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Professor Kenneth Cornell

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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cornell KA, Knippel RJ, Cortright GR, Fonken M, Guerrero C, Hall AR, Mitchell KA, Thurston JH, Erstad P, Tao A, Xu D, Parveen N. Characterization of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases from Borrelia burgdorferi: Antibiotic targets for Lyme disease. Biochim Biophys Acta Gen Subj. 2020 Jan; 1864(1):129455. PMID: 31669585.
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    2. Thurston JH, Hunter NM, Wayment LJ, Cornell KA. Urea-derived graphitic carbon nitride (u-g-C3N4) films with highly enhanced antimicrobial and sporicidal activity. J Colloid Interface Sci. 2017 Nov 01; 505:910-918. PMID: 28675870.
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    3. Lamb CL, Cholico GN, Pu X, Hagler GD, Cornell KA, Mitchell KA. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) increases necroinflammation and hepatic stellate cell activation but does not exacerbate experimental liver fibrosis in mice. Toxicol Appl Pharmacol. 2016 Nov 15; 311:42-51. PMID: 27693115.
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    4. Thurston JH, Hunter NM, Cornell KA. Preparation and characterization of photoactive antimicrobial graphitic carbon nitride (g-C3N4) films. RSC Adv. 2016; 6(48):42240-42248. PMID: 27672437.
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    5. Harvey WA, Jurgensen K, Pu X, Lamb CL, Cornell KA, Clark RJ, Klocke C, Mitchell KA. Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases human hepatic stellate cell activation. Toxicology. 2016 Feb 17; 344-346:26-33. PMID: 26860701.
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    6. Mallory CM, Carfi RP, Moon S, Cornell KA, Warner DL. Modification of cellular DNA by synthetic aziridinomitosenes. Bioorg Med Chem. 2015 Dec 01; 23(23):7378-85. PMID: 26541587.
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    7. Tinker JK, Yan J, Knippel RJ, Panayiotou P, Cornell KA. Immunogenicity of a West Nile virus DIII-cholera toxin A2/B chimera after intranasal delivery. Toxins (Basel). 2014 Apr 22; 6(4):1397-418. PMID: 24759174.
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    8. Parveen N, Cornell KA. Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism. Mol Microbiol. 2011 Jan; 79(1):7-20. PMID: 21166890.
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    9. Turner M, Eidemiller S, Martin B, Narver A, Marshall J, Zemp L, Cornell KA, McIntosh JM, McDougal OM. Structural basis for alpha-conotoxin potency and selectivity. Bioorg Med Chem. 2009 Aug 15; 17(16):5894-9. PMID: 19628399.
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    10. Cornell KA, Primus S, Martinez JA, Parveen N. Assessment of methylthioadenosine/S-adenosylhomocysteine nucleosidases of Borrelia burgdorferi as targets for novel antimicrobials using a novel high-throughput method. J Antimicrob Chemother. 2009 Jun; 63(6):1163-72. PMID: 19376840.
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    11. Siu KK, Lee JE, Sufrin JR, Moffatt BA, McMillan M, Cornell KA, Isom C, Howell PL. Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases. J Mol Biol. 2008 Apr 18; 378(1):112-28. PMID: 18342331.
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    12. Ku SY, Cornell KA, Howell PL. Structure of Arabidopsis thaliana 5-methylthioribose kinase reveals a more occluded active site than its bacterial homolog. BMC Struct Biol. 2007 Oct 25; 7:70. PMID: 17961230.
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    13. Ku SY, Yip P, Cornell KA, Riscoe MK, Behr JB, Guillerm G, Howell PL. Structures of 5-methylthioribose kinase reveal substrate specificity and unusual mode of nucleotide binding. J Biol Chem. 2007 Jul 27; 282(30):22195-206. PMID: 17522047.
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    14. Rzewuski G, Cornell KA, Rooney L, Bürstenbinder K, Wirtz M, Hell R, Sauter M. OsMTN encodes a 5'-methylthioadenosine nucleosidase that is up-regulated during submergence-induced ethylene synthesis in rice (Oryza sativa L.). J Exp Bot. 2007; 58(6):1505-14. PMID: 17339651.
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    15. Parveen N, Cornell KA, Bono JL, Chamberland C, Rosa P, Leong JM. Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice. Infect Immun. 2006 May; 74(5):3016-20. PMID: 16622242.
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    16. Lee JE, Smith GD, Horvatin C, Huang DJ, Cornell KA, Riscoe MK, Howell PL. Structural snapshots of MTA/AdoHcy nucleosidase along the reaction coordinate provide insights into enzyme and nucleoside flexibility during catalysis. J Mol Biol. 2005 Sep 23; 352(3):559-74. PMID: 16109423.
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    17. Lee JE, Luong W, Huang DJ, Cornell KA, Riscoe MK, Howell PL. Mutational analysis of a nucleosidase involved in quorum-sensing autoinducer-2 biosynthesis. Biochemistry. 2005 Aug 23; 44(33):11049-57. PMID: 16101288.
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    18. Lee JE, Singh V, Evans GB, Tyler PC, Furneaux RH, Cornell KA, Riscoe MK, Schramm VL, Howell PL. Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. J Biol Chem. 2005 May 06; 280(18):18274-82. PMID: 15746096.
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    19. Sauter M, Cornell KA, Beszteri S, Rzewuski G. Functional analysis of methylthioribose kinase genes in plants. Plant Physiol. 2004 Dec; 136(4):4061-71. PMID: 15557090.
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    20. Cook PW, Brown JR, Cornell KA, Pittelkow MR. Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis. Exp Dermatol. 2004 Jun; 13(6):347-56. PMID: 15186320.
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    21. Lee JE, Settembre EC, Cornell KA, Riscoe MK, Sufrin JR, Ealick SE, Howell PL. Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design. Biochemistry. 2004 May 11; 43(18):5159-69. PMID: 15122881.
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    22. Ku SY, Yip P, Cornell KA, Riscoe MK, Howell PL. Crystallization and preliminary X-ray analysis of 5'-methylthioribose kinase from Bacillus subtilis and Arabidopsis thaliana. Acta Crystallogr D Biol Crystallogr. 2004 Jan; 60(Pt 1):116-9. PMID: 14684902.
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    23. Zhao G, Wan W, Mansouri S, Alfaro JF, Bassler BL, Cornell KA, Zhou ZS. Chemical synthesis of S-ribosyl-L-homocysteine and activity assay as a LuxS substrate. Bioorg Med Chem Lett. 2003 Nov 17; 13(22):3897-900. PMID: 14592470.
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    24. Simon BE, Cornell KA, Clark TR, Chou S, Rosen HR, Barry RA. DNA vaccination protects mice against challenge with Listeria monocytogenes expressing the hepatitis C virus NS3 protein. Infect Immun. 2003 Nov; 71(11):6372-80. PMID: 14573658.
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    25. Barry RA, Archie Bouwer HG, Clark TR, Cornell KA, Hinrichs DJ. Protection of interferon-gamma knockout mice against Listeria monocytogenes challenge following intramuscular immunization with DNA vaccines encoding listeriolysin O. Vaccine. 2003 May 16; 21(17-18):2122-32. PMID: 12706703.
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    26. Lee JE, Cornell KA, Riscoe MK, Howell PL. Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis. J Biol Chem. 2003 Mar 07; 278(10):8761-70. PMID: 12496243.
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    27. Winzer K, Hardie KR, Burgess N, Doherty N, Kirke D, Holden MTG, Linforth R, Cornell KA, Taylor AJ, Hill PJ, Williams P. LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H)-furanone. Microbiology. 2002 Apr; 148(Pt 4):909-922. PMID: 11932438.
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    28. Lee JE, Cornell KA, Riscoe MK, Howell PL. Structure of E. coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase reveals similarity to the purine nucleoside phosphorylases. Structure. 2001 Oct; 9(10):941-53. PMID: 11591349.
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    29. Lee JE, Cornell KA, Riscoe MK, Howell PL. Expression, purification, crystallization and preliminary X-ray analysis of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. Acta Crystallogr D Biol Crystallogr. 2001 Jan; 57(Pt 1):150-2. PMID: 11134941.
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    30. Brown JR, Cornell K, Cook PW. Adenosine- and adenine-nucleotide-mediated inhibition of normal and transformed keratinocyte proliferation is dependent upon dipyridamole-sensitive adenosine transport. J Invest Dermatol. 2000 Nov; 115(5):849-59. PMID: 11069623.
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    31. Cornell KA, Bouwer HG, Hinrichs DJ, Barry RA. Genetic immunization of mice against Listeria monocytogenes using plasmid DNA encoding listeriolysin O. J Immunol. 1999 Jul 01; 163(1):322-9. PMID: 10384131.
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    32. Cornell KA, Riscoe MK. Cloning and expression of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase: identification of the pfs gene product. Biochim Biophys Acta. 1998 Mar 04; 1396(1):8-14. PMID: 9524204.
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    33. Winter RW, Ignatushchenko M, Ogundahunsi OA, Cornell KA, Oduola AM, Hinrichs DJ, Riscoe MK. Potentiation of an antimalarial oxidant drug. Antimicrob Agents Chemother. 1997 Jul; 41(7):1449-54. PMID: 9210664.
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    34. Cornell KA, Swarts WE, Barry RD, Riscoe MK. Characterization of recombinant Eschericha coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase: analysis of enzymatic activity and substrate specificity. Biochem Biophys Res Commun. 1996 Nov 21; 228(3):724-32. PMID: 8941345.
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    35. Cornell KA, Winter RW, Tower PA, Riscoe MK. Affinity purification of 5-methylthioribose kinase and 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Klebsiella pneumoniae [corrected]. Biochem J. 1996 Jul 01; 317 ( Pt 1):285-90. PMID: 8694776.
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    36. Winter RW, Cornell KA, Johnson LL, Ignatushchenko M, Hinrichs DJ, Riscoe MK. Potentiation of the antimalarial agent rufigallol. Antimicrob Agents Chemother. 1996 Jun; 40(6):1408-11. PMID: 8726010.
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    37. Hefeneider SH, Brown LE, McCoy SL, Bakke AC, Cornell KA, Bennett RM. Immunization of BALB/c mice with a monoclonal anti-DNA antibody induces an anti-idiotypic antibody reactive with a cell-surface DNA binding protein. Autoimmunity. 1993; 15(3):187-94. PMID: 8268397.
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    38. Bennett RM, Cornell KA, Merritt MJ, Bakke AC, Mourich D, Hefeneider SH. Idiotypic mimicry of a cell surface DNA receptor: evidence for anti-DNA antibodies being a subset of anti-anti-DNA receptor antibodies. Clin Exp Immunol. 1992 Dec; 90(3):428-33. PMID: 1333925.
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    39. Hefeneider SH, Cornell KA, Brown LE, Bakke AC, McCoy SL, Bennett RM. Nucleosomes and DNA bind to specific cell-surface molecules on murine cells and induce cytokine production. Clin Immunol Immunopathol. 1992 Jun; 63(3):245-51. PMID: 1623645.
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    40. Hefeneider SH, McCoy SL, Morton JI, Bakke AC, Cornell KA, Brown LE, Bennett RM. DNA binding to mouse cells is mediated by cell-surface molecules: the role of these DNA-binding molecules as target antigens in murine lupus. Lupus. 1992 May; 1(3):167-73. PMID: 1301977.
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    41. Bennett RM, Cornell KA, Merritt MJ, Bakke AC, Hsu PH, Hefeneider SH. Autoimmunity to a 28-30 kD cell membrane DNA binding protein: occurrence in selected sera from patients with SLE and mixed connective tissue disease (MCTD). Clin Exp Immunol. 1991 Dec; 86(3):374-9. PMID: 1747945.
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    42. Hefeneider SH, Bennett RM, Pham TQ, Cornell K, McCoy SL, Heinrich MC. Identification of a cell-surface DNA receptor and its association with systemic lupus erythematosus. J Invest Dermatol. 1990 Jun; 94(6 Suppl):79S-84S. PMID: 2161889.
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