Loading...
Header Logo
Keywords
Last Name
Institution

Professor Wesley Van Voorhis

Address[no address]
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Hulverson MA, Choi R, Arnold SLM, Schaefer DA, Hemphill A, McCloskey MC, Betzer DP, Müller J, Vidadala RSR, Whitman GR, Rivas KL, Barrett LK, Hackman RC, Love MS, McNamara CW, Shaughnessy TK, Kondratiuk A, Kurnick M, Banfor PN, Lynch JJ, Freiberg GM, Kempf DJ, Maly DJ, Riggs MW, Ojo KK, Van Voorhis WC. Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis. Int J Parasitol. 2017 10; 47(12):753-763. PMID: 28899690.
      View in: PubMed
    2. Van Voorhis WC, Doggett JS, Parsons M, Hulverson MA, Choi R, Arnold SLM, Riggs MW, Hemphill A, Howe DK, Mealey RH, Lau AOT, Merritt EA, Maly DJ, Fan E, Ojo KK. Extended-spectrum antiprotozoal bumped kinase inhibitors: A review. Exp Parasitol. 2017 Sep; 180:71-83. PMID: 28065755.
      View in: PubMed
    3. Huang W, Hulverson MA, Zhang Z, Choi R, Hart KJ, Kennedy M, Vidadala RSR, Maly DJ, Van Voorhis WC, Lindner SE, Fan E, Ojo KK. 5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents. Bioorg Med Chem Lett. 2016 11 15; 26(22):5487-5491. PMID: 27780638.
      View in: PubMed
    4. Ojo KK, Dangoudoubiyam S, Verma SK, Scheele S, DeRocher AE, Yeargan M, Choi R, Smith TR, Rivas KL, Hulverson MA, Barrett LK, Fan E, Maly DJ, Parsons M, Dubey JP, Howe DK, Van Voorhis WC. Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy. Int J Parasitol. 2016 Dec; 46(13-14):871-880. PMID: 27729271.
      View in: PubMed
    5. Craig JK, Risler JK, Loesch KA, Dong W, Baker D, Barrett LK, Subramanian S, Samudrala R, Van Voorhis WC. Mycobacterium Cytidylate Kinase Appears to Be an Undruggable Target. J Biomol Screen. 2016 Aug; 21(7):695-700. PMID: 27146385.
      View in: PubMed
    6. Yang B, Feng YJ, Vu H, McCormick B, Rowley J, Pedro L, Crowther GJ, Van Voorhis WC, Forster PI, Quinn RJ. Bioaffinity Mass Spectrometry Screening. J Biomol Screen. 2016 Feb; 21(2):194-200. PMID: 26773071.
      View in: PubMed
    7. Van Voorhis WC, Hooft van Huijsduijnen R, Wells TN. Profile of William C. Campbell, Satoshi Omura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine. Proc Natl Acad Sci U S A. 2015 Dec 29; 112(52):15773-6. PMID: 26699511.
      View in: PubMed
    8. Pedroni MJ, Vidadala RS, Choi R, Keyloun KR, Reid MC, Murphy RC, Barrett LK, Van Voorhis WC, Maly DJ, Ojo KK, Lau AO. Bumped kinase inhibitor prohibits egression in Babesia bovis. Vet Parasitol. 2016 Jan 15; 215:22-8. PMID: 26790733.
      View in: PubMed
    9. Huston CD, Spangenberg T, Burrows J, Willis P, Wells TN, van Voorhis W. A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments. PLoS Negl Trop Dis. 2015 Oct; 9(10):e0003987. PMID: 26447884.
      View in: PubMed
    10. Li T, Ziniel PD, He PQ, Kommer VP, Crowther GJ, He M, Liu Q, Van Voorhis WC, Williams DL, Wang MW. High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis. Infect Dis Poverty. 2015 Aug 31; 4:40. PMID: 26341081.
      View in: PubMed
    11. Winzer P, Müller J, Aguado-Martínez A, Rahman M, Balmer V, Manser V, Ortega-Mora LM, Ojo KK, Fan E, Maly DJ, Van Voorhis WC, Hemphill A. In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum. Antimicrob Agents Chemother. 2015 Oct; 59(10):6361-74. PMID: 26248379.
      View in: PubMed
    12. Wells TN, Hooft van Huijsduijnen R, Van Voorhis WC. Malaria medicines: a glass half full? Nat Rev Drug Discov. 2015 Jun; 14(6):424-42. PMID: 26000721.
      View in: PubMed
    13. Crowther GJ, Weller SM, Jones JC, Weaver T, Fan E, Van Voorhis WC, Rosen H. The Bacterial Sec Pathway of Protein Export: Screening and Follow-Up. J Biomol Screen. 2015 Aug; 20(7):921-6. PMID: 25987586.
      View in: PubMed
    14. Buchko GW, Edwards TE, Hewitt SN, Phan IQ, Van Voorhis WC, Miller SI, Myler PJ. Backbone chemical shift assignments for the sensor domain of the Burkholderia pseudomallei histidine kinase RisS: "missing" resonances at the dimer interface. Biomol NMR Assign. 2015 Oct; 9(2):381-5. PMID: 25957069.
      View in: PubMed
    15. Lorimer DD, Choi R, Abramov A, Nakazawa Hewitt S, Gardberg AS, Van Voorhis WC, Staker BL, Myler PJ, Edwards TE. Structures of a histidine triad family protein from Entamoeba histolytica bound to sulfate, AMP and GMP. Acta Crystallogr F Struct Biol Commun. 2015 May; 71(Pt 5):572-6. PMID: 25945711.
      View in: PubMed
    16. Abendroth J, Choi R, Wall A, Clifton MC, Lukacs CM, Staker BL, Van Voorhis W, Myler P, Lorimer DD, Edwards TE. Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia. Acta Crystallogr F Struct Biol Commun. 2015 May; 71(Pt 5):566-71. PMID: 25945710.
      View in: PubMed
    17. Moen SO, Fairman JW, Barnes SR, Sullivan A, Nakazawa-Hewitt S, Van Voorhis WC, Staker BL, Lorimer DD, Myler PJ, Edwards TE. Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP. Acta Crystallogr F Struct Biol Commun. 2015 May; 71(Pt 5):609-14. PMID: 25945716.
      View in: PubMed
    18. Buchko GW, Abendroth J, Clifton MC, Robinson H, Zhang Y, Hewitt SN, Staker BL, Edwards TE, Van Voorhis WC, Myler PJ. Structure of a CutA1 divalent-cation tolerance protein from Cryptosporidium parvum, the protozoal parasite responsible for cryptosporidiosis. Acta Crystallogr F Struct Biol Commun. 2015 May; 71(Pt 5):522-30. PMID: 25945704.
      View in: PubMed
    19. Edwards TE, Baugh L, Bullen J, Baydo RO, Witte P, Thompkins K, Phan IQ, Abendroth J, Clifton MC, Sankaran B, Van Voorhis WC, Myler PJ, Staker BL, Grundner C, Lorimer DD. Crystal structures of Mycobacterial MeaB and MMAA-like GTPases. J Struct Funct Genomics. 2015 Jun; 16(2):91-9. PMID: 25832174.
      View in: PubMed
    20. Hines SA, Ramsay JD, Kappmeyer LS, Lau AO, Ojo KK, Van Voorhis WC, Knowles DP, Mealey RH. Theileria equi isolates vary in susceptibility to imidocarb dipropionate but demonstrate uniform in vitro susceptibility to a bumped kinase inhibitor. Parasit Vectors. 2015 Jan 20; 8:33. PMID: 25600252.
      View in: PubMed
    21. Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ. Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb). 2015 Mar; 95(2):142-8. PMID: 25613812.
      View in: PubMed
    22. Talley AK, Healy SA, Finney OC, Murphy SC, Kublin J, Salas CJ, Lundebjerg S, Gilbert P, Van Voorhis WC, Whisler J, Wang R, Ockenhouse CF, Heppner DG, Kappe SH, Duffy PE. Safety and comparability of controlled human Plasmodium falciparum infection by mosquito bite in malaria-naïve subjects at a new facility for sporozoite challenge. PLoS One. 2014; 9(11):e109654. PMID: 25405724.
      View in: PubMed
    23. Lendner M, Böttcher D, Delling C, Ojo KK, Van Voorhis WC, Daugschies A. A novel CDPK1 inhibitor--a potential treatment for cryptosporidiosis in calves? Parasitol Res. 2015 Jan; 114(1):335-6. PMID: 25398685.
      View in: PubMed
    24. Keyloun KR, Reid MC, Choi R, Song Y, Fox AMW, Hillesland HK, Zhang Z, Vidadala R, Merritt EA, Lau AOT, Maly DJ, Fan E, Barrett LK, Van Voorhis WC, Ojo KK. The gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites. Parasitology. 2014 Sep; 141(11):1499-1509. PMID: 24927073.
      View in: PubMed
    25. Doggett JS, Ojo KK, Fan E, Maly DJ, Van Voorhis WC. Bumped kinase inhibitor 1294 treats established Toxoplasma gondii infection. Antimicrob Agents Chemother. 2014 Jun; 58(6):3547-9. PMID: 24687502.
      View in: PubMed
    26. Ojo KK, Reid MC, Kallur Siddaramaiah L, Müller J, Winzer P, Zhang Z, Keyloun KR, Vidadala RS, Merritt EA, Hol WG, Maly DJ, Fan E, Van Voorhis WC, Hemphill A. Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy. PLoS One. 2014; 9(3):e92929. PMID: 24681759.
      View in: PubMed
    27. Linford AS, Jiang NM, Edwards TE, Sherman NE, Van Voorhis WC, Stewart LJ, Myler PJ, Staker BL, Petri WA. Crystal structure and putative substrate identification for the Entamoeba histolytica low molecular weight tyrosine phosphatase. Mol Biochem Parasitol. 2014 Jan; 193(1):33-44. PMID: 24548880.
      View in: PubMed
    28. Vidadala RS, Ojo KK, Johnson SM, Zhang Z, Leonard SE, Mitra A, Choi R, Reid MC, Keyloun KR, Fox AM, Kennedy M, Silver-Brace T, Hume JC, Kappe S, Verlinde CL, Fan E, Merritt EA, Van Voorhis WC, Maly DJ. Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes. Eur J Med Chem. 2014 Mar 03; 74:562-73. PMID: 24531197.
      View in: PubMed
    29. Crowther GJ, Booker ML, He M, Li T, Raverdy S, Novelli JF, He P, Dale NR, Fife AM, Barker RH, Kramer ML, Van Voorhis WC, Carlow CK, Wang MW. Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screens. PLoS Negl Trop Dis. 2014; 8(1):e2628. PMID: 24416464.
      View in: PubMed
    30. Buchko GW, Hewitt SN, Van Voorhis WC, Myler PJ. Solution structure of a putative FKBP-type peptidyl-propyl cis-trans isomerase from Giardia lamblia. J Biomol NMR. 2013 Dec; 57(4):369-74. PMID: 24293257.
      View in: PubMed
    31. Ojo KK, Eastman RT, Vidadala R, Zhang Z, Rivas KL, Choi R, Lutz JD, Reid MC, Fox AM, Hulverson MA, Kennedy M, Isoherranen N, Kim LM, Comess KM, Kempf DJ, Verlinde CL, Su XZ, Kappe SH, Maly DJ, Fan E, Van Voorhis WC. A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation. J Infect Dis. 2014 Jan 15; 209(2):275-84. PMID: 24123773.
      View in: PubMed
    32. Vu H, Roullier C, Campitelli M, Trenholme KR, Gardiner DL, Andrews KT, Skinner-Adams T, Crowther GJ, Van Voorhis WC, Quinn RJ. Plasmodium gametocyte inhibition identified from a natural-product-based fragment library. ACS Chem Biol. 2013 Dec 20; 8(12):2654-9. PMID: 24079418.
      View in: PubMed
    33. Castellanos-Gonzalez A, White AC, Ojo KK, Vidadala RS, Zhang Z, Reid MC, Fox AM, Keyloun KR, Rivas K, Irani A, Dann SM, Fan E, Maly DJ, Van Voorhis WC. A novel calcium-dependent protein kinase inhibitor as a lead compound for treating cryptosporidiosis. J Infect Dis. 2013 Oct 15; 208(8):1342-8. PMID: 23878324.
      View in: PubMed
    34. Woodland A, Grimaldi R, Luksch T, Cleghorn LA, Ojo KK, Van Voorhis WC, Brenk R, Frearson JA, Gilbert IH, Wyatt PG. From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules. ChemMedChem. 2013 Jul; 8(7):1127-37. PMID: 23776181.
      View in: PubMed
    35. Buchko GW, Abendroth J, Robinson H, Zhang Y, Hewitt SN, Edwards TE, Van Voorhis WC, Myler PJ. Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia. J Struct Funct Genomics. 2013 Jun; 14(2):47-57. PMID: 23709284.
      View in: PubMed
    36. Koh CY, Kim JE, Napoli AJ, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Hol WG. Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Mol Biochem Parasitol. 2013 May; 189(1-2):26-32. PMID: 23665145.
      View in: PubMed
    37. Baugh L, Gallagher LA, Patrapuvich R, Clifton MC, Gardberg AS, Edwards TE, Armour B, Begley DW, Dieterich SH, Dranow DM, Abendroth J, Fairman JW, Fox D, Staker BL, Phan I, Gillespie A, Choi R, Nakazawa-Hewitt S, Nguyen MT, Napuli A, Barrett L, Buchko GW, Stacy R, Myler PJ, Stewart LJ, Manoil C, Van Voorhis WC. Combining functional and structural genomics to sample the essential Burkholderia structome. PLoS One. 2013; 8(1):e53851. PMID: 23382856.
      View in: PubMed
    38. Leibly DJ, Nguyen TN, Kao LT, Hewitt SN, Barrett LK, Van Voorhis WC. Stabilizing additives added during cell lysis aid in the solubilization of recombinant proteins. PLoS One. 2012; 7(12):e52482. PMID: 23285060.
      View in: PubMed
    39. Larson ET, Kim JE, Napuli AJ, Verlinde CL, Fan E, Zucker FH, Van Voorhis WC, Buckner FS, Hol WG, Merritt EA. Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia. Acta Crystallogr D Biol Crystallogr. 2012 Sep; 68(Pt 9):1194-200. PMID: 22948920.
      View in: PubMed
    40. Zhang Z, Ojo KK, Johnson SM, Larson ET, He P, Geiger JA, Castellanos-Gonzalez A, White AC, Parsons M, Merritt EA, Maly DJ, Verlinde CL, Van Voorhis WC, Fan E. Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1. Bioorg Med Chem Lett. 2012 Aug 15; 22(16):5264-7. PMID: 22795629.
      View in: PubMed
    41. Ojo KK, Pfander C, Mueller NR, Burstroem C, Larson ET, Bryan CM, Fox AM, Reid MC, Johnson SM, Murphy RC, Kennedy M, Mann H, Leibly DJ, Hewitt SN, Verlinde CL, Kappe S, Merritt EA, Maly DJ, Billker O, Van Voorhis WC. Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors. J Clin Invest. 2012 Jun; 122(6):2301-5. PMID: 22565309.
      View in: PubMed
    42. Larson ET, Ojo KK, Murphy RC, Johnson SM, Zhang Z, Kim JE, Leibly DJ, Fox AM, Reid MC, Dale EJ, Perera BG, Kim J, Hewitt SN, Hol WG, Verlinde CL, Fan E, Van Voorhis WC, Maly DJ, Merritt EA. Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J Med Chem. 2012 Mar 22; 55(6):2803-10. PMID: 22369268.
      View in: PubMed
    43. Johnson SM, Murphy RC, Geiger JA, DeRocher AE, Zhang Z, Ojo KK, Larson ET, Perera BG, Dale EJ, He P, Reid MC, Fox AM, Mueller NR, Merritt EA, Fan E, Parsons M, Van Voorhis WC, Maly DJ. Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity. J Med Chem. 2012 Mar 08; 55(5):2416-26. PMID: 22320388.
      View in: PubMed
    44. Crowther GJ, Quadri SA, Shannon-Alferes BJ, Van Voorhis WC, Rosen H. A mechanism-based whole-cell screening assay to identify inhibitors of protein export in Escherichia coli by the Sec pathway. J Biomol Screen. 2012 Apr; 17(4):535-41. PMID: 22233648.
      View in: PubMed
    45. Nwaka S, Besson D, Ramirez B, Maes L, Matheeussen A, Bickle Q, Mansour NR, Yousif F, Townson S, Gokool S, Cho-Ngwa F, Samje M, Misra-Bhattacharya S, Murthy PK, Fakorede F, Paris JM, Yeates C, Ridley R, Van Voorhis WC, Geary T. Integrated dataset of screening hits against multiple neglected disease pathogens. PLoS Negl Trop Dis. 2011 Dec; 5(12):e1412. PMID: 22247786.
      View in: PubMed
    46. Magariños MP, Carmona SJ, Crowther GJ, Ralph SA, Roos DS, Shanmugam D, Van Voorhis WC, Agüero F. TDR Targets: a chemogenomics resource for neglected diseases. Nucleic Acids Res. 2012 Jan; 40(Database issue):D1118-27. PMID: 22116064.
      View in: PubMed
    47. Engelson EJ, Buckner FS, Van Voorhis WC. An essential farnesylated kinesin in Trypanosoma brucei. PLoS One. 2011; 6(11):e26508. PMID: 22073170.
      View in: PubMed
    48. Edwards TE, Abramov AB, Smith ER, Baydo RO, Leonard JT, Leibly DJ, Thompkins KB, Clifton MC, Gardberg AS, Staker BL, Van Voorhis WC, Myler PJ, Stewart LJ. Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis. BMC Struct Biol. 2011 Oct 13; 11:39. PMID: 21995815.
      View in: PubMed
    49. Yates SP, Edwards TE, Bryan CM, Stein AJ, Van Voorhis WC, Myler PJ, Stewart LJ, Zheng J, Jia Z. Structural basis of the substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase. Biochemistry. 2011 Sep 27; 50(38):8103-6. PMID: 21870819.
      View in: PubMed
    50. Buchko GW, Hewitt SN, Napuli AJ, Van Voorhis WC, Myler PJ. Solution-state NMR structure and biophysical characterization of zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1148-53. PMID: 21904065.
      View in: PubMed
    51. Clifton MC, Abendroth J, Edwards TE, Leibly DJ, Gillespie AK, Ferrell M, Dieterich SH, Exley I, Staker BL, Myler PJ, Van Voorhis WC, Stewart LJ. Structure of the cystathionine ?-synthase MetB from Mycobacterium ulcerans. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1154-8. PMID: 21904066.
      View in: PubMed
    52. Phan I, Subramanian S, Olsen C, Edwards TE, Guo W, Zhang Y, Van Voorhis WC, Stewart LJ, Myler PJ. Structure of fumarate hydratase from Rickettsia prowazekii, the agent of typhus and suspected relative of the mitochondria. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1123-8. PMID: 21904061.
      View in: PubMed
    53. Nguyen TN, Abendroth J, Leibly DJ, Le KP, Guo W, Kelley A, Stewart L, Myler PJ, Van Voorhis WC. Structure of triosephosphate isomerase from Cryptosporidium parvum. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1095-9. PMID: 21904056.
      View in: PubMed
    54. Abendroth J, Sankaran B, Edwards TE, Gardberg AS, Dieterich S, Bhandari J, Napuli AJ, Van Voorhis WC, Staker BL, Myler PJ, Stewart LJ. BrabA.11339.a: anomalous diffraction and ligand binding guide towards the elucidation of the function of a 'putative ß-lactamase-like protein' from Brucella melitensis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1106-12. PMID: 21904058.
      View in: PubMed
    55. Subramanian S, Abendroth J, Phan IQ, Olsen C, Staker BL, Napuli A, Van Voorhis WC, Stacy R, Myler PJ. Structure of 3-ketoacyl-(acyl-carrier-protein) reductase from Rickettsia prowazekii at 2.25 Å resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1118-22. PMID: 21904060.
      View in: PubMed
    56. Zhang Y, Edwards TE, Begley DW, Abramov A, Thompkins KB, Ferrell M, Guo WJ, Phan I, Olsen C, Napuli A, Sankaran B, Stacy R, Van Voorhis WC, Stewart LJ, Myler PJ. Structure of nitrilotriacetate monooxygenase component B from Mycobacterium thermoresistibile. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1100-5. PMID: 21904057.
      View in: PubMed
    57. Leeper T, Zhang S, Van Voorhis WC, Myler PJ, Varani G. Comparative analysis of glutaredoxin domains from bacterial opportunistic pathogens. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1141-7. PMID: 21904064.
      View in: PubMed
    58. Buchko GW, Hewitt SN, Napuli AJ, Van Voorhis WC, Myler PJ. Solution structure of an arsenate reductase-related protein, YffB, from Brucella melitensis, the etiological agent responsible for brucellosis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1129-36. PMID: 21904062.
      View in: PubMed
    59. Buchko GW, Edwards TE, Abendroth J, Arakaki TL, Law L, Napuli AJ, Hewitt SN, Van Voorhis WC, Stewart LJ, Staker BL, Myler PJ. Structure of a Nudix hydrolase (MutT) in the Mg(2+)-bound state from Bartonella henselae, the bacterium responsible for cat scratch fever. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1078-83. PMID: 21904053.
      View in: PubMed
    60. Ferrell M, Abendroth J, Zhang Y, Sankaran B, Edwards TE, Staker BL, Van Voorhis WC, Stewart LJ, Myler PJ. Structure of aldose reductase from Giardia lamblia. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1113-7. PMID: 21904059.
      View in: PubMed
    61. Leibly DJ, Abendroth J, Bryan CM, Sankaran B, Kelley A, Barrett LK, Stewart L, Van Voorhis WC. Structure of thymidylate kinase from Ehrlichia chaffeensis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1090-4. PMID: 21904055.
      View in: PubMed
    62. Leibly DJ, Newling PA, Abendroth J, Guo W, Kelley A, Stewart LJ, Van Voorhis W. Structure of a cyclin-dependent kinase from Giardia lamblia. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1084-9. PMID: 21904054.
      View in: PubMed
    63. Edwards TE, Bryan CM, Leibly DJ, Dieterich SH, Abendroth J, Sankaran B, Sivam D, Staker BL, Van Voorhis WC, Myler PJ, Stewart LJ. Structures of a putative ?-class glutathione S-transferase from the pathogenic fungus Coccidioides immitis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1038-43. PMID: 21904047.
      View in: PubMed
    64. Bryan CM, Bhandari J, Napuli AJ, Leibly DJ, Choi R, Kelley A, Van Voorhis WC, Edwards TE, Stewart LJ. High-throughput protein production and purification at the Seattle Structural Genomics Center for Infectious Disease. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1010-4. PMID: 21904042.
      View in: PubMed
    65. Hewitt SN, Choi R, Kelley A, Crowther GJ, Napuli AJ, Van Voorhis WC. Expression of proteins in Escherichia coli as fusions with maltose-binding protein to rescue non-expressed targets in a high-throughput protein-expression and purification pipeline. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1006-9. PMID: 21904041.
      View in: PubMed
    66. Begley DW, Davies DR, Hartley RC, Hewitt SN, Rychel AL, Myler PJ, Van Voorhis WC, Staker BL, Stewart LJ. Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1060-9. PMID: 21904051.
      View in: PubMed
    67. Stacy R, Begley DW, Phan I, Staker BL, Van Voorhis WC, Varani G, Buchko GW, Stewart LJ, Myler PJ. Structural genomics of infectious disease drug targets: the SSGCID. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):979-84. PMID: 21904037.
      View in: PubMed
    68. Barnwal RP, Van Voorhis WC, Varani G. NMR structure of an acyl-carrier protein from Borrelia burgdorferi. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1137-40. PMID: 21904063.
      View in: PubMed
    69. Edwards TE, Leibly DJ, Bhandari J, Statnekov JB, Phan I, Dieterich SH, Abendroth J, Staker BL, Van Voorhis WC, Myler PJ, Stewart LJ. Structures of phosphopantetheine adenylyltransferase from Burkholderia pseudomallei. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):1032-7. PMID: 21904046.
      View in: PubMed
    70. Choi R, Kelley A, Leibly D, Hewitt SN, Napuli A, Van Voorhis W. Immobilized metal-affinity chromatography protein-recovery screening is predictive of crystallographic structure success. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 01; 67(Pt 9):998-1005. PMID: 21904040.
      View in: PubMed
    71. Shibata S, Zhang Z, Korotkov KV, Delarosa J, Napuli A, Kelley AM, Mueller N, Ross J, Zucker FH, Buckner FS, Merritt EA, Verlinde CL, Van Voorhis WC, Hol WG, Fan E. Screening a fragment cocktail library using ultrafiltration. Anal Bioanal Chem. 2011 Sep; 401(5):1585-91. PMID: 21750879.
      View in: PubMed
    72. Oduor RO, Ojo KK, Williams GP, Bertelli F, Mills J, Maes L, Pryde DC, Parkinson T, Van Voorhis WC, Holler TP. Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads. PLoS Negl Trop Dis. 2011 Apr 05; 5(4):e1017. PMID: 21483717.
      View in: PubMed
    73. Larson ET, Kim JE, Castaneda LJ, Napuli AJ, Zhang Z, Fan E, Zucker FH, Verlinde CL, Buckner FS, Van Voorhis WC, Hol WG, Merritt EA. The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer. J Mol Biol. 2011 Jun 03; 409(2):159-76. PMID: 21420975.
      View in: PubMed
    74. Shibata S, Gillespie JR, Kelley AM, Napuli AJ, Zhang Z, Kovzun KV, Pefley RM, Lam J, Zucker FH, Van Voorhis WC, Merritt EA, Hol WG, Verlinde CL, Fan E, Buckner FS. Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice. Antimicrob Agents Chemother. 2011 May; 55(5):1982-9. PMID: 21282428.
      View in: PubMed
    75. Bauman A, Higdon R, Rapson S, Loiue B, Hogan J, Stacy R, Napuli A, Guo W, van Voorhis W, Roach J, Lu V, Landorf E, Stewart E, Kolker N, Collart F, Myler P, van Belle G, Kolker E. Design and initial characterization of the SC-200 proteomics standard mixture. OMICS. 2011 Jan-Feb; 15(1-2):73-82. PMID: 21250827.
      View in: PubMed
    76. Merritt EA, Arakaki TL, Gillespie R, Napuli AJ, Kim JE, Buckner FS, Van Voorhis WC, Verlinde CL, Fan E, Zucker F, Hol WG. Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol Biochem Parasitol. 2011 May; 177(1):20-8. PMID: 21255615.
      View in: PubMed
    77. Begley DW, Davies DR, Hartley RC, Edwards TE, Staker BL, Van Voorhis WC, Myler PJ, Stewart LJ. Fragment screening of infectious disease targets in a structural genomics environment. Methods Enzymol. 2011; 493:533-56. PMID: 21371605.
      View in: PubMed
    78. Ojo KK, Arakaki TL, Napuli AJ, Inampudi KK, Keyloun KR, Zhang L, Hol WG, Verlinde CL, Merritt EA, Van Voorhis WC. Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3. Mol Biochem Parasitol. 2011 Apr; 176(2):98-108. PMID: 21195115.
      View in: PubMed
    79. Larson ET, Kim JE, Zucker FH, Kelley A, Mueller N, Napuli AJ, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Merritt EA, Hol WG. Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate. Biochimie. 2011 Mar; 93(3):570-82. PMID: 21144880.
      View in: PubMed
    80. Fletcher S, Keaney EP, Cummings CG, Blaskovich MA, Hast MA, Glenn MP, Chang SY, Bucher CJ, Floyd RJ, Katt WP, Gelb MH, Van Voorhis WC, Beese LS, Sebti SM, Hamilton AD. Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents. J Med Chem. 2010 Oct 14; 53(19):6867-88. PMID: 20822181.
      View in: PubMed
    81. Edwards TE, Phan I, Abendroth J, Dieterich SH, Masoudi A, Guo W, Hewitt SN, Kelley A, Leibly D, Brittnacher MJ, Staker BL, Miller SI, Van Voorhis WC, Myler PJ, Stewart LJ. Structure of a Burkholderia pseudomallei trimeric autotransporter adhesin head. PLoS One. 2010 Sep 20; 5(9). PMID: 20862217.
      View in: PubMed
    82. Crowther GJ, Napuli AJ, Gilligan JH, Gagaring K, Borboa R, Francek C, Chen Z, Dagostino EF, Stockmyer JB, Wang Y, Rodenbough PP, Castaneda LJ, Leibly DJ, Bhandari J, Gelb MH, Brinker A, Engels IH, Taylor J, Chatterjee AK, Fantauzzi P, Glynne RJ, Van Voorhis WC, Kuhen KL. Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds. Mol Biochem Parasitol. 2011 Jan; 175(1):21-9. PMID: 20813141.
      View in: PubMed
    83. Crowther GJ, Shanmugam D, Carmona SJ, Doyle MA, Hertz-Fowler C, Berriman M, Nwaka S, Ralph SA, Roos DS, Van Voorhis WC, Agüero F. Identification of attractive drug targets in neglected-disease pathogens using an in silico approach. PLoS Negl Trop Dis. 2010 Aug 24; 4(8):e804. PMID: 20808766.
      View in: PubMed
    84. Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley PL, Castro S, Angulo-Barturen I, Ferrer S, Rosenthal PJ, Derisi JL, Sullivan DJ, Lazo JS, Roos DS, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM, Guy RK. Chemical genetics of Plasmodium falciparum. Nature. 2010 May 20; 465(7296):311-5. PMID: 20485428.
      View in: PubMed
    85. Arakaki TL, Carter M, Napuli AJ, Verlinde CL, Fan E, Zucker F, Buckner FS, Van Voorhis WC, Hol WG, Merritt EA. The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs. J Struct Biol. 2010 Aug; 171(2):238-43. PMID: 20438846.
      View in: PubMed
    86. Ojo KK, Larson ET, Keyloun KR, Castaneda LJ, Derocher AE, Inampudi KK, Kim JE, Arakaki TL, Murphy RC, Zhang L, Napuli AJ, Maly DJ, Verlinde CL, Buckner FS, Parsons M, Hol WG, Merritt EA, Van Voorhis WC. Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nat Struct Mol Biol. 2010 May; 17(5):602-7. PMID: 20436472.
      View in: PubMed
    87. Zucker FH, Stewart C, dela Rosa J, Kim J, Zhang L, Xiao L, Ross J, Napuli AJ, Mueller N, Castaneda LJ, Nakazawa Hewitt SR, Arakaki TL, Larson ET, Subramanian E, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Merritt EA, Hol WG. Prediction of protein crystallization outcome using a hybrid method. J Struct Biol. 2010 Jul; 171(1):64-73. PMID: 20347992.
      View in: PubMed
    88. Merritt EA, Arakaki TL, Gillespie JR, Larson ET, Kelley A, Mueller N, Napuli AJ, Kim J, Zhang L, Verlinde CL, Fan E, Zucker F, Buckner FS, van Voorhis WC, Hol WG. Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. J Mol Biol. 2010 Mar 26; 397(2):481-94. PMID: 20132829.
      View in: PubMed
    89. Larson ET, Mudeppa DG, Gillespie JR, Mueller N, Napuli AJ, Arif JA, Ross J, Arakaki TL, Lauricella A, Detitta G, Luft J, Zucker F, Verlinde CL, Fan E, Van Voorhis WC, Buckner FS, Rathod PK, Hol WG, Merritt EA. The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase. J Mol Biol. 2010 Mar 12; 396(5):1244-59. PMID: 20070944.
      View in: PubMed
    90. Odom AR, Van Voorhis WC. Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene. Mol Biochem Parasitol. 2010 Apr; 170(2):108-11. PMID: 20018214.
      View in: PubMed
    91. Crowther GJ, He P, Rodenbough PP, Thomas AP, Kovzun KV, Leibly DJ, Bhandari J, Castaneda LJ, Hol WG, Gelb MH, Napuli AJ, Van Voorhis WC. Use of thermal melt curves to assess the quality of enzyme preparations. Anal Biochem. 2010 Apr 15; 399(2):268-75. PMID: 20018159.
      View in: PubMed
    92. Myler PJ, Stacy R, Stewart L, Staker BL, Van Voorhis WC, Varani G, Buchko GW. The Seattle Structural Genomics Center for Infectious Disease (SSGCID). Infect Disord Drug Targets. 2009 Nov; 9(5):493-506. PMID: 19594426.
      View in: PubMed
    93. Merritt EA, Arakaki TL, Larson ET, Kelley A, Mueller N, Napuli AJ, Zhang L, Deditta G, Luft J, Verlinde CL, Fan E, Zucker F, Buckner FS, Van Voorhis WC, Hol WG. Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica. Mol Biochem Parasitol. 2010 Feb; 169(2):95-100. PMID: 19874856.
      View in: PubMed
    94. Van Voorhis WC, Hol WG, Myler PJ, Stewart LJ. The role of medical structural genomics in discovering new drugs for infectious diseases. PLoS Comput Biol. 2009 Oct; 5(10):e1000530. PMID: 19855826.
      View in: PubMed
    95. Boggild AK, Nicks BA, Yen L, Van Voorhis W, McMullen R, Buckner FS, Liles WC. Delusional parasitosis: six-year experience with 23 consecutive cases at an academic medical center. Int J Infect Dis. 2010 Apr; 14(4):e317-21. PMID: 19683952.
      View in: PubMed
    96. Suryadevara PK, Olepu S, Lockman JW, Ohkanda J, Karimi M, Verlinde CL, Kraus JM, Schoepe J, Van Voorhis WC, Hamilton AD, Buckner FS, Gelb MH. Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease. J Med Chem. 2009 Jun 25; 52(12):3703-15. PMID: 19463001.
      View in: PubMed
    97. Buchko GW, Hewitt SN, Napuli AJ, Van Voorhis WC, Myler PJ. Backbone and side chain (1)H, (13)C, and (15)N NMR assignments for the organic hydroperoxide resistance protein (Ohr) from Burkholderia pseudomallei. Biomol NMR Assign. 2009 Dec; 3(2):163-6. PMID: 19888681.
      View in: PubMed
    98. Crowther GJ, Napuli AJ, Thomas AP, Chung DJ, Kovzun KV, Leibly DJ, Castaneda LJ, Bhandari J, Damman CJ, Hui R, Hol WG, Buckner FS, Verlinde CL, Zhang Z, Fan E, van Voorhis WC. Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands. J Biomol Screen. 2009 Jul; 14(6):700-7. PMID: 19470714.
      View in: PubMed
    99. Hast MA, Fletcher S, Cummings CG, Pusateri EE, Blaskovich MA, Rivas K, Gelb MH, Van Voorhis WC, Sebti SM, Hamilton AD, Beese LS. Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem Biol. 2009 Feb 27; 16(2):181-92. PMID: 19246009.
      View in: PubMed
    100. Verlinde CL, Fan E, Shibata S, Zhang Z, Sun Z, Deng W, Ross J, Kim J, Xiao L, Arakaki TL, Bosch J, Caruthers JM, Larson ET, Letrong I, Napuli A, Kelly A, Mueller N, Zucker F, Van Voorhis WC, Buckner FS, Merritt EA, Hol WG. Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium. Curr Top Med Chem. 2009; 9(18):1678-87. PMID: 19929835.
      View in: PubMed
    101. Agüero F, Al-Lazikani B, Aslett M, Berriman M, Buckner FS, Campbell RK, Carmona S, Carruthers IM, Chan AW, Chen F, Crowther GJ, Doyle MA, Hertz-Fowler C, Hopkins AL, McAllister G, Nwaka S, Overington JP, Pain A, Paolini GV, Pieper U, Ralph SA, Riechers A, Roos DS, Sali A, Shanmugam D, Suzuki T, Van Voorhis WC, Verlinde CL. Genomic-scale prioritization of drug targets: the TDR Targets database. Nat Rev Drug Discov. 2008 11; 7(11):900-7. PMID: 18927591.
      View in: PubMed
    102. Fletcher S, Cummings CG, Rivas K, Katt WP, Hornéy C, Buckner FS, Chakrabarti D, Sebti SM, Gelb MH, Van Voorhis WC, Hamilton AD. Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation. J Med Chem. 2008 Sep 11; 51(17):5176-97. PMID: 18686940.
      View in: PubMed
    103. Ojo KK, Gillespie JR, Riechers AJ, Napuli AJ, Verlinde CL, Buckner FS, Gelb MH, Domostoj MM, Wells SJ, Scheer A, Wells TN, Van Voorhis WC. Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy. Antimicrob Agents Chemother. 2008 Oct; 52(10):3710-7. PMID: 18644955.
      View in: PubMed
    104. Larson ET, Deng W, Krumm BE, Napuli A, Mueller N, Van Voorhis WC, Buckner FS, Fan E, Lauricella A, DeTitta G, Luft J, Zucker F, Hol WG, Verlinde CL, Merritt EA. Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. J Mol Biol. 2008 Sep 12; 381(4):975-88. PMID: 18602399.
      View in: PubMed
    105. Merritt EA, Holmes M, Buckner FS, Van Voorhis WC, Quartly E, Phizicky EM, Lauricella A, Luft J, DeTitta G, Neely H, Zucker F, Hol WG. Structure of a Trypanosoma brucei alpha/beta-hydrolase fold protein with unknown function. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 01; 64(Pt 6):474-8. PMID: 18540054.
      View in: PubMed
    106. Arakaki TL, Buckner FS, Gillespie JR, Malmquist NA, Phillips MA, Kalyuzhniy O, Luft JR, Detitta GT, Verlinde CL, Van Voorhis WC, Hol WG, Merritt EA. Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies. Mol Microbiol. 2008 Apr; 68(1):37-50. PMID: 18312275.
      View in: PubMed
    107. Bulbule VJ, Rivas K, Verlinde CL, Van Voorhis WC, Gelb MH. 2-Oxotetrahydroquinoline-based antimalarials with high potency and metabolic stability. J Med Chem. 2008 Feb 14; 51(3):384-7. PMID: 18198825.
      View in: PubMed
    108. Jenwitheesuk E, Horst JA, Rivas KL, Van Voorhis WC, Samudrala R. Novel paradigms for drug discovery: computational multitarget screening. Trends Pharmacol Sci. 2008 Feb; 29(2):62-71. PMID: 18190973.
      View in: PubMed
    109. Fan E, Baker D, Fields S, Gelb MH, Buckner FS, Van Voorhis WC, Phizicky E, Dumont M, Mehlin C, Grayhack E, Sullivan M, Verlinde C, Detitta G, Meldrum DR, Merritt EA, Earnest T, Soltis M, Zucker F, Myler PJ, Schoenfeld L, Kim D, Worthey L, Lacount D, Vignali M, Li J, Mondal S, Massey A, Carroll B, Gulde S, Luft J, Desoto L, Holl M, Caruthers J, Bosch J, Robien M, Arakaki T, Holmes M, Le Trong I, Hol WG. Structural genomics of pathogenic protozoa: an overview. Methods Mol Biol. 2008; 426:497-513. PMID: 18542886.
      View in: PubMed
    110. Olepu S, Suryadevara PK, Rivas K, Yokoyama K, Verlinde CL, Chakrabarti D, Van Voorhis WC, Gelb MH. 2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials. Bioorg Med Chem Lett. 2008 Jan 15; 18(2):494-7. PMID: 18077162.
      View in: PubMed
    111. Yokoyama K, Gillespie JR, Van Voorhis WC, Buckner FS, Gelb MH. Protein geranylgeranyltransferase-I of Trypanosoma cruzi. Mol Biochem Parasitol. 2008 Jan; 157(1):32-43. PMID: 17996962.
      View in: PubMed
    112. Bendale P, Olepu S, Suryadevara PK, Bulbule V, Rivas K, Nallan L, Smart B, Yokoyama K, Ankala S, Pendyala PR, Floyd D, Lombardo LJ, Williams DK, Buckner FS, Chakrabarti D, Verlinde CL, Van Voorhis WC, Gelb MH. Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials. J Med Chem. 2007 Sep 20; 50(19):4585-605. PMID: 17722901.
      View in: PubMed
    113. Van Voorhis WC, Rivas KL, Bendale P, Nallan L, Hornéy C, Barrett LK, Bauer KD, Smart BP, Ankala S, Hucke O, Verlinde CL, Chakrabarti D, Strickland C, Yokoyama K, Buckner FS, Hamilton AD, Williams DK, Lombardo LJ, Floyd D, Gelb MH. Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase. Antimicrob Agents Chemother. 2007 Oct; 51(10):3659-71. PMID: 17606674.
      View in: PubMed
    114. Barrio AB, Van Voorhis WC, Basombrío MA. Trypanosoma cruzi: attenuation of virulence and protective immunogenicity after monoallelic disruption of the cub gene. Exp Parasitol. 2007 Dec; 117(4):382-9. PMID: 17624327.
      View in: PubMed
    115. Gillespie JR, Yokoyama K, Lu K, Eastman RT, Bollinger JG, Van Voorhis WC, Gelb MH, Buckner FS. C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins. Mol Biochem Parasitol. 2007 Jun; 153(2):115-24. PMID: 17397944.
      View in: PubMed
    116. Arakaki T, Neely H, Boni E, Mueller N, Buckner FS, Van Voorhis WC, Lauricella A, DeTitta G, Luft J, Hol WG, Merritt EA. The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 01; 63(Pt 3):178-82. PMID: 17329808.
      View in: PubMed
    117. Eastman RT, White J, Hucke O, Yokoyama K, Verlinde CL, Hast MA, Beese LS, Gelb MH, Rathod PK, Van Voorhis WC. Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. Mol Biochem Parasitol. 2007 Mar; 152(1):66-71. PMID: 17208314.
      View in: PubMed
    118. Giacani L, Molini B, Godornes C, Barrett L, Van Voorhis W, Centurion-Lara A, Lukehart SA. Quantitative analysis of tpr gene expression in Treponema pallidum isolates: Differences among isolates and correlation with T-cell responsiveness in experimental syphilis. Infect Immun. 2007 Jan; 75(1):104-12. PMID: 17030565.
      View in: PubMed
    119. Bosch J, Robien MA, Mehlin C, Boni E, Riechers A, Buckner FS, Van Voorhis WC, Myler PJ, Worthey EA, DeTitta G, Luft JR, Lauricella A, Gulde S, Anderson LA, Kalyuzhniy O, Neely HM, Ross J, Earnest TN, Soltis M, Schoenfeld L, Zucker F, Merritt EA, Fan E, Verlinde CL, Hol WG. Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J Med Chem. 2006 Oct 05; 49(20):5939-46. PMID: 17004709.
      View in: PubMed
    120. Gelb MH, Brunsveld L, Hrycyna CA, Michaelis S, Tamanoi F, Van Voorhis WC, Waldmann H. Therapeutic intervention based on protein prenylation and associated modifications. Nat Chem Biol. 2006 Oct; 2(10):518-28. PMID: 16983387.
      View in: PubMed
    121. Glenn MP, Chang SY, Hornéy C, Rivas K, Yokoyama K, Pusateri EE, Fletcher S, Cummings CG, Buckner FS, Pendyala PR, Chakrabarti D, Sebti SM, Gelb M, Van Voorhis WC, Hamilton AD. Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites. J Med Chem. 2006 Sep 21; 49(19):5710-27. PMID: 16970397.
      View in: PubMed
    122. Centurion-Lara A, Molini BJ, Godornes C, Sun E, Hevner K, Van Voorhis WC, Lukehart SA. Molecular differentiation of Treponema pallidum subspecies. J Clin Microbiol. 2006 Sep; 44(9):3377-80. PMID: 16954278.
      View in: PubMed
    123. LaFond RE, Molini BJ, Van Voorhis WC, Lukehart SA. Antigenic variation of TprK V regions abrogates specific antibody binding in syphilis. Infect Immun. 2006 Nov; 74(11):6244-51. PMID: 16923793.
      View in: PubMed
    124. Mehlin C, Boni E, Buckner FS, Engel L, Feist T, Gelb MH, Haji L, Kim D, Liu C, Mueller N, Myler PJ, Reddy JT, Sampson JN, Subramanian E, Van Voorhis WC, Worthey E, Zucker F, Hol WG. Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes. Mol Biochem Parasitol. 2006 Aug; 148(2):144-60. PMID: 16644028.
      View in: PubMed
    125. Holmes MA, Buckner FS, Van Voorhis WC, Verlinde CL, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Zucker F, Schoenfeld LW, Earnest TN, Hol WG, Merritt EA. Structure of ribose 5-phosphate isomerase from Plasmodium falciparum. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 01; 62(Pt 5):427-31. PMID: 16682767.
      View in: PubMed
    126. Robien MA, Bosch J, Buckner FS, Van Voorhis WC, Worthey EA, Myler P, Mehlin C, Boni EE, Kalyuzhniy O, Anderson L, Lauricella A, Gulde S, Luft JR, DeTitta G, Caruthers JM, Hodgson KO, Soltis M, Zucker F, Verlinde CL, Merritt EA, Schoenfeld LW, Hol WG. Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site. Proteins. 2006 Mar 15; 62(3):570-7. PMID: 16345073.
      View in: PubMed
    127. LaFond RE, Centurion-Lara A, Godornes C, Van Voorhis WC, Lukehart SA. TprK sequence diversity accumulates during infection of rabbits with Treponema pallidum subsp. pallidum Nichols strain. Infect Immun. 2006 Mar; 74(3):1896-906. PMID: 16495565.
      View in: PubMed
    128. Holmes MA, Buckner FS, Van Voorhis WC, Mehlin C, Boni E, Earnest TN, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Zucker F, Schoenfeld LW, Hol WG, Merritt EA. Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Mar 01; 62(Pt 3):180-5. PMID: 16511296.
      View in: PubMed
    129. Caruthers J, Bosch J, Buckner F, Van Voorhis W, Myler P, Worthey E, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Kalyuzhniy O, Anderson L, Zucker F, Soltis M, Hol WG. Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum. Proteins. 2006 Feb 01; 62(2):338-42. PMID: 16304640.
      View in: PubMed
    130. Eastman RT, Buckner FS, Yokoyama K, Gelb MH, Van Voorhis WC. Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation. J Lipid Res. 2006 Feb; 47(2):233-40. PMID: 16339110.
      View in: PubMed
    131. Eastman RT, Barrett LK, Dupuis K, Buckner FS, Van Voorhis WC. Leishmania inactivation in human pheresis platelets by a psoralen (amotosalen HCl) and long-wavelength ultraviolet irradiation. Transfusion. 2005 Sep; 45(9):1459-63. PMID: 16131378.
      View in: PubMed
    132. Glenn MP, Chang SY, Hucke O, Verlinde CL, Rivas K, Hornéy C, Yokoyama K, Buckner FS, Pendyala PR, Chakrabarti D, Gelb M, Van Voorhis WC, Sebti SM, Hamilton AD. Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites. Angew Chem Int Ed Engl. 2005 Aug 05; 44(31):4903-6. PMID: 16007716.
      View in: PubMed
    133. Buckner FS, Eastman RT, Yokoyama K, Gelb MH, Van Voorhis WC. Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis. Curr Opin Investig Drugs. 2005 Aug; 6(8):791-7. PMID: 16121685.
      View in: PubMed
    134. Nallan L, Bauer KD, Bendale P, Rivas K, Yokoyama K, Hornéy CP, Pendyala PR, Floyd D, Lombardo LJ, Williams DK, Hamilton A, Sebti S, Windsor WT, Weber PC, Buckner FS, Chakrabarti D, Gelb MH, Van Voorhis WC. Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J Med Chem. 2005 Jun 02; 48(11):3704-13. PMID: 15916422.
      View in: PubMed
    135. Duthie MS, Cetron MS, Van Voorhis WC, Kahn SJ. Trypanosoma cruzi-infected individuals demonstrate varied antibody responses to a panel of trans-sialidase proteins encoded by SA85-1 genes. Acta Trop. 2005 Mar; 93(3):317-29. PMID: 15725381.
      View in: PubMed
    136. Eastman RT, White J, Hucke O, Bauer K, Yokoyama K, Nallan L, Chakrabarti D, Verlinde CL, Gelb MH, Rathod PK, Van Voorhis WC. Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum. J Biol Chem. 2005 Apr 08; 280(14):13554-9. PMID: 15661734.
      View in: PubMed
    137. Carrico D, Ohkanda J, Kendrick H, Yokoyama K, Blaskovich MA, Bucher CJ, Buckner FS, Van Voorhis WC, Chakrabarti D, Croft SL, Gelb MH, Sebti SM, Hamilton AD. In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability. Bioorg Med Chem. 2004 Dec 15; 12(24):6517-26. PMID: 15556768.
      View in: PubMed
    138. Giacani L, Sun ES, Hevner K, Molini BJ, Van Voorhis WC, Lukehart SA, Centurion-Lara A. Tpr homologs in Treponema paraluiscuniculi Cuniculi A strain. Infect Immun. 2004 Nov; 72(11):6561-76. PMID: 15501788.
      View in: PubMed
    139. Sun ES, Molini BJ, Barrett LK, Centurion-Lara A, Lukehart SA, Van Voorhis WC. Subfamily I Treponema pallidum repeat protein family: sequence variation and immunity. Microbes Infect. 2004 Jul; 6(8):725-37. PMID: 15207819.
      View in: PubMed
    140. Centurion-Lara A, LaFond RE, Hevner K, Godornes C, Molini BJ, Van Voorhis WC, Lukehart SA. Gene conversion: a mechanism for generation of heterogeneity in the tprK gene of Treponema pallidum during infection. Mol Microbiol. 2004 Jun; 52(6):1579-96. PMID: 15186410.
      View in: PubMed
    141. Lichtenwalner AB, Patton DL, Van Voorhis WC, Sweeney YT, Kuo CC. Heat shock protein 60 is the major antigen which stimulates delayed-type hypersensitivity reaction in the macaque model of Chlamydia trachomatis salpingitis. Infect Immun. 2004 Feb; 72(2):1159-61. PMID: 14742566.
      View in: PubMed
    142. Ohkanda J, Buckner FS, Lockman JW, Yokoyama K, Carrico D, Eastman R, de Luca-Fradley K, Davies W, Croft SL, Van Voorhis WC, Gelb MH, Sebti SM, Hamilton AD. Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents. J Med Chem. 2004 Jan 15; 47(2):432-45. PMID: 14711313.
      View in: PubMed
    143. Buckner F, Yokoyama K, Lockman J, Aikenhead K, Ohkanda J, Sadilek M, Sebti S, Van Voorhis W, Hamilton A, Gelb MH. A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):15149-53. PMID: 14657358.
      View in: PubMed
    144. LaFond RE, Centurion-Lara A, Godornes C, Rompalo AM, Van Voorhis WC, Lukehart SA. Sequence diversity of Treponema pallidum subsp. pallidum tprK in human syphilis lesions and rabbit-propagated isolates. J Bacteriol. 2003 Nov; 185(21):6262-8. PMID: 14563860.
      View in: PubMed
    145. Morgan CA, Lukehart SA, Van Voorhis WC. Protection against syphilis correlates with specificity of antibodies to the variable regions of Treponema pallidum repeat protein K. Infect Immun. 2003 Oct; 71(10):5605-12. PMID: 14500480.
      View in: PubMed
    146. Leader BT, Hevner K, Molini BJ, Barrett LK, Van Voorhis WC, Lukehart SA. Antibody responses elicited against the Treponema pallidum repeat proteins differ during infection with different isolates of Treponema pallidum subsp. pallidum. Infect Immun. 2003 Oct; 71(10):6054-7. PMID: 14500529.
      View in: PubMed
    147. Van Voorhis WC, Barrett LK, Lukehart SA, Schmidt B, Schriefer M, Cameron CE. Serodiagnosis of syphilis: antibodies to recombinant Tp0453, Tp92, and Gpd proteins are sensitive and specific indicators of infection by Treponema pallidum. J Clin Microbiol. 2003 Aug; 41(8):3668-74. PMID: 12904373.
      View in: PubMed
    148. Van Voorhis WC, Barrett LK, Eastman RT, Alfonso R, Dupuis K. Trypanosoma cruzi inactivation in human platelet concentrates and plasma by a psoralen (amotosalen HCl) and long-wavelength UV. Antimicrob Agents Chemother. 2003 Feb; 47(2):475-9. PMID: 12543646.
      View in: PubMed
    149. Gelb MH, Van Voorhis WC, Buckner FS, Yokoyama K, Eastman R, Carpenter EP, Panethymitaki C, Brown KA, Smith DF. Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics. Mol Biochem Parasitol. 2003 Feb; 126(2):155-63. PMID: 12615314.
      View in: PubMed
    150. Morgan CA, Lukehart SA, Van Voorhis WC. Immunization with the N-terminal portion of Treponema pallidum repeat protein K attenuates syphilitic lesion development in the rabbit model. Infect Immun. 2002 Dec; 70(12):6811-6. PMID: 12438357.
      View in: PubMed
    151. Buckner FS, Kateete DP, Lubega GW, Van Voorhis WC, Yokoyama K. Trypanosoma brucei prenylated-protein carboxyl methyltransferase prefers farnesylated substrates. Biochem J. 2002 Nov 01; 367(Pt 3):809-16. PMID: 12141948.
      View in: PubMed
    152. Clerici F, Gelmi ML, Yokoyama K, Pocar D, Van Voorhis WC, Buckner FS, Gelb MH. Isothiazole dioxides: synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase. Bioorg Med Chem Lett. 2002 Aug 19; 12(16):2217-20. PMID: 12127541.
      View in: PubMed
    153. Morgan CA, Molini BJ, Lukehart SA, Van Voorhis WC. Segregation of B and T cell epitopes of Treponema pallidum repeat protein K to variable and conserved regions during experimental syphilis infection. J Immunol. 2002 Jul 15; 169(2):952-7. PMID: 12097401.
      View in: PubMed
    154. Buckner FS, Eastman RT, Nepomuceno-Silva JL, Speelmon EC, Myler PJ, Van Voorhis WC, Yokoyama K. Cloning, heterologous expression, and substrate specificities of protein farnesyltransferases from Trypanosoma cruzi and Leishmania major. Mol Biochem Parasitol. 2002 Jul; 122(2):181-8. PMID: 12106872.
      View in: PubMed
    155. Gottlieb GS, Limaye AP, Chen YC, Van Voorhis WC. Candida dubliniensis fungemia in a solid organ transplant patient: case report and review of the literature. Med Mycol. 2001 Dec; 39(6):483-5. PMID: 11798053.
      View in: PubMed
    156. Bressi JC, Verlinde CL, Aronov AM, Shaw ML, Shin SS, Nguyen LN, Suresh S, Buckner FS, Van Voorhis WC, Kuntz ID, Hol WG, Gelb MH. Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design. J Med Chem. 2001 Jun 21; 44(13):2080-93. PMID: 11405646.
      View in: PubMed
    157. Manning-Cela R, Cortés A, González-Rey E, Van Voorhis WC, Swindle J, González A. LYT1 protein is required for efficient in vitro infection by Trypanosoma cruzi. Infect Immun. 2001 Jun; 69(6):3916-23. PMID: 11349059.
      View in: PubMed
    158. Nepomuceno-Silva JL, Yokoyama K, de Mello LD, Mendonca SM, Paixão JC, Baron R, Faye JC, Buckner FS, Van Voorhis WC, Gelb MH, Lopes UG. TcRho1, a farnesylated Rho family homologue from Trypanosoma cruzi: cloning, trans-splicing, and prenylation studies. J Biol Chem. 2001 Aug 10; 276(32):29711-8. PMID: 11359782.
      View in: PubMed
    159. Buckner FS, Griffin JH, Wilson AJ, Van Voorhis WC. Potent anti-Trypanosoma cruzi activities of oxidosqualene cyclase inhibitors. Antimicrob Agents Chemother. 2001 Apr; 45(4):1210-5. PMID: 11257036.
      View in: PubMed
    160. Bressi JC, Choe J, Hough MT, Buckner FS, Van Voorhis WC, Verlinde CL, Hol WG, Gelb MH. Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine. J Med Chem. 2000 Nov 02; 43(22):4135-50. PMID: 11063610.
      View in: PubMed
    161. Buckner FS, Yokoyama K, Nguyen L, Grewal A, Erdjument-Bromage H, Tempst P, Strickland CL, Xiao L, Van Voorhis WC, Gelb MH. Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei. J Biol Chem. 2000 Jul 21; 275(29):21870-6. PMID: 10749864.
      View in: PubMed
    162. Cameron CE, Lukehart SA, Castro C, Molini B, Godornes C, Van Voorhis WC. Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92. J Infect Dis. 2000 Apr; 181(4):1401-13. PMID: 10762571.
      View in: PubMed
    163. Centurion-Lara A, Sun ES, Barrett LK, Castro C, Lukehart SA, Van Voorhis WC. Multiple alleles of Treponema pallidum repeat gene D in Treponema pallidum isolates. J Bacteriol. 2000 Apr; 182(8):2332-5. PMID: 10735882.
      View in: PubMed
    164. Centurion-Lara A, Godornes C, Castro C, Van Voorhis WC, Lukehart SA. The tprK gene is heterogeneous among Treponema pallidum strains and has multiple alleles. Infect Immun. 2000 Feb; 68(2):824-31. PMID: 10639452.
      View in: PubMed
    165. Arroll TW, Centurion-Lara A, Lukehart SA, Van Voorhis WC. T-Cell responses to Treponema pallidum subsp. pallidum antigens during the course of experimental syphilis infection. Infect Immun. 1999 Sep; 67(9):4757-63. PMID: 10456928.
      View in: PubMed
    166. Weston D, La Flamme AC, Van Voorhis WC. Expression of Trypanosoma cruzi surface antigen FL-160 is controlled by elements in the 3' untranslated, the 3' intergenic, and the coding regions. Mol Biochem Parasitol. 1999 Jul 30; 102(1):53-66. PMID: 10477176.
      View in: PubMed
    167. Cameron CE, Castro C, Lukehart SA, Van Voorhis WC. Sequence conservation of glycerophosphodiester phosphodiesterase among Treponema pallidum strains. Infect Immun. 1999 Jun; 67(6):3168-70. PMID: 10338539.
      View in: PubMed
    168. Aronov AM, Suresh S, Buckner FS, Van Voorhis WC, Verlinde CL, Opperdoes FR, Hol WG, Gelb MH. Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase. Proc Natl Acad Sci U S A. 1999 Apr 13; 96(8):4273-8. PMID: 10200252.
      View in: PubMed
    169. Centurion-Lara A, Castro C, Barrett L, Cameron C, Mostowfi M, Van Voorhis WC, Lukehart SA. Treponema pallidum major sheath protein homologue Tpr K is a target of opsonic antibody and the protective immune response. J Exp Med. 1999 Feb 15; 189(4):647-56. PMID: 9989979.
      View in: PubMed
    170. Weston D, Patel B, Van Voorhis WC. Virulence in Trypanosoma cruzi infection correlates with the expression of a distinct family of sialidase superfamily genes. Mol Biochem Parasitol. 1999 Jan 05; 98(1):105-16. PMID: 10029313.
      View in: PubMed
    171. Buckner FS, Wilson AJ, Van Voorhis WC. Detection of live Trypanosoma cruzi in tissues of infected mice by using histochemical stain for beta-galactosidase. Infect Immun. 1999 Jan; 67(1):403-9. PMID: 9864242.
      View in: PubMed
    172. Buckner FS, Wilson AJ, White TC, Van Voorhis WC. Induction of resistance to azole drugs in Trypanosoma cruzi. Antimicrob Agents Chemother. 1998 Dec; 42(12):3245-50. PMID: 9835521.
      View in: PubMed
    173. Cameron CE, Castro C, Lukehart SA, Van Voorhis WC. Function and protective capacity of Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase. Infect Immun. 1998 Dec; 66(12):5763-70. PMID: 9826352.
      View in: PubMed
    174. Yokoyama K, Trobridge P, Buckner FS, Van Voorhis WC, Stuart KD, Gelb MH. Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kda subunits as a new target for antiparasite therapeutics. J Biol Chem. 1998 Oct 09; 273(41):26497-505. PMID: 9756885.
      View in: PubMed
    175. Yokoyama K, Trobridge P, Buckner FS, Scholten J, Stuart KD, Van Voorhis WC, Gelb MH. The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth. Mol Biochem Parasitol. 1998 Jul 01; 94(1):87-97. PMID: 9719512.
      View in: PubMed
    176. Centurion-Lara A, Castro C, Castillo R, Shaffer JM, Van Voorhis WC, Lukehart SA. The flanking region sequences of the 15-kDa lipoprotein gene differentiate pathogenic treponemes. J Infect Dis. 1998 Apr; 177(4):1036-40. PMID: 9534979.
      View in: PubMed
    177. La Flamme AC, Kahn SJ, Rudensky AY, Van Voorhis WC. Trypanosoma cruzi-infected macrophages are defective in major histocompatibility complex class II antigen presentation. Eur J Immunol. 1997 Dec; 27(12):3085-94. PMID: 9464791.
      View in: PubMed
    178. Buckner FS, Wipke BT, Van Voorhis WC. Trypanosoma cruzi infection does not impair major histocompatibility complex class I presentation of antigen to cytotoxic T lymphocytes. Eur J Immunol. 1997 Oct; 27(10):2541-8. PMID: 9368608.
      View in: PubMed
    179. Stebeck CE, Shaffer JM, Arroll TW, Lukehart SA, Van Voorhis WC. Identification of the Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase homologue. FEMS Microbiol Lett. 1997 Sep 15; 154(2):303-10. PMID: 9311129.
      View in: PubMed
    180. Buckner FS, Wilson AJ, Van Voorhis WC. Trypanosoma cruzi: use of herpes simplex virus-thymidine kinase as a negative selectable marker. Exp Parasitol. 1997 Jul; 86(3):171-80. PMID: 9225767.
      View in: PubMed
    181. Van Voorhis WC, Barrett LK, Sweeney YT, Kuo CC, Patton DL. Repeated Chlamydia trachomatis infection of Macaca nemestrina fallopian tubes produces a Th1-like cytokine response associated with fibrosis and scarring. Infect Immun. 1997 Jun; 65(6):2175-82. PMID: 9169748.
      View in: PubMed
    182. Centurion-Lara A, Castro C, Shaffer JM, Van Voorhis WC, Marra CM, Lukehart SA. Detection of Treponema pallidum by a sensitive reverse transcriptase PCR. J Clin Microbiol. 1997 Jun; 35(6):1348-52. PMID: 9163442.
      View in: PubMed
    183. Centurion-Lara A, Arroll T, Castillo R, Shaffer JM, Castro C, Van Voorhis WC, Lukehart SA. Conservation of the 15-kilodalton lipoprotein among Treponema pallidum subspecies and strains and other pathogenic treponemes: genetic and antigenic analyses. Infect Immun. 1997 Apr; 65(4):1440-4. PMID: 9119485.
      View in: PubMed
    184. Buckner FS, Verlinde CL, La Flamme AC, Van Voorhis WC. Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase. Antimicrob Agents Chemother. 1996 Nov; 40(11):2592-7. PMID: 8913471.
      View in: PubMed
    185. Centurion-Lara A, Castro C, van Voorhis WC, Lukehart SA. Two 16S-23S ribosomal DNA intergenic regions in different Treponema pallidum subspecies contain tRNA genes. FEMS Microbiol Lett. 1996 Oct 01; 143(2-3):235-40. PMID: 8837477.
      View in: PubMed
    186. Van Voorhis WC, Barrett LK, Sweeney YT, Kuo CC, Patton DL. Analysis of lymphocyte phenotype and cytokine activity in the inflammatory infiltrates of the upper genital tract of female macaques infected with Chlamydia trachomatis. J Infect Dis. 1996 Sep; 174(3):647-50. PMID: 8769630.
      View in: PubMed
    187. La Flamme AC, Buckner FS, Swindle J, Ajioka J, Van Voorhis WC. Trypanosoma cruzi: expression of interleukin-2 utilizing both supercoiled plasmids and linear DNAs. Exp Parasitol. 1996 Jun; 83(1):159-63. PMID: 8654546.
      View in: PubMed
    188. van Voorhis WC, Barrett LK, Nasio JM, Plummer FA, Lukehart SA. Lesions of primary and secondary syphilis contain activated cytolytic T cells. Infect Immun. 1996 Mar; 64(3):1048-50. PMID: 8641758.
      View in: PubMed
    189. Oliver MR, Van Voorhis WC, Boeckh M, Mattson D, Bowden RA. Hepatic mucormycosis in a bone marrow transplant recipient who ingested naturopathic medicine. Clin Infect Dis. 1996 Mar; 22(3):521-4. PMID: 8852973.
      View in: PubMed
    190. Van Voorhis WC, Barrett LK, Koelle DM, Nasio JM, Plummer FA, Lukehart SA. Primary and secondary syphilis lesions contain mRNA for Th1 cytokines. J Infect Dis. 1996 Feb; 173(2):491-5. PMID: 8568320.
      View in: PubMed
    191. Liles WC, Van Voorhis WC. Review: nomenclature and biologic significance of cytokines involved in inflammation and the host immune response. J Infect Dis. 1995 Dec; 172(6):1573-80. PMID: 7594719.
      View in: PubMed
    192. La Flamme AC, Buckner FS, Swindle J, Ajioka J, Van Voorhis WC. Expression of mammalian cytokines by Trypanosoma cruzi indicates unique signal sequence requirements and processing. Mol Biochem Parasitol. 1995 Dec; 75(1):25-31. PMID: 8720172.
      View in: PubMed
    193. Van Voorhis WC, Pham VT, De Vos T. The FL-160 genes of Trypanosoma cruzi are dispersed on multiple chromosomes. Exp Parasitol. 1995 May; 80(3):578-82. PMID: 7729494.
      View in: PubMed
    194. Centurion-Lara A, Barrett L, Van Voorhis WC. Quantitation of parasitemia by competitive polymerase chain reaction amplification of parasite kDNA minicircles during chronic infection with Trypanosoma cruzi. J Infect Dis. 1994 Nov; 170(5):1334-9. PMID: 7963741.
      View in: PubMed
    195. Klebanoff SJ, Kazazi F, Van Voorhis WC, Schlechte KG. Activation of the human immunodeficiency virus long terminal repeat in THP-1 cells by a staphylococcal extracellular product. Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10615-9. PMID: 7938001.
      View in: PubMed
    196. La Flamme AC, Buckner F, Swindle J, Ajioka J, Barrett L, Van Voorhis WC. Engineering cytokine secretion from Trypanosoma cruzi. Mem Inst Oswaldo Cruz. 1994 Oct-Dec; 89(4):650-1. PMID: 8524068.
      View in: PubMed
    197. Cetron MS, Basilio FP, Moraes AP, Sousa AQ, Paes JN, Kahn SJ, Wener MH, Van Voorhis WC. Humoral and cellular immune response of adults from northeastern Brazil with chronic Trypanosoma cruzi infection: depressed cellular immune response to T. cruzi antigen among Chagas' disease patients with symptomatic versus indeterminate infection. Am J Trop Med Hyg. 1993 Sep; 49(3):370-82. PMID: 8372959.
      View in: PubMed
    198. Van Voorhis WC, Barrett L, Koelling R, Farr AG. FL-160 proteins of Trypanosoma cruzi are expressed from a multigene family and contain two distinct epitopes that mimic nervous tissues. J Exp Med. 1993 Aug 01; 178(2):681-94. PMID: 7688032.
      View in: PubMed
    199. Kahn S, Kahn M, van Voorhis WC, Goshorn A, Strand A, Hoagland N, Eisen H, Pennathur S. SA85-1 proteins of Trypanosoma cruzi lack sialidase activity. Mol Biochem Parasitol. 1993 Jul; 60(1):149-52. PMID: 8366889.
      View in: PubMed
    200. Klebanoff SJ, Olszowski S, Van Voorhis WC, Ledbetter JA, Waltersdorph AM, Schlechte KG. Effects of gamma-interferon on human neutrophils: protection from deterioration on storage. Blood. 1992 Jul 01; 80(1):225-34. PMID: 1319236.
      View in: PubMed
    201. Cetron MS, Hoff R, Kahn S, Eisen H, Van Voorhis WC. Evaluation of recombinant trypomastigote surface antigens of Trypanosoma cruzi in screening sera from a population in rural northeastern Brazil endemic for Chagas' disease. Acta Trop. 1992 Feb; 50(3):259-66. PMID: 1348602.
      View in: PubMed
    202. Van Voorhis WC. Coculture of human peripheral blood mononuclear cells with Trypanosoma cruzi leads to proliferation of lymphocytes and cytokine production. J Immunol. 1992 Jan 01; 148(1):239-48. PMID: 1727869.
      View in: PubMed
    203. Van Voorhis WC, Schlekewy L, Trong HL. Molecular mimicry by Trypanosoma cruzi: the F1-160 epitope that mimics mammalian nerve can be mapped to a 12-amino acid peptide. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):5993-7. PMID: 1712477.
      View in: PubMed
    204. Petry K, Van Voorhis WC. Antigens of Trypanosoma cruzi that mimic mammalian nervous tissues: investigations of their role in the autoimmune pathophysiology of chronic Chagas' disease. Res Immunol. 1991 Feb; 142(2):151-6. PMID: 1714088.
      View in: PubMed
    205. Kahn S, Van Voorhis WC, Eisen H. The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi is encoded by a large heterogeneous family of simultaneously expressed genes. J Exp Med. 1990 Aug 01; 172(2):589-97. PMID: 1695668.
      View in: PubMed
    206. Van Voorhis WC. Therapy and prophylaxis of systemic protozoan infections. Drugs. 1990 Aug; 40(2):176-202. PMID: 2121456.
      View in: PubMed
    207. Van Voorhis WC, Eisen H. Fl-160. A surface antigen of Trypanosoma cruzi that mimics mammalian nervous tissue. J Exp Med. 1989 Mar 01; 169(3):641-52. PMID: 2466939.
      View in: PubMed
    208. Van Voorhis WC, Witmer MD, Steinman RM. The phenotype of dendritic cells and macrophages. Fed Proc. 1983 Nov; 42(14):3114-8. PMID: 6628701.
      View in: PubMed
    209. Inaba K, Steinman RM, Van Voorhis WC, Muramatsu S. Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man. Proc Natl Acad Sci U S A. 1983 Oct; 80(19):6041-5. PMID: 6351074.
      View in: PubMed
    210. Kaplan G, Van Voorhis WC, Sarno EN, Nogueira N, Cohn ZA. The cutaneous infiltrates of leprosy. A transmission electron microscopy study. J Exp Med. 1983 Oct 01; 158(4):1145-59. PMID: 6352848.
      View in: PubMed
    211. Wright SD, Rao PE, Van Voorhis WC, Craigmyle LS, Iida K, Talle MA, Westberg EF, Goldstein G, Silverstein SC. Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies. Proc Natl Acad Sci U S A. 1983 Sep; 80(18):5699-703. PMID: 6225125.
      View in: PubMed
    212. Van Voorhis WC, Steinman RM, Hair LS, Luban J, Witmer MD, Koide S, Cohn ZA. Specific antimononuclear phagocyte monoclonal antibodies. Application to the purification of dendritic cells and the tissue localization of macrophages. J Exp Med. 1983 Jul 01; 158(1):126-45. PMID: 6190974.
      View in: PubMed
    213. Van Voorhis WC, Valinsky J, Hoffman E, Luban J, Hair LS, Steinman RM. Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication. J Exp Med. 1983 Jul 01; 158(1):174-91. PMID: 6190976.
      View in: PubMed
    214. Van Voorhis WC, Kaplan G, Sarno EN, Horwitz MA, Steinman RM, Levis WR, Nogueira N, Hair LS, Gattass CR, Arrick BA, Cohn ZA. The cutaneous infiltrates of leprosy: cellular characteristics and the predominant T-cell phenotypes. N Engl J Med. 1982 Dec 23; 307(26):1593-7. PMID: 6216407.
      View in: PubMed
    215. Van Voorhis WC, Hair LS, Steinman RM, Kaplan G. Human dendritic cells. Enrichment and characterization from peripheral blood. J Exp Med. 1982 Apr 01; 155(4):1172-87. PMID: 6460832.
      View in: PubMed
    216. Baker RM, Van Voorhis WC, Spencer LA. HeLa cell variants that differ in sensitivity to monofunctional alkylating agents, with independence of cytotoxic and mutagenic responses. Proc Natl Acad Sci U S A. 1979 Oct; 76(10):5249-53. PMID: 291942.
      View in: PubMed
    Van Voorhis's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description