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Dr Corinne Merle

TitleScientist
InstitutionWHO TDR
DepartmentImplementation and intervention Research Unit
AddressGeneva
Switzerland
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    Collapse Overview 
    Collapse overview
    Doctor of the faculty of Medicine of Reims University (France) with a specialization in infectious diseases and in Public Health. I also hold a Master of Epidemiology and Statistics (Nancy, France) and a Master of Economic & Health Policy (Paris Sorbonne, France). I have been working in the field of infectious disease research for almost 20 years. I have been involved in various types of Public Health and research projects conducted in different Low and Middle Income countries. I spent 10 years at the London School of Hygiene and Tropical Medicine where my research areas were mainly Tuberculosis, HIV and Malaria. Since October 2014, I joined the Special Programme for research and training in tropical diseases (TDR) of the WHO were I focus more my research activities in poverty related diseases implementation research.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Halpaap B, Vahedi M, Certain E, Alvarado T, Saint Martin C, Merle C, Mihut M, Launois P. Tracking the career development of scientists in low- and middle-income countries trained through TDR's research capacity strengthening programmes: Learning from monitoring and impact evaluation. PLoS Negl Trop Dis. 2017 Dec; 11(12):e0006112. PMID: 29216192.
      View in: PubMed
    2. Mahendradhata Y, Nabieva J, Ahmad RA, Henley P, Launois P, Merle C, Maure C, Horstick O, Elango V. Promoting good health research practice in low- and middle-income countries. Glob Health Action. 2016; 9:32474. PMID: 27498965.
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    3. Mijiti P, Yuehua L, Feng X, Milligan PJ, Merle C, Gang W, Nianqiang L, Upur H. Prevalence of pulmonary tuberculosis in western China in 2010-11: a population-based, cross-sectional survey. Lancet Glob Health. 2016 07; 4(7):e485-94. PMID: 27283762.
      View in: PubMed
    4. Stagg HR, Abubakar I, Brown J, Lalor MK, Thomas HL, Mohiyuddin T, Pedrazzoli D, Merle CS. Towards better guidance on caseload thresholds to promote positive tuberculosis treatment outcomes: a cohort study. BMC Med. 2016 Mar 23; 14:52. PMID: 27004514.
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    5. Furin J, Alirol E, Allen E, Fielding K, Merle C, Abubakar I, Andersen J, Davies G, Dheda K, Diacon A, Dooley KE, Dravnice G, Eisenach K, Everitt D, Ferstenberg D, Goolam-Mahomed A, Grobusch MP, Gupta R, Harausz E, Harrington M, Horsburgh CR, Lienhardt C, McNeeley D, Mitnick CD, Nachman S, Nahid P, Nunn AJ, Phillips P, Rodriguez C, Shah S, Wells C, Thomas-Nyang'wa B, du Cros P. Drug-resistant tuberculosis clinical trials: proposed core research definitions in adults. Int J Tuberc Lung Dis. 2016 Mar; 20(3):290-4. PMID: 27046707.
      View in: PubMed
    6. Ejo M, Gehre F, Barry MD, Sow O, Bah NM, Camara M, Bah B, Uwizeye C, Nduwamahoro E, Fissette K, De Rijk P, Merle C, Olliaro P, Burgos M, Lienhardt C, Rigouts L, de Jong BC. First insights into circulating Mycobacterium tuberculosis complex lineages and drug resistance in Guinea. Infect Genet Evol. 2015 Jul; 33:314-9. PMID: 26004194.
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    7. Gehre F, Ejo M, Fissette K, de Rijk P, Uwizeye C, Nduwamahoro E, Goovaerts O, Affolabi D, Gninafon M, Lingoupou FM, Barry MD, Sow O, Merle C, Olliaro P, Ba F, Sarr M, Piubello A, Noeske J, Antonio M, Rigouts L, de Jong BC. Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa. PLoS One. 2014; 9(12):e110393. PMID: 25493429.
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    8. Merle CS, Fielding K, Sow OB, Gninafon M, Lo MB, Mthiyane T, Odhiambo J, Amukoye E, Bah B, Kassa F, N'Diaye A, Rustomjee R, de Jong BC, Horton J, Perronne C, Sismanidis C, Lapujade O, Olliaro PL, Lienhardt C. A four-month gatifloxacin-containing regimen for treating tuberculosis. N Engl J Med. 2014 Oct 23; 371(17):1588-98. PMID: 25337748.
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    9. Research capacity. Enabling the genomic revolution in Africa. Science. 2014 Jun 20; 344(6190):1346-8. PMID: 24948725.
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    10. Xiang Y, Ma L, Wu W, Liu W, Li Y, Zhu X, Wang Q, Ma J, Cao M, Wang Q, Yao X, Yang L, Wubuli A, Merle C, Milligan P, Mao Y, Gu J, Xin X. The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1. PLoS One. 2014; 9(1):e85905. PMID: 24465778.
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    11. Russell GK, Merle CS, Cooke GS, Casas EC, Silveira da Fonseca M, du Cros P. Towards the WHO target of zero childhood tuberculosis deaths: an analysis of mortality in 13 locations in Africa and Asia. Int J Tuberc Lung Dis. 2013 Dec; 17(12):1518-23. PMID: 24200262.
      View in: PubMed
    12. Smythe W, Merle CS, Rustomjee R, Gninafon M, Lo MB, Bah-Sow O, Olliaro PL, Lienhardt C, Horton J, Smith P, McIlleron H, Simonsson US. Evaluation of initial and steady-state gatifloxacin pharmacokinetics and dose in pulmonary tuberculosis patients by using monte carlo simulations. Antimicrob Agents Chemother. 2013 Sep; 57(9):4164-71. PMID: 23774436.
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    13. Merle CS, Sismanidis C, Sow OB, Gninafon M, Horton J, Lapujade O, Lo MB, Mitchinson DA, Perronne C, Portaels F, Odhiambo J, Olliaro P, Rustomjee R, Lienhardt C, Fielding K. A pivotal registration phase III, multicenter, randomized tuberculosis controlled trial: design issues and lessons learnt from the Gatifloxacin for TB (OFLOTUB) project. Trials. 2012 May 18; 13:61. PMID: 22607233.
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    14. Smythe W, Khandelwal A, Merle C, Rustomjee R, Gninafon M, Bocar Lo M, Sow OB, Olliaro PL, Lienhardt C, Horton J, Smith P, McIlleron H, Simonsson US. A semimechanistic pharmacokinetic-enzyme turnover model for rifampin autoinduction in adult tuberculosis patients. Antimicrob Agents Chemother. 2012 Apr; 56(4):2091-8. PMID: 22252827.
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    15. Merle CS, Cunha SS, Rodrigues LC. BCG vaccination and leprosy protection: review of current evidence and status of BCG in leprosy control. Expert Rev Vaccines. 2010 Feb; 9(2):209-22. PMID: 20109030.
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    16. Salomon J, Denys P, Merle C, Chartier-Kastler E, Perronne C, Gaillard JL, Bernard L. Prevention of urinary tract infection in spinal cord-injured patients: safety and efficacy of a weekly oral cyclic antibiotic (WOCA) programme with a 2 year follow-up--an observational prospective study. J Antimicrob Chemother. 2006 Apr; 57(4):784-8. PMID: 16473921.
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    17. Legout L, Stern R, Assal M, Rohner P, Merle C, Hoffmeyer P, Bernard L. Suction drainage culture as a guide to effectively treat musculoskeletal infection. Scand J Infect Dis. 2006; 38(5):341-5. PMID: 16709535.
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    18. Bernard L, Vaudaux P, Merle C, Stern R, Huggler E, Lew D, Hoffmeyer P. The inhibition of neutrophil antibacterial activity by ultra-high molecular weight polyethylene particles. Biomaterials. 2005 Sep; 26(27):5552-7. PMID: 15860211.
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    19. Galpérine T, Merle C, de Truchis P, Bernard L, Perronne C. [Intolerance to and/or drug interactions of anti-HIV and anti-HVC therapy]. Med Mal Infect. 2005 Mar; 35(3):135-40. PMID: 15911183.
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    20. Merle C, Lepouse C, De Garine A, Frayssinet N, Leymarie F, Leon A, Jolly D. Surgery for mesenteric infarction: prognostic factors associated with early death within 72 hours. J Cardiothorac Vasc Anesth. 2004 Dec; 18(6):734-41. PMID: 15650983.
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    21. Lévy-Bohbot N, Merle C, Goudet P, Delemer B, Calender A, Jolly D, Thiéfin G, Cadiot G. Prevalence, characteristics and prognosis of MEN 1-associated glucagonomas, VIPomas, and somatostatinomas: study from the GTE (Groupe des Tumeurs Endocrines) registry. Gastroenterol Clin Biol. 2004 Nov; 28(11):1075-81. PMID: 15657529.
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    22. Diebold MD, Samalin E, Merle C, Bouché O, Higuero T, Jolly D, Ramaholimihaso F, Renard P, Yaziji N, Thiéfin G, Cadiot G. Colonic flat neoplasia: frequency and concordance between endoscopic appearance and histological diagnosis in a French prospective series. Am J Gastroenterol. 2004 Sep; 99(9):1795-800. PMID: 15330921.
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    23. Barré P, Merle C, Conessa C, Desgeorges M, Poncet JL. [Postoperative quality of life for patients with a vestibular schwannoma]. Ann Otolaryngol Chir Cervicofac. 2004 Apr; 121(2):83-94. PMID: 15107734.
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    24. Higuero T, Merle C, Thiéfin G, Coussinet S, Jolly D, Diebold MD, Zeitoun P, Cadiot G. Jejunoileal Crohn's disease: a case-control study. Gastroenterol Clin Biol. 2004 Feb; 28(2):160-6. PMID: 15060461.
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    25. Derancourt C, Merle C, Godeau H, Vignon F, Lemoussu C, Verraes Derancourt S, Bernard P. [Clinical assessment of the risk of Human Immunodeficiency virus (HIV) infection in the population consulting an anonymous and free screening center]. Ann Dermatol Venereol. 2004 Jan; 131(1 Pt 1):11-5. PMID: 15041838.
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    26. Deschamps F, Paganon-Badinier I, Marchand AC, Merle C. Sources and assessment of occupational stress in the police. J Occup Health. 2003 Nov; 45(6):358-64. PMID: 14676415.
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    27. Alaoui M, Merle C, Garnotel R, Jolly D, Durlach V, Gillery P. Study of apo(a) length polymorphism and lipoprotein(a) concentrations in subjects with single or double apo(a) isoforms. Clin Chem Lab Med. 2003 May; 41(5):634-9. PMID: 12812260.
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    28. Piednoir E, Bureau-Chalot F, Merle C, Gotzamanis A, Wuibout J, Bajolet O. Direct costs associated with a nosocomial outbreak of adenoviral conjunctivitis infection in a long-term care institution. Am J Infect Control. 2002 Nov; 30(7):407-10. PMID: 12410217.
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    29. Nguyen TD, Mallet F, Petit M, Lemaire P, Cauchois A, Loirette M, Merle C. [Non-metastatic prostate cancer treated with exclusive radiotherapy: prognosis of patients according to lymph node radiologic or surgical assessment method. Multivariate retrospective analysis]. Ann Urol (Paris). 2002 May; 36(3):182-9. PMID: 12056091.
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    30. Costa ND, Cadiot G, Merle C, Jolly D, Bouche O, Thiéfin G, Zeitoun P. Bleeding reflux esophagitis: a prospective 1-year study in a university hospital. Am J Gastroenterol. 2001 Jan; 96(1):47-51. PMID: 11197286.
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    31. Koeck JL, Merle C, Bimet F, Kiredjian M, Goullin B, Teyssou R. [First confirmed case of laryngeal diphtheria in Djibouti]. Med Trop (Mars). 2000; 60(3):273-4. PMID: 11258062.
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    32. Koeck JL, Modica C, Tual F, Czarnecki E, Fabre R, Merle C, Montfort F, Jouvenin N, Cavallo JD. [Discovery of a focus of intestinal bilharziasis in te Republic of Djibouti]. Med Trop (Mars). 1999; 59(1):35-8. PMID: 10472579.
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