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Professor Shamala Devi Sekaran

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jindal HM, Ramanathan B, Le CF, Gudimella R, Razali R, Manikam R, Sekaran SD. Comparative genomic analysis of ten clinical Streptococcus pneumoniae collected from a Malaysian hospital reveal 31 new unique drug-resistant SNPs using whole genome sequencing. J Biomed Sci. 2018 Feb 15; 25(1):15. PMID: 29448938.
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    2. Lee SH, Jaganath IB, Atiya N, Manikam R, Sekaran SD. Suppression of ERK1/2 and hypoxia pathways by four Phyllanthus species inhibits metastasis of human breast cancer cells. J Food Drug Anal. 2016 10; 24(4):855-865. PMID: 28911625.
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    3. Wong WR, Sekaran SD, Mahamd Adikan FR, Berini P. Detection of dengue NS1 antigen using long-range surface plasmon waveguides. Biosens Bioelectron. 2016 Apr 15; 78:132-139. PMID: 26599483.
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    4. Akter R, Vythilingam I, Khaw LT, Qvist R, Lim YA, Sitam FT, Venugopalan B, Sekaran SD. Simian malaria in wild macaques: first report from Hulu Selangor district, Selangor, Malaysia. Malar J. 2015 Oct 05; 14:386. PMID: 26437652.
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    5. Lau SM, Vythilingam I, Doss JI, Sekaran SD, Chua TH, Wan Sulaiman WY, Chinna K, Lim YA, Venugopalan B. Surveillance of adult Aedes mosquitoes in Selangor, Malaysia. Trop Med Int Health. 2015 Oct; 20(10):1271-80. PMID: 26094839.
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    6. Le CF, Yusof MY, Hassan MA, Lee VS, Isa DM, Sekaran SD. In vivo efficacy and molecular docking of designed peptide that exhibits potent antipneumococcal activity and synergises in combination with penicillin. Sci Rep. 2015 Jul 09; 5:11886. PMID: 26156658.
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    7. Jindal HM, Le CF, Mohd Yusof MY, Velayuthan RD, Lee VS, Zain SM, Isa DM, Sekaran SD. Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae. PLoS One. 2015; 10(6):e0128532. PMID: 26046345.
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    8. Lum LC, Syed Omar SF, Sri La Sri Ponnampalavanar S, Tan LH, Sekaran SD, Kamarulzaman A. Cohorting Dengue Patients Improves the Quality of Care and Clinical Outcome. PLoS Negl Trop Dis. 2015 Jun; 9(6):e0003836. PMID: 26047325.
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    9. Saeidi A, Chong YK, Yong YK, Tan HY, Barathan M, Rajarajeswaran J, Sabet NS, Sekaran SD, Ponnampalavanar S, Che KF, Velu V, Kamarulzaman A, Larsson M, Shankar EM. Concurrent loss of co-stimulatory molecules and functional cytokine secretion attributes leads to proliferative senescence of CD8(+) T cells in HIV/TB co-infection. Cell Immunol. 2015 Sep; 297(1):19-32. PMID: 26071876.
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    10. Tang YQ, Jaganath IB, Manikam R, Sekaran SD. Phyllanthus spp. Exerts Anti-Angiogenic and Anti-Metastatic Effects Through Inhibition on Matrix Metalloproteinase Enzymes. Nutr Cancer. 2015; 67(5):783-95. PMID: 25996262.
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    11. Le CF, Yusof MY, Hassan H, Sekaran SD. In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin. Sci Rep. 2015 May 18; 5:9761. PMID: 25985150.
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    12. Lum KY, Tay ST, Le CF, Lee VS, Sabri NH, Velayuthan RD, Hassan H, Sekaran SD. Activity of Novel Synthetic Peptides against Candida albicans. Sci Rep. 2015 May 12; 5:9657. PMID: 25965506.
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    13. Vemuri RC, Gundamaraju R, Sekaran SD, Manikam R. Major pathophysiological correlations of rosacea: a complete clinical appraisal. Int J Med Sci. 2015; 12(5):387-96. PMID: 26005373.
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    14. Jahanshahi P, Sekaran SD, Adikan FR. Optical and analytical investigations on dengue virus rapid diagnostic test for IgM antibody detection. Med Biol Eng Comput. 2015 Aug; 53(8):679-87. PMID: 25791696.
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    15. Yeo AS, Rathakrishnan A, Wang SM, Ponnampalavanar S, Manikam R, Sathar J, Kumari Natkunam S, Sekaran SD. Dengue patients exhibit higher levels of PrM and E antibodies than their asymptomatic counterparts. Biomed Res Int. 2015; 2015:420867. PMID: 25815314.
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    16. Gundamaraju R, Singla RK, Vemuri RC, Sekaran SD. Functional correlation of medicinal chemistry and Entamoeba histolytica treatment: an emphasis on the past, present and future chemotherapy. Mini Rev Med Chem. 2015; 15(3):211-9. PMID: 25769970.
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    17. Hunsperger EA, Yoksan S, Buchy P, Nguyen VC, Sekaran SD, Enria DA, Vazquez S, Cartozian E, Pelegrino JL, Artsob H, Guzman MG, Olliaro P, Zwang J, Guillerm M, Kliks S, Halstead S, Peeling RW, Margolis HS. Evaluation of commercially available diagnostic tests for the detection of dengue virus NS1 antigen and anti-dengue virus IgM antibody. PLoS Negl Trop Dis. 2014 Oct; 8(10):e3171. PMID: 25330157.
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    18. Gundamaraju R, Vemuri RC, Singla RK, Manikam R, Rao AR, Sekaran SD. Strophanthus hispidus attenuates the Ischemia-Reperfusion induced myocardial Infarction and reduces mean arterial pressure in renal artery occlusion. Pharmacogn Mag. 2014 Aug; 10(Suppl 3):S557-62. PMID: 25298674.
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    19. Kassim M, Mansor M, Kamalden TA, Shariffuddin II, Hasan MS, Ong G, Sekaran SD, Suhaimi A, Al-Abd N, Yusoff KM. Caffeic acid phenethyl ester (CAPE): scavenger of peroxynitrite in vitro and in sepsis models. Shock. 2014 Aug; 42(2):154-60. PMID: 24667629.
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    20. Tang YQ, Jaganath IB, Manikam R, Sekaran SD. Inhibition of MAPKs, Myc/Max, NF?B, and hypoxia pathways by Phyllanthus prevents proliferation, metastasis and angiogenesis in human melanoma (MeWo) cancer cell line. Int J Med Sci. 2014; 11(6):564-77. PMID: 24782645.
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    21. Farooq SM, Boppana NB, Devarajan A, Asokan D, Sekaran SD, Shankar EM, Li C, Gopal K, Bakar SA, Karthik HS, Ebrahim AS. C-phycocyanin confers protection against oxalate-mediated oxidative stress and mitochondrial dysfunctions in MDCK cells. PLoS One. 2014; 9(4):e93056. PMID: 24691130.
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    22. Rathakrishnan A, Klekamp B, Wang SM, Komarasamy TV, Natkunam SK, Sathar J, Azizan A, Sanchez-Anguiano A, Manikam R, Sekaran SD. Clinical and immunological markers of dengue progression in a study cohort from a hyperendemic area in Malaysia. PLoS One. 2014; 9(3):e92021. PMID: 24647042.
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    23. Leow SS, Sekaran SD, Sundram K, Tan Y, Sambanthamurthi R. Gene expression changes in spleens and livers of tumour-bearing mice suggest delayed inflammation and attenuated cachexia in response to oil palm phenolics. J Nutrigenet Nutrigenomics. 2013; 6(6):305-26. PMID: 24642698.
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    24. Jahanshahi P, Zalnezhad E, Sekaran SD, Adikan FR. Rapid immunoglobulin M-based dengue diagnostic test using surface plasmon resonance biosensor. Sci Rep. 2014 Jan 24; 4:3851. PMID: 24458089.
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    25. Wong WR, Krupin O, Sekaran SD, Mahamd Adikan FR, Berini P. Serological diagnosis of dengue infection in blood plasma using long-range surface plasmon waveguides. Anal Chem. 2014 Feb 04; 86(3):1735-43. PMID: 24410440.
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    26. Tan WC, Jaganath IB, Manikam R, Sekaran SD. Evaluation of antiviral activities of four local Malaysian Phyllanthus species against herpes simplex viruses and possible antiviral target. Int J Med Sci. 2013; 10(13):1817-29. PMID: 24324358.
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    27. Lee SH, Jaganath IB, Manikam R, Sekaran SD. Inhibition of Raf-MEK-ERK and hypoxia pathways by Phyllanthus prevents metastasis in human lung (A549) cancer cell line. BMC Complement Altern Med. 2013 Oct 20; 13:271. PMID: 24138815.
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    28. Lee SH, Tang YQ, Rathkrishnan A, Wang SM, Ong KC, Manikam R, Payne BJ, Jaganath IB, Sekaran SD. Effects of cocktail of four local Malaysian medicinal plants (Phyllanthus spp.) against dengue virus 2. BMC Complement Altern Med. 2013 Jul 26; 13:192. PMID: 23889893.
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    29. Alhoot MA, Rathinam AK, Wang SM, Manikam R, Sekaran SD. Inhibition of dengue virus entry into target cells using synthetic antiviral peptides. Int J Med Sci. 2013; 10(6):719-29. PMID: 23630436.
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    30. Tang YQ, Jaganath I, Manikam R, Sekaran SD. Phyllanthus Suppresses Prostate Cancer Cell, PC-3, Proliferation and Induces Apoptosis through Multiple Signalling Pathways (MAPKs, PI3K/Akt, NF?B, and Hypoxia). Evid Based Complement Alternat Med. 2013; 2013:609581. PMID: 23690850.
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    31. Batumalaie K, Qvist R, Yusof KM, Ismail IS, Sekaran SD. The antioxidant effect of the Malaysian Gelam honey on pancreatic hamster cells cultured under hyperglycemic conditions. Clin Exp Med. 2014 May; 14(2):185-95. PMID: 23584372.
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    32. Leow SS, Sekaran SD, Tan Y, Sundram K, Sambanthamurthi R. Oil palm phenolics confer neuroprotective effects involving cognitive and motor functions in mice. Nutr Neurosci. 2013 Sep; 16(5):207-17. PMID: 23433062.
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    33. Rathakrishnan A, Wang SM, Hu Y, Khan AM, Ponnampalavanar S, Lum LC, Manikam R, Sekaran SD. Cytokine expression profile of dengue patients at different phases of illness. PLoS One. 2012; 7(12):e52215. PMID: 23284941.
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    34. Appanna R, Wang SM, Ponnampalavanar SA, Lum LC, Sekaran SD. Cytokine factors present in dengue patient sera induces alterations of junctional proteins in human endothelial cells. Am J Trop Med Hyg. 2012 Nov; 87(5):936-42. PMID: 22987650.
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    35. Rathakrishnan A, Sekaran SD. New development in the diagnosis of dengue infections. Expert Opin Med Diagn. 2013 Jan; 7(1):99-112. PMID: 23530846.
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    36. Anbazhagan D, Mansor M, Yan GO, Md Yusof MY, Hassan H, Sekaran SD. Detection of quorum sensing signal molecules and identification of an autoinducer synthase gene among biofilm forming clinical isolates of Acinetobacter spp. PLoS One. 2012; 7(7):e36696. PMID: 22815678.
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    37. Le CF, Jefferies JM, Yusof MY, Sekaran SD, Clarke SC. The epidemiology of pneumococcal carriage and infections in Malaysia. Expert Rev Anti Infect Ther. 2012 Jun; 10(6):707-19. PMID: 22734960.
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    38. Kassim M, Yusoff KM, Ong G, Sekaran S, Yusof MY, Mansor M. Gelam honey inhibits lipopolysaccharide-induced endotoxemia in rats through the induction of heme oxygenase-1 and the inhibition of cytokines, nitric oxide, and high-mobility group protein B1. Fitoterapia. 2012 Sep; 83(6):1054-9. PMID: 22626749.
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    39. Tan PC, Soe MZ, Si Lay K, Wang SM, Sekaran SD, Omar SZ. Dengue infection and miscarriage: a prospective case control study. PLoS Negl Trop Dis. 2012; 6(5):e1637. PMID: 22590658.
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    40. Leow SS, Sekaran SD, Sundram K, Tan Y, Sambanthamurthi R. Oil palm phenolics attenuate changes caused by an atherogenic diet in mice. Eur J Nutr. 2013 Mar; 52(2):443-56. PMID: 22527284.
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    41. Alhoot MA, Wang SM, Sekaran SD. RNA interference mediated inhibition of dengue virus multiplication and entry in HepG2 cells. PLoS One. 2012; 7(3):e34060. PMID: 22457813.
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    42. Komarasamy TV, Sekaran SD. The anti-proliferative effects of a palm oil-derived product and its mode of actions in human malignant melanoma MeWo cells. J Oleo Sci. 2012; 61(4):227-39. PMID: 22450124.
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    43. Alhoot MA, Wang SM, Sekaran SD. Inhibition of dengue virus entry and multiplication into monocytes using RNA interference. PLoS Negl Trop Dis. 2011 Nov; 5(11):e1410. PMID: 22140591.
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    44. Leow SS, Sekaran SD, Sundram K, Tan Y, Sambanthamurthi R. Differential transcriptomic profiles effected by oil palm phenolics indicate novel health outcomes. BMC Genomics. 2011 Aug 25; 12:432. PMID: 21864415.
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    45. Lek Yap S, Sekaran SD, Soong TK, Nga AD, Subrayan V. PCR analysis of aqueous in cataract surgery. Ophthalmology. 2011 Aug; 118(8):1688. PMID: 21813092.
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    46. Tan YY, Sekaran SD, Wang SM, Ahmed F, Hossain A, Sil BK. Development of ASSURE Dengue IgA Rapid Test for the Detection of Anti-dengue IgA from Dengue Infected Patients. J Glob Infect Dis. 2011 Jul; 3(3):233-40. PMID: 21887054.
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    47. Fry SR, Meyer M, Semple MG, Simmons CP, Sekaran SD, Huang JX, McElnea C, Huang CY, Valks A, Young PR, Cooper MA. The diagnostic sensitivity of dengue rapid test assays is significantly enhanced by using a combined antigen and antibody testing approach. PLoS Negl Trop Dis. 2011 Jun; 5(6):e1199. PMID: 21713023.
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    48. Lee SH, Jaganath IB, Wang SM, Sekaran SD. Antimetastatic effects of Phyllanthus on human lung (A549) and breast (MCF-7) cancer cell lines. PLoS One. 2011; 6(6):e20994. PMID: 21698198.
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    49. Sambanthamurthi R, Tan Y, Sundram K, Hayes KC, Abeywardena M, Leow SS, Sekaran SD, Sambandan TG, Rha C, Sinskey AJ, Subramaniam K, Fairus S, Wahid MB. Positive outcomes of oil palm phenolics on degenerative diseases in animal models. Br J Nutr. 2011 Dec; 106(11):1664-75. PMID: 21736778.
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    50. Anbazhagan D, Mui WS, Mansor M, Yan GO, Yusof MY, Sekaran SD. Development of conventional and real-time multiplex PCR assays for the detection of nosocomial pathogens. Braz J Microbiol. 2011 Apr; 42(2):448-58. PMID: 24031653.
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    51. Le CF, Palanisamy NK, Mohd Yusof MY, Sekaran SD. Capsular serotype and antibiotic resistance of Streptococcus pneumoniae isolates in Malaysia. PLoS One. 2011; 6(5):e19547. PMID: 21603602.
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    52. Tan HY, Nagoor NH, Sekaran SD. Cloning, expression and protective capacity of 37 kDa outer membrane protein gene (ompH) of Pasteurella multocida serotype B:2. Trop Biomed. 2010 Dec; 27(3):430-41. PMID: 21399583.
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    53. Lee ML, Tan NH, Fung SY, Sekaran SD. Antibacterial action of a heat-stable form of L-amino acid oxidase isolated from king cobra (Ophiophagus hannah) venom. Comp Biochem Physiol C Toxicol Pharmacol. 2011 Mar; 153(2):237-42. PMID: 21059402.
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    54. Ahmed F, Mursalin H, Alam MT, Amin R, Sekaran SD, Wang SM, Tan YY, Sil BK, Hossain MA. Evaluation of ASSURE® Dengue IgA Rapid Test using dengue-positive and dengue-negative samples. Diagn Microbiol Infect Dis. 2010 Dec; 68(4):339-44. PMID: 20884152.
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    55. Appanna R, Ponnampalavanar S, Lum Chai See L, Sekaran SD. Susceptible and protective HLA class 1 alleles against dengue fever and dengue hemorrhagic fever patients in a Malaysian population. PLoS One. 2010 Sep 28; 5(9). PMID: 20927388.
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    56. Tang YQ, Jaganath IB, Sekaran SD. Phyllanthus spp. induces selective growth inhibition of PC-3 and MeWo human cancer cells through modulation of cell cycle and induction of apoptosis. PLoS One. 2010 Sep 08; 5(9):e12644. PMID: 20838625.
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    57. Wang SM, Sekaran SD. Early diagnosis of Dengue infection using a commercial Dengue Duo rapid test kit for the detection of NS1, IGM, and IGG. Am J Trop Med Hyg. 2010 Sep; 83(3):690-5. PMID: 20810840.
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    58. Guzman MG, Jaenisch T, Gaczkowski R, Ty Hang VT, Sekaran SD, Kroeger A, Vazquez S, Ruiz D, Martinez E, Mercado JC, Balmaseda A, Harris E, Dimano E, Leano PS, Yoksan S, Villegas E, Benduzu H, Villalobos I, Farrar J, Simmons CP. Multi-country evaluation of the sensitivity and specificity of two commercially-available NS1 ELISA assays for dengue diagnosis. PLoS Negl Trop Dis. 2010 Aug 31; 4(8). PMID: 20824173.
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    59. Wang SM, Sekaran SD. Evaluation of a commercial SD dengue virus NS1 antigen capture enzyme-linked immunosorbent assay kit for early diagnosis of dengue virus infection. J Clin Microbiol. 2010 Aug; 48(8):2793-7. PMID: 20573879.
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    60. Wong EW, Yusof MY, Mansor MB, Anbazhagan D, Ong SY, Sekaran SD. Disruption of adeB gene has a greater effect on resistance to meropenems than adeA gene in Acinetobacter spp. isolated from University Malaya Medical Centre. Singapore Med J. 2009 Aug; 50(8):822-6. PMID: 19710984.
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    61. Osman O, Fong MY, Sekaran SD. Genetic characterization of dengue virus type 1 isolated in Brunei in 2005-2006. J Gen Virol. 2009 Mar; 90(Pt 3):678-86. PMID: 19218214.
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    62. Hunsperger EA, Yoksan S, Buchy P, Nguyen VC, Sekaran SD, Enria DA, Pelegrino JL, Vázquez S, Artsob H, Drebot M, Gubler DJ, Halstead SB, Guzmán MG, Margolis HS, Nathanson CM, Rizzo Lic NR, Bessoff KE, Kliks S, Peeling RW. Evaluation of commercially available anti-dengue virus immunoglobulin M tests. Emerg Infect Dis. 2009 Mar; 15(3):436-40. PMID: 19239758.
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    63. Hwa WE, Subramaniam G, Navaratnam P, Sekaran SD. Detection and characterization of class 1 integrons among carbapenem-resistant isolates of Acinetobacter spp. in Malaysia. J Microbiol Immunol Infect. 2009 Feb; 42(1):54-62. PMID: 19424559.
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    64. Desa MN, Navaratnam P, Vadivelu J, Sekaran SD. Expression analysis of adherence-associated genes in pneumococcal clinical isolates during adherence to human respiratory epithelial cells (in vitro) by real-time PCR. FEMS Microbiol Lett. 2008 Nov; 288(1):125-30. PMID: 18795954.
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    65. Kumari N, Navaratnam P, Sekaran SD. Detection of pbp2b and ermB genes in clinical isolates of Streptococcus pneumoniae. J Infect Dev Ctries. 2008 Jun 01; 2(3):193-9. PMID: 19738350.
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    66. Kumari N, Subramaniam G, Navaratnam P, Sekaran SD. Molecular characterization of genes encoding the quinolone resistance determining regions of Malaysian Streptococcus pneumoniae strains. Indian J Med Microbiol. 2008 Apr-Jun; 26(2):148-50. PMID: 18445951.
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    67. Sekaran SD, Artsob H. Molecular diagnostics for the detection of human flavivirus infections. Expert Opin Med Diagn. 2007 Dec; 1(4):521-30. PMID: 23496358.
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    68. Wong EH, Subramaniam G, Navaratnam P, Sekaran SD. Rapid detection of non-enterobacteriaceae directly from positive blood culture using fluorescent in situ hybridization. Indian J Med Microbiol. 2007 Oct; 25(4):391-4. PMID: 18087092.
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    69. Desa MN, Sekaran SD, Vadivelu J, Parasakthi N. Distribution of CBP genes in Streptococcus pneumoniae isolates in relation to vaccine types, penicillin susceptibility and clinical site. Epidemiol Infect. 2008 Jul; 136(7):940-2. PMID: 17678563.
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    70. Yong YK, Thayan R, Chong HT, Tan CT, Sekaran SD. Rapid detection and serotyping of dengue virus by multiplex RT-PCR and real-time SYBR green RT-PCR. Singapore Med J. 2007 Jul; 48(7):662-8. PMID: 17609830.
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    71. Sabet NS, Subramaniam G, Navaratnam P, Sekaran SD. Detection of mecA and ermA genes and simultaneous identification of Staphylococcus aureus using triplex real-time PCR from Malaysian S. aureus strain collections. Int J Antimicrob Agents. 2007 May; 29(5):582-5. PMID: 17314034.
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    72. Gebriel AM, Subramaniam G, Sekaran SD. The detection and characterization of pathogenic Leptospira and the use of OMPs as potential antigens and immunogens. Trop Biomed. 2006 Dec; 23(2):194-207. PMID: 17322822.
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    73. Sabet NS, Subramaniam G, Navaratnam P, Sekaran SD. Detection of methicillin- and aminoglycoside-resistant genes and simultaneous identification of S. aureus using triplex real-time PCR Taqman assay. J Microbiol Methods. 2007 Jan; 68(1):157-62. PMID: 16935372.
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    74. Sabet NS, Subramaniam G, Navaratnam P, Sekaran SD. Simultaneous species identification and detection of methicillin resistance in staphylococci using triplex real-time PCR assay. Diagn Microbiol Infect Dis. 2006 Sep; 56(1):13-8. PMID: 16650954.
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