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Professor Frank Brombacher

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hurdayal R, Ndlovu HH, Revaz-Breton M, Parihar SP, Nono JK, Govender M, Brombacher F. IL-4-producing B cells regulate T helper cell dichotomy in type 1- and type 2-controlled diseases. Proc Natl Acad Sci U S A. 2017 Oct 03; 114(40):E8430-E8439. PMID: 28916732.
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    2. Guler R, Brombacher F. Host-directed drug therapy for tuberculosis. Nat Chem Biol. 2015 Oct; 11(10):748-51. PMID: 26379013.
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    3. Guler R, Roy S, Suzuki H, Brombacher F. Targeting Batf2 for infectious diseases and cancer. Oncotarget. 2015 Sep 29; 6(29):26575-82. PMID: 26376615; PMCID: PMC4694937.
    4. Hadebe S, Kirstein F, Fierens K, Chen K, Drummond RA, Vautier S, Sajaniemi S, Murray G, Williams DL, Redelinghuys P, Reinhart TA, Junecko BA, Kolls JK, Lambrecht BN, Brombacher F, Brown GD. Correction: Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma. PLoS One. 2015; 10(9):e0137945. PMID: 26348039; PMCID: PMC4562703.
    5. Hadebe S, Kirstein F, Fierens K, Chen K, Drummond RA, Vautier S, Sajaniemi S, Murray G, Williams DL, Redelinghuys P, Reinhart TA, Fallert Junecko BA, Kolls JK, Lambrecht BN, Brombacher F, Brown GD. Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma. PLoS One. 2015; 10(8):e0134219. PMID: 26261989; PMCID: PMC4532492.
    6. Roy S, Schmeier S, Arner E, Alam T, Parihar SP, Ozturk M, Tamgue O, Kawaji H, de Hoon MJ, Itoh M, Lassmann T, Carninci P, Hayashizaki Y, Forrest AR, Bajic VB, Guler R. Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics. Nucleic Acids Res. 2015 Aug 18; 43(14):6969-82. PMID: 26117544; PMCID: PMC4538831.
    7. Cnops J, De Trez C, Stijlemans B, Keirsse J, Kauffmann F, Barkhuizen M, Keeton R, Boon L, Brombacher F, Magez S. NK-, NKT- and CD8-Derived IFN? Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia. PLoS Pathog. 2015 Jun; 11(6):e1004964. PMID: 26070118; PMCID: PMC4466398.
    8. Roy S, Guler R, Parihar SP, Schmeier S, Kaczkowski B, Nishimura H, Shin JW, Negishi Y, Ozturk M, Hurdayal R, Kubosaki A, Kimura Y, de Hoon MJ, Hayashizaki Y, Brombacher F, Suzuki H. Batf2/Irf1 induces inflammatory responses in classically activated macrophages, lipopolysaccharides, and mycobacterial infection. J Immunol. 2015 Jun 15; 194(12):6035-44. PMID: 25957166.
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    9. Guler R, Parihar SP, Savvi S, Logan E, Schwegmann A, Roy S, Nieuwenhuizen NE, Ozturk M, Schmeier S, Suzuki H, Brombacher F. IL-4Ra-dependent alternative activation of macrophages is not decisive for Mycobacterium tuberculosis pathology and bacterial burden in mice. PLoS One. 2015; 10(3):e0121070. PMID: 25790379; PMCID: PMC4366092.
    10. Arner E, Daub CO, Vitting-Seerup K, Andersson R, Lilje B, Drabløs F, Lennartsson A, Rönnerblad M, Hrydziuszko O, Vitezic M, Freeman TC, Alhendi AM, Arner P, Axton R, Baillie JK, Beckhouse A, Bodega B, Briggs J, Brombacher F, Davis M, Detmar M, Ehrlund A, Endoh M, Eslami A, Fagiolini M, Fairbairn L, Faulkner GJ, Ferrai C, Fisher ME, Forrester L, Goldowitz D, Guler R, Ha T, Hara M, Herlyn M, Ikawa T, Kai C, Kawamoto H, Khachigian LM, Klinken SP, Kojima S, Koseki H, Klein S, Mejhert N, Miyaguchi K, Mizuno Y, Morimoto M, Morris KJ, Mummery C, Nakachi Y, Ogishima S, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov D, Passier R, Patrikakis M, Pombo A, Qin XY, Roy S, Sato H, Savvi S, Saxena A, Schwegmann A, Sugiyama D, Swoboda R, Tanaka H, Tomoiu A, Winteringham LN, Wolvetang E, Yanagi-Mizuochi C, Yoneda M, Zabierowski S, Zhang P, Abugessaisa I, Bertin N, Diehl AD, Fukuda S, Furuno M, Harshbarger J, Hasegawa A, Hori F, Ishikawa-Kato S, Ishizu Y, Itoh M, Kawashima T, Kojima M, Kondo N, Lizio M, Meehan TF, Mungall CJ, Murata M, Nishiyori-Sueki H, Sahin S, Nagao-Sato S, Severin J, de Hoon MJ, Kawai J, Kasukawa T, Lassmann T, Suzuki H, Kawaji H, Summers KM, Wells C. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science. 2015 Feb 27; 347(6225):1010-4. PMID: 25678556.
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    11. Darby M, Schnoeller C, Vira A, Culley FJ, Culley F, Bobat S, Logan E, Kirstein F, Wess J, Cunningham AF, Brombacher F, Selkirk ME, Horsnell WG. The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection. PLoS Pathog. 2015 Jan; 11(1):e1004636. PMID: 25629518; PMCID: PMC4309615.
    12. Chen C, Akiyama K, Wang D, Xu X, Li B, Moshaverinia A, Brombacher F, Sun L, Shi S. mTOR inhibition rescues osteopenia in mice with systemic sclerosis. J Exp Med. 2015 Jan 12; 212(1):73-91. PMID: 25534817; PMCID: PMC4291526.
    13. Bobat S, Darby M, Mrdjen D, Cook C, Logan E, Auret J, Jones E, Schnoeller C, Flores-Langarica A, Ross EA, Vira A, López-Macías C, Henderson IR, Alexander J, Brombacher F, Horsnell WG, Cunningham AF. Natural and vaccine-mediated immunity to Salmonella Typhimurium is impaired by the helminth Nippostrongylus brasiliensis. PLoS Negl Trop Dis. 2014 Dec; 8(12):e3341. PMID: 25474738; PMCID: PMC4256288.
    14. Ndlovu H, Brombacher F. Role of IL-4Ra during acute schistosomiasis in mice. Parasite Immunol. 2014 Sep; 36(9):421-7. PMID: 24127774; PMCID: PMC4286023.
    15. Heitmann L, Abad Dar M, Schreiber T, Erdmann H, Behrends J, Mckenzie AN, Brombacher F, Ehlers S, Hölscher C. The IL-13/IL-4Ra axis is involved in tuberculosis-associated pathology. J Pathol. 2014 Nov; 234(3):338-50. PMID: 24979482; PMCID: PMC4277691.
    16. Imanishi T, Ishihara C, Badr Mel S, Hashimoto-Tane A, Kimura Y, Kawai T, Takeuchi O, Ishii KJ, Taniguchi S, Noda T, Hirano H, Brombacher F, Barber GN, Akira S, Saito T. Nucleic acid sensing by T cells initiates Th2 cell differentiation. Nat Commun. 2014 Apr 10; 5:3566. PMID: 24717539.
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    17. Ndlovu H, Darby M, Froelich M, Horsnell W, Lühder F, Hünig T, Brombacher F. Inducible deletion of CD28 prior to secondary nippostrongylus brasiliensis infection impairs worm expulsion and recall of protective memory CD4? T cell responses. PLoS Pathog. 2014 Feb; 10(2):e1003906. PMID: 24516382; PMCID: PMC3916406.
    18. Grahnert A, Richter T, Piehler D, Eschke M, Schulze B, Müller U, Protschka M, Köhler G, Sabat R, Brombacher F, Alber G. IL-4 receptor-alpha-dependent control of Cryptococcus neoformans in the early phase of pulmonary infection. PLoS One. 2014; 9(1):e87341. PMID: 24475277; PMCID: PMC3903725.
    19. Hurdayal R, Brombacher F. The role of IL-4 and IL-13 in cutaneous Leishmaniasis. Immunol Lett. 2014 Oct; 161(2):179-83. PMID: 24412597.
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    20. Horsnell WG, Darby MG, Hoving JC, Nieuwenhuizen N, McSorley HJ, Ndlovu H, Bobat S, Kimberg M, Kirstein F, Cutler AJ, Dewals B, Cunningham AF, Brombacher F. IL-4Ra-associated antigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection. PLoS Pathog. 2013 Oct; 9(10):e1003662. PMID: 24204255; PMCID: PMC3812011.
    21. Hurdayal R, Nieuwenhuizen NE, Revaz-Breton M, Smith L, Hoving JC, Parihar SP, Reizis B, Brombacher F. Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection. PLoS Pathog. 2013 Oct; 9(10):e1003699. PMID: 24204259; PMCID: PMC3812013.
    22. Parihar SP, Guler R, Khutlang R, Lang DM, Hurdayal R, Mhlanga MM, Suzuki H, Marais AD, Brombacher F. Statin therapy reduces the mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation. J Infect Dis. 2014 Mar 01; 209(5):754-63. PMID: 24133190.
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    23. Jenkins SJ, Ruckerl D, Thomas GD, Hewitson JP, Duncan S, Brombacher F, Maizels RM, Hume DA, Allen JE. IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1. J Exp Med. 2013 Oct 21; 210(11):2477-91. PMID: 24101381; PMCID: PMC3804948.
    24. Parihar SP, Guler R, Lang DM, Suzuki H, Marais AD, Brombacher F. Simvastatin enhances protection against Listeria monocytogenes infection in mice by counteracting Listeria-induced phagosomal escape. PLoS One. 2013; 8(9):e75490. PMID: 24086542; PMCID: PMC3782446.
    25. Nieuwenhuizen NE, Meter JM, Horsnell WG, Hoving JC, Fick L, Sharp MF, Darby MG, Parihar SP, Brombacher F, Lopata AL. A cross-reactive monoclonal antibody to nematode haemoglobin enhances protective immune responses to Nippostrongylus brasiliensis. PLoS Negl Trop Dis. 2013; 7(8):e2395. PMID: 24009787; PMCID: PMC3757078.
    26. Wermeling F, Anthony RM, Brombacher F, Ravetch JV. Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13487-91. PMID: 23898202; PMCID: PMC3746917.
    27. Thawer SG, Horsnell WG, Darby M, Hoving JC, Dewals B, Cutler AJ, Lang D, Brombacher F. Lung-resident CD4? T cells are sufficient for IL-4Ra-dependent recall immunity to Nippostrongylus brasiliensis infection. Mucosal Immunol. 2014 Mar; 7(2):239-48. PMID: 23778354.
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    28. You D, Marr N, Saravia J, Shrestha B, Lee GI, Turvey SE, Brombacher F, Herbert DR, Cormier SA. IL-4Ra on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates. J Leukoc Biol. 2013 Jun; 93(6):933-42. PMID: 23543769; PMCID: PMC3656337.
    29. Müller U, Stenzel W, Piehler D, Grahnert A, Protschka M, Köhler G, Frey O, Held J, Richter T, Eschke M, Kamradt T, Brombacher F, Alber G. Abrogation of IL-4 receptor-a-dependent alternatively activated macrophages is sufficient to confer resistance against pulmonary cryptococcosis despite an ongoing T(h)2 response. Int Immunol. 2013 Aug; 25(8):459-70. PMID: 23532373.
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    30. Zeng MY, Pham D, Bagaitkar J, Liu J, Otero K, Shan M, Wynn TA, Brombacher F, Brutkiewicz RR, Kaplan MH, Dinauer MC. An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD. Blood. 2013 Apr 25; 121(17):3473-83. PMID: 23426944; PMCID: PMC3637016.
    31. Davies LC, Rosas M, Jenkins SJ, Liao CT, Scurr MJ, Brombacher F, Fraser DJ, Allen JE, Jones SA, Taylor PR. Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nat Commun. 2013; 4:1886. PMID: 23695680; PMCID: PMC3842019.
    32. Schmidt S, Hoving JC, Horsnell WG, Mearns H, Cutler AJ, Brombacher TM, Brombacher F. Nippostrongylus-induced intestinal hypercontractility requires IL-4 receptor alpha-responsiveness by T cells in mice. PLoS One. 2012; 7(12):e52211. PMID: 23284939; PMCID: PMC3527412.
    33. du Plessis N, Kleynhans L, Thiart L, van Helden PD, Brombacher F, Horsnell WG, Walzl G. Acute helminth infection enhances early macrophage mediated control of mycobacterial infection. Mucosal Immunol. 2013 Sep; 6(5):931-41. PMID: 23250274.
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    34. Gogishvili T, Lühder F, Kirstein F, Nieuwenhuizen NE, Goebbels S, Beer-Hammer S, Pfeffer K, Reuter S, Taube C, Brombacher F, Hünig T. Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease. J Allergy Clin Immunol. 2012 Dec; 130(6):1394-403.e4. PMID: 23102920.
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    35. Masic A, Hurdayal R, Nieuwenhuizen NE, Brombacher F, Moll H. Dendritic cell-mediated vaccination relies on interleukin-4 receptor signaling to avoid tissue damage after Leishmania major infection of BALB/c mice. PLoS Negl Trop Dis. 2012; 6(7):e1721. PMID: 22802978; PMCID: PMC3389028.
    36. Komai-Koma M, Brombacher F, Pushparaj PN, Arendse B, McSharry C, Alexander J, Chaudhuri R, Thomson NC, McKenzie AN, McInnes I, Liew FY, Xu D. Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice. Allergy. 2012 Sep; 67(9):1118-26. PMID: 22702477; PMCID: PMC3660789.
    37. Nieuwenhuizen NE, Kirstein F, Jayakumar J, Emedi B, Hurdayal R, Horsnell WG, Lopata AL, Brombacher F. Allergic airway disease is unaffected by the absence of IL-4Ra-dependent alternatively activated macrophages. J Allergy Clin Immunol. 2012 Sep; 130(3):743-750.e8. PMID: 22552110.
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    38. Alexander J, Brombacher F. T helper1/t helper2 cells and resistance/susceptibility to leishmania infection: is this paradigm still relevant? Front Immunol. 2012; 3:80. PMID: 22566961; PMCID: PMC3342373.
    39. Link A, Zabel F, Schnetzler Y, Titz A, Brombacher F, Bachmann MF. Innate immunity mediates follicular transport of particulate but not soluble protein antigen. J Immunol. 2012 Apr 15; 188(8):3724-33. PMID: 22427639.
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    40. Müller U, Piehler D, Stenzel W, Köhler G, Frey O, Held J, Grahnert A, Richter T, Eschke M, Kamradt T, Brombacher F, Alber G. Lack of IL-4 receptor expression on T helper cells reduces T helper 2 cell polyfunctionality and confers resistance in allergic bronchopulmonary mycosis. Mucosal Immunol. 2012 May; 5(3):299-310. PMID: 22333910.
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    41. Strasser D, Neumann K, Bergmann H, Marakalala MJ, Guler R, Rojowska A, Hopfner KP, Brombacher F, Urlaub H, Baier G, Brown GD, Leitges M, Ruland J. Syk kinase-coupled C-type lectin receptors engage protein kinase C-s to elicit Card9 adaptor-mediated innate immunity. Immunity. 2012 Jan 27; 36(1):32-42. PMID: 22265677; PMCID: PMC3477316.
    42. Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM, Chawla A. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature. 2011 Nov 20; 480(7375):104-8. PMID: 22101429; PMCID: PMC3371761.
    43. Hoving JC, Kirstein F, Nieuwenhuizen NE, Fick LC, Hobeika E, Reth M, Brombacher F. B cells that produce immunoglobulin E mediate colitis in BALB/c mice. Gastroenterology. 2012 Jan; 142(1):96-108. PMID: 21983080.
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    44. McFarlane E, Carter KC, McKenzie AN, Kaye PM, Brombacher F, Alexander J. Endogenous IL-13 plays a crucial role in liver granuloma maturation during Leishmania donovani infection, independent of IL-4Ra-responsive macrophages and neutrophils. J Infect Dis. 2011 Jul 01; 204(1):36-43. PMID: 21628656; PMCID: PMC3105032.
    45. Perkins C, Yanase N, Smulian G, Gildea L, Orekov T, Potter C, Brombacher F, Aronow B, Wills-Karp M, Finkelman FD. Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice. J Exp Med. 2011 Apr 11; 208(4):853-67. PMID: 21464224; PMCID: PMC3135339.
    46. Cook PC, Aynsley SA, Turner JD, Jenkins GR, Van Rooijen N, Leeto M, Brombacher F, Mountford AP. Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by Th2 conditioning of dermal myeloid cells. PLoS Pathog. 2011 Mar; 7(3):e1001323. PMID: 21445234; PMCID: PMC3060168.
    47. Guler R, Afshar M, Arendse B, Parihar SP, Revaz-Breton M, Leitges M, Schwegmann A, Brombacher F. PKCd regulates IL-12p40/p70 production by macrophages and dendritic cells, driving a type 1 healer phenotype in cutaneous leishmaniasis. Eur J Immunol. 2011 Mar; 41(3):706-15. PMID: 21287553.
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    48. Bryson KJ, Millington OR, Mokgethi T, McGachy HA, Brombacher F, Alexander J. BALB/c mice deficient in CD4 T cell IL-4Ra expression control Leishmania mexicana Load although female but not male mice develop a healer phenotype. PLoS Negl Trop Dis. 2011 Jan 04; 5(1):e930. PMID: 21245915; PMCID: PMC3014948.
    49. van der Ventel ML, Nieuwenhuizen NE, Kirstein F, Hikuam C, Jeebhay MF, Swoboda I, Brombacher F, Lopata AL. Differential responses to natural and recombinant allergens in a murine model of fish allergy. Mol Immunol. 2011 Jan; 48(4):637-46. PMID: 21112638.
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    50. Guler R, Parihar SP, Spohn G, Johansen P, Brombacher F, Bachmann MF. Blocking IL-1a but not IL-1ß increases susceptibility to chronic Mycobacterium tuberculosis infection in mice. Vaccine. 2011 Feb 01; 29(6):1339-46. PMID: 21093494.
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    51. Marakalala MJ, Guler R, Matika L, Murray G, Jacobs M, Brombacher F, Rothfuchs AG, Sher A, Brown GD. The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice. Microbes Infect. 2011 Feb; 13(2):198-201. PMID: 21034845; PMCID: PMC3032049.
    52. Dewals B, Hoving JC, Horsnell WG, Brombacher F. Control of Schistosoma mansoni egg-induced inflammation by IL-4-responsive CD4(+)CD25(-)CD103(+)Foxp3(-) cells is IL-10-dependent. Eur J Immunol. 2010 Oct; 40(10):2837-47. PMID: 20821727.
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    53. Horsnell WG, Vira A, Kirstein F, Mearns H, Hoving JC, Cutler AJ, Dewals B, Myburgh E, Kimberg M, Arendse B, White N, Lopata A, Burger PE, Brombacher F. IL-4Ra-responsive smooth muscle cells contribute to initiation of TH2 immunity and pulmonary pathology in Nippostrongylus brasiliensis infections. Mucosal Immunol. 2011 Jan; 4(1):83-92. PMID: 20737001.
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    54. Uyttenhove C, Brombacher F, Van Snick J. TGF-ß interactions with IL-1 family members trigger IL-4-independent IL-9 production by mouse CD4(+) T cells. Eur J Immunol. 2010 Aug; 40(8):2230-5. PMID: 20540113.
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    55. Hünig T, Lühder F, Elflein K, Gogishvili T, Fröhlich M, Guler R, Cutler A, Brombacher F. CD28 and IL-4: two heavyweights controlling the balance between immunity and inflammation. Med Microbiol Immunol. 2010 Aug; 199(3):239-46. PMID: 20390297; PMCID: PMC3128750.
    56. Kirstein F, Horsnell WG, Nieuwenhuizen N, Ryffel B, Lopata AL, Brombacher F. Anisakis pegreffii-induced airway hyperresponsiveness is mediated by gamma interferon in the absence of interleukin-4 receptor alpha responsiveness. Infect Immun. 2010 Sep; 78(9):4077-86. PMID: 20605987; PMCID: PMC2937453.
    57. Kirstein F, Horsnell WG, Kuperman DA, Huang X, Erle DJ, Lopata AL, Brombacher F. Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma. J Allergy Clin Immunol. 2010 Aug; 126(2):347-54. PMID: 20579713; PMCID: PMC2917502.
    58. Horsnell WG, Brombacher F. Genes associated with alternatively activated macrophages discretely regulate helminth infection and pathogenesis in experimental mouse models. Immunobiology. 2010 Sep-Oct; 215(9-10):704-8. PMID: 20594611.
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    59. Dewals BG, Marillier RG, Hoving JC, Leeto M, Schwegmann A, Brombacher F. IL-4Ralpha-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness. PLoS Negl Trop Dis. 2010 May 18; 4(5):e689. PMID: 20502521; PMCID: PMC2872644.
    60. Marillier RG, Brombacher TM, Dewals B, Leeto M, Barkhuizen M, Govender D, Kellaway L, Horsnell WG, Brombacher F. IL-4R{alpha}-responsive smooth muscle cells increase intestinal hypercontractility and contribute to resistance during acute Schistosomiasis. Am J Physiol Gastrointest Liver Physiol. 2010 Jun; 298(6):G943-51. PMID: 20360135.
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    61. Jones LA, Roberts F, Nickdel MB, Brombacher F, McKenzie AN, Henriquez FL, Alexander J, Roberts CW. IL-33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected with Toxoplasma gondii. Eur J Immunol. 2010 Feb; 40(2):426-36. PMID: 19950183.
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    62. Schäfer G, Guler R, Murray G, Brombacher F, Brown GD. The role of scavenger receptor B1 in infection with Mycobacterium tuberculosis in a murine model. PLoS One. 2009 Dec 24; 4(12):e8448. PMID: 20041149; PMCID: PMC2794535.
    63. Herbert DR, Yang JQ, Hogan SP, Groschwitz K, Khodoun M, Munitz A, Orekov T, Perkins C, Wang Q, Brombacher F, Urban JF, Rothenberg ME, Finkelman FD. Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. J Exp Med. 2009 Dec 21; 206(13):2947-57. PMID: 19995957; PMCID: PMC2806463.
    64. Dewals B, Hoving JC, Leeto M, Marillier RG, Govender U, Cutler AJ, Horsnell WG, Brombacher F. IL-4Ralpha responsiveness of non-CD4 T cells contributes to resistance in schistosoma mansoni infection in pan-T cell-specific IL-4Ralpha-deficient mice. Am J Pathol. 2009 Aug; 175(2):706-16. PMID: 19628763; PMCID: PMC2716945.
    65. Keating P, O'Sullivan D, Tierney JB, Kenwright D, Miromoeini S, Mawasse L, Brombacher F, La Flamme AC. Protection from EAE by IL-4Ralpha(-/-) macrophages depends upon T regulatory cell involvement. Immunol Cell Biol. 2009 Oct; 87(7):534-45. PMID: 19488061.
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    66. The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet. 2009 May; 41(5):553-62. PMID: 19377474.
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    67. Steenwinckel V, Louahed J, Lemaire MM, Sommereyns C, Warnier G, McKenzie A, Brombacher F, Van Snick J, Renauld JC. IL-9 promotes IL-13-dependent paneth cell hyperplasia and up-regulation of innate immunity mediators in intestinal mucosa. J Immunol. 2009 Apr 15; 182(8):4737-43. PMID: 19342650.
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    68. Nieuwenhuizen N, Herbert DR, Brombacher F, Lopata AL. Differential requirements for interleukin (IL)-4 and IL-13 in protein contact dermatitis induced by Anisakis. Allergy. 2009 Sep; 64(9):1309-18. PMID: 19254288.
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    69. Stenzel W, Müller U, Köhler G, Heppner FL, Blessing M, McKenzie AN, Brombacher F, Alber G. IL-4/IL-13-dependent alternative activation of macrophages but not microglial cells is associated with uncontrolled cerebral cryptococcosis. Am J Pathol. 2009 Feb; 174(2):486-96. PMID: 19147811; PMCID: PMC2630557.
    70. Brombacher F, Arendse B, Peterson R, Hölscher A, Hölscher C. Analyzing classical and alternative macrophage activation in macrophage/neutrophil-specific IL-4 receptor-alpha-deficient mice. Methods Mol Biol. 2009; 531:225-52. PMID: 19347321.
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    71. Müller U, Stenzel W, Köhler G, Polte T, Blessing M, Mann A, Piehler D, Brombacher F, Alber G. A gene-dosage effect for interleukin-4 receptor alpha-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis. J Infect Dis. 2008 Dec 01; 198(11):1714-21. PMID: 18954266.
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    72. Barkhuizen M, Magez S, Ryffel B, Brombacher F. Interleukin-12p70 deficiency increases survival and diminishes pathology in Trypanosoma congolense infection. J Infect Dis. 2008 Nov 01; 198(9):1284-91. PMID: 18816189.
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    73. Horsnell WG, Brombacher F. Key roles for specific and nonspecific antibody in intestinal nematode expulsion. Cell Host Microbe. 2008 Oct 16; 4(4):303-5. PMID: 18854231.
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    74. Barbi J, Brombacher F, Satoskar AR. T cells from Leishmania major-susceptible BALB/c mice have a defect in efficiently up-regulating CXCR3 upon activation. J Immunol. 2008 Oct 01; 181(7):4613-20. PMID: 18802063; PMCID: PMC2562238.
    75. Mearns H, Horsnell WG, Hoving JC, Dewals B, Cutler AJ, Kirstein F, Myburgh E, Arendse B, Brombacher F. Interleukin-4-promoted T helper 2 responses enhance Nippostrongylus brasiliensis-induced pulmonary pathology. Infect Immun. 2008 Dec; 76(12):5535-42. PMID: 18809669; PMCID: PMC2583554.
    76. Magez S, Schwegmann A, Atkinson R, Claes F, Drennan M, De Baetselier P, Brombacher F. The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice. PLoS Pathog. 2008 Aug 08; 4(8):e1000122. PMID: 18688274; PMCID: PMC2483930.
    77. Schwegmann A, Brombacher F. Host-directed drug targeting of factors hijacked by pathogens. Sci Signal. 2008 Jul 22; 1(29):re8. PMID: 18648074.
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    78. Marillier RG, Michels C, Smith EM, Fick LC, Leeto M, Dewals B, Horsnell WG, Brombacher F. IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections. BMC Immunol. 2008 Mar 28; 9:11. PMID: 18373844; PMCID: PMC2329604.
    79. Myburgh E, Horsnell WG, Cutler AJ, Arendse B, Kubo M, Brombacher F. Murine IL-4 is able to signal via chimeric human IL-4Ralpha/mouse gamma-chain receptor. Mol Immunol. 2008 Mar; 45(5):1327-36. PMID: 18029018.
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    80. Müller U, Stenzel W, Köhler G, Werner C, Polte T, Hansen G, Schütze N, Straubinger RK, Blessing M, McKenzie AN, Brombacher F, Alber G. IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans. J Immunol. 2007 Oct 15; 179(8):5367-77. PMID: 17911623.
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    81. Schwegmann A, Guler R, Cutler AJ, Arendse B, Horsnell WG, Flemming A, Kottmann AH, Ryan G, Hide W, Leitges M, Seoighe C, Brombacher F. Protein kinase C delta is essential for optimal macrophage-mediated phagosomal containment of Listeria monocytogenes. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16251-6. PMID: 17913887; PMCID: PMC2000452.
    82. Loke P, Gallagher I, Nair MG, Zang X, Brombacher F, Mohrs M, Allison JP, Allen JE. Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection. J Immunol. 2007 Sep 15; 179(6):3926-36. PMID: 17785830.
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    83. Barkhuizen M, Magez S, Atkinson RA, Brombacher F. Interleukin-12p70-dependent interferon- gamma production is crucial for resistance in African trypanosomiasis. J Infect Dis. 2007 Oct 15; 196(8):1253-60. PMID: 17955445.
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    84. Nieuwenhuizen N, Herbert DR, Lopata AL, Brombacher F. CD4+ T cell-specific deletion of IL-4 receptor alpha prevents ovalbumin-induced anaphylaxis by an IFN-gamma-dependent mechanism. J Immunol. 2007 Sep 01; 179(5):2758-65. PMID: 17709489.
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    85. Magez S, Radwanska M, Drennan M, Fick L, Baral TN, Allie N, Jacobs M, Nedospasov S, Brombacher F, Ryffel B, De Baetselier P. Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage-derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing. J Infect Dis. 2007 Sep 15; 196(6):954-62. PMID: 17703428.
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    86. Spohn G, Guler R, Johansen P, Keller I, Jacobs M, Beck M, Rohner F, Bauer M, Dietmeier K, Kündig TM, Jennings GT, Brombacher F, Bachmann MF. A virus-like particle-based vaccine selectively targeting soluble TNF-alpha protects from arthritis without inducing reactivation of latent tuberculosis. J Immunol. 2007 Jun 01; 178(11):7450-7. PMID: 17513796.
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    87. Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, Red Eagle A, Vats D, Brombacher F, Ferrante AW, Chawla A. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature. 2007 Jun 28; 447(7148):1116-20. PMID: 17515919; PMCID: PMC2587297.
    88. Radwanska M, Cutler AJ, Hoving JC, Magez S, Holscher C, Bohms A, Arendse B, Kirsch R, Hunig T, Alexander J, Kaye P, Brombacher F. Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection. PLoS Pathog. 2007 May 11; 3(5):e68. PMID: 17500591; PMCID: PMC1867380.
    89. Baschuk N, Utermöhlen O, Gugel R, Warnecke G, Karow U, Paulsen D, Brombacher F, Krönke M, Deppert W. Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice. Cancer Immunol Immunother. 2007 Oct; 56(10):1625-36. PMID: 17431618.
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    90. Waisman A, Kraus M, Seagal J, Ghosh S, Melamed D, Song J, Sasaki Y, Classen S, Lutz C, Brombacher F, Nitschke L, Rajewsky K. IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta. J Exp Med. 2007 Apr 16; 204(4):747-58. PMID: 17420268; PMCID: PMC2118546.
    91. Baral TN, De Baetselier P, Brombacher F, Magez S. Control of Trypanosoma evansi infection is IgM mediated and does not require a type I inflammatory response. J Infect Dis. 2007 May 15; 195(10):1513-20. PMID: 17436232.
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    92. Cao Y, Brombacher F, Tunyogi-Csapo M, Glant TT, Finnegan A. Interleukin-4 regulates proteoglycan-induced arthritis by specifically suppressing the innate immune response. Arthritis Rheum. 2007 Mar; 56(3):861-70. PMID: 17330244.
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    93. Kleinschek MA, Owyang AM, Joyce-Shaikh B, Langrish CL, Chen Y, Gorman DM, Blumenschein WM, McClanahan T, Brombacher F, Hurst SD, Kastelein RA, Cua DJ. IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med. 2007 Jan 22; 204(1):161-70. PMID: 17200411; PMCID: PMC2118427.
    94. Horsnell WG, Cutler AJ, Hoving JC, Hoving CJ, Mearns H, Myburgh E, Arendse B, Finkelman FD, Owens GK, Erle D, Brombacher F. Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice. PLoS Pathog. 2007 Jan; 3(1):e1. PMID: 17222057; PMCID: PMC1769405.
    95. Schnyder-Candrian S, Togbe D, Couillin I, Mercier I, Brombacher F, Quesniaux V, Fossiez F, Ryffel B, Schnyder B. Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med. 2006 Nov 27; 203(12):2715-25. PMID: 17101734; PMCID: PMC2118159.
    96. Leeto M, Herbert DR, Marillier R, Schwegmann A, Fick L, Brombacher F. TH1-dominant granulomatous pathology does not inhibit fibrosis or cause lethality during murine schistosomiasis. Am J Pathol. 2006 Nov; 169(5):1701-12. PMID: 17071593; PMCID: PMC1780204.
    97. Michels C, Goyal P, Nieuwenhuizen N, Brombacher F. Infection with Syphacia obvelata (pinworm) induces protective Th2 immune responses and influences ovalbumin-induced allergic reactions. Infect Immun. 2006 Oct; 74(10):5926-32. PMID: 16988272; PMCID: PMC1594938.
    98. Gallina G, Dolcetti L, Serafini P, De Santo C, Marigo I, Colombo MP, Basso G, Brombacher F, Borrello I, Zanovello P, Bicciato S, Bronte V. Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest. 2006 Oct; 116(10):2777-90. PMID: 17016559; PMCID: PMC1578632.
    99. Misson P, Brombacher F, Delos M, Lison D, Huaux F. Type 2 immune response associated with silicosis is not instrumental in the development of the disease. Am J Physiol Lung Cell Mol Physiol. 2007 Jan; 292(1):L107-13. PMID: 16997884.
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    100. Balic A, Harcus YM, Taylor MD, Brombacher F, Maizels RM. IL-4R signaling is required to induce IL-10 for the establishment of T(h)2 dominance. Int Immunol. 2006 Oct; 18(10):1421-31. PMID: 16940042.
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    101. Nieuwenhuizen N, Lopata AL, Jeebhay MF, Herbert DR, Robins TG, Brombacher F. Exposure to the fish parasite Anisakis causes allergic airway hyperreactivity and dermatitis. J Allergy Clin Immunol. 2006 May; 117(5):1098-105. PMID: 16675338.
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    102. Magez S, Radwanska M, Drennan M, Fick L, Baral TN, Brombacher F, De Baetselier P. Interferon-gamma and nitric oxide in combination with antibodies are key protective host immune factors during trypanosoma congolense Tc13 Infections. J Infect Dis. 2006 Jun 01; 193(11):1575-83. PMID: 16652287.
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    103. Pace L, Rizzo S, Palombi C, Brombacher F, Doria G. Cutting edge: IL-4-induced protection of CD4+CD25- Th cells from CD4+CD25+ regulatory T cell-mediated suppression. J Immunol. 2006 Apr 01; 176(7):3900-4. PMID: 16547222.
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    104. Ghassabeh GH, De Baetselier P, Brys L, Noël W, Van Ginderachter JA, Meerschaut S, Beschin A, Brombacher F, Raes G. Identification of a common gene signature for type II cytokine-associated myeloid cells elicited in vivo in different pathologic conditions. Blood. 2006 Jul 15; 108(2):575-83. PMID: 16556895.
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    105. Hölscher C, Arendse B, Schwegmann A, Myburgh E, Brombacher F. Impairment of alternative macrophage activation delays cutaneous leishmaniasis in nonhealing BALB/c mice. J Immunol. 2006 Jan 15; 176(2):1115-21. PMID: 16394000.
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    106. Couper KN, Roberts CW, Brombacher F, Alexander J, Johnson LL. Toxoplasma gondii-specific immunoglobulin M limits parasite dissemination by preventing host cell invasion. Infect Immun. 2005 Dec; 73(12):8060-8. PMID: 16299300; PMCID: PMC1307022.
    107. Cutler A, Brombacher F. Cytokine therapy. Ann N Y Acad Sci. 2005 Nov; 1056:16-29. PMID: 16387674.
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    108. Kuperman DA, Huang X, Nguyenvu L, Hölscher C, Brombacher F, Erle DJ. IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production. J Immunol. 2005 Sep 15; 175(6):3746-52. PMID: 16148120.
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    109. Drennan MB, Stijlemans B, Van den Abbeele J, Quesniaux VJ, Barkhuizen M, Brombacher F, De Baetselier P, Ryffel B, Magez S. The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent. J Immunol. 2005 Aug 15; 175(4):2501-9. PMID: 16081822.
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    110. Brys L, Beschin A, Raes G, Ghassabeh GH, Noël W, Brandt J, Brombacher F, De Baetselier P. Reactive oxygen species and 12/15-lipoxygenase contribute to the antiproliferative capacity of alternatively activated myeloid cells elicited during helminth infection. J Immunol. 2005 May 15; 174(10):6095-104. PMID: 15879104.
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    111. Couper KN, Phillips RS, Brombacher F, Alexander J. Parasite-specific IgM plays a significant role in the protective immune response to asexual erythrocytic stage Plasmodium chabaudi AS infection. Parasite Immunol. 2005 May; 27(5):171-80. PMID: 15987340.
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    112. Arendse B, Van Snick J, Brombacher F. IL-9 is a susceptibility factor in Leishmania major infection by promoting detrimental Th2/type 2 responses. J Immunol. 2005 Feb 15; 174(4):2205-11. PMID: 15699153.
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    113. Arras M, Louahed J, Heilier JF, Delos M, Brombacher F, Renauld JC, Lison D, Huaux F. IL-9 protects against bleomycin-induced lung injury: involvement of prostaglandins. Am J Pathol. 2005 Jan; 166(1):107-15. PMID: 15632004; PMCID: PMC1602305.
    114. Raes G, Brys L, Dahal BK, Brandt J, Grooten J, Brombacher F, Vanham G, Noël W, Bogaert P, Boonefaes T, Kindt A, Van den Bergh R, Leenen PJ, De Baetselier P, Ghassabeh GH. Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation. J Leukoc Biol. 2005 Mar; 77(3):321-7. PMID: 15591125.
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    115. Uyttenhove C, Arendse B, Stroobant V, Brombacher F, Van Snick J. Development of an anti-IL-12 p40 auto-vaccine: protection in experimental autoimmune encephalomyelitis at the expense of increased sensitivity to infection. Eur J Immunol. 2004 Dec; 34(12):3572-81. PMID: 15549728.
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    116. McDonald SA, O'Grady JE, Bajaj-Elliott M, Notley CA, Alexander J, Brombacher F, McDonald V. Protection against the early acute phase of Cryptosporidium parvum infection conferred by interleukin-4-induced expression of T helper 1 cytokines. J Infect Dis. 2004 Sep 01; 190(5):1019-25. PMID: 15295711.
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    117. Seki N, Miyazaki M, Suzuki W, Hayashi K, Arima K, Myburgh E, Izuhara K, Brombacher F, Kubo M. IL-4-induced GATA-3 expression is a time-restricted instruction switch for Th2 cell differentiation. J Immunol. 2004 May 15; 172(10):6158-66. PMID: 15128803.
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    118. Herbert DR, Hölscher C, Mohrs M, Arendse B, Schwegmann A, Radwanska M, Leeto M, Kirsch R, Hall P, Mossmann H, Claussen B, Förster I, Brombacher F. Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity. 2004 May; 20(5):623-35. PMID: 15142530.
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    119. Han S, Zhang X, Xu R, Finkelman FD, Brombacher F, Zheng B. IgD+IgM- B cells mount immune responses that exhibit altered antibody repertoire. Eur J Immunol. 2004 Mar; 34(3):661-668. PMID: 14991595.
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    120. Cunningham AF, Serre K, Toellner KM, Khan M, Alexander J, Brombacher F, MacLennan ICM. Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells. Eur J Immunol. 2004 Mar; 34(3):686-694. PMID: 14991598.
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    121. Nickdel MB, Lyons RE, Roberts F, Brombacher F, Hunter CA, Alexander J, Roberts CW. Intestinal pathology during acute toxoplasmosis is IL-4 dependent and unrelated to parasite burden. Parasite Immunol. 2004 Feb; 26(2):75-82. PMID: 15225294.
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    122. Magez S, Truyens C, Merimi M, Radwanska M, Stijlemans B, Brouckaert P, Brombacher F, Pays E, De Baetselier P. P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasis. J Infect Dis. 2004 Feb 01; 189(3):527-39. PMID: 14745712.
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    123. Saeftel M, Krueger A, Arriens S, Heussler V, Racz P, Fleischer B, Brombacher F, Hoerauf A. Mice deficient in interleukin-4 (IL-4) or IL-4 receptor alpha have higher resistance to sporozoite infection with Plasmodium berghei (ANKA) than do naive wild-type mice. Infect Immun. 2004 Jan; 72(1):322-31. PMID: 14688111; PMCID: PMC343943.
    124. Stäger S, Alexander J, Kirby AC, Botto M, Rooijen NV, Smith DF, Brombacher F, Kaye PM. Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses. Nat Med. 2003 Oct; 9(10):1287-92. PMID: 14502281.
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    125. Linehan SA, Coulson PS, Wilson RA, Mountford AP, Brombacher F, Martínez-Pomares L, Gordon S. IL-4 receptor signaling is required for mannose receptor expression by macrophages recruited to granulomata but not resident cells in mice infected with Schistosoma mansoni. Lab Invest. 2003 Aug; 83(8):1223-31. PMID: 12920251.
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    126. Stäger S, Alexander J, Carter KC, Brombacher F, Kaye PM. Both interleukin-4 (IL-4) and IL-4 receptor alpha signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity. Infect Immun. 2003 Aug; 71(8):4804-7. PMID: 12874364; PMCID: PMC166035.
    127. Brombacher F, Kastelein RA, Alber G. Novel IL-12 family members shed light on the orchestration of Th1 responses. Trends Immunol. 2003 Apr; 24(4):207-12. PMID: 12697453.
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    128. Herrmann O, Tarabin V, Suzuki S, Attigah N, Coserea I, Schneider A, Vogel J, Prinz S, Schwab S, Monyer H, Brombacher F, Schwaninger M. Regulation of body temperature and neuroprotection by endogenous interleukin-6 in cerebral ischemia. J Cereb Blood Flow Metab. 2003 Apr; 23(4):406-15. PMID: 12679717.
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    129. Volkmann L, Bain O, Saeftel M, Specht S, Fischer K, Brombacher F, Matthaei KI, Hoerauf A. Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages. Med Microbiol Immunol. 2003 Feb; 192(1):23-31. PMID: 12592560.
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    130. Noël W, Hassanzadeh G, Raes G, Namangala B, Daems I, Brys L, Brombacher F, Baetselier PD, Beschin A. Infection stage-dependent modulation of macrophage activation in Trypanosoma congolense-resistant and -susceptible mice. Infect Immun. 2002 Nov; 70(11):6180-7. PMID: 12379696; PMCID: PMC130440.
    131. Alexander J, Brombacher F, McGachy HA, McKenzie AN, Walker W, Carter KC. An essential role for IL-13 in maintaining a non-healing response following Leishmania mexicana infection. Eur J Immunol. 2002 Oct; 32(10):2923-33. PMID: 12355446.
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    132. Fincham JE, Markus MB, Brombacher F. Vaccination against helminths: influence on HIV/AIDS and TB. Trends Parasitol. 2002 Sep; 18(9):385-6. PMID: 12377251.
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    133. Kopf M, Brombacher F, Bachmann MF. Role of IgM antibodies versus B cells in influenza virus-specific immunity. Eur J Immunol. 2002 Aug; 32(8):2229-36. PMID: 12209635.
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    134. Raes G, De Baetselier P, Noël W, Beschin A, Brombacher F, Hassanzadeh Gh G. Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages. J Leukoc Biol. 2002 Apr; 71(4):597-602. PMID: 11927645.
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    135. Hölscher C, Atkinson RA, Arendse B, Brown N, Myburgh E, Alber G, Brombacher F. A protective and agonistic function of IL-12p40 in mycobacterial infection. J Immunol. 2001 Dec 15; 167(12):6957-66. PMID: 11739515.
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    136. Eriksson U, Kurrer MO, Sebald W, Brombacher F, Kopf M. Dual role of the IL-12/IFN-gamma axis in the development of autoimmune myocarditis: induction by IL-12 and protection by IFN-gamma. J Immunol. 2001 Nov 01; 167(9):5464-9. PMID: 11673566.
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    137. Müller U, Köhler G, Mossmann H, Schaub GA, Alber G, Di Santo JP, Brombacher F, Hölscher C. IL-12-independent IFN-gamma production by T cells in experimental Chagas' disease is mediated by IL-18. J Immunol. 2001 Sep 15; 167(6):3346-53. PMID: 11544324.
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    138. Grunewald SM, Teufel M, Erb K, Nelde A, Mohrs M, Brombacher F, Bröcker EB, Sebald W, Duschl A. Upon prolonged allergen exposure IL-4 and IL-4Ralpha knockout mice produce specific IgE leading to anaphylaxis. Int Arch Allergy Immunol. 2001 Aug; 125(4):322-8. PMID: 11574754.
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    139. Biedermann T, Mailhammer R, Mai A, Sander C, Ogilvie A, Brombacher F, Maier K, Levine AD, Röcken M. Reversal of established delayed type hypersensitivity reactions following therapy with IL-4 or antigen-specific Th2 cells. Eur J Immunol. 2001 May; 31(5):1582-91. PMID: 11465116.
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    140. Fort M, Lesley R, Davidson N, Menon S, Brombacher F, Leach M, Rennick D. IL-4 exacerbates disease in a Th1 cell transfer model of colitis. J Immunol. 2001 Feb 15; 166(4):2793-800. PMID: 11160346.
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    141. Bregenholt S, Berche P, Brombacher F, Di Santo JP. Conventional alpha beta T cells are sufficient for innate and adaptive immunity against enteric Listeria monocytogenes. J Immunol. 2001 Feb 01; 166(3):1871-6. PMID: 11160234.
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    142. Nickdel MB, Roberts F, Brombacher F, Alexander J, Roberts CW. Counter-protective role for interleukin-5 during acute Toxoplasma gondii infection. Infect Immun. 2001 Feb; 69(2):1044-52. PMID: 11160001; PMCID: PMC97985.
    143. Aebischer T, Laforsch S, Hurwitz R, Brombacher F, Meyer TF. Immunity against Helicobacter pylori: significance of interleukin-4 receptor alpha chain status and gender of infected mice. Infect Immun. 2001 Jan; 69(1):556-8. PMID: 11119552; PMCID: PMC97918.
    144. Mountford AP, Hogg KG, Coulson PS, Brombacher F. Signaling via interleukin-4 receptor alpha chain is required for successful vaccination against schistosomiasis in BALB/c mice. Infect Immun. 2001 Jan; 69(1):228-36. PMID: 11119510; PMCID: PMC97876.
    145. Alexander J, Carter KC, Al-Fasi N, Satoskar A, Brombacher F. Endogenous IL-4 is necessary for effective drug therapy against visceral leishmaniasis. Eur J Immunol. 2000 Oct; 30(10):2935-43. PMID: 11069076.
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    146. Houston KM, Wilson EH, Eyres L, Brombacher F, Harnett MM, Alexander J, Harnett W. Presence of phosphorylcholine on a filarial nematode protein influences immunoglobulin G subclass response to the molecule by an interleukin-10-dependent mechanism. Infect Immun. 2000 Sep; 68(9):5466-8. PMID: 10948186; PMCID: PMC101820.
    147. Okano M, Satoskar AR, Abe M, Harn DA, Okano M, Nishizaki K, Takeda Y, Yoshino T, Brombacher F, Satoskar AA. Interleukin-4-independent production of Th2 cytokines by nasal lymphocytes and nasal eosinophilia in murine allergic rhinitis. Allergy. 2000 Aug; 55(8):723-31. PMID: 10955698.
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    148. Hölscher C, Mohrs M, Dai WJ, Köhler G, Ryffel B, Schaub GA, Mossmann H, Brombacher F. Tumor necrosis factor alpha-mediated toxic shock in Trypanosoma cruzi-infected interleukin 10-deficient mice. Infect Immun. 2000 Jul; 68(7):4075-83. PMID: 10858224; PMCID: PMC101698.
    149. Brombacher F. The role of interleukin-13 in infectious diseases and allergy. Bioessays. 2000 Jul; 22(7):646-56. PMID: 10878577.
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    150. Mohrs M, Holscher C, Brombacher F. Interleukin-4 receptor alpha-deficient BALB/c mice show an unimpaired T helper 2 polarization in response to Leishmania major infection. Infect Immun. 2000 Apr; 68(4):1773-80. PMID: 10722563; PMCID: PMC97347.
    151. Brewer JM, Conacher M, Hunter CA, Mohrs M, Brombacher F, Alexander J. Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signaling. J Immunol. 1999 Dec 15; 163(12):6448-54. PMID: 10586035.
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    152. Ochsenbein AF, Fehr T, Lutz C, Suter M, Brombacher F, Hengartner H, Zinkernagel RM. Control of early viral and bacterial distribution and disease by natural antibodies. Science. 1999 Dec 10; 286(5447):2156-9. PMID: 10591647.
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    153. Mohrs M, Ledermann B, Köhler G, Dorfmüller A, Gessner A, Brombacher F. Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling. J Immunol. 1999 Jun 15; 162(12):7302-8. PMID: 10358179.
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    154. Cohn L, Homer RJ, MacLeod H, Mohrs M, Brombacher F, Bottomly K. Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. J Immunol. 1999 May 15; 162(10):6178-83. PMID: 10229862.
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    155. Vink A, Warnier G, Brombacher F, Renauld JC. Interleukin 9-induced in vivo expansion of the B-1 lymphocyte population. J Exp Med. 1999 May 03; 189(9):1413-23. PMID: 10224281; PMCID: PMC2193070.
    156. Brombacher F, Dorfmüller A, Magram J, Dai WJ, Köhler G, Wunderlin A, Palmer-Lehmann K, Gately MK, Alber G. IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes. Int Immunol. 1999 Mar; 11(3):325-32. PMID: 10221644.
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    157. Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB. Requirement for IL-13 independently of IL-4 in experimental asthma. Science. 1998 Dec 18; 282(5397):2261-3. PMID: 9856950; PMCID: PMC3897229.
    158. Andersson A, Dai WJ, Di Santo JP, Brombacher F. Early IFN-gamma production and innate immunity during Listeria monocytogenes infection in the absence of NK cells. J Immunol. 1998 Nov 15; 161(10):5600-6. PMID: 9820538.
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    159. Bozza M, Soares MB, Bozza PT, Satoskar AR, Diacovo TG, Brombacher F, Titus RG, Shoemaker CB, David JR. The PACAP-type I receptor agonist maxadilan from sand fly saliva protects mice against lethal endotoxemia by a mechanism partially dependent on IL-10. Eur J Immunol. 1998 Oct; 28(10):3120-7. PMID: 9808180.
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    160. Coyle AJ, Köhler G, Tsuyuki S, Brombacher F, Kopf M. Eosinophils are not required to induce airway hyperresponsiveness after nematode infection. Eur J Immunol. 1998 Sep; 28(9):2640-7. PMID: 9754552.
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    161. Lutz C, Ledermann B, Kosco-Vilbois MH, Ochsenbein AF, Zinkernagel RM, Köhler G, Brombacher F. IgD can largely substitute for loss of IgM function in B cells. Nature. 1998 Jun 25; 393(6687):797-801. PMID: 9655395.
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    162. Barner M, Mohrs M, Brombacher F, Kopf M. Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses. Curr Biol. 1998 May 21; 8(11):669-72. PMID: 9635196.
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    163. Grunewald SM, Werthmann A, Schnarr B, Klein CE, Bröcker EB, Mohrs M, Brombacher F, Sebald W, Duschl A. An antagonistic IL-4 mutant prevents type I allergy in the mouse: inhibition of the IL-4/IL-13 receptor system completely abrogates humoral immune response to allergen and development of allergic symptoms in vivo. J Immunol. 1998 Apr 15; 160(8):4004-9. PMID: 9558109.
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    164. Hölscher C, Köhler G, Müller U, Mossmann H, Schaub GA, Brombacher F. Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase. Infect Immun. 1998 Mar; 66(3):1208-15. PMID: 9488415; PMCID: PMC108035.
    165. Alexander J, Jebbari H, Bluethmann H, Brombacher F, Roberts CW. The role of IL-4 in adult acquired and congenital toxoplasmosis. Int J Parasitol. 1998 Jan; 28(1):113-20. PMID: 9504339.
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    166. Satoskar A, Brombacher F, Dai WJ, McInnes I, Liew FY, Alexander J, Walker W. SCID mice reconstituted with IL-4-deficient lymphocytes, but not immunocompetent lymphocytes, are resistant to cutaneous leishmaniasis. J Immunol. 1997 Nov 15; 159(10):5005-13. PMID: 9366428.
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    167. Noben-Trauth N, Shultz LD, Brombacher F, Urban JF, Gu H, Paul WE. An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20):10838-43. PMID: 9380721; PMCID: PMC23501.
    168. Monteyne P, Renauld JC, Van Broeck J, Dunne DW, Brombacher F, Coutelier JP. IL-4-independent regulation of in vivo IL-9 expression. J Immunol. 1997 Sep 15; 159(6):2616-23. PMID: 9300680.
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    169. Dai WJ, Bartens W, Köhler G, Hufnagel M, Kopf M, Brombacher F. Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-gamma receptor-deficient mice. J Immunol. 1997 Jun 01; 158(11):5297-304. PMID: 9164949.
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    170. Dai WJ, Köhler G, Brombacher F. Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10-deficient mice. J Immunol. 1997 Mar 01; 158(5):2259-67. PMID: 9036973.
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    171. Nielsen PJ, Lorenz B, Müller AM, Wenger RH, Brombacher F, Simon M, von der Weid T, Langhorne WJ, Mossmann H, Köhler G. Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice. Blood. 1997 Feb 01; 89(3):1058-67. PMID: 9028339.
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    172. Brombacher F, Kopf M. Innate versus acquired immunity in listeriosis. Res Immunol. 1996 Oct-Dec; 147(8-9):505-11. PMID: 9127881.
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    173. Kopf M, Brombacher F, Köhler G, Kienzle G, Widmann KH, Lefrang K, Humborg C, Ledermann B, Solbach W. IL-4-deficient Balb/c mice resist infection with Leishmania major. J Exp Med. 1996 Sep 01; 184(3):1127-36. PMID: 9064329; PMCID: PMC2192785.
    174. Kopf M, Brombacher F, Hodgkin PD, Ramsay AJ, Milbourne EA, Dai WJ, Ovington KS, Behm CA, Köhler G, Young IG, Matthaei KI. IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity. 1996 Jan; 4(1):15-24. PMID: 8574848.
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    175. Battegay M, Fiedler P, Kalinke U, Brombacher F, Zinkernagel RM, Peter HH, Köhler G, Eibel H. Non-tolerant B cells cause autoimmunity in anti-CD8 IgG2a-transgenic mice. Eur J Immunol. 1996 Jan; 26(1):250-8. PMID: 8566075.
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    176. Kopf M, Le Gros G, Coyle AJ, Kosco-Vilbois M, Brombacher F. Immune responses of IL-4, IL-5, IL-6 deficient mice. Immunol Rev. 1995 Dec; 148:45-69. PMID: 8825282.
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    177. Kopf M, Ramsay A, Brombacher F, Baumann H, Freer G, Galanos C, Gutierrez-Ramos JC, Köhler G. Pleiotropic defects of IL-6-deficient mice including early hematopoiesis, T and B cell function, and acute phase responses. Ann N Y Acad Sci. 1995 Jul 21; 762:308-18. PMID: 7545368.
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    178. Brombacher F, Schäfer T, Weissenstein U, Tschopp C, Andersen E, Bürki K, Baumann G. IL-2 promoter-driven lacZ expression as a monitoring tool for IL-2 expression in primary T cells of transgenic mice. Int Immunol. 1994 Feb; 6(2):189-97. PMID: 8155596.
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    179. Eibel H, Brombacher F, Köhler G. Analysis of B-cell tolerance in mice expressing transgenic anti-CD8.2 immunoglobulin M molecules. Res Immunol. 1992 Mar-Apr; 143(3):276-8. PMID: 1631405.
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    180. Brombacher F, Köhler G, Eibel H. B cell tolerance in mice transgenic for anti-CD8 immunoglobulin mu chain. J Exp Med. 1991 Dec 01; 174(6):1335-46. PMID: 1744576; PMCID: PMC2119054.
    181. Berling B, Kolbinger F, Grunert F, Thompson JA, Brombacher F, Buchegger F, von Kleist S, Zimmermann W. Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow. Cancer Res. 1990 Oct 15; 50(20):6534-9. PMID: 2208113.
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    182. Brombacher F, Lamers MC, Köhler G, Eibel H. Elimination of CD8+ thymocytes in transgenic mice expressing an anti-Lyt2.2 immunoglobulin heavy chain gene. EMBO J. 1989 Dec 01; 8(12):3719-26. PMID: 2573519; PMCID: PMC402055.
    183. Kolbinger F, Schwarz K, Brombacher F, von Kleist S, Grunert F. Expression of an NCA cDNA in NIH/3T3 cells yields a 110K glycoprotein, which is anchored into the membrane via glycosyl-phosphatidylinositol. Biochem Biophys Res Commun. 1989 Jun 30; 161(3):1126-34. PMID: 2742579.
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