Loading...
Header Logo
Keywords
Last Name
Institution

Dr Martha Sedegah

Title[no position]
Institution[no institution name]
Address[no address]
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Parra M, Liu X, Derrick SC, Yang A, Molina-Cruz A, Barillas-Mury C, Zheng H, Thao Pham P, Sedegah M, Belmonte A, Litilit DD, Waldmann TA, Kumar S, Morris SL, Perera LP. Co-expression of Interleukin-15 Enhances the Protective Immune Responses Induced by Immunization with a Murine Malaria MVA-Based Vaccine Encoding the Circumsporozoite Protein. PLoS One. 2015; 10(10):e0141141. PMID: 26505634; PMCID: PMC4624717.
    2. Maina EK, Bonney EY, Bukusi EA, Sedegah M, Lartey M, Ampofo WK. CD4+ T cell counts in initiation of antiretroviral therapy in HIV infected asymptomatic individuals; controversies and inconsistencies. Immunol Lett. 2015 Dec; 168(2):279-84. PMID: 26475399.
      View in: PubMed
    3. Aguiar JC, Bolton J, Wanga J, Sacci JB, Iriko H, Mazeika JK, Han ET, Limbach K, Patterson NB, Sedegah M, Cruz AM, Tsuboi T, Hoffman SL, Carucci D, Hollingdale MR, Villasante ED, Richie TL. Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for Vaccine Development. PLoS One. 2015; 10(8):e0136109. PMID: 26292257; PMCID: PMC4546230.
    4. Sedegah M, Hollingdale MR, Farooq F, Ganeshan H, Belmonte M, Huang J, Abot E, Limbach K, Chuang I, Tamminga C, Epstein JE, Villasante E. Controlled Human Malaria Infection (CHMI) differentially affects cell-mediated and antibody responses to CSP and AMA1 induced by adenovirus vaccines with and without DNA-priming. Hum Vaccin Immunother. 2015; 11(11):2705-15. PMID: 26292027; PMCID: PMC4685686.
    5. Ockenhouse CF, Regules J, Tosh D, Cowden J, Kathcart A, Cummings J, Paolino K, Moon J, Komisar J, Kamau E, Oliver T, Chhoeu A, Murphy J, Lyke K, Laurens M, Birkett A, Lee C, Weltzin R, Wille-Reece U, Sedegah M, Hendriks J, Versteege I, Pau MG, Sadoff J, Vanloubbeeck Y, Lievens M, Heerwegh D, Moris P, Guerra Mendoza Y, Jongert E, Cohen J, Voss G, Ballou WR, Vekemans J. Ad35.CS.01-RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy against Sporozoite Challenge in Healthy Malaria-Naïve Adults. PLoS One. 2015; 10(7):e0131571. PMID: 26148007; PMCID: PMC4492580.
    6. Anum D, Kusi KA, Ganeshan H, Hollingdale MR, Ofori MF, Koram KA, Gyan BA, Adu-Amankwah S, Badji E, Huang J, Belmonte M, Banania GJ, Kwofie TB, Villasante E, Dodoo D, Sedegah M. Measuring naturally acquired ex vivo IFN-? responses to Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites (CelTOS) in Ghanaian adults. Malar J. 2015 Jan 21; 14:20. PMID: 25604473; PMCID: PMC4308902.
    7. Sedegah M. The Ex Vivo IFN-? Enzyme-Linked Immunospot (ELISpot) Assay. Methods Mol Biol. 2015; 1325:197-205. PMID: 26450390.
      View in: PubMed
    8. Sedegah M, Hollingdale MR, Farooq F, Ganeshan H, Belmonte M, Kim Y, Peters B, Sette A, Huang J, McGrath S, Abot E, Limbach K, Shi M, Soisson L, Diggs C, Chuang I, Tamminga C, Epstein JE, Villasante E, Richie TL. Sterile immunity to malaria after DNA prime/adenovirus boost immunization is associated with effector memory CD8+T cells targeting AMA1 class I epitopes. PLoS One. 2014; 9(9):e106241. PMID: 25211344; PMCID: PMC4161338.
    9. Kusi KA, Bosomprah S, Dodoo D, Kyei-Baafour E, Dickson EK, Mensah D, Angov E, Dutta S, Sedegah M, Koram KA. Anti-sporozoite antibodies as alternative markers for malaria transmission intensity estimation. Malar J. 2014 Mar 17; 13:103. PMID: 24635830; PMCID: PMC3995447.
    10. Schwenk R, Banania G, Epstein J, Kim Y, Peters B, Belmonte M, Ganeshan H, Huang J, Reyes S, Stryhn A, Ockenhouse CF, Buus S, Richie TL, Sedegah M. Ex vivo tetramer staining and cell surface phenotyping for early activation markers CD38 and HLA-DR to enumerate and characterize malaria antigen-specific CD8+ T-cells induced in human volunteers immunized with a Plasmodium falciparum adenovirus-vectored malaria vaccine expressing AMA1. Malar J. 2013 Oct 29; 12:376. PMID: 24168370; PMCID: PMC3819688.
    11. Padte NN, Boente-Carrera M, Andrews CD, McManus J, Grasperge BF, Gettie A, Coelho-dos-Reis JG, Li X, Wu D, Bruder JT, Sedegah M, Patterson N, Richie TL, Wong CH, Ho DD, Vasan S, Tsuji M. A glycolipid adjuvant, 7DW8-5, enhances CD8+ T cell responses induced by an adenovirus-vectored malaria vaccine in non-human primates. PLoS One. 2013; 8(10):e78407. PMID: 24205224; PMCID: PMC3808339.
    12. Seder RA, Chang LJ, Enama ME, Zephir KL, Sarwar UN, Gordon IJ, Holman LA, James ER, Billingsley PF, Gunasekera A, Richman A, Chakravarty S, Manoj A, Velmurugan S, Li M, Ruben AJ, Li T, Eappen AG, Stafford RE, Plummer SH, Hendel CS, Novik L, Costner PJ, Mendoza FH, Saunders JG, Nason MC, Richardson JH, Murphy J, Davidson SA, Richie TL, Sedegah M, Sutamihardja A, Fahle GA, Lyke KE, Laurens MB, Roederer M, Tewari K, Epstein JE, Sim BK, Ledgerwood JE, Graham BS, Hoffman SL. Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine. Science. 2013 Sep 20; 341(6152):1359-65. PMID: 23929949.
      View in: PubMed
    13. Sedegah M, Kim Y, Ganeshan H, Huang J, Belmonte M, Abot E, Banania JG, Farooq F, McGrath S, Peters B, Sette A, Soisson L, Diggs C, Doolan DL, Tamminga C, Villasante E, Hollingdale MR, Richie TL. Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP). Malar J. 2013 Jun 05; 12:185. PMID: 23738590; PMCID: PMC3683343.
    14. Tamminga C, Sedegah M, Maiolatesi S, Fedders C, Reyes S, Reyes A, Vasquez C, Alcorta Y, Chuang I, Spring M, Kavanaugh M, Ganeshan H, Huang J, Belmonte M, Abot E, Belmonte A, Banania J, Farooq F, Murphy J, Komisar J, Richie NO, Bennett J, Limbach K, Patterson NB, Bruder JT, Shi M, Miller E, Dutta S, Diggs C, Soisson LA, Hollingdale MR, Epstein JE, Richie TL. Human adenovirus 5-vectored Plasmodium falciparum NMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection. Hum Vaccin Immunother. 2013 Oct; 9(10):2165-77. PMID: 23899517; PMCID: PMC3906401.
    15. Chuang I, Sedegah M, Cicatelli S, Spring M, Polhemus M, Tamminga C, Patterson N, Guerrero M, Bennett JW, McGrath S, Ganeshan H, Belmonte M, Farooq F, Abot E, Banania JG, Huang J, Newcomer R, Rein L, Litilit D, Richie NO, Wood C, Murphy J, Sauerwein R, Hermsen CC, McCoy AJ, Kamau E, Cummings J, Komisar J, Sutamihardja A, Shi M, Epstein JE, Maiolatesi S, Tosh D, Limbach K, Angov E, Bergmann-Leitner E, Bruder JT, Doolan DL, King CR, Carucci D, Dutta S, Soisson L, Diggs C, Hollingdale MR, Ockenhouse CF, Richie TL. DNA prime/Adenovirus boost malaria vaccine encoding P. falciparum CSP and AMA1 induces sterile protection associated with cell-mediated immunity. PLoS One. 2013; 8(2):e55571. PMID: 23457473; PMCID: PMC3573028.
    16. Richie TL, Charoenvit Y, Wang R, Epstein JE, Hedstrom RC, Kumar S, Luke TC, Freilich DA, Aguiar JC, Sacci JB, Sedegah M, Nosek RA, De La Vega P, Berzins MP, Majam VF, Abot EN, Ganeshan H, Richie NO, Banania JG, Baraceros MF, Geter TG, Mere R, Bebris L, Limbach K, Hickey BW, Lanar DE, Ng J, Shi M, Hobart PM, Norman JA, Soisson LA, Hollingdale MR, Rogers WO, Doolan DL, Hoffman SL. Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA. Hum Vaccin Immunother. 2012 Nov 01; 8(11):1564-84. PMID: 23151451; PMCID: PMC3601132.
    17. Mahajan B, Zheng H, Pham PT, Sedegah MY, Majam VF, Akolkar N, Rios M, Ankrah I, Madjitey P, Amoah G, Addison E, Quakyi IA, Kumar S. Polymerase chain reaction-based tests for pan-species and species-specific detection of human Plasmodium parasites. Transfusion. 2012 Sep; 52(9):1949-56. PMID: 22320188.
      View in: PubMed
    18. Tamminga C, Sedegah M, Regis D, Chuang I, Epstein JE, Spring M, Mendoza-Silveiras J, McGrath S, Maiolatesi S, Reyes S, Steinbeiss V, Fedders C, Smith K, House B, Ganeshan H, Lejano J, Abot E, Banania GJ, Sayo R, Farooq F, Belmonte M, Murphy J, Komisar J, Williams J, Shi M, Brambilla D, Manohar N, Richie NO, Wood C, Limbach K, Patterson NB, Bruder JT, Doolan DL, King CR, Diggs C, Soisson L, Carucci D, Levine G, Dutta S, Hollingdale MR, Ockenhouse CF, Richie TL. Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component. PLoS One. 2011; 6(10):e25868. PMID: 22003411; PMCID: PMC3189219.
    19. Sedegah M, Tamminga C, McGrath S, House B, Ganeshan H, Lejano J, Abot E, Banania GJ, Sayo R, Farooq F, Belmonte M, Manohar N, Richie NO, Wood C, Long CA, Regis D, Williams FT, Shi M, Chuang I, Spring M, Epstein JE, Mendoza-Silveiras J, Limbach K, Patterson NB, Bruder JT, Doolan DL, King CR, Soisson L, Diggs C, Carucci D, Dutta S, Hollingdale MR, Ockenhouse CF, Richie TL. Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults. PLoS One. 2011; 6(10):e24586. PMID: 22003383; PMCID: PMC3189181.
    20. Epstein JE, Tewari K, Lyke KE, Sim BK, Billingsley PF, Laurens MB, Gunasekera A, Chakravarty S, James ER, Sedegah M, Richman A, Velmurugan S, Reyes S, Li M, Tucker K, Ahumada A, Ruben AJ, Li T, Stafford R, Eappen AG, Tamminga C, Bennett JW, Ockenhouse CF, Murphy JR, Komisar J, Thomas N, Loyevsky M, Birkett A, Plowe CV, Loucq C, Edelman R, Richie TL, Seder RA, Hoffman SL. Live attenuated malaria vaccine designed to protect through hepatic CD8? T cell immunity. Science. 2011 Oct 28; 334(6055):475-80. PMID: 21903775.
      View in: PubMed
    21. Dodoo D, Hollingdale MR, Anum D, Koram KA, Gyan B, Akanmori BD, Ocran J, Adu-Amankwah S, Geneshan H, Abot E, Legano J, Banania G, Sayo R, Brambilla D, Kumar S, Doolan DL, Rogers WO, Epstein J, Richie TL, Sedegah M. Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults. Malar J. 2011 Jun 20; 10:168. PMID: 21689436; PMCID: PMC3132199.
    22. Limbach K, Aguiar J, Gowda K, Patterson N, Abot E, Sedegah M, Sacci J, Richie T. Identification of two new protective pre-erythrocytic malaria vaccine antigen candidates. Malar J. 2011 Mar 16; 10:65. PMID: 21410955; PMCID: PMC3073953.
    23. Sedegah M, Kim Y, Peters B, McGrath S, Ganeshan H, Lejano J, Abot E, Banania G, Belmonte M, Sayo R, Farooq F, Doolan DL, Regis D, Tamminga C, Chuang I, Bruder JT, King CR, Ockenhouse CF, Faber B, Remarque E, Hollingdale MR, Richie TL, Sette A. Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein. Malar J. 2010 Aug 24; 9:241. PMID: 20735847; PMCID: PMC2939619.
    24. Hoffman SL, Billingsley PF, James E, Richman A, Loyevsky M, Li T, Chakravarty S, Gunasekera A, Chattopadhyay R, Li M, Stafford R, Ahumada A, Epstein JE, Sedegah M, Reyes S, Richie TL, Lyke KE, Edelman R, Laurens MB, Plowe CV, Sim BK. Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria. Hum Vaccin. 2010 Jan; 6(1):97-106. PMID: 19946222.
      View in: PubMed
    25. Sedegah M, Rogers WO, Belmonte M, Belmonte A, Banania G, Patterson NB, Rusalov D, Ferrari M, Richie TL, Doolan DL. Vaxfectin enhances both antibody and in vitro T cell responses to each component of a 5-gene Plasmodium falciparum plasmid DNA vaccine mixture administered at low doses. Vaccine. 2010 Apr 09; 28(17):3055-65. PMID: 19879998.
      View in: PubMed
    26. Dobaño C, Sedegah M, Rogers WO, Kumar S, Zheng H, Hoffman SL, Doolan DL. Plasmodium: mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunity. Exp Parasitol. 2009 Jun; 122(2):112-23. PMID: 19249301.
      View in: PubMed
    27. Sedegah M, Weiss WW, Hoffman SL. Cross-protection between attenuated Plasmodium berghei and P. yoelii sporozoites. Parasite Immunol. 2007 Nov; 29(11):559-65. PMID: 17944745; PMCID: PMC2955969.
    28. Chen L, Ewing D, Subramanian H, Block K, Rayner J, Alterson KD, Sedegah M, Hayes C, Porter K, Raviprakash K. A heterologous DNA prime-Venezuelan equine encephalitis virus replicon particle boost dengue vaccine regimen affords complete protection from virus challenge in cynomolgus macaques. J Virol. 2007 Nov; 81(21):11634-9. PMID: 17715224; PMCID: PMC2168814.
    29. Brice GT, Dobaño C, Sedegah M, Stefaniak M, Graber NL, Campo JJ, Carucci DJ, Doolan DL. Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines. Microbes Infect. 2007 Oct; 9(12-13):1439-46. PMID: 17913540.
      View in: PubMed
    30. Epstein JE, Rao S, Williams F, Freilich D, Luke T, Sedegah M, de la Vega P, Sacci J, Richie TL, Hoffman SL. Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update. J Infect Dis. 2007 Jul 01; 196(1):145-54. PMID: 17538895.
      View in: PubMed
    31. Bacon DJ, Sedegah M. Reduced production of RNA transcripts from individual DNA plasmids given in a multivalent DNA vaccine formula. Hum Vaccin. 2007 Mar-Apr; 3(2):48-53. PMID: 17312401.
      View in: PubMed
    32. Sedegah M, Hoffman SL. Immunological responses of neonates and infants to DNA vaccines. Methods Mol Med. 2006; 127:239-51. PMID: 16988458.
      View in: PubMed
    33. Sedegah M, Rogers WO, Belmonte A, Belmonte M, Banania G, Patterson N, Ferrari M, Kaslow DC, Carucci DJ, Richie TL, Doolan DL. Vaxfectin enhances immunogenicity and protective efficacy of P. yoelii circumsporozoite DNA vaccines. Vaccine. 2006 Mar 10; 24(11):1921-7. PMID: 16298024.
      View in: PubMed
    34. Sedegah M, Charoenvit Y, Aguiar J, Sacci J, Hedstrom R, Kumar S, Belmonte A, Lanar DE, Jones TR, Abot E, Druilhe P, Corradin G, Epstein JE, Richie TL, Carucci DJ, Hoffman SL. Effect on antibody and T-cell responses of mixing five GMP-produced DNA plasmids and administration with plasmid expressing GM-CSF. Genes Immun. 2004 Nov; 5(7):553-61. PMID: 15318164.
      View in: PubMed
    35. Charoenvit Y, Brice GT, Bacon D, Majam V, Williams J, Abot E, Ganeshan H, Sedegah M, Doolan DL, Carucci DJ, Zimmerman DH. A small peptide (CEL-1000) derived from the beta-chain of the human major histocompatibility complex class II molecule induces complete protection against malaria in an antigen-independent manner. Antimicrob Agents Chemother. 2004 Jul; 48(7):2455-63. PMID: 15215094; PMCID: PMC434180.
    36. Sedegah M, Charoenvit Y, Minh L, Belmonte M, Majam VF, Abot S, Ganeshan H, Kumar S, Bacon DJ, Stowers A, Narum DL, Carucci DJ, Rogers WO. Reduced immunogenicity of DNA vaccine plasmids in mixtures. Gene Ther. 2004 Mar; 11(5):448-56. PMID: 14973538.
      View in: PubMed
    37. Sedegah M, Belmonte M, Epstein JE, Siegrist CA, Weiss WR, Jones TR, Lu M, Carucci DJ, Hoffman SL. Successful induction of CD8 T cell-dependent protection against malaria by sequential immunization with DNA and recombinant poxvirus of neonatal mice born to immune mothers. J Immunol. 2003 Sep 15; 171(6):3148-53. PMID: 12960342.
      View in: PubMed
    38. Fanning SL, Czesny B, Sedegah M, Carucci DJ, van Gemert GJ, Eling W, Williamson KC. A glycosylphosphatidylinositol anchor signal sequence enhances the immunogenicity of a DNA vaccine encoding Plasmodium falciparum sexual-stage antigen, Pfs230. Vaccine. 2003 Jul 04; 21(23):3228-35. PMID: 12804852.
      View in: PubMed
    39. Belmonte M, Jones TR, Lu M, Arcilla R, Smalls T, Belmonte A, Rosenbloom J, Carucci DJ, Sedegah M. The infectivity of Plasmodium yoelii in different strains of mice. J Parasitol. 2003 Jun; 89(3):602-3. PMID: 12880263.
      View in: PubMed
    40. Carlton JM, Angiuoli SV, Suh BB, Kooij TW, Pertea M, Silva JC, Ermolaeva MD, Allen JE, Selengut JD, Koo HL, Peterson JD, Pop M, Kosack DS, Shumway MF, Bidwell SL, Shallom SJ, van Aken SE, Riedmuller SB, Feldblyum TV, Cho JK, Quackenbush J, Sedegah M, Shoaibi A, Cummings LM, Florens L, Yates JR, Raine JD, Sinden RE, Harris MA, Cunningham DA, Preiser PR, Bergman LW, Vaidya AB, van Lin LH, Janse CJ, Waters AP, Smith HO, White OR, Salzberg SL, Venter JC, Fraser CM, Hoffman SL, Gardner MJ, Carucci DJ. Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature. 2002 Oct 03; 419(6906):512-9. PMID: 12368865.
      View in: PubMed
    41. Sedegah M, Brice GT, Rogers WO, Doolan DL, Charoenvit Y, Jones TR, Majam VF, Belmonte A, Lu M, Belmonte M, Carucci DJ, Hoffman SL. Persistence of protective immunity to malaria induced by DNA priming and poxvirus boosting: characterization of effector and memory CD8(+)-T-cell populations. Infect Immun. 2002 Jul; 70(7):3493-9. PMID: 12065488; PMCID: PMC128102.
    42. Hoffman SL, Goh LM, Luke TC, Schneider I, Le TP, Doolan DL, Sacci J, de la Vega P, Dowler M, Paul C, Gordon DM, Stoute JA, Church LW, Sedegah M, Heppner DG, Ballou WR, Richie TL. Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites. J Infect Dis. 2002 Apr 15; 185(8):1155-64. PMID: 11930326.
      View in: PubMed
    43. Sanchez GI, Sedegah M, Rogers WO, Jones TR, Sacci J, Witney A, Carucci DJ, Kumar N, Hoffman SL. Immunogenicity and protective efficacy of a Plasmodium yoelii Hsp60 DNA vaccine in BALB/c mice. Infect Immun. 2001 Jun; 69(6):3897-905. PMID: 11349057; PMCID: PMC98419.
    44. Gramzinski RA, Doolan DL, Sedegah M, Davis HL, Krieg AM, Hoffman SL. Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice. Infect Immun. 2001 Mar; 69(3):1643-9. PMID: 11179339; PMCID: PMC98068.
    45. Haddad D, Ramprakash J, Sedegah M, Charoenvit Y, Baumgartner R, Kumar S, Hoffman SL, Weiss WR. Plasmid vaccine expressing granulocyte-macrophage colony-stimulating factor attracts infiltrates including immature dendritic cells into injected muscles. J Immunol. 2000 Oct 01; 165(7):3772-81. PMID: 11034382.
      View in: PubMed
    46. Charest H, Sedegah M, Yap GS, Gazzinelli RT, Caspar P, Hoffman SL, Sher A. Recombinant attenuated Toxoplasma gondii expressing the Plasmodium yoelii circumsporozoite protein provides highly effective priming for CD8+ T cell-dependent protective immunity against malaria. J Immunol. 2000 Aug 15; 165(4):2084-92. PMID: 10925293.
      View in: PubMed
    47. Sedegah M, Weiss W, Sacci JB, Charoenvit Y, Hedstrom R, Gowda K, Majam VF, Tine J, Kumar S, Hobart P, Hoffman SL. Improving protective immunity induced by DNA-based immunization: priming with antigen and GM-CSF-encoding plasmid DNA and boosting with antigen-expressing recombinant poxvirus. J Immunol. 2000 Jun 01; 164(11):5905-12. PMID: 10820272.
      View in: PubMed
    48. Le TP, Coonan KM, Hedstrom RC, Charoenvit Y, Sedegah M, Epstein JE, Kumar S, Wang R, Doolan DL, Maguire JD, Parker SE, Hobart P, Norman J, Hoffman SL. Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers. Vaccine. 2000 Mar 17; 18(18):1893-901. PMID: 10699338.
      View in: PubMed
    49. Wang R, Doolan DL, Le TP, Hedstrom RC, Coonan KM, Charoenvit Y, Jones TR, Hobart P, Margalith M, Ng J, Weiss WR, Sedegah M, de Taisne C, Norman JA, Hoffman SL. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science. 1998 Oct 16; 282(5388):476-80. PMID: 9774275.
      View in: PubMed
    50. Wang R, Doolan DL, Charoenvit Y, Hedstrom RC, Gardner MJ, Hobart P, Tine J, Sedegah M, Fallarme V, Sacci JB, Kaur M, Klinman DM, Hoffman SL, Weiss WR. Simultaneous induction of multiple antigen-specific cytotoxic T lymphocytes in nonhuman primates by immunization with a mixture of four Plasmodium falciparum DNA plasmids. Infect Immun. 1998 Sep; 66(9):4193-202. PMID: 9712767; PMCID: PMC108505.
    51. Weiss WR, Ishii KJ, Hedstrom RC, Sedegah M, Ichino M, Barnhart K, Klinman DM, Hoffman SL. A plasmid encoding murine granulocyte-macrophage colony-stimulating factor increases protection conferred by a malaria DNA vaccine. J Immunol. 1998 Sep 01; 161(5):2325-32. PMID: 9725227.
      View in: PubMed
    52. Hedstrom RC, Doolan DL, Wang R, Kumar A, Sacci JB, Gardner MJ, Aguiar JC, Charoenvit Y, Sedegah M, Tine JA, Margalith M, Hobart P, Hoffman SL. In vitro expression and in vivo immunogenicity of Plasmodium falciparum pre-erythrocytic stage DNA vaccines. Int J Mol Med. 1998 Jul; 2(1):29-38. PMID: 9854139.
      View in: PubMed
    53. Sedegah M, Jones TR, Kaur M, Hedstrom R, Hobart P, Tine JA, Hoffman SL. Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7648-53. PMID: 9636204; PMCID: PMC22711.
    54. Doolan DL, Hedstrom RC, Gardner MJ, Sedegah M, Wang H, Gramzinski RA, Margalith M, Hobart P, Hoffman SL. DNA vaccination as an approach to malaria control: current status and strategies. Curr Top Microbiol Immunol. 1998; 226:37-56. PMID: 9479834.
      View in: PubMed
    55. Doolan DL, Hedstrom RC, Wang R, Sedegah M, Scheller LF, Hobart P, Norman JA, Hoffman SL. DNA vaccines for malaria: the past, the present, & the future. Indian J Med Res. 1997 Aug; 106:109-19. PMID: 9291681.
      View in: PubMed
    56. Hoffman SL, Doolan DL, Sedegah M, Wang R, Scheller LF, Kumar A, Weiss WR, Le TP, Klinman DM, Hobart P, Norman JA, Hedstrom RC. Toward clinical trials of DNA vaccines against malaria. Immunol Cell Biol. 1997 Aug; 75(4):376-81. PMID: 9315481.
      View in: PubMed
    57. Gramzinski RA, Maris DC, Doolan D, Charoenvit Y, Obaldia N, Rossan R, Sedegah M, Wang R, Hobart P, Margalith M, Hoffman S. Malaria DNA vaccines in Aotus monkeys. Vaccine. 1997 Jun; 15(8):913-5. PMID: 9234546.
      View in: PubMed
    58. Hoffman SL, Doolan DL, Sedegah M, Aguiar JC, Wang R, Malik A, Gramzinski RA, Weiss WR, Hobart P, Norman JA, Margalith M, Hedstrom RC. Strategy for development of a pre-erythrocytic Plasmodium falciparum DNA vaccine for human use. Vaccine. 1997 Jun; 15(8):842-5. PMID: 9234529.
      View in: PubMed
    59. Hoffman SL, Crutcher JM, Puri SK, Ansari AA, Villinger F, Franke ED, Singh PP, Finkelman F, Gately MK, Dutta GP, Sedegah M. Sterile protection of monkeys against malaria after administration of interleukin-12. Nat Med. 1997 Jan; 3(1):80-3. PMID: 8986746.
      View in: PubMed
    60. Hedstrom RC, Doolan DL, Wang R, Gardner MJ, Kumar A, Sedegah M, Gramzinski RA, Sacci JB, Charoenvit Y, Weiss WR, Margalith M, Norman JA, Hobart P, Hoffman SL. The development of a multivalent DNA vaccine for malaria. Springer Semin Immunopathol. 1997; 19(2):147-59. PMID: 9406343.
      View in: PubMed
    61. Mor G, Yamshchikov G, Sedegah M, Takeno M, Wang R, Houghten RA, Hoffman S, Klinman DM. Induction of neonatal tolerance by plasmid DNA vaccination of mice. J Clin Invest. 1996 Dec 15; 98(12):2700-5. PMID: 8981914; PMCID: PMC507733.
    62. Gardner MJ, Doolan DL, Hedstrom RC, Wang R, Sedegah M, Gramzinski RA, Aguiar JC, Wang H, Margalith M, Hobart P, Hoffman SL. DNA vaccines against malaria: immunogenicity and protection in a rodent model. J Pharm Sci. 1996 Dec; 85(12):1294-300. PMID: 8961142.
      View in: PubMed
    63. Doolan DL, Sedegah M, Hedstrom RC, Hobart P, Charoenvit Y, Hoffman SL. Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8+ cell-, interferon gamma-, and nitric oxide-dependent immunity. J Exp Med. 1996 Apr 01; 183(4):1739-46. PMID: 8666931; PMCID: PMC2192484.
    64. Hoffman SL, Doolan DL, Sedegah M, Gramzinski R, Wang H, Gowda K, Hobart P, Margalith M, Norman J, Hedstrom RC. Nucleic acid malaria vaccines. Current status and potential. Ann N Y Acad Sci. 1995 Nov 27; 772:88-94. PMID: 8546416.
      View in: PubMed
    65. Crutcher JM, Stevenson MM, Sedegah M, Hoffman SL. Interleukin-12 and malaria. Res Immunol. 1995 Sep-Oct; 146(7-8):552-9. PMID: 8839161.
      View in: PubMed
    66. Mor G, Klinman DM, Shapiro S, Hagiwara E, Sedegah M, Norman JA, Hoffman SL, Steinberg AD. Complexity of the cytokine and antibody response elicited by immunizing mice with Plasmodium yoelii circumsporozoite protein plasmid DNA. J Immunol. 1995 Aug 15; 155(4):2039-46. PMID: 7636255.
      View in: PubMed
    67. Charoenvit Y, Mellouk S, Sedegah M, Toyoshima T, Leef MF, De la Vega P, Beaudoin RL, Aikawa M, Fallarme V, Hoffman SL. Plasmodium yoelii: 17-kDa hepatic and erythrocytic stage protein is the target of an inhibitory monoclonal antibody. Exp Parasitol. 1995 May; 80(3):419-29. PMID: 7729477.
      View in: PubMed
    68. Wang HH, Rogers WO, Kang YH, Sedegah M, Hoffman SL. Partial protection against malaria by immunization with Leishmania enriettii expressing the Plasmodium yoelii circumsporozoite protein. Mol Biochem Parasitol. 1995 Feb; 69(2):139-48. PMID: 7770079.
      View in: PubMed
    69. Hoffman SL, Sedegah M, Hedstrom RC. Protection against malaria by immunization with a Plasmodium yoelii circumsporozoite protein nucleic acid vaccine. Vaccine. 1994 Dec; 12(16):1529-33. PMID: 7879419.
      View in: PubMed
    70. Hoffman SL, Edelman R, Bryan JP, Schneider I, Davis J, Sedegah M, Gordon D, Church P, Gross M, Silverman C, et al. Safety, immunogenicity, and efficacy of a malaria sporozoite vaccine administered with monophosphoryl lipid A, cell wall skeleton of mycobacteria, and squalane as adjuvant. Am J Trop Med Hyg. 1994 Nov; 51(5):603-12. PMID: 7985753.
      View in: PubMed
    71. Sedegah M, Finkelman F, Hoffman SL. Interleukin 12 induction of interferon gamma-dependent protection against malaria. Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10700-2. PMID: 7938013; PMCID: PMC45089.
    72. Sedegah M, Hedstrom R, Hobart P, Hoffman SL. Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc Natl Acad Sci U S A. 1994 Oct 11; 91(21):9866-70. PMID: 7937907; PMCID: PMC44918.
    73. Siu NF, Sedegah M, Hoffman SL. In vitro survival and retention of infectivity of Plasmodium yoelii sporozoites over extended periods of time. J Parasitol. 1994 Oct; 80(5):826-9. PMID: 7931920.
      View in: PubMed
    74. Hedstrom RC, Sedegah M, Hoffman SL. Prospects and strategies for development of DNA vaccines against malaria. Res Immunol. 1994 Jul-Aug; 145(6):476-83. PMID: 7899711.
      View in: PubMed
    75. Khusmith S, Sedegah M, Hoffman SL. Complete protection against Plasmodium yoelii by adoptive transfer of a CD8+ cytotoxic T-cell clone recognizing sporozoite surface protein 2. Infect Immun. 1994 Jul; 62(7):2979-83. PMID: 8005684; PMCID: PMC302907.
    76. Hoffman SL, Sedegah M, Malik A. Cytotoxic T lymphocytes in humans exposed to Plasmodium falciparum by immunization or natural exposure. Curr Top Microbiol Immunol. 1994; 189:187-203. PMID: 7924436.
      View in: PubMed
    77. Weiss WR, Sedegah M, Berzofsky JA, Hoffman SL. The role of CD4+ T cells in immunity to malaria sporozoites. J Immunol. 1993 Sep 01; 151(5):2690-8. PMID: 8103069.
      View in: PubMed
    78. Ak M, Bower JH, Hoffman SL, Sedegah M, Lees A, Carter M, Beaudoin RL, Charoenvit Y. Monoclonal antibodies of three different immunoglobulin G isotypes produced by immunization with a synthetic peptide or native protein protect mice against challenge with Plasmodium yoelii sporozoites. Infect Immun. 1993 Jun; 61(6):2493-7. PMID: 8500885; PMCID: PMC280874.
    79. Weiss WR, Berzofsky JA, Houghten RA, Sedegah M, Hollindale M, Hoffman SL. A T cell clone directed at the circumsporozoite protein which protects mice against both Plasmodium yoelii and Plasmodium berghei. J Immunol. 1992 Sep 15; 149(6):2103-9. PMID: 1517574.
      View in: PubMed
    80. Sedegah M, Sim BK, Mason C, Nutman T, Malik A, Roberts C, Johnson A, Ochola J, Koech D, Were B, et al. Naturally acquired CD8+ cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein. J Immunol. 1992 Aug 01; 149(3):966-71. PMID: 1634778.
      View in: PubMed
    81. Sedegah M, Chiang CH, Weiss WR, Mellouk S, Cochran MD, Houghten RA, Beaudoin RL, Smith D, Hoffman SL. Recombinant pseudorabies virus carrying a plasmodium gene: herpesvirus as a new live viral vector for inducing T- and B-cell immunity. Vaccine. 1992; 10(9):578-84. PMID: 1323900.
      View in: PubMed
    82. Londoño JA, Sedegah M, Charoenvit Y, Beaudoin RL, Druilhe P. Antigenic analysis of Plasmodium yoelii liver stages by fluorescence antibody assays. Trop Med Parasitol. 1991 Dec; 42(4):381-5. PMID: 1724570.
      View in: PubMed
    83. Khusmith S, Charoenvit Y, Kumar S, Sedegah M, Beaudoin RL, Hoffman SL. Protection against malaria by vaccination with sporozoite surface protein 2 plus CS protein. Science. 1991 May 03; 252(5006):715-8. PMID: 1827210.
      View in: PubMed
    84. Charoenvit Y, Mellouk S, Cole C, Bechara R, Leef MF, Sedegah M, Yuan LF, Robey FA, Beaudoin RL, Hoffman SL. Monoclonal, but not polyclonal, antibodies protect against Plasmodium yoelii sporozoites. J Immunol. 1991 Feb 01; 146(3):1020-5. PMID: 1988490.
      View in: PubMed
    85. Hoffman SL, Weiss W, Mellouk S, Sedegah M. Irradiated sporozoite vaccine induces cytotoxic T lymphocytes that recognize malaria antigens on the surface of infected hepatocytes. Immunol Lett. 1990 Aug; 25(1-3):33-8. PMID: 2283160.
      View in: PubMed
    86. Mellouk S, Lunel F, Sedegah M, Beaudoin RL, Druilhe P. Protection against malaria induced by irradiated sporozoites. Lancet. 1990 Mar 24; 335(8691):721. PMID: 1969073.
      View in: PubMed
    87. Weiss WR, Mellouk S, Houghten RA, Sedegah M, Kumar S, Good MF, Berzofsky JA, Miller LH, Hoffman SL. Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes. J Exp Med. 1990 Mar 01; 171(3):763-73. PMID: 1689762; PMCID: PMC2187765.
    88. Hedstrom RC, Campbell JR, Leef ML, Charoenvit Y, Carter M, Sedegah M, Beaudoin RL, Hoffman SL. A malaria sporozoite surface antigen distinct from the circumsporozoite protein. Bull World Health Organ. 1990; 68 Suppl:152-7. PMID: 2094580; PMCID: PMC2393018.
    89. Aikawa M, Atkinson CT, Beaudoin LM, Sedegah M, Charoenvit Y, Beaudoin R. Localization of CS and non-CS antigens in the sporogonic stages of Plasmodium yoelii. Bull World Health Organ. 1990; 68 Suppl:165-71. PMID: 2094581; PMCID: PMC2393049.
    90. Mellouk S, Berbiguier N, Druilhe P, Sedegah M, Galey B, Yuan L, Leef M, Charoenvit Y, Paul C, Hoffman S, et al. Evaluation of an in vitro assay aimed at measuring protective antibodies against sporozoites. Bull World Health Organ. 1990; 68 Suppl:52-9. PMID: 2094592; PMCID: PMC2393043.
    91. Hoffman SL, Isenbarger D, Long GW, Sedegah M, Szarfman A, Mellouk S, Ballou WR. T lymphocytes from mice immunized with irradiated sporozoites eliminate malaria from hepatocytes. Bull World Health Organ. 1990; 68 Suppl:132-7. PMID: 2151270; PMCID: PMC2393038.
    92. Sedegah M, Beaudoin RL, Majarian WR, Cochran MD, Chiang CH, Sadoff J, Aggarwal A, Charoenvit Y, Hoffman SL. Evaluation of vaccines designed to induce protective cellular immunity against the Plasmodium yoelii circumsporozoite protein: vaccinia, pseudorabies, and Salmonella transformed with circumsporozoite gene. Bull World Health Organ. 1990; 68 Suppl:109-14. PMID: 2094576; PMCID: PMC2393047.
    93. Charoenvit Y, Sedegah M, Yuan LF, Gross M, Cole C, Bechara R, Leef MF, Robey FA, Lowell GH, Beaudoin RL. Active and passive immunization against Plasmodium yoelii sporozoites. Bull World Health Organ. 1990; 68 Suppl:26-32. PMID: 1709834; PMCID: PMC2393042.
    94. Hoffman SL, Isenbarger D, Long GW, Sedegah M, Szarfman A, Waters L, Hollingdale MR, van der Meide PH, Finbloom DS, Ballou WR. Sporozoite vaccine induces genetically restricted T cell elimination of malaria from hepatocytes. Science. 1989 Jun 02; 244(4908):1078-81. PMID: 2524877.
      View in: PubMed
    95. Wortman A, Rogers P, Charoenvit Y, McDermott A, Leef M, Sedegah M, Beaudoin RL. Cloning of Plasmodium yoelii genes expressing three different sporozoite-specific antigens. Microb Pathog. 1989 Mar; 6(3):227-31. PMID: 2472543.
      View in: PubMed
    96. Weiss WR, Sedegah M, Beaudoin RL, Miller LH, Good MF. CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites. Proc Natl Acad Sci U S A. 1988 Jan; 85(2):573-6. PMID: 2963334; PMCID: PMC279593.
    97. Sedegah M, Leef MF, Matheny S, Beaudoin RL. A rapid method for screening antibodies to Plasmodium yoelii liver stages by immunofluorescence. J Parasitol. 1987 Dec; 73(6):1268-70. PMID: 3325624.
      View in: PubMed
    98. Charoenvit Y, Leef MF, Yuan LF, Sedegah M, Beaudoin RL. Characterization of Plasmodium yoelii monoclonal antibodies directed against stage-specific sporozoite antigens. Infect Immun. 1987 Mar; 55(3):604-8. PMID: 2434426; PMCID: PMC260381.
    99. Sedegah M, Tosta CE, Henderson DC, Wedderburn N. Cross-reactivity and cross-protection in murine malaria. Ann Trop Med Parasitol. 1982 Apr; 76(2):219-21. PMID: 7046657.
      View in: PubMed
    100. Tosta CE, Sedegah M, Henderson DC, Wedderburn N. Plasmodium yoelii and Plasmodium berghei: isolation of infected erythrocytes from blood by colloidal silica gradient centrifugation. Exp Parasitol. 1980 Aug; 50(1):7-15. PMID: 6248355.
      View in: PubMed
    Sedegah's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description