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Dr Edward Mberu Kamau

TitleTechnical Officer
InstitutionWHO/TDR
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    Collapse Overview 
    Collapse overview
    Dr. Kamau is a Technical Officer at WHO/TDR providing support for research project management. Prior to joining TDR, he worked as a Research Associate and Laboratory Specialist at Family Health International (FHI360), Africa Regional Office, Nairobi, Kenya. Before joining FHI360, he worked as a Diagnosis Officer in the Malaria Unit, WHO/AFRO, Harare, Zimbabwe. Dr Kamau held a two-year WHO/TDR Career Development Fellowship on Project Management of Tropical Diseases Research in Africa. In addition, Dr. Kamau held a one-year postdoctoral fellowship with the Department of Pathobiology at the University of Washington, Seattle, USA.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ogundahunsi OA, Vahedi M, Kamau EM, Aslanyan G, Terry RF, Zicker F, Launois P. Strengthening research capacity--TDR's evolving experience in low- and middle-income countries. PLoS Negl Trop Dis. 2015 Jan; 9(1):e3380. PMID: 25569232.
      View in: PubMed
    2. Lema VM, Mbondo M, Kamau EM. Informed consent for clinical trials: a review. East Afr Med J. 2009 Mar; 86(3):133-42. PMID: 19702101.
      View in: PubMed
    3. Nduati EW, Kamau EM. Multiple synergistic interactions between atovaquone and antifolates against Plasmodium falciparum in vitro: a rational basis for combination therapy. Acta Trop. 2006 Mar; 97(3):357-63. PMID: 16457769.
      View in: PubMed
    4. Kamau EM. Roll Back Malaria and the new partnership for Africa's development: is there potential for synergistic collaboration in partnerships? Afr J Health Sci. 2006 Jan-Jun; 13(1-2):22-7. PMID: 17348739.
      View in: PubMed
    5. Kamau EM. Field-derived research materials in the African region: challenges and opportunities for the malaria researcher. Acta Trop. 2005 Sep; 95(3):167-71. PMID: 16193552.
      View in: PubMed
    6. Nduati E, Hunt S, Kamau EM, Nzila A. 2,4-diaminopteridine-based compounds as precursors for de novo synthesis of antifolates: a novel class of antimalarials. Antimicrob Agents Chemother. 2005 Sep; 49(9):3652-7. PMID: 16127035.
      View in: PubMed
    7. Nyangulu JM, Hargreaves SL, Sharples SL, Mackay SP, Waigh RD, Duval O, Mberu EK, Watkins WM. Antimalarial benzo[c]phenanthridines. Bioorg Med Chem Lett. 2005 Apr 15; 15(8):2007-10. PMID: 15808457.
      View in: PubMed
    8. Kamau EM. Intergrating operational research in scaling up malaria control interventions in the African region: a practical perspective. East Afr Med J. 2005 Mar; 82(3):160-2. PMID: 16122080.
      View in: PubMed
    9. Ommeh S, Nduati E, Mberu E, Kokwaro G, Marsh K, Rosowsky A, Nzila A. In vitro activities of 2,4-diaminoquinazoline and 2,4-diaminopteridine derivatives against Plasmodium falciparum. Antimicrob Agents Chemother. 2004 Oct; 48(10):3711-4. PMID: 15388424.
      View in: PubMed
    10. Patel OG, Mberu EK, Nzila AM, Macreadie IG. Sulfa drugs strike more than once. Trends Parasitol. 2004 Jan; 20(1):1-3. PMID: 14700578.
      View in: PubMed
    11. Nzila A, Mberu E, Bray P, Kokwaro G, Winstanley P, Marsh K, Ward S. Chemosensitization of Plasmodium falciparum by probenecid in vitro. Antimicrob Agents Chemother. 2003 Jul; 47(7):2108-12. PMID: 12821454.
      View in: PubMed
    12. Lochhead J, Movaffaghy A, Falsini B, Winstanley PA, Mberu EK, Riva CE, Molyneux ME, Taylor TE, Harding SP. The effect of quinine on the electroretinograms of children with pediatric cerebral malaria. J Infect Dis. 2003 Apr 15; 187(8):1342-5. PMID: 12696018.
      View in: PubMed
    13. Nzila AM, Mberu EK, Nduati E, Ross A, Watkins WM, Sibley CH. Genetic diversity of Plasmodium falciparum parasites from Kenya is not affected by antifolate drug selection. Int J Parasitol. 2002 Nov; 32(12):1469-76. PMID: 12392912.
      View in: PubMed
    14. Mberu EK, Nzila AM, Nduati E, Ross A, Monks SM, Kokwaro GO, Watkins WM, Hopkins Sibley C. Plasmodium falciparum: in vitro activity of sulfadoxine and dapsone in field isolates from Kenya: point mutations in dihydropteroate synthase may not be the only determinants in sulfa resistance. Exp Parasitol. 2002 Jun-Jul; 101(2-3):90-6. PMID: 12427462.
      View in: PubMed
    15. Sibley CH, Hyde JE, Sims PF, Plowe CV, Kublin JG, Mberu EK, Cowman AF, Winstanley PA, Watkins WM, Nzila AM. Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next? Trends Parasitol. 2001 Dec; 17(12):582-8. PMID: 11756042.
      View in: PubMed
    16. Mutabingwa T, Nzila A, Mberu E, Nduati E, Winstanley P, Hills E, Watkins W. Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania. Lancet. 2001 Oct 13; 358(9289):1218-23. PMID: 11675058.
      View in: PubMed
    17. Oketch-Rabah HA, Mwangi JW, Lisgarten J, Mberu EK. A new antiplasmodial coumarin from Toddalia asiatica roots. Fitoterapia. 2000 Dec; 71(6):636-40. PMID: 11077169.
      View in: PubMed
    18. Nzila AM, Nduati E, Mberu EK, Hopkins Sibley C, Monks SA, Winstanley PA, Watkins WM. Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum. J Infect Dis. 2000 Jun; 181(6):2023-8. PMID: 10837185.
      View in: PubMed
    19. Nzila AM, Mberu EK, Sulo J, Dayo H, Winstanley PA, Sibley CH, Watkins WM. Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites. Antimicrob Agents Chemother. 2000 Apr; 44(4):991-6. PMID: 10722502.
      View in: PubMed
    20. Mberu EK, Mosobo MK, Nzila AM, Kokwaro GO, Sibley CH, Watkins WM. The changing in vitro susceptibility pattern to pyrimethamine/sulfadoxine in Plasmodium falciparum field isolates from Kilifi, Kenya. Am J Trop Med Hyg. 2000 Mar; 62(3):396-401. PMID: 11037785.
      View in: PubMed
    21. Kinyanjui SM, Mberu EK, Winstanley PA, Jacobus DP, Watkins WM. The antimalarial triazine WR99210 and the prodrug PS-15: folate reversal of in vitro activity against Plasmodium falciparum and a non-antifolate mode of action of the prodrug. Am J Trop Med Hyg. 1999 Jun; 60(6):943-7. PMID: 10403325.
      View in: PubMed
    22. Watkins WM, Mberu EK, Winstanley PA, Plowe CV. More on 'the efficacy of antifolate antimalarial combinations in Africa'. Parasitol Today. 1999 Apr; 15(4):131-2. PMID: 10322331.
      View in: PubMed
    23. Nzila-Mounda A, Mberu EK, Sibley CH, Plowe CV, Winstanley PA, Watkins WM. Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain. Antimicrob Agents Chemother. 1998 Jan; 42(1):164-9. PMID: 9449279.
      View in: PubMed
    24. Watkins WM, Mberu EK, Winstanley PA, Plowe CV. The efficacy of antifolate antimalarial combinations in Africa: a predictive model based on pharmacodynamic and pharmacokinetic analyses. Parasitol Today. 1997 Dec; 13(12):459-64. PMID: 15275132.
      View in: PubMed
    25. Murphy SA, Mberu E, Muhia D, English M, Crawley J, Waruiru C, Lowe B, Newton CR, Winstanley P, Marsh K, Watkins WM. The disposition of intramuscular artemether in children with cerebral malaria; a preliminary study. Trans R Soc Trop Med Hyg. 1997 May-Jun; 91(3):331-4. PMID: 9231211.
      View in: PubMed
    26. Connelly MP, Fabiano E, Patel IH, Kinyanjui SM, Mberu EK, Watkins WM. Antimalarial activity in crude extracts of Malawian medicinal plants. Ann Trop Med Parasitol. 1996 Dec; 90(6):597-602. PMID: 9039271.
      View in: PubMed
    27. Mberu EK, Muhia DK, Minyiri GO, Njonge EW, Watkins WM. Measurement of physiological concentrations of dapsone and its monoacetyl metabolite: a miniaturised assay for liquid or filter paper-absorbed samples. J Chromatogr B Biomed Appl. 1996 Mar 03; 677(2):385-7. PMID: 8704946.
      View in: PubMed
    28. Watkins WM, Mungai M, Muhia DK, Mberu EK, Gathua S, Winstanley PA, Gilks CF, Nunn P. Cutaneous hypersensitivity reactions to thiacetazone, HIV infection and thiacetazone concentrations in plasma. Br J Clin Pharmacol. 1996 Feb; 41(2):160-2. PMID: 8838444.
      View in: PubMed
    29. Gakunju DM, Mberu EK, Dossaji SF, Gray AI, Waigh RD, Waterman PG, Watkins WM. Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy. Antimicrob Agents Chemother. 1995 Dec; 39(12):2606-9. PMID: 8592987.
      View in: PubMed
    30. Mberu EK, Wansor T, Sato H, Nishikawa Y, Watkins WM. Japanese poor metabolizers of proguanil do not have an increased risk of malaria chemoprophylaxis breakthrough. Trans R Soc Trop Med Hyg. 1995 Nov-Dec; 89(6):658-9. PMID: 8594689.
      View in: PubMed
    31. Winstanley PA, Mberu EK, Szwandt IS, Breckenridge AM, Watkins WM. In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrob Agents Chemother. 1995 Apr; 39(4):948-52. PMID: 7786001.
      View in: PubMed
    32. Watkins WM, Winstanley PA, Mberu EK, Kokwaro G, Murphy SA, Newton CJ, Mwangi I, Forster D, Marsh K. Halofantrine pharmacokinetics in Kenyan children with non-severe and severe malaria. Br J Clin Pharmacol. 1995 Mar; 39(3):283-7. PMID: 7619670.
      View in: PubMed
    33. Muhia DK, Mberu EK, Watkins WM. Differential extraction of artemether and its metabolite dihydroartemisinin from plasma and determination by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1994 Oct 03; 660(1):196-9. PMID: 7858715.
      View in: PubMed
    34. Winstanley PA, Mberu EK, Watkins WM, Murphy SA, Lowe B, Marsh K. Towards optimal regimens of parenteral quinine for young African children with cerebral malaria: unbound quinine concentrations following a simple loading dose regimen. Trans R Soc Trop Med Hyg. 1994 Sep-Oct; 88(5):577-80. PMID: 7992345.
      View in: PubMed
    35. Muhia DK, Thomas CG, Ward SA, Edwards G, Mberu EK, Watkins WM. Ferriprotoporphyrin catalysed decomposition of artemether: analytical and pharmacological implications. Biochem Pharmacol. 1994 Aug 30; 48(5):889-95. PMID: 8093101.
      View in: PubMed
    36. Murphy SA, Mberu E. A study of the comparative bioavailability of pyrimethamine-sulfadoxine obtained from two oral preparations. East Afr Med J. 1994 May; 71(5):328-9. PMID: 7925067.
      View in: PubMed
    37. Newton CR, Winstanley PA, Watkins WM, Mwangi IN, Waruiru CM, Mberu EK, Warn PA, Nevill CG, Marsh K. A single dose of intramuscular sulfadoxine-pyrimethamine as an adjunct to quinine in the treatment of severe malaria: pharmacokinetics and efficacy. Trans R Soc Trop Med Hyg. 1993 Mar-Apr; 87(2):207-10. PMID: 8337731.
      View in: PubMed
    38. Winstanley P, Newton C, Watkins W, Mberu E, Ward S, Warn P, Mwangi I, Waruiru C, Pasvol G, Warrell D, et al. Towards optimal regimens of parenteral quinine for young African children with cerebral malaria: the importance of unbound quinine concentration. Trans R Soc Trop Med Hyg. 1993 Mar-Apr; 87(2):201-6. PMID: 8337730.
      View in: PubMed
    39. Mberu EK, Muhia DK, Watkins WM. Measurement of halofantrine and its major metabolite desbutylhalofantrine in plasma and blood by high-performance liquid chromatography: a new methodology. J Chromatogr. 1992 Oct 02; 581(1):156-60. PMID: 1430001.
      View in: PubMed
    40. Winstanley PA, Watkins WM, Newton CR, Nevill C, Mberu E, Warn PA, Waruiru CM, Mwangi IN, Warrell DA, Marsh K. The disposition of oral and intramuscular pyrimethamine/sulphadoxine in Kenyan children with high parasitaemia but clinically non-severe falciparum malaria. Br J Clin Pharmacol. 1992 Feb; 33(2):143-8. PMID: 1550695.
      View in: PubMed
    41. Winstanley PA, Newton CR, Pasvol G, Kirkham FJ, Mberu E, Peshu N, Ward SA, Were JB, Warrell DA, Marsh K. Prophylactic phenobarbitone in young children with severe falciparum malaria: pharmacokinetics and clinical effects. Br J Clin Pharmacol. 1992 Feb; 33(2):149-54. PMID: 1550696.
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    42. Mberu EK, Ward SA, Winstanley PA, Watkins WM. Measurement of quinine in filter paper-absorbed blood by high-performance liquid chromatography. J Chromatogr. 1991 Sep 18; 570(1):180-4. PMID: 1797824.
      View in: PubMed
    43. Helsby NA, Watkins WM, Mberu E, Ward SA. Inter-individual variation in the metabolic activation of the antimalarial biguanides. Parasitol Today. 1991 May; 7(5):120-3. PMID: 15463463.
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    44. Watkins WM, Mberu EK, Nevill CG, Ward SA, Breckenridge AM, Koech DK. Variability in the metabolism of proguanil to the active metabolite cycloguanil in healthy Kenyan adults. Trans R Soc Trop Med Hyg. 1990 Jul-Aug; 84(4):492-5. PMID: 2091335.
      View in: PubMed
    45. Ward SA, Watkins WM, Mberu E, Saunders JE, Koech DK, Gilles HM, Howells RE, Breckenridge AM. Inter-subject variability in the metabolism of proguanil to the active metabolite cycloguanil in man. Br J Clin Pharmacol. 1989 Jun; 27(6):781-7. PMID: 2757894.
      View in: PubMed
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