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Professor Thomas Seebeck

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jansen C, Wang H, Kooistra AJ, de Graaf C, Orrling KM, Tenor H, Seebeck T, Bailey D, de Esch IJ, Ke H, Leurs R. Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure. J Med Chem. 2013 Mar 14; 56(5):2087-96. PMID: 23409953; PMCID: PMC3635145.
    2. Orrling KM, Jansen C, Vu XL, Balmer V, Bregy P, Shanmugham A, England P, Bailey D, Cos P, Maes L, Adams E, van den Bogaart E, Chatelain E, Ioset JR, van de Stolpe A, Zorg S, Veerman J, Seebeck T, Sterk GJ, de Esch IJ, Leurs R. Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase B1. J Med Chem. 2012 Oct 25; 55(20):8745-56. PMID: 22963052.
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    3. Kuhn-Nentwig L, Fedorova IM, Lüscher BP, Kopp LS, Trachsel C, Schaller J, Vu XL, Seebeck T, Streitberger K, Nentwig W, Sigel E, Magazanik LG. A venom-derived neurotoxin, CsTx-1, from the spider Cupiennius salei exhibits cytolytic activities. J Biol Chem. 2012 Jul 20; 287(30):25640-9. PMID: 22613721; PMCID: PMC3408166.
    4. Wang H, Kunz S, Chen G, Seebeck T, Wan Y, Robinson H, Martinelli S, Ke H. Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors. J Biol Chem. 2012 Apr 06; 287(15):11788-97. PMID: 22356915; PMCID: PMC3320927.
    5. de Koning HP, Gould MK, Sterk GJ, Tenor H, Kunz S, Luginbuehl E, Seebeck T. Pharmacological validation of Trypanosoma brucei phosphodiesterases as novel drug targets. J Infect Dis. 2012 Jul 15; 206(2):229-37. PMID: 22291195; PMCID: PMC3379837.
    6. Seebeck T, Sterk GJ, Ke H. Phosphodiesterase inhibitors as a new generation of antiprotozoan drugs: exploiting the benefit of enzymes that are highly conserved between host and parasite. Future Med Chem. 2011 Aug; 3(10):1289-306. PMID: 21859303; PMCID: PMC3164761.
    7. Luginbuehl E, Kunz S, Wentzinger L, Freimoser F, Seebeck T. The exopolyphosphatase TbrPPX1 of Trypanosoma brucei. BMC Microbiol. 2011 Jan 06; 11:4. PMID: 21208463; PMCID: PMC3022644.
    8. Shakur Y, de Koning HP, Ke H, Kambayashi J, Seebeck T. Therapeutic potential of phosphodiesterase inhibitors in parasitic diseases. Handb Exp Pharmacol. 2011; (204):487-510. PMID: 21695653.
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    9. Cristodero M, Seebeck T, Schneider A. Mitochondrial translation is essential in bloodstream forms of Trypanosoma brucei. Mol Microbiol. 2010 Nov; 78(3):757-69. PMID: 20969649.
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    10. Luginbuehl E, Ryter D, Schranz-Zumkehr J, Oberholzer M, Kunz S, Seebeck T. The N terminus of phosphodiesterase TbrPDEB1 of Trypanosoma brucei contains the signal for integration into the flagellar skeleton. Eukaryot Cell. 2010 Oct; 9(10):1466-75. PMID: 20693305; PMCID: PMC2950416.
    11. Kuhn-Nentwig L, Willems J, Seebeck T, Shalaby T, Kaiser M, Nentwig W. Cupiennin 1a exhibits a remarkably broad, non-stereospecific cytolytic activity on bacteria, protozoan parasites, insects, and human cancer cells. Amino Acids. 2011 Jan; 40(1):69-76. PMID: 20140690.
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    12. Kunz S, Luginbuehl E, Seebeck T. Gene conversion transfers the GAF-A domain of phosphodiesterase TbrPDEB1 to one allele of TbrPDEB2 of Trypanosoma brucei. PLoS Negl Trop Dis. 2009 Jun 09; 3(6):e455. PMID: 19513125; PMCID: PMC2689650.
    13. Gould MK, Vu XL, Seebeck T, de Koning HP. Propidium iodide-based methods for monitoring drug action in the kinetoplastidae: comparison with the Alamar Blue assay. Anal Biochem. 2008 Nov 15; 382(2):87-93. PMID: 18722997.
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    14. Wentzinger L, Bopp S, Tenor H, Klar J, Brun R, Beck HP, Seebeck T. Cyclic nucleotide-specific phosphodiesterases of Plasmodium falciparum: PfPDEalpha, a non-essential cGMP-specific PDE that is an integral membrane protein. Int J Parasitol. 2008 Dec; 38(14):1625-37. PMID: 18590734.
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    15. Wang H, Yan Z, Geng J, Kunz S, Seebeck T, Ke H. Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors. Mol Microbiol. 2007 Nov; 66(4):1029-38. PMID: 17944832; PMCID: PMC2950065.
    16. Oberholzer M, Bregy P, Marti G, Minca M, Peier M, Seebeck T. Trypanosomes and mammalian sperm: one of a kind? Trends Parasitol. 2007 Feb; 23(2):71-7. PMID: 17174157.
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    17. Oberholzer M, Marti G, Baresic M, Kunz S, Hemphill A, Seebeck T. The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence. FASEB J. 2007 Mar; 21(3):720-31. PMID: 17167070.
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    18. Johner A, Kunz S, Linder M, Shakur Y, Seebeck T. Cyclic nucleotide specific phosphodiesterases of Leishmania major. BMC Microbiol. 2006 Mar 08; 6:25. PMID: 16522215; PMCID: PMC1431542.
    19. Kunz S, Oberholzer M, Seebeck T. A FYVE-containing unusual cyclic nucleotide phosphodiesterase from Trypanosoma cruzi. FEBS J. 2005 Dec; 272(24):6412-22. PMID: 16336277.
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    20. Alibu VP, Richter C, Voncken F, Marti G, Shahi S, Renggli CK, Seebeck T, Brun R, Clayton C. The role of Trypanosoma brucei MRPA in melarsoprol susceptibility. Mol Biochem Parasitol. 2006 Mar; 146(1):38-44. PMID: 16343658.
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    21. Kunz S, Beavo JA, D'Angelo MA, Flawia MM, Francis SH, Johner A, Laxman S, Oberholzer M, Rascon A, Shakur Y, Wentzinger L, Zoraghi R, Seebeck T. Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature. Mol Biochem Parasitol. 2006 Jan; 145(1):133-5. PMID: 16280178.
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    22. Oberholzer M, Morand S, Kunz S, Seebeck T. A vector series for rapid PCR-mediated C-terminal in situ tagging of Trypanosoma brucei genes. Mol Biochem Parasitol. 2006 Jan; 145(1):117-20. PMID: 16269191.
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    23. Geiser F, Lüscher A, de Koning HP, Seebeck T, Mäser P. Molecular pharmacology of adenosine transport in Trypanosoma brucei: P1/P2 revisited. Mol Pharmacol. 2005 Sep; 68(3):589-95. PMID: 15933219.
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    24. Seebeck T, Schaub R, Johner A. cAMP signalling in the kinetoplastid protozoa. Curr Mol Med. 2004 Sep; 4(6):585-99. PMID: 15357210.
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    25. Gadelha C, LeBowitz JH, Manning J, Seebeck T, Gull K. Relationships between the major kinetoplastid paraflagellar rod proteins: a consolidating nomenclature. Mol Biochem Parasitol. 2004 Jul; 136(1):113-5. PMID: 15138073.
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    26. Kunz S, Kloeckner T, Essen LO, Seebeck T, Boshart M. TbPDE1, a novel class I phosphodiesterase of Trypanosoma brucei. Eur J Biochem. 2004 Feb; 271(3):637-47. PMID: 14728691.
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    27. Matovu E, Stewart ML, Geiser F, Brun R, Mäser P, Wallace LJ, Burchmore RJ, Enyaru JC, Barrett MP, Kaminsky R, Seebeck T, de Koning HP. Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryot Cell. 2003 Oct; 2(5):1003-8. PMID: 14555482; PMCID: PMC219364.
    28. Viswambharan H, Seebeck T, Yang Z. Enhanced endothelial nitric oxide-synthase activity in mice infected with Trypanosoma brucei. Int J Parasitol. 2003 Sep 15; 33(10):1099-104. PMID: 13129532.
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    29. Zoraghi R, Seebeck T. The cAMP-specific phosphodiesterase TbPDE2C is an essential enzyme in bloodstream form Trypanosoma brucei. Proc Natl Acad Sci U S A. 2002 Apr 02; 99(7):4343-8. PMID: 11930001; PMCID: PMC123650.
    30. Shalaby T, Liniger M, Seebeck T. The regulatory subunit of a cGMP-regulated protein kinase A of Trypanosoma brucei. Eur J Biochem. 2001 Dec; 268(23):6197-206. PMID: 11733015.
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    31. Matovu E, Geiser F, Schneider V, Mäser P, Enyaru JC, Kaminsky R, Gallati S, Seebeck T. Genetic variants of the TbAT1 adenosine transporter from African trypanosomes in relapse infections following melarsoprol therapy. Mol Biochem Parasitol. 2001 Sep 28; 117(1):73-81. PMID: 11551633.
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    32. Gong KW, Kunz S, Zoraghi R, Kunz Renggli C, Brun R, Seebeck T. cAMP-specific phosphodiesterase TbPDE1 is not essential in Trypanosoma brucei in culture or during midgut infection of tsetse flies. Mol Biochem Parasitol. 2001 Sep 03; 116(2):229-32. PMID: 11522356.
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    33. Matovu E, Seebeck T, Enyaru JC, Kaminsky R. Drug resistance in Trypanosoma brucei spp., the causative agents of sleeping sickness in man and nagana in cattle. Microbes Infect. 2001 Jul; 3(9):763-70. PMID: 11489425.
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    34. Seebeck T, Gong K, Kunz S, Schaub R, Shalaby T, Zoraghi R. cAMP signalling in Trypanosoma brucei. Int J Parasitol. 2001 May 01; 31(5-6):491-8. PMID: 11334934.
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    35. Matovu E, Enyaru JC, Legros D, Schmid C, Seebeck T, Kaminsky R. Melarsoprol refractory T. b. gambiense from Omugo, north-western Uganda. Trop Med Int Health. 2001 May; 6(5):407-11. PMID: 11348535.
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    36. Naula C, Schaub R, Leech V, Melville S, Seebeck T. Spontaneous dimerization and leucine-zipper induced activation of the recombinant catalytic domain of a new adenylyl cyclase of Trypanosoma brucei, GRESAG4.4B. Mol Biochem Parasitol. 2001 Jan 15; 112(1):19-28. PMID: 11166383.
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    37. Zoraghi R, Kunz S, Gong K, Seebeck T. Characterization of TbPDE2A, a novel cyclic nucleotide-specific phosphodiesterase from the protozoan parasite Trypanosoma brucei. J Biol Chem. 2001 Apr 13; 276(15):11559-66. PMID: 11134002.
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    38. Hunger-Glaser I, Hemphill A, Shalaby T, Hänni M, Seebeck T. Nucleoside diphosphate kinase of Trypanosoma brucei. Gene. 2000 Oct 31; 257(2):251-7. PMID: 11080591.
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    39. Stoppini L, Buchs PA, Brun R, Muller D, Duport S, Parisi L, Seebeck T. Infection of organotypic slice cultures from rat central nervous tissue with Trypanosoma brucei brucei. Int J Med Microbiol. 2000 Mar; 290(1):105-13. PMID: 11043987.
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    40. Naula C, Seebeck T. Cyclic AMP signaling in trypanosomatids. Parasitol Today. 2000 Jan; 16(1):35-8. PMID: 10637587.
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    41. Bütikofer P, Vassella E, Ruepp S, Boschung M, Civenni G, Seebeck T, Hemphill A, Mookherjee N, Pearson TW, Roditi I. Phosphorylation of a major GPI-anchored surface protein of Trypanosoma brucei during transport to the plasma membrane. J Cell Sci. 1999 Jun; 112 ( Pt 11):1785-95. PMID: 10318770.
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    42. Hunger-Glaser I, Brun R, Linder M, Seebeck T. Inhibition of succinyl CoA synthetase histidine-phosphorylation in Trypanosoma brucei by an inhibitor of bacterial two-component systems. Mol Biochem Parasitol. 1999 May 15; 100(1):53-9. PMID: 10376993.
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    43. Hunger-Glaser I, Linder M, Seebeck T. Histidine-phosphorylation of succinyl CoA synthetase from Trypanosoma brucei. Mol Biochem Parasitol. 1999 May 15; 100(1):43-52. PMID: 10376992.
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    44. Hunger-Glaser I, Seebeck T. Deletion of the genes for the paraflagellar rod protein PFR-A in Trypanosoma brucei is probably lethal. Mol Biochem Parasitol. 1997 Dec 01; 90(1):347-51. PMID: 9497059.
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    45. Detmer E, Hemphill A, Müller N, Seebeck T. The Trypanosoma brucei autoantigen I/6 is an internally repetitive cytoskeletal protein. Eur J Cell Biol. 1997 Apr; 72(4):378-84. PMID: 9127738.
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    46. Wilson W, Seebeck T. Identification of a profilin homologue in Trypanosoma brucei by complementation screening. Gene. 1997 Mar 18; 187(2):201-9. PMID: 9099881.
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    47. Müller N, Mansfield JM, Seebeck T. Trypanosome variant surface glycoproteins are recognized by self-reactive antibodies in uninfected hosts. Infect Immun. 1996 Nov; 64(11):4593-7. PMID: 8890212; PMCID: PMC174418.
    48. Imboden M, Müller N, Hemphill A, Mattioli R, Seebeck T. Repetitive proteins from the flagellar cytoskeleton of African trypanosomes are diagnostically useful antigens. Parasitology. 1995 Apr; 110 ( Pt 3):249-58. PMID: 7724233.
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    49. Deflorin J, Rudolf M, Seebeck T. The major components of the paraflagellar rod of Trypanosoma brucei are two similar, but distinct proteins which are encoded by two different gene loci. J Biol Chem. 1994 Nov 18; 269(46):28745-51. PMID: 7961827.
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    50. Affolter M, Hemphill A, Roditi I, Müller N, Seebeck T. The repetitive microtubule-associated proteins MARP-1 and MARP-2 of Trypanosoma brucei. J Struct Biol. 1994 May-Jun; 112(3):241-51. PMID: 7986649.
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    51. Müller N, Imboden M, Detmer E, Mansfield JM, Seebeck T. Cytoskeleton-associated antigens from African trypanosomes are recognized by self-reactive antibodies of uninfected mice. Parasitology. 1993 Nov; 107 ( Pt 4):411-7. PMID: 7506406.
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    52. Rindisbacher L, Hemphill A, Seebeck T. A repetitive protein from Trypanosoma brucei which caps the microtubules at the posterior end of the cytoskeleton. Mol Biochem Parasitol. 1993 Mar; 58(1):83-96. PMID: 8459837.
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    53. Hemphill A, Affolter M, Seebeck T. A novel microtubule-binding motif identified in a high molecular weight microtubule-associated protein from Trypanosoma brucei. J Cell Biol. 1992 Apr; 117(1):95-103. PMID: 1348252; PMCID: PMC2289396.
    54. Müller N, Hemphill A, Imboden M, Duvallet G, Dwinger RH, Seebeck T. Identification and characterization of two repetitive non-variable antigens from African trypanosomes which are recognized early during infection. Parasitology. 1992 Feb; 104 Pt 1:111-20. PMID: 1614728.
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    55. Hemphill A, Seebeck T, Lawson D. The Trypanosoma brucei cytoskeleton: ultrastructure and localization of microtubule-associated and spectrin-like proteins using quick-freeze, deep-etch, immunogold electron microscopy. J Struct Biol. 1991 Dec; 107(3):211-20. PMID: 1725491.
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    56. Hemphill A, Lawson D, Seebeck T. The cytoskeletal architecture of Trypanosoma brucei. J Parasitol. 1991 Aug; 77(4):603-12. PMID: 1865269.
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    57. Seebeck T. Molecular biology and parasites. Experientia. 1991 Feb 15; 47(2):163-6. PMID: 2001718.
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    58. Schlaeppi K, Deflorin J, Seebeck T. The major component of the paraflagellar rod of Trypanosoma brucei is a helical protein that is encoded by two identical, tandemly linked genes. J Cell Biol. 1989 Oct; 109(4 Pt 1):1695-709. PMID: 2793936; PMCID: PMC2115804.
    59. Müller N, Gottstein B, Vogel M, Flury K, Seebeck T. Application of a recombinant Echinococcus multilocularis antigen in an enzyme-linked immunosorbent assay for immunodiagnosis of human alveolar echinococcosis. Mol Biochem Parasitol. 1989 Sep; 36(2):151-9. PMID: 2671725.
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    60. Schlaeppi K, Seebeck T. A silent open reading frame of Trypanosoma brucei coding for a protein which shares epitopes with the major structural protein of the paraflagellar rod. Nucleic Acids Res. 1989 Jul 11; 17(13):5399. PMID: 2474796; PMCID: PMC318138.
    61. Kueng V, Schlaeppi K, Schneider A, Seebeck T. A glycosomal protein (p60) which is predominantly expressed in procyclic Trypanosoma brucei. Characterization and DNA sequence. J Biol Chem. 1989 Mar 25; 264(9):5203-9. PMID: 2925689.
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    62. Müller N, Vogel M, Gottstein B, Scholle A, Seebeck T. Plasmid vector for overproduction and export of recombinant protein in Escherichia coli: efficient one-step purification of a recombinant antigen from Echinococcus multilocularis (Cestoda). Gene. 1989 Feb 20; 75(2):329-34. PMID: 2523840.
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    63. Vogel M, Gottstein B, Müller N, Seebeck T. Production of a recombinant antigen of Echinococcus multilocularis with high immunodiagnostic sensitivity and specificity. Mol Biochem Parasitol. 1988 Nov; 31(2):117-25. PMID: 3185617.
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    64. Schneider A, Hemphill A, Wyler T, Seebeck T. Large microtubule-associated protein of T. brucei has tandemly repeated, near-identical sequences. Science. 1988 Jul 22; 241(4864):459-62. PMID: 3393912.
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    65. Schneider A, Lutz HU, Marugg R, Gehr P, Seebeck T. Spectrin-like proteins in the paraflagellar rod structure of Trypanosoma brucei. J Cell Sci. 1988 Jun; 90 ( Pt 2):307-15. PMID: 3073166.
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    66. Schneider A, Eichenberger W, Seebeck T. A microtubule-binding protein of Trypanosoma brucei which contains covalently bound fatty acid. J Biol Chem. 1988 May 15; 263(14):6472-5. PMID: 3360790.
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    67. Ben Amar MF, Pays A, Tebabi P, Dero B, Seebeck T, Steinert M, Pays E. Structure and transcription of the actin gene of Trypanosoma brucei. Mol Cell Biol. 1988 May; 8(5):2166-76. PMID: 3386635; PMCID: PMC363398.
    68. Seebeck T, Küng V, Wyler T, Müller M. A 60-kDa cytoskeletal protein from Trypanosoma brucei brucei can interact with membranes and with microtubules. Proc Natl Acad Sci U S A. 1988 Feb; 85(4):1101-4. PMID: 3422481; PMCID: PMC279713.
    69. Imboden MA, Laird PW, Affolter M, Seebeck T. Transcription of the intergenic regions of the tubulin gene cluster of Trypanosoma brucei: evidence for a polycistronic transcription unit in a eukaryote. Nucleic Acids Res. 1987 Sep 25; 15(18):7357-68. PMID: 3658696; PMCID: PMC306253.
    70. Schneider A, Sherwin T, Sasse R, Russell DG, Gull K, Seebeck T. Subpellicular and flagellar microtubules of Trypanosoma brucei brucei contain the same alpha-tubulin isoforms. J Cell Biol. 1987 Mar; 104(3):431-8. PMID: 3818788; PMCID: PMC2114526.
    71. Sherwin T, Schneider A, Sasse R, Seebeck T, Gull K. Distinct localization and cell cycle dependence of COOH terminally tyrosinolated alpha-tubulin in the microtubules of Trypanosoma brucei brucei. J Cell Biol. 1987 Mar; 104(3):439-46. PMID: 3546334; PMCID: PMC2114556.
    72. Stieger J, Seebeck T. Monoclonal antibodies against a 60 kDa phenothiazine-binding protein from Trypanosoma brucei can discriminate between different trypanosome species. Mol Biochem Parasitol. 1986 Oct; 21(1):37-45. PMID: 2430179.
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    73. Imboden M, Blum B, DeLange T, Braun R, Seebeck T. Tubulin mRNAs of Trypanosoma brucei. J Mol Biol. 1986 Apr 05; 188(3):393-402. PMID: 3735427.
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    74. Gull K, Hussey PJ, Sasse R, Schneider A, Seebeck T, Sherwin T. Tubulin isotypes: generation of diversity in cells and microtubular organelles. J Cell Sci Suppl. 1986; 5:243-55. PMID: 3477554.
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    75. Seebeck T, Kurath U. Two simple media for biochemical experimentation with cultured procyclic Trypanosoma brucei. Acta Trop. 1985 Jun; 42(2):127-36. PMID: 2862774.
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    76. Stieger J, Wyler T, Seebeck T. Partial purification and characterization of microtubular protein from Trypanosoma brucei. J Biol Chem. 1984 Apr 10; 259(7):4596-602. PMID: 6707021.
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    77. Seebeck T, Gehr P. Trypanocidal action of neuroleptic phenothiazines in Trypanosoma brucei. Mol Biochem Parasitol. 1983 Nov; 9(3):197-208. PMID: 6144043.
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    78. Seebeck T, Whittaker PA, Imboden MA, Hardman N, Braun R. Tubulin genes of Trypanosoma brucei: a tightly clustered family of alternating genes. Proc Natl Acad Sci U S A. 1983 Aug; 80(15):4634-8. PMID: 6308633; PMCID: PMC384098.
    79. Stalder J, Seebeck T, Braun R. Degradation of the ribosomal genes by DNAse I in Physarum polycephalum. Eur J Biochem. 1978 Oct; 90(2):391-5. PMID: 710437.
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