Loading...
Header Logo
Keywords
Last Name
Institution

Dr Pascal Launois

TitleScientist
InstitutionWorld Health Organization (Switzerland)
AddressGeneva
Switzerland
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    Scientist, Research capacity Strengthening and Knowledge Management (RCS-KM), Special Programme for research and training in tropical diseases (TDR), World Health Organization (WHO), Geneva (CH)
    Doctor of the faculty of Medicine of Reims University (France) with a specialization in immunology of infectious diseases. He also holds a PhD of Immunology (Lyon Claude Bernard I , France). He worked for more than 15 years with members of the International Network Association of the Institute Pasteur (Institut Pasteur, Paris; Institut Pasteur in Dakar (Senegal) and Institut Pasteur de Cayenne, French Guiana) where his main research areas were Leishmaniasis, Tuberculosis and Buruli Ulcer. Since May 2003, he joined the Special Programme for research and training in tropical diseases (TDR) as head of the WHO Immunology Research and Training Center at the University of Lausanne. In 2008, he joined TDR in Geneva a as training manager in the RCS unit. He is also professor at the University of Lausanne since 2003.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Ronet C, Passelli K, Charmoy M, Scarpellino L, Myburgh E, Hauyon La Torre Y, Turco S, Mottram JC, Fasel N, Luther SA, Beverley SM, Launois P, Tacchini-Cottier F. TLR2 Signaling in Skin Nonhematopoietic Cells Induces Early Neutrophil Recruitment in Response to Leishmania major Infection. J Invest Dermatol. 2019 Jun; 139(6):1318-1328. PMID: 30594488.
      View in: PubMed
    2. Halpaap B, Vahedi M, Certain E, Alvarado T, Saint Martin C, Merle C, Mihut M, Launois P. Tracking the career development of scientists in low- and middle-income countries trained through TDR's research capacity strengthening programmes: Learning from monitoring and impact evaluation. PLoS Negl Trop Dis. 2017 Dec; 11(12):e0006112. PMID: 29216192.
      View in: PubMed
    3. Almeida APG, Fouque F, Launois P, Sousa CA, Silveira H. From the Laboratory to the Field: Updating Capacity Building in Medical Entomology. Trends Parasitol. 2017 09; 33(9):664-668. PMID: 28624159.
      View in: PubMed
    4. Henley P, Elango V, Horstick O, Ahmad RA, Maure C, Launois P, Merle C, Nabieva J, Mahendradhata Y. Development of the Good Health Research Practice course: ensuring quality across all health research in humans. Health Res Policy Syst. 2017 Mar 31; 15(1):28. PMID: 28359338.
      View in: PubMed
    5. Julé A, Furtado T, Boggs L, van Loggerenberg F, Ewing V, Vahedi M, Launois P, Lang T. Developing a globally applicable evidence-informed competency framework to support capacity strengthening in clinical research. BMJ Glob Health. 2017; 2(2):e000229. PMID: 28589027.
      View in: PubMed
    6. Gopichandran V, Luyckx VA, Biller-Andorno N, Fairchild A, Singh J, Tran N, Saxena A, Launois P, Reis A, Maher D, Vahedi M. Developing the ethics of implementation research in health. Implement Sci. 2016 12 09; 11(1):161. PMID: 27938400.
      View in: PubMed
    7. Casas J, Lazzari C, Insausti T, Launois P, Fouque F. Mapping of courses on vector biology and vector-borne diseases systems: time for a worldwide effort. Mem Inst Oswaldo Cruz. 2016 Nov; 111(11):717-719. PMID: 27759770.
      View in: PubMed
    8. Hartley MA, Bourreau E, Rossi M, Castiglioni P, Eren RO, Prevel F, Couppié P, Hickerson SM, Launois P, Beverley SM, Ronet C, Fasel N. Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A. PLoS Pathog. 2016 Sep; 12(9):e1005852. PMID: 27658195.
      View in: PubMed
    9. Mahendradhata Y, Nabieva J, Ahmad RA, Henley P, Launois P, Merle C, Maure C, Horstick O, Elango V. Promoting good health research practice in low- and middle-income countries. Glob Health Action. 2016; 9:32474. PMID: 27498965.
      View in: PubMed
    10. Käser M, Maure C, Halpaap BM, Vahedi M, Yamaka S, Launois P, Casamitjana N. Research Capacity Strengthening in Low and Middle Income Countries - An Evaluation of the WHO/TDR Career Development Fellowship Programme. PLoS Negl Trop Dis. 2016 05; 10(5):e0004631. PMID: 27223888.
      View in: PubMed
    11. Mahendradhata Y, Nabieva J, Ahmad RA, Henley P, Launois P, Merle C, Maure C, Horstick O, Elango V. Promoting good health research practice in low- and middle-income countries. Glob Health Action. 2016 Jan; 9(1):32474. PMID: 28156951.
      View in: PubMed
    12. Ogundahunsi OA, Vahedi M, Kamau EM, Aslanyan G, Terry RF, Zicker F, Launois P. Strengthening research capacity--TDR's evolving experience in low- and middle-income countries. PLoS Negl Trop Dis. 2015 Jan; 9(1):e3380. PMID: 25569232.
      View in: PubMed
    13. Ives A, Masina S, Castiglioni P, Prével F, Revaz-Breton M, Hartley MA, Launois P, Fasel N, Ronet C. MyD88 and TLR9 dependent immune responses mediate resistance to Leishmania guyanensis infections, irrespective of Leishmania RNA virus burden. PLoS One. 2014; 9(5):e96766. PMID: 24801628.
      View in: PubMed
    14. Tacchini-Cottier F, Weinkopff T, Launois P. Does T Helper Differentiation Correlate with Resistance or Susceptibility to Infection with L. major? Some Insights From the Murine Model. Front Immunol. 2012; 3:32. PMID: 22566916.
      View in: PubMed
    15. Minja H, Nsanzabana C, Maure C, Hoffmann A, Rumisha S, Ogundahunsi O, Zicker F, Tanner M, Launois P. Impact of health research capacity strengthening in low- and middle-income countries: the case of WHO/TDR programmes. PLoS Negl Trop Dis. 2011 Oct; 5(10):e1351. PMID: 22022630.
      View in: PubMed
    16. Ives A, Ronet C, Prevel F, Ruzzante G, Fuertes-Marraco S, Schutz F, Zangger H, Revaz-Breton M, Lye LF, Hickerson SM, Beverley SM, Acha-Orbea H, Launois P, Fasel N, Masina S. Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. Science. 2011 Feb 11; 331(6018):775-8. PMID: 21311023.
      View in: PubMed
    17. Launois P, Drowart A, Bourreau E, Couppie P, Farber CM, Van Vooren JP, Huygen K. T cell reactivity against mycolyl transferase antigen 85 of M. tuberculosis in HIV-TB coinfected subjects and in AIDS patients suffering from tuberculosis and nontuberculous mycobacterial infections. Clin Dev Immunol. 2011; 2011. PMID: 20936150.
      View in: PubMed
    18. Revaz-Breton M, Ronet C, Ives A, Torre YH, Masina S, Tacchini-Cottier F, Launois P. The MyD88 protein 88 pathway is differently involved in immune responses induced by distinct substrains of Leishmania major. Eur J Immunol. 2010 Jun; 40(6):1697-707. PMID: 20333623.
      View in: PubMed
    19. Charmoy M, Brunner-Agten S, Aebischer D, Auderset F, Launois P, Milon G, Proudfoot AE, Tacchini-Cottier F. Neutrophil-derived CCL3 is essential for the rapid recruitment of dendritic cells to the site of Leishmania major inoculation in resistant mice. PLoS Pathog. 2010 Feb 05; 6(2):e1000755. PMID: 20140197.
      View in: PubMed
    20. Ronet C, Hauyon-La Torre Y, Revaz-Breton M, Mastelic B, Tacchini-Cottier F, Louis J, Launois P. Regulatory B cells shape the development of Th2 immune responses in BALB/c mice infected with Leishmania major through IL-10 production. J Immunol. 2010 Jan 15; 184(2):886-94. PMID: 19966209.
      View in: PubMed
    21. Chakour R, Allenbach C, Desgranges F, Charmoy M, Mauel J, Garcia I, Launois P, Louis J, Tacchini-Cottier F. A new function of the Fas-FasL pathway in macrophage activation. J Leukoc Biol. 2009 Jul; 86(1):81-90. PMID: 19380712.
      View in: PubMed
    22. Bourreau E, Ronet C, Darsissac E, Lise MC, Marie DS, Clity E, Tacchini-Cottier F, Couppie P, Launois P. In leishmaniasis due to Leishmania guyanensis infection, distinct intralesional interleukin-10 and Foxp3 mRNA expression are associated with unresponsiveness to treatment. J Infect Dis. 2009 Feb 15; 199(4):576-9. PMID: 19125672.
      View in: PubMed
    23. Bourreau E, Ronet C, Darcissac E, Lise MC, Sainte Marie D, Clity E, Tacchini-Cottier F, Couppie P, Launois P. Intralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis. Infect Immun. 2009 Apr; 77(4):1465-74. PMID: 19168733.
      View in: PubMed
    24. Launois P, Tacchini-Cottier F, Kieny MP. Cutaneous leishmaniasis: progress towards a vaccine. Expert Rev Vaccines. 2008 Oct; 7(8):1277-87. PMID: 18844599.
      View in: PubMed
    25. Ronet C, Voigt H, Himmelrich H, Doucey MA, Hauyon-La Torre Y, Revaz-Breton M, Tacchini-Cottier F, Bron C, Louis J, Launois P. Leishmania major-specific B cells are necessary for Th2 cell development and susceptibility to L. major LV39 in BALB/c mice. J Immunol. 2008 Apr 01; 180(7):4825-35. PMID: 18354206.
      View in: PubMed
    26. Allenbach C, Launois P, Mueller C, Tacchini-Cottier F. An essential role for transmembrane TNF in the resolution of the inflammatory lesion induced by Leishmania major infection. Eur J Immunol. 2008 Mar; 38(3):720-31. PMID: 18266271.
      View in: PubMed
    27. Launois P, Pingel S, Himmelrich H, Locksley R, Louis J. Different epitopes of the LACK protein are recognized by V beta 4 V alpha 8 CD4+ T cells in H-2b and H-2d mice susceptible to Leishmania major. Microbes Infect. 2007 Sep; 9(11):1260-6. PMID: 17890126.
      View in: PubMed
    28. Bourreau E, Ronet C, Couppié P, Sainte-Marie D, Tacchini-Cottier F, Launois P. IL-10 producing CD8+ T cells in human infection with Leishmania guyanensis. Microbes Infect. 2007 Jul; 9(8):1034-41. PMID: 17544800.
      View in: PubMed
    29. Charmoy M, Megnekou R, Allenbach C, Zweifel C, Perez C, Monnat K, Breton M, Ronet C, Launois P, Tacchini-Cottier F. Leishmania major induces distinct neutrophil phenotypes in mice that are resistant or susceptible to infection. J Leukoc Biol. 2007 Aug; 82(2):288-99. PMID: 17449725.
      View in: PubMed
    30. Kariminia A, Bourreau E, Ronet C, Couppie P, Sainte-Marie D, Tacchini-Cottier F, Launois P. Selective expression of the V beta 14 T cell receptor on Leishmania guyanensis--specific CD8+ T cells during human infection. J Infect Dis. 2007 Mar 01; 195(5):739-47. PMID: 17262718.
      View in: PubMed
    31. Allenbach C, Zufferey C, Perez C, Launois P, Mueller C, Tacchini-Cottier F. Macrophages induce neutrophil apoptosis through membrane TNF, a process amplified by Leishmania major. J Immunol. 2006 Jun 01; 176(11):6656-64. PMID: 16709824.
      View in: PubMed
    32. Gumy A, Aseffa A, Rachinel N, Breton M, Otten L, Tacchini-Cottier F, Röcken M, Doyen N, Acha-Orbea H, Locksley RM, MacDonald HR, Launois P, Louis J. LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major. Eur J Immunol. 2006 Jun; 36(6):1465-73. PMID: 16637008.
      View in: PubMed
    33. Kariminia A, Bourreau E, Pascalis H, Couppié P, Sainte-Marie D, Tacchini-Cottier F, Launois P. Transforming growth factor beta 1 production by CD4+ CD25+ regulatory T cells in peripheral blood mononuclear cells from healthy subjects stimulated with Leishmania guyanensis. Infect Immun. 2005 Sep; 73(9):5908-14. PMID: 16113310.
      View in: PubMed
    34. Prévot G, Marsollier L, Carbonelle B, Pradinaud R, Coupié P, Sainte-Marie D, Bourreau E, Launois P. [Diagnosis of Mycobacterium ulcerans infections in French Guiana]. Presse Med. 2004 Dec 04; 33(21):1516. PMID: 15614174.
      View in: PubMed
    35. Gumy A, Louis JA, Launois P. The murine model of infection with Leishmania major and its importance for the deciphering of mechanisms underlying differences in Th cell differentiation in mice from different genetic backgrounds. Int J Parasitol. 2004 Mar 29; 34(4):433-44. PMID: 15013733.
      View in: PubMed
    36. Prévot G, Bourreau E, Pascalis H, Pradinaud R, Tanghe A, Huygen K, Launois P. Differential production of systemic and intralesional gamma interferon and interleukin-10 in nodular and ulcerative forms of Buruli disease. Infect Immun. 2004 Feb; 72(2):958-65. PMID: 14742541.
      View in: PubMed
    37. Delobel P, Launois P, Djossou F, Sainte-Marie D, Pradinaud R. American cutaneous leishmaniasis, lepromatous leprosy, and pulmonary tuberculosis coinfection with downregulation of the T-helper 1 cell response. Clin Infect Dis. 2003 Sep 01; 37(5):628-33. PMID: 12942392.
      View in: PubMed
    38. Bourreau E, Pascalis H, Prévot G, Kariminia A, Jolly N, Milon G, Buffet P, Michel R, Meynard JB, Boutin JP, Aschimoff D, Launois P. Increased production of interferon-gamma by Leishmania homologue of the mammalian receptor for activated C kinase-reactive CD4+ T cells among human blood mononuclear cells: an early marker of exposure to Leishmania? Scand J Immunol. 2003 Aug; 58(2):201-10. PMID: 12869142.
      View in: PubMed
    39. Pascalis H, Lavergne A, Bourreau E, Prévot-Linguet G, Kariminia A, Pradinaud R, Rafati S, Launois P. Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis. Infect Immun. 2003 May; 71(5):2924-6. PMID: 12704171.
      View in: PubMed
    40. Bourreau E, Gardon J, Pradinaud R, Pascalis H, Prévot-Linguet G, Kariminia A, Pascal L. Th2 responses predominate during the early phases of infection in patients with localized cutaneous leishmaniasis and precede the development of Th1 responses. Infect Immun. 2003 Apr; 71(4):2244-6. PMID: 12654849.
      View in: PubMed
    41. Louis JA, Gumy A, Voigt H, Launois P, Rocken M. The use of the murine model of infection with Leishmania major to reveal the antagonistic effects that IL-4 can exert on T helper cell development and demonstrate that these opposite effects depend upon the nature of the cells targeted for IL-4 signaling. Pathol Biol (Paris). 2003 Mar; 51(2):71-3. PMID: 12801805.
      View in: PubMed
    42. Aseffa A, Gumy A, Launois P, MacDonald HR, Louis JA, Tacchini-Cottier F. The early IL-4 response to Leishmania major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4+CD25+ T cells. J Immunol. 2002 Sep 15; 169(6):3232-41. PMID: 12218142.
      View in: PubMed
    43. Louis J, Gumy A, Voigt H, Röcken M, Launois P. Experimental cutaneous Leishmaniasis: a powerful model to study in vivo the mechanisms underlying genetic differences in Th subset differentiation. Eur J Dermatol. 2002 Jul-Aug; 12(4):316-8. PMID: 12095873.
      View in: PubMed
    44. Bourreau E, Prévot G, Gardon J, Pradinaud R, Hasagewa H, Milon G, Launois P. LACK-specific CD4(+) T cells that induce gamma interferon production in patients with localized cutaneous leishmaniasis during an early stage of infection. Infect Immun. 2002 Jun; 70(6):3122-9. PMID: 12011006.
      View in: PubMed
    45. Launois P, Gumy A, Himmelrich H, Locksley RM, Röcken M, Louis JA. Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4(+) T cells in resistant mice treated once with anti-IL-12 or -IFN-gamma antibodies at the onset of infection with Leishmania major instructs Th2 cell development, resulting in nonhealing lesions. J Immunol. 2002 May 01; 168(9):4628-35. PMID: 11971011.
      View in: PubMed
    46. Bourreau E, Collet M, Prévot G, Milon G, Ashimoff D, Hasagewa H, Parra-Lopez C, Launois P. IFN-gamma-producing CD45RA+CD8+ and IL-10-producing CD45RA-CD4+ T cells generated in response to LACK in naive subjects never exposed to Leishmania. Eur J Immunol. 2002 02; 32(2):510-20. PMID: 11828368.
      View in: PubMed
    47. Bourreau E, Prévot G, Gardon J, Pradinaud R, Launois P. High intralesional interleukin-10 messenger RNA expression in localized cutaneous leishmaniasis is associated with unresponsiveness to treatment. J Infect Dis. 2001 Dec 15; 184(12):1628-30. PMID: 11740743.
      View in: PubMed
    48. Biedermann T, Zimmermann S, Himmelrich H, Gumy A, Egeter O, Sakrauski AK, Seegmüller I, Voigt H, Launois P, Levine AD, Wagner H, Heeg K, Louis JA, Röcken M. IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice. Nat Immunol. 2001 Nov; 2(11):1054-60. PMID: 11600887.
      View in: PubMed
    49. Bourreau E, Prévot G, Pradinaud R, Launois P. Unresponsiveness of specific T cells to IL-12 is associated with active cutaneous leishmaniasis owing to Leishmania guyanensis. Scand J Immunol. 2001 Sep; 54(3):335-9. PMID: 11555399.
      View in: PubMed
    50. Maillard I, Launois P, Himmelrich H, Acha-Orbea H, Diggelmann H, Locksley RM, Louis JA. Functional plasticity of the LACK-reactive Vbeta4-Valpha8 CD4(+) T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility to Leishmania major in BALB / c mice. Eur J Immunol. 2001 Apr; 31(4):1288-96. PMID: 11298356.
      View in: PubMed
    51. Bourreau E, Prévot G, Pradinaud R, Launois P. Interleukin (IL)-13 is the predominant Th2 cytokine in localized cutaneous leishmaniasis lesions and renders specific CD4+ T cells unresponsive to IL-12. J Infect Dis. 2001 Mar 15; 183(6):953-9. PMID: 11237813.
      View in: PubMed
    52. Tacchini-Cottier F, Zweifel C, Belkaid Y, Mukankundiye C, Vasei M, Launois P, Milon G, Louis JA. An immunomodulatory function for neutrophils during the induction of a CD4+ Th2 response in BALB/c mice infected with Leishmania major. J Immunol. 2000 Sep 01; 165(5):2628-36. PMID: 10946291.
      View in: PubMed
    53. Himmelrich H, Launois P, Maillard I, Biedermann T, Tacchini-Cottier F, Locksley RM, Röcken M, Louis JA. In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease. J Immunol. 2000 May 01; 164(9):4819-25. PMID: 10779790.
      View in: PubMed
    54. Himmelrich H, Launois P, Tacchini-Cottier F, Louis JA. Some of the early events underlying Th2 cell maturation and susceptibility to Leishmania major infection in BALB/c mice. Biol Chem. 1999 Jul-Aug; 380(7-8):909-14. PMID: 10494841.
      View in: PubMed
    55. Pingel S, Launois P, Fowell DJ, Turck CW, Southwood S, Sette A, Glaichenhaus N, Louis JA, Locksley RM. Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope. J Exp Med. 1999 Apr 05; 189(7):1111-20. PMID: 10190902.
      View in: PubMed
    56. Launois P, Himmelrich H, Tacchini-Cottier F, Milon G, Louis JA. New insight into the mechanisms underlying Th2 cell development and susceptibility to Leishmania major in BALB/c mice. Microbes Infect. 1999 Jan; 1(1):59-64. PMID: 10847767.
      View in: PubMed
    57. Himmelrich H, Parra-Lopez C, Tacchini-Cottier F, Louis JA, Launois P. The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor beta 2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12. J Immunol. 1998 Dec 01; 161(11):6156-63. PMID: 9834101.
      View in: PubMed
    58. Saldinger PF, Porta N, Launois P, Louis JA, Waanders GA, Bouzouréne H, Michetti P, Blum AL, Corthésy-Theulaz IE. Immunization of BALB/c mice with Helicobacter urease B induces a T helper 2 response absent in Helicobacter infection. Gastroenterology. 1998 Oct; 115(4):891-7. PMID: 9753492.
      View in: PubMed
    59. Louis J, Himmelrich H, Parra-Lopez C, Tacchini-Cottier F, Launois P. Regulation of protective immunity against Leishmania major in mice. Curr Opin Immunol. 1998 Aug; 10(4):459-64. PMID: 9722923.
      View in: PubMed
    60. Launois P, Conceiçao-Silva F, Himmerlich H, Parra-Lopez C, Tacchini-Cottier F, Louis JA. Setting in motion the immune mechanisms underlying genetically determined resistance and susceptibility to infection with Leishmania major. Parasite Immunol. 1998 May; 20(5):223-30. PMID: 9651923.
      View in: PubMed
    61. Maillard I, Launois P, Xenarios I, Louis JA, Acha-Orbea H, Diggelmann H. Immune response to mouse mammary tumor virus in mice lacking the alpha/beta interferon or the gamma interferon receptor. J Virol. 1998 Apr; 72(4):2638-46. PMID: 9525580.
      View in: PubMed
    62. Launois P, Tacchini-Cottier F, Parra-Lopez C, Louis JA. Cytokines in parasitic diseases: the example of cutaneous leishmaniasis. Int Rev Immunol. 1998; 17(1-4):157-80. PMID: 9914947.
      View in: PubMed
    63. Louis JA, Conceiçao-Silva F, Himmelrich H, Tacchini-Cottier F, Launois P. Anti-leishmania effector functions of CD4+ Th1 cells and early events instructing Th2 cell development and susceptibility to Leishmania major in BALB/c mice. Adv Exp Med Biol. 1998; 452:53-60. PMID: 9889959.
      View in: PubMed
    64. Launois P, Maillard I, Pingel S, Swihart KG, Xénarios I, Acha-Orbea H, Diggelmann H, Locksley RM, MacDonald HR, Louis JA. IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Immunity. 1997 May; 6(5):541-9. PMID: 9175832.
      View in: PubMed
    65. Shimamura M, Ohteki T, Launois P, Garcia AM, MacDonald HR. Thymus-independent generation of NK1+ T cells in vitro from fetal liver precursors. J Immunol. 1997 Apr 15; 158(8):3682-9. PMID: 9103431.
      View in: PubMed
    66. Beutner U, Launois P, Ohteki T, Louis JA, MacDonald HR. Natural killer-like T cells develop in SJL mice despite genetically distinct defects in NK1.1 expression and in inducible interleukin-4 production. Eur J Immunol. 1997 Apr; 27(4):928-34. PMID: 9130646.
      View in: PubMed
    67. Launois P, Swihart KG, Milon G, Louis JA. Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness. J Immunol. 1997 Apr 01; 158(7):3317-24. PMID: 9120289.
      View in: PubMed
    68. Launois P, Louis JA, Milon G. The fate and persistence of Leishmania major in mice of different genetic backgrounds: an example of exploitation of the immune system by intracellular parasites. Parasitology. 1997; 115 Suppl:S25-32. PMID: 9571688.
      View in: PubMed
    69. Mattner F, Magram J, Ferrante J, Launois P, Di Padova K, Behin R, Gately MK, Louis JA, Alber G. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur J Immunol. 1996 Jul; 26(7):1553-9. PMID: 8766560.
      View in: PubMed
    70. Launois P, Ohteki T, Swihart K, MacDonald HR, Louis JA. In susceptible mice, Leishmania major induce very rapid interleukin-4 production by CD4+ T cells which are NK1.1-. Eur J Immunol. 1995 Dec; 25(12):3298-307. PMID: 8566015.
      View in: PubMed
    71. Launois P, N'Diaye MN, Cartel JL, Mane I, Drowart A, Van Vooren JP, Sarthou JL, Huygen K. Fibronectin-binding antigen 85 and the 10-kilodalton GroES-related heat shock protein are the predominant TH-1 response inducers in leprosy contacts. Infect Immun. 1995 Jan; 63(1):88-93. PMID: 7806388.
      View in: PubMed
    72. Drowart A, Huygen K, Launois P, Jann E, Nyabenda J, van Vooren JP. IgG humoral response against the antigen 85 complex homologues in leprosy. Scand J Immunol. 1994 Dec; 40(6):643-7. PMID: 7997854.
      View in: PubMed
    73. Launois P, DeLeys R, Niang MN, Drowart A, Andrien M, Dierckx P, Cartel JL, Sarthou JL, Van Vooren JP, Huygen K. T-cell-epitope mapping of the major secreted mycobacterial antigen Ag85A in tuberculosis and leprosy. Infect Immun. 1994 Sep; 62(9):3679-87. PMID: 7520418.
      View in: PubMed
    74. Van Vooren JP, Launois P, Huygen K, Leguenno B, Drowart A. Detection of anti-85A and anti-85B IgG antibodies in HIV-infected patients with active pulmonary tuberculosis. Eur J Clin Microbiol Infect Dis. 1994 May; 13(5):444-6. PMID: 8070466.
      View in: PubMed
    75. Launois P, Niang N'Diaye M, Sarthou JL, Drowart A, Van Vooren JP, Cartel JL, Huygen K. T cell reactivity against antigen 85 but not against the 18- and 65-kD heat shock proteins in the early stages of acquired immunity against Mycobacterium leprae. Clin Exp Immunol. 1994 Apr; 96(1):86-90. PMID: 8149672.
      View in: PubMed
    76. Launois P, N'Diaye Niang M, Drowart A, Van Vooren JP, Sarthou JL, Lalu T, Millan J, Huygen K. IgG response to purified 65- and 70-kDa mycobacterial heat shock proteins and to antigen 85 in leprosy. Int J Lepr Other Mycobact Dis. 1994 Mar; 62(1):48-54. PMID: 8189089.
      View in: PubMed
    77. Launois P, Niang MN, Sarthou JL, Rivier F, Drowart A, Van Vooren JP, Millan J, Huygen K. T-cell stimulation with purified mycobacterial antigens in patients and healthy subjects infected with Mycobacterium leprae: secreted antigen 85 is another immunodominant antigen. Scand J Immunol. 1993 Aug; 38(2):167-76. PMID: 8346416.
      View in: PubMed
    78. Dieye A, Heidrich HG, Rogier C, Trape JF, Launois P, Holder AA, Sarthou JL. Lymphocyte response in vitro to Plasmodium falciparum merozoite antigens in donors from a holoendemic area. Parassitologia. 1993 Jul; 35 Suppl:35-8. PMID: 8233608.
      View in: PubMed
    79. Blum L, Flageul B, Sow S, Launois P, Vignon-Pennamen MD, Coll A, Millan J. Leprosy reversal reaction in HIV-positive patients. Int J Lepr Other Mycobact Dis. 1993 Jun; 61(2):214-7. PMID: 8371030.
      View in: PubMed
    80. Launois P, Vandenbussche P, M'Bayame NN, Drowart A, Van Vooren JP, Sarthou JL, Millan J, Huygen K. IL-6 production in response to purified mycobacterial heat-shock proteins and to antigen 85 in leprosy. Cell Immunol. 1993 May; 148(2):283-90. PMID: 8495494.
      View in: PubMed
    81. Launois P, Niang MN, De Bruyn J, Sarthou JL, Rivier F, Drowart A, Van Vooren JP, Millan J, Huygen K. The major secreted antigen complex (Ag 85) from Mycobacterium bovis bacille Calmette-Guérin is associated with protective T cells in leprosy: a follow-up study of 45 household contacts. J Infect Dis. 1993 May; 167(5):1160-7. PMID: 8486949.
      View in: PubMed
    82. Drowart A, Chanteau S, Huygen K, De Cock M, Cartel JL, De Bruyn J, Launois P, Yernault JC, Van Vooren JP. Effects of chemotherapy on antibody levels directed against PGL-I and 85A and 85B protein antigens in lepromatous patients. Int J Lepr Other Mycobact Dis. 1993 Mar; 61(1):29-34. PMID: 8326178.
      View in: PubMed
    83. Brucker-Davis F, Le Guenno B, Bah A, Griffet P, Launois P. [Pulmonary tuberculosis and HIV seropositivity at the Principal Hospital of Dakar (Senegal)]. Rev Med Interne. 1993 Jan; 14(1):14-20. PMID: 8362103.
      View in: PubMed
    84. Dieye A, Heidrich HG, Rogier C, Trape JF, Launois P, Holder AA, Sarthou JL. Lymphocyte response in vitro to Plasmodium falciparum merozoite antigens in donors from a holoendemic area. Parasitol Res. 1993; 79(8):629-33. PMID: 8295898.
      View in: PubMed
    85. Niang-Ndiaye M, Camara T, Cissokho S, Hane AA, Launois P. [Value of PCR in the diagnosis of tuberculosis in samples negative by direct examination in HIV+ and HIV patients]. Dakar Med. 1993; 38(2):165-7. PMID: 7758375.
      View in: PubMed
    86. Honoré N, Bergh S, Chanteau S, Doucet-Populaire F, Eiglmeier K, Garnier T, Georges C, Launois P, Limpaiboon T, Newton S, et al. Nucleotide sequence of the first cosmid from the Mycobacterium leprae genome project: structure and function of the Rif-Str regions. Mol Microbiol. 1993 Jan; 7(2):207-14. PMID: 8446028.
      View in: PubMed
    87. Launois P, N'Diaye M, Sarthou JL, Millan J, Bach MA. Anti-peripheral nerve antibodies in leprosy patients recognize an epitope shared by the M. leprae 65 kDa heat shock protein. J Autoimmun. 1992 Dec; 5(6):745-57. PMID: 1283301.
      View in: PubMed
    88. Van Vooren JP, Drowart A, De Bruyn J, Launois P, Millan J, Delaporte E, Develoux M, Yernault JC, Huygen K. Humoral responses against the 85A and 85B antigens of Mycobacterium bovis BCG in patients with leprosy and tuberculosis. J Clin Microbiol. 1992 Jun; 30(6):1608-10. PMID: 1624586.
      View in: PubMed
    89. Launois P, Niang M, Dieye A, Sarthou JL, Rivier F, Millan J. Human phagocyte respiratory burst by Mycobacterium bovis BCG and M. leprae: functional activation by BCG is mediated by complement and its receptors on monocytes. Int J Lepr Other Mycobact Dis. 1992 Jun; 60(2):225-33. PMID: 1522364.
      View in: PubMed
    90. Niang M, Griffet P, Hugard L, Launois P. [Diagnosis of tuberculosis by specific DNA amplification directly in samples]. Presse Med. 1992 Mar 14; 21(10):482. PMID: 1533911.
      View in: PubMed
    91. Niang M, Griffet P, Hugard L, Launois P. [Diagnosis of tuberculosis by specific DNA amplification directly in samples]. Dakar Med. 1992; 37(2):179-81. PMID: 1345093.
      View in: PubMed
    92. Blum L, Ogougbemy M, M'Boup S, Grimaud J, Millan J, Launois P, Gaye Y, Le Guenno B, Gaye A, Flageul B. [Epidemiological study of HIV seroprevalence in a leprosy patient population in Senegal]. Acta Leprol. 1992; 8(1):35-41. PMID: 1355946.
      View in: PubMed
    93. Launois P. [Cytokines and leprosy]. Acta Leprol. 1992; 8(1):5-10. PMID: 1523966.
      View in: PubMed
    94. Launois P, Niang M, Dieye A, Sarthou JL. TNF-alpha failed to reverse the M. leprae-induced defective chemiluminescence response of human mononuclear cells. FEMS Microbiol Immunol. 1992 Jan; 4(2):91-6. PMID: 1547026.
      View in: PubMed
    95. Drowart A, Launois P, De Cock M, Huygen K, De Bruyn J, Yernault JC, Van Vooren JP. An isoelectric focusing method for the study of the humoral response against the antigen 85 complex of Mycobacterium bovis BCG in the different forms of leprosy. J Immunol Methods. 1991 Dec 15; 145(1-2):223-8. PMID: 1765655.
      View in: PubMed
    96. Launois P, Blum L, Dieye A, Millan J, Sarthou JL, Michel JC, Bach MA. M. leprae- and BCG-induced chemiluminescence response of monocytes from leprosy patients and healthy subjects: effects of gamma-interferon and GM-CSF. Int J Lepr Other Mycobact Dis. 1991 Dec; 59(4):582-9. PMID: 1802941.
      View in: PubMed
    97. Launois P, Huygen K, De Bruyn J, N'Diaye M, Diouf B, Sarthouj L, Grimaud J, Millan J. T cell response to purified filtrate antigen 85 from Mycobacterium bovis Bacilli Calmette-Guérin (BCG) in leprosy patients. Clin Exp Immunol. 1991 Nov; 86(2):286-90. PMID: 1934596.
      View in: PubMed
    98. Dieye A, Launois P, Sarthou JL. [Research on malaria vaccine]. Dakar Med. 1990; 35(2):268-75. PMID: 2135805.
      View in: PubMed
    99. Launois P, Maillere B, Dieye A, Sarthou JL, Bach MA. Human phagocyte oxidative burst activation by BCG, M. leprae, and atypical mycobacteria: defective activation by M. leprae is not reversed by interferon gamma. Cell Immunol. 1989 Nov; 124(1):168-74. PMID: 2509079.
      View in: PubMed
    100. Launois P, Blum L, Dieye A, Millan J, Sarthou JL, Bach MA. Phenolic glycolipid-1 from M. leprae inhibits oxygen free radical production by human mononuclear cells. Res Immunol. 1989 Nov-Dec; 140(9):847-55. PMID: 2697907.
      View in: PubMed
    101. Launois P, Dieye A, Blum L, Millan J, Sarthou JL. [Macrophage activation and Mycobacterium leprae: effect of interferon gamma on the production of oxygen free radicals by phagocytic cells]. Dakar Med. 1989; 34(1-4):78-82. PMID: 2518818.
      View in: PubMed
    102. Launois P, Maillere B, Dieye A, Sarthou JL, Bach MA. Limiting dilution of murine T cell response to mycobacterial antigens. Acta Leprol. 1989; 7 Suppl 1:179-80. PMID: 2503983.
      View in: PubMed
    103. Sarthou JL, Dieye A, Peytavi D, Launois P, Diagne M, Millan J. [Evaluation by chemiluminescence of the in vitro production of oxygen radicals by phagocytic cells in leprosy]. Acta Leprol. 1989; 7 Suppl 1:181-3. PMID: 2503985.
      View in: PubMed
    104. Desforges S, Launois P, Bobin P, Bach MA. Follow up of T cells subsets and anti-trisaccharide IgM antibody levels of leprosy patients during daily multidrug therapy. Acta Leprol. 1989; 7 Suppl 1:169-70. PMID: 2503979.
      View in: PubMed
    105. Bach MA, Launois P. Mechanisms of Mycobacterium leprae-specific T-cell deficiency in lepromatous leprosy. Biochimie. 1988 Aug; 70(8):1013-8. PMID: 3147697.
      View in: PubMed
    106. Launois P, Shankar P, Wallach D, Flageul B, Cottenot F, Bach MA. Mycobacterium leprae-reactive T-cell clones isolated from polar lepromatous and tuberculoid leprosy patients. Ann Inst Pasteur Immunol. 1987 Sep-Oct; 138(5):723-35. PMID: 2830893.
      View in: PubMed
    Launois's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _