Loading...
Header Logo
Keywords
Last Name
Institution

Professor Dennis Kyle

Address[no address]
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Pradhan A, Siwo GH, Singh N, Martens B, Balu B, Button-Simons KA, Tan A, Zhang M, Udenze KO, Jiang RH, Ferdig MT, Adams JH, Kyle DE. Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery. Sci Rep. 2015 Nov 06; 5:15930. PMID: 26541648.
      View in: PubMed
    2. Shao CL, Linington RG, Balunas MJ, Centeno A, Boudreau P, Zhang C, Engene N, Spadafora C, Mutka TS, Kyle DE, Gerwick L, Wang CY, Gerwick WH. Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta. J Org Chem. 2015 Aug 21; 80(16):7849-55. PMID: 26222145.
      View in: PubMed
    3. Hott A, Tucker MS, Casandra D, Sparks K, Kyle DE. Fitness of artemisinin-resistant Plasmodium falciparum in vitro. J Antimicrob Chemother. 2015 Oct; 70(10):2787-96. PMID: 26203183.
      View in: PubMed
    4. Baragaña B, Hallyburton I, Lee MC, Norcross NR, Grimaldi R, Otto TD, Proto WR, Blagborough AM, Meister S, Wirjanata G, Ruecker A, Upton LM, Abraham TS, Almeida MJ, Pradhan A, Porzelle A. A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. 2015 06 18; 522(7556):315-20. PMID: 26085270.
      View in: PubMed
    5. Hott A, Casandra D, Sparks KN, Morton LC, Castanares GG, Rutter A, Kyle DE. Artemisinin-resistant Plasmodium falciparum parasites exhibit altered patterns of development in infected erythrocytes. Antimicrob Agents Chemother. 2015; 59(6):3156-67. PMID: 25779582.
      View in: PubMed
    6. Rice CA, Colon BL, Alp M, Göker H, Boykin DW, Kyle DE. Bis-benzimidazole hits against Naegleria fowleri discovered with new high-throughput screens. Antimicrob Agents Chemother. 2015 Apr; 59(4):2037-44. PMID: 25605363.
      View in: PubMed
    7. Waterman C, Calcul L, Beau J, Ma WS, Lebar MD, von Salm JL, Harter C, Mutka T, Morton LC, Maignan P, Barisic B, van Olphen A, Kyle DE, Vrijmoed L, Pang KL, Pearce CJ, Baker BJ. Miniaturized Cultivation of Microbiota for Antimalarial Drug Discovery. Med Res Rev. 2016 Jan; 36(1):144-68. PMID: 25545963.
      View in: PubMed
    8. Jiménez-Díaz MB, Ebert D, Salinas Y, Pradhan A, Lehane AM, Myrand-Lapierre ME, O'Loughlin KG, Shackleford DM, Justino de Almeida M, Carrillo AK, Clark JA, Dennis AS, Diep J, Deng X, Duffy S, Endsley AN, Fedewa G, Guiguemde WA, Gómez MG, Holbrook G, Horst J, Kim CC, Liu J, Lee MC, Matheny A, Martínez MS, Miller G, Rodríguez-Alejandre A, Sanz L, Sigal M, Spillman NJ, Stein PD, Wang Z, Zhu F, Waterson D, Knapp S, Shelat A, Avery VM, Fidock DA, Gamo FJ, Charman SA, Mirsalis JC, Ma H, Ferrer S, Kirk K, Angulo-Barturen I, Kyle DE, DeRisi JL, Floyd DM, Guy RK. (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):E5455-62. PMID: 25453091.
      View in: PubMed
    9. Cross RM, Flanigan DL, Monastyrskyi A, LaCrue AN, Sáenz FE, Maignan JR, Mutka TS, White KL, Shackleford DM, Bathurst I, Fronczek FR, Wojtas L, Guida WC, Charman SA, Burrows JN, Kyle DE, Manetsch R. Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium. J Med Chem. 2014 Nov 13; 57(21):8860-79. PMID: 25148516.
      View in: PubMed
    10. Maher SP, Crouse RB, Conway AJ, Bannister EC, Achyuta AK, Clark AY, Sinatra FL, Cuiffi JD, Adams JH, Kyle DE, Saadi WM. Microphysical space of a liver sinusoid device enables simplified long-term maintenance of chimeric mouse-expanded human hepatocytes. Biomed Microdevices. 2014 Oct; 16(5):727-36. PMID: 24907052.
      View in: PubMed
    11. Van Horn KS, Zhu X, Pandharkar T, Yang S, Vesely B, Vanaerschot M, Dujardin JC, Rijal S, Kyle DE, Wang MZ, Werbovetz KA, Manetsch R. Antileishmanial activity of a series of N²,N4-disubstituted quinazoline-2,4-diamines. J Med Chem. 2014 Jun 26; 57(12):5141-56. PMID: 24874647.
      View in: PubMed
    12. Chen N, LaCrue AN, Teuscher F, Waters NC, Gatton ML, Kyle DE, Cheng Q. Fatty acid synthesis and pyruvate metabolism pathways remain active in dihydroartemisinin-induced dormant ring stages of Plasmodium falciparum. Antimicrob Agents Chemother. 2014 Aug; 58(8):4773-81. PMID: 24913167.
      View in: PubMed
    13. von Salm JL, Wilson NG, Vesely BA, Kyle DE, Cuce J, Baker BJ. Shagenes A and B, new tricyclic sesquiterpenes produced by an undescribed Antarctic octocoral. Org Lett. 2014 May 16; 16(10):2630-3. PMID: 24779517.
      View in: PubMed
    14. Monastyrskyi A, Kyle DE, Manetsch R. 4(1H)-pyridone and 4(1H)-quinolone derivatives as antimalarials with erythrocytic, exoerythrocytic, and transmission blocking activities. Curr Top Med Chem. 2014; 14(14):1693-705. PMID: 25116582.
      View in: PubMed
    15. Calcul L, Waterman C, Ma WS, Lebar MD, Harter C, Mutka T, Morton L, Maignan P, Van Olphen A, Kyle DE, Vrijmoed L, Pang KL, Pearce C, Baker BJ. Screening mangrove endophytic fungi for antimalarial natural products. Mar Drugs. 2013 Dec 12; 11(12):5036-50. PMID: 24351903.
      View in: PubMed
    16. Rojas-Silva P, Graziose R, Vesely B, Poulev A, Mbeunkui F, Grace MH, Kyle DE, Lila MA, Raskin I. Leishmanicidal activity of a daucane sesquiterpene isolated from Eryngium foetidum. Pharm Biol. 2014 Mar; 52(3):398-401. PMID: 24147866.
      View in: PubMed
    17. Henrich PP, O'Brien C, Sáenz FE, Cremers S, Kyle DE, Fidock DA. Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model. Antimicrob Agents Chemother. 2014; 58(1):183-95. PMID: 24145526.
      View in: PubMed
    18. Sáenz FE, Lacrue AN, Cross RM, Maignan JR, Udenze KO, Manetsch R, Kyle DE. 4-(1H)-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10H)-ones prevent the transmission of Plasmodium falciparum to Anopheles freeborni. Antimicrob Agents Chemother. 2013 Dec; 57(12):6187-95. PMID: 24080648.
      View in: PubMed
    19. Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE, Morrisey JM, Steuten J, Mutka T, Li Y, Wirjanata G, Ryan E, Duffy S, Kelly JX, Sebayang BF, Zeeman AM, Noviyanti R, Sinden RE, Kocken CHM, Price RN, Avery VM, Angulo-Barturen I, Jiménez-Díaz MB, Ferrer S, Herreros E, Sanz LM, Gamo FJ, Bathurst I, Burrows JN, Siegl P, Guy RK, Winter RW, Vaidya AB, Charman SA, Kyle DE, Manetsch R, Riscoe MK. Quinolone-3-diarylethers: a new class of antimalarial drug. Sci Transl Med. 2013 Mar 20; 5(177):177ra37. PMID: 23515079.
      View in: PubMed
    20. Lacrue AN, Sáenz FE, Cross RM, Udenze KO, Monastyrskyi A, Stein S, Mutka TS, Manetsch R, Kyle DE. 4(1H)-Quinolones with liver stage activity against Plasmodium berghei. Antimicrob Agents Chemother. 2013 Jan; 57(1):417-24. PMID: 23129047.
      View in: PubMed
    21. Srivastava A, Sweat JM, Azizan A, Vesely B, Kyle DE. Real-time PCR to quantify Leishmania donovani in hamsters. J Parasitol. 2013 Feb; 99(1):145-50. PMID: 22924923.
      View in: PubMed
    22. Balunas MJ, Grosso MF, Villa FA, Engene N, McPhail KL, Tidgewell K, Pineda LM, Gerwick L, Spadafora C, Kyle DE, Gerwick WH. Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins. Org Lett. 2012 Aug 03; 14(15):3878-81. PMID: 22794317.
      View in: PubMed
    23. Lowes D, Pradhan A, Iyer LV, Parman T, Gow J, Zhu F, Furimsky A, Lemoff A, Guiguemde WA, Sigal M, Clark JA, Wilson E, Tang L, Connelly MC, Derisi JL, Kyle DE, Mirsalis J, Guy RK. Lead optimization of antimalarial propafenone analogues. J Med Chem. 2012 Jul 12; 55(13):6087-93. PMID: 22708838.
      View in: PubMed
    24. Sáenz FE, Mutka T, Udenze K, Oduola AM, Kyle DE. Novel 4-aminoquinoline analogs highly active against the blood and sexual stages of Plasmodium in vivo and in vitro. Antimicrob Agents Chemother. 2012 Sep; 56(9):4685-92. PMID: 22710117.
      View in: PubMed
    25. Zhang Y, Clark JA, Connelly MC, Zhu F, Min J, Guiguemde WA, Pradhan A, Iyer L, Furimsky A, Gow J, Parman T, El Mazouni F, Phillips MA, Kyle DE, Mirsalis J, Guy RK. Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials. J Med Chem. 2012 May 10; 55(9):4205-19. PMID: 22435599.
      View in: PubMed
    26. Beau J, Mahid N, Burda WN, Harrington L, Shaw LN, Mutka T, Kyle DE, Barisic B, van Olphen A, Baker BJ. Epigenetic tailoring for the production of anti-infective cytosporones from the marine fungus Leucostoma persoonii. Mar Drugs. 2012 Apr; 10(4):762-74. PMID: 22690142.
      View in: PubMed
    27. Cross RM, Namelikonda NK, Mutka TS, Luong L, Kyle DE, Manetsch R. Synthesis, antimalarial activity, and structure-activity relationship of 7-(2-phenoxyethoxy)-4(1H)-quinolones. J Med Chem. 2011 Dec 22; 54(24):8321-7. PMID: 22111907.
      View in: PubMed
    28. Tucker MS, Mutka T, Sparks K, Patel J, Kyle DE. Phenotypic and genotypic analysis of in vitro-selected artemisinin-resistant progeny of Plasmodium falciparum. Antimicrob Agents Chemother. 2012 Jan; 56(1):302-14. PMID: 22083467.
      View in: PubMed
    29. LaCrue AN, Scheel M, Kennedy K, Kumar N, Kyle DE. Effects of artesunate on parasite recrudescence and dormancy in the rodent malaria model Plasmodium vinckei. PLoS One. 2011; 6(10):e26689. PMID: 22039533.
      View in: PubMed
    30. Teuscher F, Chen N, Kyle DE, Gatton ML, Cheng Q. Phenotypic changes in artemisinin-resistant Plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition. Antimicrob Agents Chemother. 2012 Jan; 56(1):428-31. PMID: 21986828.
      View in: PubMed
    31. Lebar MD, Hahn KN, Mutka T, Maignan P, McClintock JB, Amsler CD, van Olphen A, Kyle DE, Baker BJ. CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs. Bioorg Med Chem. 2011 Oct 01; 19(19):5756-62. PMID: 21907583.
      View in: PubMed
    32. Dow GS, Gettayacamin M, Hansukjariya P, Imerbsin R, Komcharoen S, Sattabongkot J, Kyle D, Milhous W, Cozens S, Kenworthy D, Miller A, Veazey J, Ohrt C. Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta). Malar J. 2011 Jul 29; 10:212. PMID: 21801400.
      View in: PubMed
    33. Cross RM, Maignan JR, Mutka TS, Luong L, Sargent J, Kyle DE, Manetsch R. Optimization of 1,2,3,4-tetrahydroacridin-9(10H)-ones as antimalarials utilizing structure-activity and structure-property relationships. J Med Chem. 2011 Jul 14; 54(13):4399-426. PMID: 21630666.
      View in: PubMed
    34. Codd A, Teuscher F, Kyle DE, Cheng Q, Gatton ML. Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure. Malar J. 2011 Mar 08; 10:56. PMID: 21385409.
      View in: PubMed
    35. Kaewpongsri S, Sriprawat K, Suwanarusk R, Kyle DE, Lek-Uthai U, Leimanis M, Lwin KM, Phyo AP, Zwang J, Russell B, Nosten F, Renia L. The presence of leukocytes in ex vivo assays significantly increases the 50-percent inhibitory concentrations of artesunate and chloroquine against Plasmodium vivax and Plasmodium falciparum. Antimicrob Agents Chemother. 2011 Mar; 55(3):1300-4. PMID: 21189344.
      View in: PubMed
    36. Teuscher F, Gatton ML, Chen N, Peters J, Kyle DE, Cheng Q. Artemisinin-induced dormancy in plasmodium falciparum: duration, recovery rates, and implications in treatment failure. J Infect Dis. 2010 Nov 01; 202(9):1362-8. PMID: 20863228.
      View in: PubMed
    37. Cross RM, Monastyrskyi A, Mutka TS, Burrows JN, Kyle DE, Manetsch R. Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity. J Med Chem. 2010 Oct 14; 53(19):7076-94. PMID: 20828199.
      View in: PubMed
    38. Sanchez LM, Lopez D, Vesely BA, Della Togna G, Gerwick WH, Kyle DE, Linington RG. Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds. J Med Chem. 2010 May 27; 53(10):4187-97. PMID: 20441198.
      View in: PubMed
    39. Chen N, Chavchich M, Peters JM, Kyle DE, Gatton ML, Cheng Q. Deamplification of pfmdr1-containing amplicon on chromosome 5 in Plasmodium falciparum is associated with reduced resistance to artelinic acid in vitro. Antimicrob Agents Chemother. 2010 Aug; 54(8):3395-401. PMID: 20421397.
      View in: PubMed
    40. Wang MZ, Zhu X, Srivastava A, Liu Q, Sweat JM, Pandharkar T, Stephens CE, Riccio E, Parman T, Munde M, Mandal S, Madhubala R, Tidwell RR, Wilson WD, Boykin DW, Hall JE, Kyle DE, Werbovetz KA. Novel arylimidamides for treatment of visceral leishmaniasis. Antimicrob Agents Chemother. 2010 Jun; 54(6):2507-16. PMID: 20368397.
      View in: PubMed
    41. Chavchich M, Gerena L, Peters J, Chen N, Cheng Q, Kyle DE. Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum. Antimicrob Agents Chemother. 2010 Jun; 54(6):2455-64. PMID: 20350946.
      View in: PubMed
    42. Balunas MJ, Linington RG, Tidgewell K, Fenner AM, Ureña LD, Togna GD, Kyle DE, Gerwick WH. Dragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity. J Nat Prod. 2010 Jan; 73(1):60-6. PMID: 20030365.
      View in: PubMed
    43. Ma WS, Mutka T, Vesley B, Amsler MO, McClintock JB, Amsler CD, Perman JA, Singh MP, Maiese WM, Zaworotko MJ, Kyle DE, Baker BJ. Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp. J Nat Prod. 2009 Oct; 72(10):1842-6. PMID: 19848433.
      View in: PubMed
    44. Obaldía N, Milhous W, Kyle D. Adaptation of a Thai multidrug-resistant C2A clone of Plasmodium falciparum to Aotus monkeys and its preliminary in vivo antimalarial drug efficacy-resistance profile. Am J Trop Med Hyg. 2009 Oct; 81(4):587-94. PMID: 19815871.
      View in: PubMed
    45. Bacon DJ, Tang D, Salas C, Roncal N, Lucas C, Gerena L, Tapia L, Llanos-Cuentas AA, Garcia C, Solari L, Kyle D, Magill AJ. Effects of point mutations in Plasmodium falciparum dihydrofolate reductase and dihydropterate synthase genes on clinical outcomes and in vitro susceptibility to sulfadoxine and pyrimethamine. PLoS One. 2009 Aug 26; 4(8):e6762. PMID: 19707564.
      View in: PubMed
    46. Obaldia N, Kotecka BM, Edstein MD, Haynes RK, Fugmann B, Kyle DE, Rieckmann KH. Evaluation of artemisone combinations in Aotus monkeys infected with Plasmodium falciparum. Antimicrob Agents Chemother. 2009 Aug; 53(8):3592-4. PMID: 19506062.
      View in: PubMed
    47. Cruz AK, de Toledo JS, Falade M, Terrão MC, Kamchonwongpaisan S, Kyle DE, Uthaipibull C. Current treatment and drug discovery against Leishmania spp. and Plasmodium spp.: a review. Curr Drug Targets. 2009 Mar; 10(3):178-92. PMID: 19275555.
      View in: PubMed
    48. Linington RG, Clark BR, Trimble EE, Almanza A, Ureña LD, Kyle DE, Gerwick WH. Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. J Nat Prod. 2009 Jan; 72(1):14-7. PMID: 19161344.
      View in: PubMed
    49. Greenwood BM, Fidock DA, Kyle DE, Kappe SH, Alonso PL, Collins FH, Duffy PE. Malaria: progress, perils, and prospects for eradication. J Clin Invest. 2008 Apr; 118(4):1266-76. PMID: 18382739.
      View in: PubMed
    50. Guan J, Wang X, Smith K, Ager A, Gettayacamin M, Kyle DE, Milhous WK, Kozar MP, Magill AJ, Lin AJ. Malaria causal prophylactic activity of imidazolidinedione derivatives. J Med Chem. 2007 Nov 29; 50(24):6226-31. PMID: 17967003.
      View in: PubMed
    51. Bacon DJ, Jambou R, Fandeur T, Le Bras J, Wongsrichanalai C, Fukuda MM, Ringwald P, Sibley CH, Kyle DE. World Antimalarial Resistance Network (WARN) II: in vitro antimalarial drug susceptibility. Malar J. 2007 Sep 06; 6:120. PMID: 17822533.
      View in: PubMed
    52. Edstein MD, Kotecka BM, Ager AL, Smith KS, DiTusa CA, Diaz DS, Kyle DE, Schiehser GA, Jacobus DP, Rieckmann KH, O'Neil MT. Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate--JPC2056--in cynomolgus monkeys using an in vivo in vitro model. J Antimicrob Chemother. 2007 Oct; 60(4):811-8. PMID: 17646199.
      View in: PubMed
    53. Li Q, Gerena L, Xie L, Zhang J, Kyle D, Milhous W. Development and validation of flow cytometric measurement for parasitemia in cultures of P. falciparum vitally stained with YOYO-1. Cytometry A. 2007 May; 71(5):297-307. PMID: 17279569.
      View in: PubMed
    54. Xie L, Li Q, Johnson J, Zhang J, Milhous W, Kyle D. Development and validation of flow cytometric measurement for parasitaemia using autofluorescence and YOYO-1 in rodent malaria. Parasitology. 2007 Aug; 134(Pt 9):1151-62. PMID: 17445324.
      View in: PubMed
    55. Miroshnikova OV, Hudson TH, Gerena L, Kyle DE, Lin AJ. Synthesis and antimalarial activity of new isotebuquine analogues. J Med Chem. 2007 Feb 22; 50(4):889-96. PMID: 17266295.
      View in: PubMed
    56. Happi CT, Gbotosho GO, Folarin OA, Milner D, Sarr O, Sowunmi A, Kyle DE, Milhous WK, Wirth DF, Oduola AM. Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa. Malar J. 2006 Oct 04; 5:82. PMID: 17020611.
      View in: PubMed
    57. Gbotosho GO, Ogundahunsi OA, Happi CT, Kyle DE, Gerena L, Milhous WK, Sowunmi A, Oduola AM, Salako LA. The effects of alpha1-acid glycoprotein on the reversal of chloroquine resistance in Plasmodium falciparum. Ann Trop Med Parasitol. 2006 Oct; 100(7):571-8. PMID: 16989682.
      View in: PubMed
    58. Fowler EV, Chavchich M, Chen N, Peters JM, Kyle DE, Gatton ML, Cheng Q. Physical linkage to drug resistance genes results in conservation of var genes among West Pacific Plasmodium falciparum isolates. J Infect Dis. 2006 Oct 01; 194(7):939-48. PMID: 16960782.
      View in: PubMed
    59. Happi CT, Gbotosho GO, Folarin OA, Sowunmi A, Bolaji OM, Fateye BA, Kyle DE, Milhous W, Wirth DF, Oduola AM. Linkage disequilibrium between two distinct loci in chromosomes 5 and 7 of Plasmodium falciparum and in vivo chloroquine resistance in Southwest Nigeria. Parasitol Res. 2006 Dec; 100(1):141-8. PMID: 16874478.
      View in: PubMed
    60. Happi CT, Gbotosho GO, Folarin OA, Bolaji OM, Sowunmi A, Kyle DE, Milhous W, Wirth DF, Oduola AM. Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria. Am J Trop Med Hyg. 2006 Jul; 75(1):155-61. PMID: 16837724.
      View in: PubMed
    61. Kosaisavee V, Suwanarusk R, Nosten F, Kyle DE, Barrends M, Jones J, Price R, Russell B, Lek-Uthai U. Plasmodium vivax: isotopic, PicoGreen, and microscopic assays for measuring chloroquine sensitivity in fresh and cryopreserved isolates. Exp Parasitol. 2006 Sep; 114(1):34-9. PMID: 16545375.
      View in: PubMed
    62. Haynes RK, Fugmann B, Stetter J, Rieckmann K, Heilmann HD, Chan HW, Cheung MK, Lam WL, Wong HN, Croft SL, Vivas L, Rattray L, Stewart L, Peters W, Robinson BL, Edstein MD, Kotecka B, Kyle DE, Beckermann B, Gerisch M, Radtke M, Schmuck G, Steinke W, Wollborn U, Schmeer K, Römer A. Artemisone--a highly active antimalarial drug of the artemisinin class. Angew Chem Int Ed Engl. 2006 Mar 20; 45(13):2082-8. PMID: 16444785.
      View in: PubMed
    63. Heppner DG, Walsh DS, Uthaimongkol N, Tang DB, Tulyayon S, Permpanich B, Wimonwattrawatee T, Chuanak N, Laoboonchai A, Sookto P, Brewer TG, McDaniel P, Eamsila C, Yongvanitchit K, Uhl K, Kyle DE, Keep LW, Miller RE, Wongsrichanalai C. Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western Thailand. Am J Trop Med Hyg. 2005 Nov; 73(5):842-9. PMID: 16282291.
      View in: PubMed
    64. Zhang Q, Guan J, Sacci J, Ager A, Ellis W, Milhous W, Kyle D, Lin AJ. Unambiguous synthesis and prophylactic antimalarial activities of imidazolidinedione derivatives. J Med Chem. 2005 Oct 06; 48(20):6472-81. PMID: 16190773.
      View in: PubMed
    65. Edstein MD, Kotecka BM, Anderson KL, Pombo DJ, Kyle DE, Rieckmann KH, Good MF. Lengthy antimalarial activity of atovaquone in human plasma following atovaquone-proguanil administration. Antimicrob Agents Chemother. 2005 Oct; 49(10):4421-2. PMID: 16189139.
      View in: PubMed
    66. Happi CT, Gbotosho GO, Folarin OA, Akinboye DO, Yusuf BO, Ebong OO, Sowunmi A, Kyle DE, Milhous W, Wirth DF, Oduola AM. Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected patients from Nigeria. Acta Trop. 2005 Sep; 95(3):183-93. PMID: 16023986.
      View in: PubMed
    67. Baker J, McCarthy J, Gatton M, Kyle DE, Belizario V, Luchavez J, Bell D, Cheng Q. Genetic diversity of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and its effect on the performance of PfHRP2-based rapid diagnostic tests. J Infect Dis. 2005 Sep 01; 192(5):870-7. PMID: 16088837.
      View in: PubMed
    68. Chen N, Wilson DW, Pasay C, Bell D, Martin LB, Kyle D, Cheng Q. Origin and dissemination of chloroquine-resistant Plasmodium falciparum with mutant pfcrt alleles in the Philippines. Antimicrob Agents Chemother. 2005 May; 49(5):2102-5. PMID: 15855538.
      View in: PubMed
    69. Haynes RK, Chan HW, Ho WY, Ko CK, Gerena L, Kyle DE, Peters W, Robinson BL. Convenient access both to highly antimalaria-active 10-arylaminoartemisinins, and to 10-alkyl ethers including artemether, arteether, and artelinate. Chembiochem. 2005 Apr; 6(4):659-67. PMID: 15812783.
      View in: PubMed
    70. Mbaisi A, Liyala P, Eyase F, Achilla R, Akala H, Wangui J, Mwangi J, Osuna F, Alam U, Smoak BL, Davis JM, Kyle DE, Coldren RL, Mason C, Waters NC. Drug susceptibility and genetic evaluation of Plasmodium falciparum isolates obtained in four distinct geographical regions of Kenya. Antimicrob Agents Chemother. 2004 Sep; 48(9):3598-601. PMID: 15328137.
      View in: PubMed
    71. Roberts CW, Roberts F, Henriquez FL, Akiyoshi D, Samuel BU, Richards TA, Milhous W, Kyle D, McIntosh L, Hill GC, Chaudhuri M, Tzipori S, McLeod R. Evidence for mitochondrial-derived alternative oxidase in the apicomplexan parasite Cryptosporidium parvum: a potential anti-microbial agent target. Int J Parasitol. 2004 Mar 09; 34(3):297-308. PMID: 15003491.
      View in: PubMed
    72. Teja-Isavadharm P, Peggins JO, Brewer TG, White NJ, Webster HK, Kyle DE. Plasmodium falciparum-based bioassay for measurement of artemisinin derivatives in plasma or serum. Antimicrob Agents Chemother. 2004 Mar; 48(3):954-60. PMID: 14982789.
      View in: PubMed
    73. Happi CT, Gbotosho GO, Sowunmi A, Falade CO, Akinboye DO, Gerena L, Kyle DE, Milhous W, Wirth DF, Oduola AM. Molecular analysis of Plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in Nigeria. Am J Trop Med Hyg. 2004 Jan; 70(1):20-6. PMID: 14971693.
      View in: PubMed
    74. Chen N, Kyle DE, Pasay C, Fowler EV, Baker J, Peters JM, Cheng Q. pfcrt Allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines. Antimicrob Agents Chemother. 2003 Nov; 47(11):3500-5. PMID: 14576108.
      View in: PubMed
    75. Woodard CL, Li Z, Kathcart AK, Terrell J, Gerena L, Lopez-Sanchez M, Kyle DE, Bhattacharjee AK, Nichols DA, Ellis W, Prigge ST, Geyer JA, Waters NC. Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases. J Med Chem. 2003 Aug 28; 46(18):3877-82. PMID: 12930149.
      View in: PubMed
    76. Opsenica D, Angelovski G, Pocsfalvi G, Juranic Z, Zizak Z, Kyle D, Milhous WK, Solaja BA. Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes. Bioorg Med Chem. 2003 Jul 03; 11(13):2761-8. PMID: 12788350.
      View in: PubMed
    77. Happi TC, Thomas SM, Gbotosho GO, Falade CO, Akinboye DO, Gerena L, Hudson T, Sowunmi A, Kyle DE, Milhous W, Wirth DF, Oduola AM. Point mutations in the pfcrt and pfmdr-1 genes of Plasmodium falciparum and clinical response to chloroquine, among malaria patients from Nigeria. Ann Trop Med Parasitol. 2003 Jul; 97(5):439-51. PMID: 12930607.
      View in: PubMed
    78. Li QG, Si YZ, Lee P, Wong E, Xie LH, Kyle DE, Dow GS. Efficacy comparison of intravenous artelinate and artesunate in Plasmodium berghei-infected Sprague-Dawley rats. Parasitology. 2003 Apr; 126(Pt 4):283-91. PMID: 12741507.
      View in: PubMed
    79. Bhattacharjee AK, Kyle DE, Vennerstrom JL, Milhous WK. A 3D QSAR pharmacophore model and quantum chemical structure--activity analysis of chloroquine(CQ)-resistance reversal. J Chem Inf Comput Sci. 2002 Sep-Oct; 42(5):1212-20. PMID: 12377011.
      View in: PubMed
    80. Zhu S, Hudson TH, Kyle DE, Lin AJ. Synthesis and in vitro studies of novel pyrimidinyl peptidomimetics as potential antimalarial therapeutic agents. J Med Chem. 2002 Aug 01; 45(16):3491-6. PMID: 12139460.
      View in: PubMed
    81. Riel MA, Kyle DE, Bhattacharjee AK, Milhous WK. Efficacy of proton pump inhibitor drugs against Plasmodium falciparum in vitro and their probable pharmacophores. Antimicrob Agents Chemother. 2002 Aug; 46(8):2627-32. PMID: 12121943.
      View in: PubMed
    82. Guan J, Kyle DE, Gerena L, Zhang Q, Milhous WK, Lin AJ. Design, synthesis, and evaluation of new chemosensitizers in multi-drug-resistant Plasmodium falciparum. J Med Chem. 2002 Jun 20; 45(13):2741-8. PMID: 12061877.
      View in: PubMed
    83. Hua DH, Tamura M, Huang X, Stephany HA, Helfrich BA, Perchellet EM, Sperfslage BJ, Perchellet JP, Jiang S, Kyle DE, Chiang PK. Syntheses and bioactivities of substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetrones. Unusual reactivities with amines. J Org Chem. 2002 May 03; 67(9):2907-12. PMID: 11975545.
      View in: PubMed
    84. Li QG, Mog SR, Si YZ, Kyle DE, Gettayacamin M, Milhous WK. Neurotoxicity and efficacy of arteether related to its exposure times and exposure levels in rodents. Am J Trop Med Hyg. 2002 May; 66(5):516-25. PMID: 12201585.
      View in: PubMed
    85. Riel MA, Kyle DE, Milhous WK. Efficacy of scopadulcic acid A against Plasmodium falciparum in vitro. J Nat Prod. 2002 Apr; 65(4):614-5. PMID: 11975516.
      View in: PubMed
    86. Emerson LR, Nau ME, Martin RK, Kyle DE, Vahey M, Wirth DF. Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2002 Mar; 46(3):787-96. PMID: 11850263.
      View in: PubMed
    87. Roberts CW, Roberts F, Lyons RE, Kirisits MJ, Mui EJ, Finnerty J, Johnson JJ, Ferguson DJ, Coggins JR, Krell T, Coombs GH, Milhous WK, Kyle DE, Tzipori S, Barnwell J, Dame JB, Carlton J, McLeod R. The shikimate pathway and its branches in apicomplexan parasites. J Infect Dis. 2002 Feb 15; 185 Suppl 1:S25-36. PMID: 11865437.
      View in: PubMed
    88. Zhang P, Nicholson DE, Bujnicki JM, Su X, Brendle JJ, Ferdig M, Kyle DE, Milhous WK, Chiang PK. Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis. J Biomed Sci. 2002 Jan-Feb; 9(1):34-40. PMID: 11810023.
      View in: PubMed
    89. Teja-Isavadharm P, Watt G, Eamsila C, Jongsakul K, Li Q, Keeratithakul G, Sirisopana N, Luesutthiviboon L, Brewer TG, Kyle DE. Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria. Am J Trop Med Hyg. 2001 Dec; 65(6):717-21. PMID: 11791963.
      View in: PubMed
    90. Mehlotra RK, Fujioka H, Roepe PD, Janneh O, Ursos LM, Jacobs-Lorena V, McNamara DT, Bockarie MJ, Kazura JW, Kyle DE, Fidock DA, Zimmerman PA. Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12689-94. PMID: 11675500.
      View in: PubMed
    91. Bhattacharjee AK, Kyle DE, Vennerstrom JL. Structural analysis of chloroquine resistance reversal by imipramine analogs. Antimicrob Agents Chemother. 2001 Sep; 45(9):2655-7. PMID: 11502547.
      View in: PubMed
    92. Jiang S, Prigge ST, Wei L. New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsins. Antimicrob Agents Chemother. 2001 Sep; 45(9):2577-84. PMID: 11502532.
      View in: PubMed
    93. Suswam E, Kyle D, Lang-Unnasch N. Plasmodium falciparum: the effects of atovaquone resistance on respiration. Exp Parasitol. 2001 Aug; 98(4):180-7. PMID: 11560411.
      View in: PubMed
    94. Krudsood S, Singhasivanon P, Silachamroon U, Treeprasertsuk S, Kaivipakbanyai W, Chalermrut K, Phophak N, Horton J, Kyle D, Looareesuwan S. Clinical trial of halofantrine with modified doses for treatment of malaria in the hospital for tropical diseases. Southeast Asian J Trop Med Public Health. 2001 Jun; 32(2):255-61. PMID: 11556573.
      View in: PubMed
    95. Munasinghe A, Patankar S, Cook BP, Madden SL, Martin RK, Kyle DE, Shoaibi A, Cummings LM, Wirth DF. Serial analysis of gene expression (SAGE) in Plasmodium falciparum: application of the technique to A-T rich genomes. Mol Biochem Parasitol. 2001 Mar; 113(1):23-34. PMID: 11254951.
      View in: PubMed
    96. Pattanapanyasat K, Kotipun K, Yongvanitchit K, Hider RC, Kyle DE, Heppner DG, Walsh DS. Effects of hydroxypyridinone iron chelators in combination with antimalarial drugs on the in vitro growth of Plasmodium falciparum. Southeast Asian J Trop Med Public Health. 2001 Mar; 32(1):64-9. PMID: 11485097.
      View in: PubMed
    97. McLeod R, Muench SP, Rafferty JB, Kyle DE, Mui EJ, Kirisits MJ, Mack DG, Roberts CW, Samuel BU, Lyons RE, Dorris M, Milhous WK, Rice DW. Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I. Int J Parasitol. 2001 Feb; 31(2):109-13. PMID: 11239932.
      View in: PubMed
    98. Simpson JA, Watkins ER, Price RN, Aarons L, Kyle DE, White NJ. Mefloquine pharmacokinetic-pharmacodynamic models: implications for dosing and resistance. Antimicrob Agents Chemother. 2000 Dec; 44(12):3414-24. PMID: 11083649.
      View in: PubMed
    99. Ma J, Katz E, Kyle DE, Ziffer H. Syntheses and antimalarial activities of 10-substituted deoxoartemisinins. J Med Chem. 2000 Nov 02; 43(22):4228-32. PMID: 11063619.
      View in: PubMed
    100. Vasconcelos KF, Plowe CV, Fontes CJ, Kyle D, Wirth DF, Pereira da Silva LH, Zalis MG. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase of isolates from the Amazon region of Brazil. Mem Inst Oswaldo Cruz. 2000 Sep-Oct; 95(5):721-8. PMID: 10998224.
      View in: PubMed
    101. Opsenica D, Pocsfalvi G, Juranic Z, Tinant B, Declercq JP, Kyle DE, Milhous WK, Solaja BA. Cholic acid derivatives as 1,2,4,5-tetraoxane carriers: structure and antimalarial and antiproliferative activity. J Med Chem. 2000 Aug 24; 43(17):3274-82. PMID: 10966746.
      View in: PubMed
    102. Ma J, Weiss E, Kyle DE, Ziffer H. Acid catalyzed Michael additions to artemisitene. Bioorg Med Chem Lett. 2000 Jul 17; 10(14):1601-3. PMID: 10915061.
      View in: PubMed
    103. Vennerstrom JL, Dong Y, Andersen SL, Ager AL, Fu H, Miller RE, Wesche DL, Kyle DE, Gerena L, Walters SM, Wood JK, Edwards G, Holme AD, McLean WG, Milhous WK. Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes. J Med Chem. 2000 Jul 13; 43(14):2753-8. PMID: 10893313.
      View in: PubMed
    104. Petras JM, Young GD, Bauman RA, Kyle DE, Gettayacamin M, Webster HK, Corcoran KD, Peggins JO, Vane MA, Brewer TG. Arteether-induced brain injury in Macaca mulatta. I. The precerebellar nuclei: the lateral reticular nuclei, paramedian reticular nuclei, and perihypoglossal nuclei. Anat Embryol (Berl). 2000 May; 201(5):383-97. PMID: 10839633.
      View in: PubMed
    105. Nau ME, Emerson LR, Martin RK, Kyle DE, Wirth DF, Vahey M. Technical assessment of the affymetrix yeast expression GeneChip YE6100 platform in a heterologous model of genes that confer resistance to antimalarial drugs in yeast. J Clin Microbiol. 2000 May; 38(5):1901-8. PMID: 10790119.
      View in: PubMed
    106. Mekonnen B, Weiss E, Katz E, Ma J, Ziffer H, Kyle DE. Synthesis and antimalarial activities of base-catalyzed adducts of 11-azaartemisinin. Bioorg Med Chem. 2000 May; 8(5):1111-6. PMID: 10882021.
      View in: PubMed
    107. McCullough KJ, Wood JK, Bhattacharjee AK, Dong Y, Kyle DE, Milhous WK, Vennerstrom JL. Methyl-substituted dispiro-1,2,4,5-tetraoxanes: correlations of structural studies with antimalarial activity. J Med Chem. 2000 Mar 23; 43(6):1246-9. PMID: 10737758.
      View in: PubMed
    108. Katz E, Ma J, Kyle D, Ziffer H. Structure and antimalarial activity of adducts of 11-azaartemisinin with conjugated terminal acetylenes. Bioorg Med Chem Lett. 1999 Oct 18; 9(20):2969-72. PMID: 10571157.
      View in: PubMed
    109. Walsh DS, Looareesuwan S, Wilairatana P, Heppner DG, Tang DB, Brewer TG, Chokejindachai W, Viriyavejakul P, Kyle DE, Milhous WK, Schuster BG, Horton J, Braitman DJ, Brueckner RP. Randomized dose-ranging study of the safety and efficacy of WR 238605 (Tafenoquine) in the prevention of relapse of Plasmodium vivax malaria in Thailand. J Infect Dis. 1999 Oct; 180(4):1282-7. PMID: 10479159.
      View in: PubMed
    110. Newton P, Keeratithakul D, Teja-Isavadharm P, Pukrittayakamee S, Kyle D, White N. Pharmacokinetics of quinine and 3-hydroxyquinine in severe falciparum malaria with acute renal failure. Trans R Soc Trop Med Hyg. 1999 Jan-Feb; 93(1):69-72. PMID: 10492795.
      View in: PubMed
    111. Wongsrichanalai C, Wimonwattrawatee T, Sookto P, Laoboonchai A, Heppner DG, Kyle DE, Wernsdorfer WH. In vitro sensitivity of Plasmodium falciparum to artesunate in Thailand. Bull World Health Organ. 1999; 77(5):392-8. PMID: 10361756.
      View in: PubMed
    112. Aldous WK, Martin RK, Kyle DE. Stage specific detection and inhibition studies of Plasmodium falciparum telomerase. Mol Biochem Parasitol. 1998 Sep 15; 95(2):281-5. PMID: 9803419.
      View in: PubMed
    113. Roberts F, Roberts CW, Johnson JJ, Kyle DE, Krell T, Coggins JR, Coombs GH, Milhous WK, Tzipori S, Ferguson DJ, Chakrabarti D, McLeod R. Evidence for the shikimate pathway in apicomplexan parasites. Nature. 1998 Jun 25; 393(6687):801-5. PMID: 9655396.
      View in: PubMed
    114. Oduola AM, Sowunmi A, Milhous WK, Brewer TG, Kyle DE, Gerena L, Rossan RN, Salako LA, Schuster BG. In vitro and in vivo reversal of chloroquine resistance in Plasmodium falciparum with promethazine. Am J Trop Med Hyg. 1998 May; 58(5):625-9. PMID: 9598452.
      View in: PubMed
    115. Kyle DE, Teja-Isavadharm P, Li Q, Leo K. Pharmacokinetics and pharmacodynamics of qinghaosu derivatives: how do they impact on the choice of drug and the dosage regimens? Med Trop (Mars). 1998; 58(3 Suppl):38-44. PMID: 10212896.
      View in: PubMed
    116. Luxemburger C, Nosten F, Kyle DE, Kiricharoen L, Chongsuphajaisiddhi T, White NJ. Clinical features cannot predict a diagnosis of malaria or differentiate the infecting species in children living in an area of low transmission. Trans R Soc Trop Med Hyg. 1998 Jan-Feb; 92(1):45-9. PMID: 9692150.
      View in: PubMed
    117. Oduola AM, Omitowoju GO, Sowunmi A, Makler MT, Falade CO, Kyle DE, Fehintola FA, Ogundahunsi OA, Piper RC, Schuster BG, Milhous WK. Plasmodium falciparum: evaluation of lactate dehydrogenase in monitoring therapeutic responses to standard antimalarial drugs in Nigeria. Exp Parasitol. 1997 Nov; 87(3):283-9. PMID: 9371095.
      View in: PubMed
    118. Pichyangkul S, Saengkrai P, Yongvanitchit K, Heppner DG, Kyle DE, Webster HK. Regulation of leukocyte adhesion molecules CD11b/CD18 and leukocyte adhesion molecule-1 on phagocytic cells activated by malaria pigment. Am J Trop Med Hyg. 1997 Oct; 57(4):383-8. PMID: 9347950.
      View in: PubMed
    119. Migasena S, Heppner DG, Kyle DE, Chongsuphajaisiddhi T, Gordon DM, Suntharasamai P, Permpanich B, Brockman A, Pitiuttutham P, Wongsrichanalai C, Srisuriya P, Phonrat B, Pavanand K, Viravan C, Ballou WR. SPf66 malaria vaccine is safe and immunogenic in malaria naive adults in Thailand. Acta Trop. 1997 Sep 30; 67(3):215-27. PMID: 9241386.
      View in: PubMed
    120. Looareesuwan S, Wilairatana P, Viravan C, Vanijanonta S, Pitisuttithum P, Kyle DE. Open randomized trial of oral artemether alone and a sequential combination with mefloquine for acute uncomplicated falciparum malaria. Am J Trop Med Hyg. 1997 Jun; 56(6):613-7. PMID: 9230790.
      View in: PubMed
    121. Nosten F, Luxemburger C, Kyle DE, Gordon DM, Ballou WR, Sadoff JC, Brockman A, Permpanich B, Chongsuphajaisiddhi T, Heppner DG. Phase I trial of the SPf66 malaria vaccine in a malaria-experienced population in Southeast Asia. Am J Trop Med Hyg. 1997 May; 56(5):526-32. PMID: 9180603.
      View in: PubMed
    122. Edstein MD, Looareesuwan S, Wilairatana P, Vanijanonta S, Kyle DE, Rieckmann KH. Disposition of proguanil in Thai patients with uncomplicated falciparum malaria. Am J Trop Med Hyg. 1997 May; 56(5):498-502. PMID: 9180597.
      View in: PubMed
    123. Obaldia N, Rossan RN, Cooper RD, Kyle DE, Nuzum EO, Rieckmann KH, Shanks GD. WR 238605, chloroquine, and their combinations as blood schizonticides against a chloroquine-resistant strain of Plasmodium vivax in Aotus monkeys. Am J Trop Med Hyg. 1997 May; 56(5):508-10. PMID: 9180599.
      View in: PubMed
    124. Lin AJ, Zikry AB, Kyle DE. Antimalarial activity of new dihydroartemisinin derivatives. 7. 4-(p-substituted phenyl)-4(R or S)-[10(alpha or beta)-dihydroartemisininoxy]butyric acids. J Med Chem. 1997 Apr 25; 40(9):1396-400. PMID: 9135037.
      View in: PubMed
    125. Petras JM, Kyle DE, Gettayacamin M, Young GD, Bauman RA, Webster HK, Corcoran KD, Peggins JO, Vane MA, Brewer TG. Arteether: risks of two-week administration in Macaca mulatta. Am J Trop Med Hyg. 1997 Apr; 56(4):390-6. PMID: 9158046.
      View in: PubMed
    126. Bethell DB, Teja-Isavadharm P, Cao XT, Pham TT, Ta TT, Tran TN, Nguyen TT, Pham TP, Kyle D, Day NP, White NJ. Pharmacokinetics of oral artesunate in children with moderately severe Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg. 1997 Mar-Apr; 91(2):195-8. PMID: 9196768.
      View in: PubMed
    127. Wilairatana P, Kyle DE, Looareesuwan S, Chinwongprom K, Amradee S, White NJ, Watkins WM. Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute, uncomplicated, falciparum malaria in Thailand. Ann Trop Med Parasitol. 1997 Mar; 91(2):125-32. PMID: 9307653.
      View in: PubMed
    128. Pukrittayakamee S, Looareesuwan S, Keeratithakul D, Davis TM, Teja-Isavadharm P, Nagachinta B, Weber A, Smith AL, Kyle D, White NJ. A study of the factors affecting the metabolic clearance of quinine in malaria. Eur J Clin Pharmacol. 1997; 52(6):487-93. PMID: 9342585.
      View in: PubMed
    129. Pattanapanyasat K, Thaithong S, Kyle DE, Udomsangpetch R, Yongvanitchit K, Hider RC, Webster HK. Flow cytometric assessment of hydroxypyridinone iron chelators on in vitro growth of drug-resistant malaria. Cytometry. 1997 Jan 01; 27(1):84-91. PMID: 9000589.
      View in: PubMed
    130. Pattanapanyasat K, Yongvanitchit K, Heppner DG, Tongtawe P, Kyle DE, Webster HK. Culture of malaria parasites in two different red blood cell populations using biotin and flow cytometry. Cytometry. 1996 Nov 01; 25(3):287-94. PMID: 8914826.
      View in: PubMed
    131. Teja-Isavadharm P, Nosten F, Kyle DE, Luxemburger C, Ter Kuile F, Peggins JO, Brewer TG, White NJ. Comparative bioavailability of oral, rectal, and intramuscular artemether in healthy subjects: use of simultaneous measurement by high performance liquid chromatography and bioassay. Br J Clin Pharmacol. 1996 Nov; 42(5):599-604. PMID: 8951191.
      View in: PubMed
    132. Nosten F, Luxemburger C, Kyle DE, Ballou WR, Wittes J, Wah E, Chongsuphajaisiddhi T, Gordon DM, White NJ, Sadoff JC, Heppner DG. Randomised double-blind placebo-controlled trial of SPf66 malaria vaccine in children in northwestern Thailand. Shoklo SPf66 Malaria Vaccine Trial Group. Lancet. 1996 Sep 14; 348(9029):701-7. PMID: 8806288.
      View in: PubMed
    133. Nontprasert A, Pukrittayakamee S, Kyle DE, Vanijanonta S, White NJ. Antimalarial activity and interactions between quinine, dihydroquinine and 3-hydroxyquinine against Plasmodium falciparum in vitro. Trans R Soc Trop Med Hyg. 1996 Sep-Oct; 90(5):553-5. PMID: 8944272.
      View in: PubMed
    134. Edstein MD, Yeo AE, Kyle DE, Looareesuwan S, Wilairatana P, Rieckmann KH. Proguanil polymorphism does not affect the antimalarial activity of proguanil combined with atovaquone in vitro. Trans R Soc Trop Med Hyg. 1996 Jul-Aug; 90(4):418-21. PMID: 8882194.
      View in: PubMed
    135. Edstein MD, Looareesuwan S, Viravan C, Kyle DE. Pharmacokinetics of proguanil in malaria patients treated with proguanil plus atovaquone. Southeast Asian J Trop Med Public Health. 1996 Jun; 27(2):216-20. PMID: 9279980.
      View in: PubMed
    136. Hopperus Buma AP, van Thiel PP, Lobel HO, Ohrt C, van Ameijden EJ, Veltink RL, Tendeloo DC, van Gool T, Green MD, Todd GD, Kyle DE, Kager PA. Long-term malaria chemoprophylaxis with mefloquine in Dutch marines in Cambodia. J Infect Dis. 1996 Jun; 173(6):1506-9. PMID: 8648231.
      View in: PubMed
    137. Looareesuwan S, Olliaro P, Kyle D, Wernsdorfer W. Pyronaridine. Lancet. 1996 Apr 27; 347(9009):1189-90. PMID: 8609791.
      View in: PubMed
    138. Udomsangpetch R, Pipitaporn B, Krishna S, Angus B, Pukrittayakamee S, Bates I, Suputtamongkol Y, Kyle DE, White NJ. Antimalarial drugs reduce cytoadherence and rosetting Plasmodium falciparum. J Infect Dis. 1996 Mar; 173(3):691-8. PMID: 8627034.
      View in: PubMed
    139. Luxemburger C, Thwai KL, White NJ, Webster HK, Kyle DE, Maelankirri L, Chongsuphajaisiddhi T, Nosten F. The epidemiology of malaria in a Karen population on the western border of Thailand. Trans R Soc Trop Med Hyg. 1996 Mar-Apr; 90(2):105-11. PMID: 8761562.
      View in: PubMed
    140. Looareesuwan S, Kyle DE, Viravan C, Vanijanonta S, Wilairatana P, Wernsdorfer WH. Clinical study of pyronaridine for the treatment of acute uncomplicated falciparum malaria in Thailand. Am J Trop Med Hyg. 1996 Feb; 54(2):205-9. PMID: 8619449.
      View in: PubMed
    141. Looareesuwan S, Viravan C, Webster HK, Kyle DE, Hutchinson DB, Canfield CJ. Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand. Am J Trop Med Hyg. 1996 Jan; 54(1):62-6. PMID: 8651372.
      View in: PubMed
    142. Ballou WR, Blood J, Chongsuphajaissidhi T, Gordon DM, Heppner DG, Kyle DE, Luxemburger C, Nosten F, Sadoff JC, Singhasivanon P, et al. Field trials of an asexual blood stage malaria vaccine: studies of the synthetic peptide polymer SPf66 in Thailand and the analytic plan for a phase IIb efficacy study. Parasitology. 1995; 110 Suppl:S25-36. PMID: 7784126.
      View in: PubMed
    143. ter Kuile FO, Nosten F, Luxemburger C, Kyle D, Teja-Isavatharm P, Phaipun L, Price R, Chongsuphajaisiddhi T, White NJ. Mefloquine treatment of acute falciparum malaria: a prospective study of non-serious adverse effects in 3673 patients. Bull World Health Organ. 1995; 73(5):631-42. PMID: 8846489.
      View in: PubMed
    144. Pattanapanyasat K, Kyle DE, Tongtawe P, Yongvanitchit K, Fucharoen S. Flow cytometric immunophenotyping of lymphocyte subsets in samples that contain a high proportion of non-lymphoid cells. Cytometry. 1994 Dec 15; 18(4):199-208. PMID: 7534676.
      View in: PubMed
    145. Gopinath R, Wongsrichanalai C, Cordón-Rosales C, Mirabelli L, Kyle D, Kain KC. Failure to detect a Plasmodium vivax-like malaria parasite in globally collected blood samples. J Infect Dis. 1994 Dec; 170(6):1630-3. PMID: 7996011.
      View in: PubMed
    146. Kain KC, Kyle DE, Wongsrichanalai C, Brown AE, Webster HK, Vanijanonta S, Looareesuwan S. Qualitative and semiquantitative polymerase chain reaction to predict Plasmodium falciparum treatment failure. J Infect Dis. 1994 Dec; 170(6):1626-30. PMID: 7996010.
      View in: PubMed
    147. Looareesuwan S, Viravan C, Vanijanonta S, Wilairatana P, Charoenlarp P, Canfield CJ, Kyle DE. Randomized trial of mefloquine-doxycycline, and artesunate-doxycycline for treatment of acute uncomplicated falciparum malaria. Am J Trop Med Hyg. 1994 Jun; 50(6):784-9. PMID: 8024075.
      View in: PubMed
    148. Looareesuwan S, Vanijanonta S, Viravan C, Wilairatana P, Charoenlarp P, Lasserre R, Canfield C, Kyle DE, Webster HK. Randomised trial of mefloquine-tetracycline and quinine-tetracycline for acute uncomplicated falciparum malaria. Acta Trop. 1994 Jun; 57(1):47-53. PMID: 7942354.
      View in: PubMed
    149. Maeno Y, Brown AE, Smith CD, Tegoshi T, Toyoshima T, Ockenhouse CF, Corcoran KD, Ngampochjana M, Kyle DE, Webster HK, et al. A nonhuman primate model for human cerebral malaria: effects of artesunate (qinghaosu derivative) on rhesus monkeys experimentally infected with Plasmodium coatneyi. Am J Trop Med Hyg. 1993 Dec; 49(6):726-34. PMID: 7506497.
      View in: PubMed
    150. Krishna S, ter Kuile F, Supanaranond W, Pukrittayakamee S, Teja-Isavadharm P, Kyle D, White NJ. Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria. Br J Clin Pharmacol. 1993 Dec; 36(6):585-91. PMID: 12959277.
      View in: PubMed
    151. Looareesuwan S, Viravan C, Vanijanonta S, Wilairatana P, Charoenlarp P, Canfield C, Kyle DE. Treatment of acute uncomplicated falciparum malaria with a short course of artesunate followed by mefloquine. Southeast Asian J Trop Med Public Health. 1993 Jun; 24(2):230-4. PMID: 8266223.
      View in: PubMed
    152. Nosten F, ter Kuile FO, Luxemburger C, Woodrow C, Kyle DE, Chongsuphajaisiddhi T, White NJ. Cardiac effects of antimalarial treatment with halofantrine. Lancet. 1993 Apr 24; 341(8852):1054-6. PMID: 8096959.
      View in: PubMed
    153. Shmuklarsky MJ, Klayman DL, Milhous WK, Kyle DE, Rossan RN, Ager AL, Tang DB, Heiffer MH, Canfield CJ, Schuster BG. Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo. Am J Trop Med Hyg. 1993 Mar; 48(3):377-84. PMID: 8470775.
      View in: PubMed
    154. Oduola AM, Omitowoju GO, Gerena L, Kyle DE, Milhous WK, Sowunmi A, Salako LA. Reversal of mefloquine resistance with penfluridol in isolates of Plasmodium falciparum from south-west Nigeria. Trans R Soc Trop Med Hyg. 1993 Jan-Feb; 87(1):81-3. PMID: 8465407.
      View in: PubMed
    155. Wilson CM, Volkman SK, Thaithong S, Martin RK, Kyle DE, Milhous WK, Wirth DF. Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand. Mol Biochem Parasitol. 1993 Jan; 57(1):151-60. PMID: 8426608.
      View in: PubMed
    156. Kyle DE, Milhous WK, Rossan RN. Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys. Am J Trop Med Hyg. 1993 Jan; 48(1):126-33. PMID: 8427381.
      View in: PubMed
    157. Gerena L, Bass GT, Kyle DE, Oduola AM, Milhous WK, Martin RK. Fluoxetine hydrochloride enhances in vitro susceptibility to chloroquine in resistant Plasmodium falciparum. Antimicrob Agents Chemother. 1992 Dec; 36(12):2761-5. PMID: 1482144.
      View in: PubMed
    158. Looareesuwan S, Kyle DE, Viravan C, Vanijanonta S, Wilairatana P, Charoenlarp P, Canfield CJ, Webster HK. Treatment of patients with recrudescent falciparum malaria with a sequential combination of artesunate and mefloquine. Am J Trop Med Hyg. 1992 Dec; 47(6):794-9. PMID: 1471736.
      View in: PubMed
    159. Wongsrichanalai C, Namsiripongpun V, Pornsilapatip J, Kyle DE, Wilde H. Sensitivity of QBC malaria test. Lancet. 1992 Sep 26; 340(8822):792-3. PMID: 1356201.
      View in: PubMed
    160. Looareesuwan S, Viravan C, Vanijanonta S, Wilairatana P, Suntharasamai P, Charoenlarp P, Arnold K, Kyle D, Canfield C, Webster K. Randomised trial of artesunate and mefloquine alone and in sequence for acute uncomplicated falciparum malaria. Lancet. 1992 Apr 04; 339(8797):821-4. PMID: 1347854.
      View in: PubMed
    161. Oduola AM, Sowunmi A, Milhous WK, Kyle DE, Martin RK, Walker O, Salako LA. Innate resistance to new antimalarial drugs in Plasmodium falciparum from Nigeria. Trans R Soc Trop Med Hyg. 1992 Mar-Apr; 86(2):123-6. PMID: 1440764.
      View in: PubMed
    162. Looareesuwan S, Wilairatana P, Vanijanonta S, Kyle D, Webster K. Efficacy of quinine-tetracycline for acute uncomplicated falciparum malaria in Thailand. Lancet. 1992 Feb 08; 339(8789):369. PMID: 1346445.
      View in: PubMed
    163. Grogl M, Martin RK, Oduola AM, Milhous WK, Kyle DE. Characteristics of multidrug resistance in Plasmodium and Leishmania: detection of P-glycoprotein-like components. Am J Trop Med Hyg. 1991 Jul; 45(1):98-111. PMID: 1678253.
      View in: PubMed
    164. Kyle DE, Oduola AM, Martin SK, Milhous WK. Plasmodium falciparum: modulation by calcium antagonists of resistance to chloroquine, desethylchloroquine, quinine, and quinidine in vitro. Trans R Soc Trop Med Hyg. 1990 Jul-Aug; 84(4):474-8. PMID: 2091331.
      View in: PubMed
    165. Bell CA, Hall JE, Kyle DE, Grogl M, Ohemeng KA, Allen MA, Tidwell RR. Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis. Antimicrob Agents Chemother. 1990 Jul; 34(7):1381-6. PMID: 2201254.
      View in: PubMed
    166. Foote SJ, Kyle DE, Martin RK, Oduola AM, Forsyth K, Kemp DJ, Cowman AF. Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum. Nature. 1990 May 17; 345(6272):255-8. PMID: 2185424.
      View in: PubMed
    167. Grögl M, Oduola AM, Cordero LD, Kyle DE. Leishmania spp.: development of pentostam-resistant clones in vitro by discontinuous drug exposure. Exp Parasitol. 1989 Jul; 69(1):78-90. PMID: 2543590.
      View in: PubMed
    168. Monson MH, Kyle DE, Oduola AM, Broadbent P. Multiple drug resistance of Plasmodium falciparum in Liberia. Trans R Soc Trop Med Hyg. 1989 May-Jun; 83(3):311-2. PMID: 2694462.
      View in: PubMed
    169. Oduola AM, Moyou-Somo RS, Kyle DE, Martin SK, Gerena L, Milhous WK. Chloroquine resistant Plasmodium falciparum in indigenous residents of Cameroon. Trans R Soc Trop Med Hyg. 1989 May-Jun; 83(3):308-10. PMID: 2694461.
      View in: PubMed
    170. Milhous WK, Gerena L, Kyle DE, Oduola AM. In vitro strategies for circumventing antimalarial drug resistance. Prog Clin Biol Res. 1989; 313:61-72. PMID: 2675118.
      View in: PubMed
    171. Bitonti AJ, Sjoerdsma A, McCann PP, Kyle DE, Oduola AM, Rossan RN, Milhous WK, Davidson DE. Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine. Science. 1988 Dec 02; 242(4883):1301-3. PMID: 3057629.
      View in: PubMed
    172. Jacobs GH, Oduola AM, Kyle DE, Milhous WK, Martin SK, Aikawa M. Ultrastructural study of the effects of chloroquine and verapamil on Plasmodium falciparum. Am J Trop Med Hyg. 1988 Jul; 39(1):15-20. PMID: 3041853.
      View in: PubMed
    173. Krogstad DJ, Gluzman IY, Kyle DE, Oduola AM, Martin SK, Milhous WK, Schlesinger PH. Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance. Science. 1987 Nov 27; 238(4831):1283-5. PMID: 3317830.
      View in: PubMed
    Kyle's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description