzi infection. Mem Inst Oswaldo Cruz. 2015 May; 110(3):445-51. PMID: 25946159; PMCID: PMC4489482.
    8. Albareda MC, Perez-Mazliah D, Natale MA, Castro-Eiro M, Alvarez MG, Viotti R, Bertocchi G, Lococo B, Tarleton RL, Laucella SA. Perturbed T cell IL-7 receptor signaling in chronic Chagas disease. J Immunol. 2015 Apr 15; 194(8):3883-9. PMID: 25769928; PMCID: PMC4391971.
    9. Hartley AN, Tarleton RL. Chemokine receptor 7 (CCR7)-expression and IFN? production define vaccine-specific canine T-cell subsets. Vet Immunol Immunopathol. 2015 Apr 15; 164(3-4):127-36. PMID: 25758065; PMCID: PMC4387071.
    10. Peng D, Kurup SP, Yao PY, Minning TA, Tarleton RL. CRISPR-Cas9-mediated single-gene and gene family disruption in Trypanosoma cruzi. MBio. 2014 Dec 30; 6(1):e02097-14. PMID: 25550322; PMCID: PMC4281920.
    11. Tarleton RL, Gürtler RE, Urbina JA, Ramsey J, Viotti R. Chagas disease and the london declaration on neglected tropical diseases. PLoS Negl Trop Dis. 2014 Oct; 8(10):e3219. PMID: 25299701; PMCID: PMC4191937.
    12. Kurup SP, Tarleton RL. The Trypanosoma cruzi flagellum is discarded via asymmetric cell division following invasion and provides early targets for protective CD8? T cells. Cell Host Microbe. 2014 Oct 08; 16(4):439-49. PMID: 25299330; PMCID: PMC4194031.
    13. Bustamante JM, Tarleton RL. Potential new clinical therapies for Chagas disease. Expert Rev Clin Pharmacol. 2014 May; 7(3):317-25. PMID: 24716790.
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    14. Hartley AN, Cooley G, Gwyn S, Orozco MM, Tarleton RL. Frequency of IFN?-producing T cells correlates with seroreactivity and activated T cells during canine Trypanosoma cruzi infection. Vet Res. 2014 Jan 23; 45:6. PMID: 24456537; PMCID: PMC3907784.
    15. Albareda MC, De Rissio AM, Tomas G, Serjan A, Alvarez MG, Viotti R, Fichera LE, Esteva MI, Potente D, Armenti A, Tarleton RL, Laucella SA. Polyfunctional T cell responses in children in early stages of chronic Trypanosoma cruzi infection contrast with monofunctional responses of long-term infected adults. PLoS Negl Trop Dis. 2013; 7(12):e2575. PMID: 24349591; PMCID: PMC3861186.
    16. Galizzi M, Bustamante JM, Fang J, Miranda K, Soares Medeiros LC, Tarleton RL, Docampo R. Evidence for the role of vacuolar soluble pyrophosphatase and inorganic polyphosphate in Trypanosoma cruzi persistence. Mol Microbiol. 2013 Nov; 90(4):699-715. PMID: 24033456; PMCID: PMC3826824.
    17. Bustamante JM, Craft JM, Crowe BD, Ketchie SA, Tarleton RL. New, combined, and reduced dosing treatment protocols cure Trypanosoma cruzi infection in mice. J Infect Dis. 2014 Jan 01; 209(1):150-62. PMID: 23945371; PMCID: PMC3864384.
    18. Kurup SP, Tarleton RL. Perpetual expression of PAMPs necessary for optimal immune control and clearance of a persistent pathogen. Nat Commun. 2013; 4:2616. PMID: 24149620; PMCID: PMC4161029.
    19. Afonso AM, Ebell MH, Tarleton RL. A systematic review of high quality diagnostic tests for Chagas disease. PLoS Negl Trop Dis. 2012; 6(11):e1881. PMID: 23145201; PMCID: PMC3493394.
    20. Perez-Mazliah DE, Alvarez MG, Cooley G, Lococo BE, Bertocchi G, Petti M, Albareda MC, Armenti AH, Tarleton RL, Laucella SA, Viotti R. Sequential combined treatment with allopurinol and benznidazole in the chronic phase of Trypanosoma cruzi infection: a pilot study. J Antimicrob Chemother. 2013 Feb; 68(2):424-37. PMID: 23104493; PMCID: PMC3543119.
    21. Tarleton RL, Curran JW. Is Chagas disease really the "new HIV/AIDS of the Americas"? PLoS Negl Trop Dis. 2012; 6(10):e1861. PMID: 23145193; PMCID: PMC3493379.
    22. Argüello RJ, Albareda MC, Alvarez MG, Bertocchi G, Armenti AH, Vigliano C, Meckert PC, Tarleton RL, Laucella SA. Inhibitory receptors are expressed by Trypanosoma cruzi-specific effector T cells and in hearts of subjects with chronic Chagas disease. PLoS One. 2012; 7(5):e35966. PMID: 22574131; PMCID: PMC3344843.
    23. Rodriguez A, Tarleton RL. Transgenic parasites accelerate drug discovery. Trends Parasitol. 2012 Mar; 28(3):90-2. PMID: 22277131; PMCID: PMC3673567.
    24. Parikh PP, Minning TA, Nguyen V, Lalithsena S, Asiaee AH, Sahoo SS, Doshi P, Tarleton R, Sheth AP. A semantic problem solving environment for integrative parasite research: identification of intervention targets for Trypanosoma cruzi. PLoS Negl Trop Dis. 2012 Jan; 6(1):e1458. PMID: 22272365; PMCID: PMC3260319.
    25. Perez Brandan C, Padilla AM, Xu D, Tarleton RL, Basombrio MA. Knockout of the dhfr-ts gene in Trypanosoma cruzi generates attenuated parasites able to confer protection against a virulent challenge. PLoS Negl Trop Dis. 2011 Dec; 5(12):e1418. PMID: 22180798; PMCID: PMC3236718.
    26. Viotti R, Vigliano C, Alvarez MG, Lococo B, Petti M, Bertocchi G, Armenti A, De Rissio AM, Cooley G, Tarleton R, Laucella S. Impact of aetiological treatment on conventional and multiplex serology in chronic Chagas disease. PLoS Negl Trop Dis. 2011 Sep; 5(9):e1314. PMID: 21909451; PMCID: PMC3167788.
    27. Bustamante JM, Park HJ, Tarleton RL. Report of the 2nd Chagas Drug Discovery Consortium meeting, held on 3 November 2010; Atlanta GA, USA. Expert Opin Drug Discov. 2011 09; 6(9):965-73. PMID: 22646217.
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    28. Collins MH, Craft JM, Bustamante JM, Tarleton RL. Oral exposure to Trypanosoma cruzi elicits a systemic CD8? T cell response and protection against heterotopic challenge. Infect Immun. 2011 Aug; 79(8):3397-406. PMID: 21628516; PMCID: PMC3147593.
    29. Ulrich PN, Jimenez V, Park M, Martins VP, Atwood J, Moles K, Collins D, Rohloff P, Tarleton R, Moreno SN, Orlando R, Docampo R. Identification of contractile vacuole proteins in Trypanosoma cruzi. PLoS One. 2011 Mar 18; 6(3):e18013. PMID: 21437209; PMCID: PMC3060929.
    30. Minning TA, Weatherly DB, Flibotte S, Tarleton RL. Widespread, focal copy number variations (CNV) and whole chromosome aneuploidies in Trypanosoma cruzi strains revealed by array comparative genomic hybridization. BMC Genomics. 2011 Mar 07; 12:139. PMID: 21385342; PMCID: PMC3060142.
    31. Ekanayake DK, Minning T, Weatherly B, Gunasekera K, Nilsson D, Tarleton R, Ochsenreiter T, Sabatini R. Epigenetic regulation of transcription and virulence in Trypanosoma cruzi by O-linked thymine glucosylation of DNA. Mol Cell Biol. 2011 Apr; 31(8):1690-700. PMID: 21321080; PMCID: PMC3126337.
    32. Canavaci AM, Bustamante JM, Padilla AM, Perez Brandan CM, Simpson LJ, Xu D, Boehlke CL, Tarleton RL. In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds. PLoS Negl Trop Dis. 2010 Jul 13; 4(7):e740. PMID: 20644616; PMCID: PMC2903469.
    33. Rosenberg CS, Martin DL, Tarleton RL. CD8+ T cells specific for immunodominant trans-sialidase epitopes contribute to control of Trypanosoma cruzi infection but are not required for resistance. J Immunol. 2010 Jul 01; 185(1):560-8. PMID: 20530265; PMCID: PMC3784248.
    34. Martin DL, Murali-Krishna K, Tarleton RL. Generation of Trypanosoma cruzi-specific CD8+ T-cell immunity is unaffected by the absence of type I interferon signaling. Infect Immun. 2010 Jul; 78(7):3154-9. PMID: 20457790; PMCID: PMC2897408.
    35. Aponte JC, Vaisberg AJ, Castillo D, Gonzalez G, Estevez Y, Arevalo J, Quiliano M, Zimic M, Verástegui M, Málaga E, Gilman RH, Bustamante JM, Tarleton RL, Wang Y, Franzblau SG, Pauli GF, Sauvain M, Hammond GB. Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines. Bioorg Med Chem. 2010 Apr 15; 18(8):2880-6. PMID: 20356752.
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    36. Olivera GC, Albareda MC, Alvarez MG, De Rissio AM, Fichera LE, Cooley G, Yachelini P, Hrellac HA, Riboldi H, Laucella SA, Tarleton RL, Postan M. Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina. Microbes Infect. 2010 May; 12(5):359-63. PMID: 20123034; PMCID: PMC2856734.
    37. Laucella SA, Mazliah DP, Bertocchi G, Alvarez MG, Cooley G, Viotti R, Albareda MC, Lococo B, Postan M, Armenti A, Tarleton RL. Changes in Trypanosoma cruzi-specific immune responses after treatment: surrogate markers of treatment efficacy. Clin Infect Dis. 2009 Dec 01; 49(11):1675-84. PMID: 19877967; PMCID: PMC2805187.
    38. Albareda MC, Olivera GC, Laucella SA, Alvarez MG, Fernandez ER, Lococo B, Viotti R, Tarleton RL, Postan M. Chronic human infection with Trypanosoma cruzi drives CD4+ T cells to immune senescence. J Immunol. 2009 Sep 15; 183(6):4103-8. PMID: 19692645; PMCID: PMC3074976.
    39. Minning TA, Weatherly DB, Atwood J, Orlando R, Tarleton RL. The steady-state transcriptome of the four major life-cycle stages of Trypanosoma cruzi. BMC Genomics. 2009 Aug 07; 10:370. PMID: 19664227; PMCID: PMC2907688.
    40. Padilla AM, Bustamante JM, Tarleton RL. CD8+ T cells in Trypanosoma cruzi infection. Curr Opin Immunol. 2009 Aug; 21(4):385-90. PMID: 19646853; PMCID: PMC2735075.
    41. Padilla AM, Simpson LJ, Tarleton RL. Insufficient TLR activation contributes to the slow development of CD8+ T cell responses in Trypanosoma cruzi infection. J Immunol. 2009 Jul 15; 183(2):1245-52. PMID: 19553540.
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    42. Weatherly DB, Boehlke C, Tarleton RL. Chromosome level assembly of the hybrid Trypanosoma cruzi genome. BMC Genomics. 2009 Jun 01; 10:255. PMID: 19486522; PMCID: PMC2698008.
    43. Xu D, Brandán CP, Basombrío MA, Tarleton RL. Evaluation of high efficiency gene knockout strategies for Trypanosoma cruzi. BMC Microbiol. 2009 May 11; 9:90. PMID: 19432966; PMCID: PMC2688506.
    44. Reithinger R, Tarleton RL, Urbina JA, Kitron U, Gürtler RE. Eliminating Chagas disease: challenges and a roadmap. BMJ. 2009 Apr 14; 338:b1283. PMID: 19366739; PMCID: PMC3085889.
    45. Ayub MJ, Atwood J, Nuccio A, Tarleton R, Levin MJ. Proteomic analysis of the Trypanosoma cruzi ribosomal proteins. Biochem Biophys Res Commun. 2009 Apr 24; 382(1):30-4. PMID: 19245787.
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    46. Cooley G, Etheridge RD, Boehlke C, Bundy B, Weatherly DB, Minning T, Haney M, Postan M, Laucella S, Tarleton RL. High throughput selection of effective serodiagnostics for Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2008 Oct 08; 2(10):e316. PMID: 18841200; PMCID: PMC2556098.
    47. Alvarez MG, Postan M, Weatherly DB, Albareda MC, Sidney J, Sette A, Olivera C, Armenti AH, Tarleton RL, Laucella SA. HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease. PLoS Negl Trop Dis. 2008; 2(9):e288. PMID: 18846233; PMCID: PMC2565697.
    48. Bixby LM, Tarleton RL. Stable CD8+ T cell memory during persistent Trypanosoma cruzi infection. J Immunol. 2008 Aug 15; 181(4):2644-50. PMID: 18684955; PMCID: PMC2735072.
    49. Bustamante JM, Bixby LM, Tarleton RL. Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease. Nat Med. 2008 May; 14(5):542-50. PMID: 18425131; PMCID: PMC3074975.
    50. Stuart K, Brun R, Croft S, Fairlamb A, Gürtler RE, McKerrow J, Reed S, Tarleton R. Kinetoplastids: related protozoan pathogens, different diseases. J Clin Invest. 2008 Apr; 118(4):1301-10. PMID: 18382742; PMCID: PMC2276762.
    51. Tarleton RL, Reithinger R, Urbina JA, Kitron U, Gürtler RE. The challenges of Chagas Disease-- grim outlook or glimmer of hope. PLoS Med. 2007 Dec; 4(12):e332. PMID: 18162039; PMCID: PMC2222930.
    52. Martin DL, Postan M, Lucas P, Gress R, Tarleton RL. TGF-beta regulates pathology but not tissue CD8+ T cell dysfunction during experimental Trypanosoma cruzi infection. Eur J Immunol. 2007 Oct; 37(10):2764-71. PMID: 17823982.
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    53. Tarleton RL. Immune system recognition of Trypanosoma cruzi. Curr Opin Immunol. 2007 Aug; 19(4):430-4. PMID: 17651955.
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    54. Graham RL, Sharma MK, Ternan NG, Weatherly DB, Tarleton RL, McMullan G. A semi-quantitative GeLC-MS analysis of temporal proteome expression in the emerging nosocomial pathogen Ochrobactrum anthropi. Genome Biol. 2007; 8(6):R110. PMID: 17567905; PMCID: PMC2394761.
    55. Graham RL, Pollock CE, O'Loughlin SN, Ternan NG, Weatherly DB, Tarleton RL, McMullan G. Multidimensional analysis of the insoluble sub-proteome of Oceanobacillus iheyensis HTE831, an alkaliphilic and halotolerant deep-sea bacterium isolated from the Iheya ridge. Proteomics. 2007 Jan; 7(1):82-91. PMID: 17146838.
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    56. Atwood JA, Minning T, Ludolf F, Nuccio A, Weatherly DB, Alvarez-Manilla G, Tarleton R, Orlando R. Glycoproteomics of Trypanosoma cruzi trypomastigotes using subcellular fractionation, lectin affinity, and stable isotope labeling. J Proteome Res. 2006 Dec; 5(12):3376-84. PMID: 17137339.
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    57. Kotner J, Tarleton R. Endogenous CD4(+) CD25(+) regulatory T cells have a limited role in the control of Trypanosoma cruzi infection in mice. Infect Immun. 2007 Feb; 75(2):861-9. PMID: 17101658; PMCID: PMC1828478.
    58. Graham RL, Pollock CE, O'Loughlin SN, Ternan NG, Weatherly DB, Jackson PJ, Tarleton RL, McMullan G. Multidimensional proteomic analysis of the soluble subproteome of the emerging nosocomial pathogen Ochrobactrum anthropi. J Proteome Res. 2006 Nov; 5(11):3145-53. PMID: 17081066.
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    59. Padilla A, Xu D, Martin D, Tarleton R. Limited role for CD4+ T-cell help in the initial priming of Trypanosoma cruzi-specific CD8+ T cells. Infect Immun. 2007 Jan; 75(1):231-5. PMID: 17043105; PMCID: PMC1828400.
    60. Graham RL, O'Loughlin SN, Pollock CE, Ternan NG, Weatherly DB, Jackson PJ, Tarleton RL, McMullan G. A combined shotgun and multidimensional proteomic analysis of the insoluble subproteome of the obligate thermophile, Geobacillus thermoleovorans T80. J Proteome Res. 2006 Sep; 5(9):2465-73. PMID: 16944960.
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    61. Martin DL, Weatherly DB, Laucella SA, Cabinian MA, Crim MT, Sullivan S, Heiges M, Craven SH, Rosenberg CS, Collins MH, Sette A, Postan M, Tarleton RL. CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes. PLoS Pathog. 2006 Aug; 2(8):e77. PMID: 16879036; PMCID: PMC1526708.
    62. Potenza M, Galat A, Minning TA, Ruiz AM, Duran R, Tarleton RL, Marín M, Fichera LE, Búa J. Analysis of the Trypanosoma cruzi cyclophilin gene family and identification of Cyclosporin A binding proteins. Parasitology. 2006 Jun; 132(Pt 6):867-82. PMID: 16700961.
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    63. Albareda MC, Laucella SA, Alvarez MG, Armenti AH, Bertochi G, Tarleton RL, Postan M. Trypanosoma cruzi modulates the profile of memory CD8+ T cells in chronic Chagas' disease patients. Int Immunol. 2006 Mar; 18(3):465-71. PMID: 16431876.
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    64. Tarleton RL. New approaches in vaccine development for parasitic infections. Cell Microbiol. 2005 Oct; 7(10):1379-86. PMID: 16153238.
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    65. Atwood JA, Weatherly DB, Minning TA, Bundy B, Cavola C, Opperdoes FR, Orlando R, Tarleton RL. The Trypanosoma cruzi proteome. Science. 2005 Jul 15; 309(5733):473-6. PMID: 16020736.
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    66. El-Sayed NM, Myler PJ, Bartholomeu DC, Nilsson D, Aggarwal G, Tran AN, Ghedin E, Worthey EA, Delcher AL, Blandin G, Westenberger SJ, Caler E, Cerqueira GC, Branche C, Haas B, Anupama A, Arner E, Aslund L, Attipoe P, Bontempi E, Bringaud F, Burton P, Cadag E, Campbell DA, Carrington M, Crabtree J, Darban H, da Silveira JF, de Jong P, Edwards K, Englund PT, Fazelina G, Feldblyum T, Ferella M, Frasch AC, Gull K, Horn D, Hou L, Huang Y, Kindlund E, Klingbeil M, Kluge S, Koo H, Lacerda D, Levin MJ, Lorenzi H, Louie T, Machado CR, McCulloch R, McKenna A, Mizuno Y, Mottram JC, Nelson S, Ochaya S, Osoegawa K, Pai G, Parsons M, Pentony M, Pettersson U, Pop M, Ramirez JL, Rinta J, Robertson L, Salzberg SL, Sanchez DO, Seyler A, Sharma R, Shetty J, Simpson AJ, Sisk E, Tammi MT, Tarleton R, Teixeira S, Van Aken S, Vogt C, Ward PN, Wickstead B, Wortman J, White O, Fraser CM, Stuart KD, Andersson B. The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science. 2005 Jul 15; 309(5733):409-15. PMID: 16020725.
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    67. Weatherly DB, Atwood JA, Minning TA, Cavola C, Tarleton RL, Orlando R. A Heuristic method for assigning a false-discovery rate for protein identifications from Mascot database search results. Mol Cell Proteomics. 2005 Jun; 4(6):762-72. PMID: 15703444.
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    68. Martin DL, Tarleton RL. Antigen-specific T cells maintain an effector memory phenotype during persistent Trypanosoma cruzi infection. J Immunol. 2005 Feb 01; 174(3):1594-601. PMID: 15661921.
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    69. Martin D, Tarleton R. Generation, specificity, and function of CD8+ T cells in Trypanosoma cruzi infection. Immunol Rev. 2004 Oct; 201:304-17. PMID: 15361249.
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    70. Cummings KL, Tarleton RL. Inducible nitric oxide synthase is not essential for control of Trypanosoma cruzi infection in mice. Infect Immun. 2004 Jul; 72(7):4081-9. PMID: 15213153; PMCID: PMC427393.
    71. Laucella SA, Postan M, Martin D, Hubby Fralish B, Albareda MC, Alvarez MG, Lococo B, Barbieri G, Viotti RJ, Tarleton RL. Frequency of interferon- gamma -producing T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas disease. J Infect Dis. 2004 Mar 01; 189(5):909-18. PMID: 14976609.
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    72. Luchtan M, Warade C, Weatherly DB, Degrave WM, Tarleton RL, Kissinger JC. TcruziDB: an integrated Trypanosoma cruzi genome resource. Nucleic Acids Res. 2004 Jan 01; 32(Database issue):D344-6. PMID: 14681430; PMCID: PMC308783.
    73. Tarleton RL. Chagas disease: a role for autoimmunity? Trends Parasitol. 2003 Oct; 19(10):447-51. PMID: 14519582.
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    74. Minning TA, Bua J, Garcia GA, McGraw RA, Tarleton RL. Microarray profiling of gene expression during trypomastigote to amastigote transition in Trypanosoma cruzi. Mol Biochem Parasitol. 2003 Sep; 131(1):55-64. PMID: 12967712.
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    75. Fralish BH, Tarleton RL. Genetic immunization with LYT1 or a pool of trans-sialidase genes protects mice from lethal Trypanosoma cruzi infection. Vaccine. 2003 Jun 20; 21(21-22):3070-80. PMID: 12798651.
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    76. Cummings KL, Tarleton RL. Rapid quantitation of Trypanosoma cruzi in host tissue by real-time PCR. Mol Biochem Parasitol. 2003 Jun; 129(1):53-9. PMID: 12798506.
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    77. Leavey JK, Tarleton RL. Cutting edge: dysfunctional CD8+ T cells reside in nonlymphoid tissues during chronic Trypanosoma cruzi infection. J Immunol. 2003 Mar 01; 170(5):2264-8. PMID: 12594245.
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    78. Garg N, Tarleton RL. Genetic immunization elicits antigen-specific protective immune responses and decreases disease severity in Trypanosoma cruzi infection. Infect Immun. 2002 Oct; 70(10):5547-55. PMID: 12228281; PMCID: PMC128309.
    79. Tarleton RL, Kissinger J. Parasite genomics: current status and future prospects. Curr Opin Immunol. 2001 Aug; 13(4):395-402. PMID: 11498294.
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    80. Tarleton RL. Parasite persistence in the aetiology of Chagas disease. Int J Parasitol. 2001 May 01; 31(5-6):550-4. PMID: 11334941.
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    81. Kumar S, Tarleton RL. Antigen-specific Th1 but not Th2 cells provide protection from lethal Trypanosoma cruzi infection in mice. J Immunol. 2001 Apr 01; 166(7):4596-603. PMID: 11254717.
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    82. Tarleton RL, Grusby MJ, Zhang L. Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. J Immunol. 2000 Aug 01; 165(3):1520-5. PMID: 10903759.
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    83. Zhang L, Tarleton RL. Parasite persistence correlates with disease severity and localization in chronic Chagas' disease. J Infect Dis. 1999 Aug; 180(2):480-6. PMID: 10395865.
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    84. Tarleton RL, Zhang L. Chagas disease etiology: autoimmunity or parasite persistence? Parasitol Today. 1999 Mar; 15(3):94-9. PMID: 10322321.
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    85. Brockman AH, Orlando R, Tarleton RL. A new liquid chromatography/tandem mass spectrometric approach for the identification of class I major histocompatibility complex associated peptides that eliminates the need for bioassays. Rapid Commun Mass Spectrom. 1999; 13(11):1024-30. PMID: 10368978.
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    86. Wizel B, Garg N, Tarleton RL. Vaccination with trypomastigote surface antigen 1-encoding plasmid DNA confers protection against lethal Trypanosoma cruzi infection. Infect Immun. 1998 Nov; 66(11):5073-81. PMID: 9784506; PMCID: PMC108632.
    87. Wizel B, Palmieri M, Mendoza C, Arana B, Sidney J, Sette A, Tarleton R. Human infection with Trypanosoma cruzi induces parasite antigen-specific cytotoxic T lymphocyte responses. J Clin Invest. 1998 Sep 01; 102(5):1062-71. PMID: 9727076; PMCID: PMC508973.
    88. Kumar S, Tarleton RL. The relative contribution of antibody production and CD8+ T cell function to immune control of Trypanosoma cruzi. Parasite Immunol. 1998 May; 20(5):207-16. PMID: 9651921.
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    89. Low HP, Santos MA, Wizel B, Tarleton RL. Amastigote surface proteins of Trypanosoma cruzi are targets for CD8+ CTL. J Immunol. 1998 Feb 15; 160(4):1817-23. PMID: 9469442.
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    90. Wizel B, Nunes M, Tarleton RL. Identification of Trypanosoma cruzi trans-sialidase family members as targets of protective CD8+ TC1 responses. J Immunol. 1997 Dec 15; 159(12):6120-30. PMID: 9550413.
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    91. Garg N, Postan M, Mensa-Wilmot K, Tarleton RL. Glycosylphosphatidylinositols are required for the development of Trypanosoma cruzi amastigotes. Infect Immun. 1997 Oct; 65(10):4055-60. PMID: 9317007; PMCID: PMC175583.
    92. Low HP, Tarleton RL. Molecular cloning of the gene encoding the 83 kDa amastigote surface protein and its identification as a member of the Trypanosoma cruzi sialidase superfamily. Mol Biochem Parasitol. 1997 Sep; 88(1-2):137-49. PMID: 9274875.
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    93. Garg N, Tarleton RL, Mensa-Wilmot K. Proteins with glycosylphosphatidylinositol (GPI) signal sequences have divergent fates during a GPI deficiency. GPIs are essential for nuclear division in Trypanosoma cruzi. J Biol Chem. 1997 May 09; 272(19):12482-91. PMID: 9139697.
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    94. Santos MA, Garg N, Tarleton RL. The identification and molecular characterization of Trypanosoma cruzi amastigote surface protein-1, a member of the trans-sialidase gene super-family. Mol Biochem Parasitol. 1997 May; 86(1):1-11. PMID: 9178263.
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    95. Tarleton RL, Zhang L, Downs MO. "Autoimmune rejection" of neonatal heart transplants in experimental Chagas disease is a parasite-specific response to infected host tissue. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):3932-7. PMID: 9108082; PMCID: PMC20545.
    96. Garg N, Nunes MP, Tarleton RL. Delivery by Trypanosoma cruzi of proteins into the MHC class I antigen processing and presentation pathway. J Immunol. 1997 Apr 01; 158(7):3293-302. PMID: 9120286.
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    97. Zhang L, Tarleton RL. Persistent production of inflammatory and anti-inflammatory cytokines and associated MHC and adhesion molecule expression at the site of infection and disease in experimental Trypanosoma cruzi infections. Exp Parasitol. 1996 Nov; 84(2):203-13. PMID: 8932770.
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    98. Tarleton RL, Grusby MJ, Postan M, Glimcher LH. Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease. Int Immunol. 1996 Jan; 8(1):13-22. PMID: 8671585.
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    99. Zhang L, Tarleton RL. Characterization of cytokine production in murine Trypanosoma cruzi infection by in situ immunocytochemistry: lack of association between susceptibility and type 2 cytokine production. Eur J Immunol. 1996 Jan; 26(1):102-9. PMID: 8566051.
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    100. Benavides GR, Hubby B, Grosse WM, McGraw RA, Tarleton RL. Construction and use of a multi-competitor gene for quantitative RT-PCR using existing primer sets. J Immunol Methods. 1995 Apr 26; 181(2):145-56. PMID: 7745244.
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    101. Tarleton RL. The role of T cells in Trypanosoma cruzi infections. Parasitol Today. 1995 Jan; 11(1):7-9. PMID: 15275408.
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    102. Postan M, Correa R, Ferrans VJ, Tarleton RL. In vitro culture of cardiac mast cells from mice experimentally infected with Trypanosoma cruzi. Int Arch Allergy Immunol. 1994 Nov; 105(3):251-7. PMID: 7920027.
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    103. Tarleton RL, Sun J, Zhang L, Postan M. Depletion of T-cell subpopulations results in exacerbation of myocarditis and parasitism in experimental Chagas' disease. Infect Immun. 1994 May; 62(5):1820-9. PMID: 8168945; PMCID: PMC186416.
    104. Granath WO, Connors VA, Tarleton RL. Interleukin 1 activity in haemolymph from strains of the snail Biomphalaria glabrata varying in susceptibility to the human blood fluke, Schistosoma mansoni: presence, differential expression, and biological function. Cytokine. 1994 Jan; 6(1):21-7. PMID: 8003629.
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    105. Soong L, Tarleton RL. Trypanosoma cruzi infection suppresses nuclear factors that bind to specific sites on the interleukin-2 enhancer. Eur J Immunol. 1994 Jan; 24(1):16-23. PMID: 8020551.
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    106. Sullivan JJ, Steurer F, Benavides G, Tarleton RL, Eberhard ML, Landry S. Trypanosomes and microfilariae in feral owl and squirrel monkeys maintained in research colonies. Am J Trop Med Hyg. 1993 Aug; 49(2):254-9. PMID: 8357088.
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    107. Benavides GR, Sullivan JJ, Steurer F, McGraw RA, Tarleton RL. Differentiation of trypanosomatid species by hybridization to selected rRNA probes. Mol Cell Probes. 1993 Apr; 7(2):89-96. PMID: 8321256.
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    108. Sun J, Tarleton RL. Predominance of CD8+ T lymphocytes in the inflammatory lesions of mice with acute Trypanosoma cruzi infection. Am J Trop Med Hyg. 1993 Feb; 48(2):161-9. PMID: 8447518.
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    109. Soong L, Tarleton RL. Selective suppressive effects of Trypanosoma cruzi infection on IL-2, c-myc, and c-fos gene expression. J Immunol. 1992 Sep 15; 149(6):2095-102. PMID: 1517573.
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    110. Tarleton RL, Koller BH, Latour A, Postan M. Susceptibility of beta 2-microglobulin-deficient mice to Trypanosoma cruzi infection. Nature. 1992 Mar 26; 356(6367):338-40. PMID: 1549177.
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    111. Tarleton RL, Beyer AM. Medium-scale production and purification of monoclonal antibodies in protein-free medium. Biotechniques. 1991 Nov; 11(5):590-3. PMID: 1804247.
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    112. Tarleton RL. Regulation of immunity in Trypanosoma cruzi infection. Exp Parasitol. 1991 Jul; 73(1):106-9. PMID: 1905240.
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    113. Tarleton R. Timely maintenance improves a roof's longevity. Health Facil Manage. 1991 Jun; 4(6):36-8. PMID: 10110679.
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    114. Nabors GS, Tarleton RL. Differential control of IFN-gamma and IL-2 production during Trypanosoma cruzi infection. J Immunol. 1991 May 15; 146(10):3591-8. PMID: 1902857.
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    115. Golden JM, Tarleton RL. Trypanosoma cruzi: cytokine effects on macrophage trypanocidal activity. Exp Parasitol. 1991 May; 72(4):391-402. PMID: 1902795.
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    116. Tarleton RL. The role of T-cell subpopulations in experimental Chagas' disease. Res Immunol. 1991 Feb; 142(2):130-3. PMID: 1678199.
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    117. Morris DD, Moore JN, Fischer K, Tarleton RL. Endotoxin-induced tumor necrosis factor activity production by equine peritoneal macrophages. Circ Shock. 1990 Mar; 30(3):229-36. PMID: 2178798.
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    118. Tarleton RL. Depletion of CD8+ T cells increases susceptibility and reverses vaccine-induced immunity in mice infected with Trypanosoma cruzi. J Immunol. 1990 Jan 15; 144(2):717-24. PMID: 2104903.
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    119. Lappin MR, Greene CE, Prestwood AK, Dawe DL, Tarleton RL. Enzyme-linked immunosorbent assay for the detection of circulating antigens of Toxoplasma gondii in the serum of cats. Am J Vet Res. 1989 Sep; 50(9):1586-90. PMID: 2802337.
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    120. Lappin MR, Greene CE, Prestwood AK, Dawe DL, Tarleton RL. Diagnosis of recent Toxoplasma gondii infection in cats by use of an enzyme-linked immunosorbent assay for immunoglobulin M. Am J Vet Res. 1989 Sep; 50(9):1580-5. PMID: 2802336.
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    121. Tarleton RL. Regulation of lymphokine production in experimental and human Chagas' disease. Mem Inst Oswaldo Cruz. 1988 Nov; 83 Suppl 1:268-71. PMID: 3150991.
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    122. Tarleton RL. Tumour necrosis factor (cachectin) production during experimental Chagas' disease. Clin Exp Immunol. 1988 Aug; 73(2):186-90. PMID: 3141092; PMCID: PMC1541603.
    123. Tarleton RL. Trypanosoma cruzi-induced suppression of IL-2 production. II. Evidence for a role for suppressor cells. J Immunol. 1988 Apr 15; 140(8):2769-73. PMID: 2965730.
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    124. Tarleton RL. Trypanosoma cruzi-induced suppression of IL-2 production. I. Evidence for the presence of IL-2-producing cells. J Immunol. 1988 Apr 15; 140(8):2763-8. PMID: 2965729.
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    125. Tarleton RL, de Andrade PP, de Andrade CR. Interleukin 2 production in patients with Chagas' disease: correlation with anti-parasite antibody responses. Immunol Lett. 1988 Mar; 17(3):229-34. PMID: 3131236.
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    126. Paulin JJ, Keith CH, Tarleton RL. A monoclonal antibody to alpha tubulin recognizes host cell and Trypanosoma cruzi tubulins. J Protozool. 1988 Feb; 35(1):123-9. PMID: 3284998.
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    127. Tarleton RL, Scott DW. Initial induction of immunity, followed by suppression of responses to parasite antigens during Trypanosoma cruzi infection of mice. Parasite Immunol. 1987 Sep; 9(5):579-89. PMID: 2960943.
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    128. Kemp WM, Tarleton RL, McGuinness TB, Rasmussen KR, Devine DV. Biology of tegument associated IgG-Fc and C3 receptors inSchistosoma mansoni. J Chem Ecol. 1986 Aug; 12(8):1833-41. PMID: 24305899.
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    129. Tarleton RL, Kuhn RE. Measurement of parasite-specific immune responses in vitro: evidence for suppression of the antibody response to Trypanosoma cruzi. Eur J Immunol. 1985 Aug; 15(8):845-50. PMID: 3896819.
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    130. Tarleton RL, Kuhn RE. Restoration of in vitro immune responses of spleen cells from mice infected with Trypanosoma cruzi by supernatants containing interleukin 2. J Immunol. 1984 Sep; 133(3):1570-5. PMID: 6431001.
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    131. Tarleton RL, Kuhn RE. Loss of suppressor activity in the serum of mice infected with Trypanosoma cruzi. J Parasitol. 1984 Apr; 70(2):253-60. PMID: 6236293.
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    132. Tarleton RL, Schulz CL, Grögl M, Kuhn RE. Diagnosis of Chagas' disease in humans using a biotin-3H-avidin radioimmunoassay. Am J Trop Med Hyg. 1984 Jan; 33(1):34-40. PMID: 6421182.
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    133. Tarleton RL, Schafer R, Kuhn RE. Effects of extracts of Trypanosoma cruzi on immune responses: induction of a nonspecific suppressor factor. Infect Immun. 1983 Sep; 41(3):978-86. PMID: 6411623; PMCID: PMC264597.
    134. Tarleton RL, Kuhn RE. Changes in cell populations and immunoglobulin-producing cells in the spleens of mice infected with Trypanosoma cruzi: correlations with parasite-specific antibody response. Cell Immunol. 1983 Sep; 80(2):392-404. PMID: 6411359.
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    135. Tarleton RL, Kuhn RE. Measurement of parasite-specific antibody responses using a tritiated avidin-solid phase radioimmunoassay. J Immunol Methods. 1983 May 27; 60(1-2):213-20. PMID: 6406603.
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    136. Cunningham DS, Kuhn RE, Tarleton RL, Dunn RS. Trypanosoma cruzi: effect on B-cell-responsive and -responding clones. Exp Parasitol. 1981 Apr; 51(2):257-68. PMID: 6781919.
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    137. Tarleton RL, Kuhn RE, Cunningham DS. Mitomycin C-treated Trypanosoma cruzi in vaccination of mice: induction of immunosuppression but not protection. Infect Immun. 1981 Feb; 31(2):693-7. PMID: 6783545; PMCID: PMC351365.
    138. Tarleton RL, Kemp WM. Demonstration of IgG-Fc and C3 receptors on adult Schistosoma mansoni. J Immunol. 1981 Jan; 126(1):379-84. PMID: 7451978.
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