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Professor Emeritus George Alan Martin Cross

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mugnier MR, Cross GA, Papavasiliou FN. The in vivo dynamics of antigenic variation in Trypanosoma brucei. Science. 2015 Mar 27; 347(6229):1470-3. PMID: 25814582; PMCID: PMC4514441.
    2. Cross GA, Kim HS, Wickstead B. Capturing the variant surface glycoprotein repertoire (the VSGnome) of Trypanosoma brucei Lister 427. Mol Biochem Parasitol. 2014 Jun; 195(1):59-73. PMID: 24992042.
      View in: PubMed
    3. Kim HS, Li Z, Boothroyd C, Cross GA. Strategies to construct null and conditional null Trypanosoma brucei mutants using Cre-recombinase and loxP. Mol Biochem Parasitol. 2013 Sep; 191(1):16-9. PMID: 23954366; PMCID: PMC3830529.
    4. Kim HS, Park SH, Günzl A, Cross GA. MCM-BP is required for repression of life-cycle specific genes transcribed by RNA polymerase I in the mammalian infectious form of Trypanosoma brucei. PLoS One. 2013; 8(2):e57001. PMID: 23451133; PMCID: PMC3581582.
    5. Benmerzouga I, Concepción-Acevedo J, Kim HS, Vandoros AV, Cross GA, Klingbeil MM, Li B. Trypanosoma brucei Orc1 is essential for nuclear DNA replication and affects both VSG silencing and VSG switching. Mol Microbiol. 2013 Jan; 87(1):196-210. PMID: 23216794; PMCID: PMC3535549.
    6. Kolev NG, Ramey-Butler K, Cross GA, Ullu E, Tschudi C. Developmental progression to infectivity in Trypanosoma brucei triggered by an RNA-binding protein. Science. 2012 Dec 07; 338(6112):1352-3. PMID: 23224556; PMCID: PMC3664091.
    7. Hovel-Miner GA, Boothroyd CE, Mugnier M, Dreesen O, Cross GA, Papavasiliou FN. Telomere length affects the frequency and mechanism of antigenic variation in Trypanosoma brucei. PLoS Pathog. 2012; 8(8):e1002900. PMID: 22952449; PMCID: PMC3431348.
    8. Kim HS, Cross GA. Identification of Trypanosoma brucei RMI1/BLAP75 homologue and its roles in antigenic variation. PLoS One. 2011; 6(9):e25313. PMID: 21980422; PMCID: PMC3182221.
    9. Siegel TN, Gunasekera K, Cross GA, Ochsenreiter T. Gene expression in Trypanosoma brucei: lessons from high-throughput RNA sequencing. Trends Parasitol. 2011 Oct; 27(10):434-41. PMID: 21737348; PMCID: PMC3178736.
    10. Kim HS, Cross GA. TOPO3alpha influences antigenic variation by monitoring expression-site-associated VSG switching in Trypanosoma brucei. PLoS Pathog. 2010 Jul 08; 6(7):e1000992. PMID: 20628569; PMCID: PMC2900300.
    11. Siegel TN, Hekstra DR, Wang X, Dewell S, Cross GA. Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. Nucleic Acids Res. 2010 Aug; 38(15):4946-57. PMID: 20385579; PMCID: PMC2926603.
    12. Cross GA. Drug discovery: Fat-free proteins kill parasites. Nature. 2010 Apr 01; 464(7289):689-90. PMID: 20360728.
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    13. Wright JR, Siegel TN, Cross GA. Histone H3 trimethylated at lysine 4 is enriched at probable transcription start sites in Trypanosoma brucei. Mol Biochem Parasitol. 2010 Aug; 172(2):141-4. PMID: 20347883; PMCID: PMC2875994.
    14. Cliffe LJ, Siegel TN, Marshall M, Cross GA, Sabatini R. Two thymidine hydroxylases differentially regulate the formation of glucosylated DNA at regions flanking polymerase II polycistronic transcription units throughout the genome of Trypanosoma brucei. Nucleic Acids Res. 2010 Jul; 38(12):3923-35. PMID: 20215442; PMCID: PMC2896530.
    15. Figueiredo LM, Cross GA. Nucleosomes are depleted at the VSG expression site transcribed by RNA polymerase I in African trypanosomes. Eukaryot Cell. 2010 Jan; 9(1):148-54. PMID: 19915072; PMCID: PMC2805297.
    16. Figueiredo LM, Cross GA, Janzen CJ. Epigenetic regulation in African trypanosomes: a new kid on the block. Nat Rev Microbiol. 2009 Jul; 7(7):504-13. PMID: 19528957.
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    17. Boothroyd CE, Dreesen O, Leonova T, Ly KI, Figueiredo LM, Cross GA, Papavasiliou FN. A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma brucei. Nature. 2009 May 14; 459(7244):278-81. PMID: 19369939; PMCID: PMC2688456.
    18. Siegel TN, Hekstra DR, Kemp LE, Figueiredo LM, Lowell JE, Fenyo D, Wang X, Dewell S, Cross GA. Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei. Genes Dev. 2009 May 01; 23(9):1063-76. PMID: 19369410; PMCID: PMC2682952.
    19. Hertz-Fowler C, Figueiredo LM, Quail MA, Becker M, Jackson A, Bason N, Brooks K, Churcher C, Fahkro S, Goodhead I, Heath P, Kartvelishvili M, Mungall K, Harris D, Hauser H, Sanders M, Saunders D, Seeger K, Sharp S, Taylor JE, Walker D, White B, Young R, Cross GA, Rudenko G, Barry JD, Louis EJ, Berriman M. Telomeric expression sites are highly conserved in Trypanosoma brucei. PLoS One. 2008; 3(10):e3527. PMID: 18953401; PMCID: PMC2567434.
    20. Figueiredo LM, Janzen CJ, Cross GA. A histone methyltransferase modulates antigenic variation in African trypanosomes. PLoS Biol. 2008 Jul 01; 6(7):e161. PMID: 18597556; PMCID: PMC2443197.
    21. Siegel TN, Hekstra DR, Cross GA. Analysis of the Trypanosoma brucei cell cycle by quantitative DAPI imaging. Mol Biochem Parasitol. 2008 Aug; 160(2):171-4. PMID: 18501977; PMCID: PMC2495048.
    22. Mandava V, Janzen CJ, Cross GA. Trypanosome H2Bv replaces H2B in nucleosomes enriched for H3 K4 and K76 trimethylation. Biochem Biophys Res Commun. 2008 Apr 18; 368(4):846-51. PMID: 18261990; PMCID: PMC2276873.
    23. Siegel TN, Kawahara T, Degrasse JA, Janzen CJ, Horn D, Cross GA. Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in Trypanosoma brucei. Mol Microbiol. 2008 Feb; 67(4):762-71. PMID: 18179414; PMCID: PMC2253726.
    24. Scahill MD, Pastar I, Cross GA. CRE recombinase-based positive-negative selection systems for genetic manipulation in Trypanosoma brucei. Mol Biochem Parasitol. 2008 Jan; 157(1):73-82. PMID: 18006158; PMCID: PMC2211722.
    25. Dreesen O, Cross GA. Telomere length in Trypanosoma brucei. Exp Parasitol. 2008 Jan; 118(1):103-10. PMID: 17910953; PMCID: PMC2233935.
    26. Mandava V, Fernandez JP, Deng H, Janzen CJ, Hake SB, Cross GA. Histone modifications in Trypanosoma brucei. Mol Biochem Parasitol. 2007 Nov; 156(1):41-50. PMID: 17714803; PMCID: PMC2012948.
    27. Dreesen O, Li B, Cross GA. Telomere structure and function in trypanosomes: a proposal. Nat Rev Microbiol. 2007 01; 5(1):70-5. PMID: 17160000.
      View in: PubMed
    28. Dreesen O, Cross GA. Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei. Eukaryot Cell. 2006 Dec; 5(12):2114-9. PMID: 17071826; PMCID: PMC1694812.
    29. Janzen CJ, Hake SB, Lowell JE, Cross GA. Selective di- or trimethylation of histone H3 lysine 76 by two DOT1 homologs is important for cell cycle regulation in Trypanosoma brucei. Mol Cell. 2006 Aug; 23(4):497-507. PMID: 16916638.
      View in: PubMed
    30. Dreesen O, Cross GA. Telomerase-independent stabilization of short telomeres in Trypanosoma brucei. Mol Cell Biol. 2006 Jul; 26(13):4911-9. PMID: 16782879; PMCID: PMC1489180.
    31. Janzen CJ, van Deursen F, Shi H, Cross GAM, Matthews KR, Ullu E. Expression site silencing and life-cycle progression appear normal in Argonaute1-deficient Trypanosoma brucei. Mol Biochem Parasitol. 2006 Sep; 149(1):102-107. PMID: 16735068; PMCID: PMC3904126.
    32. Janzen CJ, Fernandez JP, Deng H, Diaz R, Hake SB, Cross GA. Unusual histone modifications in Trypanosoma brucei. FEBS Lett. 2006 Apr 17; 580(9):2306-10. PMID: 16580668.
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    33. Lowell JE, Kaiser F, Janzen CJ, Cross GA. Histone H2AZ dimerizes with a novel variant H2B and is enriched at repetitive DNA in Trypanosoma brucei. J Cell Sci. 2005 Dec 15; 118(Pt 24):5721-30. PMID: 16303849.
      View in: PubMed
    34. Siegel TN, Tan KS, Cross GA. Systematic study of sequence motifs for RNA trans splicing in Trypanosoma brucei. Mol Cell Biol. 2005 Nov; 25(21):9586-94. PMID: 16227607; PMCID: PMC1265811.
    35. Gopal S, Awadalla S, Gaasterland T, Cross GA. A computational investigation of kinetoplastid trans-splicing. Genome Biol. 2005; 6(11):R95. PMID: 16277750; PMCID: PMC1297651.
    36. Dreesen O, Li B, Cross GA. Telomere structure and shortening in telomerase-deficient Trypanosoma brucei. Nucleic Acids Res. 2005; 33(14):4536-43. PMID: 16091631; PMCID: PMC1184224.
    37. Cross GA. Trypanosomes at the gates. Science. 2005 Jul 15; 309(5733):355. PMID: 16020696.
      View in: PubMed
    38. Li B, Espinal A, Cross GA. Trypanosome telomeres are protected by a homologue of mammalian TRF2. Mol Cell Biol. 2005 Jun; 25(12):5011-21. PMID: 15923618; PMCID: PMC1140576.
    39. Lowell JE, Cross GA. A variant histone H3 is enriched at telomeres in Trypanosoma brucei. J Cell Sci. 2004 Nov 15; 117(Pt 24):5937-47. PMID: 15522895.
      View in: PubMed
    40. Leal S, Acosta-Serrano A, Morris J, Cross GA. Transposon mutagenesis of Trypanosoma brucei identifies glycosylation mutants resistant to concanavalin A. J Biol Chem. 2004 Jul 09; 279(28):28979-88. PMID: 15123607.
      View in: PubMed
    41. Gopal S, Cross GA, Gaasterland T. An organism-specific method to rank predicted coding regions in Trypanosoma brucei. Nucleic Acids Res. 2003 Oct 15; 31(20):5877-85. PMID: 14530436; PMCID: PMC219476.
    42. Wang J, Böhme U, Cross GA. Structural features affecting variant surface glycoprotein expression in Trypanosoma brucei. Mol Biochem Parasitol. 2003 May; 128(2):135-45. PMID: 12742580.
      View in: PubMed
    43. Tan KS, Leal ST, Cross GA. Trypanosoma brucei MRE11 is non-essential but influences growth, homologous recombination and DNA double-strand break repair. Mol Biochem Parasitol. 2002 Nov-Dec; 125(1-2):11-21. PMID: 12467970.
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    44. Berriman M, Hall N, Sheader K, Bringaud F, Tiwari B, Isobe T, Bowman S, Corton C, Clark L, Cross GA, Hoek M, Zanders T, Berberof M, Borst P, Rudenko G. The architecture of variant surface glycoprotein gene expression sites in Trypanosoma brucei. Mol Biochem Parasitol. 2002 Jul; 122(2):131-40. PMID: 12106867.
      View in: PubMed
    45. Hoek M, Zanders T, Cross GA. Trypanosoma brucei expression-site-associated-gene-8 protein interacts with a Pumilio family protein. Mol Biochem Parasitol. 2002 Apr 09; 120(2):269-83. PMID: 11897132.
      View in: PubMed
    46. Böhme U, Cross GA. Mutational analysis of the variant surface glycoprotein GPI-anchor signal sequence in Trypanosoma brucei. J Cell Sci. 2002 Feb 15; 115(Pt 4):805-16. PMID: 11865036.
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    47. Cross GA. African trypanosomes in the 21st century: what is their future in science and in health? Int J Parasitol. 2001 May 01; 31(5-6):427-33. PMID: 11334926.
      View in: PubMed
    48. Clayton C, Adams M, Almeida R, Baltz T, Barrett M, Bastien P, Belli S, Beverley S, Biteau N, Blackwell J, Blaineau C, Boshart M, Bringaud F, Cross G, Cruz A, Degrave W, Donelson J, El-Sayed N, Fu G, Ersfeld K, Gibson W, Gull K, Ivens A, Kelly J, Vanhamme L, et al. Genetic nomenclature for Trypanosoma and Leishmania. Mol Biochem Parasitol. 1998 Nov 30; 97(1-2):221-4. PMID: 9879900.
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