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Professor Frederik Richard Opperdoes

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kraeva N, Butenko A, Hlavácová J, Kostygov A, Myškova J, Grybchuk D, Leštinová T, Votýpka J, Volf P, Opperdoes F, Flegontov P, Lukeš J, Yurchenko V. Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania donovani. PLoS Pathog. 2015 Aug; 11(8):e1005127. PMID: 26317207; PMCID: PMC4552786.
    2. Shameer S, Logan-Klumpler FJ, Vinson F, Cottret L, Merlet B, Achcar F, Boshart M, Berriman M, Breitling R, Bringaud F, Bütikofer P, Cattanach AM, Bannerman-Chukualim B, Creek DJ, Crouch K, de Koning HP, Denise H, Ebikeme C, Fairlamb AH, Ferguson MA, Ginger ML, Hertz-Fowler C, Kerkhoven EJ, Mäser P, Michels PA, Nayak A, Nes DW, Nolan DP, Olsen C, Silva-Franco F, Smith TK, Taylor MC, Tielens AG, Urbaniak MD, van Hellemond JJ, Vincent IM, Wilkinson SR, Wyllie S, Opperdoes FR, Barrett MP, Jourdan F. TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Res. 2015 Jan; 43(Database issue):D637-44. PMID: 25300491; PMCID: PMC4384016.
    3. Studer RA, Opperdoes FR, Nicolaes GA, Mulder AB, Mulder R. Understanding the functional difference between growth arrest-specific protein 6 and protein S: an evolutionary approach. Open Biol. 2014 Oct; 4(10). PMID: 25339693; PMCID: PMC4221892.
    4. Porcel BM, Denoeud F, Opperdoes F, Noel B, Madoui MA, Hammarton TC, Field MC, Da Silva C, Couloux A, Poulain J, Katinka M, Jabbari K, Aury JM, Campbell DA, Cintron R, Dickens NJ, Docampo R, Sturm NR, Koumandou VL, Fabre S, Flegontov P, Lukeš J, Michaeli S, Mottram JC, Szöor B, Zilberstein D, Bringaud F, Wincker P, Dollet M. The streamlined genome of Phytomonas spp. relative to human pathogenic kinetoplastids reveals a parasite tailored for plants. PLoS Genet. 2014 Feb; 10(2):e1004007. PMID: 24516393; PMCID: PMC3916237.
    5. Berg M, Vanaerschot M, Jankevics A, Cuypers B, Maes I, Mukherjee S, Khanal B, Rijal S, Roy S, Opperdoes F, Breitling R, Dujardin JC. Metabolic adaptations of Leishmania donovani in relation to differentiation, drug resistance, and drug pressure. Mol Microbiol. 2013 Oct; 90(2):428-42. PMID: 24020363.
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    6. Opperdoes FR, De Jonckheere JF, Tielens AG. Naegleria gruberi metabolism. Int J Parasitol. 2011 Aug 01; 41(9):915-24. PMID: 21722646.
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    7. Leroux AE, Maugeri DA, Opperdoes FR, Cazzulo JJ, Nowicki C. Comparative studies on the biochemical properties of the malic enzymes from Trypanosoma cruzi and Trypanosoma brucei. FEMS Microbiol Lett. 2011 Jan; 314(1):25-33. PMID: 21105905.
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    8. De Jonckheere JF, Baumgartner M, Eberhardt S, Opperdoes FR, Stetter KO. Oramoeba fumarolia gen. nov., sp. nov., a new marine heterolobosean amoeboflagellate growing at 54 °C. Eur J Protistol. 2011 Jan; 47(1):16-23. PMID: 20932726.
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    9. Collard F, Stroobant V, Lamosa P, Kapanda CN, Lambert DM, Muccioli GG, Poupaert JH, Opperdoes F, Van Schaftingen E. Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase. J Biol Chem. 2010 Sep 24; 285(39):29826-33. PMID: 20657015; PMCID: PMC2943312.
    10. Veiga-da-Cunha M, Tyteca D, Stroobant V, Courtoy PJ, Opperdoes FR, Van Schaftingen E. Molecular identification of NAT8 as the enzyme that acetylates cysteine S-conjugates to mercapturic acids. J Biol Chem. 2010 Jun 11; 285(24):18888-98. PMID: 20392701; PMCID: PMC2881811.
    11. Veiga-da-Cunha M, Sokolova T, Opperdoes F, Van Schaftingen E. Evolution of vertebrate glucokinase regulatory protein from a bacterial N-acetylmuramate 6-phosphate etherase. Biochem J. 2009 Oct 12; 423(3):323-32. PMID: 19671048.
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    12. De Jonckheere JF, Baumgartner M, Opperdoes FR, Stetter KO. Marinamoeba thermophila, a new marine heterolobosean amoeba growing at 50 degrees C. Eur J Protistol. 2009 Aug; 45(3):231-6. PMID: 19339165.
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    13. Opperdoes FR, Michels PA. Complex I of Trypanosomatidae: does it exist? Trends Parasitol. 2008 Jul; 24(7):310-7. PMID: 18534909.
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    14. Marciano D, Llorente C, Maugeri DA, de la Fuente C, Opperdoes F, Cazzulo JJ, Nowicki C. Biochemical characterization of stage-specific isoforms of aspartate aminotransferases from Trypanosoma cruzi and Trypanosoma brucei. Mol Biochem Parasitol. 2008 Sep; 161(1):12-20. PMID: 18602174.
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    15. Vertommen D, Van Roy J, Szikora JP, Rider MH, Michels PA, Opperdoes FR. Differential expression of glycosomal and mitochondrial proteins in the two major life-cycle stages of Trypanosoma brucei. Mol Biochem Parasitol. 2008 Apr; 158(2):189-201. PMID: 18242729.
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    16. Rosenzweig D, Smith D, Opperdoes F, Stern S, Olafson RW, Zilberstein D. Retooling Leishmania metabolism: from sand fly gut to human macrophage. FASEB J. 2008 Feb; 22(2):590-602. PMID: 17884972.
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    17. Opperdoes FR, Michels PA. Horizontal gene transfer in trypanosomatids. Trends Parasitol. 2007 Oct; 23(10):470-6. PMID: 17826337.
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    18. Hoet S, Pieters L, Muccioli GG, Habib-Jiwan JL, Opperdoes FR, Quetin-Leclercq J. Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds. J Nat Prod. 2007 Aug; 70(8):1360-3. PMID: 17637068.
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    19. Opperdoes FR, Coombs GH. Metabolism of Leishmania: proven and predicted. Trends Parasitol. 2007 Apr; 23(4):149-58. PMID: 17320480.
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    20. Opperdoes FR, Szikora JP. In silico prediction of the glycosomal enzymes of Leishmania major and trypanosomes. Mol Biochem Parasitol. 2006 Jun; 147(2):193-206. PMID: 16546274.
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    21. van Hellemond JJ, Opperdoes FR, Tielens AG. The extraordinary mitochondrion and unusual citric acid cycle in Trypanosoma brucei. Biochem Soc Trans. 2005 Nov; 33(Pt 5):967-71. PMID: 16246022.
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    22. Aranda A, Maugeri D, Uttaro AD, Opperdoes F, Cazzulo JJ, Nowicki C. The malate dehydrogenase isoforms from Trypanosoma brucei: subcellular localization and differential expression in bloodstream and procyclic forms. Int J Parasitol. 2006 Mar; 36(3):295-307. PMID: 16321390.
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    23. Dufernez F, Yernaux C, Gerbod D, Noël C, Chauvenet M, Wintjens R, Edgcomb VP, Capron M, Opperdoes FR, Viscogliosi E. The presence of four iron-containing superoxide dismutase isozymes in trypanosomatidae: characterization, subcellular localization, and phylogenetic origin in Trypanosoma brucei. Free Radic Biol Med. 2006 Jan 15; 40(2):210-25. PMID: 16413404.
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    24. Atwood JA, Weatherly DB, Minning TA, Bundy B, Cavola C, Opperdoes FR, Orlando R, Tarleton RL. The Trypanosoma cruzi proteome. Science. 2005 Jul 15; 309(5733):473-6. PMID: 16020736.
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    25. Berriman M, Ghedin E, Hertz-Fowler C, Blandin G, Renauld H, Bartholomeu DC, Lennard NJ, Caler E, Hamlin NE, Haas B, Böhme U, Hannick L, Aslett MA, Shallom J, Marcello L, Hou L, Wickstead B, Alsmark UC, Arrowsmith C, Atkin RJ, Barron AJ, Bringaud F, Brooks K, Carrington M, Cherevach I, Chillingworth TJ, Churcher C, Clark LN, Corton CH, Cronin A, Davies RM, Doggett J, Djikeng A, Feldblyum T, Field MC, Fraser A, Goodhead I, Hance Z, Harper D, Harris BR, Hauser H, Hostetler J, Ivens A, Jagels K, Johnson D, Johnson J, Jones K, Kerhornou AX, Koo H, Larke N, Landfear S, Larkin C, Leech V, Line A, Lord A, Macleod A, Mooney PJ, Moule S, Martin DM, Morgan GW, Mungall K, Norbertczak H, Ormond D, Pai G, Peacock CS, Peterson J, Quail MA, Rabbinowitsch E, Rajandream MA, Reitter C, Salzberg SL, Sanders M, Schobel S, Sharp S, Simmonds M, Simpson AJ, Tallon L, Turner CM, Tait A, Tivey AR, Van Aken S, Walker D, Wanless D, Wang S, White B, White O, Whitehead S, Woodward J, Wortman J, Adams MD, Embley TM, Gull K, Ullu E, Barry JD, Fairlamb AH, Opperdoes F, Barrell BG, Donelson JE, Hall N, Fraser CM, Melville SE, El-Sayed NM. The genome of the African trypanosome Trypanosoma brucei. Science. 2005 Jul 15; 309(5733):416-22. PMID: 16020726.
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    26. Chevalier N, Bertrand L, Rider MH, Opperdoes FR, Rigden DJ, Michels PA. 6-Phosphofructo-2-kinase and fructose-2,6-bisphosphatase in Trypanosomatidae. Molecular characterization, database searches, modelling studies and evolutionary analysis. FEBS J. 2005 Jul; 272(14):3542-60. PMID: 16008555.
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    27. Albert MA, Haanstra JR, Hannaert V, Van Roy J, Opperdoes FR, Bakker BM, Michels PA. Experimental and in silico analyses of glycolytic flux control in bloodstream form Trypanosoma brucei. J Biol Chem. 2005 Aug 05; 280(31):28306-15. PMID: 15955817.
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    28. van Weelden SW, van Hellemond JJ, Opperdoes FR, Tielens AG. New functions for parts of the Krebs cycle in procyclic Trypanosoma brucei, a cycle not operating as a cycle. J Biol Chem. 2005 Apr 01; 280(13):12451-60. PMID: 15647263.
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    29. Delplanque J, Delpierre G, Opperdoes FR, Van Schaftingen E. Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein. J Biol Chem. 2004 Nov 05; 279(45):46606-13. PMID: 15331600.
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    30. Hoet S, Opperdoes F, Brun R, Quetin-Leclercq J. Natural products active against African trypanosomes: a step towards new drugs. Nat Prod Rep. 2004 Jun; 21(3):353-64. PMID: 15162223.
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    31. Guerra DG, Vertommen D, Fothergill-Gilmore LA, Opperdoes FR, Michels PA. Characterization of the cofactor-independent phosphoglycerate mutase from Leishmania mexicana mexicana. Histidines that coordinate the two metal ions in the active site show different susceptibilities to irreversible chemical modification. Eur J Biochem. 2004 May; 271(9):1798-810. PMID: 15096219.
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    32. Hoet S, Stévigny C, Block S, Opperdoes F, Colson P, Baldeyrou B, Lansiaux A, Bailly C, Quetin-Leclercq J. Alkaloids from Cassytha filiformis and related aporphines: antitrypanosomal activity, cytotoxicity, and interaction with DNA and topoisomerases. Planta Med. 2004 May; 70(5):407-13. PMID: 15124084.
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    33. Hoet S, Opperdoes F, Brun R, Adjakidjé V, Quetin-Leclercq J. In vitro antitrypanosomal activity of ethnopharmacologically selected Beninese plants. J Ethnopharmacol. 2004 Mar; 91(1):37-42. PMID: 15036465.
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    34. Azema L, Claustre S, Alric I, Blonski C, Willson M, Perié J, Baltz T, Tetaud E, Bringaud F, Cottem D, Opperdoes FR, Barrett MP. Interaction of substituted hexose analogues with the Trypanosoma brucei hexose transporter. Biochem Pharmacol. 2004 Feb 01; 67(3):459-67. PMID: 15037198.
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    35. Hannaert V, Albert MA, Rigden DJ, da Silva Giotto MT, Thiemann O, Garratt RC, Van Roy J, Opperdoes FR, Michels PA. Kinetic characterization, structure modelling studies and crystallization of Trypanosoma brucei enolase. Eur J Biochem. 2003 Aug; 270(15):3205-13. PMID: 12869196.
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    36. Molinas SM, Altabe SG, Opperdoes FR, Rider MH, Michels PA, Uttaro AD. The multifunctional isopropyl alcohol dehydrogenase of Phytomonas sp. could be the result of a horizontal gene transfer from a bacterium to the trypanosomatid lineage. J Biol Chem. 2003 Sep 19; 278(38):36169-75. PMID: 12853449.
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    37. Hannaert V, Saavedra E, Duffieux F, Szikora JP, Rigden DJ, Michels PA, Opperdoes FR. Plant-like traits associated with metabolism of Trypanosoma parasites. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1067-71. PMID: 12552132; PMCID: PMC298727.
    38. Foultier B, Troisfontaines P, Müller S, Opperdoes FR, Cornelis GR. Characterization of the ysa pathogenicity locus in the chromosome of Yersinia enterocolitica and phylogeny analysis of type III secretion systems. J Mol Evol. 2002 Jul; 55(1):37-51. PMID: 12165841.
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    39. Willson M, Sanejouand YH, Perie J, Hannaert V, Opperdoes F. Sequencing, modeling, and selective inhibition of Trypanosoma brucei hexokinase. Chem Biol. 2002 Jul; 9(7):839-47. PMID: 12144928.
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    40. Hannaert V, Yernaux C, Rigden DJ, Fothergill-Gilmore LA, Opperdoes FR, Michels PA. The putative effector-binding site of Leishmania mexicana pyruvate kinase studied by site-directed mutagenesis. FEBS Lett. 2002 Mar 13; 514(2-3):255-9. PMID: 11943161.
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    41. Miclet E, Stoven V, Michels PA, Opperdoes FR, Lallemand JY, Duffieux F. NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase. J Biol Chem. 2001 Sep 14; 276(37):34840-6. PMID: 11457850.
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    42. Opperdoes FR, Michels PA. Enzymes of carbohydrate metabolism as potential drug targets. Int J Parasitol. 2001 May 01; 31(5-6):482-90. PMID: 11334933.
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    43. Verlinde CL, Hannaert V, Blonski C, Willson M, Périé JJ, Fothergill-Gilmore LA, Opperdoes FR, Gelb MH, Hol WG, Michels PA. Glycolysis as a target for the design of new anti-trypanosome drugs. Drug Resist Updat. 2001 Feb; 4(1):50-65. PMID: 11512153.
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    44. Lux H, Heise N, Klenner T, Hart D, Opperdoes FR. Ether--lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether--lipid analogues in Leishmania. Mol Biochem Parasitol. 2000 Nov; 111(1):1-14. PMID: 11087912.
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    45. Uttaro AD, Altabe SG, Rider MH, Michels PA, Opperdoes FR. A family of highly conserved glycosomal 2-hydroxyacid dehydrogenases from Phytomonas sp. J Biol Chem. 2000 Oct 13; 275(41):31833-7. PMID: 10900211.
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    46. Duffieux F, Van Roy J, Michels PA, Opperdoes FR. Molecular characterization of the first two enzymes of the pentose-phosphate pathway of Trypanosoma brucei. Glucose-6-phosphate dehydrogenase and 6-phosphogluconolactonase. J Biol Chem. 2000 Sep 08; 275(36):27559-65. PMID: 10867008.
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    47. Suresh S, Turley S, Opperdoes FR, Michels PA, Hol WG. A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana. Structure. 2000 May 15; 8(5):541-52. PMID: 10801498.
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    48. Heise N, Opperdoes FR. Localisation of a 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the mitochondrial matrix of Trypanosoma brucei procyclics. Z Naturforsch C. 2000 May-Jun; 55(5-6):473-7. PMID: 10928562.
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    49. Králová I, Rigden DJ, Opperdoes FR, Michels PA. Glycerol kinase of Trypanosoma brucei. Cloning, molecular characterization and mutagenesis. Eur J Biochem. 2000 Apr; 267(8):2323-33. PMID: 10759857.
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    50. Chevalier N, Rigden DJ, Van Roy J, Opperdoes FR, Michels PA. Trypanosoma brucei contains a 2,3-bisphosphoglycerate independent phosphoglycerate mutase. Eur J Biochem. 2000 Mar; 267(5):1464-72. PMID: 10691985.
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    51. Bakker BM, Westerhoff HV, Opperdoes FR, Michels PA. Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs. Mol Biochem Parasitol. 2000 Feb 25; 106(1):1-10. PMID: 10743606.
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    52. Marché S, Michels PA, Opperdoes FR. Comparative study of Leishmania mexicana and Trypanosoma brucei NAD-dependent glycerol-3-phosphate dehydrogenase. Mol Biochem Parasitol. 2000 Feb 25; 106(1):83-91. PMID: 10743613.
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    53. Hardré R, Salmon L, Opperdoes FR. Competitive inhibition of Trypanosoma brucei phosphoglucose isomerase by D-arabinose-5-phosphate derivatives. J Enzyme Inhib. 2000; 15(5):509-15. PMID: 11030090.
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    54. Zomer AW, Michels PA, Opperdoes FR. Molecular characterisation of Trypanosoma brucei alkyl dihydroxyacetone-phosphate synthase. Mol Biochem Parasitol. 1999 Oct 25; 104(1):55-66. PMID: 10589981.
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    55. de Walque S, Kiel JA, Veenhuis M, Opperdoes FR, Michels PA. Cloning and analysis of the PTS-1 receptor in Trypanosoma brucei. Mol Biochem Parasitol. 1999 Oct 25; 104(1):106-19. PMID: 10589985.
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    56. de Walque S, Opperdoes FR, Michels PA. Cloning and characterization of Leishmania mexicana fructose-1,6-bisphosphate aldolase. Mol Biochem Parasitol. 1999 Oct 15; 103(2):279-83. PMID: 10551371.
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    57. Bakker BM, Walsh MC, ter Kuile BH, Mensonides FI, Michels PA, Opperdoes FR, Westerhoff HV. Contribution of glucose transport to the control of the glycolytic flux in Trypanosoma brucei. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10098-103. PMID: 10468568; PMCID: PMC17848.
    58. Bakker BM, Michels PA, Opperdoes FR, Westerhoff HV. What controls glycolysis in bloodstream form Trypanosoma brucei? J Biol Chem. 1999 May 21; 274(21):14551-9. PMID: 10329645.
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    59. Aronov AM, Suresh S, Buckner FS, Van Voorhis WC, Verlinde CL, Opperdoes FR, Hol WG, Gelb MH. Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase. Proc Natl Acad Sci U S A. 1999 Apr 13; 96(8):4273-8. PMID: 10200252; PMCID: PMC16322.
    60. Heise N, Opperdoes FR. Purification, localisation and characterisation of glucose-6-phosphate dehydrogenase of Trypanosoma brucei. Mol Biochem Parasitol. 1999 Mar 15; 99(1):21-32. PMID: 10215021.
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    61. Hannaert V, Opperdoes FR, Michels PA. Comparison and evolutionary analysis of the glycosomal glyceraldehyde-3-phosphate dehydrogenase from different Kinetoplastida. J Mol Evol. 1998 Dec; 47(6):728-38. PMID: 9847415.
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    62. Adjé CA, Opperdoes FR, Michels PA. Molecular analysis of phosphoglycerate kinase in Trypanoplasma borreli and the evolution of this enzyme in kinetoplastida. Gene. 1998 Sep 14; 217(1-2):91-9. PMID: 9795157.
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    63. Ernest I, Callens M, Uttaro AD, Chevalier N, Opperdoes FR, Muirhead H, Michels PA. Pyruvate kinase of Trypanosoma brucei: overexpression, purification, and functional characterization of wild-type and mutated enzyme. Protein Expr Purif. 1998 Aug; 13(3):373-82. PMID: 9693062.
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    64. Zomer AW, Allert S, Chevalier N, Callens M, Opperdoes FR, Michels PA. Purification and characterisation of the phosphoglycerate kinase isoenzymes of Trypanosoma brucei expressed in Escherichia coli. Biochim Biophys Acta. 1998 Jul 28; 1386(1):179-88. PMID: 9675273.
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    65. Van Hellemond JJ, Opperdoes FR, Tielens AG. Trypanosomatidae produce acetate via a mitochondrial acetate:succinate CoA transferase. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):3036-41. PMID: 9501211; PMCID: PMC19690.
    66. Michels PA, Chevalier N, Opperdoes FR, Rider MH, Rigden DJ. The glycosomal ATP-dependent phosphofructokinase of Trypanosoma brucei must have evolved from an ancestral pyrophosphate-dependent enzyme. Eur J Biochem. 1997 Dec 15; 250(3):698-704. PMID: 9461292.
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    67. Adjé CA, Opperdoes FR, Michels PA. Organization, sequence and stage-specific expression of the phosphoglycerate kinase genes of Leishmania mexicana mexicana. Mol Biochem Parasitol. 1997 Dec 01; 90(1):155-68. PMID: 9497040.
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    68. Uttaro AD, Sanchez-Moreno M, Opperdoes FR. Genus-specific biochemical markers for Phytomonas spp. Mol Biochem Parasitol. 1997 Dec 01; 90(1):337-42. PMID: 9497057.
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    69. Uttaro AD, Opperdoes FR. Characterisation of the two malate dehydrogenases from Phytomonas sp. Purification of the glycosomal isoenzyme. Mol Biochem Parasitol. 1997 Oct; 89(1):51-9. PMID: 9297700.
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    70. Heise N, Opperdoes FR. The dihydroxyacetonephosphate pathway for biosynthesis of ether lipids in Leishmania mexicana promastigotes. Mol Biochem Parasitol. 1997 Oct; 89(1):61-72. PMID: 9297701.
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    71. Uttaro AD, Opperdoes FR. Purification and characterisation of a novel iso-propanol dehydrogenase from Phytomonas sp. Mol Biochem Parasitol. 1997 Apr; 85(2):213-9. PMID: 9106194.
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    72. Bakker BM, Michels PA, Opperdoes FR, Westerhoff HV. Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes. J Biol Chem. 1997 Feb 07; 272(6):3207-15. PMID: 9013556.
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    73. Wiemer EA, IJlst L, van Roy J, Wanders RJ, Opperdoes FR. Identification of 2-enoyl coenzyme A hydratase and NADP(+)-dependent 3-hydroxyacyl-CoA dehydrogenase activity in glycosomes of procyclic Trypanosoma brucei. Mol Biochem Parasitol. 1996 Nov 12; 82(1):107-11. PMID: 8943154.
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    74. Kohl L, Drmota T, Thi CD, Callens M, Van Beeumen J, Opperdoes FR, Michels PA. Cloning and characterization of the NAD-linked glycerol-3-phosphate dehydrogenases of Trypanosoma brucei brucei and Leishmania mexicana mexicana and expression of the trypanosome enzyme in Escherichia coli. Mol Biochem Parasitol. 1996 Feb-Mar; 76(1-2):159-73. PMID: 8920004.
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    75. Bastin P, Stephan A, Raper J, Saint-Remy JM, Opperdoes FR, Courtoy PJ. An M(r) 145,000 low-density lipoprotein (LDL)-binding protein is conserved throughout the Kinetoplastida order. Mol Biochem Parasitol. 1996 Feb-Mar; 76(1-2):43-56. PMID: 8919994.
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    76. Wiemer EA, Michels PA, Opperdoes FR. The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. Biochem J. 1995 Dec 01; 312 ( Pt 2):479-84. PMID: 8526859; PMCID: PMC1136287.
    77. Trinquier M, Perie J, Callens M, Opperdoes F, Willson M. Specific inhibitors for the glycolytic enzymes of Trypanosoma brucei. Bioorg Med Chem. 1995 Nov; 3(11):1423-7. PMID: 8634823.
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    78. Zomer AW, Opperdoes FR, van den Bosch H. Alkyl dihydroxyacetone phosphate synthase in glycosomes of Trypanosoma brucei. Biochim Biophys Acta. 1995 Jul 13; 1257(2):167-73. PMID: 7619857.
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    79. Hannaert V, Opperdoes FR, Michels PA. Glycosomal glyceraldehyde-3-phosphate dehydrogenase of Trypanosoma brucei and Trypanosoma cruzi: expression in Escherichia coli, purification, and characterization of the enzymes. Protein Expr Purif. 1995 Jun; 6(3):244-50. PMID: 7663157.
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    80. Wiemer EA, Hannaert V, van den IJssel PR, Van Roy J, Opperdoes FR, Michels PA. Molecular analysis of glyceraldehyde-3-phosphate dehydrogenase in Trypanoplasma borelli: an evolutionary scenario of subcellular compartmentation in kinetoplastida. J Mol Evol. 1995 Apr; 40(4):443-54. PMID: 7769620.
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    81. Buxbaum LU, Raper J, Opperdoes FR, Englund PT. Myristate exchange. A second glycosyl phosphatidylinositol myristoylation reaction in African trypanosomes. J Biol Chem. 1994 Dec 02; 269(48):30212-20. PMID: 7982929.
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    82. Lukes J, Arts GJ, van den Burg J, de Haan A, Opperdoes F, Sloof P, Benne R. Novel pattern of editing regions in mitochondrial transcripts of the cryptobiid Trypanoplasma borreli. EMBO J. 1994 Nov 01; 13(21):5086-98. PMID: 7525275; PMCID: PMC395455.
    83. Verlinde CL, Callens M, Van Calenbergh S, Van Aerschot A, Herdewijn P, Hannaert V, Michels PA, Opperdoes FR, Hol WG. Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness. J Med Chem. 1994 Oct 14; 37(21):3605-13. PMID: 7932587.
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    84. Chaumont F, Schanck AN, Blum JJ, Opperdoes FR. Aerobic and anaerobic glucose metabolism of Phytomonas sp. isolated from Euphorbia characias. Mol Biochem Parasitol. 1994 Oct; 67(2):321-31. PMID: 7870136.
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    85. Hannaert V, Callens M, Opperdoes FR, Michels PA. Purification and characterization of the native and the recombinant Leishmania mexicana glycosomal glyceraldehyde-3-phosphate dehydrogenase. Eur J Biochem. 1994 Oct 01; 225(1):143-9. PMID: 7925431.
      View in: PubMed
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    92. Prado-Figueroa M, Raper J, Opperdoes FR. Possible localisation of dolichol-dependent mannosyltransferase of Trypanosoma brucei to the rough endoplasmic reticulum. Mol Biochem Parasitol. 1994 Feb; 63(2):255-64. PMID: 7516492.
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    93. Bastin P, Coppens I, Saint-Remy JM, Baudhuin P, Opperdoes FR, Courtoy PJ. Identification of a specific epitope on the extracellular domain of the LDL-receptor of Trypanosoma brucei brucei. Mol Biochem Parasitol. 1994 Feb; 63(2):193-202. PMID: 7516491.
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    97. Vansterkenburg EL, Coppens I, Wilting J, Bos OJ, Fischer MJ, Janssen LH, Opperdoes FR. The uptake of the trypanocidal drug suramin in combination with low-density lipoproteins by Trypanosoma brucei and its possible mode of action. Acta Trop. 1993 Sep; 54(3-4):237-50. PMID: 7902661.
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    106. Bakalara N, Kendall G, Michels PA, Opperdoes FR. Trypanosoma brucei glycosomal glyceraldehyde-3-phosphate dehydrogenase genes are stage-regulated at the transcription level. EMBO J. 1992 Oct; 11(10):3808. PMID: 1396574; PMCID: PMC556841.
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    108. Sanchez-Moreno M, Lasztity D, Coppens I, Opperdoes FR. Characterization of carbohydrate metabolism and demonstration of glycosomes in a Phytomonas sp. isolated from Euphorbia characias. Mol Biochem Parasitol. 1992 Sep; 54(2):185-99. PMID: 1435859.
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    109. Ter Kuile BH, Opperdoes FR. A chemostat study on proline uptake and metabolism of Leishmania donovani. J Protozool. 1992 Sep-Oct; 39(5):555-8. PMID: 1522536.
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    111. Gaspar R, Préat V, Opperdoes FR, Roland M. Macrophage activation by polymeric nanoparticles of polyalkylcyanoacrylates: activity against intracellular Leishmania donovani associated with hydrogen peroxide production. Pharm Res. 1992 Jun; 9(6):782-7. PMID: 1409361.
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    114. Coppens I, Bastin P, Opperdoes FR, Baudhuin P, Courtoy PJ. Trypanosoma brucei brucei: antigenic stability of its LDL receptor and immunological cross-reactivity with the LDL receptor of the mammalian host. Exp Parasitol. 1992 Feb; 74(1):77-86. PMID: 1730273.
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    118. Gaspar R, Opperdoes FR, Préat V, Roland M. Drug targeting with polyalkylcyanoacrylate nanoparticles: in vitro activity of primaquine-loaded nanoparticles against intracellular Leishmania donovani. Ann Trop Med Parasitol. 1992 Feb; 86(1):41-9. PMID: 1616394.
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    119. Swinkels BW, Loiseau A, Opperdoes FR, Borst P. A phosphoglycerate kinase-related gene conserved between Trypanosoma brucei and Crithidia fasciculata. Mol Biochem Parasitol. 1992 Jan; 50(1):69-78. PMID: 1542317.
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    123. Coppens I, Bastin P, Courtoy PJ, Baudhuin P, Opperdoes FR. A rapid method purifies a glycoprotein of Mr 145,000 as the LDL receptor of Trypanosoma brucei brucei. Biochem Biophys Res Commun. 1991 Jul 15; 178(1):185-91. PMID: 2069558.
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    124. Callens M, Kuntz DA, Opperdoes FR. Characterization of pyruvate kinase of Trypanosoma brucei and its role in the regulation of carbohydrate metabolism. Mol Biochem Parasitol. 1991 Jul; 47(1):19-29. PMID: 1857383.
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    125. Callens M, Kuntz DA, Opperdoes FR. Kinetic properties of fructose bisphosphate aldolase from Trypanosoma brucei compared to aldolase from rabbit muscle and Staphylococcus aureus. Mol Biochem Parasitol. 1991 Jul; 47(1):1-9. PMID: 1857377.
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    129. Michels PA, Opperdoes FR. The evolutionary origin of glycosomes. Parasitol Today. 1991 May; 7(5):105-9. PMID: 15463459.
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    132. Wierenga RK, Noble ME, Postma JP, Groendijk H, Kalk KH, Hol WG, Opperdoes FR. The crystal structure of the "open" and the "closed" conformation of the flexible loop of trypanosomal triosephosphate isomerase. Proteins. 1991; 10(1):33-49. PMID: 2062827.
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    133. Noble ME, Wierenga RK, Lambeir AM, Opperdoes FR, Thunnissen AM, Kalk KH, Groendijk H, Hol WG. The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes. Proteins. 1991; 10(1):50-69. PMID: 2062828.
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    134. Jackman SA, Hough DW, Danson MJ, Stevenson KJ, Opperdoes FR. Subcellular localisation of dihydrolipoamide dehydrogenase and detection of lipoic acid in bloodstream forms of Trypanosoma brucei. Eur J Biochem. 1990 Oct 05; 193(1):91-5. PMID: 2226451.
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    135. Opperdoes FR. The glycosome of trypanosomes and Leishmania. Biochem Soc Trans. 1990 Oct; 18(5):729-31. PMID: 2083659.
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    137. Bölow R, Griffiths G, Webster P, Stierhof YD, Opperdoes FR, Overath P. Intracellular localization of the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma brucei. J Cell Sci. 1989 Jun; 93 ( Pt 2):233-40. PMID: 2693469.
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    141. Opperdoes FR. Glycosomes may provide clues to the import of peroxisomal proteins. Trends Biochem Sci. 1988 Jul; 13(7):255-60. PMID: 3076722.
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    143. Coppens I, Opperdoes FR, Courtoy PJ, Baudhuin P. Receptor-mediated endocytosis in the bloodstream form of Trypanosoma brucei. J Protozool. 1987 Nov; 34(4):465-73. PMID: 2828605.
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    145. Van Schaftingen E, Opperdoes FR, Hers HG. Effects of various metabolic conditions and of the trivalent arsenical melarsen oxide on the intracellular levels of fructose 2,6-bisphosphate and of glycolytic intermediates in Trypanosoma brucei. Eur J Biochem. 1987 Aug 03; 166(3):653-61. PMID: 3038548.
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    146. Hart DT, Baudhuin P, Opperdoes FR, de Duve C. Biogenesis of the glycosome in Trypanosoma brucei: the synthesis, translocation and turnover of glycosomal polypeptides. EMBO J. 1987 May; 6(5):1403-11. PMID: 3608983; PMCID: PMC553946.
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    148. Misset O, Van Beeumen J, Lambeir AM, Van der Meer R, Opperdoes FR. Glyceraldehyde-phosphate dehydrogenase from Trypanosoma brucei. Comparison of the glycosomal and cytosolic isoenzymes. Eur J Biochem. 1987 Feb 02; 162(3):501-7. PMID: 3830153.
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    149. Misset O, Opperdoes FR. The phosphoglycerate kinases from Trypanosoma brucei. A comparison of the glycosomal and the cytosolic isoenzymes and their sensitivity towards suramin. Eur J Biochem. 1987 Feb 02; 162(3):493-500. PMID: 3830152.
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    150. Wierenga RK, Swinkels B, Michels PA, Osinga K, Misset O, Van Beeumen J, Gibson WC, Postma JP, Borst P, Opperdoes FR, et al. Common elements on the surface of glycolytic enzymes from Trypanosoma brucei may serve as topogenic signals for import into glycosomes. EMBO J. 1987 Jan; 6(1):215-21. PMID: 3582360; PMCID: PMC553379.
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    155. Michels PA, Poliszczak A, Osinga KA, Misset O, Van Beeumen J, Wierenga RK, Borst P, Opperdoes FR. Two tandemly linked identical genes code for the glycosomal glyceraldehyde-phosphate dehydrogenase in Trypanosoma brucei. EMBO J. 1986 May; 5(5):1049-56. PMID: 3013612; PMCID: PMC1166900.
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    158. Opperdoes FR. Biochemical peculiarities of trypanosomes, African and South American. Br Med Bull. 1985 Apr; 41(2):130-6. PMID: 2992672.
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    159. Pauwels PJ, Opperdoes FR, Trouet A. Effects of antimycin, glucose deprivation, and serum on cultures of neurons, astrocytes, and neuroblastoma cells. J Neurochem. 1985 Jan; 44(1):143-8. PMID: 3964824.
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    160. Misset O, Opperdoes FR. Simultaneous purification of hexokinase, class-I fructose-bisphosphate aldolase, triosephosphate isomerase and phosphoglycerate kinase from Trypanosoma brucei. Eur J Biochem. 1984 Nov 02; 144(3):475-83. PMID: 6489338.
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    161. Hart DT, Opperdoes FR. The occurrence of glycosomes (microbodies) in the promastigote stage of four major Leishmania species. Mol Biochem Parasitol. 1984 Oct; 13(2):159-72. PMID: 6440018.
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    162. Wierenga RK, Hol WG, Misset O, Opperdoes FR. Preliminary crystallographic studies of triosephosphate isomerase from the blood parasite Trypanosoma brucei brucei. J Mol Biol. 1984 Sep 15; 178(2):487-90. PMID: 6492157.
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    163. Hart DT, Misset O, Edwards SW, Opperdoes FR. A comparison of the glycosomes (microbodies) isolated from Trypanosoma brucei bloodstream form and cultured procyclic trypomastigotes. Mol Biochem Parasitol. 1984 May; 12(1):25-35. PMID: 6749187.
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    164. Opperdoes FR. Localization of the initial steps in alkoxyphospholipid biosynthesis in glycosomes (microbodies) of Trypanosoma brucei. FEBS Lett. 1984 Apr 09; 169(1):35-9. PMID: 6562019.
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    165. Opperdoes FR, Baudhuin P, Coppens I, De Roe C, Edwards SW, Weijers PJ, Misset O. Purification, morphometric analysis, and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma brucei. J Cell Biol. 1984 Apr; 98(4):1178-84. PMID: 6715405; PMCID: PMC2113209.
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    167. Pauwels PJ, Opperdoes FR, Trouet A. Effect of oxygen and glucose availability on the glycolytic rate in neuroblastoma cells under different conditions of culture. Neurochem Int. 1984; 6(4):467-73. PMID: 20488070.
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    168. Walter RD, Opperdoes FR. Subcellular distribution of adenylate cyclase, cyclic-AMP phosphodiesterase, protein kinases and phosphoprotein phosphatase in Trypanosoma brucei. Mol Biochem Parasitol. 1982 Nov; 6(5):287-95. PMID: 6294515.
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    169. Opperdoes FR, Van Roy J. Involvement of lysosomes in the uptake of macromolecular material by bloodstream forms of Trypanosoma brucei. Mol Biochem Parasitol. 1982 Sep; 6(3):181-90. PMID: 6127630.
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    170. Opperdoes FR, Cottem D. Involvement of the glycosome of Trypanosoma brucei in carbon dioxide fixation. FEBS Lett. 1982 Jun 21; 143(1):60-4. PMID: 6811317.
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    171. Opperdoes FR, van Roy J. The phospholipases of Trypanosoma brucei bloodstream forms and cultured procyclics. Mol Biochem Parasitol. 1982 May; 5(5):309-19. PMID: 7099206.
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    172. Nwagwu M, Opperdoes FR. Regulation of glycolysis in Trypanosoma brucei: hexokinase and phosphofructokinase activity. Acta Trop. 1982 Mar; 39(1):61-72. PMID: 6122364.
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    173. Opperdoes FR, Steiger RF. Localization of hydrolases in cultured procyclic trypomastigotes of Trypanosoma brucei. Mol Biochem Parasitol. 1981 Dec 31; 4(5-6):311-23. PMID: 7335115.
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    174. Opperdoes FR, Markos A, Steiger RF. Localization of malate dehydrogenase, adenylate kinase and glycolytic enzymes in glycosomes and the threonine pathway in the mitochondrion of cultured procyclic trypomastigotes of Trypanosoma brucei. Mol Biochem Parasitol. 1981 Dec 31; 4(5-6):291-309. PMID: 6801509.
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    175. Visser N, Opperdoes FR, Borst P. Subcellular compartmentation of glycolytic intermediates in Trypanosoma brucei. Eur J Biochem. 1981 Sep 01; 118(3):521-6. PMID: 7297560.
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    176. Opperdoes FR. A rapid method for the isolation of intact glycosomes from Trypanosoma brucei by Percoll -gradient centrifugation in a vertical rotor. Mol Biochem Parasitol. 1981 Jul; 3(3):181-6. PMID: 6265776.
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    177. Hammond DJ, Gutteridge WE, Opperdoes FR. A novel location for two enzymes of de novo pyrimidine biosynthesis in trypanosomes and Leishmania. FEBS Lett. 1981 Jun 01; 128(1):27-9. PMID: 7274454.
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    178. Steiger RF, Opperdoes FR, Bontemps J. Subcellular fractionation of Trypanosoma brucei bloodstream forms with special reference to hydrolases. Eur J Biochem. 1980 Mar; 105(1):163-75. PMID: 6245876.
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    179. Visser N, Opperdoes FR. Glycolysis in Trypanosoma brucei. Eur J Biochem. 1980 Feb; 103(3):623-32. PMID: 6766864.
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    180. Opperdoes FR. Miconazole: an inhibitor of cyanide-insensitive respiration in Trypanosoma brucei. Trans R Soc Trop Med Hyg. 1980; 74(3):423-4. PMID: 6776666.
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    181. Opperdoes FR, Borst P. Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei: the glycosome. FEBS Lett. 1977 Aug 15; 80(2):360-4. PMID: 142663.
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    182. Opperdoes FR, Borst P, Bakker S, Leene W. Localization of glycerol-3-phosphate oxidase in the mitochondrion and particulate NAD+-linked glycerol-3-phosphate dehydrogenase in the microbodies of the bloodstream form to Trypanosoma brucei. Eur J Biochem. 1977 Jun 01; 76(1):29-39. PMID: 142010.
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    183. Opperdoes FR, Borst P, Spits H. Particle-bound enzymes in the bloodstream form of Trypanosoma brucei. Eur J Biochem. 1977 Jun 01; 76(1):21-8. PMID: 195809.
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    184. Fairlamb AH, Opperdoes FR, Borst P. New approach to screening drugs for activity against African trypanosomes. Nature. 1977 Jan 20; 265(5591):270-1. PMID: 834274.
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    185. Opperdoes FR, Aarsen PN, van der Meer C, Borst P. Trypanosoma brucei: an evaluation of salicylhydroxamic acid as a trypanocidal drug. Exp Parasitol. 1976 Oct; 40(2):198-205. PMID: 971725.
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    186. Opperdoes FR, Borst P, Fonck K. The potential use of inhibitors of glycerol-3-phosphate oxidase for chemotherapy of African trypanosomiasis. FEBS Lett. 1976 Feb 15; 62(2):169-72. PMID: 1253981.
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    187. Opperdoes FR, Borst P, de Rijke D. Oligomycin sensitivity of the mitochondrial ATPase as a marker for fly transmissability and the presence of functional kinetoplast DNA in African trypanosomes. Comp Biochem Physiol B. 1976; 55(1):25-30. PMID: 133016.
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    188. Opperdoes FR, Rijke DD, Borst P. Reactions involved in energy transfer in trypanosomes-I. Characterization of the mitochondrial adenine nucleotide translocator and the ATPase of Crithidia luciliae. Comp Biochem Physiol B. 1976; 54(1):7-12. PMID: 131670.
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    189. Berden JA, Opperdoes FR. An antimycin-sensitive cytochrome b component in beef-heart mitochondria. Biochim Biophys Acta. 1972 Apr 20; 267(1):7-14. PMID: 5019476.
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    190. Berden JA, Opperdoes FR, Slater EC. The effect of ATP on the apparent mid-point potentials of cytochrome b and cytochrome c in beef-heart mitochondria. Biochim Biophys Acta. 1972 Feb 28; 256(2):594-9. PMID: 5016551.
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