Loading...
Header Logo
Keywords
Last Name
Institution

Dr Mahmoud El Kouni

AddressBirmingham 35294
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. El Kouni MH. Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets. Comp Biochem Physiol B Biochem Mol Biol. 2017 Nov; 213:55-80. PMID: 28735972.
      View in: PubMed
    2. Naguib FN, Rais RH, Al Safarjalani ON, el Kouni MH. Kinetic mechanism of Toxoplasma gondii adenosine kinase and the highly efficient utilization of adenosine. Comp Biochem Physiol B Biochem Mol Biol. 2015 Oct; 188:63-9. PMID: 26112826.
      View in: PubMed
    3. Savarese TM, El Kouni MH. Isolation and substrate specificity of an adenine nucleoside phosphorylase from adult Schistosoma mansoni. Mol Biochem Parasitol. 2014 Mar-Apr; 194(1-2):44-7. PMID: 24794680.
      View in: PubMed
    4. Naguib FN, El Kouni MH. Nucleoside kinases in adult Schistosoma mansoni: phosphorylation of pyrimidine nucleosides. Mol Biochem Parasitol. 2014 Mar-Apr; 194(1-2):53-5. PMID: 24786512.
      View in: PubMed
    5. Van Duyne R, Guendel I, Jaworski E, Sampey G, Klase Z, Chen H, Zeng C, Kovalskyy D, El Kouni MH, Lepene B, Patanarut A, Nekhai S, Price DH, Kashanchi F. Effect of mimetic CDK9 inhibitors on HIV-1-activated transcription. J Mol Biol. 2013 Feb 22; 425(4):812-29. PMID: 23247501.
      View in: PubMed
    6. Al Safarjalani ON, Rais R, Naguib FN, el Kouni MH. Potent combination therapy for human breast tumors with high doses of 5-fluorouracil: remission and lack of host toxicity. Cancer Chemother Pharmacol. 2012 Jun; 69(6):1449-55. PMID: 22373605.
      View in: PubMed
    7. Pula G, Garonna E, Dunn WB, Hirano M, Pizzorno G, Campanella M, Schwartz EL, El Kouni MH, Wheeler-Jones CP. Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2631-8. PMID: 20884872.
      View in: PubMed
    8. Al Safarjalani ON, Rais RH, Kim YA, Chu CK, Naguib FN, El Kouni MH. Carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase: biological activities and selective toxicities. Biochem Pharmacol. 2010 Oct 01; 80(7):955-63. PMID: 20541538.
      View in: PubMed
    9. Kim YA, Rawal RK, Yoo J, Sharon A, Jha AK, Chu CK, Rais RH, Al Safarjalani ON, Naguib FN, El Kouni MH. Structure-activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase. Bioorg Med Chem. 2010 May 15; 18(10):3403-12. PMID: 20456959.
      View in: PubMed
    10. Al Safarjalani ON, Rais RH, Kim YA, Chu CK, Naguib FN, el Kouni MH. 7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities. Biochem Pharmacol. 2008 Oct 15; 76(8):958-66. PMID: 18755159.
      View in: PubMed
    11. Kim YA, Sharon A, Chu CK, Rais RH, Al Safarjalani ON, Naguib FN, el Kouni MH. Structure-activity relationships of 7-deaza-6-benzylthioinosine analogues as ligands of Toxoplasma gondii adenosine kinase. J Med Chem. 2008 Jul 10; 51(13):3934-45. PMID: 18563892.
      View in: PubMed
    12. Choi JW, Shin CY, Choi MS, Yoon SY, Ryu JH, Lee JC, Kim WK, El Kouni MH, Ko KH. Uridine protects cortical neurons from glucose deprivation-induced death: possible role of uridine phosphorylase. J Neurotrauma. 2008 Jun; 25(6):695-707. PMID: 18457515.
      View in: PubMed
    13. Guarcello V, Blanquicett C, Naguib FN, El Kouni MH. Suppression of thymidine phosphorylase expression by promoter methylation in human cancer cells lacking enzyme activity. Cancer Chemother Pharmacol. 2008 Jun; 62(1):85-96. PMID: 17805539.
      View in: PubMed
    14. Kim YA, Sharon A, Chu CK, Rais RH, Al Safarjalani ON, Naguib FN, el Kouni MH. Synthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents. Biochem Pharmacol. 2007 May 15; 73(10):1558-72. PMID: 17306769.
      View in: PubMed
    15. Zhang Y, El Kouni MH, Ealick SE. Substrate analogs induce an intermediate conformational change in Toxoplasma gondii adenosine kinase. Acta Crystallogr D Biol Crystallogr. 2007 Feb; 63(Pt 2):126-34. PMID: 17242506.
      View in: PubMed
    16. el Kouni MH. Adenosine metabolism in Toxoplasma gondii: potential targets for chemotherapy. Curr Pharm Des. 2007; 13(6):581-97. PMID: 17346176.
      View in: PubMed
    17. Choi JW, Yoo BK, Shin CY, Ryu MK, Ryu JH, el Kouni MH, Lee JC, Kim WK, Ko KH. Uridine prevents the glucose deprivation-induced death of immunostimulated astrocytes via the action of uridine phosphorylase. Neurosci Res. 2006 Sep; 56(1):111-8. PMID: 16839635.
      View in: PubMed
    18. Al Safarjalani ON, Rais R, Shi J, Schinazi RF, Naguib FN, el Kouni MH. Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor. Cancer Chemother Pharmacol. 2006 Nov; 58(5):692-8. PMID: 16528530.
      View in: PubMed
    19. Zhang Y, El Kouni MH, Ealick SE. Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 angstroms resolution. Acta Crystallogr D Biol Crystallogr. 2006 Feb; 62(Pt 2):140-5. PMID: 16421444.
      View in: PubMed
    20. Gupte A, Buolamwini JK, Yadav V, Chu CK, Naguib FN, el Kouni MH. 6-Benzylthioinosine analogues: promising anti-toxoplasmic agents as inhibitors of the mammalian nucleoside transporter ENT1 (es). Biochem Pharmacol. 2005 Dec 19; 71(1-2):69-73. PMID: 16310172.
      View in: PubMed
    21. Bu W, Settembre EC, el Kouni MH, Ealick SE. Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines. Acta Crystallogr D Biol Crystallogr. 2005 Jul; 61(Pt 7):863-72. PMID: 15983408.
      View in: PubMed
    22. Rais RH, Al Safarjalani ON, Yadav V, Guarcello V, Kirk M, Chu CK, Naguib FN, el Kouni MH. 6-Benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities. Biochem Pharmacol. 2005 May 15; 69(10):1409-19. PMID: 15857605.
      View in: PubMed
    23. Al Safarjalani ON, Zhou XJ, Rais RH, Shi J, Schinazi RF, Naguib FN, El Kouni MH. 5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability: relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens. Cancer Chemother Pharmacol. 2005 Jun; 55(6):541-51. PMID: 15729584.
      View in: PubMed
    24. Yadav V, Chu CK, Rais RH, Al Safarjalani ON, Guarcello V, Naguib FN, el Kouni MH. Synthesis, biological activity and molecular modeling of 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase. J Med Chem. 2004 Apr 08; 47(8):1987-96. PMID: 15055998.
      View in: PubMed
    25. Al Safarjalani ON, Naguib FN, El Kouni MH. Uptake of nitrobenzylthioinosine and purine beta-L-nucleosides by intracellular Toxoplasma gondii. Antimicrob Agents Chemother. 2003 Oct; 47(10):3247-51. PMID: 14506037.
      View in: PubMed
    26. el Kouni MH. Potential chemotherapeutic targets in the purine metabolism of parasites. Pharmacol Ther. 2003 Sep; 99(3):283-309. PMID: 12951162.
      View in: PubMed
    27. el Kouni MH. Trends in the design of nucleoside analogues as anti-HIV drugs. Curr Pharm Des. 2002; 8(8):581-93. PMID: 11945160.
      View in: PubMed
    28. Song GY, Naguib FN, el Kouni MH, Chu CK. Synthesis of carbocyclic orotidine analogs as potential orotidine decarboxylase inhibitors. Nucleosides Nucleotides Nucleic Acids. 2001 Dec; 20(12):1915-25. PMID: 11794797.
      View in: PubMed
    29. Al Safarjalani ON, Zhou XJ, Naguib FN, Shi J, Schinazi RF, el Kouni MH. Enhancement of the bioavailability of oral uridine by coadministration of 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for uridine rescue regimens in chemotherapy. Cancer Chemother Pharmacol. 2001 Nov; 48(5):389-97. PMID: 11761457.
      View in: PubMed
    30. Al Safarjalani ON, Zhou XJ, Naguib FN, Goudgaon NM, Schinazi RF, el Kouni MH. Modulation of the pharmacokinetics of endogenous plasma uridine by 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for chemotherapy. Cancer Chemother Pharmacol. 2001 Aug; 48(2):145-50. PMID: 11565561.
      View in: PubMed
    31. Placidi L, Faraj A, Loi AG, Pierra C, Egron D, Cretton-Scott E, Gosseli G, Périgaud C, Martin LT, Schinazi RF, Imbach JL, el Kouni MH, Bryant ML, Sommadossi JP. Antiviral activity and intracellular metabolism of bis(tButylSATE) phosphotriester of beta-L-2',3'dideoxyadenosine, a potent inhibitor of HIV and HBV replication. Antivir Chem Chemother. 2001 Mar; 12(2):99-108. PMID: 11527047.
      View in: PubMed
    32. el Kouni MH, Goudgaon NM, Rafeeq M, Al Safarjalani ON, Schinazi RF, Naguib FN. 5-phenylthioacyclouridine: a potent and specific inhibitor of uridine phosphorylase. Biochem Pharmacol. 2000 Sep 15; 60(6):851-6. PMID: 10930540.
      View in: PubMed
    33. Ashour OM, Naguib FN, Goudgaon NM, Schinazi RF, el Kouni MH. Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2'-deoxyuridine against murine colon tumor C26-10. Biochem Pharmacol. 2000 Sep 01; 60(5):687-92. PMID: 10927027.
      View in: PubMed
    34. Ashour OM, Naguib FN, Panzica RP, Al Safarjalani ON, el Kouni MH. Modulation of 5-fluorouracil host toxicity by 5-(benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2',3',5'-tri-O-acetyluridine, a prodrug of uridine. Biochem Pharmacol. 2000 Aug 01; 60(3):427-31. PMID: 10856438.
      View in: PubMed
    35. Placidi L, Cretton-Scott E, Gosselin G, Pierra C, Schinazi RF, Imbach JL, el Kouni MH, Sommadossi JP. Intracellular metabolism of beta-L-2',3'-dideoxyadenosine: relevance to its limited antiviral activity. Antimicrob Agents Chemother. 2000 Apr; 44(4):853-8. PMID: 10722481.
      View in: PubMed
    36. Ashour OM, Naguib FN, Goudgaon NM, Schinazi RF, el Kouni MH. Effect of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on plasma concentration of uridine released from 2',3',5'-tri-O-acetyluridine, a prodrug of uridine: relevance to uridine rescue in chemotherapy. Cancer Chemother Pharmacol. 2000; 46(3):235-40. PMID: 11021741.
      View in: PubMed
    37. Ashour OM, Al Safarjalani ON, Naguib FN, Goudgaon NM, Schinazi RF, el Kouni MH. Modulation of plasma uridine concentration by 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase: relevance to chemotherapy. Cancer Chemother Pharmacol. 2000; 45(5):351-61. PMID: 10803917.
      View in: PubMed
    38. Chiang CW, Carter N, Sullivan WJ, Donald RG, Roos DS, Naguib FN, el Kouni MH, Ullman B, Wilson CM. The adenosine transporter of Toxoplasma gondii. Identification by insertional mutagenesis, cloning, and recombinant expression. J Biol Chem. 1999 Dec 03; 274(49):35255-61. PMID: 10575012.
      View in: PubMed
    39. Javaid ZZ, el Kouni MH, Iltzsch MH. Pyrimidine nucleobase ligands of orotate phosphoribosyltransferase from Toxoplasma gondii. Biochem Pharmacol. 1999 Nov 01; 58(9):1457-65. PMID: 10513989.
      View in: PubMed
    40. el Kouni MH, Guarcello V, Al Safarjalani ON, Naguib FN. Metabolism and selective toxicity of 6-nitrobenzylthioinosine in Toxoplasma gondii. Antimicrob Agents Chemother. 1999 Oct; 43(10):2437-43. PMID: 10508021.
      View in: PubMed
    41. Sullivan WJ, Chiang CW, Wilson CM, Naguib FN, el Kouni MH, Donald RG, Roos DS. Insertional tagging of at least two loci associated with resistance to adenine arabinoside in Toxoplasma gondii, and cloning of the adenosine kinase locus. Mol Biochem Parasitol. 1999 Sep 20; 103(1):1-14. PMID: 10514076.
      View in: PubMed
    42. Guerin DJ, Mazeas D, Musale MS, Naguib FN, Al Safarjalani ON, el Kouni MH, Panzica RP. Uridine phosphorylase inhibitors: chemical modification of benzyloxybenzyl-barbituric acid and its effects on urdpase inhibition. Bioorg Med Chem Lett. 1999 Jun 07; 9(11):1477-80. PMID: 10386920.
      View in: PubMed
    43. Ashour OM, Naguib FN, el Kouni MH. 5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2',3',5'-tri-O-acetyluridine, a prodrug of uridine, as modulators of plasma uridine concentration. Implications for chemotherapy. Biochem Pharmacol. 1996 Jun 28; 51(12):1601-11. PMID: 8687475.
      View in: PubMed
    44. el Kouni MH, Naguib FN, Panzica RP, Otter BA, Chu SH, Gosselin G, Chu CK, Schinazi RF, Shealy YF, Goudgaon N, Ozerov AA, Ueda T, Iltzsch MH. Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii. Biochem Pharmacol. 1996 Jun 28; 51(12):1687-700. PMID: 8687484.
      View in: PubMed
    45. Naguib FN, Iltzsch MH, el Kouni MM, Panzica RP, el Kouni MH. Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii. Biochem Pharmacol. 1995 Nov 09; 50(10):1685-93. PMID: 7503772.
      View in: PubMed
    46. Iltzsch MH, Uber SS, Tankersley KO, el Kouni MH. Structure-activity relationship for the binding of nucleoside ligands to adenosine kinase from Toxoplasma gondii. Biochem Pharmacol. 1995 May 17; 49(10):1501-12. PMID: 7763293.
      View in: PubMed
    47. Ashour OM, Naguib FN, Khalifa MM, Abdel-Raheem MH, Panzica RP, el Kouni MH. Enhancement of 5-fluoro-2'-deoxyuridine antitumor efficacy by the uridine phosphorylase inhibitor 5-(benzyloxybenzyl)barbituric acid acyclonucleoside. Cancer Res. 1995 Mar 01; 55(5):1092-8. PMID: 7866994.
      View in: PubMed
    48. Sommadossi JP, Cretton EM, Kidd LB, McClure HM, Anderson DC, el Kouni MH. Effects of 5-benzylacyclouridine, an inhibitor of uridine phosphorylase, on the pharmacokinetics of uridine in rhesus monkeys: implications for chemotherapy. Cancer Chemother Pharmacol. 1995; 37(1-2):14-22. PMID: 7497584.
      View in: PubMed
    49. Naguib FN, Hao SN, el Kouni MH. Potentiation of 5-fluorouracil efficacy by the dihydrouracil dehydrogenase inhibitor, 5-benzyloxybenzyluracil. Cancer Res. 1994 Oct 01; 54(19):5166-70. PMID: 7923135.
      View in: PubMed
    50. Goudgaon NM, Naguib FN, el Kouni MH, Schinazi RF. Phenylselenenyl- and phenylthio-substituted pyrimidines as inhibitors of dihydrouracil dehydrogenase and uridine phosphorylase. J Med Chem. 1993 Dec 24; 36(26):4250-4. PMID: 8277507.
      View in: PubMed
    51. Naguib FN, Levesque DL, Wang EC, Panzica RP, el Kouni MH. 5-Benzylbarbituric acid derivatives, potent and specific inhibitors of uridine phosphorylase. Biochem Pharmacol. 1993 Oct 05; 46(7):1273-83. PMID: 8216379.
      View in: PubMed
    52. el Kouni MH, el Kouni MM, Naguib FN. Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines. Cancer Res. 1993 Aug 15; 53(16):3687-93. PMID: 8339277.
      View in: PubMed
    53. Naguib FN, Soong SJ, el Kouni MH. Circadian rhythm of orotate phosphoribosyltransferase, pyrimidine nucleoside phosphorylases and dihydrouracil dehydrogenase in mouse liver. Possible relevance to chemotherapy with 5-fluoropyrimidines. Biochem Pharmacol. 1993 Feb 09; 45(3):667-73. PMID: 8442766.
      View in: PubMed
    54. el Kouni MH. Chemotherapy of schistosomiasis. R I Med. 1992 Apr; 75(4):212-6. PMID: 1600256.
      View in: PubMed
    55. Daher GC, Naguib FN, el Kouni MH, Zhang RW, Soong SJ, Diasio RB. Inhibition of fluoropyrimidine catabolism by benzyloxybenzyluracil. Possible relevance to regional chemotherapy. Biochem Pharmacol. 1991 Jun 15; 41(12):1887-93. PMID: 1828154.
      View in: PubMed
    56. el Kouni MH. Efficacy of combination therapy with tubercidin and nitrobenzylthioinosine 5'-monophosphate against chronic and advanced stages of schistosomiasis. Biochem Pharmacol. 1991 Mar 01; 41(5):815-20. PMID: 1900158.
      View in: PubMed
    57. el Kouni MH, Naguib FN, Park KS, Cha S, Darnowski JW, Soong SJ. Circadian rhythm of hepatic uridine phosphorylase activity and plasma concentration of uridine in mice. Biochem Pharmacol. 1990 Dec 01; 40(11):2479-85. PMID: 2148479.
      View in: PubMed
    58. el Kouni MH, Naguib FN. Pyrimidine salvage pathways in adult Schistosoma mansoni. Int J Parasitol. 1990 Feb; 20(1):37-44. PMID: 2312224.
      View in: PubMed
    59. el Kouni MH, Diop D, O'Shea P, Carlisle R, Sommadossi JP. Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis. Antimicrob Agents Chemother. 1989 Jun; 33(6):824-7. PMID: 2764531.
      View in: PubMed
    60. Naguib FN, el Kouni MH, Cha S. Structure-activity relationship of ligands of dihydrouracil dehydrogenase from mouse liver. Biochem Pharmacol. 1989 May 01; 38(9):1471-80. PMID: 2719721.
      View in: PubMed
    61. el Kouni MH, Naguib FN, Chu SH, Cha SM, Ueda T, Gosselin G, Imbach JL, Shealy YF, Otter BA. Effect of the N-glycosidic bond conformation and modifications in the pentose moiety on the binding of nucleoside ligands to uridine phosphorylase. Mol Pharmacol. 1988 Aug; 34(2):104-10. PMID: 3412318.
      View in: PubMed
    62. el Kouni MH, Naguib FN, Niedzwicki JG, Iltzsch MH, Cha S. Uridine phosphorylase from Schistosoma mansoni. J Biol Chem. 1988 May 05; 263(13):6081-6. PMID: 3360774.
      View in: PubMed
    63. el Kouni MH, Messier NJ, Cha S. Treatment of schistosomiasis by purine nucleoside analogues in combination with nucleoside transport inhibitors. Biochem Pharmacol. 1987 Nov 15; 36(22):3815-21. PMID: 3689423.
      View in: PubMed
    64. Naguib FN, el Kouni MH, Chu SH, Cha S. New analogues of benzylacyclouridines, specific and potent inhibitors of uridine phosphorylase from human and mouse livers. Biochem Pharmacol. 1987 Jul 01; 36(13):2195-201. PMID: 3606636.
      View in: PubMed
    65. el Kouni MH, Cha S. Metabolism of adenosine analogues by Schistosoma mansoni and the effect of nucleoside transport inhibitors. Biochem Pharmacol. 1987 Apr 01; 36(7):1099-106. PMID: 3566804.
      View in: PubMed
    66. Naguib FN, Niedzwicki JG, Iltzsch MH, Wiemann MC, el Kouni MH, Cha SM. Effects of N,N-dimethylformamide and sodium butyrate on enzymes of pyrimidine metabolism in cultured human tumor cells. Leuk Res. 1987; 11(10):855-61. PMID: 3682865.
      View in: PubMed
    67. Park KS, el Kouni MH, Krenitsky TA, Chu SH, Cha S. Inhibition of uridine phosphorylase from Escherichia coli by benzylacyclouridines. Biochem Pharmacol. 1986 Nov 01; 35(21):3853-5. PMID: 3535805.
      View in: PubMed
    68. Iltzsch MH, el Kouni MH, Cha S. Kinetic studies of thymidine phosphorylase from mouse liver. Biochemistry. 1985 Nov 19; 24(24):6799-807. PMID: 4074727.
      View in: PubMed
    69. el Kouni MH, Knopf PM, Cha SM. Combination therapy of Schistosoma japonicum by tubercidin and nitrobenzylthioinosine 5'-monophosphate. Biochem Pharmacol. 1985 Nov 01; 34(21):3921-3. PMID: 3933515.
      View in: PubMed
    70. Naguib FN, el Kouni MH, Cha S. Enzymes of uracil catabolism in normal and neoplastic human tissues. Cancer Res. 1985 Nov; 45(11 Pt 1):5405-12. PMID: 3931905.
      View in: PubMed
    71. Burgess FW, el Kouni MH, Parks RE. Nucleotidase activities of human peripheral lymphocytes. Biochem Pharmacol. 1985 Sep 01; 34(17):3061-70. PMID: 2994675.
      View in: PubMed
    72. Lee KH, el Kouni MH, Chu HS, Cha S. Inhibition of nucleoside transport in murine lymphoma L5178Y cells and human erythrocytes by the uridine phosphorylase inhibitors 5-benzylacyclouridine and 5-benzyloxybenzylacyclouridine. Cancer Res. 1984 Sep; 44(9):3744-8. PMID: 6744292.
      View in: PubMed
    73. Niedzwicki JG, Iltzsch MH, el Kouni MH, Cha S. Structure-activity relationship of pyrimidine base analogs as ligands of orotate phosphoribosyltransferase. Biochem Pharmacol. 1984 Aug 01; 33(15):2383-95. PMID: 6466360.
      View in: PubMed
    74. Iltzsch MH, Niedzwicki JG, Senft AW, Cha S, El Kouni MH. Enzymes of uridine 5'-monophosphate biosynthesis in Schistosoma mansoni. Mol Biochem Parasitol. 1984 Jun; 12(2):153-71. PMID: 6090897.
      View in: PubMed
    75. Chu MY, Naguib FN, Iltzsch MH, el Kouni MH, Chu SH, Cha S, Calabresi P. Potentiation of 5-fluoro-2'-deoxyuridine antineoplastic activity by the uridine phosphorylase inhibitors benzylacyclouridine and benzyloxybenzylacyclouridine. Cancer Res. 1984 May; 44(5):1852-6. PMID: 6231986.
      View in: PubMed
    76. el Kouni MH, Diop D, Cha S. Combination therapy of schistosomiasis by tubercidin and nitrobenzylthioinosine 5'-monophosphate. Proc Natl Acad Sci U S A. 1983 Nov; 80(21):6667-70. PMID: 6579551.
      View in: PubMed
    77. Niedzwicki JG, el Kouni MH, Chu SH, Cha S. Structure-activity relationship of ligands of the pyrimidine nucleoside phosphorylases. Biochem Pharmacol. 1983 Feb 01; 32(3):399-415. PMID: 6847695.
      View in: PubMed
    78. Niedzwicki JG, Chu SH, el Kouni MH, Rowe EC, Cha S. 5-benzylacyclouridine and 5-benzyloxybenzylacyclouridine, potent inhibitors of uridine phosphorylase. Biochem Pharmacol. 1982 May 15; 31(10):1857-61. PMID: 7104017.
      View in: PubMed
    79. El Kouni MH, Cha S. Isolation and partial characterization of a 5'-nucleotidase specific for orotidine-5'-monophosphate. Proc Natl Acad Sci U S A. 1982 Feb; 79(4):1037-41. PMID: 6280163.
      View in: PubMed
    80. Niedzwicki JG, el Kouni MH, Chu SH, Cha S. Pyrimidine acyclonucleosides, inhibitors of uridine phosphorylase. Biochem Pharmacol. 1981 Aug 01; 30(15):2097-101. PMID: 7295329.
      View in: PubMed
    81. el Kouni MH, Cha S. A simple radioisotopic assay for nucleoside kinases employing alumina for separation of nucleosides and nucleotides. Anal Biochem. 1981 Feb; 111(1):67-71. PMID: 6263130.
      View in: PubMed
    82. el Kouni MH, Nash D. Survival of Drosophila melanogaster larvae on defined medium supplemented with naturally occurring nucleosides and nucleic acid bases. J Insect Physiol. 1977; 23(3):327-31. PMID: 407308.
      View in: PubMed
    83. el Kouni MH, Nash D. Biology of 5-fluoro-2'-deoxyuridine sensitivity of Drosophila melanogaster larvae. J Insect Physiol. 1974 Aug; 20(8):1481-90. PMID: 4277380.
      View in: PubMed
    El Kouni's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _