Loading...
Header Logo
Keywords
Last Name
Institution

Associate Professor Kevin John Saliba

Title[no position]
Institution[no institution name]
Address[no address]
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Spry C, Sewell AL, Hering Y, Villa MVJ, Weber J, Hobson SJ, Harnor SJ, Gul S, Marquez R, Saliba KJ. Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation. Eur J Med Chem. 2018 Jan 01; 143:1139-1147. PMID: 29233590.
      View in: PubMed
    2. Howieson VM, Tran E, Hoegl A, Fam HL, Fu J, Sivonen K, Li XX, Auclair K, Saliba KJ. Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency. Antimicrob Agents Chemother. 2016 12; 60(12):7146-7152. PMID: 27645235.
      View in: PubMed
    3. Macuamule CJ, Tjhin ET, Jana CE, Barnard L, Koekemoer L, de Villiers M, Saliba KJ, Strauss E. A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity. Antimicrob Agents Chemother. 2015; 59(6):3666-8. PMID: 25845876.
      View in: PubMed
    4. Berna AZ, McCarthy JS, Wang RX, Saliba KJ, Bravo FG, Cassells J, Padovan B, Trowell SC. Analysis of Breath Specimens for Biomarkers of Plasmodium falciparum Infection. J Infect Dis. 2015 Oct 01; 212(7):1120-8. PMID: 25810441.
      View in: PubMed
    5. Saliba KJ, Spry C. Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides. Biochem Soc Trans. 2014 Aug; 42(4):1087-93. PMID: 25110007.
      View in: PubMed
    6. Hoegl A, Darabi H, Tran E, Awuah E, Kerdo ES, Habib E, Saliba KJ, Auclair K. Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity. Bioorg Med Chem Lett. 2014 Aug 01; 24(15):3274-7. PMID: 24986662.
      View in: PubMed
    7. Spry C, Saliba KJ, Strauss E. A miniaturized assay for measuring small molecule phosphorylation in the presence of complex matrices. Anal Biochem. 2014 Apr 15; 451:76-8. PMID: 24333332.
      View in: PubMed
    8. Tjhin ET, Staines HM, van Schalkwyk DA, Krishna S, Saliba KJ. Studies with the Plasmodium falciparum hexokinase reveal that PfHT limits the rate of glucose entry into glycolysis. FEBS Lett. 2013 Oct 01; 587(19):3182-7. PMID: 23954294.
      View in: PubMed
    9. de Villiers M, Macuamule C, Spry C, Hyun YM, Strauss E, Saliba KJ. Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity. ACS Med Chem Lett. 2013 Aug 08; 4(8):784-9. PMID: 24900746.
      View in: PubMed
    10. van Schalkwyk DA, Saliba KJ, Biagini GA, Bray PG, Kirk K. Loss of pH control in Plasmodium falciparum parasites subjected to oxidative stress. PLoS One. 2013; 8(3):e58933. PMID: 23536836.
      View in: PubMed
    11. Spry C, Macuamule C, Lin Z, Virga KG, Lee RE, Strauss E, Saliba KJ. Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated. PLoS One. 2013; 8(2):e54974. PMID: 23405100.
      View in: PubMed
    12. Chan XW, Wrenger C, Stahl K, Bergmann B, Winterberg M, Müller IB, Saliba KJ. Chemical and genetic validation of thiamine utilization as an antimalarial drug target. Nat Commun. 2013; 4:2060. PMID: 23804074.
      View in: PubMed
    13. Baum J, Saliba KJ, Cooke BM. Editorial--Molecular Approaches to Malaria 2012 (MAM 2012). Int J Parasitol. 2012 May 15; 42(6):517. PMID: 22656266.
      View in: PubMed
    14. Spry C, van Schalkwyk DA, Strauss E, Saliba KJ. Pantothenate utilization by Plasmodium as a target for antimalarial chemotherapy. Infect Disord Drug Targets. 2010 Jun; 10(3):200-16. PMID: 20334619.
      View in: PubMed
    15. Henry RI, Cobbold SA, Allen RJ, Khan A, Hayward R, Lehane AM, Bray PG, Howitt SM, Biagini GA, Saliba KJ, Kirk K. An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum. J Biol Chem. 2010 Jun 11; 285(24):18615-26. PMID: 20332090.
      View in: PubMed
    16. van Schalkwyk DA, Chan XW, Misiano P, Gagliardi S, Farina C, Saliba KJ. Inhibition of Plasmodium falciparum pH regulation by small molecule indole derivatives results in rapid parasite death. Biochem Pharmacol. 2010 May 01; 79(9):1291-9. PMID: 20067768.
      View in: PubMed
    17. Spry C, Saliba KJ. The human malaria parasite Plasmodium falciparum is not dependent on host coenzyme A biosynthesis. J Biol Chem. 2009 Sep 11; 284(37):24904-13. PMID: 19584050.
      View in: PubMed
    18. Kirk K, Howitt SM, Bröer S, Saliba KJ, Downie MJ. Purine uptake in Plasmodium: transport versus metabolism. Trends Parasitol. 2009 Jun; 25(6):246-9. PMID: 19423394.
      View in: PubMed
    19. Saliba KJ, Lehane AM, Kirk K. A polymorphic drug pump in the malaria parasite. Mol Microbiol. 2008 Nov; 70(4):775-9. PMID: 18990178.
      View in: PubMed
    20. van Schalkwyk DA, Priebe W, Saliba KJ. The inhibitory effect of 2-halo derivatives of D-glucose on glycolysis and on the proliferation of the human malaria parasite Plasmodium falciparum. J Pharmacol Exp Ther. 2008 Nov; 327(2):511-7. PMID: 18713952.
      View in: PubMed
    21. Lehane AM, Saliba KJ. Common dietary flavonoids inhibit the growth of the intraerythrocytic malaria parasite. BMC Res Notes. 2008 Jun 18; 1:26. PMID: 18710482.
      View in: PubMed
    22. Lehane AM, Hayward R, Saliba KJ, Kirk K. A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites. J Cell Sci. 2008 May 15; 121(Pt 10):1624-32. PMID: 18445688.
      View in: PubMed
    23. Spry C, Kirk K, Saliba KJ. Coenzyme A biosynthesis: an antimicrobial drug target. FEMS Microbiol Rev. 2008 Jan; 32(1):56-106. PMID: 18173393.
      View in: PubMed
    24. Downie MJ, Saliba KJ, Bröer S, Howitt SM, Kirk K. Purine nucleobase transport in the intraerythrocytic malaria parasite. Int J Parasitol. 2008 Feb; 38(2):203-9. PMID: 17765902.
      View in: PubMed
    25. Lehane AM, Marchetti RV, Spry C, van Schalkwyk DA, Teng R, Kirk K, Saliba KJ. Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite. J Biol Chem. 2007 Aug 31; 282(35):25395-405. PMID: 17581817.
      View in: PubMed
    26. Staines HM, Alkhalil A, Allen RJ, De Jonge HR, Derbyshire E, Egée S, Ginsburg H, Hill DA, Huber SM, Kirk K, Lang F, Lisk G, Oteng E, Pillai AD, Rayavara K, Rouhani S, Saliba KJ, Shen C, Solomon T, Thomas SL, Verloo P, Desai SA. Electrophysiological studies of malaria parasite-infected erythrocytes: current status. Int J Parasitol. 2007 Apr; 37(5):475-82. PMID: 17292372.
      View in: PubMed
    27. Kirk K, Saliba KJ. Targeting nutrient uptake mechanisms in Plasmodium. Curr Drug Targets. 2007 Jan; 8(1):75-88. PMID: 17266532.
      View in: PubMed
    28. Saliba KJ, Martin RE, Bröer A, Henry RI, McCarthy CS, Downie MJ, Allen RJ, Mullin KA, McFadden GI, Bröer S, Kirk K. Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite. Nature. 2006 Oct 05; 443(7111):582-5. PMID: 17006451.
      View in: PubMed
    29. Downie MJ, Saliba KJ, Howitt SM, Bröer S, Kirk K. Transport of nucleosides across the Plasmodium falciparum parasite plasma membrane has characteristics of PfENT1. Mol Microbiol. 2006 May; 60(3):738-48. PMID: 16629674.
      View in: PubMed
    30. Hayward R, Saliba KJ, Kirk K. The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance. J Cell Sci. 2006 Mar 15; 119(Pt 6):1016-25. PMID: 16492710.
      View in: PubMed
    31. Spry C, Chai CL, Kirk K, Saliba KJ. A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites. Antimicrob Agents Chemother. 2005 Nov; 49(11):4649-57. PMID: 16251308.
      View in: PubMed
    32. Saliba KJ, Kirk K. CJ-15,801, a fungal natural product, inhibits the intraerythrocytic stage of Plasmodium falciparum in vitro via an effect on pantothenic acid utilisation. Mol Biochem Parasitol. 2005 May; 141(1):129-31. PMID: 15811536.
      View in: PubMed
    33. Hayward R, Saliba KJ, Kirk K. Mutations in pfmdr1 modulate the sensitivity of Plasmodium falciparum to the intrinsic antiplasmodial activity of verapamil. Antimicrob Agents Chemother. 2005 Feb; 49(2):840-2. PMID: 15673784.
      View in: PubMed
    34. Saliba KJ, Ferru I, Kirk K. Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite. Antimicrob Agents Chemother. 2005 Feb; 49(2):632-7. PMID: 15673744.
      View in: PubMed
    35. Hayward R, Saliba KJ, Kirk K. pfmdr1 mutations associated with chloroquine resistance incur a fitness cost in Plasmodium falciparum. Mol Microbiol. 2005 Feb; 55(4):1285-95. PMID: 15686571.
      View in: PubMed
    36. Kirk K, Martin RE, Bröer S, Howitt SM, Saliba KJ. Plasmodium permeomics: membrane transport proteins in the malaria parasite. Curr Top Microbiol Immunol. 2005; 295:325-56. PMID: 16265897.
      View in: PubMed
    37. Go ML, Liu M, Wilairat P, Rosenthal PJ, Saliba KJ, Kirk K. Antiplasmodial chalcones inhibit sorbitol-induced hemolysis of Plasmodium falciparum-infected erythrocytes. Antimicrob Agents Chemother. 2004 Sep; 48(9):3241-5. PMID: 15328079.
      View in: PubMed
    38. Lehane AM, Saliba KJ, Allen RJ, Kirk K. Choline uptake into the malaria parasite is energized by the membrane potential. Biochem Biophys Res Commun. 2004 Jul 23; 320(2):311-7. PMID: 15219828.
      View in: PubMed
    39. Saliba KJ, Krishna S, Kirk K. Inhibition of hexose transport and abrogation of pH homeostasis in the intraerythrocytic malaria parasite by an O-3-hexose derivative. FEBS Lett. 2004 Jul 16; 570(1-3):93-6. PMID: 15251446.
      View in: PubMed
    40. Saliba KJ, Allen RJ, Zissis S, Bray PG, Ward SA, Kirk K. Acidification of the malaria parasite's digestive vacuole by a H+-ATPase and a H+-pyrophosphatase. J Biol Chem. 2003 Feb 21; 278(8):5605-12. PMID: 12427765.
      View in: PubMed
    41. Bray PG, Saliba KJ, Davies JD, Spiller DG, White MR, Kirk K, Ward SA. Distribution of acridine orange fluorescence in Plasmodium falciparum-infected erythrocytes and its implications for the evaluation of digestive vacuole pH. Mol Biochem Parasitol. 2002 Feb; 119(2):301-4; discussion 307-9, 311-3. PMID: 11814584.
      View in: PubMed
    42. Kirk K, Saliba KJ. Chloroquine resistance and the pH of the malaria parasite's digestive vacuole. Drug Resist Updat. 2001 Dec; 4(6):335-7. PMID: 12030781.
      View in: PubMed
    43. Saliba KJ, Kirk K. Nutrient acquisition by intracellular apicomplexan parasites: staying in for dinner. Int J Parasitol. 2001 Oct; 31(12):1321-30. PMID: 11566300.
      View in: PubMed
    44. Elliott JL, Saliba KJ, Kirk K. Transport of lactate and pyruvate in the intraerythrocytic malaria parasite, Plasmodium falciparum. Biochem J. 2001 May 01; 355(Pt 3):733-9. PMID: 11311136.
      View in: PubMed
    45. Biagini GA, Knodler LA, Saliba KJ, Kirk K, Edwards MR. Na(+)-dependent pH regulation by the amitochondriate protozoan parasite Giardia intestinalis. J Biol Chem. 2001 Aug 03; 276(31):29157-62. PMID: 11297564.
      View in: PubMed
    46. Saliba KJ, Kirk K. H+-coupled pantothenate transport in the intracellular malaria parasite. J Biol Chem. 2001 May 25; 276(21):18115-21. PMID: 11278793.
      View in: PubMed
    47. Krishna S, Woodrow CJ, Burchmore RJ, Saliba KJ, Kirk K. Hexose transport in asexual stages of Plasmodium falciparum and kinetoplastidae. Parasitol Today. 2000 Dec; 16(12):516-21. PMID: 11121848.
      View in: PubMed
    48. Reed MB, Saliba KJ, Caruana SR, Kirk K, Cowman AF. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature. 2000 Feb 24; 403(6772):906-9. PMID: 10706290.
      View in: PubMed
    49. Saliba KJ, Kirk K. pH regulation in the intracellular malaria parasite, Plasmodium falciparum. H(+) extrusion via a V-type H(+)-ATPase. J Biol Chem. 1999 Nov 19; 274(47):33213-9. PMID: 10559194.
      View in: PubMed
    50. Kirk K, Staines HM, Martin RE, Saliba KJ. Transport properties of the host cell membrane. Novartis Found Symp. 1999; 226:55-66; discussion 66-73. PMID: 10645538.
      View in: PubMed
    51. Saliba KJ, Kirk K. Clotrimazole inhibits the growth of Plasmodium falciparum in vitro. Trans R Soc Trop Med Hyg. 1998 Nov-Dec; 92(6):666-7. PMID: 10326117.
      View in: PubMed
    52. Saliba KJ, Folb PI, Smith PJ. Role for the plasmodium falciparum digestive vacuole in chloroquine resistance. Biochem Pharmacol. 1998 Aug 01; 56(3):313-20. PMID: 9744568.
      View in: PubMed
    53. Saliba KJ, Kirk K. Uptake of an antiplasmodial protease inhibitor into Plasmodium falciparum-infected human erythrocytes via a parasite-induced pathway. Mol Biochem Parasitol. 1998 Aug 01; 94(2):297-301. PMID: 9747980.
      View in: PubMed
    54. Saliba KJ, Horner HA, Kirk K. Transport and metabolism of the essential vitamin pantothenic acid in human erythrocytes infected with the malaria parasite Plasmodium falciparum. J Biol Chem. 1998 Apr 24; 273(17):10190-5. PMID: 9553068.
      View in: PubMed
    Saliba's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description